{"text_format":"5","workbook":"xls","n_sheets":1,"sheets":["Matching strains"],"props":{"last_modified_by":"tomcat"},"not_rendered":{"external_links":1},"cells_cut":1,"read":"whole","wrapped":"gz","date_system":"1900","formulas":"cached_only"}

{"sheet":"Matching strains","index":0,"n_rows":4986,"n_cols":59,"rows_kept":2250,"cut":true,"merged":[[0,17,0,23],[0,24,0,25],[0,26,0,27]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1},"flags":["formulas_cached_only"]}
[{"$nulls":17},"Exon",{"$nulls":6},"Intron",null,"Custom"]
["ID","Nickname","Name","Designation","Mode of inheritance","Gene name","Gene symbol","Protein expression of altered gene","Gene synonyms","MGI Gene accession ID","Allele Name","Allele symbol","MGI Allele accession ID","Chromosome","Ensemble Gene ID","Transcript ID","Transcript name","bp coding sequence position","bp cdna sequence position","bp change","Exon ID","Exon number","Amino acid position","Amino acid change","Genomic position","Intron number","Mutation type","Strand type","Coding Sequence","Novelty","Transgene name","Transgene promoter","Transgene expression level","Congenic Gene name","Congenic Gene symbol","Congenic Protein expression of altered gene","Congenic Gene synonyms","Congenic MGI Gene accession ID","Congenic Allele Name","Congenic Allele symbol","Congenic MGI Allele accession ID","Congenic Gene Chromosome","Homozygous phenotype","Heterozygous phenotype","Current genetic background","Female homozygous viable","Female homozygous fertile","Female heterozygotes/hemizygotes fertile","Male homozygous viable","Male homozygous fertile","Male heterozygotes/hemizygotes fertile","Evidence of compromised male fertility","Breeding performance","# generations backcrossed to background strain","# sib-mated generations","Mating scheme","Requires homozygous matings","Date created (dd/mm/yyyy)","Stock stored as"]
[1776,"Bim / IL7r Knockout","C57BL/6-Bcl2l11<tm1.1Ast> IL7r<tm1Imx>/Wehi",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Reduced","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"No",{"$nulls":12},"Bim/IL-7Ralpha double deficient mice have significantly increased thymocyte numbers, restored near normal numbers of mature T cells in the blood and spleen, and enhanced cytotoxic T cell responses to virus infection in IL-7Ralpha-/- mice compared to IL7R KO alone. These results indicate that Bim cooperates with other proapoptotic proteins in the death of IL-7-deprived T cell progenitors in vivo, but is the major inducer of this pathway to apoptosis in mature T cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1776,"Bim / IL7r Knockout","C57BL/6-Bcl2l11<tm1.1Ast> IL7r<tm1Imx>/Wehi",null,"Recessive","interleukin 7 receptor","Il7r","Nil","CD127, IL-7 receptor alpha chain, IL-7Ralpha","MGI:96562","interleukin 7 receptor; targeted mutation 1, Immunex","Il7r<tm1Imx>","MGI:1857198","Unknown",{"$nulls":15},"No"]
[5121,"GDNF+/-","C57BL/6-Gdnf<tm1Lmgd>",null,"Recessive","glial cell line derived neurotrophic factor","Gdnf","Unknown","glial cell line-derived neurotrophic factor","MGI:107430","glial cell line derived neurotrophic factor; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal","Gdnf<tm1Lmgd>","MGI:2136846","15",{"$nulls":15},"No",{"$nulls":12},"Neonatal lethality: die 12-24 hours after birthAbnormal kidney development: * severe renal dysgenesis or renal agenesis * metanephric development is halted between E11 and E14.5Abnormal ureteric bud morphology: ureteric bud is absent in most mice.Absent kidney.Abnormal ureter development: delayed or total absence of ureteric branching in cultured urogenital blocks.Abnormal enteric cholinergic neuron morphology: devoid of enteric parasympathetic cholinergic ganglion cells.Absent enteric neurons: neurons of the myenteric plexus are absent from the intestine.Hypoperistalsis: presence of milk in the oesophagus and reduced progression of food into the gastrointestinal tract.","On 129 background:Abnormal kidney morphology: 35% possess a wide range of renal defects between 3 to 5 months of age.Abnormal kidney development: 12% have severe bilateral kidney dysgenesis.Abnormal ureteric bud morphology: ureteric bud defects.Abnormal ureteric bud branching morphogenesis: reduced ureteric branching in cultured urogenital blocks.Small kidney: 23% have unilateral small kidneys with abnormal shape and/or cortical cysts or rough surface.Single kidney: unilateral kidney agenesis.On 129 x C57BL/6 backgroundPostnatal lethality: * Background Sensitivity: 17.1% preweaning lethality on the C57BL/6 background and 8.4% preweaning lethality on the CD-1 background which increased to 16.7% after interbreeding of offspring on the CD-1 background. * low, but highly significant, preweaning lethalitySingle kidney: 10% exhibit unilateral kidney agenesisAbnormal enteric ganglia morphology * hypoganglionisis, as indicated by reduced numbers and mesh density of ganglionic cells in both the myenteric and the submucosal plexus formations of the gastrointestinal tract. * 64% reduction of ganglionic cells in the ileocecum and colon and 50% reduction in the stomach and small intestine. * exhibit aganglionic regions interspersed along the hypoganglionic regions of the intestine.Megacolon: 84% have varying degrees of colon dilationAbnormal stomach morphology: 38.5% exhibit stomach distention.Chronic constipation: 74% exhibit fecal retention, a sign of chronic constipation.Hypoperistalsis: delayed gastric emptying of milk in newborns, indicating impaired intestinal motility.","C57BL/6","No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2010-05-12","Cryopreserved sperm"]
[4451,null,"129/SvEv.OLA x C57BL/6",null,"Dominant",{"$nulls":39},"129/Sv x 129/OLA x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-20","Cryopreserved sperm"]
[4958,"EGFP<tg1>","C57BL/6-Gt(ROSA)26Sor<tm1(GAP43)Gld> Alpl<tm1(cre)Nagy",null,"Dominant","alkaline phosphatase, liver/bone/kidney","Alpl","Unknown","Akp-2, Akp2, TNAP, TNSALP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Martyn Goulding",{"$nulls":12},"Expression of GFP in all cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-18"]
[705,null,"NOD.B6-Tg(ML5sHEL)5Ccg/Dvs",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 5, Christopher C Goodnow","mouse metallothionein I","High",{"$nulls":9},"Mice homozygous for the TgN(ML5sHEL)5Ccg transgene express a soluble form of hen egg lysozyme.",null,"NOD/lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-02"]
[5277,"MIP-GFP","NOD.Cg-Tg(Ins1-EGFP)1Hara",null,"Dominant",{"$nulls":25},"transgene insertion 1, Manami Hara","mouse insulin 1 gene","High",{"$nulls":10},"The MIP-GFP mice develop normally and are indistinguishable from control animals with respect to glucose tolerance and pancreatic insulin content. Histological studies showed that the MIP-GFP mice had normal islet architecture with coexpression of insulin and GFP in the beta-cells of all islets. Observed GFP expression in islets from embryonic day E13.5 through adulthood.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[846,"Traf2 KO","C57BL/6-Traf2<tm1.1Rbr>",null,"Recessive","Tnf receptor-associated factor 2","Traf2","Nil",null,"MGI:101835","targeted mutation 1.1, Robert Brink","Traf2<tm1.1Rbr>","MGI:3511496","2",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[6417,"GRB7Δ","B6.CBA-Grb7<tm1>/Ausb",null,"Recessive","growth factor receptor bound protein 7","Grb7","Unknown",null,"MGI:102683",{"$nulls":3},"11",{"$nulls":28},"Cell metastasis",null,"C57BL/6 x CBA","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[6779,"SIGMA-J20","B6.Cg-Tg(PDGFB-APPSwInd)20Lms/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 20, Lennart Mucke ","human platelet derived growth factor, B polypeptide (PDGFB) promoter","highest level of expression occurring in the neocortex and hippocampus",{"$nulls":9},"Unknown","At five to seven months of age diffuse amyloid beta peptides deposition in the dendate gyrus and neocortex forms","C57BL6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","12",null,"hemizygous males are bred to wildtype siblings or to C57BL/6J inbred females. Pups born of carrier females have shown an increased mortality rate in our colonies.","No","2012-01-12"]
[226,"129.ZEG","129-Tg(CAG-Bgeo/GFP)21Lbe",null,"Dominant",{"$nulls":25},"transgene insertion 21, Corrinne Lobe","CMV enhancer/chicken beta actin promoter",{"$nulls":10},"Mice that are homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioural abnormalities.  Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages.Expresses enhanced GFP upon Cre-mediated excision.Used as a reporter of Cre-recombinase activity, for either stage-or tissue-specificity, following the excision of the floxed target and activation of the EGFP transgene.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25"]
[2421,"B10.H2g7","B10.NOD-H2<g7>/AnuApb","B10.NOD-H2<g7>/AnuApb","Recessive","histocompatibility-2, MHC","H2","Normal","H-2, MHC-II","MGI:95894","g7 variant","H2<g7>","MGI:3579321","17",{"$nulls":15},"Yes",{"$nulls":12},"The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component. The g7 variant is found in NOD strain",null,"C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-10","Cryopreserved sperm"]
[6808,"Dudley","SJL/Mrit-Gck<MRI32652>/MritApb",null,"Dominant","Glucokinase","Gck","Unknown","Gk, hexokinase 4, HK4, MODY2","MGI:1270854","Glucokinase;MRI32562","Gck<MRI32562>",null,"11",{"$nulls":28},"Growth retardationDramatic hyperglycemia","HyperglycemiaHyperinsulinemiaGlucose intolerant","SJL","Yes","No","Yes","Yes","No","Yes","No","Good",{"$nulls":3},"No","2012-02-01","Cryopreserved sperm"]
[7634,null,"SJL/ASAM<MRI115171>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[3536,null,"B6.SJL-Tg(Nes-cre)1Kln",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 1, Rudiger Klein ","rat nestin (Nes)",{"$nulls":10},"Normal.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29"]
[6655,"HICAM","B6.129S4-Icam1<tm1Jcgr>/J/Ausb",null,"Recessive","intercellular adhesion molecule 1 ","Icam1","Nil","CD54, Icam-1, Ly-47, MALA-2, MGC:6195","MGI:96392","intercellular adhesion molecule 1; targeted mutation 1, Jose Carlos Gutierrez Ramos","Icam1<tm1Jcgr>","MGI:1857292","9",{"$nulls":28},"Abnormal cardiac muscle contractility:*Lipopolysaccharide (LPS) treatment does not result in a decrease in left ventricular contractility as is seen in wild-type, indicating a lack of LPS-induced myocardial dysfunction.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[4772,"4AT31","ENU4AT:031",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[5939,"Nf1bCond/NestinCre/Rosa26",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5938,"Nf1BCond/NesCreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6899,"B6.BlGpA ; B6.TgN(HUFUT1-HUGTA-MUSMICAM2)","C57BL/6-Tg(Icam2-FUT1, GTA)/StV",null,"Dominant",{"$nulls":25},"human H-transferase and human A-transferase","ICAM2",{"$nulls":10},"Expression of human blood group A on vascular endothelium and on a subset of polymorphonuclear cells","Expression of human blood group A on vascular endothelium and on a subset of polymorphonuclear cells","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent","20",null,null,"No","2012-05-24","Cryopreserved sperm"]
[3924,"CC","BALB/c-Tg(Col1a2-cre/ESR1)7Cpd/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 7, Christopher P Denton","Col1a2 enhancer","fibroblast-specific expression, restricted to collagen",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Backcross to balb/c","No","2008-10-14","Cryopreserved sperm"]
[211,"NRG1 KO","C57BL/6-Nrg1<tm1Cbm> ",null,"Recessive","neuregulin 1","Nrg1","Unknown","GGF, GGFII, heregulin, HGL, Hgl, HRG, HRGalpha, NDF, SMDF, ARIA","MGI:96083","targeted mutation 1, Carmen Birchmeier","Nrg1<tm1Cbm>","MGI:1928489","8",{"$nulls":15},"No",{"$nulls":12},"Mice die at E10.5 due to severe cardiac defects (lack of cardiac trabeculae). In addition, Schwann cell precursors and cranial ganglia fail to develop normally in NRG1-/- mice.","None reported","C57BL/6J","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[4774,"5AT129","ENU5AT:129",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[6826,"APP KO","B6.129-App<tm1Dbo>/Apb",null,"Recessive","amyloid beta (A4) precursor protein","App","Nil","Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II","MGI:88059","amyloid beta (A4) precursor protein; targeted mutation 1, David R Borchelt","App<tm1Dbo>","MGI:2136847","16",{"$nulls":28},"Abnormal active avoidance behavior: age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age.Abnormal spatial learning: impairment in watermaze test of spatial learning, both at 4 and 10 months of age.Decreased grip strength: significantly reduced grip strength.Abnormal locomotor activation: decreased locomotor activityHypoactivity.Gliosis: reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage.Astrocytosis: reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age.Abnormal neuron morphology: the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus.Abnormal long term potentiation: impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum.Decreased body weight: body weight was 15-20% less at all ages compared with that of controls.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-02-27","Cryopreserved sperm"]
[4579,null,"SJL.129S7-Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal immune system",null,"SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm"]
[5279,"MacBlue","NOD.B6-Tg(Csf1r-Gal4VP16/UAS-ECFP)",null,"Dominant",{"$nulls":25},"Gal4VP16 transcriptional activator , enhanced cyan fluorescent protein (ECFP)","Csf1r and Gal4",{"$nulls":10},"Expression of ECFP in macrophages.ECFP expression in transgenic embryos was first detectable at 8 dpc in the blood islands of the proximal yolk sac.ECFP<+> macrophages were concentrated in areas of increased apoptotic cell death, such as necrotic zones of the developing limb, consistent with their proposed scavenger function.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[7635,null,"SJL/ASAM<MRI131621>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[8556,null,"hRhD L3 het ",null,"Recessive","human RhD",{"$nulls":7},"Unknown",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"human RhD expressed on murine RBC","human RhD expressed on murine RBC",null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2018-09-13","Cryopreserved sperm"]
[6850,"Grhl1KO","C57BL/6-Grhl1<tm1Jane>/MarpApb",null,"Recessive","grainyhead-like 1 (Drosophila)","Grhl1","Nil","LBP-32, p61 MGR, p70 MGR, Tcfcp2l2","MGI:2182540","grainyhead-like 1 (Drosophila); targeted mutation 1, Stephen M Jane","Grhl1<tm1Jane>","MGI:3778923","2",{"$nulls":28},"Homozygous mice are small and have a variable hair phenotype leading to hair loss.Postnatal growth retardation: similar in size at birth and at 2 months of age but significantly smaller than littermate controls at weaning.Cardiovascular system phenotype: unlike human patients with striate palmoplantar keratoderma disorder, no evidence of cardiomyopathy is detected.Alopecia: * over 30% of mice lack hair at weaning with the remainder having sparse coats * extensive regional hair loss is seen when mice are housed with other mice with regrowth when mice are housed alone * despite the thinner coat, in a tape-stripping test more hairs are removed compared to wild-type controls.Delayed hair appearance: delay in coat growth that may be the result of maternal grooming.Sparse hair: * over 30% of mice lack hair at weaning with the remainder having sparse coats * coat remains sparse throughout lifeAbnormal hair follicle morphology: * sections of skin from hypotrichotic regions contain empty cysts in telogen follicles * cleft between the inner and outer root sheath * depilated hairs have a naked anagen bulb lacking the inner and outer root sheathAbnormal epidermal layer morphology: fewer desmosomes are identified in the interfolicular epidermis and unlike in wild-type mice, this number is further reduced after EGTA treatment.Hyperkeratosis: marked thickening of the stratum corneum on the palmoplantar surfaces of the paws.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"+/- x +/-","No","2012-03-14","Cryopreserved sperm"]
[4779,"wildtype control","129/Sv-Ifngr(WT)",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Control strain for conducting experiments with 129/Sv-Ifngr1<tm1Agt> strain",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[777,"ID3∆ ID1∆","B6.129-Idd3<-> Idd1<->",null,"Dominant","insulin dependent diabetes susceptibility 3","Idd3","Unknown","Idd-3","MGI:96405",{"$nulls":3},"3",{"$nulls":15},"Yes",{"$nulls":14},"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-18"]
[777,"ID3∆ ID1∆","B6.129-Idd3<-> Idd1<->",null,"Dominant","insulin dependent diabetes susceptibility 1","Idd1","Unknown","Idd-1","MGI:96400",{"$nulls":3},"17"]
[5187,null,"ENU18WT:020b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm"]
[5188,null,"ENU18WT:035b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm"]
[4919,"CD9 -/-","FVB/N.B6(129)-CD9<Bcx>/AusbApb",null,"Recessive","CD9 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<tm1Bcx>","MGI:2180795","6",{"$nulls":28},"Reduced female fertility: 40 - 50% of females fail to produce litters.Decreased litter size.Impaired fertilization: impaired sperm - egg fusion.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"No","2009-10-20","Cryopreserved sperm"]
[780,"Munc18c KO","C57BL/6-Stxbp3a<tm1Yt>",null,"Recessive","syntaxin binding protein 3A","Stxbp3a","Nil","MGC:86097, Munc-18c, Stxbp3, Sxtbp3","MGI:107362","targeted mutation 1, Yoshikazu Tamori","Stxbp3a<tm1Yt>","MGI:3528591","3",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.Decreased embryo size: at E13.5, homozygous mice are 17% shorter.Decreased birth body size: at birth pups are 30% shorterAbnormal cerebral cortex morphology:* contained poorly formed neural fibers and greater number of cellular components in the intermediate zone of the cerebral cortex.",null,"C57BL/6","No","No","Yes","No","No","Yes","Yes","Poor",{"$nulls":3},"No","2007-05-19"]
[8557,null,"hRhD L5 het ",null,"Dominant","murine RhD",{"$nulls":7},"Unknown",{"$nulls":16},"human RhD",{"$nulls":11},"human RhD expressed on murine RBC","human RhD expressed on murine RBC","C57BL/6","Yes","Unknown","Yes","Unknown","Unknown","Yes","No","Good","3",null,null,"No","2018-09-13","Cryopreserved sperm"]
[4994,"4AT6","ENU4AT:006",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[7340,"MommeD42","FVB/NJ-Brd1<MommeD42> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","bromodomain containing 1","Brd1","Unknown",null,"MGI:1924161","bromodomain containing 1; modifiers of murine metastable epiallele D42","Brd1<MommeD42>",null,"15","ENSMUSG00000022387","ENSMUST00000109381","Brd1-001",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~10.5 dpc)","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm"]
[6564,"iNOSΔ","B6.129P2-Nos2<tm1Lau>/JAusb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach","Nos2<tm1Lau>","MGI:1857228","11",{"$nulls":28},"Abnormal surfactant physiology:*Following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice.*Following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice.Abnormal circadian rhythm:*Mice display a more pronounced diurnal variation of sleep-wake activity.Abnormal sleep pattern:*Mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals.*Mice display a more pronounced diurnal variation of sleep-wake activity.*Mice spend less time in non-REM sleep during the dark phase.*During the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration.Abnormal brain wave pattern:*During non-REM sleep the absolute value of slow wave activity is increased.Abnormal inflammatory response:*Unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls.      Decreased inflammatory response:      *Fever in response to LPS injection is partially reduced compared to wild-type controls.      *The fever response to LPS is initiated but not sustained.      *However, fever in response to turpentine injection is not different from controls.",null,"unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[7644,null,"B6/Mrit-135904","B6/Mrit-135904","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7643,null,"SJL/ASAM<MRI115406>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07"]
[709,"NR4ML5","NOD.NOR-(D4Mit31-D4Mit310) Tg(ML5sHEL)5Ccg",null,"Recessive","insulin dependent diabetes susceptibility 9","Idd9","Nil","Idd-9","MGI:96411","NOR/LtJ","Idd9<NOR/LtJ>","MGI:3582457","4",{"$nulls":15},"No","transgene insertion 5, Christopher C Goodnow","mouse metallothionein I","High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03"]
[711,"NIHL","NOD-Tg(ILK3mHEL)3Ccg",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Pancreatic islet cells express membrane bound hen egg lysozyme.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03"]
[850,"Traf3 floxed","C57BL/6-Traf3<tm1Rbr>",null,"Dominant","Tnf receptor-associated factor 3","Traf3","Normal","CAP-1, CD40bp, CRAF1, LAP1","MGI:108041","targeted mutation 1, Robert Brink","Traf3<tm1Rbr>","MGI:3777324","12",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[8558,"ASD891:Sorghum","C57BL/6NCrlAnu-Nlrp9a<em1Anu>/AnuApb",null,"Recessive","NLR family, pyrin domain containing 9A","Nlrp9a","Unknown","D7Ertd565e, Nalp9a, Nalp-theta","MGI:2675292",{"$nulls":3},"7",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-13","Cryopreserved sperm"]
[4997,"ENU6AT:HELxTCR:line057:CBA:F2 ; Diablo","ENU6AT:57",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[5110,"KRN 007 Balb/b F2","KRN:007 BALB/b F2",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Maybe resistant to arthritis induced through serum transfer","Partially resistant to arthritis induced through serum transfer","BALB/b","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2010-05-07","Cryopreserved sperm"]
[2467,null,"B6.CBA-Tg(hGMCSF-KBM)457/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm"]
[1760,"Bcl-2-Bcl-w - double knockout","C57BL/6-Bcl2<tm1Dlo> Bcl2l2<tm1Sco>/Wehi",null,"Recessive","B-cell leukemia/lymphoma 2","Bcl2","Nil","Bcl-2","MGI:88138","targeted mutation 1, Dennis Y Loh","Bcl2<tm1Dlo>","MGI:2156165","1",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[1760,"Bcl-2-Bcl-w - double knockout","C57BL/6-Bcl2<tm1Dlo> Bcl2l2<tm1Sco>/Wehi",null,"Recessive","Bcl2-like 2","Bcl2l2","Nil","Bcl-w, bclw, Gtrgal2, Gtrosa41","MGI:108052","targeted mutation 1, Suzanne Cory","Bcl2l2<tm1Sco>","MGI:2158430","14"]
[7595,null,"SJL/ASAM<MRI40265>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","8",null,null,"No","2014-02-18","Cryopreserved sperm"]
[1855,null,"AID-cre-IRES-hCD2t",null,"Recessive",{"$nulls":25},"Cre recombinase","IRES - hCD2 ?",{"$nulls":13},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[5281,"NODGrzA/8.3","NOD.B6-Gzma<tm1Simn> Tg(TcraTcrbNy8.3)1Pesa",null,"Recessive","granzyme A ","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","granzyme A; targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"No","transgene insertion 1, Pere Santamaria","TCR alpha and beta enhancers",{"$nulls":10},"Mice may develop diabetes faster than wildtype.",null,"NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[5282,"NODGrzB/8.3","NOD.B6-Gzmb<tm1Ley> Tg(TcraTcrbNy8.3)1Pesa",null,"Recessive","granzyme B ","Gzmb","Nil","CCP-1/C11, CCP1, Ctla-1, Ctla1, GZB","MGI:109267","granzyme B; targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14",{"$nulls":15},"No","transgene insertion 1, Pere Santamaria","TCR alpha and beta enhancers",{"$nulls":10},"Mice may develop diabetes faster than wildtype.",null,"NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[7476,"Rhea","FVB/N-MommeD34 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant",null,null,"Reduced",null,null,"modifier of murine metastable epialleles, D34","MommeD34",null,"4",{"$nulls":15},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Mutant mice show a reduction in survival past weaning. Survivors at weaning are smaller than controls.Postnatal lethality: * few animals survive to weaning * normal litter size at birthDecreased body size: at weaning",null,"FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD34<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2013-11-13","Cryopreserved sperm"]
[4860,null,"C57BL/6-Tg(H2-K-huCD55,huCD59)/Apb",null,"Dominant",{"$nulls":25},"human CD55/CD59 dual construct","H2-K<b>","ubiquitous",{"$nulls":9},"Expression of membrane bound human CD55 and CD59 in all tissues on all cells.","Expression of membrane bound human CD55 and CD59 in all tissues on all cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[6268,"del511","C57BL/6-Fasl<tm1.1Ast>",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Nil","APT1LG1, CD178, CD95L, Fas-L, Tnfsf6","MGI:99255","Fas ligand (TNF superfamily, member 6); targeted mutation 1.1, Andreas Strasser","Fasl<tm1.1Ast>","MGI:4366050","1",{"$nulls":28},"Premature death:*Compared with wild-type mice and Fasl<gld> homozygotes.Immune system phenotype:*Mice mount a normal immune response to influenza.      Enlarged spleen      Increased circulating tumor necrosis factor level:      *At 12 to 20 weeks.      Enlarged lymph nodes      Increased immunoglobulin level         Increased IgA level         Increased IgE level         Increased IgG level            Increased IgG1 level            Increased IgG2a level            Increased IgG2b level         Increased IgM level      Defective cytotoxic T cell cytolysis:      *T cells are less efficient than wild-type cells at killing CH1 cells.      Increased susceptibility to systemic lupus erythematosus:      *62% of terminally ill mice exhibit systemic lupus erythematosus-like (SLE) autoimmune disease with cellular crescents, protein casts, and compliment in renal glomeruli unlike wild-type mice.      *Mice develop more severe SLE-like disease than Fasl<gld> homozygotes.      *By 57 weeks, 50% of mice develop fatal SLE-like autoimmune kidney disease compared with 15% of Fasl<gld> homozygotes.      Increased anti-nuclear antigen antibody level:      *Higher than in wild-type mice and Fasl<gld> homozygotes.         Increased anti-double stranded DNA antibody level:         *Higher than in wild-type mice and Faslgld homozygotes.      Glomerulonephritis:      *Mice develop SLE-like glomerulonephritis unlike wild-type mice and more frequently than Fasl<gld> homozygotes.      Dermatitis:      *30% of mice develop severe dermatitis with lesions on the ears and necks unlike wild-type mice.Increased histiocytic sarcoma incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.Increased liver tumor incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7255,"MLC:1IGF-1B_2B (Class 1Eb) ; SP1-IGF-1Eb","B6.FVB-Tg(Myl1-SP1/IGF1Ea)1Nros/MarpApb","FVB-Tg(Myl1-SP1/IGF1Ea)1Nros","Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain","skeletal muscle",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[6661,"McBride","C;B6-Myd88<tm1Aki>/ANU/Ausb",null,"Recessive","myeloid differentiation primary response gene 88 ","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira ","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":28},"Decreased B cell proliferation:*Splenocytes showed a defect in proliferation in response to the TLR4 ligand lipopolysaccharide (LPS), bacterial lipopeptide (BLP) that signals through the TLR1-TLR2 heterodimer, the TLR9 ligand unmethylated CpG DNA (CpG) and to the TLR7 ligand resiquimod (R-848).Abnormal dendritic cell physiology:*Dendritic cells produced barely detectable amounts of cytokines in response to LPS or CpG.*Dendritic cells mature only in response to LPS but not CpG.Abnormal macrophage physiology:*Activation of NF-kappaB, JNK, p38 and ERK in bone marrow derived macrophages was delayed in response to LPS and absent in response to BLP and CpG.Abnormal NK cell physiology:*NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection.Abnormal T cell physiology:*Thymocytes failed to proliferate in response to IL-1.      Abnormal NK T cell physiology:      *NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection.Abnormal cytokine secretion:*Type 1 IFN, IFNgamma and IL-12 p40 levels are decreased compared to C57BL/6 wild-type controls following sublethal viral infection.*IFNalpha was not secreted after infection with vesicular stomatitis virus (a ssRNA virus).Increased susceptibility to viral infection:*Viral loads and mortality are significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls.Decreased B cell proliferation:*Splenocytes showed a defect in proliferation in response to the TLR4 ligand lipopolysaccharide (LPS), bacterial lipopeptide (BLP) that signals through the TLR1-TLR2 heterodimer, the TLR9 ligand unmethylated CpG DNA (CpG) and to the TLR7 ligand resiquimod (R-848).",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[5945,"NfixCond/NestinCre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8559,"ENU41:157:Pycard:G3","C57BL/6NCrlAnu-Pycard<m1Anu>/AnuApb",null,"Recessive","PYD and CARD domain containing","Pycard","Unknown","9130417A21Rik, Asc, TMS-1","MGI:1931465",{"$nulls":3},"7",{"$nulls":30},"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-09-13","Cryopreserved sperm"]
[4924,"IL21 KO","NOD.B6-IL21<tm1Lex>",null,"Recessive","interleukin 21","Il21","Nil",null,"MGI:1890474","targeted mutation 1, Lexicon Genetics","Il21<tm1Lex>","MGI:3528994","3",{"$nulls":15},"No",{"$nulls":12},"Decreased germinal center B cell number:* the percentage of GC B cells that make up the total B cell population in the spleen of immunized mice is reduced by two-thirdsAbnormal CD4-positive T cell morphology:* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Abnormal spleen germinal center morphology:* the number of actively proliferating T cells found within GC is reduced 3- to 4- fold.* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Decreased spleen germinal center number:* there is a paucity of GC in the spleen of mice after immunization with sheep red blood cells (SRBC).Decreased CD4-positive T cell number:* Il-17+ CD4+ cells are absent from lamina propria and spleen in mutants.Abnormal T cell differentiation:* when naive TH cells are subjected to TH17 differentiation, a deficit in generation of Il-17-producing cells is observed with an increased number of Foxp3+ cells compared to wild-type.* one week after immunization with MOG peptide in CFA, restimulation of spleen cells with TPA or MOG peptide results in production of almost no Il-17 producing cells, showing impaired TH17 differentiation.Abnormal gamma-delta T cell morphology:*lamina propria and splenic TCRgd+ T cells show <10-fold decrease in Il-17-expressing cells compared to wild-type cells.Abnormal interleukin level:* CNS-infiltrating and splenic CD4+ T cells produce interferon gamma, in contrast to CD4+ T cells from controls which produce predominantly Il-17.",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-10-29"]
[3384,"Histamine receptor type 1 -/-","B6.129P2-Hrh1<tm1Wtn>","B6.129P2-Hrh1<tm1Wtn>","Recessive","histamine receptor H1","Hrh1","Nil","Bphs","MGI:107619","targeted mutation 1, Takeshi Watanabe","Hrh1<tm1Wtn>","MGI:2182945","6",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization. Increased responses to papain sensitisation.Increased brown adipose tissue amount:* the amount of brown adipose tissue at 48 weeks of age is increased relative to in wild-type mice.* insulin levels during a 4 week feeding schedule are lower than in mice fed ad libitum.* however, the levels of brown adipose tissue at 12 weeks of age is normal.Increased white adipose tissue amount: at 28 weeks of age, white adipose tissue is increased by 23%, 48% and 40% in the epididymmal, mesenteric and retroperitoneal fat pads, respectively, compared to wild-type mice.Decreased adipose tissue amount: unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased in adiposity.Increased fat cell size:* adipocytes in the epididymal white adipose tissue are larger than in wild-type mice at 48 weeks of age.* however, adipocyte size at 12 weeks of age is normal.Decreased circulating insulin level:* at 48 weeks of age, serum insulin levels are increased relative to in wild-type mice.* however, at 12 weeks of age serum insulin levels are normal.Increased circulating leptin level:* at 48 weeks of age, leptin levels are increased by 66% compared to in wild-type mice.* however, at 12 weeks of age leptin levels are normalIncreased circulating free fatty acid level:* at 48 weeks of age, free fatty acid levels are increased relative to in wild-type mice.* however, at 12 weeks of age free fatty acid levels are normal.Increased triglyceride level: mice exhibit 45% and 20% more triglycerides in the liver and skeletal muscle, respectively, compared to wild-type mice.Abnormal response/metabolism to endogenous compounds: following intracerebroventricular administration of 0.5 ug leptin or intraperitoneal injection of 50 ug of leptin, mice exhibit a smaller decrease in food consumption and body mass relative to wild-type.Decreased body weight:* during 4 week on a feeding schedule, mice fail to gain weight as do wild-type mice despite equivalent food consumption.* unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased body mass.* however, intracerebroventricular administration of methyl(2[2-pyridyl]ethyl)amine dyhydrochloride has no effect on mice.Increased body weight: after 28 weeks of age mice exhibit increased body mass relative to wild-type mice.Increased IgG level: following ovalbumin challenge, IgG1, IgG2a and IgG2b levels are increased relative to similarly treated wild-type mice.Increased IgM level: following ovalbumin challenge, IgM levels are increased relative to similarly treated wild-type mice.Decreased interferon-gamma secretion: antigen stimulation of splenocytes results in the production of less interferon-gamma compared to in similarly treated wild-type mice.Decreased interleukin-13 secretion: antigen stimulation of splenocytes results in the production of less IL-13 compared to in similarly treated wild-type mice.Decreased interleukin-5 secretion: antigen stimulation of splenocytes results in the production of less IL-5 compared to in similarly treated wild-type mice.Decreased inflammatory response:* following challenge with ovalbumin, mice fail to develop lung inflammation as do wild-type mice with fewer eosinophils and lymphocytes detected in the bronchoalveolar lavage.* however, mice exhibit normal B cell immune responses and inhalation of IL-4 or IL-13 induces lung inflammation.Abnormal behavior:* during passive avoidance testing, mice display more frequent urination and defecation and decreased movement compared to wild-type mice.* however, passive avoidance behavior is normal.Abnormal circadian rhythm:* mice exhibit increased locomotor activity during early portions of the light phase and decreased ambulation during the dark phase of a 12 hours light 12 hour dark cycle relative to similarly treated wild-type mice.* the ratio of ambulation during the light phase to total ambulation during 24 hours is increased compared to in wild-type mice.* however, total ambulation during a 24 hours period is normal.Decreased exploration in new environment: despite normal motor coordination, mice exhibit decreased ambulation and time of rearing for the first 30 minutes when placed in a new environment.Decreased vertical activity: mice rear less when placed in a new environment compared to wild-type mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-07-09","Cryopreserved sperm"]
[644,"ATM-pKZ1","C57BL/6-Tg(pKZ1) Atm<tm1Led>",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Unknown","C030026E19Rik","MGI:107202","ataxia telangiectasia mutated homolog (human); targeted mutation 1, Philip Leder","Atm<tm1Led>","MGI:1926875","9",{"$nulls":15},"Yes","β-galactosidase gene (lacZ) E. coli","chicken β-actin",{"$nulls":11},"Irradiated Atm heterozygous knock-out mice did demonstrate fewer inversions after exposure to 15 mGy X-radiation than the Atm normal pKZ1 mice.","C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25"]
[6900,"TGFbeta2","STOCK Tgfb2<tm1Doe>/MarpApb",null,"Recessive","transforming growth factor, beta 2","Tgfb2","Nil","Tgfb-2, Tgf-beta2","MGI:98726","transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman","Tgfb2<tm1Doe>","MGI:1888389","1",{"$nulls":29},"TGFb2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects (Sanford et al.,  1997.Development 124, 2659-2670).TGFb2 heterozygotes exhibit a 30% increase in nephron number (Sims-Lucas et al., Pediatr Res. 2008 Jun;63(6):607-12). ","Black Swiss/129/Ola mixed ","No","Unknown","Yes","No","Unknown","Yes","No","Good",null,null,"Heterozygotes are crossed to Wildtypes","No","2012-05-24","Cryopreserved sperm"]
[4999,"ENU9CAT:G1","ENU9CAT::HelxTCR:CBAxB6",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"No phenotype.Breeding from this G1 male lead to the 9CAT:051 pedigree.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-01","Cryopreserved sperm"]
[3535,null,"C57BL/6J-K<btm1>/JWehi",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894",{"$nulls":3},"17",{"$nulls":15},"Yes",{"$nulls":12},"These mice lack one MHC class I molecule, H-2K<b>. Since they still load and express H2D<b>, these mice are able to mount normal CD8 T cell responses to most pathogenes.  They do not show an immuno-compromised phenotype. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29"]
[6663,"MORTLOCK","BALB/c.B6-Il13<tm2Anjm>/ANU/Ausb",null,"Recessive","interleukin 13 ","Il13","Nil","Il-13 ","MGI:96541 ","interleukin 13; targeted mutation 2, Andrew NJ McKenzie ","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[8560,"ASD542:Busquets:C57Bl/6crlAnu","C57BL/6NCrlAnu-Bank1<em1Anu>/AnuApb",null,"Recessive","B cell scaffold protein with ankyrin repeats 1","Bank1","Unknown","A530094C12Rik","MGI:2442120",{"$nulls":3},"3",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-18","Cryopreserved sperm"]
[6685,"Young","B6.BALB/c-Il5<tm1Kopf>/Ausb",null,"Recessive","interleukin 5 ","Il5","Nil","Il-5 ","MGI:96557","interleukin 5; targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11",{"$nulls":28},"Enlarged placenta:*Knockout females have a significant increase in placenta size in matings with CBA males and the fetal:placental ratio is reduced.Prolonged estrous cycle:*Duration of oestrus in knockouts is moderately extended (5.6 days versus 5 days in controls).Abnormal mating receptivity:*Background Sensitivity: duration of mating interval to achieve mating with syngeneic (B6) versus allogeneic (CBA or BALB/c) males is increased.*After correction for male background, knockout females have significantly lower mating intervals than control females.Increased body weight:*Background Sensitivity: allogeneic matings produce larger pups than syngeneic pups; in CBA F1 pups, at weaning, female and male weights are increased 9.5 and 10%, while in C57BL/6 F1 pups, female and male weights at 6 weeks are increased by 7.9 and 12.2%.*Il5 deficient pups have an increased weight gain trajectory compared to wild-type.*Knockout pups are significantly larger than wild-type pups from birth to adulthood.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[6909,"BAC(A33:M2rtTA)","B6;129-Tg(Gpa33-rtTAS*M2)2/LudApb",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane), Gpa33","Mosaic activity in intestinal epithelium",{"$nulls":9},"Not described","The M2rtTA tet transactivator is expressed in the epithelium of the intestine and colon under the control of the intestine-specific A33 promoter. The expression/activety of the transactivator is mosaic, most likely due to stochastic transgene silencing. Approximately 1 to 5 crypts in the proximal small intestine express the transgene, fewer in the distral intestine and colon.","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-06-20","Cryopreserved sperm"]
[4843,null,"ENU6AT:008",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[68,null,"Socks",null,"Recessive",null,null,"Unknown",{"$nulls":5},"4",{"$nulls":15},"Yes",{"$nulls":12},"Dilute coat, white belly spot and \"socks\", small eyes. Unique phenotype for chromosome location, 34 potential genes in this region.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[7048,"FST KO","STOCK Fst<tm1Zuk>/MarpApb",null,"Recessive","follistatin","Fst","Nil",null,"MGI:95586","follistatin; targeted mutation 1, Martin M Matzuk","Fst<tm1Zuk>","MGI:1857467","13",{"$nulls":28},"Lifespan and health is affected.  FS knock-out mice are liveborn, but die within 6 hours of birth due to respiratory failure because of lung and chest muscle defects. These pups display growth retardation, defects of the hard palate and 13th rib, as well as whisker and tooth abnormalities and shiny taut skin.","Normal","C57BL/6 x 129 x FVB","No","No","Yes","No","No","Yes","No","Good",null,null,"Het x Het","No","2012-08-13","Cryopreserved sperm"]
[1936,null,"BALB/c-Tg(iFABPp-IL13)/AnuApb",null,"Semi-dominant",{"$nulls":25},"interleukin 13","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP","High",{"$nulls":9},"Restricted expression of IL13 transgene to intestine - duodenum and proximal jejunum.",null,"Balb/c ?","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-29","Cryopreserved sperm"]
[4076,null,"ENU6PH:016",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgG1 and IgE response following allergic challenge.",null,"B6 B10 Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[6664,"JOHNSON","BALB/c.B6-Tlr2<tm1Aki>/ANU/Ausb",null,"Recessive","toll-like receptor 2","Tlr2","Nil","Ly105","MGI:1346060","toll-like receptor 2; targeted mutation 1, Shizuo Akira","Tlr2<tm1Aki>","MGI:2178675","3",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[4847,null,"ENU6CAT:050",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[106,"4-1BBL -/-","B6.129Apb-Tnfsf9<tm1Thw>/Apb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 9","Tnfsf9","Nil","4-1BB ligand, 4-1BB-L, 4-1BBL, Cd137l, Ly63l","MGI:1101058","targeted mutation 1, Tania H Watts","Tnfsf9<tm1Thw>","MGI:2179297","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null allele exhibit increased susceptibility to viral infection and defective memory T cell activation.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[7648,null,"B6/Mrit-fech","B6/Mrit-fech","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[190,null,"S100 beta-dsRed",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes","dsRed","human S100 β gene",{"$nulls":10},"Cells expressing beta S100 express dsRed",null,"Quackenbush","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[7035,"Osx-Cre p53fl/fl pRbfl/fl","STOCK Rb1<tm3Tyj> Trp53<tm1Brn> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/StvApb",null,"Dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","transformation related protein 53; targeted mutation 1, Anton Berns","Trp53<tm1Brn>","MGI:1931011","11",{"$nulls":16},"Osx-Cre:GFP","Osterix (Sp7)","medium",{"$nulls":9},"Generate osteosarcoma (bone cancer)Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.","Slightly smaller, susceptible to malocclusion. Generate osteosarcoma if p53fl/+ but at long latency (1yr)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Cre+ve males to Cre-ve females, homozygous pRb and p53","No","2012-08-03","Cryopreserved sperm"]
[7035,"Osx-Cre p53fl/fl pRbfl/fl","STOCK Rb1<tm3Tyj> Trp53<tm1Brn> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Nil","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14"]
[5582,"129SvJ/Emx1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5162,"KRN 156","KRN:156",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":16},"transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis, no GPI autoantibodies in KRN/H2g7 model.",null,"C57BL/6J x BALB/b","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-06-28","Cryopreserved sperm"]
[4738,null,"B6;Cg-H2<k2> Cbl<tm1Ddlb> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb","B6;Cg-H2<k2> Cbl<tm1Ddlb> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd","Recessive","Casitas B-lineage lymphoma","Cbl","Unknown","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes","transgene insertion 3, Christopher C Goodnow","For Tg(ILK3mHEL)3Ccg: Rat insulin promoter",{"$nulls":10},"Defect in T cell function",null,"B10.BR-H2<k2> x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5","hom x hom","No","2009-04-20","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","For Tg(ILK3mHEL)3Ccg: Rat insulin promoter"]
[5195,null,"ENU18WT:017b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm"]
[7376,"ENU26:032:Birc6","C57BL/6NCrlAnu-Birc6<m1Anu>/AnuApb","C57BL/6NCrlAnu-Birc6<m1Anu>/AnuApb","Recessive","baculoviral IAP repeat-containing 6","Birc6","Unknown","A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik","MGI:1276108","baculoviral IAP repeat-containing 6; mutation 1, The Australian National University","Birc6<m1Anu>","MGI:5563506","17","ENSMUSG00000024073","ENSMUST00000024879","Birc6-201","14218","14475","C to T","ENSMUSE00001248145","71","4740","Glutamine to STOP",{"$nulls":4},"AAGCAACGGTTAAATGGGCTATGCTAGAACAAATCAGAAATCCTTCACCGTGCTTTAAAGA",{"$nulls":13},"Probably embryonic lethal","Unknown","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Good",null,"3","HET x HET","No","2013-07-17","Cryopreserved sperm"]
[1987,"Nkx2-3 KO","B6.129-Nkx2-3<tm1Rph>",null,"Recessive","NK2 transcription factor related, locus 3 (Drosophila)","Nkx2-3","Unknown","Nkx-2.3, Nkx2.3, tinman","MGI:97348","targeted mutation 1, Richard P Harvey","Nkx2-3<tm1Rph>","MGI:2448069","19",{"$nulls":15},"No",{"$nulls":12},"Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing.    30% of homozygotes die within the first 2 weeks due to acute intestinal malabsorptionsurviving homozygotes recover rapidly, are fertile, and appear generally healthy as adults.",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05"]
[5193,null,"ENU18WT:025b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm"]
[5194,null,"ENU18WT:036a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm"]
[7649,null,"B6/Mrit-pf","B6/Mrit-pf","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7036,"zeta-BALB/c 390 ; 14-3-3 zeta deficient (Line 390)","C.129-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","BALB/c","Yes","No","Yes","Yes","No","Yes","Yes","Good","10",null,"het x het","No","2012-08-06","Cryopreserved sperm"]
[6792,"A33CreERt2/LacZ13 (ME-223)","STOCK Tg(Gpa33-cre/ERT2) Tg(Pgk1-lacZ)13Vmel/LudApb",null,"Dominant",{"$nulls":25},"cre recombinase","glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","Mixed","No","Unknown","Yes","No","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-01-18","Cryopreserved sperm"]
[{"$nulls":30},"cre recombinase","glycoprotein A33 (transmembrane)"]
[7080,"Momme D40","FVB/NJ-Uhrf1<MommeD40> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","ubiquitin-like, containing PHD and RING finger domains, 1","Uhrf1","Unknown","ICBP90, Np95","MGI:1338889","ubiquitin-like, containing PHD and RING finger domains, 1; modifier of murine metastable epialleles, D40","Uhrf1<MommeD40>",null,"17",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Lethalhomozygous die E10.5","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD40<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-13","Cryopreserved sperm"]
[6665,"Big Blue","C57BL/6-Tg(TacLIZa)A1Jsh/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion A1, Jay M Short",null,"30 copies of the transgene",{"$nulls":11},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[697,"TAG (C3SV40T)","FVB/N-Tg(C3-1-TAg)cJeg",null,"Dominant",{"$nulls":25},"transgene insertion C, Jeffrey E Green","rat prostatic binding protein C3 promoter (Pbpc3)",{"$nulls":11},"Mammary gland hyperplasia: at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice,hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice.Abnormal prostate physiology:prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia.Increased tumor incidence:some mice exhibit mixed tumors of the sweat glands and occasional nasal proliferative or neoplastic lesions develop from the nasal turbinate epithelium unlike in wild-type mice.Adenocarcinoma:at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral and bulbourethral glands unlike in wild-type miceMammary adenocarcinoma:by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice.at 6 months, 10% of female mice exhibit lung metastasis.adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice.Prostate adenocarcinoma:at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice.after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice.the number of apoptotic cells in the prostate is greater than in wild-type mice.at 7 months in the ventral prostate and 11 months in the dorsolateral prostate.however, no metastasis is observed.Prostate intraepithelial neoplasia:at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice.low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice.at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice.high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice.numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice.the number of apoptotic cells in the prostate is greater than in wild-type miceat 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice.at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice.PIN lesions increase with age.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-01"]
[5196,null,"ENU18WT:022a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm"]
[5284,"B6.CD39.Tg.1079-4.A2AR.KO","C57BL/6-Adora2a<tm1Jfc> Tg(H2-K<b>-Entpd1)",null,"Recessive","adenosine A2a receptor","Adora2a","Nil","A2a, Rs, A2AAR, A2aR, AA2AR","MGI:99402","adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen","Adora2a<tm1Jfc>","MGI:2155985","10",{"$nulls":15},"No","human CD39","H2-K<b>",{"$nulls":10},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[1513,"eNOSTg","B6.Cg-Tg(Edn1-NOS3)22Yky/Apb","B6.Cg-Tg(Edn1-NOS3)22Yky/Apb","Dominant",{"$nulls":25},"transgene insertion 22, Mitsuhiro Yokoyama","mouse Edn1","Active in vascular wall",{"$nulls":9},"Hypotension. Elevated cGMP, plasma nitrate and nitrite levels.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","7",null,null,"No","2007-07-04","Cryopreserved sperm"]
[3444,"TCR transgenic - CL4","BALB/c-Tg(TcraCl4,TcrbCl4)1Shrm/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1, Linda Sherman","Tcra-V promoter, the immunoglobulin heavy-chain enhancer E(H)",{"$nulls":10},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice. CL4 - Transgenic mice are viable, fertile, normal in size, normoglycemic and do not display any gross physic or behavioral abnormalities.The TCR expressed from this transgene is specific for influenza virus A/PR/8 hemagglutinin (HA) in the context of the MHC class I molecule H2-Kd.  Both thymic and periperal T-cell populations are skewed toward CD8+ cells.  The majority of thymocytes and virtually all CD8+ T cells in lymph nodes express the transgenic TCR beta chain.  About 40% of peripheral blood CD8+ T cells react with the HA peptide presented by H2-Kd.  ",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-17"]
[5285,"B6.CD39.Tg.1079-4.CD73.KO","C57BL/6-Nt5e<tm1Lft> Tg(H2-K<b>-Entpd1)",null,"Recessive","5' nucleotidase, ecto","Nt5e","Nil","CD73, ecto-5'-nucleotidase, Nt5","MGI:99782","5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson","Nt5e<tm1Lft>","MGI:3522017","9",{"$nulls":15},"No","human CD39","H2-K<b>",{"$nulls":10},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[3471,"C3G genetrap","129-Rapgef1<Gt(pGT1.8geo)5Pgr>/Wehi",null,"Recessive","Rap guanine nucleotide exchange factor (GEF) 1","Rapgef1","Nil","4932418O06Rik, C3G, Grf2","MGI:104580","Rap guanine nucleotide exchange factor (GEF) 1; gene trap 5, Peter Gruss ","Rapgef1<Gt(pGT1.8geo)5Pgr>","MGI:2445403","2",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a gene trap allele exhibit embryonic lethality, altered neuroepithelium morphology, embryonic and extra-embryonic vascular defects, and reduced cell migration and adhesion.","Normal","129/SvPas","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[7087,"Bim Des RAG","B10.BR.(Cg)-H2<k> Bcl2l11<tm1.1Ast>/Wehi Rag1<tm1> Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd/Apb",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"Yes","transgene insertion 10395, Bernd Arnold",{"$nulls":11},"Similar phenotype as in C57BL/6 mice (Increased numbers of lymphoid and myeloid cells.)Bim-/- females are bad mothers and should not be used for breeding unless necessary.  Bim -/-:  blood - increased lymphocytes (B + T cells), granulocytes & monocytes. - decreased platelets - Increased serum Ig. Des-TCR onto Bim-deficient background can be generated but problems to generate RAG-/- mice. This strain is thus HETEROZYGOUS for RAG deficiency","Unknown","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"Yes","2012-09-20","Cryopreserved sperm"]
[7087,"Bim Des RAG","B10.BR.(Cg)-H2<k> Bcl2l11<tm1.1Ast>/Wehi Rag1<tm1> Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd/Apb",null,"Recessive","recombination activating gene 1","Rag1","Normal","Rag-1","MGI:97848",{"$nulls":3},"2"]
[6279,"FOX03","B6.129-Foxo3<tm1Nmt>",null,"Recessive","forkhead box O3","Foxo3","Nil","1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a","MGI:1890081","forkhead box O3; targeted mutation 1, Noboru Motoyama","Foxo3<tm1Nmt>","MGI:3719789","10",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*All mice die by 4 weeks after injection with the cell cycle specific myelotoxic drug 5-FU in contrast over 60% of wild-type controls survived.Hematopoietic system phenotype:*Unlike red blood cells, the numbers of white blood cells and platelets and the morphology or myeloid and lymphoid cells are similar to controls.*Proliferation and differentiation of hematopoietic progenitors in the bone marrow are similar to controls.      Decreased erythrocyte cell number      Increased mean corpuscular hemoglobin      Increased mean corpuscular volume      Reticulocytosis      Abnormal hematopoietic stem cell morphology:      *Colony formation in long term culture experiments is severely impaired reflecting a defect in hematopoietic stem cell function.      *Competitive repopulation assays suggest a defect in hematopoietic stem cell self renewal.      *The proportion of cells in G0 is reduced suggesting a defect in quiescence maintenance.      *Reactive oxygen species are elevated.      *Colony formation in short term cultures is reduced for cells from aged mice but not for cells from young mice.         Decreased hematopoietic stem cell number:         *In some aged mice but not in young mice.Female infertility",null,"C57BL/6 X 129/sv","Yes","No","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5434,"Meio1","Meio1",null,"Recessive","unknown","unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Male infertility due to meiotic arrest in male germ cells.","normal","mixed background (C57BL/6J and CBA)","Yes","Yes","Yes","Yes","No","Yes","Yes","Good",{"$nulls":3},"No","2011-02-15","Cryopreserved sperm"]
[4936,"Cathepsin-S Knockout","C6;SJL-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-24"]
[7093,"F/F x Tlr2; gp130Y757F x Tlr2","STOCK Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop gastric and inflammation and tumours, as well as splenomegaly and lymphadenopathy.","If the mice are heterozygous for the gp130 knock-in mutation (F+) then the mice appear normal. ","C57BL/6 x 129Sv x BALB/c","Yes","No","Yes","Yes","Yes","Yes","No","Good","10",null,"heterozogous x homozygous","No","2012-09-26","Cryopreserved sperm"]
[7093,"F/F x Tlr2; gp130Y757F x Tlr2","STOCK Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","toll-like receptor 2","Tlr2","Nil","Ly105","MGI:1346060","toll-like receptor 2; targeted mutation 1, Shizuo Akira","Tlr2<tm1Aki>","MGI:2178675","3",{"$nulls":15},"No"]
[349,"PKZ1","C57BL/6-pKZ1",null,"Dominant",{"$nulls":25},"β-galactosidase gene, E. coli (reverse orientation)  flanked by the mouse Vκ21C and Jκ5 immunoglobulin recombination signal sequences","chicken β-actin promoter complex",{"$nulls":10},"Normal.When an inversion event occurs, facilitated by the mouse recombination signal sequences, the lacZ gene is brought into correct juxtaposition with respect to the promoter complex and expression of the E. coli β-galactosidase message can occur (Fig 1). The E. coli β-galactosidase protein can then be detected in tissues in the animals by staining with the chromogenic substrate X-gal. Cells that undergo inversion events exhibit blue staining. The number of inversion events is determined by the ratio of the number of blue staining cells to the total number of cells counted. Inversion events have been detected in a wide range of pKZ1 tissues, with most studies to date concentrating on spleen tissue.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"pKZ1 mice x C57BL/6","No","2006-09-29"]
[7099,"Fst-oEX","B6;D2-Tg(KRT14-Fst)/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, ","human keratin-14 (K14)",{"$nulls":10},"unknown","only one copy required to demonstrate phenotype.Mice demonstrate larger ears, longer tails, reduced body weight, mild dermal and epidermal atrophy and delayed wound healing","B6D2F2","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Het mouse  x wt mouse","No","2012-10-01","Cryopreserved sperm"]
[3940,"C3H.DUB/3","C3Arc.MOLD-Oas1b<Flv-mr>/Arc","C3Arc.MOLD-Oas1b<Flv-mr>Arc","Dominant","2'-5' oligoadenylate synthetase 1B","Oas1b","Normal","Flavivirus resistance, Flv, L1, Mmu-L1, Oias-2, Oias2, Wnv","MGI:97430","minor flavivirus resistance","Oas1b<Flv-mr>","MGI:1857802","5",{"$nulls":15},"No",{"$nulls":12},"Minor resistance to Flavivirus infection.Flv<mr> Phenotype – Resistance to infections by Flaviviruses.Tlr4 Phenotype – Toll 4 receptor is responsive to LPS injection.","Flv<mr> Phenotype – dominant phenotype, heterozygotes are resistant to infection.Tlr4 phenotype is dominant and heterozygous mice show responsiveness to LPS.","C3H/HeJARC","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,"brother x sister","No","2008-10-17"]
[5323,"NfiB Conditional","B6.129-Nfib<tm2Rmg>/Apb",null,"Dominant","nuclear factor I/B","NFib","Reduced",null,"MGI:103188","nuclear factor I/B; targeted mutation 2, Richard M Gronostajski","Nfib<tm2Rmg>","MGI:5052268","4",{"$nulls":28},"Apparently normal. Viable as homozygous mice when not crossed to a Cre expressing line.","Apparently normal. Viable as heterozygous mice when not crossed to a Cre expressing line.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-17","Cryopreserved sperm"]
[6349,"NPYcre","B6.Cg-Npy<tm1(cre)Tkar>/Ausb",null,"Recessive","neuropeptide Y ","Npy","Nil","0710005A05Rik ","MGI:97374","neuropeptide Y; targeted mutation 1, Tim Karl ","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":28},"Increased anxiety-related response:*Increased levels of anxiety-related behaviors are detected across different test paradigms with males having more pronounced behaviors.*Males have about a two-thirds reduction and females have a third to a half reduction in time spent in the center of an open field.*Male mice but not female mice show a reduced amount of time in the open arm of an elevated maze test.*Mutant males spend less time in the aversive illuminated compartment of a light-dark test with the ratio of distance traveled in lit areas (to total distance traveled) being half that of sex-matched controls.Decreased exploration in new environment:*vertical activities in a new environment are reduced by two-thirds.*Similar results are obtained in an elevated maze test.Decreased vertical activity:*Vertical activities of mutant mice are reduced by two-third in open field testsHypoactivity:*Mice of both sexes have reduced motor activity in an open field tests(371.1 movements vs. 585.5 movements for males).*Both mutant and wild-type female mice have higher locomotion than male mice of the same genotype (479.8 movements vs. 630.7 movements for wild-type females).*Similar results occur in light-dark field tests.*Mutant mice also have longer resting duration time in an open field test (393.3 seconds vs. 347.2 s in wild-type females).*Male mice have increased resting times compared to female mice (462.7s vs. 381.6s).*Similar resting results occur in light-dark field tests.Increased defecation:*Female mice have increased rates of defecation in elevated maze tests (2.8 vs. 0.1 in controls)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3597,null,"C57BL/6-Cd36<tm1Mfe>",null,"Recessive","CD36 antigen","Cd36","Nil","FAT, fatty acid translocase, Scarb3","MGI:107899","targeted mutation 1, Maria Febbraio","Cd36<tm1Mfe>","MGI:1931790","5",{"$nulls":15},"Yes",{"$nulls":12},"Homozgyous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart.  CD36 null mice have elevated fasting levels and cholesterol, triacylglycerol & non-esterfied free fatty acids and lower fasting serum glucose levels.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06"]
[6353,"IL27ra","B6.Cg-IL27ra<tm1Fjs>/Ausb",null,"Recessive","interleukin 27 receptor, alpha","Il27ra ","Nil","IL-27R, Tccr, WSX-1 ","MGI:1355318 ","interleukin 27 receptor, alpha; targeted mutation 1, Frederic J de Sauvage","Il27ra<tm1Fjs>","MGI:3525439","8",{"$nulls":28},"Increased lymphocyte cell number:*Increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type.Abnormal T-helper 1 physiology:*amount of interferon-gamma production was decreased per lung-derived CD4 T cell and per antigen-specific CD4 T cell, but not in spleen-derived CD4 T cell, after M. tuberculosis infection.Decreased susceptibility to bacterial infection:*Improved control of Mycobacterium tuberculosis growth and improved reduction of bacterial burden in the lungs, spleen, and draining lymph node.Increased lymphocyte cell number:*Increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7104,"MT-1/II KO","B6.129-Mt1<Rch> Mt2<Rch>/SaApb",null,"Recessive","metallothionein 1","Mt1","Nil","Mt-1, MT-I","MGI:97171","metallothionein 1; targeted mutation 1, Anna E Michalska","Mt1<tm1Rch>","MGI:2668454","8",{"$nulls":28},"Increased circulating alanine transaminase level: in acetaminophen-treated miceAbnormal ion homeostasis:  * increased cadmium sensitivity * take up a hunched back posture, ruffed coat and display general lethargyAbnormal lipid homeostasis: acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice.Increased sensitivity to xenobiotic induced morbidity/mortality: mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice.Increased physiological sensitivity to xenobiotic: * mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice * acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice * hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells * however, acetaminophen metabolism is normalIncreased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.Abnormal hepatocyte morphology: hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells.Hepatic necrosis: in acetaminophen-treated micetumorigenesis.Increased tumor incidence: 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks).Increased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2012-10-09","Cryopreserved sperm"]
[7104,"MT-1/II KO","B6.129-Mt1<Rch> Mt2<Rch>/SaApb",null,"Recessive","metallothionein 2","Mt2","Nil","Mt-2, MT-II","MGI:97172","metallothionein 2; targeted mutation 1, Anna E Michalska","Mt2<tm1Rch>","MGI:2668455","8"]
[7663,null,"ENU17China14 ",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Reduced numbers of marginal zone B cells","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-04-11","Cryopreserved sperm"]
[3487,null,"C57BL/6-IL1rap<tm1Roml>",null,"Recessive","interleukin 1 receptor accessory protein","Il1rap","Unknown","6430709H04Rik, IL-1R AcP, IL-1RAcP","MGI:104975","interleukin 1 receptor accessory protein; targeted mutation 1, Mark A Labow ","Il1raptm1Roml","http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3262","16",{"$nulls":15},"Yes",{"$nulls":12},"Normal.Decreased IL-6 secretion in response to IL-1 injections",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5432,"11B6115b","ENU11B6:115b",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to TB",null,"C57BL/6J x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"6","Sib x sib","No","2011-02-14","Cryopreserved sperm"]
[713,"NID5ML5","NOD-Idd5<C57BL/10> Tg(ML5sHEL)5Ccg",null,"Dominant","insulin dependent diabetes susceptibility 5","Idd5","Unknown","Idd-5","MGI:96407","C57BL/10","Idd5<C57BL/10>","MGI:2389023","1",{"$nulls":15},"Yes","transgene insertion 5, Christopher C Goodnow",null,"High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03"]
[1740,"Aire knockout 384","C57BL/6-Aire<tm1Scot>/Wehi",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Unknown",null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. An increase in the number of activated T cells was evident, and autoantibodies against several organs were detected. At the histological level, lymphocytic infiltration of several organs indicated the development of autoimmunity, although symptoms were mild.Male infertility.They are  immuno-compromised.  They suffer mild  auto-immune disease and the immune response to some infectious agents is impaired.  The -/- C57BL/6 LINE of aireKO mice suffers very mild autoimmune symtoms, particularly in the eye and possibly in the epididymis.  Other strains may have more severe autoimmune symptoms.  Fertility of homozygous males is variable. ","Hetrozygotes are apparently unaffected. ","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[5287,"B6.CD73KO/B6.A2ARKO","C57BL/6-Nt5e<tm1Lft> Adora2a<tm1Jfc>",null,"Recessive","5' nucleotidase, ecto","Nt5e","Nil","CD73, ecto-5'-nucleotidase, Nt5","MGI:99782","5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson","Nt5e<tm1Lft>","MGI:3522017","9",{"$nulls":15},"No",{"$nulls":12},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[5287,"B6.CD73KO/B6.A2ARKO","C57BL/6-Nt5e<tm1Lft> Adora2a<tm1Jfc>",null,"Recessive","adenosine A2a receptor","Adora2a","Nil","A2a, Rs, A2AAR, A2aR, AA2AR","MGI:99402","adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen","Adora2a<tm1Jfc>","MGI:2155985","10",{"$nulls":15},"No"]
[1551,null,"BALB/c-IL13<tm2Anjm> Tg(iFABPp-IL9)",null,"Recessive","interleukin 13","Il13","Unknown","Il-13","MGI:96541","targeted mutation 2, Andrew NJ McKenzie","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":15},"Yes","interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP  linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences).","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[5290,"CBA/B6/129sv-TgN(HUEPCR)-PAR1 KO","CBA;B6;129-F2r<tm1Ajc> Tg(H2-K<b>-EPCR)",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No","human protein C receptor, endothelial","H2-K<b>","Strong, endothelial cells and neutrophils",{"$nulls":9},"Unknown",null,"C57BL/6 x CBA","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[3561,null,"C57BL/6-Mnt<fl>",null,"Recessive","max binding protein","Mnt","Normal","Rox","MGI:109150",{"$nulls":3},"11",{"$nulls":15},"No","LoxP, Hygro",{"$nulls":11},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01"]
[5291,"B6.EPCR/TBM.Tg.","CBA;B6-Tg(H2-K<b>-TBM) Tg(H2-K<b>-EPCR)",null,"Recessive",{"$nulls":25},"Thrombomodulin","H2-K<b>","Strong, endothelial cells and neutrophils",{"$nulls":9},"Unknown",null,"CBA x C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[{"$nulls":30},"Thrombomodulin","H2-K<b>","Strong, endothelial cells and neutrophils"]
[6203,"IFNg","B6.129S7-Ifng<tm1Ts>/J",null,"Recessive","interferon gamma","Ifng    ","Nil","Ifg, IFN-gamma","MGI:107656","interferon gamma; targeted mutation 1, Timothy Stewart ","Ifng<tm1Ts>","MGI:1857184","10",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls.Increased susceptibility to bacterial infection induced morbidity/mortality:*Die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis.Increased susceptibility to parasitic infection induced morbidity/mortality:*Most mice die by 9 days after infection with 1x10<6> Cryptosporidium parvum oocysts.Immune system phenotype:*Do not exhibit defects on either IgE isotype switch or IgE production.      Stomach inflammation:      *5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice.      Increased leukocyte cell number:      *Following infection with BCG.         Increased NK T cell number:         *Unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers.         Increased granulocyte number:         *In the blood, bone marrow and spleen following infection with BCG.         Increased monocyte cell number:         *Following infection with BCG.      Abnormal spleen morphology         Abnormal spleen red pulp morphology:         *Following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue.         Enlarged spleen:         *Develop splenomegaly after infection with BCG.         Abnormal spleen white pulp morphology:         *Following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes.         Pale spleen:         *Spleens become paler as BCG infection proceeds.      Abnormal circulating cytokine level:      *Increase in circulating levels of CSF3 after infection with BCG especially in moribund mice.         Increased circulating interleukin-6 level:         *Following infection with BCG.      Enlarged mesenteric lymph nodes:      *In C. parvum infected mice.      Abnormal dendritic cell physiology:      *Increase in IL12 and decrease in IL10 secretion following LPS stimulation.         Abnormal Langerhans cell physiology:         *Enhancement in hapten induced Langerhan cell migration to the draining lymph nodes.         Abnormal dendritic cell antigen presentation:         *Dendritic cells show a greater ability to stimulate T cell proliferation in vitro.         Abnormal dendritic cell chemotaxis:         *Enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro.         *Enhancement in LPS induced dendritic cell migration to the spleen.      Abnormal macrophage recruitment:      *5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice.      Abnormal type IV hypersensitivity reaction:      *In OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls.         Increased susceptibility to type IV hypersensitivity reaction:         *Display a more severe delayed type hypersensitivity reaction in response to sheep IgG.      Abnormal humoral immune response:      *The magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced.      *However, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels.         Abnormal immunoglobulin level:         *IgG responses are restricted to IgG1 and IgG2b.      Abnormal cytokine secretion:         Decreased interferon-gamma secretion:         *Splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation.         Decreased interleukin-10 secretion:         *Splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen.         *By bone marrow dendritic cells following LPS stimulation.         Increased interleukin-12 secretion:         *By bone marrow dendritic cells following LPS stimulation.         Increased interleukin-4 secretion:         *Splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen.      Abnormal immune tolerance:      *Oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen.      Glomerulonephritis:      *Increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes.      Increased susceptibility to bacterial infection:      *Following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter.      *Following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen.      Increased susceptibility to parasitic infection:      *Background Sensitivity: mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not.      *Background Sensitivity: in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlarged.      Decreased length of allograft survival:      *Decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb.      *Only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice.Increased fear-related response:*Background Sensitivity: increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background.*Prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls.*Make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls.Abnormal response to new environment:*Background Sensitivity: increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background.*The number of rearings is decreased in a novel environment.*Initial locomotor activity is decreased; however, overall distance traveled is not different from controls.Decreased vertical activity:*In a novel environment.Abnormal redox activity:*Unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes.Abnormal urine homeostasis:*1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls.      Albuminuria:      *Increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis.Abnormal nitric oxide homeostasis:*Unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels.Abnormal response to injury:*Decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury.*Fibrotic lesions are sometimes seen after injury.*5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice.      Decreased susceptibility to injury:      *Following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury.      *However, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls.Skeletal muscle fibrosis:*Fibrotic lesions are sometimes seen after injury.Abnormal muscle regeneration:*Decrease in the number and area of regenerating fibers 5 and 10 days after injury.*Fibrotic lesions are sometimes seen after injury.*However, prior to injury no difference in muscle fiber morphology are detected.Stomach inflammation:*5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice.Extramedullary hematopoiesis:*Following infection with BCG.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[1779,"NOD.B6 Idd11A","B6.NOD-Idd11<NOD/ShiLt>/Wehi",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11; NOD/ShiLt","Idd11NOD/ShiLt>","MGI:3036810","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes. It is best to best to begin monitoring development of glycosuria at weekly intervals starting at 10 wks of age.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[6352,"Y1fCOL3.6?","B6.Cg-Npy1r<tm1wpg> Tg(Col1a1-cre)2Bek/Ausb",null,"Dominant","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","neuropeptide Y receptor Y1; targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":16},"transgene insertion 2, Barbara E Kream","rat Col1a1 promoter",{"$nulls":10},"Increased diameter of femur:*With an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter.Increased bone mineral content:*Whole body and lumbar vertebraeIncreased bone mineral densityIncreased bone trabecula numberIncreased trabecular bone thicknessAbnormal bone ossification:*Bone formation rate in cancellous and cortical bone is increased compared to in wild-type mice.Abnormal osteoblast physiology:*Mice exhibit increased osteoblast activity compared to in wild-type mice.Increased bone strengthIncreased diameter of femur:*With an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter.",null,"Mixed - mice","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[1814,"SOCS2 / Ghrhr","Un-Socs2<tm1Wehi> Ghrhr<lit>/Wehi",null,"Recessive","suppressor of cytokine signaling 2","Socs2","Nil","CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2","MGI:1201787","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs2<tm1Wehi>","MGI:1934557","10",{"$nulls":15},"Yes",{"$nulls":12},"The Ghrhr<lit> mutation deletes the SOCS2 -/- phenotype.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[1814,"SOCS2 / Ghrhr","Un-Socs2<tm1Wehi> Ghrhr<lit>/Wehi",null,"Recessive","growth hormone releasing hormone receptor","Ghrhr","Nil","Ghrfr","MGI:95710","little","Ghrhr<lit>","MGI:1856425","6"]
[115,"Ben","C57BL/6JSfdAnu-Tg(IghelMG6)6Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IghelMG6)6Ccg/AnuApb","Dominant",{"$nulls":25},"Low copy number (2H, 2L) anti-HEL transgenic for a chimeric Ig protein (IgM extracellular, and IgG transmembrane and intracellular domains)",null,"High",{"$nulls":9},"B cells express immunoglobulin specific for Hen Egg Lysozyme.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16",null,"No","2006-02-06","Cryopreserved sperm"]
[783,"DYN KO","B6.129-Pdyn(tm1(cre)Czer",null,"Recessive","prodynorphin","Pdyn","Nil","Dyn","MGI:97535","targeted mutation 1, Christoph Schwarzer","Pdyn<tm1(cre)Czer>","MGI:3715202","2",{"$nulls":15},"No",{"$nulls":12},"Dyn-/- mice were no different from wild types with regards to body weight and basaland fasting-induced food intake, but fecal output was increased – suggestingdecreased nutrient absorption – and they had significantly less white fat andlost more weight during a 24-hour fast. The neuroendocrine and thermalresponses to fasting were at least as pronounced in Dyn-/- as in wild types, andthere was no stimulatory effect of dynorphin knockout on 24-hour energyexpenditure (kcal heat produced) or physical activity. However, Dyn-/- miceshowed increased circulating concentrations of 3,4-dihydroxyphenlacetic acidand 3,4-dihydroxyphenylglycol, suggesting increased activity of sympatheticnervous system. The respiratory exchange ratio of male but not female Dyn-/-mice was reduced, demonstrating increased fat oxidation. Interestingly,expression of the orexigenic acting neuropeptide Y in the hypothalamic arcuatenucleus was reduced in Dyn-/- mice. However, fasting-induced increases in preprodynorphinexpression in the arcuate nucleus, the paraventricular nucleusand the ventromedial hypothalamus but not the lateral hypothalamus wereabolished by deletion of Y1 but not Y2 receptors. Ablation ofdynorphins results in increases in fatty acid oxidation in male mice, reductionsin adiposity and increased weight loss during fasting",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","8",null,null,"No","2007-05-19"]
[784,"NPY KO","B6.129-Npy<tm1(cre)Tkar",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"No",{"$nulls":12},"A significant reduction of food intake after 24 or 48 h fasting.High fat diet did not appear to influence bodyweight or food intake in the NPY knockout young adult NPY knockout mice is the increase (≈30%) in mild seizures when exposed to an unfamiliar environmentsignificant increase in an anxiogenic-like phenotype of these mice NPY−/− mice exhibit significant higher ethanol consumption and lower sensitivity to ethanol compared to control mice with NPY-overexpressing mice showing opposite effects The lack of NPY in NPY−/− mice causes an exaggerated autotomy, a self-mutilation behavior possibly related to pain sensation, in agreement with the analgesic effects of NPY.Increased anxiety-related response:* increased levels of anxiety-related behaviors are detected across different test paradigms with males having more pronounced behaviors.* males have about a two-thirds reduction and females have a third to a half reduction in time spent in the center of an open field.* male mice but not female mice show a reduced amount of time in the open arm of an elevated maze test.* mutant males spend less time in the aversive illuminated compartment of a light-dark test with the ratio of distance traveled in lit areas (to total distance traveled) being half that of sex-matched controls.Decreased exploration in new environment:* vertical activities in a new environment are reduced by two-thirds.* similar results are obtained in an elevated maze test.Decreased vertical activity:* vertical activities of mutant mice are reduced by two-third in open field tests.Hypoactivity:* mice of both sexes have reduced motor activity in an open field tests(371.1 movements vs. 585.5 movements for males)* both mutant and wild-type female mice have higher locomotion than male mice of the same genotype (479.8 movements vs. 630.7 movements for wild-type females)* similar results occur in light-dark field testsmutant mice also have longer resting duration time in an open field test (393.3 seconds vs. 347.2 s in wild-type females)* male mice have increased resting times compared to female mice (462.7s vs. 381.6s).* similar resting results occur in light-dark field testsIncreased defecation:* female mice have increased rates of defecation in elevated maze tests (2.8 vs. 0.1 in controls).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[785,"PYY KO","B6.129-Pyy<tm1(cre)Hhzg>",null,"Recessive","peptide YY","Pyy","Nil",null,"MGI:99924","targeted mutation 1, H Herzog","Pyy<tm1(cre)Hhzg>","MGI:3664105","11",{"$nulls":15},"No","Cre recombinase",{"$nulls":11},"Abnormal body weight:* male mutants do not show significant changes is body weight on a high-fat diet from 4 weeks of age compared to wild type mice.Increased body weight:* on a normal chow diet, female mutants from 4 to 28 weeks of age have significantly increased body weights compared to wild type (area under curve (AUC): wild type, 505g/24 weeks vs Pyy-null, 554g/24 weeks).* females show a marked increase in body weight between 15 and 28 weeks (AUC: mutants 344 g/15-28 weeks; wild type 307.6 g/ 15-28 weeks).Increased susceptibility to age related obesity:* female mutants, not males, develop late-onset obesityIncreased lean body mass:* both 14-week-old male and female mice show a significant increase in whole body lean mass.Increased circulating insulin level:* male and female chow-fed animals show higher serum insulin levels than controls during glucose tolerance test period.* fasting and glucose-induced serum insulin levels are elevated significantly above those observed in wild type mice fed a high fat diet (mutant >200 pmol/l/min vs wild type ~150 pmol/l/min).Increased circulating insulin-like growth factor I level:* male mutants have significantly higher serum levels of IGF-1 when fed a normal chow dietIncreased circulating testosterone level:* in regular chow-fed male mutants, serum testosterone levels are elevated to a statistically significant degree.Impaired glucose tolerance:on a high-fat diet, male mutants are less glucose-tolerant than wild type but difference disappears when data are normalized for bodyweight.Increased white adipose tissue amount:weight of all white fat adipose tissue deposits in females are increased at 28 weeks of age, consistent with increase in body fat.Decreased adipose tissue amount:* females show a decrease in whole body fat mass at 14 weeksIncreased adipose tissue amount:* chow-fed females show a significant 50% increase in fat mass at 28 weeks of age.Abnormal gonadal fat pad:* males fed on a high-fat diet from 4 weeks of age show significant increases in weight of gonadal white fat depositsAbnormal hypothalamus physiology:* 14-week old female mutants show a 51% increase in Pomc expression vs controls in the arcuate nucleus consistent with reduced food intake, while males show a 21% decrease in Npy expression and a 25% increase in Pomc, associated with increased lean mass and serum hormone levels; Ghrh is increased 32% in the ventromedial hypothalamic nucleus of mutants.Behavior/neurological phenotype:* mutants show no alterations in motor activity over a 14 day observation period",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[788,"Y2f","B6.129-Npy2r<tm1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Normal","NPY-Y2 receptor","MGI:108418","targeted mutation 1, Herbert Herzog","Npy2r<tm1Hhz>","MGI:2447395","3",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[1638,"Chloe","C57BL/6-Acan<tm1Afos>",null,"Recessive","aggrecan","Acan","Normal","Agc1, Cspg1","MGI:99602","aggrecan; targeted mutation 1, Amanda J Fosang","Acan<tm1Afos>","MGI:3577026","7",{"$nulls":15},"Yes",{"$nulls":12},"Mutants develop normally with no skeletal abnormalities but do not accumulate aggregan in cartilage even though Agc1 is not cleaved by matrix metalloproteases",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-17"]
[7529,"Sost","C57BL/NTac-Sost<tm1(KOMP)Vlcg/Ausb","C57BL/NTac-Sost<tm1(KOMP)Vlcg/Ausb","Recessive","sclerostin","Sost",null,null,"MGI:1921749","sclerostin; targeted mutation 1, Velocigene","Sost<tm1(KOMP)Vlcg>","MGI:3797839","11",{"$nulls":28},"Skeleton phenotype:\t• mice exhibit normal osteoclast activity.Increased compact bone area.Abnormal osteoblast morphology:• 3-fold increase in bone formation at the distal femur.• increased bone formation at the endocortical surface of the femur midshaft.Abnormal trabecular bone morphology:• lower trabecular separation, increased osteoblast surface and reduced structure model index at 6 months.Increased trabecular bone volume:• at 6 monthsIncreased bone trabecula number:• at 6 monthsIncreased trabecular bone connectivity density:• at 6 monthsIncreased bone mass:• 3-foldAbnormal bone ossification:• 2-fold increase in bone formation at the distal femur.Abnormal bone mineralization:• increased mineral apposition rateAbnormal compact bone morphology:• tibial cortical bone area, bone thickness, and polar moment of inertia are increased compared to in wild-type mice.Increased bone mass:• in the tibiaAbnormal osteoblast physiology:• osteocyte apoptosis is reduced compared to in wild-type mice",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-12-04"]
[3586,"C57BL/6.NOD/Lt-KRN","B6.NOD-Tg(TcraR28,TcrbR28)KRNDim",null,"Dominant",{"$nulls":25},"transgene insertion KRN, Diane Mathis","natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak. These mice develop spontaneous rheumatoid arthritis (RA) joint disease highly reminiscent of man. The trigger for the murine disorder is chance recognition of a NOD-derived major histocompatibility complex (MHC) class II molecule by the transgenic TCR.",null,"C57BL/6 x NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-05"]
[792,"NPY KO x PYY KO","B6.129-Npy<tm1(cre)Tkar> Pyy<tm1(cre)Hhzg>",null,"Semi-dominant","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"Yes",{"$nulls":12},"Locomotor and exploratory behaviour was decreased in male and female PYY+NPY-/- mice during the photo- and scotophase.Significant decreases in water and food intake were seen in male and female PYY+NPY-/- mice during the photophase.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[792,"NPY KO x PYY KO","B6.129-Npy<tm1(cre)Tkar> Pyy<tm1(cre)Hhzg>",null,"Semi-dominant","peptide YY","Pyy","Nil",null,"MGI:99924","targeted mutation 1, H Herzog","Pyy<tm1(cre)Hhzg>","MGI:3664105","Unknown"]
[6678,"ELTON","B6.129S5-Tpsb2<tm1(cre)Adch>/Ausb",null,"Recessive","tryptase beta 2","Tpsb2","Nil","Mcp-6, Mcp6, Mcpt6, MMCP-6 ","MGI:96942","tryptase beta 2; targeted mutation 1, Roberto Adachi","Tpsb2<tm1(cre)Adch>","MGI:3722523","17",{"$nulls":28},"Increased susceptibility to bacterial infection:*A substantially reduced ability to combat K. pneumoniae infections of their peritoneal cavities.*Produced normal-sized litters, showed no obvious developmental abnormality, and had a normal lifespan when maintained in a pathogen-free animal facility.*The peritoneal mast cells showed no substantial alteration in their size or shape or in the numbers, size and density of their secretory granules.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[218,"Pitx2-lacZ","Pitx2-lacZ",null,"Dominant","paired-like homeodomain transcription factor 2","Pitx2","Unknown","Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin","MGI:109340",{"$nulls":3},"3",{"$nulls":15},"Yes","LacZ","Pitx2",{"$nulls":10},"Viable and fertile",null,"C57BL/6 x FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[808,"Y2 KO x NPY KO","B6.129-Npy<tm1(cre)Tkar> Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Nil","NPY-Y2 receptor","MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":15},"Yes",{"$nulls":14},"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[808,"Y2 KO x NPY KO","B6.129-Npy<tm1(cre)Tkar> Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6"]
[811,"Y1Y5f","B6.129-Npy1r<tm1Wpg> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[811,"Y1Y5f","B6.129-Npy1r<tm1Wpg> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y5","Npy5r","Unknown","Y5R","MGI:108082",{"$nulls":3},"8"]
[6346,"Vavbcl69","C57BL/6-Tg(Vav-BCL2)1Jad",null,"Semi-dominant",{"$nulls":25},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","Overexpression",{"$nulls":9},"Abnormal lymphocyte cell number:*The ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.      Increased B cell number:      *5-fold higher in the spleen at 18 weeks.      Increased T cell number:      *Mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.         Increased CD4-positive T cell number:         *The increase in CD4+ T cells is greater than the increase in CD8+ T cells.         Increased CD8-positive T cell number:         *The increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:*The total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:*22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleenAbnormal spleen germinal center morphology:*Mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.*At 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.*However, expansion of germinal centers is dependent on CD4 T cell help.      Increased spleen germinal center number:      *At 18 weeks.      Increased spleen germinal center size:      *At 18 weeks.Enlarged lymph nodesGlomerulonephritis:*At 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:*12% of mice develop plasma cell tumors.      Increased lymphoma incidence:      *Less than 10% of mice develop lymphoblastic lymphomas.         B cell derived lymphoma:         *Less than 10% of mice develop large cell B lymphomas.            Follicular lymphoma:            *At 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.         Increased histiocytic sarcoma incidence:         *In less than 10% of mice.         Thymic lymphoma:         *In less than 10% of mice.Abnormal renal glomerular capsule:*Bowman epithelium proliferates to form crescents in the most advanced cases.Abnormal renal glomerulus morphology:*Mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits.*Most capillaries are no longer patent.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7046,"FST Flox","B6.129-Fst<tm2Zuk>/MarpApb",null,"Dominant","follistatin","Fst",null,null,"MGI:95586","follistatin; targeted mutation 2, Martin M Matzuk","Fst<tm2Zuk>","MGI:3040645","13",{"$nulls":28},"Normal","Normal","C57BL/6J x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-08-13","Cryopreserved sperm"]
[3425,"Crlf1 KO","B6.129-Crlf1<tm1Wsa>/Wehi",null,"Recessive","cytokine receptor-like factor 1","Crlf1","Nil","CLF-1, CRLM3, cytokine receptor like molecule 3, NR6.1","MGI:1340030","targeted mutation 1, Warren S Alexander","Crlf1<tm1Wsa>","MGI:2387956","8",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.Neonatal lethality: at birth, homozygotes are present at the expected Mendelian frequency; however, no homozygotes survive beyond 24 hrs after birth.Absent gastric milk in neonates: newborn homozygotes contain no milk in their stomachs.Abnormal suckling behavior: newborn homozygotes open and close their mouths but fail to suckle effectively, despite the absence of gross or histologic abnormalities in brain (i.e. cortex and hippocampus), olfactory bulb, as well as facial or mouth tissues.Decreased motor neuron number:* newborn homozygotes display a significantly reduced number of motoneurons in the lumbar spinal cord, with no apparent change in the brachial or thoracic cord.* newborn homozygotes also exhibit a significant decrease in the number of motoneurons in the facial but not hypoglossal nucleus; sensory neurons of the dorsal root ganglia remain unaffected.Impaired hematopoiesis:* newborn homozygotes display reduced numbers of hemopoietic progenitor cells in the bone marrow and spleen* no differences in the numbers and lineage commitment of progenitor cells are observed in neonatal liver.",null,"129/Sv x C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2008-07-15"]
[5614,"B16A  (Nod Cg Tg)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7259,"HSA-Cre-ER T2","B6.129S2-Tg(ACTA1-cre/ERT2)97.16Mtz/NrosMarpApb","B6.129S2-Tg(ACTA1-cre/ERT2)97.16Mtz/Nros","Semi-dominant",{"$nulls":25},"transgene insertion 97.16, Daniel Metzger","human skeletal alpha-actin (ACTA1)",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[5289,"B6.TBM.Tg.1142-7.PAR1.KO","C57BL/6-F2r<tm1Ajc> Tg(H2-K<b>-TBM)",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No","human thrombomodulin","H2-K<b>","vascular endothelium and neutrophils",{"$nulls":9},"Unknown",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[3562,null,"C57BL/6-Mnt<tm>",null,"Recessive","max binding protein","Mnt","Nil","Rox","MGI:109150",{"$nulls":3},"11",{"$nulls":15},"No",{"$nulls":12},"Postnatal lethality * homozygotes die within a few days of birthtumorigenesisAltered tumor susceptibility* MEFs infected with c-Myc and H-Ras viruses develop higher numbers of transformed foci* transformed cells capable of anchorage independent growthCellularAbnormal cell physiology * at early passages show improved growth rates and higher cell densities* enter more quickly into S phase* higher apoptosis levels in culture 24 hours after serum withdrawl* faster development of immortalized cell linesGrowth/SizeDecreased embryo size * apparent by E13.5",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01"]
[4935,"Cathepsin-S Knockout","C3H-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C3H","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-24"]
[7432,"Y20A","B6.129-Atp4b<tm1Ird> Tg(Atp4b*Y20A)/Ird/Apb",null,"Dominant","ATPase, H+/K+ exchanging, beta polypeptide","Atp4b","Nil","H+,K+-ATPase, H+/K+-ATPase beta, H,K-ATPase-Beta","MGI:88114","ATPase, H+/K+ exchanging, beta polypeptide; targeted mutation 1, Ian R van Driel","Atp4b<tm1Ird>","MGI:2158258","8",{"$nulls":16},"Mutated form of H+/K+ ATPase β subunit","CMV","moderate to high",{"$nulls":9},"Gastric Parietal cells of these mice lacked a tubulovesicular compartment, and the H/K ATPase was resident exclusively on the apical plasma membrane. Despite the inability of the H/K ATPase to be endocytosed, the gastric acid secretory response to histamine or an antagonist was very similar to that of wild-type mice,","normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">10",null,null,"No","2013-09-10","Cryopreserved sperm"]
[36,"Dopey ; ENU3strain:031","B6;NOD-Ddr2<m1Anu>/AnuApb","B6;NOD-Ddr2<m1Anu>/AnuApb","Recessive","discoidin domain receptor family, member 2","Ddr2",null,"Ntrkr3","MGI:1345277","mutation 1, The Australian National University","Ddr2<m1Anu>","MGI:5008734","1","ENSMUSG00000026674","ENSMUST00000170800","Ddr2-202",{"$nulls":7},"171932145","6",null,null,"TCTCTTCTCTCCTCTTCCCATGGCCTGAGCAGCATGACTGAAGGGCTAGGCCAGTTGACT","Yes",{"$nulls":12},"Dwarf, short face",null,"C57BL/6JSfdAnu x NOD/Lt.Cg-H2<k>","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm"]
[1947,"C57BL/6-TLR-4<tm1> ; Teague","B6;129P2-Tlr4<tm1Aki>/AnuApb","B6;129P2-Tlr4<tm1Aki>","Recessive","toll-like receptor 4","Tlr4","Nil","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; targeted mutation 1, Shizuo Akira","Tlr4<tm1Aki>","MGI:1860885","4",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-01","Cryopreserved sperm"]
[5586,"3G",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4704,"NODβ2M-/- β2Mb homozygous 8.3TCRαβ","NOD.B6-B2m<tm1Jae> Tg(B2mb)1Rms Tg(TcraTcrbNY8.3)1Pesa/MarpApb",null,"Recessive","beta-2 microglobulin","B2m","Unknown","beta 2 microglobulin, beta2-m, Ly-m11","MGI:88127","targeted mutation 1, Rudolf Jaenisch","B2m<tm1Jae>","MGI:1927183","2",{"$nulls":15},"Yes","transgene insertion 1, Robyn M Slattery",{"$nulls":13},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 1, Robyn M Slattery"]
[8566,"ASD949:PKR big del:EIF2AK2","C57BL/6NCrlAnu-Eif2ak2<em2Anu>/AnuApb",null,"Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Unknown","2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-21","Cryopreserved sperm"]
[1761,"Caspase-9 knockout","C57BL/6-Casp<tm1Flv>/Wehi",null,"Recessive","caspase 9","Casp9","Nil","Caspase-9, ICE-LAP6, Mch6","MGI:1277950","targeted mutation 1, Richard A Flavell","Casp9<tm1Flv>","MGI:2158755","4",{"$nulls":15},"No",{"$nulls":12},"Perinatal lethality: normal mendelian ratio at E16.5 but fewer than 3% of the pups born are homozygotes.Abnormal neural tube closure: failure of neural tube closure in hindbrain region apparent by E10.5 and persists.Abnormal brain morphology.Abnormal brain development: enlargement of the proliferative zone in the forebrain and midbrain with resultant protrusion of brain mass.Abnormal embryonic neuroepithelial layer differentiation:* lacking pyknotic clusters* lamina terminalis of the forebrain is thicker with increased number and density of cells.Abnormal forebrain development.Abnormal telencephalon development: E16.5 expanded midbrain displaces telencephalic vesicles.Exencephaly: by E16.5 prominent exencephaly of the entire cranial tissues with enlarged and irregularly shaped protruding brain masses.Abnormal brain ventricle morphology: stenosis of the cerebral ventricles, lateral and third ventricles obstructed by E13.5.Abnormal lateral ventricle morphology.Abnormal third ventricle morphology.Abnormal telencephalon morphology: heterotopias and discontinuities of the proliferative ventricular zone lead to invagination and complete interruption of the telencephalic wall.Abnormal cerebral cortex morphology.Abnormal midbrain morphology.Decreased neuron apoptosis:* E13 olfactory epithelium has lower levels of olfactory receptor neuron apoptosis than normal.* absence of activated caspase 3 in the developing brain as assessed by immunohistochemistry with antibody CM1.* nearly 10 fold reduction in TUNEL-positive cells in E12.5 neuroepithelium.* fewer TUNEL-positive cells in the E16.5 spinal cord and E12.5 dorsal root ganglia although there is no change in TUNEL staining in E12.5 liver.Normal apoptosis in interdigital webbing retraction.Abnormal thymocyte apoptosis: thymocytes are delayed in apoptotic response to anti-CD3 + andi-CD28, etoposide, gamma irradiation, and dexamethasone, but have normal apoptotic response to Fas stimulation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10",null,null,"No","2007-08-02"]
[4179,"APN7","B6;29-Ifrd1<Gt(AZ0065)Wtsi>/MIMR",null,"Recessive","interferon-related developmental regulator 1","Ifrd1","Unknown","Ifnl, PC4, Tis7","MGI:1316717","interferon-related developmental regulator 1; gene trap AZ0065, Wellcome Trust Sanger Institute","Ifrd1<Gt(AZ0065)Wtsi>","MGI:3857584","12",{"$nulls":15},"Yes",{"$nulls":12},"Unknown.  Note: Homozygous null mice display impaired muscle regeneration and myogenic differentiation and decreased body weight in older mice.","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1",null,"Chimera x C57BL/6","No","2008-12-18","Cryopreserved sperm"]
[841,"OT2; OTII","C57BL/6-Tg(TcraTcrb)425Cbn",null,"Dominant",{"$nulls":25},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.T cells express T cell receptor specific for chicken ovalalbumin residues 323 - 339 in the context of H2-Ab1 (I-A<b>)Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous transgenic mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[7047,"βA Flox","B6.129S7-Inhba<tm3Zuk>/MarpApb",null,"Dominant","inhibin beta-A","Inhba",null,"activin","MGI:96570","inhibin beta-A; targeted mutation 3, Martin M Matzuk","Inhba<tm3Zuk>","MGI:3758877","13",{"$nulls":28},"Normal","Normal","C57BL/6 x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-08-13","Cryopreserved sperm"]
[4602,null,"MRL/MpJ-Fas<lpr>/MarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"Premature death, decreased B cell number, decreased CD4 and CD8 -positive T cell number, decreased activated T cell number, increased double-negative T cell number, enlarged spleen and lymph nodes, abnormal leukocyte rolling - increased adhesion, development of anti-nuclear antibodies, glomerulonephritis. ",null,"MRL/MpJ","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[7260,"MLC-IGF/F08 (MLC=mIGF-1-8) ","B6(Cg)-Tg(Myl1-Igf1)1Nros/MarpApb","B6(Cg)-Tg(Myl1-Igf1)1Nros","Semi-dominant",{"$nulls":25},"transgene insertion 1, Naida Rosenthal","myosin light chain",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[1738,"VavP-BCL2-45","C57BL/6-Tg(Vav-BCL2)45Jad/Wehi",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","transgene insertion 45, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":10},"Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[847,"Traf2 floxed","C57BL/6-Traf2<tm1Rbr>",null,"Dominant","Tnf receptor-associated factor 2","Traf2","Normal",null,"MGI:101835","targeted mutation 1, Robert Brink","Traf2<tm1Rbr>","MGI:3511494","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[4951,"Ifne<f/f>","C57BL/6-Ifne<tm1Phe>",null,"Recessive","interferon epsilon","Ifne",null,"Ifne1, Ifnt1","MGI:2667156",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-12-10"]
[75,"Theodor","ENU4AT:011",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Low IgG2a response to B. pertussis",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2004-08-18","Cryopreserved sperm"]
[4601,null,"NOD.B6-Socs3<tm2Wsa>/WehiApb",null,"Dominant","suppressor of cytokine signaling 3","Socs3","Normal","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":15},"Yes",{"$nulls":12},"Normal. When crossed with Cre expressing strain allows deletion of Socs3 in tissue specific manner.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","7",null,"Socs3<tm2Wsa> x NOD","No","2009-03-13","Cryopreserved sperm"]
[843,"SW{HEL}-H","C57BL/6-Igh<tm1Rbr>",null,"Dominant",{"$nulls":25},"immunoglobulin heavy chain complex; targeted mutation 1, Robert Brink",{"$nulls":11},"B cells express immunoglobulin Heavy chain that recognises hen egg lysozyme.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[4598,null,"B6.129-Apc<Min> Myb<tm1Ssp>",null,"Semi-dominant","adenomatosis polyposis coli","Apc","Nil","Min","MGI:88039","multiple intestinal neoplasia","Apc<Min>","MGI:1856318","18",{"$nulls":15},"Yes",{"$nulls":12},"For Myb<tm1Ssp> Homozygous null fetuses are severely anemic due to defects in fetal hepatic hematopoiesis.  Embryonic lethal at E15.5For Apc<min> Homozygotes are embryonic lethal.","For Apc<min> heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding.For Myb<tm1Ssp> are viable and fecund","C57BL/6 x 129","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Apc<min+/-> Myb<tm1Ssp +/-> x Apc<min+/-> Myb<tm1Ssp +/->","No","2009-03-13"]
[4598,null,"B6.129-Apc<Min> Myb<tm1Ssp>",null,"Semi-dominant","myeloblastosis oncogene","Myb","Unknown","c-myb","MGI:97249","targeted mutation 1, S Steven Potter","Myb<tm1Ssp>","MGI:2662859","10"]
[6426,"Blys2tg","B6.Cg-Tg(Tnfsf13b)1Fma/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Fabienne Mackay","human liver-specific alpha-1-antitrypsin promoter",{"$nulls":10},"Increased B cell number:*Splenic B cell numbers are about twice that of controls.      Increased transitional stage B cell number:        *Numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled.      Increased marginal zone B cell number:        *The number of splenic marginal zone B cells is increased by about 3-fold.Abnormal B cell activation:*B cells have a vigorous response to T cell independent antigens producing much higher levels of IgG1, IgG2a, IgG2b, IgG3, and IgA class immunoglobulins than controls.Abnormal spleen marginal zone morphology:*The size of the marginal zone is increasedAbnormal marginal zone B cell physiology:*Marginal zone B cells (MZB) mediate autoimmune disease in these transgenic mice as demonstrated by auto-antibody production when MZB are transferred into transgenic mice on a B-cell deficient background.*MZB from transgenic mice have higher integrin adhesion activity.Increased anti-double stranded DNA antibody level:*Anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation.*Titers of these auto-antibodies increase with.*Splenectomy at three weeks of age significantly reduces IgG auto-antibodies and partially reduces auto-antibodies in the other subclasses.Glomerulonephritis:*Kidneys of 10-month old mice have necrotic lesions.*Immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG.Proteinuria:*All 8-month old mice have proteinuria in their urine with most having 100-300 mg/dl.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[848,"Traf3 KO","C57BL/6-Traf3<tm1.1Rbr>",null,"Recessive","Tnf receptor-associated factor 3","Traf3","Unknown","CAP-1, CD40bp, CRAF1, LAP1","MGI:108041","targeted mutation 1.1, Robert Brink","Traf3<tm1.1Rbr>","MGI:3777325","12",{"$nulls":15},"Yes",{"$nulls":12},"Not analysed",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[173,null,"C57BL/6-Tau-GFP",null,"Dominant",{"$nulls":26},"CMV intermediate early enhancer coupled to the chicken beta actin promoter",{"$nulls":10},"Every cell expresses a tau-GFP fusion protein, enabling visualization of microtubules and long cell processes (including axons). Mice homozygous for the transgene do not survive.  ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[1712,"Rag2 gammaC","C57BL/6-IL2rg<tm1Cgn> Rag2<tm1Fwa>",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg","Nil","[g]c, CD132, common cytokine receptor gamma chain, common gamma chain, gamma C receptor, gamma(c), gc","MGI:96551","interleukin 2 receptor, gamma chain; targeted mutation 1, University of Cologne","Il2rg<tm1Cgn>","MGI:1861947","X",{"$nulls":15},"Yes",{"$nulls":12},"Severely immunocompromised throughout life.The common gamma (gc) KO mouse lacks functional receptors for many cytokines including IL-2, IL-4, IL-7, IL-9, and IL-15. As a consequence lymphocyte development is greatly compromised. The mouse lacks Natural Killer (NK) cells and produces only a small number of T and B cells. To eliminate the residual T and B cells this mouse was crossed to the recombinase activating gene 2 (Rag-2) deficient mouse. The double knock-out should now lack T cells, B cells, and NK cells. A preliminary analysis of this strain showed no detectable NK1.1+ cells, B220+ B cells or Thy1+ T cells in the spleen. A small number of the 1-3 million cells obtained were CD45 low and probably are cells in the macrophage/monocyte lineage. Functional tests, performed by Drs. Elias Hadaad and Pierre Henkart of NIH, for NK killing activity in the spleen, with or without poly I:C stimulation, were negative.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-26"]
[1712,"Rag2 gammaC","C57BL/6-IL2rg<tm1Cgn> Rag2<tm1Fwa>",null,"Recessive","recombination activating gene 2","Rag2","Unknown","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2"]
[185,null,"OMP-tau:GFP",null,"Recessive","olfactory marker protein","Omp","Nil",null,"MGI:97436","targeted mutation 3, Peter Mombaerts","Omp<tm3Mom>","MGI:3692201","7",{"$nulls":15},"Yes",{"$nulls":12},"All primary olfactory neurons express GFP",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[186,"P2-IRES-tauLacZ","B6.129-Olfr17<tm1Mom>",null,"Dominant","olfactory receptor 17","Olfr17","Unknown","GA_x6K02T2PBJ9-9470146-9471093, MOR263-5, P2","MGI:109148","targeted mutation 1, Peter Mombaerts","Olfr17<tm1Mom>","MGI:2179510","7",{"$nulls":15},"No",{"$nulls":12},"P2 odorant receptor neurons express LacZ",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[187,null,"VR1-IRES-tau:GFP",null,"Dominant",{"$nulls":37},"A subpopulation of vomeronasal neruons innervating the rostral accessory olfactory bulb express GFP",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[1787,"Bax / Bak knockout","129-Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice lacking bax display limited phenotypic abnormalities. Bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-) bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.      Those that survive are runted and grey.",null,"129/Sv","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1787,"Bax / Bak knockout","129-Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","Bcl2-associated X protein","Bax","Unknown",null,"MGI:99702","targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7"]
[645,null,"IL-12 KO",null,"Dominant","not sure if alpha or beta",null,"Unknown",{"$nulls":5},"1",{"$nulls":15},"Yes",{"$nulls":15},"No","No","No","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25"]
[7345,"PTEN lox P locus/MMTV CRE","B6.129P2-Pten<tm2Mak> Tg(MMTV-Cre)4Mam/Apb",null,"Dominant","phosphatase and tensin homolog","Pten",null,null,"MGI:109583","phosphatase and tensin homolog; targeted mutation 2, Tak W Mak","Pten<tm2Mak>","MGI:2182005","19",{"$nulls":16},"transgene insertion 4, Lothar Hennighausen","mouse mammary tumor virus (MMTV) long terminal repeat",{"$nulls":10},"Neoplastic proliferation of prostate and skin tissues","Susceptible to tumour development","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-05-28","Cryopreserved sperm"]
[7666,"Depdc5-w","B6;C-Depdc5<m1Wehi>/AnuApb","B6.Cg;C-Depdc5<m1Wehi>/AnuApb","Recessive","DEP domain containing 5","Depdc5","Unknown",null,"MGI:2141101","DEP domain containing 5; mutation 1, Walter and Eliza Hall Institute","Depdc5<m1Wehi>","MGI:5648439","5","ENSMUSG00000021431","ENSMUST00000091641","Snrnp48-201","794","828","A to G","ENSMUSE00000117800","7","265","Aspartic acid to Glycine",{"$nulls":4},"CTGGCAGGAAGAGCAGGGGAGAGCAGGAGACGCTGCTGAGAAGAATGAAGAAAGGCGGTCA",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",null,"G3","Het x Het","No","2014-04-28","Cryopreserved sperm"]
[175,"OVE550","FVB/N-Tg(Cryaa-Tgfbr2*)550/Apb",null,"Dominant",{"$nulls":25},"truncated TGFβ receptor II, kinase deficient","αA-crystallin, Cryaa",{"$nulls":10},"Nuclear cataract, characterised by rapid apoptosis and death of terminally differentiating lens fibres cells at E18.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17","Cryopreserved sperm"]
[202,"TGFbRIII floxed","Tgfbr3<flox>",null,"Recessive","transforming growth factor, beta receptor III","Tgfbr3","Normal","betaglycan, TBRIII","MGI:104637",{"$nulls":3},"5",{"$nulls":15},"Yes",{"$nulls":12},"Phenotypically normal. When crossed to Cre transgenics, will create knockout of TGFbRIII gene",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-20"]
[7084,"MommeD33","FVB/NJ-MommeD33 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D33","Su-var39h","Unknown",null,null,"modifier of murine metastable epialleles, D33",null,null,"X",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"homo viable","Normal","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"MommeD33<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-14","Cryopreserved sperm"]
[5214,"mIMPα4FL (low level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)low",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","low level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-08-30","Cryopreserved sperm"]
[647,"AMY","Un-Tg(APPswe,PSEN1dE9)85Dbo",null,"Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","mouse prion promoter",{"$nulls":11},"Amyloidosis.Amyloid beta deposits.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25"]
[4099,null,"KRN:187",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Hypo response post arthritogenic serum transfer",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"1",null,"No","2008-12-04","Cryopreserved sperm"]
[1812,"C57BL/6. Socs2 KO","C57BL/6-Socs2<tm1Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 2","Socs2","Nil","CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2","MGI:1201787","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs2<tm1Wehi>","MGI:1934557","10",{"$nulls":15},"Yes",{"$nulls":12},"SOCS-2(-/-) mice grew significantly larger than their wild-type littermates. Increased body weight became evident after weaning and was associated with significantly increased long bone lengths and the proportionate enlargement of most organs. Characteristics of deregulated growth hormone and insulin-like growth factor-I (IGF-I) signalling, including decreased production of major urinary protein, increased local IGF-I production, and collagen accumulation in the dermis, were observed in SOCS-2-deficient mice, indicating that SOCS-2 may have an essential negative regulatory role in the growth hormone/IGF-I pathway. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[5552,"Dravid","C57BL/6-Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":16},"transgene insertion 1100, Michael J Bevan",null,"High - 49 Copies",{"$nulls":9},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-10","Cryopreserved sperm"]
[4079,null,"ENU6PH:058",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"6",null,"No","2008-12-04","Cryopreserved sperm"]
[7344,"PBCre","B6;DBA2-Tg(Pbsn-cre)4Prb/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 4, Pradip Roy-Burman","rat Pbsn",{"$nulls":11}," Cre recombinase is expressed postnatally in prostatic epithelium with the highest level of expression in the lateral lobe of the prostate gland. A very low level of transgene expression was detected in the seminal vesicles, testes, and ovaries.","(C57BL/6 x DBA/2)F1","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-05-28","Cryopreserved sperm"]
[706,null,"NOD.Cg-Igh-6<tm1Cgn> Tg(IghelMD4)4Ccg/Dvs",null,"Recessive","immunoglobulin heavy chain 6 (heavy chain of IgM)","Igh-6","Nil","BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","targeted mutation 1, University of Cologne","Igh-6<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"Yes",{"$nulls":12},"Do not express endogenous IgM, viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.All B lymphocytes in NOD.Igh-6 deficient transgenic mice express Ig molecules specific for HEL.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-02"]
[8570,"K 14 cre ERT 2  B6 tg","B6-Tg(K14-cre/ERT2)/Vccc",null,"Dominant",{"$nulls":25},"K14-cre","K14",{"$nulls":13},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[1785,"Cathepsin D knockout","Un-Ctsd<tm1Cptr>",null,"Recessive","cathepsin D","Ctsd","Nil","CatD, CD","MGI:88562","targeted mutation 1, Cristoph Peters","Ctsd<tm1Cptr>","MGI:2182078","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null mutation die in a state of anorexia at ~P26, displaying severe atrophy of the intestinal mucosa, and massive destruction of the thymus and spleen with loss of T and B cells; near the terminal stage, affected mice have seizures, display retinal atrophy, and become blind.",null,null,"Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1816,"Oct2 deltaC","B6.129-Pou2f2<tm1Lmc>/Wehi",null,"Recessive","POU domain, class 2, transcription factor 2","Pou2f2","Normal","Oct-2, Oct2a, Oct2b, Otf-2, Otf2","MGI:101897","POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran","Pou2f2<tm1Lmc>","MGI:3037094","7",{"$nulls":15},"No",{"$nulls":12},"Neonatal lethality: homozygous mice die shortly after birth.Decreased B cell number: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced.Decreased B-1 B cell number: these mice also lack peritoneal B-1 cells.Arrested B cell differentiation: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling.Decreased immunoglobulin level: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[5593,"A2Kb ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5594,"Actm0va (actin0va)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[703,"NR4MD4","NOD.NOR-(D4Mit31-D4Mit310) Tg(IghelMD4)4Ccg",null,"Dominant","insulin dependent diabetes susceptibility 9","Idd9","Unknown","Idd-9","MGI:96411","NOR/LtJ","Idd9<NOR/LtJ>","MGI:3582457","4",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-02"]
[1730,"B6 Bclw -/- 228","B6.129-Bcl2l2<tm1Sco>/Wehi",null,"Recessive","Bcl2-like 2","Bcl2l2","Nil","Bcl-w, bclw, Gtrgal2, Gtrosa41","MGI:108052","targeted mutation 1, Suzanne Cory","Bcl2l2<tm1Sco>","MGI:2158430","14",{"$nulls":15},"Yes",{"$nulls":12},"Most tissues exhibited typical histology, and hematopoiesis was unaffected, presumably due to redundant function with other pro-survival family members. Although female reproductive function was normal, the males were infertile. The testes developed normally, and the initial, prepubertal wave of spermatogenesis was largely unaffected. The seminiferous tubules of adult males, however, were disorganized, contained numerous apoptotic cells, and produced no mature sperm. Both Sertoli cells and germ cells of all types were reduced in number, the most mature germ cells being the most severely depleted.",null,null,"Yes","Yes","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-01"]
[774,"NIDM5MD4ML5","NOD-Idd5<C57BL/10> Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg",null,"Dominant","insulin dependent diabetes susceptibility 5","Idd5<C57BL/10>","Nil","Idd-5","MGI:2389023","C57BL/10","Idd5<C57BL/10>","MGI:2389023","1",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":12},"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-18"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow",null,"High"]
[7609,"Pax7","B6.D2-Tg(Pax7-EGFP)#Tajb/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion, Shahragim Tajbakhsh","Pax7","muscle",{"$nulls":9},"Expression of nGFP in muscle satellite cells.","Expression of nGFP in muscle satellite cells.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-02-28"]
[1824,null,"B6.129-H2-Ab1<tm1Gru>",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Nil","A beta, Abeta, H-2Ab, H2-Ab, I-Ab, I-Abeta, Ia-2, Ia2, IAb, Rmcs1","MGI:103070","targeted mutation 1, Michael J Grusby","H2-Ab1<tm1Gru>","MGI:2158420","17",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.Decreased CD4-positive T cell number.Increased CD8-positive T cell number.Abnormal level of surface class II molecules: MHC II complex is not expressed on the surface of cells.Decreased IgG1 level.Decreased IgM level.Abnormal response to transplant:* skin grafts from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen) are indistinguishable from wild-type donor skin grafts for the first 40 days.* rejection starts occurring after 40 days with 25% of the transgenic grafts being completely lost after 115 days.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"The colony is maintained by brother x sister mating of homozygotes.","No","2007-08-06"]
[781,"VAMP2 KO","C57BL/6-Vamp2<->",null,"Recessive","vesicle-associated membrane protein 2","Vamp2","Nil","Syb-2, Syb2, synaptobrevin II","MGI:1313277",{"$nulls":3},"11",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2007-05-19"]
[776,null,"B6.Cg-Tg(Fabp4-cre)1Rev/J",null,"Dominant",{"$nulls":25},"transgene insertion 1, Ronald M Evans","fatty acid binding protein 4, adipocyte, mouse (Fabp4)",{"$nulls":10},"Transgene expressed in brown and white adipose tissue.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-18"]
[5247,"ENU11B6 45a","ENU11B6:045a",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to infection with TB",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good","0","5","Sib x sib","No","2010-10-19","Cryopreserved sperm"]
[8571,"Pb-1 cre fvb/n","FVB/N-Tg(Pb1-cre)VcccApb",null,"Dominant",{"$nulls":25},"Pb1-cre",{"$nulls":13},"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[8574,"MMTV-Neu/FVB/N","FVB-Tg(MMTVneu)/WehiVccc",null,"Dominant",{"$nulls":25},"transgene insertion 202, William Muller","MMTV (mouse mammary tumor virus)",{"$nulls":10},"These mice develop tumours at approximately 6 - 8 months.   Mammary adenocarcinoma.Metastatic potential.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[6766,"Ert2/Stat3flox/gp130F ","STOCK Stat3<tm2Aki> Tg(Gpa33-cre/ERT2)/LudApb",null,"Recessive","signal transducer and activator of transcription 3","Stat3","Normal","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 2, Shizuo Akira","Stat3<tm2Aki>","MGI:1926816","11",{"$nulls":16},"cre recombinase","glycoprotein A33 (transmembrane)",{"$nulls":10},"Gastric polyps, maybe developing later and fewer than gp130 ff mice, and maybe additional phenotypes in other tissues.","Unknwon","Mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-16","Cryopreserved sperm"]
[7085,"floxed CYP27B1 ","B6.129-Cyp27b1<tm1.1Star>/Apb",null,"Dominant","cytochrome P450, family 27, subfamily b, polypeptide 1","Cyp27b1","Normal","1alpha(OH)ase, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25(OH)D 1alpha-hydroxylase, Cp2b, Cyp1, Cyp27b, Cyp40, P450c1, P450VD1alpha, Pddr, Vdd1, Vddr, VddrI","MGI:1098274","cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1.1, Rene St-Arnaud","Cyp27b1<tm1.1Star>","MGI:2656261","10",{"$nulls":28},"Normal","Normal","C57BL6/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">4",null,null,"No","2012-09-18","Cryopreserved sperm"]
[4086,null,"ENU8PH:025 , Cletus",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Alopecia (Hair loss).",null,"C57BL/6 x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[4932,"Aire knockout 384","BALB/c-Aire<tm1Scot>/Wehi",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Unknown",null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. An increase in the number of activated T cells was evident, and autoantibodies against several organs were detected. At the histological level, lymphocytic infiltration of several organs indicated the development of autoimmunity, although symptoms were mild.Male infertility.",null,"BALB/c","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-11-19"]
[786,"PY1 KO","B6.129-Npy1r<tm1.1Wpg>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Nil","Npyr, Y1-R","MGI:104963","targeted mutation 1.1, William P Gray","Npy1r<tm1.1Wpg>","MGI:3053796","8",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.Increased litter size:* average litter size is 7.64 +/- 0.51 compared to 4.86 +/- 0.32 in wild-type mice.Decreased B cell number: all B cell subsets reducedDecreased transitional stage B cell number: type 1 and type 2 cells both reduced.Decreased mature B cell number.Abnormal T cell number.Decreased CD8-positive T cell number: slightly reduced in the spleen.Increased single-positive T cell number:Increased CD4-positive T cell number: significantly increased in the lymph nodes.Increased CD8-positive T cell number: significantly increased in the lymph nodes.Abnormal immune system organ morphology.Abnormal spleen morphology.Decreased marginal zone B cell number.Abnormal splenic cell ratio: reduced B cell numbers among splenocytes.Small spleen.Abnormal lymph node cell ratio: reduced numbers of B cells.Abnormal immune system physiology.Abnormal immune cell physiology.Abnormal T cell activation: hyper responsive to activation.Abnormal antigen presenting cell physiology: antigen presentation defective as tested by mixed lymphocyte response tests.Abnormal immunoglobulin level.Decreased IgG2a level: both baseline levels and levels in response to antigen are reduced.Increased immunoglobulin level: in response to antigenIncreased IgA level.Increased IgG2b level.Increased IgM level.Abnormal macrophage physiology: levels of Il12 released are reduced.* levels of TNF released are reduced.Abnormal T-helper 1 physiology: impaired* protected against Th1 cell mediated inflammatory conditions such as those resulting from sodium dextran sulfate treatmentAbnormal inflammatory response.Decreased circulating interleukin-12 level: decreased levels released by macrophage.Decreased circulating tumor necrosis factor level: decreased levels released by macrophage.Decreased interferon-gamma secretion: reduced productionDecreased susceptibility to type IV hypersensitivity reaction:* swelling reduced to 55% that of controls* reduced proliferation of lymph node cells* reduced production of IFN-gammaIncreased aggression towards mice:* territorial aggression but not spontaneous aggression is increased in homozygous mutants* injection of an Htr1a agonist reduces aggressive behavior in a dose-dependent mannerHyperactivity: homozygous males display increased movement in an open field test.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[787,"Y2 KO","B6.129-Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Nil",null,"MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[8572,"Brca2","FVB/N-Brca2<tm1>/VcccApb",null,"Recessive","Brca2",{"$nulls":7},"Unknown",{"$nulls":30},"FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[1825,"PUT/Mxcre","C57BL/6-Sfpi1<tm1.2Nutt> Tg(Mx1-cre)1Cgn",null,"Recessive","SFFV proviral integration 1","Sfpi1","Unknown","Dis-1, PU.1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1","MGI:98282","targeted mutation 1.2, Stephen L Nutt","Sfpi1<tm1.2Nutt>","MGI:3578011","2",{"$nulls":15},"Yes","transgene insertion 1, University of Cologne","Inducible MX1",{"$nulls":10},"Prior to PolyIC treatment the phenotype is the same as wild type phenotype of the same genetic background. After polyIC treatment (ie after the deletion of PU.1 gene) mice exhibit transient weight loss, which sometimes can be sever (more than 10%) and splenomegaly. Myeloid leukaemia development in average 6 months after polyIC treatment.Absent erythrocytes: bone marrow lacked the nucleated erythroid cells that represent 17% of the control bone marrow.Decreased B cell number: B lymphocyte numbers were reduced variably in the bone marrow, with most cells having a preB cell phenotype.Increased granulocyte number: expansion of granulocyte precursors in the bone marrow and spleen.Abnormal granulocyte differentiation: granulocytes maintained c-kit expression and displayed some, but not complete, maturation.Extramedullary hematopoiesis: spleen cells generated vastly increased numbers of granulocytic colonies, excessive numbers of megakaryocytic colonies and IL-3 responsive macrophage-containing colonies.Abnormal bone marrow cell morphology/development: the bone marrow contained normal total cellularity but exhibited an increased proportion of blast cells, and immature cells of the granulocyte lineage (promyelocytes and myelocytes).Absent common myeloid progenitor cells:* bone marrow lacked eosinophil colony-forming cells that were responsive to granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 or IL-5, but had greatly elevated numbers of granulocytic colonies developed when stimulated by G-CSF, IL-3 or stem cell factor but not with IL-6.* few or no megakaryoctye colonies developed in cultures of bone marrow cells under optimal culture for megakaryoctye formation.* loss of any readily identifiable lymphoid and myeloid progenitor or stem cell populations.Abnormal spleen morphology: in severe cases, spleen showed homogeneous infiltration by immature granulocytic forms and loss of splenic architecture.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[3416,"RIP-OVA<hi>","C57BL/6-Tg(Ins2-OVA)59Wehi/Wehi",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 59, Walter and Eliza Hall Institute of Medical ResearchTg(Ins2-OVA)59Wehi","rat insulin 2","High - 49 Copies",{"$nulls":9},"Mice bearing this transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14"]
[3426,"anti-Hy transgenic strain","C57BL/6-Tg(TcraH-Y,TcrbH-Y)71Vbo",null,"Dominant",{"$nulls":25},"transgene insertion 71, Harald von Boehmer",{"$nulls":11},"Cells expressing the H-Y antigen were frequent in female but not male transgenic offspring, despite the fact that peripheral T cells in animals of both sexes expressed both transgenes, T cells in male (but not female) mice had an abnormal CD4/CD8 phenotpye: over 90% of T cells in male transgenic mice were CD4-8- or expressed only low levels of CD8 molecules and the numbers of CD4+8- T cells were very small.  This was due to deletion of autospecific thymocytes expressing high levels of CD8 molecules predominantly CD4+8+.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15"]
[790,"Y4f","B6.129-Ppyr1<tm1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Normal","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1, Herbert Herzog","Ppyr<1tm1Hhz>","MGI:2183928","14",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-19"]
[791,"Y1f","B6.129-Npy1r<tm1Wpg>",null,"Dominant","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[807,"NPY KO x DYN KO","B6.129-Npy<tm1(cre)Tkar> Pdyn<tm1(cre)Czer>",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"Yes","Cre recombinase",{"$nulls":11},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[807,"NPY KO x DYN KO","B6.129-Npy<tm1(cre)Tkar> Pdyn<tm1(cre)Czer>",null,"Recessive","prodynorphin","Pdyn","Nil","Dyn","MGI:97535","targeted mutation 1, Christoph Schwarzer","Pdyn<tm1(cre)Czer>","MGI:3715202","2"]
[7121,"Id3Fva∆","FVB/N(Cg)-Id3<tm1Cmu>/AusbApb",null,"Recessive","inhibitor of DNA binding 3","Id3","Nil","bHLHb25, HLH462, Idb3","MGI:96398","inhibitor of DNA binding 3; targeted mutation 1, Cornelis Murre","Id3<tm1Cmu>","MGI:3046425","4",{"$nulls":28},"Id3 nulls do not breed.Although ID3 deficiency (Id3(-/-) mice) had no noticeable impact on epididymal histology, the targeted mutation adversely affected sperm motility parameters. Moreover, principal component analysis of microarray data indicated that the gene expression signatures for tissues obtained from Id3(-/-) mice and their genotypic controls were distinct from each other in each epididymal region. The predominant effect of the Id3 null mutation was in the cauda region where the expression of many transcription factors, including Hoxb8 and Bclaf1, was markedly affected.Abnormal T cell differentiation: * the total number of thymocytes is unchanged however the percent and total number of CD4 single positive cells is significantly decreased and the percent and total number of CD8 single positive cells is slightly decreased * after 5 generations of backcrossing onto a C57BL/6J background slightly increased compared to wild-typeAbnormal double-positive T cell morphology: a small but consistent increase in CD5 expression is seen compared to wild-type littermates","None","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","6",null,"Heterozygous pairs","No","2012-10-31","Cryopreserved sperm"]
[3467,"Asb1 KO","C57BL/6-Asb1<tm1Wehi>/Wehi",null,"Recessive","ankyrin repeat and SOCS box-containing 1","Asb1","Nil","1700029O08Rik, 1700054C17Rik, mKIAA1146","MGI:1929735","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Asb1<tm1Wehi>","MGI:2178847","1",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutation of this gene results in spleen hypocellularity, decreased spermatogenesis, and thickening of the epithelial layer of the skin in male animals.Abnormal testis morphology:* in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes.* however, this abnormal testicular morphology has no impact on male fertility.Abnormal spermatogenesis: mutant testes frequently show less complete filling of the seminiferous tubules, suggesting reduced spermatogenesis.Hematopoietic system phenotype:* homozygotes show normal hemopoiesis, both at steady state and in response to several forms of hematopoietic stress* also, mutants exhibit no abnormalities of mature blood cells or their progenitors.Small spleen: homozygotes show normal splenic architecture but a mild reduction in spleen size.Spleen hypoplasia: reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset.Thickened epidermis:*56% of male homozygotes display thickening of the epithelial layer of skin, either in discrete patches or in a generalized distribution; only 14% of control C57BL/6 male mice exhibit epithelial thickening.* epithelial thickening is associated with squamous differentiation and some keratin formation; however, mutants show no consistent infiltration of cells in the underlying dermis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[8573,"UBC-Cre/ERT2 Tg x FVB/N ; iCre","FVB/N.Cg-Tg(UBC-cre/ERT2)1Ejb/VcccApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Eric J Brown","human ubiquitin C (UBC) promoter",{"$nulls":11},"Mice display tamoxifen-inducible Cre activity in all tissue types. ","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[1750,"Lck-Cre","B6.129-Tg(Lck-cre)157Jxm/WehiAnuApb",null,"Dominant",{"$nulls":25},"targeted mutation I57, Jamey Marth; transgene insertion I57, Jamey Marth","mouse proximal Lck promoter","active in thymocytes and splenocytes",{"$nulls":9},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10","sib x sib","No","2007-08-02","Cryopreserved sperm"]
[812,"Y1Y5 KO","B6.129-Npy1r<tm1> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Unknown",null,"MGI:104963",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[812,"Y1Y5 KO","B6.129-Npy1r<tm1> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y5","Npy5r","Unknown","Y5R","MGI:108082",{"$nulls":3},"8"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Nil","Npyr, Y1-R","MGI:104963","targeted mutation 1.1, William P Gray","Npy1r<tm1.1Wpg>","MGI:3053796","8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Unknown","NPY-Y2 receptor","MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Nil","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14"]
[1751,"SOCS<lox>","B6.129-Socs1<tm3Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Normal","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","suppressor of cytokine signaling 1; targeted mutation 3, Walter and Eliza Hall Institute of Medical Research","Socs1<tm3Wehi>","MGI:2656917","16",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[4952,"APN 15","B6.129-Slc2a3<Gt(XG611)Byg>/MIMR",null,"Recessive","solute carrier family 2 (facilitated glucose transporter), member 3","Slc2a3","Reduced","Glut-3, Glut3","MGI:95757","solute carrier family 2 (facilitated glucose transporter), member 3; gene trap XG611, BayGenomics","Slc2a3<Gt(XG611)Byg>","MGI:3822325","6",{"$nulls":29},"Nervous system phenotype:* no paroxysmal EEG activity* no epileptic seizuresAbnormal brain wave pattern: absolute EEG power densities show a slight but significant elevation.Decreased prepulse inhibition:* significant reduction in inhibition by a low intensity prepulse* inhibition due to a high intensity prepulse is normalBehavior/neurological phenotype:* performance normal in rotarod, open field, and shuttle box tests.* normal performance in a Morris water maze.* generally normal responses in anxiety related tests although some trends are noted.Increased anxiety-related response:* preference for closed compartment in elevated maze.* increased tendency to stay in illuminated areas in light/dark avoidance tests.Increased startle reflex: increased startle response.","C57BL/6 x 129","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2009-12-14","Cryopreserved sperm"]
[4438,"APN14","B6.129-Kdm1a<Gt(XP0207)Wtsi>/MIMR",null,"Recessive","lysine (K)-specific demethylase 1A","Kdm1a","Unknown","Aof2, Kdm1, LSD1, mKIAA0601","MGI:1196256","lysine (K)-specific demethylase 1A; gene trap XP0207, Wellcome Trust Sanger Institute","Kdm1a<Gt(XP0207)Wtsi>","MGI:3858605","4",{"$nulls":15},"No",{"$nulls":12},"Unknown for genetrap. Germline deletion of Aof2 causes early embryonic lethality (E7.5) probably due to defects in pituitary development and hormone production.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","1",null,null,"No","2009-02-17","Cryopreserved sperm"]
[7206,"classII-mOVA","C57BL/6-Tg(H2-Ab1-TFRC/OVA)3Cbn/Apb","C57BL/6-Tg(H2-Ab1-TFRC/OVA)3Cbn","Dominant",{"$nulls":25},"ovalbumin residues 139-385 fused to transferrin receptor membrane domain","MHC class II","moderate",{"$nulls":9},"NormalClass II mOVA mice express a membrane-bound form of ovalbumin (transferrin receptor membrane domain and OVA residues 139-385) under the control of the MHC class II promoter. OVA expression is directed to the membranes of cells that express MHC class II, such as B cells, macrophages and dendritic cells.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-11-09","Cryopreserved sperm"]
[3477,"CBA.Rip-H2-Kb (lineage 50-1)","CBA-Tg(Ins2-H2-K<b>)/Wehi",null,"Dominant",{"$nulls":25},"H-2Kb heavy chain","rat insulin 2","In beta cells",{"$nulls":9},"Spontaneous, non-immune diabetes by 4-6 weeks of age. Diabetes is generally more severe in males (mean=23.0, sd=4.0 mmol/l at 6 weeks) compared to females (mean=16.8, sd=2.2 at 6weeks). Also appears to be more severe in homozygous compared to heterozygous mice although no formal analysis of the latter has been performed. Diabetes is stable and sufficiently mild that most heterozygous mice can be maintained to 40 weeks of age without parenteral insulin.","Diabetes is stable and sufficiently mild that most heterozygous mice can be maintained to 40 weeks of age without parenteral insulin.","CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",null,null,"Maintained as heterozygous line (CBA +/+ female x 50-1/CBA T/+ male)","No","2008-07-22"]
[2744,"SXR","B6.CBA-Tg(Sox3)1Pqt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Paul Q Thomas","Sox3 promoter","2 copies; High with aberrant expression in gonads and CNS",{"$nulls":9},"Transgenic line only maintained as hemizygous. ","High Sox3 expression with aberrant expression in gonads and CNS. Heterozygous females will develop phenotypically as males in approximately 80% of cases. These animals also have occasional dwarfism as well as a tendency to develop hydrocephalus due to CNS abnormalities. Sex-reversed XX tg/+ males are sterile","CBA x C57BL/6","No","No","Yes","No","No","Yes","No","Good",null,null,"Tg/+ Male mated to a wildtype female","No","2008-02-10","Cryopreserved sperm"]
[3553,null,"C57BL/6.129-Mpl<tm1Wsa>",null,"Recessive","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, thrombopoietin receptor, TPO-R","MGI:97076","targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.  Decreased hematopoietic stem cell number - in clonal culture of bone marrow, total progenotor cell number was 38%- 44% of wildtype.  Neutrophil-CFC, neutrophil-macrophage-CFC and pure erythroid-CFC were present at approximately 50% of normal levels.  Abnormal megakaryocyte progenitor cell morphology -mice are deficient in megakaryocyte progenitor cellsDecreased platelet cell number - mice had only 6% the number platelets detected in controlsAbsent megakaryocytes - mutant mice displayed a loss of megakaryocytes in the spleen and bone marrow",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31"]
[4110,null,"KRN:153",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm"]
[3595,null,"C57BL/6.129-Rag1<tm1Mom> Ly5.1",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.   Mice homozygous for the Rag1tm1Mom mutation produce no mature T cells or B cells. Their phenotype can be described as a \"non-leaky\" severe combined immune deficiency (Prkdcscid/Prkdcscid) (Prkdcscid mice produce some B cells and IgM). They have no CD3+ or T cell receptor (TCR) alpha-beta positive cells. The thymus of the mutant mice contains 15 to 130 times fewer cells than heterozygous or wildtype siblings. The thymocytes are CD8-CD4- and most are IL2 receptor positive. Neither the spleen nor bone marrow contain any IgM or IgD staining cells, indicating an absence of mature B cells. These and other data suggest that B cell and T cell development has been arrested at an early stage. Macroscopically, the mutants are indistinguishable from heterozygotes or normal wildtype siblings. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06"]
[7230,"KRasG12D","B6.129-Kras<tm4Tyj>/JMarpApb",null,"Dominant","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","Kras","Normal","Ki-ras, K-ras, Kras2, Kras-2","MGI:96680","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks","Kras<tm4Tyj>","MGI:2429948","6",{"$nulls":28},"Normal until mice crossed with Cre expressing strain.Expression of adenovirus controlled Cre recombinase results in lung tun our development.Treatment with adenoviral Cre injection results in ovarian endometriosis like lesions.Abnormal peritoneum morphology: * 47% of mutants develop peritoneal endometriosis following ovarian intrabursal injection of an adenovirus expressing Cre * however, mice injected with adenovirus expressing Cre directly into the peritoneum do not develop peritoneal endometriosis.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-22","Cryopreserved sperm"]
[7358,"ENU25 26 TNPO3","C57BL/6NCrlAnu-Tnpo3<m1Anu>/AnuApb","C57BL/6NCrlAnu-Tnpo3<m1Anu>/AnuApb","Recessive","transportin 3","TNPO3","Unknown","5730544L10Rik, C430013M08Rik, D6Ertd313e ","MGI:1196412","transport in 3; mutation 1, The Australian National University","Tnpo3<m1Anu>","MGI:5563403","6","ENSMUSG00000012535","ENSMUST00000012679","Tnpo3-001","1508","1910","A to T","ENSMUSE00001238723","12","503","Leucine to STOP",{"$nulls":4},"CCGGAATCCCCAGTTCCTGGACCCTGTATTGGGCTATTTGATGAAAGGCCTGTGTGAAAAG",{"$nulls":13},"Homozygous mutation appears lethal","Heterozygous mice appear healthy and normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Good",null,"Generation 4","HET x HET","No","2013-06-20","Cryopreserved sperm"]
[7237,"K5rTA-TSLP 0419","C57BL/6-Tg(K5-rTA)04Cbn Tg(TetO-TSLP)19Cbn/Apb",null,"Dominant",{"$nulls":25},"tetracycline-regulated transcriptional transactivator","bovine keratin-5",{"$nulls":10},"In these mice following oral doxycyline treatment, rTA expresssion induced in the skin activates the TetO promoter driving TSLP expression in the skin.In the absence of doxycyline treatment the mice are normal for lifespan and breeding.","As for homozygous mice.","C57Bl/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Tg/+ +/+ x +/+ Tg/+","No","2012-11-28","Cryopreserved sperm"]
[{"$nulls":30},"tetracycline-regulated transcriptional transactivator","bovine keratin-5"]
[3522,"NOD.B6-Idd14","NOD.B6-Idd14<C57BL/6>",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 14","Idd14","MGI:99416","13",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[1755,"Bmf Del/376","C57BL/6-Bmf<tm1.1Anvi>/Wehi",null,"Recessive","Bcl2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1.1, Andreas Villunger","Bmf<tm1.1Anvi>","MGI:3778610","2",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal spleen morphology.Enlarged spleen: significantly enlarged at 12 months.Spleen hyperplasia: increased by more than 50%.Abnormal immune system cell morphology.Abnormal B cell morphology: increased immature B cell number.Increased pre-B cell number: significantly elevated numbers in bone marrow while pro-B cell numbers are normal.Increased transitional stage B cell number:* both T1 and T2 transitional B cells are elevated* increased T1 transitional B cells in inguinal lymph nodesIncreased mature B cell number: * mature B cell numbers are elevated.* increased numbers in inguinal lymph nodes* increased numbers in peripheral bloodIncreased follicular B cell number: elevated while marginal B cell numbers are normal.Decreased B cell apoptosis: highly resistant to apoptosis caused by dexamethasone.Increased immunoglobulin level: total serum levels elevated at 8-10 weeks but not at 1 year of age.Decreased T cell apoptosis:* double positive T cells with increased resistance to the apoptotic effects of dexamethasone* thymocytes and double positive T cells resistant to the apoptotic effects of suberoylanilide hydroxamic acidTumorigenesis: no B cell neoplasia through 18 months of ageThymic lymphoma: increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[1361,"IL21 KO","B6.129-IL21<tm1Lex>",null,"Recessive","interleukin 21","Il21","Nil",null,"MGI:1890474","targeted mutation 1, Lexicon Genetics","Il21<tm1Lex>","MGI:3528994","3",{"$nulls":15},"No",{"$nulls":12},"Decreased germinal center B cell number:* the percentage of GC B cells that make up the total B cell population in the spleen of immunized mice is reduced by two-thirdsAbnormal CD4-positive T cell morphology:* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Abnormal spleen germinal center morphology:* the number of actively proliferating T cells found within GC is reduced 3- to 4- fold.* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Decreased spleen germinal center number:* there is a paucity of GC in the spleen of mice after immunization with sheep red blood cells (SRBC).Decreased CD4-positive T cell number:* Il-17+ CD4+ cells are absent from lamina propria and spleen in mutants.Abnormal T cell differentiation:* when naive TH cells are subjected to TH17 differentiation, a deficit in generation of Il-17-producing cells is observed with an increased number of Foxp3+ cells compared to wild-type.* one week after immunization with MOG peptide in CFA, restimulation of spleen cells with TPA or MOG peptide results in production of almost no Il-17 producing cells, showing impaired TH17 differentiation.Abnormal gamma-delta T cell morphology:*lamina propria and splenic TCRgd+ T cells show <10-fold decrease in Il-17-expressing cells compared to wild-type cells.Abnormal interleukin level:* CNS-infiltrating and splenic CD4+ T cells produce interferon gamma, in contrast to CD4+ T cells from controls which produce predominantly Il-17.",null,"129/SvEvBrd x C57BL6/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22"]
[5442,"81.BR ; (ADAR2—/—/AGluR-B<R/R>)","B6;129-Adarb1<tm1Phs> Gria2<tm1.1Phs>",null,"Recessive","adenosine deaminase, RNA-specific, B1","Adarb1","Reduced","ADAR2, D10Bwg0447e, RED1","MGI:891999","adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg","Adarb1<tm1Phs>","MGI:2178079","10",{"$nulls":15},"No",{"$nulls":12},"No abnormal phenotype detected: double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)","Adarb1<tm1Phs>/Adarb1<tm1Phs>Gria2<tm1.1Phs>/Gria2<+>Postnatal lethality: compound mutant mice survive up to P35 (partial rescue; extended postnatal survival).","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","Unknown",null,null,"No","2011-02-17","Cryopreserved sperm"]
[5442,"81.BR ; (ADAR2—/—/AGluR-B<R/R>)","B6;129-Adarb1<tm1Phs> Gria2<tm1.1Phs>",null,"Recessive","glutamate receptor, ionotropic, AMPA2 (alpha 2)","Gria2",null,"Glur-2, GluR-B, GluR2, Glur2","MGI:95809","glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1.1, Peter H Seeburg","Gria2<tm1.1Phs>","MGI:2178125","3",{"$nulls":15},"Yes"]
[4516,null,"ENU8C:011",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[7262,"LysM-Cre Rb","B6(Cg)-Lyz2<tm1(cre)Ifo> Rb1<tm3Tyj>/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Normal","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":28},"No obvious phenotype. No effect on lifespan, breeding or skeleton","None observed. LysM-Cre mice are ok as both heterozygous and homozygous alleles","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5","unknown/not collected","LysM-Creki/+ pRBfl/+ male to LysM-Creki/+ pRBfl/+ female","No","2013-01-18","Cryopreserved sperm"]
[7262,"LysM-Cre Rb","B6(Cg)-Lyz2<tm1(cre)Ifo> Rb1<tm3Tyj>/StvApb",null,"Dominant","lysozyme 2","Lyz2 ","Nil","Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp ","MGI:96897","lysozyme 2; targeted mutation 1, Irmgard Forster ","Lyz2tm1(cre)Ifo","MGI:1934631","10"]
[7668,"ASCIZ CD23 Bcl6","B6.Cg-Atmin<tm1.2Jhh> Ighm<tm1(Bcl6)Rdf> Tg(Fcer2a-cre)5Mbu/SviApb",null,"Dominant","ATM interactor","Atmin",null,null,"MGI:2682328","ATM interactor; targeted mutation 1.2, Jorg Heierhorst","Atmin<tm1.2Jhh>","MGI:5463937","8",{"$nulls":16},"transgene insertion 5, Meinrad Busslinger","Fcer2a  ",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","more than 10",null,null,"No","2014-04-30","Cryopreserved sperm"]
[7668,"ASCIZ CD23 Bcl6","B6.Cg-Atmin<tm1.2Jhh> Ighm<tm1(Bcl6)Rdf> Tg(Fcer2a-cre)5Mbu/SviApb",null,"Dominant","immunoglobulin heavy constant mu","Ighm",null,"BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT","MGI:96448","immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera","Ighm<tm1(Bcl6)Rdf>","MGI:3581517","12"]
[1777,"B6.Bim Knockout clone 339 del","C57BL/6-Bcl2l11<tm1.1Ast>/Wehi",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Reduced","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"No",{"$nulls":12},"Increased numbers of lymphoid and myeloid cells. Spleen and lymph modes are 2-3-fold bigger than in wt. Sternum is sticking out.  Bim-/- females are bad mothers and should not be used for breeding unless necessary.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[6743,"KIf3LoxP","Klf3-LoxP conditional/Ausb",null,"Recessive",null,"Klf3",{"$nulls":6},"Unknown",{"$nulls":28},"None",null,"BL6/129SV/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[7244,"CMV-cre","C57BL/6-Tg(CMV-cre)1Cgn/WehiArcApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, University of Cologne","human cytomegalovirus (CMV) promoter",{"$nulls":11},"Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-12-11","Embryo"]
[5297,"CD39 KO","C57BL/6-Entpd1<tm1Rdr>",null,"Recessive","ectonucleoside triphosphate diphosphohydrolase 1","Entpd1","Nil","Cd39, ectoapyrase, NTPDase-1","MGI:102805","ectonucleoside triphosphate diphosphohydrolase 1; targeted mutation 1, Robert D Rosenberg","Entpd1<tm1Rdr>","MGI:2182811","19",{"$nulls":15},"No",{"$nulls":12},"Cardiac fibrosis.Abnormal blood flow velocity: terminal erythrocyte velocity is increased (17.1+/-5.2 compared to 3.3+/-3.3 mm per second in wild-type mice).Abnormal vascular endothelial cell physiology: ATPase and ADPase activities are substantially decreased compared to in wild-type mice.Decreased platelet cell number: platelet count is 20% lower than in wild-type mice (538+/-78x103 per mm3 compared to 740+/-81x103 per mm3 in wild-type mice).Decreased platelet aggregation: * in vitro, platelets fail to aggregate in response to ADP, collagen or low doses of thrombin. * however, treatment with a soluble potato ATPase restores aggregation response.Increased bleeding time: * bleed time is increased to greater than 20 minutes in 4 mice and greater than 7 minutes in 7 mice compared to 1.0+/-0.2 minutes in heterozygous mice. * treatment with ferric chloride revealed a delay in platelet plug formation with no thrombi formation after 20 minutes compared to 100% in wild-type mice.Abnormal neutrophil physiology: * polymorphonuclear (PMN) cells fail to convert etheno-AP into etheno-AMP as do wild-type PMNs. * following activation, the supernatant surrounding PMNs accumulate 1.6+/-0.09-fold more ATP than from wild-type PMNs. * unactivated PMN supernatant accumulates more ATP than wild-type.Fibrosis: mice exhibit increased fibrin deposits in the lungs, heart and spleen and in some mice the liver, kidney and brainPulmonary fibrosis: fibrin deposits are present in the lungs and worsen after thrombogenic challenge.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm"]
[5367,"NODTNFR1","NOD.Cg-Tnfrs1a<tm1Blt>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Unknown","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-alpha-R1, TNF-alphaR1, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Horst Bluethmann","Tnfrsf1a<tm1Blt>","MGI:1861040","6",{"$nulls":15},"No",{"$nulls":12},"Absent follicular dendritic cells: organized follicular dendritic cell networks are absent.Abnormal Peyer's patch morphology: the typical subepithelial dome areas fail to form.Abnormal Peyer's patch follicle morphology: B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent.Decreased Peyer's patch number: * average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice * however, T cell populations in the thymus and T and B cell populations in the spleen and lymph nodes are normal.Abnormal lymph node B cell domain: B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however B cells are present and B and T cell areas are segregated.Abnormal immune system physiology.Increased susceptibility to type I hypersensitivity reaction: significant reduction in bronchoalveolar lavage leukocytosis in an ovalbumin-induced allergic asthma model.Decreased interleukin-6 secretion: LPS-induced IL-6 secretion is reduced about 3-fold compared to wild-type mice; however TNF secretion is similar to wild-type.Increased susceptibility to bacterial infection: * infection with as few as 250 colony forming units of Listeria monocytogenes results in 100% mortality by 6 days after infection, all wild-type mice survive this treatment. * D-galactosamine sensitized homozygotes can survive 100-fold higher concentrations of LPS than wild-type; however without D-galactosamine sensitization both types of mice show similar sensitivity to LPS-induced mortality. * however, homozygotes are able to control infections of lymphocytic choriomeningitis virus.Increased susceptibility to parasitic infection: * T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice * however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[7246,"MLC-hAP","C57BL/6-Tg(Myl1-AP)1Nros/MarpApb",null,"Semi-dominant",{"$nulls":25},"human alkaline phosphatase","myosin light chain (MLC)",{"$nulls":10},"Unknown","Normal.Expression of human alkaline phosphatase in skeletal muscle.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-12-12","Cryopreserved sperm"]
[1640,"Bailey","C57BL/6-Col2a1<tm1>",null,"Recessive","procollagen, type II, alpha 1","Col2a1","Normal","Col2a, Col2a-1, Del1","MGI:88452",{"$nulls":3},"15",{"$nulls":15},"Yes",{"$nulls":12},"Mice have shortened and deformed limbs.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-17"]
[5947,"NfixKO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4478,null,"129-Nos2<tm1Mrl>/AnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Unknown","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, John S Mudgett","Nos2<tm1Mrl>","MGI:2158791","11",{"$nulls":15},"No",{"$nulls":14},"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-02-22","Cryopreserved sperm"]
[7254,"FTL-BALB/C","BALB/c-Tg(fos-tau/LacZ)/Apb",null,"Dominant",{"$nulls":25},"FOS-TAU-LACZ","C-FOS","Distribution and expression similar to engogenous c-fos",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent",">30",null,"FTL+ FEMALE X FTL+ MALE","No","2013-01-09","Cryopreserved sperm"]
[5298,"CD39.Tg","C57BL/6-Tg(H2-K<b>-ENTPD1)",null,"Dominant",{"$nulls":25},"human ectonucleoside triphosphate diphosphohydrolase-1","H2-K<b>",{"$nulls":11},"Human CD39 (hCD39) is widely expressed in transgenic mice.hCD39 prolongs bleeding times and protects against induced thrombosis.AMP and adenosine levels are increased in hCD39 transgenic mice.hCD39 protects transgenic mouse cardiac grafts from Ab-mediated rejection.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm"]
[350,"p75<NTR>","129-Ngfr<tm1Jae>",null,"Recessive","nerve growth factor receptor (TNFR superfamily, member 16)","Ngfr","Unknown","LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16","MGI:97323","targeted mutation 1, Rudolf Jaenisch","Ngfr<tm1Jae>","MGI:1857226","11",{"$nulls":15},"No",{"$nulls":12},"Viable and fertile.Homozygotes for targeted mutations exhibit increased perinatal lethality, skin abnormalities, growth retardation, reduced sensory nerve innervation, elevated pain threshold, ataxia, reduced sciatic nerve diameter, and blood vessel abnormalities.Decreased sensory innervation by calcitonin gene-related peptide- and substance P-immunoreactive fibers.The defective innervation was correlated with loss of heat sensitivity and associated with the development of ulcers in the distal extremities. Complicated by secondary bacterial infection, the ulcers progressed to toenail and hair loss. ",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-09-29"]
[7261,"APN246","C57BL/6N(Ag)-Casp9<tm1a(EUCOMM)Hmgu>MarpApb",null,"Recessive","caspase 9","Casp9 ",null,"Caspase-9, ICE-LAP6, Mch6 ","MGI:1277950 ","\tcaspase 9; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH ","Casp9tm1a(EUCOMM)Hmgu","MGI:4950193","4",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-17","Cryopreserved sperm"]
[1706,"Gin","C57BL/6-Tg(Col2a1-cre)1Asz",null,"Dominant",{"$nulls":25},"transgene insertion 1, Attila Aszodi","Cartilage specific Col2a1 gene promoter",{"$nulls":10},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-25"]
[5615,"B2ca",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5616,"B2M",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2745,"NSXR","B6.CBA-Tg(Sox3-EGFP)NrPqt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion Nr, Paul Q Thomas","Sox3 promoter","High level of expression at restricted regions in CNS",{"$nulls":9},"N/A as transgenic line is maintained at hemizygous state state","High level of expression at restricted regions in CNS. Hydrocephalus with at least 10% penetrance.","CBA x C57BL/6","No","No","Yes","No","No","Yes","No","Poor",null,null,"Tg/+ male to wt female","No","2008-02-10","Cryopreserved sperm"]
[3558,null,"C57BL/6-Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn Ptprc<b>/Wehi",null,"Recessive",{"$nulls":25},"transgene insertion L118-1, Francis R Carbone ","a 2 kb fragment of the H-2Kb and a 700 bp fragment including the Igh enhancer.",{"$nulls":10},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01"]
[5299,"B6.TBM.Tg","C57BL/6-Tg(H2-K<b>-THBD)",null,"Dominant",{"$nulls":25},"human thrombomodulin","H2-K<b>","Strong on peripheral blood lymphocytes",{"$nulls":10},"hTBM transgenic mice were indistinguishable from WT littermates in appearance, size, level of activity and fertility.Transgenically expressed hTBM protects against pulmonary arterial thromboembolism.Transgenically expressed hTBM protects against venous thrombosis.Transgenically expressed hTBM reduces the inflammatory infiltrate after IVC ligation.Transgenically expressed hTBM reduces HMGB1 levels.Transgenically expressed hTBM prolongs cardiac graft survival and reduces infiltrating T cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm"]
[3582,null,"Rb(12.T17<16>65Dn)2Cje",null,"Dominant",null,null,"Increased","Ts(Rb(12.17<16>))2Cje",null,"Robertsonian translocation, Chr 12 and T1716Dn, Charles J Epstein 2","Rb(12.T17<16>65Dn)2Cje","MGI:3531161","Unknown",{"$nulls":15},"Yes",{"$nulls":12},"This strain has three copies of most of the genes on mouse Chromosome16 that are homologues of human Chromosome 21 genes. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04"]
[8575,"LGN-VenusC","B6.Cg-Gpsm2<tm1.1(Venus)Fuma>/FumaVcccApb",null,"Dominant","G-protein signalling modulator 2 (AGS3-like, C. elegans)","Gpsm2",null,"6230410J09Rik, LGN, Pins","MGI:1923373","G-protein signalling modulator 2 (AGS3-like, C. elegans); targeted mutation 1.1, Fumio Matsuzaki","Gpsm2<tm1.1(Venus)Fuma>","MGI:3850859","3",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27"]
[6738,"Klf3-8-bY-FV","FVBn-tm<Klf3>.Klf8GT. tg(bYAC)/Ausb",null,"Recessive",null,"Klf3,Klf8,bYAC",{"$nulls":35},"Embryonic lethalDouble homozygous is 100% embryonic lethal. Klf3KO homozygote is 50% embryonic lethal. KlfKO/Klf8 het is 90% embryonic lethal. Klf8KO has no obvious pheontype. bYAC expresses human globin genes- no affect on mouse.",null,"FVBn","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[7362,"Grhl3 flox","B6.129S1-Grhl3<tm3.1Jane>/MarpApb",null,"Recessive","grainyhead-like 3 (Drosophila)","Grhl3","Normal",null,"MGI:2655333","grainyhead-like 3 (Drosophila); targeted mutation 3.1, Stephen M Jane","Grhl3<tm3.1Jane>","MGI:5306651","4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"fl/fl x fl/fl","No","2013-06-26","Cryopreserved sperm"]
[7136,"LRRK1","C57BL/6N-Lrrk1<tm1.1Youy>/JAusb","C57BL/6N-Lrrk1<tm1.1Youy>/JAusb","Recessive",null,"LRRK1",null,null,"MGI:4940302",{"$nulls":34},"C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7082,"Momme D31","FVB/NJ-Trim28<MommeD31> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","tripartite motif-containing 28 ","Trim28","Unknown","KAP-1, KRIP-1, Tif1b","MGI:109274","tripartite motif-containing 28; modifier of murine metastable epialleles, D31","Trim28<MommeD31>",null,"7",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Death at E6-E8","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD31<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-13","Cryopreserved sperm"]
[3538,null,"C57BL/6-Prdm1<tm1Nutt> /  Pou2af1<tm1Pmt>",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Blimp T/T mice die late in gestation, regardless of OBF-1 genotype  ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29"]
[3538,null,"C57BL/6-Prdm1<tm1Nutt> /  Pou2af1<tm1Pmt>",null,"Recessive","POU domain, class 2, associating factor 1","Pou2af1","Unknown","Bob-1, BOB.1, Bob1, OBF-1, OBF.1, OCA-B, OCAB","MGI:105086","targeted mutation 1, Patrick Matthias","Pou2af1<tm1Pmt>","MGI:2388055","9"]
[5008,"Hbdd5.1","C57BL/6-Ptprc<a> Hbb<d>",null,"Dominant",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","C57BL/6 mice express the a allele of Ptprc and the d allele of hemoglobin beta chain. Both alleles are homozygous.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5008,"Hbdd5.1","C57BL/6-Ptprc<a> Hbb<d>",null,"Dominant",{"$nulls":28},"hemoglobin beta chain complex","Hbb",null,null,"MGI:96020","hemoglobin beta chain complex; d","Hbb<d>","MGI:1858119","7","C57BL/6 mice express the a allele of Ptprc and the d allele of hemoglobin beta chain. Both alleles are homozygous.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[7257,"MLC:2IGF-1B_3D (Class 2Eb) ; SP2-IGF-1Eb","B6.FVB-Tg(Myl1-SP2/IGF1Eb)1Nros/MarpApb","B6.FVB-Tg(Myl1-SP2/IGF1Eb)1Nros","Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain","skeletal muscle",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[7363,"RhoGEF19 flox","B6.129S1-Arhgef19<tm1Jane>/Marp",null,"Recessive","Rho guanine nucleotide exchange factor (GEF) 19","Arhgef19","Normal","6430573B13Rik, WGEF","MGI:1925912","Rho guanine nucleotide exchange factor (GEF) 19, targeted mutation 1 Stephen Jane","Arhgef19<tm1Jane>",null,"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"fl/fl x fl/fl","No","2013-06-27","Cryopreserved sperm"]
[4812,"ENU8BAT:070:Wash","C57BL/6JSfdAnu-Henmt1<m1Anu>/AnuApb",null,"Recessive","HEN1 methyltransferase homolog 1 (Arabidopsis)","Henmt1","Unknown","4921515J06Rik, Hen1","MGI:1913965",{"$nulls":3},"3","ENSMUSG00000045662","ENSMUST00000106586","4921515J06Rik-204",{"$nulls":7},"108745775","3",null,null,"ATTTAGTGGATCGCCATGAACCCAAGAAGGTAATTATTATTATTATTATTGTTATTATTA","Yes",{"$nulls":12},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[7258,"MLC-Cre","B6.FVB-Tg(Myl1-cre)13Nros/MarpApb","B6.FVB-Tg(Myl1-cre)13Nros","Semi-dominant",{"$nulls":25},"Tg(Myl1-cre)13Nros","myosin light chain (MLC)",{"$nulls":10},"Unknown","Normal.Expression of cre recombinase in skeletal muscle.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[7310,"K5rTA-Rae1-32","C57BL/6-Tg(K5-rTA)04Cbn Tg(TetO-RaeT1e)32Cbn/Apb",null,"Dominant",{"$nulls":25},"tetracycline-regulated transcriptional transactivator","bovine keratin-5",{"$nulls":10},"In these mice following oral doxycyline treatment, rTA expresssion induced in the skin activates the TetO promoter driving RaeT1e expression in the skin.Following doxycycline treatment, RaeT1e expression is weak in these mice.","As for homozygous mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"4","Tg Tg x Tg Tg","No","2013-04-09","Cryopreserved sperm"]
[{"$nulls":30},"tetracycline-regulated transcriptional transactivator","bovine keratin-5"]
[3589,"Balb/c-Blimp KO","BALB/c-Prdm1<tm1Nutt>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Prenatal lethality - homozygotes die late in gestation.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-05"]
[3625,null,"C57BL/6.129S4-Cxcl10<tm1Adl>",null,"Recessive","chemokine (C-X-C motif) ligand 10","Cxcl10","Nil","C7, CRG-2, gIP-10, Ifi10, INP10, IP-10, IP10, mob-1, Scyb10","MGI:1352450","targeted mutation 1, Andrew D Luster","Cxcl10<tm1Adl>","MGI:2180678","5",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal cytokine secretion * only CCL2 levels are elevated in corneas relative to wild-type or Cxcl9-null mice after HSV-1 infectionIncreased susceptibility to experimental autoimmune encephalomyelitis * higher incidence and greater severity of experimental autoimmune encephalomyelitisCNS inflammation * experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days* monocytes lymphocytes and some granulocytes are involved* increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodesIncreased susceptibility to viral infection * 7 days after infection (day 7 pi) with herpes simplex virus type I (HSV-1), homozygotes have significantly higher HSV-1 titers in the cornea * virus shedding in the tear film is elevated at day 7 pi but not at early points relative to Cxcl9 homozygotes or wild-type controls* mice usually succumb to infection between days 7 and 9 pi",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12"]
[1743,"Bcl-x KO","C57BL/6-Bcl2l1<tm1Dlo>/Wehi",null,"Recessive","Bcl2-like 1","Bcl2l1","Nil","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; targeted mutation 1, Dennis Y Loh","Bcl2l1<tm1Dlo>","MGI:2158303","2",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.","Decreased platelet cell number:* platelet counts are significantly lower than controls (860x10<3>/microliter vs 1100x10<3>/microliter).Abnormal platelet physiology:* platelet half-life is significantly reduced compared to controls (57 hours to 30 hours).","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[1783,"Cathepsin B knockout","B6.129-Ctsb<tm1Jde>/Wehi",null,"Recessive","cathepsin B","Ctsb","Nil",null,"MGI:88561","targeted mutation 1, Jan Deussing","Ctsb<tm1Jde>","MGI:2182129","14",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations are born normal without gross abnormalities. Homozygous mutant has resistance to induced pancreatitis. ",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1762,"E mu-myc","C57BL/6-Tg(IghMyc)22Bri/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 22, Ralph L Brinster","Igh (E mu) enhancer and Myc promoter",{"$nulls":11},"Mice invariably develop lymphomas, 90% succumbing in the first 5 mo of life. to almost invariably develop lymphomas, 90% succumbing in the first 5 mo of life. The tumors typically presented as rapidly progressive lymphadenopathy with thymic involvement and were highly malignant by transplantation assay. Morphologically, they were lymphoblastic lymphomas, usually accompanied by lymphoid leukemia and granulocytosis, and were distinct from the tumors that arose much later in 37% of nontransgenic mice of the same (C57BL/6 x SJL)F2 genetic background.Premature death: mice die at 6 to 15 weeks of age with 94% of mice dying by 4 months of age.Increased tumor incidence: mice occasionally develop thyoma without involvement of peripheral lymphoid organsLeukemia: mice develop multicentric lymphosarcoma associated with leukemia.Lymphoma:* 13 of 15 mice develop lymphomas* mice develop multicentric lymphosarcoma associated with leukemia.B cell derived lymphoma: lymphomas develop from single B-lymphoid clones at different stages of differentiation.Sarcoma: mice develop multicentric lymphosarcoma associated with leukemia.Abnormal lymphopoiesis: mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice.Enlarged spleen: two-fold.Enlarged thymus.Enlarged lymph nodes.","C57BL/6 x SJL","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[1757,"Bmf Deleted Line 372","C57BL/6-Bmf<tm1Anvi>/Wehi",null,"Recessive","Bcl2 modifying factor","Bmf","Normal",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Andreas Villunger","Bmf<tm1Anvi>","MGI:3778609","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[6210,"KO50/266","B6.129S2-Bcl2l11<tm1Ast> Trp53<tm1Tyj>",null,"Recessive","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6210,"KO50/266","B6.129S2-Bcl2l11<tm1Ast> Trp53<tm1Tyj>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod ","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2"]
[3548,null,"C57BL/6-Tg(Cd11c-mOVA) Cst3<tm1Karl>",null,"Recessive","cystatin C","Cst3","Nil","CysC, cystatin C","MGI:102519","cystatin C; targeted mutation 1, S Karlsson","Cst3<tm1Karl>","MGI:2182140","2",{"$nulls":15},"Yes","membrane bound ovalbumin (chicken) mOVA","CD11c (mouse)",{"$nulls":10},"Normal. Transgenic mice express membrane bound ovalbumin under the control of the CD11c promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-30"]
[7761,"Nsun2-GGTC","B6.129-Nsun2<Gt(D014D11)Wrst>/Ausb",null,"Recessive","NOL1/NOP2/Sun domain family member 2","Nsun2","Nil","Misu","MGI:107252","NOL1/NOP2/Sun domain family member 2; gene trap D014D11, German Gene Trap Consortium","Nsun2<Gt(D014D11)Wrst>","MGI:3873208","13",{"$nulls":28},"Alopecia:• cyclic alopecia develops at around 10 months• normal pelage develops after birthAbnormal hair cycle:• a reduced number of hair follicle bulge stem cells are found in S- or G2/M-phase at the initiation of anagen (day 21 of age)• progression of hair follicle cells through the cell cycle is slower• a 2 fold increase in bulge stem cells is found during telogenAbnormal hair cycle anagen phase:• delayed entry of hair follicles into first and second synchronized hair cycleDecreased body size:• appreciably smaller than controlsMale infertility:• males are sterile",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09"]
[5102,"129.Cat-L","129-Ctsl<tm1Cptr>/Wehi",null,"Recessive","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564",null,null,"MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"129","Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2010-04-29"]
[1770,"C3H.Cat-L","C3H-Ctsl<tm1Cptr>/Wehi",null,"Recessive","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"C3H","Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-03"]
[6535,"IR1?","B6.129S2-Ifnar1<tm1Agt>/ScrAusb",null,"Recessive","interferon (alpha and beta) receptor 1 ","Ifnar1","Nil","Ifar, IFN-alpha/betaR, Ifrc","MGI:107658","interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet","Ifnar1<tm1Agt>","MGI:1930950","16",{"$nulls":28},"Abnormal osteoclast morphology:*Osteoclastogenesis is enhanced.Impaired NK cell cytolysis:*Natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells.Decreased interferon-alpha secretion:*Following infection with Leishmania.Decreased interferon-beta secretion:*Following infection with Leishmania.Abnormal response to infection:*Murine cytomegalovirus replication in macrophages is increased greater than 10,000-fold compared to that in wild-type macrophages.Increased tumor growth/size:*In mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice.Decreased bone mineral density",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5152,null,"ENU7B6:039 (ANA)",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6JStdAnu X CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2","1",null,"No","2010-06-11","Cryopreserved sperm"]
[4957,"BALB/c-Homo Rosa EGFP<tg1>","BALB/c-Gt(ROSA)26Sor<tm1(GAP43)Gld> Alpl<tm1(cre)Nagy",null,"Dominant","alkaline phosphatase, liver/bone/kidney","Alpl","Unknown","Akp-2, Akp2, TNAP, TNSALP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Martyn Goulding",{"$nulls":12},"Expression of GFP in all cells.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-18"]
[6905,"APN 259","C57BL/6N-Ift140<tm1a(KOMP)Wtsi>/Marp",null,"Recessive","intraflagellar transport 140 homolog (Chlamydomonas)","Ift140 ","Unknown","mKIAA0590, Tce5, Wdtc2 ","MGI:2146906 ","\tintraflagellar transport 140 homolog (Chlamydomonas); targeted mutation 1a, Wellcome Trust Sanger Institute ","Ift140tm1a(KOMP)Wtsi","MGI:4363217","17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-06-01","Cryopreserved sperm"]
[1771,"Cathepsin-S/Cathepsin-L Knockout","Un-Ctsl<tm1Cptr> Ctss<tm1Hap>/Wehi",null,"Dominant","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","3",{"$nulls":15},"No",{"$nulls":12},"Deficient CD4 T cell generation (but not \"visibly\" immunocompromised). Periodic partial hair loss. ",null,null,"No","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1771,"Cathepsin-S/Cathepsin-L Knockout","Un-Ctsl<tm1Cptr> Ctss<tm1Hap>/Wehi",null,"Dominant","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"No"]
[6225,"Ly5.1/gBT-1/Rel","B6.129-Ptprc<a> Rel<tm1Brv> Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn",null,"Semi-dominant","protein tyrosine phosphatase, receptor type, C","Ptprc","Normal","B220, CD45, Ly-5, Lyt-4, T200 ","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":16},"transgene insertion L118-1, Francis R Carbone",{"$nulls":13},"C57BL/6 then Ly5.1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6225,"Ly5.1/gBT-1/Rel","B6.129-Ptprc<a> Rel<tm1Brv> Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn",null,"Semi-dominant","reticuloendotheliosis oncogene","Rel","Normal","c-Rel","MGI:97897","reticuloendotheliosis oncogene; targeted mutation 1, Rodrigo Bravo ","Rel<tm1Brv>","MGI:3639342","11"]
[1782,"Cathepsin-S Knockout","B6;129-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1809,null,"Cathepsin H knockout",null,"Recessive","cathepsin H","Ctsh","Unknown","Cat H","MGI:107285",{"$nulls":3},"1",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[1810,"Cathepsin W knockout","Un-Ctsw<tm1Ctnp>",null,"Recessive","cathepsin W","Ctsw","Nil","lymphopain","MGI:1338045","cathepsin W; targeted mutation 1, Christine T N Pham","Ctsw<tm1Ctnp>","MGI:3046638","19",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[5173,"Cx40.350 ; Tie2Cx40.350","B6;CBA-Tg(Tie2-Gja5<DN350>)/ABS",null,"Dominant","gap junction protein, alpha 5","Gja5","Increased","connexin 40, Cx40, Gja-5","MGI:95716",{"$nulls":3},"Unknown",{"$nulls":16},"overexpression of Cx40","Tie2 endothelial specific",{"$nulls":10},"Unknown","unknown","N3 B6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","3",null,null,"No","2010-07-06","Cryopreserved sperm"]
[205,"Nkx2-5 KO","C57BL/6-Nkx2-5<tm4Rph>/Apb",null,"Dominant","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Nil","Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","targeted mutation 4, Richard P Harvey","Nkx2-5<tm4Rph>","MGI:3655239","17",{"$nulls":15},"Yes",{"$nulls":12},"Arrested cardiac development, death E9.5-10","atrial septal abormalities, AV conduction defect","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-20","Cryopreserved sperm"]
[1818,"Ts1Cje","B6.Cg-Ts(16C-tel)1Cje",null,"Dominant",null,null,"Unknown",null,null,"trisomy, Chr 12 translocation to Chr 16, Charles J Epstein","Ts(1216)1Cje","MGI:3623022","12",{"$nulls":15},"Yes",{"$nulls":12},"Down Syndrome. Behavioral and learning difficulties.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-06"]
[6227,"B6PLT16","C57BL/6-Bcl2l1<Plt16>",null,"Semi-dominant","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; platelet 16","Bcl2l1<Plt16>","MGI:3847886","2",{"$nulls":28},"Partial prenatal lethality:*Very few fetuses survive until birth.","Decreased platelet cell number:*Platelet counts are significantly lower than controls (596x10<3>/microliter vs 1100x10<3>/microliter).Increased megakaryocyte cell number:*Megakaryocyte numbers are marginally elevated compared to controls.Abnormal platelet physiology:*Platelet half-life is significantly reduced compared to controls (57 hours to 30 hours).","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[1817,"Rac2 knockout","C57BL/6-Rac2<tm1Mddw>/Wehi",null,"Recessive","RAS-related C3 botulinum substrate 2","Rac2","Nil",null,"MGI:97846","targeted mutation 1, Mary C Dinauer and David A Williams","Rac2<tm1Mddw>","MGI:1857701","15",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9",null,null,"No","2007-08-06"]
[1833,"Blimp1 / Rag 2 knockout","C57BL/6-Prdm1<tm1Nutt> Rag2<tm1Fwa>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Blimp-1 homozygotes die late gestation.Rag 2 homzygotes are immunocompromised ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08"]
[1833,"Blimp1 / Rag 2 knockout","C57BL/6-Prdm1<tm1Nutt> Rag2<tm1Fwa>/Wehi",null,"Recessive","recombination activating gene 2","Rag2","Unknown","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2"]
[8579,"Tweak KO/C57BL/6 ","C57BL/6-Tnfsf12<tm1>/Apb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 12","Tnfsf12",null,"APO3L, DR3L, Tweak","MGI:1196259",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-02","Cryopreserved sperm"]
[7762,"Nsun2-EuComm","C57BL/6N-Nsun2<tm1a(EUCOMM)Wtsi>/Ausb",null,"Recessive","NOL1/NOP2/Sun domain family member 2","Nsun2","Nil","Misu","MGI:107252","NOL1/NOP2/Sun domain family member 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Nsun2<tm1a(EUCOMM)Wtsi>","MGI:4432654","13",{"$nulls":28},"Decreased body size:• appreciably smaller than controlsMale infertilitybehavior/neurologicaldecreased grip strength ( J:175295 )\tWTSI (J:175295)hyperactivity ( J:175295 )\tWTSI (J:175295)craniofacialabnormal cranium morphology ( J:175295 )WTSI (J:175295)abnormal tooth morphology ( J:175295 )WTSI (J:175295)abnormal snout morphology ( J:175295 )\tWTSI (J:175295)short snout ( J:175295 )\tWTSI (J:175295)upturned snout ( J:175295 )\tWTSI (J:175295)growth/sizedecreased percent body fat ( J:175295 )\tWTSI (J:175295)decreased total body fat amount ( J:175295 )WTSI (J:175295)abnormal tooth morphology ( J:175295 )WTSI (J:175295)abnormal snout morphology ( J:175295 )\tWTSI (J:175295)short snout ( J:175295 )\tWTSI (J:175295)upturned snout ( J:175295 )\tWTSI (J:175295)decreased lean body mass ( J:175295 )WTSI (J:175295)decreased body weight ( J:165965 , J:175295 )WTSI (J:175295)\tEuPh (J:165965)decreased body length ( J:175295 )WTSI (J:175295)hematopoietic systemincreased erythrocyte cell number ( J:175295 )WTSI (J:175295)decreased mean corpuscular hemoglobin ( J:175295 )WTSI (J:175295)decreased mean corpuscular volume ( J:175295 )WTSI (J:175295)homeostasis/metabolismdecreased circulating glucose level ( J:175295 )WTSI (J:175295)decreased circulating cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating HDL cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating LDL cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating free fatty acid level ( J:175295 )\tWTSI (J:175295)decreased circulating glycerol level ( J:175295 )\tWTSI (J:175295)decreased circulating amylase level ( J:175295 )\tWTSI (J:175295)decreased energy expenditure ( J:175295 )\tWTSI (J:175295)increased energy expenditure ( J:175295 )\tWTSI (J:175295)increased carbon dioxide production ( J:175295 )\tWTSI (J:175295)increased oxygen consumption ( J:175295 )\tWTSI (J:175295)improved glucose tolerance ( J:175295 )\tWTSI (J:175295)integumentabnormal hair cycle anagen phase ( J:175295 )\tWTSI (J:175295)limbs/digits/tailabnormal humerus morphology ( J:175295 )WTSI (J:175295)abnormal deltoid tuberosity morphology ( J:175295 )WTSI (J:175295)skeletonabnormal cranium morphology ( J:175295 )WTSI (J:175295)abnormal humerus morphology ( J:175295 )WTSI (J:175295)abnormal deltoid tuberosity morphology ( J:175295 )WTSI (J:175295)abnormal spine curvature ( J:175295 )WTSI (J:175295)kyphosis ( J:175295 )WTSI (J:175295)lordosis ( J:175295 )\tWTSI (J:175295)decreased bone mineral content ( J:175295 )WTSI (J:175295)decreased bone mineral density ( J:175295 )WTSI (J:175295)abnormal joint morphology ( J:175295 )WTSI (J:175295)vision/eyeabnormal cornea morphology ( J:175295 )WTSI (J:175295)abnormal lens morphology ( J:175295 )WTSI (J:175295)cataracts ( J:175295 )WTSI (J:175295)",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09"]
[7289,"TCRF5","B6(Cg)-Tg(Cd2-TcraF5,CD2-TcrbF5)1Kio/AnuApb","B6(Cg)-Tg(Cd2-TcraF5,CD2-TcrbF5)1KioAnu","Dominant",{"$nulls":25},"transgene insertion 1, Dimitris Kioussis","CD2 minigene",{"$nulls":10},"This clone is CD8+ and recognises amino acids 366-374 of the nucleoprotein (NP 366-374) of influenza virus (A/NT/60/68), in the context of Class I MHC Db (Townsend et al., 1986). The usage of V beta 11 makes this TcR reactive to Class II IE molecules and an endogenous ligand recently identified as a product of the endogenous mammary tumour viruses (Mtv) 8, 9, and 11 (Dyson et al., 1991). The development of F5 transgenic T cells and their function in mice of the appropriate MHC (C57BL/10 H-2b, IE-) or in mice expressing Class II MHC IE (e.g., CBA/Ca H-2k and BALB/c H-2d) and the endogenous Mtv ligands. Positive selection of CD8+ T cells expressing the V beta 11 is seen in C57BL/10 transgenic mice (H-2b). Peripheral T cells from these mice are capable of killing target cells in an antigen-dependent manner after a period of in vitro culture with IL-2. In the presence of Class II MHC IE molecules and the endogenous Mtv ligand, most of the single-positive cells carrying the transgenic T-cell receptor are absent in the thymus. Unexpectedly, CD8+ peripheral T-cells in these (H-2k or H-2d) F5 mice are predominantly V beta 11 positive and also have the capacity to kill targets in an antigen-dependent manner. This is true even following backcrossing of the F5 TcR transgene to H-2d scid/scid mice, in which functional rearrangement of endogenous TcR alpha- and beta-chain genes is impaired.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-03-18","Cryopreserved sperm"]
[4724,"Gpx1 -/-","B6.129-Gpx1<tm1Kola>/MarpApb",null,"Recessive","glutathione peroxidase 1","Gpx1","Unknown","cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1","MGI:104887","targeted mutation 1, Ismail Kola","Gpx1<tm1Kola>","MGI:2388705","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-09","Cryopreserved sperm"]
[1846,null,"Un-Tg(ACTB-ECFP)1Nagy/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion CK6, Andras Nagy","chicken beta actin promoter coupled with the cytomegalovirus (CMV) immediate early enhancer",{"$nulls":10},"Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. All tissues from these animals display fluorescence in all cell types under appropriate lighting conditions, except in erythrocytes and adipocytes where fluorescence is negligible or absent.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[1852,null,"Jaw1 knockout",null,"Recessive","lymphoid-restricted membrane protein","Lrmp","Unknown","D6Int3, D6Int4, D6Int5, D6Int7, D6Int8, Jaw1","MGI:108424",{"$nulls":3},"6",{"$nulls":15},"Yes",{"$nulls":12},"Males are sterile. Females are normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-10"]
[1854,null,"5'endothelial Cre ER-T",null,"Dominant",{"$nulls":25},"Cre recombinase",{"$nulls":14},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[308,"Inbred Athymic Nude","BALB/c-Foxn1<nu>/Arc",null,"Recessive","forkhead box N1","Foxn1","Unknown","D11Bhm185e, Hfh11, whn","MGI:102949","nude","Foxn1<nu>","MGI:1856108","11",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:some mice die within 1 week of birth55% mortality within 2 weeksPremature death:100% mortality by 25 weeksDecreased body size and weight.Postnatal growth retardation.Abnormal T cell differentiation.Athymia.Abnormal cell-mediated immunity.Abnormal liver morphology:liver lobes were atrophied and covered with red scarsvariable degrees of severity, typically increasing with age at time of death.Small ovaryCoiled sperm flagellum: many sperm had coiled tailsAbnormal estrous cycle: many females exhibited continuous dioestrus and metaoestrus phasesFemale infertility: severely reduced fertilityReduced male fertility.Asthenozoospermia.Nude: sparse hair growth around 5 weeks of agein some mice, cephalo-caudal migration of an irregular band of short sparse hairThin skin:reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skinAbsent vibrissae: absent at birthShort and wavy vibrissae: older mice show repeated growth and loss of short and wavy vibrissae.","Have hair. Enlarged thymus","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03"]
[4735,"Analiese","ENU5WT:035",null,"Recessive",null,null,"Unknown",null,null,"Analiese",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"9",null,"No","2009-04-19","Cryopreserved sperm"]
[1853,"PGK-Cre","Un-Tg(Pgk1-cre)1Lni",null,"Dominant",{"$nulls":25},"transgene insertion 1, Peter Lonai","Phosphoglycerate kinase","dominant maternal control",{"$nulls":9},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[7305,"RIP-mOVA","C57BL/6-Tg(Ins2-TFRC/OVA)Wehi/WehiApb",null,"Dominant",{"$nulls":25},"transgene insertion, Walter and Eliza Hall Institute of Medical Research","rat insulin 2",{"$nulls":10},"Normal. Mice express OVA in the pancreas beta cells and kidney proximal tubular cells. There is low level expression in the testes. No thymic expression detected but when crossed to OT-I TCR Tg mice, the OT-I T cells were deleted indicating low levels of OVA expression in the thymus.","Normal","C57BL/6","No","Unknown","Yes","No","Unknown","Yes","No","Good",null,">30","Tg x C57BL/6","No","2013-04-05","Cryopreserved sperm"]
[4543,null,"C57BL/6-Eed<l7Rn5-3354SB>",null,"Recessive","embryonic ectoderm development","Eed","Nil","l(7)5Rn, l7Rn5","MGI:95286","lethal, Chr 7, Rinchik 5, 3354SB","Eed<l7Rn5-3354SB>","MGI:1856856","7",{"$nulls":15},"Yes",{"$nulls":12},"Lethal shortly after implanatation, extra-embryonic tissue defects",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Good","2",null,"Het x WT","No","2009-03-01"]
[6645,"NOD.BID","NOD.B6-Bid<tm1.1Ast>/WehiStvApb",null,"Dominant","BH3 interacting domain death agonist","Bid","Nil","2700049M22Rik","MGI:108093","BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser","Bid<tm1.1Ast>","MGI:4440571","6",{"$nulls":28},"Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas wild-type mice normally die from hepatocellular apoptosis and hemorragic necrosisHomozygous null mice develop spontaneous type 1 diabetes at the same incidence as wild-type NOD mice.","Normal","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","10","Sister x Brother (hom x hom)","Yes","2011-11-14","Cryopreserved sperm"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin alpha chain complex","Hba","Nil",null,"MGI:96014","hemoglobin alpha chain complex; targeted mutation 1, Timothy Townes","Hba<tm1(HBA)Tow>","MGI:3790755","11",{"$nulls":28},"Display sickle cell disease. Mice develop anemia from 3 weeks of age. Lethality occurs at variable rates (after 3 months).  ","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"heterozygous intercrosses","No","2014-04-08","Cryopreserved sperm"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin beta chain complex","Hbb","Nil",null,"MGI:96020","hemoglobin beta chain complex; targeted mutation 2, Timothy Townes","Hbb<tm2(HBG1,HBB*)Tow>","MGI:3790753","7"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin beta chain complex","Hbb",null,null,"MGI:96020","hemoglobin beta chain complex; targeted mutation 3, Timothy Townes","Hbb<tm3(HBG1,HBB)Tow>","MGI:3790756","7"]
[7341,"MommeD43","FVB/NJ-Setdb1<MommeD43> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","SET domain, bifurcated 1","Setdb1","Unknown","ESET, KMT1E, mKIAA0067","MGI:1934229","SET domain, bifurcated 1; modifiers of murine metastable epiallele D43","Setdb1<MommeD43>",null,"3","ENSMUSG00000015697","ENSMUST00000015841","Setdb1-005",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Normal","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm"]
[1731,"Eµ-BCL2-36","B6.Cg-Tg(Bcl2)36Wehi/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 36, Walter and Eliza Hall Institute of Medical Research","Emu immunoglobulin heavy chain enhancer and SV40 promoter.",{"$nulls":11},"Increased B cell number: mutants show an excess of B lymphocytesIncreased T cell number: mutants have an excess of T lymphocytes.Abnormal B cell physiology: * transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes.Increased immunoglobulin level:* mice display increased serum immunoglobulin concentrationsAbnormal T cell physiology:* transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes.Increased susceptibility to autoimmune disorder:* some transgenic mice develop a systemic autoimmune-like disease.T cell derived lymphoma:* a few mice develop fatal clonal T cell tumors.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[4702,"NOD.MRL(C3)-Fas<lpr>/LtJ","NOD.Cg-Fas<lpr>/Apb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.",null,"NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[291,null,"CBA/CaH-Tg(Il5)1Glx",null,"Dominant",{"$nulls":25},"Interleukin 5, IL5","locus control region (LCR) from the gene encoding the T-cell surface antigen CD2",{"$nulls":10}," The IL-5 mice are macroscopically normal apart from an enlarged spleen which contains numerous eosinophiles at various stages of differentiation. Homozygous mice have higher numbers of eosinophils than heterozygotes but are difficult to breed.","Heterozygous mice have about 8 copies of the IL-5 gene and show a life long blood and tissue eosinophilia.","CBA/CaH","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2"]
[4517,"anda","ENU8C:014",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[5154,"RRFUR","BALB/c-FLii<tm1Hdc> Gt(ROSA)26Sor<tm1.1(FLII)Hdc>/AnuApb",null,"Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fliih","MGI:1342286","flightless I homolog (Drosophila); targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Hugh D Campbell","SV40","Human FLII is not expressed until genetic exposure to Cre recombinase",{"$nulls":9},"Normal. Rescue of embryonic lethal phenotype of Flii<tm1Hdc> strain.","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","4",null,"Hom x Hom","No","2010-06-15","Cryopreserved sperm"]
[5215,"mIMPα4FL (very low level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)verylow",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","very low level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-08-30","Cryopreserved sperm"]
[4116,"Crimpy","ENU12WT:012a",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"First coat appears as wavy or crimped. Affected mice shed coat at 3-5 weeks. New coat growth is short, dense and dull. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm"]
[5538,"APN 112","C57BL/6N-Ptpn22<tm1a(EUCOMM)Wtsi>/Marp",null,"Recessive","protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ","Ptpn22","Unknown","70zpep, Ptpn8 ","MGI:107170 ","protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1a, Wellcome Trust Sanger Institute ","Ptpn22tm1a(EUCOMM)Wtsi","MGI:4434268","3",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-07-15","Cryopreserved sperm"]
[5603,"Ancient 2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5605,"Ancient Group 1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5305,"Galectin-3 KO","129/Sv;B6;SJL-Lgals3<tm1Poi>",null,"Recessive","lectin, galactose binding, soluble 3","Lgals3","Nil","gal3, galectin-3, L-34, Mac-2","MGI:96778","lectin, galactose binding, soluble 3; targeted mutation 1, Francoise Poirier","Lgals3<tm1Poi>","MGI:2183057","14",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05"]
[5200,"ZIKO ; Zfp397 KO LacZ","STOCK Zfp397<Gt(W131C06)Wrst>/Apb",null,"Recessive","zinc finger protein 397","Zfp397","Nil",null,"MGI:1916506","zinc finger protein 397; gene trap W131C06, German Gene Trap Consortium","Zfp397<Gt(W131C06)Wrst>","MGI:4123642","18",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2010-08-05","Cryopreserved sperm"]
[8581,"Fn14 KO/C57BL/6 ","C57BL/6-Tnfrsf12a<tm1>/Apb",null,"Recessive","tumor necrosis factor receptor superfamily, member 12a","Tnfrsf12a","Unknown","Fn14, TweakR, TWEAK-R","MGI:1351484",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-02","Cryopreserved sperm"]
[1759,"Bcl-2 KO","C57BL/6-Bcl2<tm1Dlo>/Wehi",null,"Recessive","B-cell leukemia/lymphoma 2","Bcl2","Nil","Bcl-2","MGI:88138","targeted mutation 1, Dennis Y Loh","Bcl2<tm1Dlo>","MGI:2156165","1",{"$nulls":15},"No",{"$nulls":12},"Homozygotes are runted because they develop polycystic kidney disease. They normally die within 6 weeks from birth. They are also profoundly lymphopenic and they turn grey at the second hair follicle cycle because of the death of melanocyte precursors. These defects are corrected by the concomitant loss of Bim.Postnatal lethality: about 50% die between 1 and 6 weeks after birth.Abnormal coat color: hair color turns gray postnatally between 4 and 5 weeks, however skin is normal.Decreased body size.Decreased body weight: body weight is 30-90% of controls.Small ears.Decreased lymphocyte cell number: number of lymphocytes in the peripheral blood, bone marrow, thymus, spleen, and lymph nodes decreases with age, while the number of segmented neutrophils and other hematopoietic lineages is normal.Decreased pre-B cell number: more than 80% reduction of B220+ surface immunoglobulin-negative pre-B cells in the bone marrow.Decreased mature B cell number: more than 80% reduction of B220+/surface immunoglobulin-positive mature B cells in the bone marrow.Decreased CD8-positive T cell number: accelerated decrease over time in the percentage of CD4-CD8+ cells in the periphery.Decreased thymocyte number.Abnormal T cell differentiation.Abnormal kidney morphology: kidneys have a nonsmooth surface, are pale, and exhibit interstitial hyperproliferation.Abnormal kidney cortex: disarray of the cortex structureDecreased renal glomerulus number.Abnormal kidney medulla morphology: disarray of the medulla structure.Small kidney.Dilated renal tubules: dilated renal tubules with hypertrophic epithelium.Polycystic kidney: kidneys exhibit a polycystic appearancerespiratory system.Abnormal nose morphology: rounder nose.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[1811,"K5-mOVA","Un-Tg(K5-mOVA)",null,"Dominant",{"$nulls":25},"membrane bound chicken ovalbumin","Keratin 5",{"$nulls":10},"Normal. Mice express membrane bound ovalbumin in keratinocytes.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[4600,"Epo-R-Cre pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Rb1<tm3Tyj>/Apb",null,"Dominant","retinoblastoma 1","Rb1","Unknown","pRb, Rb, Rb-1","MGI:97874","targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":15},"Yes",{"$nulls":12},"Compound mutant: Mild anaemia.  Single Epo-R-Cre – lethal as homozygous, heterozygous maintained only.  Single pRbfl/fl – no phenotype until Cre exposed",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Epor<tm1(EGFP/cre)Uk> -ve  Rb1<tm3Tyj> female x Epor<tm1(EGFP/cre)Uk> +ve  Rb1<tm3Tyj> het male","No","2009-03-13","Cryopreserved sperm"]
[4600,"Epo-R-Cre pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Rb1<tm3Tyj>/Apb",null,"Dominant","erythropoietin receptor","Epor","Unknown",null,"MGI:95408","erythropoietin receptor; targeted mutation 1, Ursula Klingmuller","Epor<tm1(EGFP/cre)Uk>","MGI:3052727","9"]
[6907,"ENU15NIH49a","C57BL/6JAnu-Satb1<m1Anu>/AnuApb","C57BL/6JAnu-Satb1<m1Anu>/AnuApb","Dominant","special AT-rich sequence binding protein 1","Satb1","Unknown","2610306G12Rik ","MGI:105084","special AT-rich sequence binding protein 1; mutation 1, The Australian National University","Satb1<m1Anu>","MGI:5563413","17","ENSMUSG00000023927","ENSMUST00000144331","Satb1-001","1179","1416","T to A","ENSMUSE00000322390","7","393","Phenylalanine to Leucine",{"$nulls":4},"AAACGAGCCGGAATCTCACAGGCAGTATTTGCACGCGTGGCTTTTAACCGAACTCAGGGAT",{"$nulls":13},"Reduced expression of CD44 on CD4<+> and CD8<+> T cells","Intermediate phenotype of reduced expression of CD44 on CD4<+> and CD8<+> T cells","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"7",null,"No","2012-06-08","Cryopreserved sperm"]
[7343,"MommeD45","FVB/NJ-Klf1<MommeD45> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","Kruppel-like factor 1 (erythroid)","Klf1","Normal","Eklf, Nan","MGI:1342771","Kruppel-like factor 1 (erythroid); modifiers of murine metastable epiallele D45","Klf1<MommeD45>",null,"8","ENSMUSG00000054191","ENSMUST00000067060","Klf1-201",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"GFP transgene  expression levels are increased (suppressor of variegation) in MommeD45.","GFP transgene  expression levels are increased (suppressor of variegation) in MommeD45.","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm"]
[5084,"Cas-L KO","C57BL/6-Nedd9<tm1Miku>/AnuApb",null,"Recessive","neural precursor cell expressed, developmentally down-regulated gene 9","Nedd9","Nil","Cas-L, CasL, E230025G09Rik, HEF1","MGI:97302","neural precursor cell expressed, developmentally down-regulated gene 9; targeted mutation 1, Mineo Kurokawa","Nedd9<tm1Miku>","MGI:3700233","13",{"$nulls":15},"No",{"$nulls":12},"Abnormal B cell number.Increased follicular B cell number: follicular zone B cells (FOB, B-2 cells) are concomitantly increased.Decreased lymphocyte cell number: there are reduced lymphocyte numbers in peripheral lymphoid organs in mutants.Decreased marginal zone B cell number: marginal zone B cell numbers are reduced in mutants, as shown by reduced CD1d<high> cell numbers or IgM<high>IgD<low> cell numbers.Spleen hypoplasia: splenocyte number is ~50% of wild-type; both B and T cell numbers are reduced, with B cells more affected.Lymph node hypoplasia: total number of lymphocytes and numbers of T and B cells is significantly reduced compared to wild-type.Abnormal follicular B cell physiology: follicular zone B cells show aberrant migration and adhesion in response to chemotactic stimuli, compared to wild-type cells.Abnormal leukocyte migration: mutant splenocytes injected into wild-type hosts show abnormal homing with numbers of homing mutant cells found in spleen and lymph nodes decreased compared to wild-type cells.Abnormal T cell physiology: splenic T cells show attenuated responses to chemotactic (CXCL12 and CCL21) stimuli.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-04-09","Cryopreserved sperm"]
[3414,"RIP-mOVA","C57BL/6-Tg(Ins2-TFRC/OVA)296Wehi/wehi",null,"Dominant",{"$nulls":25},"transgene insertion 296, Walter and Eliza Hall Institute of Medical Research","rat insulin 2","Limited to pancreas",{"$nulls":9},"Express membrane bound ovalbumin in pancreas.",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14"]
[5533,"B6NT","C57BL/6-Tg(Nup98-Top1)/MarpApb",null,"Dominant",{"$nulls":25},"Nup98-top1 fusion","Topoisomerase I",{"$nulls":10},"Normal.Normal blood counts at 6mo, no anemia, lymphopenia or thrombocytopenia in mice aged to 600 days","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sibling matings; transgenic male with wildtype female","No","2011-07-07","Cryopreserved sperm"]
[4986,"K14-Frem1","C57BL/6-Tg(KRT14-Frem1)",null,"Dominant",{"$nulls":25},"Fras1 related extracellular matrix protein 1","keratin 14 (K14)",{"$nulls":10},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-01-27","Cryopreserved sperm"]
[5611,"AtF3ko",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5612,"B Arrestin KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4797,"PLJ","PLJ",null,"Dominant",{"$nulls":37},"Normal",null,"PLJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[6904,"APN125","C57Bl/6N-Ptcra<tm2a(EUCOMM)Hmgu>/Marp",null,"Recessive","pre T cell antigen receptor alpha","Ptcra","Unknown","pT-alpha, pT[a], pTalpha","MGI:104857","pre T cell antigen receptor alpha; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH","Ptcratm2a(EUCOMM)Hmgu","MGI:4434686","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-31","Cryopreserved sperm"]
[1980,"Smad1f x Myl2VCre","129;Swiss-Smad<tm2Rob> Myl2<tm1(cre)Krc>",null,"Recessive","MAD homolog 1 (Drosophila)","Smad1","Nil","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":15},"Yes",{"$nulls":12},"Deletion of Smad1 and Myl2 in myosin light polypeptide 2, regulatory, cardia c, slow expressing cells.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04"]
[1980,"Smad1f x Myl2VCre","129;Swiss-Smad<tm2Rob> Myl2<tm1(cre)Krc>",null,"Recessive","myosin, light polypeptide 2, regulatory, cardiac, slow","Myl2","Unknown","MLC-2, MLC-2v, Mlc2v, Mylpc","MGI:97272","myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien","Myl2<tm1(cre)Krc>","MGI:2385922","5"]
[1976,null,"C57BL/6J-TgN(A<2>K<b>HLA)6HsdArc",null,"Recessive",{"$nulls":25},"Human HLA A<2> specific for H-2K<b>?",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2007-09-04"]
[8583,"ASD546:Cazorla","C57BL/6NCrlAnu-Blk<em1Anu>/AnuApb",null,"Recessive","B lymphoid kinase","Blk","Unknown",null,"MGI:88169",{"$nulls":3},"14",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-04","Cryopreserved sperm"]
[7353,"Gnat2c.518A>G","BALB/c-Gnat2<A518G>/MelbApb",null,"Recessive","guanine nucleotide binding protein, alpha transducing 2","Gnat2","Normal","Gnat-2, Gt-2, Tcalpha ","MGI:95779","Gnat2c.518A>G",null,null,"3",{"$nulls":28},"This mouse shows no evidence of cone photoreceptor function as measured by the electroretinogram. This lack of function probably results from a misfolding of the Gnat2 protein. There is also retinal remodelling, opsin mislocalisation by 3 months, increasing in severity by 12 months. At 12 months there is evidence of cone photoreceptor cell loss. At these late ages, there is also evidence of rod phototreceptor functional loss. ","Unknown","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","approximately 4","unknown",null,"No","2013-06-17","Cryopreserved sperm"]
[276,"TgN(IGF-1)","FVB-Tg(Myl1-Igf1)1Nros",null,"Recessive",{"$nulls":25},"transgene insertion 1, Naida Rosenthal"," regulatory elements from the rat myosin light chain (MLC)-1/3 locus","MSkeletal muscle specific",{"$nulls":11},"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-01"]
[1988,"Nkx2-5Cre x Nodal flox","129-Nkx2-5<tm2(cre)Rph> Nodal<tmMku>/Apb",null,"Recessive","Nodal","Nodal","Unknown",null,"MGI:97359",{"$nulls":3},"10",{"$nulls":15},"Yes",{"$nulls":12},"Deletion of Nodal in Nkx2-5 expressing cells.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05","Cryopreserved sperm"]
[1988,"Nkx2-5Cre x Nodal flox","129-Nkx2-5<tm2(cre)Rph> Nodal<tmMku>/Apb",null,"Recessive","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Unknown","Csx, Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","NK2 transcription factor related, locus 5 (Drosophila); targeted mutation 2, Richard P Harvey","Nkx2-5<tm2(cre)Rph>","MGI:2448972","17"]
[1984,"T-box 2","129-Tbx2<tm1Pa>",null,"Recessive","T-box 2","Tbx2","Nil",null,"MGI:98494","T-box 2; targeted mutation 1, Virginia Papaioannou","Tbx2<tm1Pa>","MGI:3505715","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethality during organogenesis: at E12.5 some homozygous embryos are dead.Abnormal atrioventricular canal morphology: at E10.5 the atrioventricular canal fails to constrict in some mutant embryos.   embryonic lethality throughout fetal growth and development.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05"]
[1989,"MesP1Cre x PitX2flox","Un.129-Pitx2<tm1Sac> Mesp1<tm2(cre)Ysa>",null,"Recessive","paired-like homeodomain transcription factor 2","Pitx2","Normal","Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin","MGI:109340","paired-like homeodomain transcription factor 2; targeted mutation 1, Sally Camper","Pitx2<tm1Sac>","MGI:1857844","3",{"$nulls":15},"No",{"$nulls":12},"Deletion of PitX2 in MesP1 expressing cells",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05"]
[1989,"MesP1Cre x PitX2flox","Un.129-Pitx2<tm1Sac> Mesp1<tm2(cre)Ysa>",null,"Recessive","mesoderm posterior 1","Mesp1","Normal","bHLHc5","MGI:107785","mesoderm posterior 1; targeted mutation 2, Yumiko Saga","Mesp1<tm2(cre)Ysa>","MGI:2176467","7"]
[1990,"MesP1Cre x Nodal flox","Un-Nodal<tmMku> Mesp1<tm2(cre)Ysa>",null,"Recessive","nodal","Nodal","Nil",null,"MGI:97359",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Deletion of Nodal gene in cells expressing MesP1.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05"]
[1990,"MesP1Cre x Nodal flox","Un-Nodal<tmMku> Mesp1<tm2(cre)Ysa>",null,"Recessive","Mesoderm posterior 1","Mesp1","Normal","bHLHc5","MGI:107785","mesoderm posterior 1; targeted mutation 2, Yumiko Saga","Mesp1<tm2(cre)Ysa>","MGI:2176467","7"]
[4526,null,"B6.CBA-Tg(hGMCSF-CK1m)394/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm"]
[6774,"DBC2 Flpe ; BRINP2  Flpe","C57BL/6-Brinp2<tm1.2Pib>/PibMarpApb",null,"Recessive","bone morphogenic protein/retinoic acid inducible neural-specific 2","Brinp2","Normal","DBC2, Fam5b, 6430517E21Rik, mKIAA1747","MGI:2443333","bone morphogenic protein/retinoic acid inducible neural-specific 2; targeted mutation 1.2, Phillip I Bird","Brinp2<tm1.2Pib>","MGI:5604617","1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-01-11","Cryopreserved sperm"]
[7247,"MLC:2IGF-1A_1C (Class 2Ea) ; SP2-IGF-1Ea","STOCK Tg(Myl1-Igf1)?Nros/MarpApb",null,"Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain",{"$nulls":10},"Transgenic IGF-1 propeptides are retained in skeletal muscle.E peptides bind to heparin agarose.IGF-1 E peptide moieties bind to extracellular matrix.","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-12-12","Cryopreserved sperm"]
[7374,"CB28-KO","B6.129-Calb1<tm1Mpin>/Apb",null,"Dominant","calbindin 1","Calb1",null,"Brain-2, Calb, Calb-1, calbindin, calbindin-D (28k), CalbindinD28K, CB","MGI:88248","calbindin 1; targeted mutation 1, Max-Planck-Institute for Neurobiology","Calb1<tm1Mpin>","MGI:1857460","4",{"$nulls":28},"Ataxia• mutants do not display ataxia in standard environments; when challenged (with a runway test or rotarod test) coordination is severely disturbed compared to controls• mice display a shaky tremor which usually worsens during movement; controls do not show any tremors","Ataxia• 2-month old heterozygotes show significant deficits in initial trials in a thin horizontal rod test compared to controls but are significantly better than homozygotes; after first 2 sessions, no significant difference remains between mutant groups","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-07-11","Cryopreserved sperm"]
[6612,"ENU19WT 019:G2","ANU:ENU19WT:019:G2",null,"Semi-dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-11","Cryopreserved sperm"]
[7264,null,"Ggn KO (-Neo)",null,"Recessive","gametogenetin","Ggn","Unknown","GGN1, GGN2, GGN3","MGI:2181461",{"$nulls":3},"7",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic Lethal","Appear normal, not studied extensively.","C57BL/6J x129Sv","No","No","Yes","No","No","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-21","Cryopreserved sperm"]
[1995,"TgN(IGF) x Chisel KO","B6.129-Smpx<tm1.1Rph> Tg(IGF1)",null,"Recessive","small muscle protein, X-linked","Smpx","Nil","chisel, Csl","MGI:1913356","targeted mutation 1, Richard P Harvey","Smpx<tm1Rph>","MGI:2387819","X",{"$nulls":15},"Yes","insulin like growth factor 1, IGF 1",{"$nulls":14},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-07"]
[1815,null,"Interferon consensus binding protein knockout",null,"Semi-dominant","interferon regulatory factor 8","Irf8","Unknown","ICSBP, Icsbp1, IRF-8, Myls","MGI:96395",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Lack CD8+ dendritic cells33% moribund by 50 weeks. Haematological neoplasis, develop leukaemia with age.Abnormal haemopoiesis. Increased susceptibility to viral infection .","9% moribund by 50 weeks. Haematological neoplasia.","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[2330,null,"C57BL/6-Prf1<tm1sdz> Ifng<tm1Ts> Tg(TcraTcrb)1100Mjb",null,"Recessive","perforin 1","Prf1","Nil","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-04"]
[2330,null,"C57BL/6-Prf1<tm1sdz> Ifng<tm1Ts> Tg(TcraTcrb)1100Mjb",null,"Recessive","interferon gamma","Ifng","Unknown","Ifg, IFN-gamma","MGI:107656","targeted mutation 1, Timothy Stewart","Ifng<tm1Ts>","MGI:1857184","10"]
[4950,"Light -/- IFNgR -/-","C57BL/6-Tnfsf14<tm1Kpf> Ifngr1<tm1Agt>",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 14","Tnfsf14","Nil","HVEM-L, LIGHT","MGI:1355317","tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Klaus Pfeffer","Tnfsf14<tm1Kpf>","MGI:2671122","17",{"$nulls":28},"In the experimental model of Active EAE we found no significant difference between the LIGHT-/-IFN GAMMA R-/-BL6 strain and the IFN GAMMA R -/-BL6 strain in both the EAE disease development and daily clinical score.  At the time of termination of experimentation the mice from both the experimental groups were of a similar severe level of EAE disease in comparison with the significantly lower level of EAE in the C57/BL6/Wt control mice. There was also no histopathological difference in the brain and spinal cord samples of the two experimental groups at the completion of the EAE experiment.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-04","Cryopreserved sperm"]
[4950,"Light -/- IFNgR -/-","C57BL/6-Tnfsf14<tm1Kpf> Ifngr1<tm1Agt>",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","interferon gamma receptor 1; targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","Unknown"]
[3482,"C57BL/6.CD45 -/-","C57BL/6-Ptprc<tm1Tyb>/Wehi",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Nil","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810","targeted mutation 1, Victor L J Tybulewicz","Ptprc<tm1Tyb>","MGI:3579087","1",{"$nulls":15},"No",{"$nulls":12},"Increased NK cell number:* four- and fivefold increase in the percentage of NK1.1+CD49b+TCR-Beta- NK cells in the spleen and liver, respectively, however percentage of NK precursors was normal.* increase in the turnover of NK cells in the spleen but not liver.Abnormal NK cell physiology:* NK cells secrete less cytokines and chemokines when immunoreceptor tyrosine-based activation motif (ITAM)-containing surface receptors are stimulated.* no calcium flux in NK cells after Ly49D stimulationAbnormal chemokine physiology: Ly49D-stimulated NK cells produce 100-1000-fold less MIP-1alpha and MIP-1beta than controls.Abnormal cytokine secretion: Ly49D-stimulated NK cells secrete less IFN-gamma.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5307,"17FOX 025 B6.129-Tg(FoxP3-GFP)","ENU17FOX:025 Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Hyper-IgE phenotypedetected at 10 weeks of age or later.Cells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-11-08","Cryopreserved sperm"]
[5307,"17FOX 025 B6.129-Tg(FoxP3-GFP)","ENU17FOX:025 Foxp3<tm2Ayr>",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown"]
[5949,"Nodal ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3497,null,"BALB/c-H2<k>",null,"Dominant","histocompatibility-2, MHC","H2","Unknown","H-2, MHC-II","MGI:95894","k variant","H2<k>","MGI:3579322","17",{"$nulls":15},"Yes",{"$nulls":12},"Balb/c is usually H2<d>. The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-24"]
[7380,"Batf3 KO","B6.129-Batf3<tm1Kmm>/MelbAnuApb",null,"Recessive","basic leucine zipper transcription factor, ATF-like 3","Batf3","Nil","9130211I03Rik","MGI:1925491","basic leucine zipper transcription factor, ATF-like 3; targeted mutation 1, Kenneth M Murphy","Batf3<tm1Kmm>","MGI:3817232","Unknown",{"$nulls":28},"Mice that are homozygous for this allele are viable and fertile. Batf3 is highly expressed in CD11c+ CD8α+ conventional dendritic cells (cDCs), with low to absent expression in other immune cells.The deletion of Batf3 prevents development of splenic CD8α+ cDCs, which are important for cross-presentation during infections. Lymph nodes and thymi of Batf3-/- mice lack CD8α+ DCs, and DCs generated from Batf3-/- bone marrow (BM) and spleens are deficient in Toll-like receptor (TLR) 3-induced interleukin (IL)-12 production. These mice also lack CD103+CD11b- DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Exhibiting defects in CD8+T cell response priming, including lack of virus-specific responses, results in the inability to reject highly immunogenic syngeneic tumors.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-07-19","Cryopreserved sperm"]
[6908,"BAC(A33:M2rtTA)","B6;129-Tg(Gpa33-rtTAS*M2)1",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane), Gpa33","Mosaic activity in intestinal epithelium",{"$nulls":9},"Not described","The M2rtTA tet transactivator is expressed in the epithelium of the intestine and colon under the control of the intestine-specific A33 promoter. The expression/activety of the transactivator is mosaic, most likely due to stochastic transgene silencing. Approximately 1 to 5 crypts in the proximal small intestine express the transgene, fewer in the distral intestine and colon.","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-06-14","Cryopreserved sperm"]
[2399,null,"MRL/MpJ",null,"Dominant",{"$nulls":37},"The MRL/MpJ mice are large but docile to the point that males rarely fight. Mice submitted to APB for sperm cryopreservation bred as a control for MRL/MpJ-Faslpr, also exhibit autoimmune disorders but symptoms are manifested much later in life compared to those the MRL/MpJ-Fas<lpr> mice. Starting at about three months of age, levels of circulating immune complexes rise greatly in the MRL-Fas<lpr> mouse but not in the wildtype control, MRL/MpJ. Also beginning at 3 months Fas<lpr> mice exhibit very severe proliferative glomerulonephritis, whereas in the MRL/MpJ controls usually only mild glomerular lesions are detected. The MRL/MpJ lymphoproliferation wildtype females die at 73 weeks of age and males at 93 weeks. This compares to a lifespan of 17 weeks in the female and 22 weeks for males in the mouse homozygous for Fas<lpr>. Mice have increased healing ability.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Sib x Sib","Yes","2007-12-20","Cryopreserved sperm"]
[5107,"Leaden","C57L/JAnuApb",null,"Dominant",{"$nulls":37},"Normal","Normal","C57L/JABS","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-05-03","Cryopreserved sperm"]
[5618,"B6 CX3 CR1 and C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5619,"B6 ngfr P75",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5620,"B6 ROSA26A-EGFP  ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3498,null,"C57BL/6-Phex<ska1>/Wehi",null,"X-linked","phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)","Phex","Unknown","HPDR1","MGI:107489","skeletal abnormality 1","Phex<Ska1>","MGI:2429767","X",{"$nulls":15},"No",{"$nulls":12},"Hypophosphatemia, skeletal abnormalities consistent with rickets, including increased width of unmineralized epiphyseal growth plate, reduced bone width in the central metaphysis, and increased trabecular bone volume in the proximal metaphysis.  Abnormal angulation of the hips and knees. In all affected mice many bones appeared shorter than in wild-type mice and the vertebrae of affected mice were elliptical. In 30 to 50% of affected hemizygous male mice, heterozygous female mice and homozygous female mice, exostoses on the ribs were also observed. Ten of the 11 bone measurements were significantly shorter in mutant mice and appeared independent of sex. Only the mandible length was not significantly shorter. exostoses in bone from affected animals. Ska1 mice had markedly reduced serum phosphate levels and markedly elevated serum alkaline-phosphatase levels, modest reductions in serum calcium were also observed.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-24"]
[4960,"TNAP-Cre","129-Alpl<tm1(cre)Nagy>/AnuApb",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase",{"$nulls":11},"Perinatal lethal","Normal","129","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-01-12","Cryopreserved sperm"]
[5309,"18FOX 010a B6.129-Tg(FoxP3-GFP)","ENU18FOX:010a Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Reduced lymphocyte population / lymphopenia.Phenotype detected by peripheral blood FACS.Cells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-11-08","Cryopreserved sperm"]
[5309,"18FOX 010a B6.129-Tg(FoxP3-GFP)","ENU18FOX:010a Foxp3<tm2Ayr>",null,"Recessive","DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)","Dclre1c",null,"Art, Artemis","MGI:2441769",{"$nulls":3},"2","ENSMUSG00000026648","ENSMUST00000061852","Dclre1c-001","656","743","T to C","ENSMUSE00000319676","8","219","Unknown to Unknown",{"$nulls":4},"TTATGGCTACGAGTATTTATTCACCAACCTAAGCGAGGAGCTGGGAGTTCAGGTTCATGTG","No"]
[3504,"Trif KO","B6.129-Ticam1<tm1Aki>/Wehi",null,"Recessive","toll-like receptor adaptor molecule 1 ","Ticam1","Unknown","TICAM-1, Trif","MGI:2147032","toll-like receptor adaptor molecule 1; targeted mutation 1, Shizuo Akira ","Ticam1<tm1Aki>","MGI:3029019","17",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal interleukin level* severely impaired production of IL12p40 and partiallyDecreased circulating interleukin-6 level * following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholineDecreased susceptibility to endotoxin shock * mice were resistant to LPS-induced shockDecreased susceptibility to viral infection * following exposure to inactivated H5N1 virus, acute-lung injury and IL6 production are attenuated compared to in wild-type miceAbnormal interleukin level * severely impaired production of IL12p40 and partiallyDecreased circulating interleukin-6 level * following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholineDecreased susceptibility to injury * following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance, edema, and serum IL6 levels* following exposure to 1-palmitoyl-2-arachidonoyl-phosphatidylcholine, lung function is improved and IL6 production is decreased compared to in similarly treated wild-type mice",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-25"]
[323,"NOD-Scid","NOD.CB17-Prkdc<scid>",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, DNPK1, HYRC1, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":12},"Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Homozygotes have severe combined immunodeficiency.No endogenous T- or B- Lymphocyte function. Most homozygotes have no detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Thymus, lymph nodes, and splenic follicles are virtually devoid of lymphocytes (Lymphopenia).  They have hypogammaglobulinemia, and a normal hematopoietic microenvironment. Normal antigen-presenting cell, myeloid, and NK cell functions are strain dependent. Scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. Develops high incidence of thymoma with age.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-05"]
[2449,null,"Pardon",null,"Recessive","cadherin 23 (otocadherin)","Cdh23","Unknown","ahl, ahl1, bob, mdfw, nmf112, nmf181, nmf252, USH1D","MGI:1890219",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Mutant mice exhibit circling behavior, tilting of the head and are deaf.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14"]
[7050,null,"B6.129P2-Lipe<tm1Rze>/MarpApb",null,"Recessive","lipase, hormone sensitive","Lipe","Unknown","4933403G17Rik, HSL","MGI:96790","lipase, hormone sensitive; targeted mutation 1, Rudolf Zechner","Lipe<tm1Rze>","MGI:2388334","7",{"$nulls":28},"Abnormal lipid level: diglycerides accumulate in brown fat, white fat, testes, skeletal muscle, and cardiac muscle.Abnormal fatty acid level: shift from reduced short chain fatty acids to elevated long chain fatty acids is seen in the white fat.Abnormal triglyceride level:in white fat the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased.Decreased triglyceride level: decreased by about 70% in cardiac muscle compared to controls.Decreased liver triglyceride level:decreased by about 90% compared to controls.Increased triglyceride level: increased by about 30% in brown fat compared to controls.Abnormal metabolism: * decrease in the formation of free fatty acids in white and brown fat, skeletal and cardiac muscle, liver, and brain * reduced capacity for hydrolysis of diglycerides in all tissue examined * reduced capacity for hydrolysis of triglycerides only in white fat and testesAbnormal brown adipose tissue physiology: diglycerides accumulate in brown fatAbnormal white adipose tissue physiology: * diglycerides accumulate in white fat * the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-08-20","Cryopreserved sperm"]
[1554,null,"BALB/c-Stat6<tm1Aki> Tg(iFABPp-IL9) ",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Unknown",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No","interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[2451,null,"Tsavo",null,"Recessive","transmembrane channel-like gene family 1","Tmc1","Unknown","Beethoven, Bth","MGI:2151016",{"$nulls":3},"19",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice are characterized by progressive degeneration of the cochlear inner hair cells and concomitant deafness. Different alleles causing progressive deafness or profound congenital deafness",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14"]
[7395,"B6-Lym1","B6.BALB/c-Nfkb2<Lym1>/WehiAnuApb",null,"Recessive","nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100","Nfkb2","Unknown","NF kappaB2, p52","MGI:1099800","nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Lym1","Nfkb2<Lym1>","MGI:4412046","19",{"$nulls":28},"Increased circulating lymphocytes.A comprehensive histopathological analysis of these mice, however, revealed an absence of peripheral LN (inguinal, brachial, axillary, cervical) and Peyer’s patches. Mesenteric LN were present, but were reduced in size and cellularity.presence of inflammatory cell infiltrates in the lung and liver.The number of mature recirculating B cells was significantly reduced.Nfkb2<Lym1/Lym1> bone marrow was almost completely unresponsive to RANKL with osteoclast formation <0.5% of that seen with wt.Mild osteopetrosis, with significantly increased trabecular bone volume","The ability of Nfkb2<Lym1/+> cells to form osteoclasts in response to RANKL stimulation was significantly reduced","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2013-08-12","Cryopreserved sperm"]
[4448,"APN16","B6;129-Dusp4<Gt(XG164)Byg>/MIMR",null,"Recessive","Dual specificity phosphatase 4","Dusp4","Unknown","MKP2","MGI:2442191","dual specificity phosphatase 4; gene trap XG164, BayGenomics","Dusp4<Gt(XG164)Byg>","MGI:4127030","8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1","0",null,"No","2009-02-20","Cryopreserved sperm"]
[2454,null,"ENU6PH:043",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":15},"No",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14","Cryopreserved sperm"]
[3593,null,"C57BL/6.129-Tcra<tm1Mom>",null,"Recessive","T-cell receptor alpha chain","Tcra","Nil","Tcr alpha, Tcralpha","MGI:98553","targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous mice for the Tcra<tm1Mom> targeted mutation are viable and fertile. They are deficient in the alpha beta T-cell receptor. The thymus is devoid of CD4+CD8- and CD4-CD8+ cells. Normal numbers of CD4+CD8+ cells are retained without the IL2 receptor. There are normal numbers of CD4-CD8- cells. ~1% of the thymocytes express the gamma delta TCR. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age. Increased susceptibility to bacterial infection    •  greatly increased susceptibility to infection with Mycobacterium paratuberculosis. Older mice may have digestive system problems including ulcers and diarrhea.   They will have an impaired immune response but should remain healthy under clean conditions ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06"]
[4962,"Ccr1 +/+","129-Ccr1<WT>",null,"Recessive","chemokine (C-C motif) receptor 1","Ccr1","Nil","Cmkbr1, MIP-1 alphaR, Mip-1a-R","MGI:104618",{"$nulls":3},"9",{"$nulls":15},"No",{"$nulls":12},"Normal.Control for Ccr1 knockout mouse.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-13","Cryopreserved sperm"]
[2803,"C57BL/6.Max 41","C57BL/6-Tg(IghMAX)41Wehi/Wehi ",null,"Dominant",{"$nulls":25},"human Max","5' intronic enhancer Eu of the immunoglobulin heavy chain locus",{"$nulls":10},"Excess granulocytes, B cell deficiency, thymic lymphoma.Maximal severity of phenotype according to age.Approx. 30% thymic lymphomas at 6-12 wks.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-02-22"]
[4926,null,"B6;129-Gfpt2<Gt(352F9)Cmhd>/Apb",null,"Recessive","glutamine fructose-6-phosphate transaminase 2","Gfpt2","Unknown","GFAT2","MGI:1338883","glutamine fructose-6-phosphate transaminase 2; gene trap 352F9, Centre for Modeling Human Disease","Gfpt2<Gt(352F9)Cmhd>","MGI:4965721","11",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-11-11","Cryopreserved sperm"]
[5441,"Men1 del/wt (Martin C)","B6.129T2-Men1<tm2.1Gfk>/Apb","B6.129T2-Men1<tm2.1Gfk>","Recessive","multiple endocrine neoplasia 1","Men1","Nil","menin","MGI:1316736","multiple endocrine neoplasia 1; targeted mutation 2.1, Graham F Kay","Men1<tm2.1Gfk>","MGI:3810641","19",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal","Tumours with age predominantly in pancreas, pituitary and parathyroids.","C57BL/6","No","No","Yes","No","No","Yes","No","Good","14","1","heterozygote cross wildtype","No","2011-02-17","Cryopreserved sperm"]
[3626,null,"B6.129S4-IL2ra<tm1Dw>",null,"Recessive","interleukin 2 receptor, alpha chain","Il2ra","Nil","CD25, IL-2R alpha chain, Il2r, Ly-43","MGI:96549","targeted mutation 1, Dennis M Willerford","Il2ra<tm1Dw>","MGI:1857192","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.",null,"C57BL/6 x 129","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12"]
[6913,"ENU23:G1","ANU:ENU23:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm"]
[1552,null,"BALB/c-IL4R<tm1> Tg(iFABPp-IL9)",null,"Recessive","interleukin 4 receptor, alpha","Il4ra","Unknown","CD124, IL-4 receptor alpha chain, Il4r","MGI:105367",{"$nulls":3},"7",{"$nulls":15},"Yes","Interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[6911,"ENU22:G1","ANU:ENU22:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm"]
[7409,"Amigo2 KO ; TF3111","B6.129/SvEv-Amigo2<Gt(AI415330)tac>/TacAnuApb",null,"Recessive","adhesion molecule with Ig like domain 2","Amigo2",null,null,"MGI:2145995",{"$nulls":3},"15",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-08-22","Cryopreserved sperm"]
[7435,"CSTCR","C.B6-Thy1<a> Tg(TcraTcrbYA26)1/QimrAnuApb",null,"Dominant","thymus cell antigen 1, theta","Thy1",null,"CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":16},"tansgene insertion 1, Fidel Zavala",{"$nulls":11},"The mice express a monoclonal TCR specific for SYVPSAEQI in context of H2Kd – these particular mice are backcrossed to Thy1.1",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-09-16","Cryopreserved sperm"]
[4867,"TNAP:Cre ; TC","BALB/c-Alpl<tm1(cre)Nagy> ",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase","TNAP",{"$nulls":10},"Embryonic Lethal",null,"BALB/c x C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-25"]
[3326,"Chop KO","C57BL/6-Ddit3<tm1Mori>/Wehi",null,"Recessive","DNA-damage inducible transcript 3","Ddit3","Nil","C/EBP homoologous protein 10, chop, CHOP-10, CHOP10, gadd153","MGI:109247","targeted mutation 1, Masakata Mori","Ddit3<tm1Mori>","MGI:2179046","10",{"$nulls":15},"Yes",{"$nulls":12},"Original mutant on 129/C57BL/6 background had larger brains. Decrease neuronal apoptosis in vivo and in vitro.On C57BL/6 background: kidney epithelium, macrophages and thymocytes are resistant to ER stress induced apoptosis.Males are aggressive.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het x WT C57BL/6","No","2008-06-15"]
[5144,"ENU15CHINA:002","C57BL/6JAnu-Gmds<m1Anu>/AnuApb","C57BL/6JAnu-Gmds<m1Anu>/AnuApb","Recessive","GDP-mannose 4, 6-dehydratase","Gmds",null,null,"MGI:1891112","GDP-mannose 4, 6-dehydratase; mutation 1, The Australian National University","Gmds<m1Anu>","MGI:5563466","13","ENSMUSG00000038372","ENSMUST00000041859","Gmds-001","561","692","T to A","ENSMUSE00000282995","6","187","Tyrosine to STOP",{"$nulls":4},"CCCTATGGAGCAGCCAAACTCTATGCCTATTGGATTGTGGTGAATTTCCGTGAAGCTTATA","Yes",{"$nulls":12},"Highly activated T cells, expansion of myeloid cells.High CD44<+> B and T cells, Low T cells, Low NK cells.","Unknown","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Poor",null,"2",null,"No","2010-05-28","Cryopreserved sperm"]
[5261,"Col1-EphB4 Tg","C57BL/6-Tg(Col1a1-EphB4)1Mat",null,"Dominant",{"$nulls":25},"Mouse Eph receptor B4","collagen, type I, alpha 1 (Col1a1)","Restricted to osteoblasts",{"$nulls":9},"EphB4 transgenic mice expressed 6.7-fold higher levels of Ephb4 transcripts in calvaria and 4.8-fold higher in the long bones as measured by RT-PCR.EphB4 transgenic mice exhibited increased bone mass by 10 weeks of age.Quantitative bone histomorphometry further showed that bone volume, osteoid thickness, mineralizing surface, and bone formation rate were significantly increased in transgenic mice versus wild-type controls (Figure 7C). Serum levels of osteocalcin, a marker of bone formation, were also slightly elevated in EphB4 transgenic mice.Osteoclast number, osteoclast surface, and eroded surface were significantly reduced in EphB4 transgenic mice compared towild-type controls, indicating that osteoclast function was inhibited in these mice.EphB4 transgenic mice showed a decrease in urinary deoxypyridinoline (DPD) crosslinks, a marker for osteoclastic bone resorption, indicating that osteoclast function was suppressed. Such reduced osteoclastic activity is not due to reduction in RANKL or M-CSF or to an increase in OPG since there was no significant difference in Rankl, Csf1, and Opg mRNA levels in bone or RANKL and OPG levels in serum between wild-type and EphB4 transgenic mice.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-21"]
[5288,"B6.PAR1.KO","C57BL/6-F2r<tm1Ajc>",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality during organogenesis: * approximately 50% of homozygotes die between E9.0-10.0. * the remaining 50% survive to adulthood and appear grossly normal. * similar frequencies of embryonic lethality are observed in the C57BL/6J and 129/Sv inbred backgrounds.Abnormal cardiovascular system physiology: * at E8.5, homozygotes have beating hearts and a functional vitelline circulation. * by E9.5, approximately half of the mutant embryos display no heart beat.Abnormal cell physiology: notably, in contrast to platelets, homozygous mutant fibroblasts lack thrombin-induced responses.Decreased embryo size: * at E8.5, homozygotes are morphologically indistinguishable from wild-type embryos. * starting at E9.0, mutant embryos become uniformly smaller than wild-type embryos.Abnormal placenta development: at E9.0 and thereafter, homozygotes display a delay in placental development.Embryonic growth retardation: at E9.0 and thereafter, homozygotes display a global developmental delay.Hematopoietic system phenotype: * surviving homozygotes display normal tail bleeding times and no bleeding diathesis relative to wild-type. * in addition, mutant platelets display strong thrombin-induced responses.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[3339,"cbfa2t3 -/-","C57BL/6-Cbfa2t3<tm1.1DCal>/Apb",null,"Recessive","core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)","cbfa2t3","Nil","ETO-2, MTGR2","MGI:1338013",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"Hom x Hom","Yes","2008-06-20","Cryopreserved sperm"]
[7051,"Aire x Met-Kb","STOCK-Aire<tm1> Tg(sMt1-H2-K<b>)",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire",null,null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":16},"mouse H2-K<b> (MHC class I)","Sheep metallothionein promoter","variable and slightly lower than wild type H2-K<b>. Expression can be induced with Zinc",{"$nulls":9},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"No","2012-08-20"]
[4963,"Sall-GFP","B6.129-Sall1<tm3Ryn>/Apb",null,"Dominant","sal-like 1 (Drosophila)","Sall1","Normal","Msal-3","MGI:1889585","sal-like 1 (Drosophila); targeted mutation 3, Ryuichi Nishinakamura","Sall1<tm3Ryn>","MGI:3603818","8",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal","Normal.GFP labelled Sall1 structures in embryonic kidney.","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2010-01-15","Cryopreserved sperm"]
[6200,"CD14","B6.129S-CD14<tm1Frm>/J",null,"Recessive","CD14 antigen","Cd14    ","Nil",null,"MGI:88318","CD14 antigen; targeted mutation 1, Mason W Freeman","Cd14<tm1Frm>","MGI:1934009","18",{"$nulls":28},"Pulmonary edema:*Less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation.Abnormal cytokine level:*Keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide.*Macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide.      Abnormal interleukin level:      *Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide.      Abnormal tumor necrosis factor level:      *TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide.Increased bone mineral content:*Greater mineral content.Increased bone mineral densityIncreased bone mass:*Increased bone area of the tibia.Decreased susceptibility to bone fracture:*Bones resistant to fracture.Pulmonary edema:*Less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation.Decreased total body fat amountIncreased lean body mass",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6204,"IFNg ","B6.129S7-Ifng<tm1Ts>/J ",{"$nulls":3},"  ifng    ",{"$nulls":35},"\"Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a \"\"clean\"\" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.   Increased sensitivity to xenobiotic induced morbidity/mortality Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU)  Increased susceptibility to bacterial infection induced morbidity/mortality Die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459) Increased susceptibility to parasitic infection induced morbidity/mortality Most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts   (MGI Ref ID J:50832) \"",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6915,"ENU25:G2","ANU:ENU25:G2",null,"Recessive",{"$nulls":37},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2012-06-22","Cryopreserved sperm"]
[6914,"ENU25:G1","ANU:ENU25:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm"]
[6912,"ENU24:G1","ANU:ENU24:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm"]
[844,"SW{HEL}-L ; LC2 Ig","C57BL/6-Tg(IgkHyHEL10)1Rbr",null,"Dominant",{"$nulls":25},"transgene insertion 1, Robert Brink",{"$nulls":11},"B cells express immunoglobulin light chain that recognises hen egg lysozyme.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23"]
[3407,"MHCII I-A<b> o/o","B6.129-H2-Ab1<tm1Doi>/Wehi",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Nil","A beta, Abeta, H-2Ab, H2-Ab, I-A<b>, I-Abeta, Ia-2, Ia2, IAb, Rmcs1","MGI:103070","histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis","H2-Ab1<tm1Doi>","MGI:1927483","17",{"$nulls":15},"Yes",{"$nulls":12},"MHC II-deficient mice do not develop CD4 (helper) T cells. This results in impaired cellular and antibody mediated immune responses. Mice do not appear different to C57BL/6 mice when housed in a clean environment.  IA/IA mice seem to breed more robustly when first mated at an older age (12 weeks) rather than the standard 8 weeks (observation G. Davey)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13"]
[7053,"A33 hfneo","B6;129/Sv-Gpa33<tmhfneo>/LudApb",null,"Recessive","glycoprotein A33 (transmembrane)","Gpa33","Unknown","2010310L10Rik, 2210401D16Rik, A33 antigen","MGI:1891703",{"$nulls":3},"1",{"$nulls":28},"This strain shows no phenotypic signs different from wildtype","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-08-21","Cryopreserved sperm"]
[4967,"B6-HIPCre","B6.NOD-Tg(INS-cre)2Rms/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Robyn M Slattery","human insulin promoter","beta islet cells",{"$nulls":9},"The human insulin promoter (INS) drives cre expression in beta islet cells. Resistance to development of diabetes and hyperglycemia",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-15","Cryopreserved sperm"]
[7467,"Bm1.OT-1","B6.C-H2<bm1> Tg(TcraTcrb)1100Mjb/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1100, Michael J Bevan","H-2K<b> promoter",null,"histocompatibility 2, K region","H2-K",null,null,"MGI:3040519","histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17","Transgenic mice on a C57BL/6 background are somewhat immunodeficient, and may be used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen.Carry OVA-specific, H-2K<b>-restricted T cell receptor","Normal","B6.C-H2<bm1>/ByJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2013-10-29","Cryopreserved sperm"]
[7450,"Lifr fl","B6NTac;B6N-Lifr<tm1a(EUCOMM)Hmgu>/HTacAnuApb",null,"Dominant","leukemia inhibitory factor receptor","Lifr","Normal","A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788","leukemia inhibitory factor receptor; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Lifr<tm1a(EUCOMM)Hmgu>","MGI:4841519","15",{"$nulls":28},"Normal",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-10-04","Cryopreserved sperm"]
[5617,"B57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3418,"Max.OT-1 transgenic","C57BL/6-Tg(TcraTcrb)1100Mjb Tg(IghMAX)Wehi/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1100, Michael J Bevan",{"$nulls":11},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice.  Max.OT-I T cells are highly diabetogenic when transferred into RIP-mOVA mice.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14"]
[{"$nulls":30},"transgene insertion 1100, Michael J Bevan"]
[6231,"Bak/vavbcl69","B6.129-Bak1<tm1Thsn> Tg(Vav-BCL2)1Jad",null,"Semi-dominant","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":16},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","Overexpression",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5622,"B6;129P2-Omp<tm(cre)Mom>MomJ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6234,"Bax/Bmf","B6.129-Bax<tm1Sjk> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":28},"Male sterility in -/-. Otherwise, grossly normal. Most -/- mice have grey fur compared to +/- and +/+ which are black.  Double -/- males should be infertile.",null,"129/Sv","Yes","Unknown","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6234,"Bax/Bmf","B6.129-Bax<tm1Sjk> Bmf<tm1Rjd>",null,"Recessive","BCL2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7"]
[6805,"tenascin C KO","129/Sv-Tnc<tm1Ref>/MelbApb",null,"Recessive","tenascin C","Tnc","Nil","C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C","MGI:101922","tenascin C; targeted mutation 1, Reinhard Fassler","Tnc<tm1Ref>","MGI:2148541","4",{"$nulls":28},"No abnormal phenotype.","No abnormal phenotype.","129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-01-31","Cryopreserved sperm"]
[4799,"Dimit; ENU13NIH:039ab","C57BL/6JAnu-Ighd<dmit>/AnuApb","C57BL/6JAnu-Ighd<dmit>/AnuApb","Recessive","immunoglobulin heavy constant delta","Ighd","Unknown","IgD","MGI:96447","dimit","Ighd<dmit>","MGI:4819235","12","ENSMUSG00000076616","ENSMUST00000103424","Igh-5-201","241","241","T to A","ENSMUSE00000663372","1","74","Isoleucine to Lysine",{"$nulls":4},"CAGAACTGAACCTCAACCACACTTGCACCATAAATAAACCCAAAAGGAAAGAAAAACCTTT","Yes",{"$nulls":12},"Shifted IgD expression measured by flow cytometry",null,"C57BL/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-10","Cryopreserved sperm"]
[4588,"Seshat ; ENU11B6:169b","C57BL/6JAnu-Cd4<sesh>/AnuApb","C57BL/6JAnu-Cd4<sesh>/AnuApb","Recessive","CD4 antigen","Cd4","Unknown","L3T4, Ly-4","MGI:88335","seshat","Cd4<sesh>","MGI:4819228","6","ENSMUSG00000023274","ENSMUST00000024044","Cd4-001","374","543","T to C","ENSMUSE00000246632","4","125","Valine to Alanine",{"$nulls":4},"GAACAGGAAAGAGGAGGTGGAGTTGTGGGTGTTCAAAGTGACCTTCAGTCCGGGTACCAGC","Yes",{"$nulls":12},"Reduced T cell numbers in peripheral blood. Reduced CD4 expression.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-11","Cryopreserved sperm"]
[6916,"FVBNJ-Momme D23","FVB/NJ-Smchd1<MommeD23> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SMC hinge domain containing 1","Smchd1",null,"4931400A14Rik, mKIAA0650, MommeD1","MGI:1921605","SMC hinge domain containing 1; modifiers of murine metastable epiallele D1","Smchd1<MommeD23>",null,"17",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human α-Globin (-570 to +37) (4.1kb of enhancer)","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm"]
[3624,null,"B6.CBA-Tg(Pou5f1-EGFP)",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Enhanced green fluorescent protein (GFP)","Pou domain, class 5, transcription factor 1 (Pou5f1)",{"$nulls":10},"Expression of GFP in primordial germ cells",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12"]
[6256,"CBA.nu","CBA-Foxn1<nu>/Wehi",null,"Recessive","forkhead box N1","Foxn1","Nil","D11Bhm185e, Hfh11, whn","MGI:102949","forkhead box N1; nude ","Foxn1<nu>","MGI:1856108","11",{"$nulls":28},"Partial postnatal lethality:*Some mice die within 1 week of birth*55% mortality within 2 weeksPremature death:*100% mortality by 25 weeksSmall ovaryDecreased body size      Decreased body weightPostnatal growth retardationAbnormal liver morphology:*Liver lobes were atrophied and covered with red scars.*Variable degrees of severity, typically increasing with age at time of death.Coiled sperm flagellum:*Many sperm had coiled tails.Abnormal estrous cycle:*Many females exhibited continuous dioestrus and metaoestrus phasesFemale infertility:*Severely reduced fertility.Reduced male fertilityAsthenozoospermiaDecreased leukocyte cell numberAthymiaHairless*Sparse hair growth around 5 weeks of age.*In some mice, cephalo-caudal migration of an irregular band of short sparse hair.Absent vibrissae:*Absent at birth.Short vibrissae:*Older mice show repeated growth and loss of short and wavy vibrissae.Wavy vibrissae:*Older mice show repeated growth and loss of short and wavy vibrissae.Thin skin:*Reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin.",null,"CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5158,"4AT22 ; ANNA","ENU4AT:022",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Anti-nuclear antibodies, high.Both young and older mice.","Normal","C57BL/6 x B10BR X CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-06-25","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[6917,"FVBNJ-Momme D35","FVB/NJ-Smarca5<MommeD35> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5","Smarca5",null,null,"MGI:1935129",{"$nulls":3},"8",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of enhancer region","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm"]
[1823,"MHC II-EGFP","C57BL/6-Tg(MHCII-EGFP)",null,"Dominant",{"$nulls":25},"MHC class II tagged with Green fluorescent Protein",{"$nulls":11},"Normal.MHC II positive cells are fluorescent (EGFP+).Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[5417,"A33:Lgp130YFKO ; line 6 backcross (ME-248)","CB;129-Tg(Gpa33-Il6st*)6Ern/Lud",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-02-04","Cryopreserved sperm"]
[6257,"CD40K","B6.129P2-Cd40<tm1Kik>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","CD40 antigen; targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":28},"Hematopoietic system phenotype*Normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles.Abnormal dendritic cell physiology:*Impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7.*Impaired priming of IFN-gamma producing T cells.Increased susceptibility to bacterial infection:*Increased susceptibility to aerosol Mycobacterium tuberculosis infection.*Increased bacterial loads in lung and spleen.*40% of infected mice moribund 3 - 4 weeks postinfection.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6270,"ERTF5/TOM","ERTF5-rttA3-GFP/Tet-O c-myc",{"$nulls":3}," ERTF5TA    c-myc   ",{"$nulls":35},"Contact Researcher  This strain carries the human c-myc gene and the rttA3-IRES-GFP cassette which are controlled by the Tet/O and the ERTF5 promoter respectively.   The expression of myc is induced in ERTF5 expressing cells only in the presence of doxycycline.   No Special monitoring required (This stain should not have any obvious phenotype without treatment of doxycycline.)  DOX - The phenotypes of this strain with treatment of doxycycline remain unknown. But this strain may potentially develop tumors in certain tissues upon treatment with doxycycline. ",null,"FVB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4848,"Lenie","ENU6AT:32",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[5621,"B6 ROSAeGFPxCol1a2 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6918,"FVBNJ-Momme D36","FVB/NJ-Smchd1<MommeD36> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SMC hinge domain containing 1","Smchd1",null,"4931400A14Rik, mKIAA0650, MommeD1","MGI:1921605","SMC hinge domain containing 1; modifiers of murine metastable epiallele D36","Smchd1<MommeD36>",null,"17",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of enhancer region","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm"]
[7457,"C2(129)","129X1-Cited2<tm1Jpmb>/VccriApb","129X1-Cited2<tm1Jpmb>","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Nil","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1, Juan Pedro Martinez Barbera","Cited2<tm1Jpmb>","MGI:2176158","10",{"$nulls":15},"No",{"$nulls":12},"Embryos die during gestation (~E15.5). Heart, left-right axis, neural tube, adrenal gland and placental defects.","None","129X1","No","No","Yes","No","No","Yes","No","Good","10","0","C2B6∆ +/- (heterozygous) mated with 129X1","No","2013-10-22","Cryopreserved sperm"]
[40,"Flipper","B6;NODAnu-Chkb<flp>/AnuApb","B6;NODAnu-Chkb<flp>/AnuApb","Recessive","choline kinase beta","Chkb","Unknown","Chetk, Chkl, CK/EK-beta","MGI:1328313","flipper","Chkb<flp>","MGI:3847123","15","ENSMUSG00000022617","ENSMUST00000023289","Chkb-201","1","1","A to T","ENSMUSE00000322690","1","1","Methionine to Leucine",{"$nulls":4},"ATGGCGGCAGACGGGACAGGGGTAGTCGGAGG","No",{"$nulls":12},"Homozygotes develop shortened and lateral rotation (valgus?) of radius and ulna leading to short and splayed forelegs. Female homozygotes can breed. Male homozygotes die suddenly during mating with haemorrhages in seminiferous glands (this is currently being re-investigated). Some homozygotes also develop perineal hernias.Chkb<rmd> Homozygous null mice display progressive muscular weakness and dystrophy in the hindlimbs but have normal nerve and neuromuscular junction morphology.",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[7480,"PbT-I-25/Ly5.1 ; C57BL/6-Tg(TCRaB4-46TcrbB4-46)25Cbn","C57BL/6-Ptprc<a> Tg(H2-K<b>-Tcra,-Tcrb)25Cbn/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 25, Francis Carbone","H-2Kb",null,"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","Majority of CD8 T cells express the transgenic T cell recepter Va8Vb10 specific for Plasmodium berghei (Pb) parasites.","As for homozygous","C57BL/6","Yes","Yes","Yes","Unknown","Unknown","Unknown","No","Excellent",null,"4","brother-sister","No","2013-11-14","Cryopreserved sperm"]
[5625,"B6.126Tg(myh6-cre/Ers1)1Jmk/J Cardiac Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5627,"B6.129-Tg(APPSw)40Btla/J ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2444,"Lightning ; ENU8B6:045","C57BL/6-Ptprc<ltng>/AnuApb","C57BL/6-Ptprc<ltng>/Apb","Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; lightening","Ptprc<ltng>","MGI:4441612","1","ENSMUSG00000026395","ENSMUST00000027645","Ptprc-201","1583","1681","T to C","ENSMUSE00000595907","14","528","Phenylalanine to Serine",{"$nulls":4},"TACAAAATACAACAAGACAAACTGTCAGTTTTATGTAGATAATCTCTACTATTCAACTGAC","No",{"$nulls":12},"Homozygous null mutants have defective T-cell maturation.Decreased CD4-positive T cell number: SP4 thymocytes are reduced compared to in wild-type mice.Abnormal T cell differentiation: * mice exhibit enhanced negative selection compared with wild-type mice. * positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc<tm1Mak> homozygotes.Decreased double-positive T cell number.Thymus hypoplasia.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14","Cryopreserved sperm"]
[8477,"Traj18 KO","BALB/c-Traj18<em1>/Apb",null,"Recessive","T cell receptor alpha joining 18","Traj18","Nil","Gm17009","MGI:4440521",{"$nulls":3},"14",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-27","Cryopreserved sperm"]
[8355,"Srsf3-UbcCreERT2-RFP","C57BL/6N-Srsf3<tm1a(KOMP)Mbp> Tg(UBC-cre/ERT2)1Ejb Tg(RFP)/Apb",null,"Recessive","serine/arginine-rich splicing factor 3","Srsf3",null,"Sfrs3, X16","MGI:98285","serine/arginine-rich splicing factor 3; targeted mutation 1a, Mouse Biology Program, UCDavis","Srsf3<tm1a(KOMP)Mbp>","MGI:4462527","17",{"$nulls":16},"transgene insertion 1, Eric J Brown","human ubiquitin C ",{"$nulls":10},"Constitutive expression of RFP, tamoxifen inducible Srsf3 knockout, no phenotype until induced.","See above","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 1, Eric J Brown","human ubiquitin C "]
[3423,"RIP-EYFPss","C57BL/6-Tg(Ins2-EYFP/OVA{257-264}/gB{498-505})/Wehi",null,"Dominant",{"$nulls":25},"yellow fluorescent protein (YFP) linked to two class I epitopes: one from OVA (OVA{257–264}) and one from Herpes simplex virus-1 glycoprotein B (gB{498–505})","Rat insulin 2",{"$nulls":10},"Transgenic mice expressing a hybrid fusion protein under the control of the rat insulin promoter (RIP). This hybrid protein consists of yellow fluorescent protein (YFP) linked to two class I epitopes: one from OVA (OVA257–264) and one from Herpes simplex virus-1 glycoprotein B (gB498–505). The hybrid protein is referred to as YSS and the transgenic line RIP-YSS. YSS was expressed only in Pancreas.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15"]
[3447,"SOCS-1 (SOCS box) KO clone 311 (SOCS-1ΔSB)","C57BL/6-Socs1<tm2Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Normal","cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 2, Walter and Eliza Hall Institute of Medical Research","Socs1<tm2Wehi>","MGI:2177057","16",{"$nulls":15},"Yes",{"$nulls":12},"The SOCS box is a C-terminal domain shared with over 30 other proteins that links SOCS proteins to an E3 ubiquitin ligase activity and the proteasome. Mice have an increased responsiveness to IFN-\u0001 and slowly develop a fatal inflammatory disease.Homozygous \u0005\u0001\u0005 mice (SOCS-1ΔSB) were healthy at birth but died prematurely compared with \u0005\u0001\u0004 or wild-type animals. However,the onset of disease was prolonged compared with SOCS-1\u0001-/-\u0001 mice, and it most closely matched that seen previously for SOCS-1\u0001-/-/\u0001IFN-γ-\u0001-\u0004/\u0001 mice. In fact, the predominant disease states seen in \u0005\u0001\u0005SOCS-1ΔSB mice were remarkably similar in frequency and type to those of moribund SOCS-1\u0001-/- \u0001IFN-γ-\u0001\u0004/-\u0001 mice of the same age. Body weight was reduced and extensive inflammatory lesions were seen in skeletal and heart muscle, as well as in the cornea, sometimes with corneal ulceration. The infiltrating cells were predominantly lymphoid cells and macrophages, but the damage to muscle cells was often more severe than that seen in SOCS-1\u0001-/-\u0001IFN-γ-\u0001\u0004/-\u0001 mice. In addition, lymphoid foci were observed in the salivary glands, lungs, and kidneys of \u0005\u0001\u0005mice, and the ratio of granulocytes to mononuclear (lymphoid and erythroid) cells was elevated in the bone marrow. Like SOCS-1\u0001-/-\u0001 mice, \u0005\u0001\u0005 SOCS-1ΔSB mice showed atrophy and dispersion of pancreatic acinar tissue with lymphoid and macrophage infiltration of both the pancreas and dermis and atrophy or thinning of the thymic cortex. Although liver cells did not show fatty degeneration typical of SOCS-1\u0001-/-\u0001 mice, there were areas where the liver trabeculae were thin and widely separated, suggesting previous damage to hepatocytes. This phenotype suggested that SOCS-1\u0001\u0005/ΔSB acted as a partial loss of function mutant with significantly reduced capacity to inhibit responses to endogenous IFN-\u0001γ.Premature death: mice start dying around weaning age with 80% of mice dead by 80 days of age.Decreased body weight: weights drop as mice develop inflammatory disease.Absent spleen germinal center: 55% of mice have no germinal centers in the spleen.Thymus atrophy: is observed in 95% of mice.Increased inflammatory response: mice die from massive generalized inflammation that affects multiple organs.Myocarditis: 90% of mice have inflammation in heart muscle.Pancreas inflammation: is observed in 55% of mice.Salivary gland inflammation: is observed in 61% of mice.Intestinal inflammation: 15% of mice have GI inflammation.Increased incidence of corneal inflammation: is observed in 53% of mice with 16% of mice having inflammatory ulcers.Glomerulonephritis: is observed in 15% of mice th 5% of mice having polycystic disease and 5% necrosis.Liver inflammation: is observed in 35-40% of mice.Muscle inflammation: 90% of mice have inflammation in skeletal muscle.Skin inflammation: is observed in 50% of mice.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2008-07-17"]
[7267,"Tuara","CBA-Stat1<m2Anu>/AnuApb",null,"Recessive","signal transducer and activator of transcription 1","Stat1","Unknown",null,"MGI:103063",{"$nulls":3},"1",{"$nulls":28},"Unknown",null,"CBA","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-29","Cryopreserved sperm"]
[5623,"B6;129S5-Shc1tm1lex/Mmnc - incomplete ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7038,"zeta-C57BL/6 390","B6;129-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Poor","N/A",null,"het x het","No","2012-08-06","Cryopreserved sperm"]
[5544,"ENU18NIH:064a","C57BL/6JAnu-Dock2<m2Anu>/AnuApb","C57BL/6JAnu-Dock2<m2Anu>/AnuApb","Recessive","dedicator of cyto-kinesis 2","Dock2 ","Unknown","CED-5, Hch, MBC ","MGI:2149010","dedicator of cyto-kinesis 2; mutation 2, The Australian National University","Dock2<m2Anu>","MGI:5563490","11","ENSMUSG00000020143","ENSMUST00000093193","Dock2-001","4311","4380","T to A","ENSMUSE00000376674","43","1437","Tyrosine to STOP",{"$nulls":4},"CAGATCATAAACTTTTACAAGTCTAATTATGTGCAAAAGTTCCACTACTCCAGGCCTGTGC",{"$nulls":13},"Reduced numbers of mature B cells in peripheral blood; reduced numbers of T cells in peripheral blood with increased expression of CD44 protein on CD4<+> and CD8<+> cells.","Unknown","C57BL6/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-07-27","Cryopreserved sperm"]
[4706,"OT1xB6Ly5a","C57BL/6-Ptprc<a> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810",null,"Ptprc<a>",null,"1",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[5634,"Bat Gal",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6919,"FVBNJ-Momme D17","FVB/NJ-MommeD17 Tg(BA1-Gfp)3Ew/Apb",null,"Semi-dominant","Unknown","unknown",{"$nulls":6},"3",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of  enhancer region","36 copies",{"$nulls":9},"Lethal.Transgene expressed in red blood cells. Percentage of cells expressing GFP transgene is increased in Momme D17. ","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm"]
[7056,null,"B6;SWR-Clcn1<adr-mto>",null,"Recessive","chloride channel 1","Clcn1","Unknown","Clc1, Clc-1, nmf310, nmf355, NMF355, SMCC1","MGI:88417","chloride channel 1; myotonia","Clcn1<adr-mto>","MGI:1855953","6",{"$nulls":28},"Altered righting response: mice exhibit an arrested development of righting responseAbnormal voluntary movement: * mice exhibit stiffening of hindlimbs when supine with difficulty righting and stiffening of hindlimbs after rapid movement * abnormal phenotype is visible at 2 weeks of age and is progressive * at 2 weeks of age, mice exhibit stiff extensor postures of the limbs when gently dropped from a height of about 10 cm * when tested after 2 hours at 5 degrees Celsius, extensor posture is elicited more easily and its duration is increased by 50% * unlike in wild-type mice, scratching motion with hindlimb is not rapid * when place in an ice water bath mice exhibit a stiff extensor posture of the hindlimbs that is most prominent in the first minute and gradually subsides.Impaired limb coordination: mice are capable of swimming but alternate movements of the hindlimbs are not well coordinated.Abnormal gait: mice exhibit a slightly stiff gait and walk slower than wild-type mice.Muscle phenotype: mice do not display muscle fiber necrosis, grouped atrophy or inflammatory infiltratesIncreased skeletal muscle mass: by day 70, mice exhibit increased muscle bulk in the neck and shoulder girdle muscles compared to wild-type mice.Abnormal muscle physiology: percussion of muscles occasionally produces a sustained local contraction with sustained posturinghowever, muscle weakness is not observed.Abnormal muscle electrophysiology:  * mice exhibit myotonic discharges in limbs, abdominal, tongue, and eye muscles. * unlike in wild-type mice, myotonic discharges are detected from anesthetized mice whose muscles are percussed or stretched * unlike in wild-type mice, myotonic discharges continue for several minutes after amputation.Impaired muscle relaxation: mice exhibit myotoniaAxon degeneration: * by 225 days, mice exhibit degeneration of myelinated axons in the ventrolateral funiculus at all levels of the spinal cord. * however, nerve roots and mixed peripheral nerves are not affectedDecreased body weight: at 30 days mice weigh 10% less than wild-type mice and this difference increases to 40% in adulthood.Reduced fertility: mice are not reliable breeders.Kyphosis: * Background Sensitivity: mice usually develop mild dorsal kyphosis on a mixed background * at day 80, mice exhibit thoracic kyphosis at the T3 to T5 level.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-08-21"]
[3469,"Cystatin KO","B6.129-Cst3<tm1Karl>/Wehi",null,"Recessive","cystatin C","Cst3","Unknown","CysC, cystatin C","MGI:102519","targeted mutation 1, S Karlsson","Cst3<tm1Karl>","MGI:2182140","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[4974,"C151 CD9 DKO","C57BL/6-CD151<tm1Lka> CD9<Bcx>",null,"Recessive","Cd151 antigen","Cd151","Nil","PETA-3, SFA-1, Tspan24","MGI:1096360","targeted mutation 1, Leonie K Ashman","Cd151<tm1Lka>","MGI:3050539","7",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[4974,"C151 CD9 DKO","C57BL/6-CD151<tm1Lka> CD9<Bcx>",null,"Recessive","CD19 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<Bcx>","MGI:2180795","6"]
[5112,"las vegas ; ENU7B6:142","C57BL/6JSfdAnu-Tnfaip3<las>/AnuApb","C57BL/6JSfdAnu-Tnfaip3<las>/AnuApb","Recessive","tumor necrosis factor, alpha-induced protein 3","Tnfaip3","Unknown","A20, Tnfip3, zinc finger protein A20","MGI:1196377","tumor necrosis factor, alpha-induced protein 3; las vegas","Tnfaip3<las>","MGI:5563400","10","ENSMUSG00000019850","ENSMUST00000105527","Tnfaip3-002","974","1162","T to A","ENSMUSE00000098571","5","325","Isoleucine to Asparagine",{"$nulls":4},"AGGCTGGGACCACGGCACGACTCACCTGATCAACGCTGCAAAATTGGATGAAGCTAACTTA","Yes",{"$nulls":12},"Increased myeloid cells, lower % lymphocytes, increased % ofCD44<hi> expressing activated/memory T cells",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-10","Cryopreserved sperm"]
[4976,"ENU14:G1 ; Chokerre","ENU14China:014",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Embryonic lethal.E14 embryos are alive but look sick.Increase in primitive RBCDecrease in definitive RBC","Possible embryonic blood defect","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[6920,"FVBNJ-Momme D13","FVB/NJ-MommeD13 Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","Unknown","Unknown","Unknown",{"$nulls":5},"3",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter and enhancer region","36 copies",{"$nulls":9},"Lethal.Transgene expressed in red blood cells. Percentage of cells expressing GFP transgene is increased in Momme D13.","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm"]
[5637,"BDNF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7045,"Activin BK transgenic ; Inhba BKBK","B6.129S7-Inhba<tm2Zuk>/MarpApb",null,"Dominant","inhibin beta-A","Inhba",null,"activin","MGI:96570","inhibin beta-A; targeted mutation 2, Martin M Matzuk","Inhba<tm2Zuk>","MGI:2386671","13",{"$nulls":28},"Mice are viable, but manifest poor overall health at 7 weeks of age","Normal","C57BL/6 x 129S","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","Unknown",null,"Homozygous matings","No","2012-08-06","Cryopreserved sperm"]
[4978,"ENU11B6:108b","C57BL/6JAnu-Morc3<m1Anu>/AnuApb",null,"Recessive","microrchidia 3","Morc3","Unknown",null,"MGI:2136841",{"$nulls":3},"16","ENSMUSG00000039456","ENSMUST00000044068","Morc3-201",{"$nulls":7},"93860848","10",null,null,"TAAACTTGCCAGTCGAAGACATACAGTAAGTACTGAGCACTGAATTTTGACATACCGTTA","Yes",{"$nulls":12},"High expression of Ly6c in peripheral blood.Maturation defect in NK cells.","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[3473,"Socs3 - Socs Box del","C57BL/6-Socs3<tm1Robb>/Wehi",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Unknown","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 1, Lorraine Robb","Socs3<tm1Robb>","MGI:3835162","11",{"$nulls":15},"Yes",{"$nulls":12},"Normal.  Treatment of the mice with pharmacologic doses of G-CSF, which mimics emergency granulopoiesis and therapeutic use of G-CSF, revealed that SOCS3(Delta SB/Delta SB) mice were hyperresponsive to G-CSF. Compared with wild-type mice, SOCS3(Delta SB/Delta SB) mice developed a more florid arthritis when tested using an acute disease model. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[7626,null,"C57BL/6NCrlAnu-Zfp831<m1Anu>/Apb",null,"Recessive","zinc finger protein 831","Zfp831","Unknown","ENSMUSG00000050600, OTTMUSG00000017459","MGI:3641861","mutation 1, The Australian National University","Zfp831<m1Anu>",null,"2","ENSMUSG00000050600","ENSMUST00000059452","Zfp831-001","2752","2752","T to C","ENSMUSE00000357407","1","918","Tyrosine to Histidine",{"$nulls":4},"CTCGGTCAGGTGGCTTCTTTCCTCCCAAGTACCTCCTCAGGTTACCTCAGGGAGAGAACCC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-03-30","Cryopreserved sperm"]
[5455,"ENU13NIH:069b","C57BL/6JAnu-Pax5<m1Anu>/AnuApb","C57BL/6JAnu-Pax5<m1Anu>/AnuApb","Recessive","paired box gene 5","Pax5","Reduced","EBB-1, Pax-5","MGI:97489","paired box gene 5; mutation 1, The Australian National University","Pax5<m1Anu>","MGI:5563444","4","ENSMUSG00000014030","ENSMUST00000014174","Pax5-001","1053","1307","T to A","ENSMUSE00000660796","9","351","Tyrosine to STOP",{"$nulls":4},"TCTGGAAGTCCCTACAGCCACCCTCAGTATTCTTCCTACAATGATTCTTGGAGGTTCCCCA","Yes",{"$nulls":12},"No B cells.Small and sick looking.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm"]
[1542,null,"C57BL/6-Gzmb<tm1Ley> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb",null,"Recessive","granzyme B","Gzmb","Unknown","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06"]
[1542,null,"C57BL/6-Gzmb<tm1Ley> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Unknown","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","Unknown"]
[5558,"Caspase-1 KO","B6;129S2-Casp1<tm1Sesh>/AnuApb",null,"Recessive","caspase 1","Casp1","Nil","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544","caspase 1; targeted mutation 1, Tara Seshadri","Casp1<tm1Sesh>","MGI:1927822","9",{"$nulls":28},"Cellular phenotype: * macrophages and thymocytes from mutant mice retain their capacity to undergo apoptosis upon ex vivo stimulation by several different signals. * in response to ATP, mutant peritoneal macrophages undergo normal apoptosis relative to wild-type. * in response to dexamethasone, aging or gamma irradiation, thymocytes from young homozygotes undergo normal apoptosis relative to wild-type. * in response to LPS and D-galactosamine, homozygotes undergo normal TNF-induced hepatocyte apoptosis and show normal kinetics of death from hepatic failure relative to wild-type mice.Abnormal apoptosis: * mutant peripheral blood neutrophils display retarded constitutive apoptosis relative to wild-type neutrophils * mutant peripheral blood neutrophils show no LPS-mediated inhibition of apoptosis but remain susceptible to Fas-mediated apoptosis.Abnormal cell migration: in homozygotes lacking bioactive IL-1beta, IL-18 fails to induce the expected migration of epidermal Langerhans cells to draining lymph nodes following skin sensitization; as a result, immunostimulatory dendritic cells fail to accumulate in regional lymph nodes resulting in impaired initiation of cutaneous immune responses.Hematopoietic system phenotype: * homozygotes exhibit normal numbers of leukocytes, erythrocytes, and platelets in peripheral blood * freshly isolated mutant thymuses, spleens and lymph nodes contain a normal % of various T cell subsets and B cells relative to wild-type.Immune system phenotype: * in homozygotes, the % of B lymphocytes and the various T lymphocyte subsets found in mutant thymuses, spleens and lymph nodes appear unaffected relative to wild-type. * the size and lymphocyte counts in these lymphoid organs appear normal; myeolopoiesis remains unaffected.Decreased circulating interleukin-1 alpha level: LPS-treated mice show a 5-fold decrease in IL-1alpha levels in vivo.Decreased circulating interleukin-1 beta level: in vivo, homozygous males injected with a high dose of LPS display undetectable levels of mature IL-1beta in their plasma; females are slightly less affected.Decreased circulating interleukin-6 level: after injection with a high dose of LPS, homozygotes display a moderate reduction in IL-6 levels relative to wild-type mice.Decreased circulating tumor necrosis factor level: after injection with a high dose of LPS, homozygotes display a moderate reduction in TNF levels relative to wild-type mice.Abnormal macrophage physiology: ex vivo, thioglycollate-elicited peritoneal macrophages stimulated with LPS and ATP are defective in IL-1beta processing and release.Abnormal neutrophil physiology: * in addition to delayed apoptosis, mutant neutrophils show absence of LPS-stimulated IL-1beta production relative to wild-type. * in response to LPS-mediated acute lung injury, homozygotes show significantly increased total and percent neutrophil counts at 24 and 48 h; however, these numbers decline to wild-type levels by 72 h suggesting a delay in inflammatory neutrophil apoptosis.Decreased T cell apoptosis: in vitro, thymocytes from young homozygotes are resistant to Fas-induced apoptosis as measured by cell viability.Decreased interleukin-1 alpha secretion: surprisingly, homozygous males are also defective in IL-1alpha production, with macrophages releasing only 20-25% of wild-type IL-1alpha levels after stimulation with LPS and ATP ex vivo.Decreased interleukin-1 beta secretion: * homozygotes are impaired in their capacity to produce mature IL-1beta. * ex vivo, mutant peritoneal macrophages stimulated with LPS and ATP release less that 1% of wild-type IL-1beta levels; however, no decrease in pro-IL-1beta synthesis or release is detected. * in culture, mutant cortical neurons exhibit inhibition of hypoxia-mediated generation of mature IL-1beta.Abnormal inflammatory response: in response to LPS-mediated acute lung injury, homozygotes exhibit a prolonged neutrophilic inflammatory response and evidence of caspase-1-independent IL-1beta production in the lung.Decreased susceptibility to endotoxin shock: * strikingly, homozygotes are significantly resistant to the lethal effects of endotoxic shock after a high dose of LPS. * whereas all LPS-treated wild-type mice die within 30 hours after injection, all homozygotes survive for >45 hours, with only 30% of mutants dying during the next 5 days.Reproductive system phenotype: * homozygotes are fertile and produce a normal litter size relative to wild-type. * in addition, post-lactation involution of mammary glands remains grossly normal in mutant post-partum females.Decreased susceptibility to ischemic brain injury: * following right carotid artery ligation, newborn homozygotes (P9-P10) are resistant to moderate, but not to severe cerebral hypoxic-ischemic insults relative to wild-type mice. * under mild lesioning conditions (right carotid ligation plus 40 min 10% O2), newborn homozygotes show attenuated hypoxia-ischemia induced CCL2 (chemokine (C-C motif) ligand 2; also, MCP-1) expression at 8 h post-hypoxia relative to wild-type; no genotype differences in CCL2 production are observed in animals undergoing longer periods of hypoxia-ischemia (severe insult)>Decreased neuron apoptosis: * cultured cerebrocortical neurons from homozygotes are highly resistant to oxygen/glucose deprivation (OGD)-induced neuronal cell death, showing only 50% of lactate dehydrogenase release relative to wild-type neurons. * also, mutant neurons are highly resistant to Ripk2-mediated cell death; transfecting caspase-1 into mutant neurons restores sensitivity to Ripk2-induced apoptosis. * notably, cultured neurons show inhibition of OGD-mediated processing of various members of the caspase pathway, cleavage of Bid, and hypoxia-associated loss of mitochondrial transmembrane potential; in vivo, these findings are confirmed in a cerebral ischemia model.","Decreased interleukin-1 beta secretion: * heterozygotes are slightly impaired in their capacity to produce mature IL-1beta: ex vivo, heterozygous peritoneal macrophages stimulated with LPS and ATP release 50% of wild-type IL-1beta levels * no decrease in pro-IL-1beta synthesis or release is detected","C57BL/6 x 129S2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12","Cryopreserved sperm"]
[5559,"Nos2 KO","B6;129S7-Nos2<tm1Mrl>/AnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, John S Mudgett","Nos2<tm1Mrl>","MGI:2158791","11",{"$nulls":28},"Abnormal osteoclast morphology.Decreased osteoclast cell number: decreased by 25%Abnormal osteoclast differentiation: in vitro differentiation is markedly attenuated.Abnormal osteoclast physiology: resorption activity is considerably decreased.Increased bone mineral density: bone mineral density of the femur is elevated at both 4 and 9 weeks of age.Increased bone volume: total bone volume is increased.Increased compact bone mass: * increased cortical bone mass * trabecular bone thickness and connectivity unchanged from controls.Abnormal tooth hard tissue morphology: distance between cementoenamel junction and alveolar bone crest is greater than for controls from 6 weeks on (without any bacterial challenge).Abnormal response to infection: * do not respond to oral infection with Porphyromas gingivalis by bone loss * serum levels of specific IgG are comparable to controlsAbnormal involution of the mammary gland: * mammary gland regression after removal of pups is delayed * degree of regression at 72 hours is similar to controls * mammary gland development is normal at 10 days into lactation.Abnormal mammary gland physiology: increase in apoptosis levels of involuting mammary glands is delayed.Abnormal lactation: * elevated milk production * pups nourished by mutant mothers weigh more than pups nourished by control mothers.Increased circulating prolactin level: slightly elevated relative to controls.Abnormal cardiovascular system morphology.Abnormal uterine artery morphology: the large arteries of the uterus during pregnancy have thickened arterial walls and smaller lumina.Atherosclerotic lesions: found in about 35% of homozygotes.Abnormal heart ventricle morphology: total ventricle weights are greater than controls for males only.Abnormal cardiovascular system physiology.Abnormal blood circulation: islet blood flow under basal conditions is increased.Increased systemic arterial blood pressure.Increased mean systemic arterial blood pressure: * relative to controls * streptozotocin induced diabetes for 8 days results in a more modest increase in blood pressure than in similar controls.Increased systemic arterial systolic blood pressure: slightly increased at 3 months of age but not later.Increased infarction size: * area of infarction is greater than for controls in non-diabetic mice after ischemia-reperfusion * reperfusion injury is less in diabetic mice than in diabetic controls.Homeostasis/metabolism phenotype: * normal serum insulin. * obese mice on a high fat diet have normal insulin levels.Abnormal blood homeostasis.Increased circulating creatinine level: slightly elevated levels.Abnormal circulating estradiol level: the cyclic changes in estradiol level are abnormal in homozygous mutant females with the peak in estradiol concentration coming later than in 129/SvEv wild-type females.Increased circulating cholesterol level: levels 1.7 times normal at 9 months of age.Increased circulating triglyceride level: elevated plasma triglycerides.Abnormal circulating serum albumin level: slightly reduced at 3 months and tending to decline with age.Abnormal glucose homeostasis.Abnormal circulating glucose level: resistant to hyperglycemia induced by multiple low doses of streptozotocin.Improved glucose tolerance: * hyperglycemic in the first 30 minutes of a glucose tolerance test. * return to fasting glucose levels by 90 minutes when controls are still hyperglycemic.Increased insulin sensitivity.Abnormal hormone level.Decreased adiponectin level.Abnormal adrenocorticotropin level: plasma ACTH levels increase much more modestly after LPS treatment than for controls.Increased renin activity: plasma renin activity is increased.Decreased cerebral infarction size: * volume of infarction 96 hours after middle cerebral artery occlusion is 28% smaller than controls. * volume of infarction is similar to controls 24 hours after cerebral artery occlusion.Decreased susceptibility to kidney reperfusion injury: * protected from renal ischemia-reperfusion injury as indicated by lower serum creatine levels compared to controls * less tubular necrosis, tubular structure is almost normal * better survival rate at 24 hours after surgeriesAbnormal uterus morphology: the lining of the uterus during pregnancy shows a distinct lack of cellularity in homozygous female mutants compared to wild-type females.Abnormal uterine artery morphology: the large arteries of the uterus during pregnancy have thickened arterial walls and smaller lumina.Prolonged diestrus: diestrus length is increased in homozygous mutant females compared to 129/SvEv wild-type mice without an increase in total oestrus cycle length.Decreased litter size: by mid-gestation homozygous female mutants have significantly fewer viable embryos compared to wild-type females.Nervous system phenotype: chronic nerve constriction does not lead to breakdown of small myelinated fibers.Decreased cerebral infarction size: * volume of infarction 96 hours after middle cerebral artery occlusion is 28% smaller than controls * volume of infarction is similar to controls 24 hours after cerebral artery occlusion.Neuron degeneration: * moderate breakdown of larger caliber myelinated fibers 5 days after chronic nerve constriction at a time when controls have far fewer surviving fibers * fiber numbers are declining at 14 days but at a slower rate than for controls * degenerating myelinated fibers persist longer after nerve crush injuryAbnormal peripheral nervous system regeneration: * no regenerative myelinated sprouts at 21 days when they have begun to appear in controls * regenerating fibers are smaller in caliber after nerve crush injury * similar to controls by 6 weeks after nerve crush injury * nerve fiber regeneration is delayed and new fibers are smaller in diameter after nerve transection.Increased eating behavior: consume 1.6 times as much food as controls on a high fat diet.Abnormal motor capabilities/coordination/movement: motor deficiencies improve between 24 and 96 hours after cerebral artery occlusion unlike controls.Abnormal sensory capabilities/reflexes/nociception.Allodynia: tactile allodynia observed at 3 weeks when neuropathic pain is diminishing in controls.Abnormal response to tactile stimuli: tactile hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls.Abnormal thermal nociception: * thermal hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls * delayed thermal hypersensitivity observed at 3 weeks when neuropathic pain is diminishing in controls.Pancreas inflammation: * low level of islet inflammation as compared to controls when treated with streptozotocin. * islet size is normal.Increased length of allograft survival: * lower rejection rate of CBA/CaJ cardiac grafts * lower levels of apoptosis by all measures usedDecreased susceptibility to kidney reperfusion injury: * protected from renal ischemia-reperfusion injury as indicated by lower serum creatine levels compared to controls * less tubular necrosis, tubular structure is almost normal * better survival rate at 24 hours after surgeries.Increased body weight:body weight is greater than controls for males only.Increased growth rate: experience greater weight gain on a high fat diet.Abnormal digestion: do not respond to gastric luminal acid with as great an increase in gastric blood flow as do controlsvascular resistance is not diminished.Decreased digestive mucosecretion: * mucus accumulation rate about 25% of controls * firmly adherent layer of mucus is thinner than in controlsLiver fibrosis: * fibrotic changes in the livers of mice on a high fat diet particularly around degenerating hepatocytes and the central vein area * collagen fraction is higher than in controls when on a high fat diet.Allodynia: tactile allodynia observed at 3 weeks when neuropathic pain is diminishing in controls.Abnormal response to tactile stimuli: tactile hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls.Abnormal thermal nociception: * thermal hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls * delayed thermal hypersensitivity observed at 3 weeks when neuropathic pain is diminishing in controls.",null,"C57BL/6 x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12","Cryopreserved sperm"]
[5624,"B6.126Erbb4Tm2Fej/mmcd FloxedErbB4",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5244,"ENU18NIH 17a; ENU18NIH:017a","C57BL/6JAnu-Tnfsf13b<m1Anu>/AnuApb","C57BL/6JAnu-Tnfsf13b<m1Anu>/AnuApb","Recessive","tumor necrosis factor (ligand) superfamily, member 13b","Tnfsf13b","Unknown","BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4","MGI:1344376","tumor necrosis factor (ligand) superfamily, member 13b; mutation 1, Australian National University","Tnfsf13b<m1Anu>","MGI:5009047","8","ENSMUSG00000031497","ENSMUST00000033892","Tnfsf13b-201","81","81","T to A","ENSMUSE00000638270","1","27","Tyrosine to STOP",{"$nulls":4},"GAGAAAGGAGAAGATATGAAAGTGGGATATGATCCCATCACTCCGCAGAAGGAGGAGGGTG","Yes",{"$nulls":12},"T1 to T2 block in B cell development in spleen and increased % of immature B cells and decreased % of mature B cells in peripheral blood.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"1","Currently breeding at G4. Affected x affected, affected x unaffected, affected x B6","No","2010-10-15","Cryopreserved sperm"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,null,"MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 2, Matthias Ernst","Gpa33<tm1(Ctnnb1*)Ern>",null,"1",{"$nulls":28},"Unknown","Unknown","Mixed","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-01-24","Cryopreserved sperm"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","catenin (cadherin associated protein), beta 1","Ctnnb1",null,"beta catenin, beta-catenin, Bfc, Catnb","MGI:88276","catenin (cadherin associated protein), beta 1; targeted mutation 4, Walter Birchmeier","Ctnnb1<tm4Wbm>","MGI:2148594","9",{"$nulls":15},"No"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","adenomatosis polyposis coli","Apc","Reduced","CC1, Min","MGI:88039","adenomatosis polyposis coli; targeted mutation 1, Tetsuo Noda","Apc<tm1Tno>","MGI:1857966","18",{"$nulls":15},"Yes"]
[5109,"APN36","B6;129-Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>/Marp",null,"Recessive","Cysteine-rich secretory protien 1 C","Crisp1",null,"Aeg1, CRISP-1","MGI:102553","cysteine-rich secretory protein 1; gene trap CMHD-GT_255A4-3, Centre for Modeling Human Disease","Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>","MGI:3879688","17",{"$nulls":15},"Yes",{"$nulls":12},"N/A: Only bred to heterozygosity","Normal","C57BL/6J","No","Unknown","Yes","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-05-05","Cryopreserved sperm"]
[2362,null,"B6.AK-H2<k>/AnuApb","B6.AK-H2<k>/Apb","Dominant","histocompatibility-2, MHC","H2","Unknown","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17",{"$nulls":15},"Yes",{"$nulls":12},"The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Fas<lpr>/J",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-13","Cryopreserved sperm"]
[4849,"ENU6AT:HELxTCR:line014:Infertility:G4","ENU6AT:14:infertility",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Male infertility","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[4733,null,"B6;B10Br;129-Cblb<tm1Pngr> Tg(MLsHEL)Ccg ",null,"Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","Cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","soluble Hen Egg Lysozyme (HEL)","H-2K<b>","high",{"$nulls":9},"Defect in T cell signalling",null,"C57BL/6 x C57BL/10.Br x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","1","2",null,"No","2009-04-19","Cryopreserved sperm"]
[4975,"Booreana ; Ped11.28 ; ENU11B6:028","B10;B6-Myb<boo>/AnuApb","B10;B6-Myb<boo>/AnuApb","Recessive","myeloblastosis oncogene","Myb","Unknown","c-myb","MGI:97249","myeloblastosis oncogene; booreana","Myb<boo>","MGI:4867909","10","ENSMUSG00000019982","ENSMUST00000020156","Myb-201","923","1189","A to G","ENSMUSE00000644654","8","308","Glutamic acid to Glycine",{"$nulls":4},"GGAGTTGCTCCTGATGTCAACAGAGAACGAGCTGAAGGGACAGCAGGCATTACCAACACAG","Yes",{"$nulls":12},"E14.5 embryo:15x increase in platelet numbers2x increase in stem cells in foetal liver.Increase in primitive RBCDecrease in definitive RBCIncrease in haemopoietic  progenitor cellsPups are born and survive to adulthood. Adults display a 5x increase in platelet numbers","Normal","C57BL/6 x C57BL/10","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[4734,"Cbl-b KO:Hamlet:Charles","B6.129-Cblb<tm1Pngr> Tg(IghelMD4)4Ccg Tg(MLsHEL)Ccg/AnuApb",null,"Semi-dominant","Casitas B-lineage lymphoma b","Cblb","Nil","cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":11},"Defect in T cell signalling",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"10",null,"No","2009-04-19","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow"]
[7268,null,"SJL/J-Ank1<MRI95845>/MriApb","SJL/J-Ank1<MRI95845>","Dominant","ankyrin 1, erythroid","Ank1","Unknown","Ank-1, pale","MGI:88024","ankyrin 1, erythroid; MRI98545","Ank1<MRI98545>",null,"8","ENSMUSG00000031543","ENSMUST00000121802","Ank1-004","445","699","T to A","ENSMUSE00000995112","5","149","Tyrosine to Asparagine",{"$nulls":4},"CCCAGTCTCAGAAAGGCTTTACTCCCCTGTACATGGCTGCTCAGGAGAACCACTTGGAAGT",{"$nulls":13},"Pre and Perinatal mortality with Jaundice, enlarge spleen and fragmented red blood cells","Heterozygous mice display a microcytic anaemia with increase osmotic fragility, splenomegaly and survival advantage to Plasmodium chabaudi ","SJL/J","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-02-05","Cryopreserved sperm"]
[7627,"ENU28:G3","ANU:ENU28:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2014-03-31","Cryopreserved sperm"]
[3488,"Il-1R KO","C57BL/6-Il1r1<tm1>",null,"Recessive","interleukin 1 receptor, type I","Il1r1","Nil","CD121a, IL-1 receptor alpha chain, Il1r-1","MGI:96545",{"$nulls":3},"1",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mice are grossly normal but fail to respond to IL-1. Mildly immunocompromised",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5369,"NODSocs1/Lck","NOD/Lt-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Lck-cre)157Jxm",null,"Recessive","suppressor of cytokine signaling 1","socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research",null,"MGI:2656917","16",{"$nulls":15},"Yes","transgene insertion I57, Jamey Marth","lymphocyte protein tyrosine kinase (Lck)",{"$nulls":10},"Decreased B cell number: large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes.Abnormal T cell subpopulation ratio: * increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1. * increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged.Abnormal T cell differentiation: enhanced differentiation of thymocytes toward CD8+ T cells.Abnormal T cell activation: almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype.Abnormal CD4-positive T cell morphology: mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size.Increased CD4-positive T cell number: increase in CD4+ T cells in the blood.Abnormal CD8-positive T cell morphology: mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size.Increased CD8-positive T cell number:  * large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age. * increase in CD8+ T cells in the bloodAbnormal thymus medulla morphology: enlarged thymic medulla.Thymus hyperplasia: increase in thymus cellularity predominately due to an increase in CD8+ T cell population.Enlarged lymph nodes.Lymph node hyperplasia: lymph nodes contain 2-fold the number of cells in controls.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[5369,"NODSocs1/Lck","NOD/Lt-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Lck-cre)157Jxm",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","suppressor of cytokine signaling 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs1<tm1Wehi>","MGI:1934607","16",{"$nulls":15},"No"]
[3594,null,"C57BL/6-Tlr4 mutant",null,"Recessive","toll-like receptor 4","Tlr4","Unknown","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824",{"$nulls":3},"4",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06"]
[6242,"Bmf/473","B6.129-Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 2.1, Philippe Bouillet","Bcl2l11<tm2.1Boui>","MGI:4366751","2",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6242,"Bmf/473","B6.129-Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2"]
[5446,"ENU12NIH:071b N2","C57BL/6JAnu-Hmbs<m1Anu>/AnuApb","C57BL/6JAnu-Hmbs<m1Anu>/AnuApb","Dominant","hydroxymethylbilane synthase","Hmbs",null,"PBGD, porphobilinogen deaminase, Ups, Uros1","MGI:96112","hydroxymethylbilane synthase; mutation 1, The Australian National University","Hmbs<m1Anu>","MGI:5563463","9","ENSMUSG00000032126","ENSMUST00000077353","Hmbs-201","719","905","A to G","ENSMUSE00000216802","11","240","Aspartic acid to Glycine",{"$nulls":4},"TATCTTGGACCTAGTGAGTGTGTTGCACGATCCTGAAACTCTGCTTCGCTGCATTGCTGAA","Unknown",{"$nulls":12},"Autoflourescence during FACs runs","Autoflourescence during FACs runs","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","1","5","Affected x B6","No","2011-02-28","Cryopreserved sperm"]
[6245,"506","C57BL/6-Bcl2l11<tm3.1Boui>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 3.1, Philippe Bouillet","Bcl2l11<tm3.1Boui>","MGI:4366756","2",{"$nulls":28},"Increased leukocyte cell number:*Smaller increase in white blood cells numbers (<1.5 fold).Increased spleen weight:*Smaller increase in spleen weight.Immune system phenotype:*Normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7482,"Cxcr KO","C57BL/6-Cxcr3<tm1Wwh>/MarpAnuApb",null,"Recessive","chemokine (C-X-C motif) receptor 3","Cxcr3",null,"Cd183, Cmkar3, Cxcr3","MGI:1277207","chemokine (C-X-C motif) receptor 3; targeted mutation 1, Wayne W Hancock","Cxcr3<tm1Wwh>","MGI:2180682","X",{"$nulls":28},"Females:Decreased susceptibility to viral infection induced morbidity/mortality:\t• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive.Impaired macrophage chemotaxis:• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle.Abnormal cellular extravasation:\t• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis.• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells.• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia.Abnormal interferon level:• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days.Lung inflammation:\t• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury.• reduced numbers of CD8+ T cells after bleomycin injury.• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice.Decreased susceptibility to viral infection:• lack symptoms of infection at 7 days after infection with lymphocytic choriomeningitis virus.• less susceptibility to lymphocytic choriomeningitis virus.Increased length of allograft survival:• increased cardiac allograft survival.• grafts with fewer Cd4+ and Cd8+ T cells.Abnormal physiological neovascularization:\t• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls.• poor recovery of blood flow after schema.Abnormal interferon level:\t• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-14","Cryopreserved sperm"]
[4745,"Lyn:Hamlet","B6.129-Lyn<tm1Ard> Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Unknown","Hck-2","MGI:96892","targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"15",null,"No","2009-04-27","Cryopreserved sperm"]
[5626,"B6.129 S2.Oprm1 tm1KGf/J (mu-opoid)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6621,"ENU19WT 029a:G2","ANU:ENU19WT:029:a:G2",null,"Semi-dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-14","Cryopreserved sperm"]
[7058,"Crisp1 KO","B6;129-Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>/Marp",null,"Recessive","Cysteine-rich secretory protien 1 C","Crisp1",null,"Aeg1, CRISP-1","MGI:102553","cysteine-rich secretory protein 1; gene trap CMHD-GT_255A4-3, Centre for Modeling Human Disease","Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>","MGI:3879688","17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6J","No","Unknown","Yes","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-08-22","Cryopreserved sperm"]
[5641,"Box 1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5561,"WT control","B6;129/Sv",null,"Dominant",{"$nulls":37},"WT control for researchers experiments",null,"C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-12"]
[5370,"377SCID","NOD/Lt.Cg-Tg(Ins2-Cd80)377-6Wehi Prkdc<scid>",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes","CD80 antigen","rat insulin promoter","islet cells",{"$nulls":9},"Introduction of the CD80 transgene into the nonobese diabetic (NOD) genetic background resulted in early spontaneous autoimmunity, but splenocytes from the diabetic animals could only transfer diabetes to NOD<scid> recipients that expressed CD80 on their β cells. Islet destruction required continuousCD80 expression by target β cells.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[5371,"B6IL-1R","B6.Cg-Il1r1<tm1Rom>/JWehi",null,"Recessive","interleukin 1 receptor, type I","Il1r1","Nil","CD121a, IL-1 receptor alpha chain, IL-iR, Il1r-1","MGI:96545","interleukin 1 receptor, type I; targeted mutation 1, Mark A Labow","Il1r1<tm1Roml>","MGI:1857441","1",{"$nulls":15},"No",{"$nulls":15},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[5555,"IL-1RA KO","B6;129S-Il1rn<tm1Dih>/Anu",null,"Recessive","interleukin 1 receptor antagonist","Il1rn","Nil","IL-1ra","MGI:96547","interleukin 1 receptor antagonist; targeted mutation 1, David Hirsh","Il1rn<tm1Dih>","MGI:2157398","2",{"$nulls":28},"Decreased body weight: lower body weight apparent by 6 weeks of age.Decreased circulating interleukin-1 level: decreased serum levels of IL1 after endotoxin exposure.Increased circulating interleukin-6 level: increased basal serum IL6 levels.Abnormal circulating serum amyloid protein level: increased basal serum amyloid P levels.Increased acute inflammation: increased hepatic acute phase protein response to subcutaneous turpentine administration, increased mortality to turpentine abscess induction: 50% of mice died by day 5.Increased susceptibility to endotoxin shock: more susceptible to lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to bacterial infection: less susceptible to experimental Listeria monocytogenes infection.Reduced fertility: decreased number of offspring.Decreased circulating cholesterol level: 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks.","Increased susceptibility to endotoxin shock: more susceptible to lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to bacterial infection: less susceptible to experimental Listeria monocytogenes infection, heterozygotes display an intermediate phenotype.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival to ANU",null,"No","2011-08-12"]
[6623,"TG2.129T2","129-Tgm2<tm1.1Rmgr>/Apb",null,"Recessive","transglutaminase 2, C polypeptide","Tgm2","Nil","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 1.1, Robert M Graham","Tgm2<tm1.1Rmgr>","MGI:3527996","2",{"$nulls":15},"No",{"$nulls":12},"Abnormal cell adhesion: fewer homozygous fibroblasts (20% versus 79% of wild-type) adhered to poly-L-coated or fibronectin coated slidesAbnormal T cell physiology: 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired.",null,"129T2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-18","Cryopreserved sperm"]
[823,"ACTFLPtg","B6.Cg-Tg(ACTFLPe)9205Dym/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 9205, Susan Dymecki","ACTB, actin, beta, human","The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively",{"$nulls":9},"The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively. ","Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[119,"c-cbl KO","B6.129S1-Cbl<tm1Ddlb>/WlanAnuApb","B6.129S1-Cbl<tm1Ddlb>/WlanAnuApb","Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","11",null,null,"No","2006-02-06","Cryopreserved sperm"]
[3530,null,"Balb/c-Rag1",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848",{"$nulls":3},"1",{"$nulls":15},"Yes",{"$nulls":12},"Immuncompromised",null,"Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29"]
[2039,"STAT1 KO","B6;129-Stat1<tm1Rds>/Apb","B6;129-Stat1<tm1Rds>/Apb","Recessive","signal transducer and activator of transcription 1","Stat1","Nil",null,"MGI:103063","targeted mutation 1, Robert D Schreiber","Stat1<tm1Rds>","MGI:1861949","1",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Increased sensitivity to microbial pathogens and viruses due to impaired responsiveness to interferons.Increased Bone mass.Increased osteoclast cell number.","No phenotype reported.","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"homozygous x homozygous","Yes","2007-09-21","Cryopreserved sperm"]
[1861,"Sox2-Cre","CD1-Tg(Sox2-cre)1Amc",null,"Recessive",{"$nulls":25},"transgene insertion 1, Andrew P McMahon","SRY-box containing gene 2 (Sox2)",{"$nulls":10},"Cre expression in epiblast.",null,"CD1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[6876,"BRINP3 Targeted","C57BL/6-Fam5c<tm1>/Marp",null,"Recessive","family with sequence similarity 5, member C","Fam5c",null,"DBC3, B830045N13Rik","MGI:2443035",{"$nulls":3},"1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-23","Cryopreserved sperm"]
[7062,"Momme D11","FVB/NJ-MommeD11 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D11","MommeD11","Unknown",{"$nulls":5},"8",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~E14.5 dpc)","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD11<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm"]
[5628,"B6.129P2-Lgr5",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5948,"NOD.CD45.2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[840,"CD40 KO","B6.129P2-Cd40<tm1kik>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.Immune system phenotype: normal numbers and ratios of T and B cells.Decreased neutrophil cell number:* in non-SPF facilities compared to wild-type controlsAbsent spleen germinal center: failed to form.Abnormal humoral immune response.Decreased immunoglobulin level:* reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin.* response to thymus-independent (TI) antigens was in tact.Decreased susceptibility to type II hypersensitivity reaction:*in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis* deposition of IgG and complement in glomeruli not observed* glomeruli almost normal* fibrin deposition in glomeruli not observed* failure to induce proteinuria",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2007-05-23"]
[5161,"ENU14 NIH 17b","ENU14NIH:017b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Shaky gait, and uncoordinated","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Unknown","Yes","Yes","Poor",null,"1",null,"No","2010-06-28","Cryopreserved sperm"]
[7064,"Momme D21","FVB/NJ-MommeD21 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D21","MommeD21",{"$nulls":6},"16",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD21<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm"]
[5474,"Rosa 26; MF-05","C57BL/6-Gt(ROSA)26Sor<tm1Sor>/Apb",null,"Recessive",{"$nulls":25},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-04-06","Cryopreserved sperm"]
[3405,"C57BL/6. ACT-mOVA - H2b","C57bL/6-H2-K<bm1> Tg(CAG-OVA)916Jen/Wehi",null,"Dominant",null,null,"Normal",null,null,"histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17",{"$nulls":15},"Yes","transgene insertion 916, Marc K Jenkins","chicken β-actin",{"$nulls":10},"Ubiquitously express membrane bound chicken ovalbumin under the control of chicken β-actin promoter. Breed less well than hets",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13"]
[5630,"B6.129S6-Erap1tm1Luc/J (ERAP) ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5629,"B6.129S2.Oprm1tm1Kff/J ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3539,null,"C57BL/6-Mixl1-lacZ KO",null,"Recessive","Mix1 homeobox-like 1 (Xenopus laevis)","Mixl1","Normal","Mm1, Mml","MGI:1351322","Mix1 homeobox-like 1 (Xenopus laevis); targeted mutation 1, Lorraine Robb ","Mixl1<tm1Robb>","MGI:2387828","1",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal- embryonic lethality during organogenesis - homozygous embryos are present in normal numbers at E7.5, but are absent after E10.5. Embryos with severely disorganized head folds are only rarely recovered at E9-9.5; such embryos have failed to turn or form a heart tube. At E9.5, axial tissue mass present at E8.5 has grown and developed into huge mass of tail bud-like tissue protruding dorsally from caudal region of embryo, giving impression that axis is bifurcated.  Abnormal embryogenesis/ development - at E8.5, embryos adopt a flattened disc morphology instead of a lordotic shape. Abnormal primitive streak morphology - by E7, mutants display a thickened primitive streakan excess of mesoderm-like cells accumulates in anterior streak and in region lateral to streak at E7. Abnormal Henson's node morphology - homozygotes lack a recognizable node at E7Abnormal rostral-caudal axis patterning - at E8.5, AP axis is markedly shortenedAbnormal axial mesoderm.  Abnormal embryonic tissue morphology - definitive endoderm is specified, but gut morphogenesis is defective in mutants. Abnormal notochord morphology - notochord is replaced by a thick axial mass of flattened neuroectoderm overlying a condensed core of mesodermal tissues. At E9.5, mutants have a poorly organized structure resembling the notochordal plate and a notochord-like structure that ends caudally either in an ectopic protrusion or in a bulbous mass. Abnormal somite development - from two to five somite pairs form in the paraxial mesoderm flanking a thick axial mass of flattened neuroectoderm overlying a condensed core of mesodermal tissues. Enlarged allantois - compared to wild type, allantois is disproportionately large.Abnormal neural fold formation (J:77443)at E8.5, neural folds are small and disorganized with little head mesenchyme found beneath the head folds. Abnormal neural fold elevation formation - in early-neural plate stage (E7.75), elevation of neural folds is retarded and a shallow anterior intestinal portal developscardiovascular system.  Abnormal heart tube morphology - heart tube is absent at E8.25. Abnormal foregut morphology - foregut invagination is rudimentary and no hindgut portal is formed by E8.25.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29"]
[4996,"4AT22","ENU4AT:22",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Anti-nuclear antibodies, high.Both young and older mice.","Normal","C57BL/6 x B10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[4995,"4AT36 ; jellybean","ENU4AT:036",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[4898,"129/Sv","129/Sv Wildtype",null,"Dominant",{"$nulls":37},"Normal.",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-10-09","Cryopreserved sperm"]
[6887,"APN178","C57Bl/6N-Gpx3<tm1a(KOMP)Wtsi>/MarpApb",null,"Recessive","glutathione peroxidase 3","Gpx3 ","Unknown","EGPx, extracellular GPx, GPx, plasma GPx ","MGI:105102","glutathione peroxidase 3; targeted mutation 1a, Wellcome Trust Sanger Institute ","Gpx3<tm1a(KOMP)Wtsi> ","MGI:4841147","11",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-03","Cryopreserved sperm"]
[170,"RetTGM","C57BL/6-Ret<tm1Jmi>",null,"Recessive","ret proto-oncogene","Ret","Nil","RET51, RET9","MGI:97902","targeted mutation 1, Jeffrey Milbrandt","Ret<tm1Jmi>","MGI:2449909","6",{"$nulls":15},"Yes",{"$nulls":12},"All cells expressing Ret express GFP in both the nucleus and cytoplasm. Homozygous null mice die at birth, probably from gut motility defects.","None reported","C57BL/6","No","No","No","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[6924,"ENU20:B6:28:b","ANU:ENU20:028:b",null,"Recessive","Unknown","unknown",{"$nulls":6},"Unknown",{"$nulls":29},"We are currently looking for a prostate phenotype.","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-06-28","Cryopreserved sperm"]
[5159,"NODEYFP","NOD.129-Gt(ROSA)26Sor<tm1(EYFP)Cos>/MarpApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":28},"Normal NOD mouse: reporter mouse for cre expression","Normal NOD mouse: reporter mouse for cre expression","NOD","No","Unknown","Yes","No","Unknown","Yes","No","Unknown","10+",null,null,"No","2010-06-28","Cryopreserved sperm"]
[6615,"PIPP Floxed","C57BL/6J-Inpp5j<tm1>/Marp",null,"Dominant","inositol polyphosphate 5-phosphatase J","Inpp5j","Unknown","Pib5pa, Pipp","MGI:2158663",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-12","Cryopreserved sperm"]
[6626,"MH2","FVB-Tg(TetO-Myh6*R403Q)1Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion 1, Robert Graham","tetO-CMV",{"$nulls":10},"Normal",null,"FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[7271,"APN182","C57BL/6N<Atm1Brd> Tnfsf13<tm1(KOMP)Wtsi>/Marp",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 13","Tnfsf13 ","Unknown","2310026N09Rik, APRIL, TALL2, TRDL1","MGI:1916833","tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Wellcome Trust Sanger Institute/Monash Animal Research Platform","Tnfsf13<tm1(KOMP)Wtsi>/Marp ","MGI:4419527","11",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-02-06","Cryopreserved sperm"]
[6641,"NOD.HinsATriple427","NOD.Cg-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427 Tg(Ins2-INS1)/Apb",null,"Dominant","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No","human leukocyte antigen class II",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-11-03","Cryopreserved sperm"]
[{"$nulls":30},"human leukocyte antigen class II"]
[{"$nulls":30},"human leukocyte antigen class II"]
[7299,"RBC16","C;B6-Cpox<Rbc16>/MarpApb",null,"Dominant","coproporphyrinogen oxidase","Cpox","Unknown","Cpo","MGI:104841",{"$nulls":3},"16",{"$nulls":28},"Embryonic lethal at E10.5","Low mean cell volume and mean cell hemoglobin and anemia","BALB/C","No","No","Yes","No","No","Yes","No","Good",null,null,"Heterozygous intercrosses","No","2013-03-26","Cryopreserved sperm"]
[5376,"HinsA Triple 427","C57BL/6-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427 Tg(Ins2-INS1)/Apb",null,"Dominant",{"$nulls":39},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-22","Cryopreserved sperm"]
[6925,"APN151","C57BL/6N-A<tm1Brd> Ptafr<tm1a(KOMP)Wtsi>/MarpApb",null,"Recessive","platelet-activating factor receptor","Ptafr","Unknown","PAFR, PAF receptor","MGI:106066","platelet-activating factor receptor; targeted mutation 1a, Wellcome Trust Sanger Institute ","Ptafr<tm1a(KOMP)Wtsi> ","MGI:4460278","4",{"$nulls":28},"Unknown","Normal","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-06-28","Cryopreserved sperm"]
[6627,"tTA","FVB.Cg-(myh6-tTA)6Smbf",null,"Dominant",{"$nulls":25},"transgene insertion 6, Section of Myocardial Biology - Fishman Lab","rat Myh6 and tetracycline transactivator sequence","cardiac tissue",{"$nulls":9},"Normal",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[7629,null,"B6/Mrit-131297","B6/Mrit-131297","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a growth delay for a week.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7066,"Momme D30","FVB/NJ-MommeD30 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D30","MommeD30",{"$nulls":6},"17",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD30<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm"]
[5652,"C57BL/6J hPG",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3555,null,"B6.C-Lmo4<tm1Sho>/Wehi",null,"Recessive","LIM domain only 4","Lmo4","Normal","A730077C12Rik, Crp3, Etohi4","MGI:109360","LIM domain only 4; targeted mutation 1, Stuart Orkin ","Lmo4<tm1Sho>","MGI:3035911","3",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6 x BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31"]
[6628,"A1A1tg","FVB-Tg(Myh6-Adra1a)A1A1Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion A1A1, Robert M Graham"," rat alpha-myosin heavy chain promoter","heart",{"$nulls":9},"Premature death:  * 83 of 171 die at a mean age of 155 days with a cumulative mortality of 48.5%. * premature death is sudden with no signs of heart failureCardiac fibrosis: develop progressive cardiac fibrosis with age, beginning at 2 months of age.Increased cardiac muscle contractility: exhibit enhanced contractility as evidenced by a 33% increase in fractional shortening, a 72% decrease in left ventricle (LV) internal dimension at end-systole, an 8% decrease in LV internal dimension at end-diastole, an 80% increase in maximum dP/dt, a 76% increase in dP/dt max/LVPinst, and a 104% increase in dP/dt max:dP/dt min.Increased ventricle muscle contractility: * 1-month old mutants exhibit enhanced left ventricle contractility with no change or a slight decrease in LV relaxation, resulting in a marked increase in the ratio of dP/dt max to dP/dt min. * cardiac contractility declines with age and diastolic function is reduced, although older mutants still show an increase in dP/dt max compared to wild-type.Abnormal cardiac muscle relaxation: time constant of isovolumetric relaxation is prolonged by 40%, indicating impaired relaxation.Decreased left ventricle diastolic pressure: LV end-diastolic pressure is significantly lower.Increased heart rate: * heart rate is 16% higher than in controls, however no alterations in systolic or diastolic aortic pressure is seen. * baseline heart rate is increased by 17-27% at 2 months of age, however this difference is no longer seen in older mutants.Decreased QRS amplitude: death is preceded by a marked and progressive decrease in the QRS amplitude.",null,"FVB/N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[340,"TgAPP751 (Tg72-3 line)","B6.SJL-Tg(APP751)72-3Aust ",null,"Dominant",{"$nulls":25},"amyloid beta (A4) precursor protein","moPrP, hamster prion protein promotor",{"$nulls":10},"Transgene primarily expressed in brain.No overt phenotype, normal growth and breeding.","No overt phenotype, normal growth and breeding.","C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Strain is homozygous for transgene. Positive male breeds with female.","Yes","2006-09-22","Cryopreserved sperm"]
[6629,"A1A2tg","FVB-Tg(Myh6-Adra1a)A1A2Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion A1A2, Robert M Graham"," rat alpha-myosin heavy chain promoter","heart",{"$nulls":9},"Premature death:  * 83 of 171 die at a mean age of 155 days with a cumulative mortality of 48.5%. * premature death is sudden with no signs of heart failureCardiac fibrosis: develop progressive cardiac fibrosis with age, beginning at 2 months of age.Increased cardiac muscle contractility: exhibit enhanced contractility as evidenced by a 33% increase in fractional shortening, a 72% decrease in left ventricle (LV) internal dimension at end-systole, an 8% decrease in LV internal dimension at end-diastole, an 80% increase in maximum dP/dt, a 76% increase in dP/dt max/LVPinst, and a 104% increase in dP/dt max:dP/dt min.Increased ventricle muscle contractility: * 1-month old mutants exhibit enhanced left ventricle contractility with no change or a slight decrease in LV relaxation, resulting in a marked increase in the ratio of dP/dt max to dP/dt min. * cardiac contractility declines with age and diastolic function is reduced, although older mutants still show an increase in dP/dt max compared to wild-type.Abnormal cardiac muscle relaxation: time constant of isovolumetric relaxation is prolonged by 40%, indicating impaired relaxation.Decreased left ventricle diastolic pressure: LV end-diastolic pressure is significantly lower.Increased heart rate: * heart rate is 16% higher than in controls, however no alterations in systolic or diastolic aortic pressure is seen. * baseline heart rate is increased by 17-27% at 2 months of age, however this difference is no longer seen in older mutants.Decreased QRS amplitude: death is preceded by a marked and progressive decrease in the QRS amplitude.",null,"FVB/N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[6921,"Recql4 fl/fl","C57BL/6-Recql4<tm2272Arte>/Apb",null,"Dominant","RecQ protein-like 4","Recql4","Nil",null,"MGI:1931028","Recql4 fl/fl",null,null,"15",{"$nulls":28},"homozygous fl/fl mice are normal, viable and fertile",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","generated on pure C57BL/6 so not backcrossed. Only maintained on C57",null,"fl/+ to fl/+","No","2012-06-27","Cryopreserved sperm"]
[336,"Zfp145<tm1>","129-Zbtb16<tm1Ppp>",null,"Recessive","zinc finger and BTB domain containing 16","Zbtb16","Nil","Green's luxoid, PLZF, Zfp145","MGI:103222","targeted mutation 1, Pier Paolo Pandolfi","Zbtb16<tm1Ppp>","MGI:2182708","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2006-05-05"]
[6250,"UBC-GFP","C57BL/6-Tg(UBC-GFP)30Scha/J",null,"Dominant",{"$nulls":25},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5655,"C5aR KO ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7665,"Gsto KO","B6;129/Sv-Gsto1<tm1Tac>/TacAnuApb",null,"Recessive","glutathione S-transferase omega 1","Gsto1",null,"GSTX, p28","MGI:1342273",{"$nulls":3},"19",{"$nulls":28},"Unknown",null,"C57BL/6NTac","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-04-15","Cryopreserved sperm"]
[7522,"TgC100.WT","B6.DBA-Tg(ACTB-APP)1Colm/ArcApb","B6.DBA-Tg(ACTB-APP)1Colm/Arc","Dominant",{"$nulls":25},"transgene insertion 1, Colin L Masters","human beta actin","High",{"$nulls":9},"Abnormal emotion/affect behaviour:• old mice exhibit decreased immobility during a forced swim test compared with wild-type mice.Behavioral despair:• young mice exhibit increased immobility during a forced swim test compared with wild-type mice.Decreased startle reflex:• in young mice but not old miceHyperactivity:• in young, but not old, mice exhibit increased activity in an open field test and entries in a Y-maze compared with wild-type mice• at 9 and 22 months, mice exhibit slight hyperactivity compared with wild-type mice",null,"C57BL/6 x DBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"26","sib x sib","No","2013-11-29","Embryo"]
[7630,null,"SJL/ASAM<MRI53426>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[3485,null,"C57BL/6-Cd8a<tm1Mak>",null,"Recessive","CD8 antigen, alpha chain","Cd8a","Unknown","Ly-2, Ly-35, Ly-B, Lyt-2","MGI:88346","targeted mutation 1, Tak Mak","Cd8a<tm1Mak>","MGI:1857149","6",{"$nulls":15},"Yes",{"$nulls":12},"Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens. CD8-positive T cells are absent resulting in an increased susceptibility to viral infection. There is also demyelination of the nerve cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5122,"Sox10LacZ","C57BL/6-Sox10<tm1Weg>",null,"Dominant","SRY-box containing gene 10","Sox10","Nil","Sox21","MGI:98358","SRY-box containing gene 10; targeted mutation 1, Michael Wegner","Sox10<tm1Weg>","MGI:2151173","15",{"$nulls":28},"lacZ is expressed by all Sox10-expressing cells","lacZ is expressed by all Sox10-expressing cells","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-05-12"]
[4508,null,"ENU7B6:071",null,"Recessive","lymphotoxin B","Ltb",null,"LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3","MGI:104796",{"$nulls":3},"17","ENSMUSG00000024399","ENSMUST00000025262","Ltb-001","623","706","G to A","ENSMUSE00000930622","3","208","Arginine to Lysine",{"$nulls":4},"CTATTACCTCTACTGCCACGTCGGGTACAGGGGCAGGACGCCCCCTGCCGGCCGAAGCCGT","Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[7631,null,"SJL/ASAM<MRI26140>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[5657,"C5L2 x C5aR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5658,"C8 (C8 Brca1 Co/Co)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2774,"BALB/c.hK14-FLII 36","BALB/c-Tg(hK14-FLII)36/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT BALB/c","No","2008-02-16","Cryopreserved sperm"]
[5120,"endothelin-3+/-","B6.129-Edn3<tm1Ywa>/J",null,"Recessive","endothelin 3","Edn3","Nil","114-CH19, 114CH19, tmgc48","MGI:95285","endothelin 3; targeted mutation 1, Masashi Yanagisawa","Edn3<tm1Ywa>","MGI:1857160","2",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality: mice have a mean life span of 21 days, with a range of 4-65 days.Variable body spotting: * extensive white spotting (70 - 80% of body surface) * white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs.Abnormal colon morphology: distal portion of colon narrow and spastic; proximal portion of colon distended.Aganglionic megacolon: absence of myenteric ganglion neurons in distal, spastic segment of colon.Absent enteric neurons: absence of myenteric ganglion neurons in distal, spastic segment of colon.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10",null,null,"No","2010-05-12"]
[7527,"NOD.B6Idd11A","NOD.B6-Idd11<C57BL/6>/ArcApb",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes",{"$nulls":8},"insulin dependent diabetes susceptibility 11; C57BL/6","Idd11<C57BL/6>",null,"4",null,null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo"]
[1758,"Apaf-1 knockout","C57BL/6-Apaf1<Gt(IRESBetageo)XIX18Pgr>",null,"Recessive","apoptotic peptidase activating factor 1","Apaf1","Nil","6230400I06Rik, Apaf1l","MGI:1306796","apoptotic peptidase activating factor 1; gene trap XIX18, Peter Gruss","Apaf1<Gt(IRESBetageo)XIX18Pgr>","MGI:1857868","10",{"$nulls":15},"No",{"$nulls":12},"Lethality throughout fetal growth and development: embryonic defects apparent by E12.5, die by E17.       Decreased apoptosis:* induction of apoptosis in mutant embryonic fibroblasts is similar to controls, but mutant fibroblasts show reduced cell death after prolonged treatment with apoptotic stimuli (anti-Fas antibody, C6-ceramide, and staurosporin).* tissues that normally exhibit apoptosis in developmental stages instead exhibit hyperplasia and/or overgrowth.Abnormal craniofacial bone morphology.Absent ethmoidal bone.Impaired ossification of basisphenoid bone.Absent neurocranium: absence of skull vault.Absent vomer bone.Cleft palate: late and imperfect palatial fusion occursMidline facial cleft.Nervous system phenotype: at E13-14 and E18, numbers of spinal motoneurons and dorsal root ganglion neurons are not different from wild-type.Abnormal brain morphology: brain hyperplasia presumably due to lack of apoptosis in the mantle layer of the developing diencephalon, midbrain, cerebellum and ventricular layer of the choroid plexus of the fourth ventricle; an excess of differentiating neurons is observed in these locations.Abnormal brain development.Abnormal embryonic neuroepithelial layer differentiation: overgrowth resulting in abnormal folding and generation of a mantle layer.Abnormal cortical marginal zone morphology.Abnormal folding of telencephalic vesicles: may be due to intense overgrowth (hyperplasia) of diencephalon and midbrain.Small telencephalic vesicles: may be due to intense overgrowth (hyperplasia) of diencephalon and midbrain.Exencephaly.Hydroencephaly: results from obliteration of the lumen of the neural tube.Choroid plexus hyperplasia: hyperplasia of the choroid plexus of the fourth ventricle is seen.Hypothalamus hyperplasia: abnormal overgrowth of ventral side of hypothalamus through the base of the skull.Diencephalon hyperplasia.Midbrain hyperplasia.Abnormal neuron morphology: at E14 and E18, motoneurons and DRG neurons exhibit degenerative-like changes not seen in wild-type.Abnormal neuron physiology: at E14, developing neurons undergo atypical programmed cell death (PCD) in contrast to type 1 (apoptotic-like) mechanism exhibited in wild-type neurons; apoptotic-like degeneration markers (such as TUNEL labeling) are not observed in dying mutant neurons.Abnormal lens polarity.Small lens.Persistence of hyaloid capillary system: eye vascular endothelial cells obliterate the optic cup at E14.5.Retina hyperplasia:* by E12.5, the retina is noticeably thicker* by E14.5, the hyperplastic retina fills the optic cup and is folded.Interdigital webbing: interdigital webbing in limb buds with reduced apoptosis.Abnormal craniofacial bone morphology.Absent ethmoidal bone.Impaired ossification of basisphenoid bone.Absent neurocranium: absence of skull vault.Absent vomer bone.Cleft palate: late and imperfect palatial fusion occursAbnormal embryonic neuroepithelial layer differentiation: overgrowth resulting in abnormal folding and generation of a mantle layer.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[6651,"RBC13","C;B6-Hbb-b1<Rbc13>/WehiMarpApb",null,"Dominant","Hbb-b1  hemoglobin, beta adult major chain","Hbb-b1","Reduced","beta maj, beta major globin, beta1, beta-s","MGI:96021","hemoglobin, beta adult major chain; red blood cell mutant 13","Hbb-b1<Rbc13>","MGI:5460881","7",{"$nulls":28},"Lethal at E18.5 or just after (not present at birth). Embryos are normal until E16.5 where they manifest progressive pallor and reduced fetal liver cellularity.","Microcytic, hypochromic anemia with severe reticulocytosis. Compensatory erythropoiesis with splenic extramedullary hematopoiesis due to red cell destruction. ","C57BL/6 and BALB/c","No","No","Yes","No","No","Yes","No","Excellent",null,null,"Heterozygote intercross and background strain wild type to heterozygote","No","2011-11-28","Cryopreserved sperm"]
[7669,"ENU31:G1","ANU:ENU31:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-05-02","Cryopreserved sperm"]
[5661,"Cardiac Cre ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[1837,"B-CK","B6.129-Ckb<tm1Bew>/Wehi",null,"Recessive","creatine kinase, brain","Ckb","Nil","B-CK, Ck-3","MGI:88407","targeted mutation 1, Be Wieringa","Ckb<tm1Bew>","MGI:3042843","12",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mice have abnormal hippocampal morphology with enlarged mossy fiber field size and display resistance to pharmacologically induced seizures, reduced habituation and spatial learning impairments and are slightly smaller than wildtype littermates.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08"]
[1848,null,"B6.C3-Tg(APPswe,PSEN1dE9)85Dbo",null,"Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","Each transgene controlled by mouse prion promoter.",{"$nulls":11},"Cerebral amyloid angiopathy:* exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months* amyloid deposition is observed in leptomeningeal vasculature.Amyloid beta deposits:* sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks.* deposits are more extensive in females.* level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age.* senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age.* plaques are restricted to cortex and hippocampus at time points up to 12 months of age.* plaques increase in number and size over time.* exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months.* insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control.* total amyloid beta levels are increased by 3.6 fold in sucrose fed mice.* amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice.Increased drinking behavior: mice fed sucrose water exhibited increased water consumption.Abnormal spatial learning* transgenic mice fed sucrose water failed to learn Morris water maze test after 5 days of training.* water-fed transgenic mice retained some learning ability over 5 day test period, but did not perform as well in the water maze test as non-transgenic controls.Increased circulating insulin level: fasting plasma insulin levels are increased 3 fold in mice fed sucrose water as compared to water-fed control.Increased circulating cholesterol level: total cholesterol, but not HDL, levels are increased 30% in mice fed sucrose water as compared to water-fed control.Increased circulating triglyceride level: elevated plasma triglyceride levels observed in females at 15 weeks of age.Impaired glucose tolerance: mice fed sucrose water displayed an impaired glucose tolerance as compared to water-fed controlcardiovascular system.Vasculature congestion.Increased body weight:* mice fed sucrose water consistently gained weight over study time period (2 months- 8 months).* sucrose-fed mice increased body weight by 17% over water-fed controls.","C57BL/6 x C3H","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[1849,null,"B6.129-Tnfrsf1a<tm1Mak>/JWehi",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Nil","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","targeted mutation 1, Tak Mak","Tnfrsf1a<tm1Mak>","MGI:1857261","6",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[7632,null,"SJL/ASAM<MRI41948>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07"]
[5339,null,"C57BL/6-Tg(CAG-ATP7A)22Jmer/Apb",null,"Dominant",{"$nulls":25},"human ATPase, Cu++ transporting, alpha polypeptide","chicken beta-actin",{"$nulls":10},"The overall phenotype of transgenic mice was normal, and the transgene was transmissible to progeny, but the transgenic mice showed interesting changes in Cu concentration in various organs that were generally consistent with a role for ATP7A in efflux.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9",null,null,"No","2010-12-11","Cryopreserved sperm"]
[5666,"Cav-1 WT",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5189,null,"ENU18WT:007a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm"]
[7633,null,"SJL/ASAM<MRI92482>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[6630,"ABKO","B6.129X1-Adra1a<tm1Pcs>",null,"Recessive","Adra1a","adrenergic receptor, alpha 1a","Nil","Adra1c","MGI:104773","adrenergic receptor, alpha 1a; targeted mutation 1, Paul C Simpson","Adra1a<tm1Pcs>","MGI:2387663","14",{"$nulls":28},"Decreased vasoconstriction: homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone.Decreased heart rate variability: by ECG telemetry, conscious homozygotes show a 14% reduction in basal heart rate variability, suggesting increased sympathetic balance.Hypotension: * by tail cuff manometer and arterial catheter, conscious homozygotes are hypotensive at rest, with a ~10-15 mm Hg reduction in blood pressure (8-12% of wild-type mice) * tail cuff pressure is also reduced in a smaller cohort of homozygotes in the C57BL/6 background whereas heart rate is slightly but not significantly higher relative to wild-type mice * no differences in body weight, heart weight, heart histology, blood chemistry, blood cell counts, cardiac output or renal function are observed.","Hypotension: heterozygotes are intermediately hypotensive relative to wild-type and homozygous mutant mice","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[5340,"CTR1 Tg","C57BL/6-Tg(SLC31A1)Jmer",null,"Dominant",{"$nulls":25},"human Solute carrier family 31, member 1",{"$nulls":13},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-12-11"]
[7636,null,"SJL/ASAM<MRI33532>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7637,null,"SJL/ASAM<MRI47455>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7639,null,"SJL/ASAM<MRI135658>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7641,null,"SJL/ASAM<MRI58173>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[1859,"Eµ-myc/Bad ko","Un-Tg(IghMyc)22Bri Bad<tm1Sjk>/Wehi",null,"Dominant","BCL2-associated agonist of cell death","Bad","Nil","Bbc2","MGI:1096330","BCL2-associated agonist of cell death; targeted mutation 1, Stanley J Korsmeyer","Bad<tm1Sjk>","MGI:2675966","19",{"$nulls":15},"Yes","transgene insertion 22, Ralph L Brinster","Lymphoid-specific immunoglobulin heavy chain enhancer (Eμ)","B cell lineage",{"$nulls":9},"Excess pre-B cells in bone marrow. Animals develop high incidence pre-B and B lymphoma - Adult mortality: 80% More than 90% of Emu-myc mice die between 6 and 18 weeks of age (median 11 weeeks). Enlargement of all lymph nodes, spleen, infiltration of thymus (thymoma), bone marrow, liver, lung, weight loss.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[3944,"Line3","FVB/N-Tg(HBA1-GFP)3EW","FVB/N-Tg(HBA1-GFP)3EW","Dominant",{"$nulls":25},"Green Fluorescent Protein","α-Globin (-570 to +37) (4.1kb of enhancer)",{"$nulls":10},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2008-10-17"]
[7642,null,"SJL/ASAM<MRI132482>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07"]
[5673,"CD11c-DTR/GFP x C57 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5447,"Minnie ; ENU12NIH 71b CBA","ENU12NIH:071b CBA",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Small Mice","Normal","C57BL/6JAnu x CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","N/A","2","Sib x sib","No","2011-02-28","Cryopreserved sperm"]
[5674,"CD11cDTR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7638,null,"SJL/ASAM<MRI132159>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[7640,null,"SJL/ASAM<MRI130367>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[5163,"FVB x FVB.B6; Dirc-1","FVB/N;B6-Dircq1<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":37},"As per parental strain.Once injected with Alloxan mice are resistant to becoming diabetic (check via urine glucose or blood monitor), these mice do not show nephropathy and retinopathy disease consistent with the human conditions as compared to the B6;FVB/N-Dirc-1<FVB/N> strain. ","As per parental strain.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2010-06-29","Embryo"]
[7645,null,"B6/Mrit-114906","B6/Mrit-114906","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07"]
[6631,"ABKO","B6.129P2-Adra1b<tm1Cta>",null,"Recessive","adrenergic receptor, alpha 1b","Adra1b","Nil","alpha1B-adrenergic receptor","MGI:104774","adrenergic receptor, alpha 1b; targeted mutation 1, Susanna Cotecchia","Adra1b<tm1Cta>","MGI:2148638","11",{"$nulls":28},"Abnormal heart left ventricle morphology: left ventricular volume is higher.Decreased vasoconstriction: exhibit a reduction in mesenteric vascular responses to endogenous norepinephrine compared to wild-type, indicating reduced vasoconstriction in response to norepinephrine.Decreased cardiac muscle contractility: * phenylephrine-induced contractions of aortic rings are decreased by 25%. * baseline myocardial contractility is lower, as reflected by dP/dt. * transient bilateral carotid occlusion results in a minimal increase in myocardial contractility instead of the enhanced contractility seen in wild-type.Decreased heart rate: transient bilateral carotid occlusion results in a decrease in heart rate compared to a slight increase in treated wild-type, however baseline heart rate is normal.Abnormal systemic arterial blood pressure: * mean arterial blood pressure response to phenylephrine is decreased by 45% * mean arterial blood pressure response to norepinephrine is also decreased although to a lesser extent than seen with phenylephrine.Decreased systemic arterial blood pressure: exhibit impaired pressor response to a hypotensive stimulus, with marked attenuation in the change in systolic blood pressure and in the percent change in the end-systolic pressure-volume relationship after transient bilateral carotid occlusion.Decreased systemic arterial systolic blood pressure: baseline systolic blood pressure and Ea are lower.Impaired passive avoidance behaviour: 4-5 month old homozygotes show impaired retention of an inhibitory avoidance task after receiving a stressful electric stimuli.Decreased exploration in new environment: 4-5 month old homozygotes show significantly reduced horizontal exploratory activity and a reduced rearing behavior (vertical activity) in the open field.Abnormal baroreceptor physiology: transient bilateral carotid occlusion to test cardiovascular responses to a hypotensive stimuli produced an attenuated pressor response, indicating an abnormal baroreflex activity.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[6927,"ENU18:::B6:G1","ANU:ENU18:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm"]
[7373,"ATARI:kk:Cbl-bKO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> H2<k> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) ","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Ptsn>","MGI:2182940","10",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":11},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sib x sib","No","2013-07-08","Cryopreserved sperm"]
[7373,"ATARI:kk:Cbl-bKO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> H2<k> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb",null,"Cbl-b","MGI:2146430","Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[5164,"B6 x B6FVB; Dirc-1","B6;FVB/N-Dircq1<FVB/N>/ArcApb",null,"Dominant",{"$nulls":33},"diabetes induced renal changes 1","Dircq1",null,"6","As per parental strain.Once injected with Alloxan mice become diabetic (check via urine glucose or blood monitor), these mice show nephropathy and retinopathy disease consistent with the human conditions.  Mice are identified by conventional genotyping but on induction of diabetes phenotypes relating to type 1 diabetic complication are observed i.e. Excessive urination, weight loss and proteinuria. ","As per parental strain.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2010-06-29","Embryo"]
[6928,"ENU19:G1","ANU:ENU19:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm"]
[5166,"Idd5","NOD.B6-Idd5<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":37},"As per the parental strain (NOD/Lt).Delayed onset of Type 1 diabetes.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2010-06-29","Embryo"]
[4102,null,"KRN:231",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"4",null,"No","2008-12-04","Cryopreserved sperm"]
[32,"B-thy","C57BL/6JSfdAnu-Trp53<Bhy>/AnuApb","C57BL/6JSfdAnu-Trp53<Bhy>/AnuApb","Semi-dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","bthy","Trp53<Bhy>","MGI:3611889","11","ENSMUSG00000059552","ENSMUST00000108658","Trp53-201","412","540","T to C","ENSMUSE00000111826","5","138","Cysteine to Arginine",{"$nulls":4},"ATAAGCTATTCTGCCAGCTGGCGAAGACGTGCCCTGTGCAGTTGTGGGTCAGCGCCACACC","No",{"$nulls":13},"primitive hematopoietic or T cell leukemia,Sudden death,hemorrhage,Thymic lymphomaFibrosarcomaMultinodal lymphomaOsteosarcomaHaemangiosarcomaBrain tumourTeratocarcinoma","C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm"]
[6929,"ENU20:G1","ANU:ENU20:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm"]
[141,"Pebbles ; DD6","C57BL/6JSfdAnu-Tg(IghelD4)Ccg/AnuApb",null,"Dominant",{"$nulls":25},"IgD-only, anti-HEL H+L chain",null,"low level",{"$nulls":9},"Mice express IgD immunoglobulin reactive to Hen Egg lysozyme",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[7646,null,"B6/Mrit-107292","B6/Mrit-107292","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07"]
[5452,"PD","B6;129/Sv-Eif2ak2<tm1Cwe>/MarpApb",null,"Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Nil","dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449","eukaryotic translation initiation factor 2-alpha kinase 2; targeted mutation 1, Charles Weissmann","Eif2ak2<tm1Cwe>","MGI:2182566","17",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-02","Cryopreserved sperm"]
[7647,null,"B6/Mrit-amp","B6/Mrit-amp","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[4111,null,"KRN:172",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm"]
[6926,null,"c-mycδKI",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Unknown","1500006F24Rik, Bim, Bod","MGI:1197519",{"$nulls":3},"2",{"$nulls":28},"Unknown","Unknown","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-06-29","Cryopreserved sperm"]
[5684,"Chat tm1(cre/ERT)Nat /J",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5685,"ChAT-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7650,null,"B6/Mrit-da","B6/Mrit-da","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm"]
[5437,"Gq KO","B6.129-Gnaq<tm1>/Apb",null,"Semi-dominant","guanine nucleotide binding protein, alpha q polypeptide","Gnaq","Nil","Dsk1, Dsk10, G alpha q, Galphaq, Gq, GqI","MGI:95776",{"$nulls":3},"19",{"$nulls":28},"Small agouti mouse, gold stomach, black eyes and extremeties.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","6",null,null,"No","2011-02-16","Cryopreserved sperm"]
[6632,"Kit1","C57BL/6-Tg(Myh6-kit)1.1",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[4436,null,"C57BL/6-Tg(PDHA2-eGFP-MAP2cN)",null,"Recessive",{"$nulls":25},"Enhanced green fluorescent protein (GFP) fused to microtubule-associated protein 2 (human) (EGFP-MAP2cN)","pyruvate dehydrogenase E1 alpha 2 (PDHA2)",{"$nulls":10},"Appears to be infertile",null,null,"Yes","Yes","Yes","No","No","No","No","Poor",{"$nulls":3},"No","2009-02-17","Cryopreserved sperm"]
[7579,"Spi6 KO x OT-I","C57BL/6J-SerpinB9<tm1.1PIB> Tg(TcraTcrb)1100Mjb/MarpApb",null,"Dominant","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9","Nil","PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","MGI:3054907",{"$nulls":10},"Increased apoptosis:• apoptosis is increased in LCMV- and LM-specific CTLs in mutantsAbnormal CD8-positive, alpha-beta cytotoxic T cell morphology:• upon infection with LCMV Armstrong or a strain of Listeria monocytogenes (LM), numbers of LCMV-specific CTLs are reduced 5-fold and LM-specific CTLs are reduced 9-fold compared to control B6 mice.• frequency of CTLs devoid of Gzmb granules is 3 times greater than in controls; number of Gzmb granules per CTL is 2-fold lower than in controls.Abnormal cytotoxic T cell physiology:• apoptosis is increased in LCMV- and LM-specific CTLs in mutants.Defective cytotoxic T cell cytolysis:• deficit in CTL activity is observed in ex vivo activity assay over course of LCMV infection; on day 10, activity is decrease 6-fold compared to controls.Abnormal enzyme/ coenzyme level:• caspase 3 in cytoplasm is increased.Abnormal enzyme/coenzyme activity:• GranzymeB activity is significantly increased in cytoplasm of mutants compared to controls.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Spi6 KO mice mated with  OT-I mice","No","2014-01-28","Cryopreserved sperm"]
[6633,"Kit2","C57BL/6-Tg(Myh6-kit)1.2",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[4771,"c-cbl KO","C57BL/6-Cbl<tm1Ddlb> ",null,"Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2009-07-28"]
[4829,"6AT:35","ENU6AT:035",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[207,"Tbx20 floxed","Tbx20<tm1Rph>",null,"Recessive","T-box 20","Tbx20","Nil","Tbx12","MGI:1888496","targeted mutation 1, Richard P Harvey","Tbx20<tm1Rph>","MGI:3579478","9",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[7273,"ENU20 017b ; ENU20:017b","C57BL/6NCrlAnu-Dock2<m3Anu>/AnuApb","C57BL/6NCrlAnu-Dock2<m3Anu>/AnuApb","Recessive","dedicator of cyto-kinesis 2","Dock2","Unknown","CED-5, Hch, MBC ","MGI:2149010","dedicator of cyto-kinesis 2; mutation 3, The Australian National University","Dock2<m3Anu>","MGI:5563488","11","ENSMUSG00000020143","ENSMUST00000093193","Dock2-001","3921","3990","T to A","ENSMUSE00000351317","39","1307","Tyrosine to STOP",{"$nulls":4},"AGCCTGTGCAAGGAACTGGCGGAACAATATGAGATGGAGATCTTTGACTACGAGCTACTCA",{"$nulls":13},"Decreased CD4<+> T cells. Increased CD44<hi> expression in CD4 and CD8 T cells.","Normal","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","0","G6","Het x Het","No","2013-02-12","Cryopreserved sperm"]
[2775,null,"C57BL/6-Tg(hK14-FLII)36",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT C57BL/6","No","2008-02-16"]
[1360,null,"NOD.B6 Idd3r450",null,"Dominant","insulin dependent diabetes susceptibility 3","Idd3","Unknown","Idd-3","MGI:96405",{"$nulls":3},"3",{"$nulls":15},"Yes",{"$nulls":12},"Idd3 is a diabetes susceptibility QTL mapping to a 145 kb interval on mouse Chromosome 3 around 19.2 cM. Il2 colocalizes with Idd3 and has been suggested as a candidate gene.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Unknown","pRb, Rb, Rb-1","MGI:97874","targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":15},"Yes",{"$nulls":12},"Compound mutant: Mild anaemia.  Single Epo-R-Cre – lethal as homozygous, heterozygous maintained only.  Single pRbfl/fl – no phenotype until Cre exposedeYFP reporter for tracking of deleted cells in vivo","heterozygous mice are normal, viable and non-anaemic (only pRbfl/fl are anaemic)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Epor<tm1(EGFP/cre)Uk> -ve  Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj> female x Epor<tm1(EGFP/cre)Uk> +ve  Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj> het male","No","2014-02-14","Cryopreserved sperm"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","erythropoietin receptor","Epor","Unknown",null,"MGI:95408","erythropoietin receptor; targeted mutation 1, Ursula Klingmuller","Epor<tm1(EGFP/cre)Uk>","MGI:3052727","9"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Increased","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6"]
[1550,null,"BALB/c-Tg(iFABPp-TGFb1)  ",null,"Recessive",{"$nulls":25},"transforming growth factor, beta 1","at intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP  linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences).","high",{"$nulls":9},"Restricted expression of TGF beta transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor","Tnf","Normal","DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha","MGI:104798","targeted mutation 2, Jonathon D Sedgwick","Tnf<tm2Jods>","MGI:3578747","17",{"$nulls":15},"Yes","Neomycin resistance gene",{"$nulls":11},"Normal. Control of APB ID#2395",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Unknown","memTNF, memTNFdelta","MGI:1314884","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1a<tm1Imx>","MGI:1857468","Unknown"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor receptor superfamily, member 1b","Tnfrsf1b","Unknown","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314883","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1b<tm1Imx>","MGI:1860087","Unknown"]
[6634,"Wv1","C57BL/6-Tg(Myh6-Kit<W-v>)2.1",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit<W-v>","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit(W-v> allele in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20"]
[638,"HtrA3-KO (MP10 Cre65)","C57BL/6-Htra3<tm1>",null,"Dominant","HtrA serine peptidase 3","Htra3","Nil","2210021K23Rik, 9530081K03Rik","MGI:1925808",{"$nulls":3},"5",{"$nulls":15},"Yes",{"$nulls":12},"Mice are fertile and do not show any clear signs of immunodeficiency.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-04-25","Cryopreserved sperm"]
[7068,"Momme D32","FVB/NJ-Dnmt1<MommeD32> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","DNA methyltransferase (cytosine-5) 1","Dnmt1","Unknown","Cxxc9, Dnmt1o, MommeD2, MTase","MGI:94912","MommeD33",null,null,"9",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD32<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-29","Cryopreserved sperm"]
[208,"Tbx5 KO","Tbx5<tm1.1Jse>",null,"Recessive","T-box 5","Tbx5","Unknown",null,"MGI:102541","targeted mutation 1.1, Jonathan G Seidman","Tbx5<tm1.1Jse>","MGI:2387851","5",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal (do not survive past day E10.5), abnormal cardiac and forelimb development.  ","Model for Holt Oram Syndrome","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[4739,"Wink","C.129-Tg(hGM-CSFRb) Csf2rb<tm1Clsc> Csf2rb2<tm1Cgb>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Unknown","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":15},"Yes","human beta common chain receptor for GM-CSF/IL-3/IL-5","pgk","very low",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10","0","Purchased BALB/c mated with transgenic mouse from colony to maintain colony","No","2009-04-20","Cryopreserved sperm"]
[4739,"Wink","C.129-Tg(hGM-CSFRb) Csf2rb<tm1Clsc> Csf2rb2<tm1Cgb>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)","Csf2rb2","Unknown","AIC2A, BetaIl3, Bil3, Il3r, Il3rb2","MGI:1339760","targeted mutation 1, C Glenn Begley","Csf2rb2<tm1Cgb>","MGI:3652583","15"]
[206,"Tbx20 KO","Tbx20<tm1.1Rph>",null,"Recessive","T-box 20","Tbx20","Nil","Tbx12","MGI:1888496","targeted mutation 1.1, Richard P Harvey","Tbx20<tm1.1Rph>","MGI:3579836","9",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal ~E10.5.  Abnormal cardiac and yolk sac development.Failure of looping morphogenesis-looping is blocked.","None reported","C57BL/6 x 129","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[5687,"ChAT-EGFP x SOD1G93A",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6932,"Crim1FLOX","B6.129/Ola-Crim1<tm1>/Uqbr",null,"Recessive","cysteine rich transmembrane BMP regulator 1 (chordin like)","Crim1","Nil",null,"MGI:1354756","Crim1FLOX",null,null,"17",{"$nulls":28},"Normal","Normal","Predominantly C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",">6",null,null,"No","2012-07-05"]
[221,"Chisel KO","C57BL/6-Smpx<tm1Rph>/Apb",null,"Recessive","small muscle protein, X-linked","Smpx","Unknown","chisel, Csl","MGI:1913356","targeted mutation 1, Richard P Harvey","Smpx<tm1Rph>","MGI:2387819","X",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null mutation do not exhibit defects in heart or skeletal muscle morphology or development","No reported phenotype","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm"]
[1937,null,"BALB/c.B6-IL13<tm2Anjm> Ccl11<tm1Mer>/AnuApb",null,"Recessive","interleukin 13","Il13","Unknown","Il-13","MGI:96541","targeted mutation 2, Andrew NJ McKenzie","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":15},"Yes",{"$nulls":14},"BALB/c ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-29","Cryopreserved sperm"]
[1937,null,"BALB/c.B6-IL13<tm2Anjm> Ccl11<tm1Mer>/AnuApb",null,"Recessive","small chemokine (C-C motif) ligand 11","Ccl11","Nil","eotaxin, Scya11","MGI:103576","chemokine (C-C motif) ligand 11; targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11"]
[5693,"CMV Cre (CreDel)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5136,"A9","C57BL/6-Tg(TcrbB3)8Cbn/CbnApb",null,"Dominant",{"$nulls":25},"transgene insertion TcrbB3, Francis R Carbone","Tcrb","More than 10 copies",{"$nulls":9},"The majority of CD8 T cells express the trangenic Vb5.2 T cell receptor.","As for homozygous.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"br","No","2010-05-26","Cryopreserved sperm"]
[212,"Nkx2-5 Cre","B6.129-Nkx2-5<tm2(cre)Rph>",null,"Recessive","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Normal","Csx, Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","targeted mutation 2, Richard P Harvey","Nkx2-5<tm2(cre)Rph>","MGI:2448972","17",{"$nulls":15},"No","Cre Recombinase","Nkx2-5",{"$nulls":10},"Normal","Normal","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[6255,"B6 Caspase -2/9","B6.129-Casp2<tm1Vaux> Casp9<tm1Flv>",null,"Recessive","caspase 2","Casp2","Nil","Caspase-2, Ich-1, Nedd2","MGI:97295","caspase 2; targeted mutation 1, David L Vaux","Casp2<tm1Vaux>","MGI:3609949","6",{"$nulls":28},"Perinatal Abnormal brain development:*At E14.5 a majority of embryos display brain over-growth similar to that found in Casp9<tm1Flv> homozygotes.Abnormal T cell physiology:*Thymocytes grown in wildtype hosts have only 10-20% of the DEVD-ase activity of wildtype or thymocytes deficient for only caspase 2.Hematopoietic system phenotype:*Irradiated wildtype hosts reconstituted with E14.5 Casp2<tm1Vaux> Casp9<tm1Flv> double homozygous fetal liver develop normal thymocyte numbers and sub-populations with no thymocyte upregulation of caspases 1, 3, 6, 7, 8, or 9, normal B cell and T cell apoptosis in response to cytokine withdrawal, and normal T cell sensitivity to dexamethasone.*Dexamethasone induced apoptosis of T cells (grown in wildtype hosts from E14.5 fetal liver) is blocked by caspase inhibitors but not by calpain and cathepsin inhibitors.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6255,"B6 Caspase -2/9","B6.129-Casp2<tm1Vaux> Casp9<tm1Flv>",null,"Recessive","caspase 9","Casp9","Nil","Caspase-9, ICE-LAP6, Mch6","MGI:1277950","caspase 9; targeted mutation 1, Richard A Flavell","Casp9<tm1Flv>","MGI:2158755","4"]
[639,"Vav-rtTA","B6.129-Tg(Vav-rtTA)/Apb",null,"Dominant",{"$nulls":25},"reverse tetracycline transactivator","vav","haemopoietic specific expression",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","9","0",null,"No","2007-04-25","Cryopreserved sperm"]
[29,"Babe","C57BL/6JSfdAnu-Agtpbp1<babe>/AnuApb","C57BL/6JSfdAnu-Agtpbp1<babe>/AnuApb","Recessive","ATP/GTP binding protein 1","Agtpbp1","Unknown","Nna1","MGI:2159437","ATP/GTP binding protein 1; babe","Agtpbp1<babe>","MGI:3847121","13","ENSMUSG00000021557","ENSMUST00000022040","Agtpbp1-201","2413","2543","C to T","ENSMUSE00000118960","19","804","Arginine to STOP",{"$nulls":4},"ACATTTGTTACTACAAAAATCACTTCTCACGAAGCTCAGTTGCCGCAGGCGGACAGAAGGG","No",{"$nulls":12},"Lethal dilute ataxia, weakness of the hindlimbs and mild uncoordination (ataxia) which is usually detectable at weaning.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm"]
[133,"Homer","B10.Cg-H2<k2> Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb","B10.Cg-H2<k2> Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb","Dominant",{"$nulls":25},"transgene insertion 1, Richard J Cornall","dopachrome tautomerase (Dct) ; Trp2, Tyrp2 ","Melanocyte specific","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k2 variant","H2<k2>","MGI:4936842","17","Mice develop a spontaneous autoimmune disease with striking similarity to human vitiligo vulgaris and Vogt-Koyanagi-Harada syndrome. ",null,"C57BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5",null,"No","2006-02-06","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 1, Richard J Cornall","dopachrome tautomerase (Dct) ; Trp2, Tyrp2 ","Melanocyte specific"]
[5400,"FVB x FVB.B6 ; Dirc-3","FVB/N;B6-Dircq3<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":28},"Unknown","Unknown",{"$nulls":3},"diabetes induced renal changes 3","Dircq3",null,"6","As per parental strain.Once injected with Alloxan mice are resistant to becoming diabetic (check via urine glucose or blood monitor), these mice do not show nephropathy and retinopathy disease consistent with the human conditions as compared to the B6;FVB/N-Dirc-3<FVB/N> strain. ","As per parental strain.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2011-01-31","Embryo"]
[6264,"del 362","C57BL/6-Dnmt3l<tm1Scot>",null,"Dominant","DNA (cytosine-5-)-methyltransferase 3-like ","Dnmt3l","Nil","D6Ertd14e, ecat7","MGI:1859287","DNA (cytosine-5-)-methyltransferase 3-like; targeted mutation 1, Hamish S Scott","Dnmt3l<tm1Scot>","MGI:3574947","10",{"$nulls":28},"Abnormal seminiferous epithelium morphology:*The epithelium has a vacuolated appearance.Azoospermia:*Germ cells are lost through apoptosis and sloughing with many tubules containing only Sertoli cells.Arrest of male meiosis:*At P14 in first spermatogenic wave a build up of leptotene and zygotene spermatocytes is seen with no cells progressing beyond stage IV.*At P70 only leptotene spermatocytes and spermatogonia are present.*The pachytene synaptonemal complex is not seen.Small gonad:*Adults display severe hypogonadism.Infertility",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7616,"EphA2 Knockout , EphA2 Reporter","B6.129-Epha2<Gt(ROSABetageo)CN3Yiw>/QimrApb",null,"Recessive","Eph Receptor A2","EphA2",null,"Eck, Myk2, Sek2, Sek-2","MGI:95278","Eph receptor A2; gene trap CN3, Yoichiro Iwakura","Epha2<Gt(ROSABetageo)CN3Yiw>","MGI:2448472","4",{"$nulls":28},"Abnormal tail morphology:• abnormal blood vessel formation in the tailsAbnormal caudal vertebrae morphology:• ectopic tail vertebra formationShort tail:• varying degrees of short tails, first seen around E12.5-13.5Kinked tail:• 40% exhibit varying degrees of kinky tails, first seen around E12.5-13.5Abnormal axial mesoderm:• aberrant axial mesoderm formationAbnormal neural tube morphology/development:• the wall of the neural tube in tails is thickened and multi-layeredSplit notochord:• notochord is abnormally bifurcated at the caudal end between E11.5 and E12.5 and the bifurcated notochords are abnormally intertwined• notochordal cells are spread broadly into the tail budAbnormal neural tube morphology/development:• the wall of the neural tube in tails is thickened and multi-layeredAbnormal vascular development:• abnormal blood vessel formation in tails, with the number of blood vessels changed and larger vessel caliberskeletonabnormal caudal vertebrae morphology ( J:69393 )• ectopic tail vertebra formationAbnormal sclerotome morphology• ectopic slerotomes form at the caudal tail where the bifurcated notochords form","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,"Homozygous x Homozygous","No","2014-03-07","Cryopreserved sperm"]
[6933,"ENU19 WT:001:b:B6:G3","ANU:ENU19WT:001:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[145,"RAMA:Hamlet","C57BL/6JSfdAnu-Tg(H2-sHEL)Ccg Tg(IghelMD4)4Ccg/AnuApb","C57BL/6JSfdAnu-Tg(H2-sHEL)Ccg Tg(IghelMD4)4Ccg/AnuApb","Recessive",{"$nulls":25},"soluble Hen Egg Lysozyme dimeric molecule","H-2k","Low",{"$nulls":11},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"13",null,"No","2006-02-06","Cryopreserved sperm"]
[{"$nulls":30},"soluble Hen Egg Lysozyme dimeric molecule","H-2k","Low"]
[1532,null,"BALB/c-IL9<tm1Anjm>/AnuApb",null,"Recessive","interleukin 9","Il9","Nil","Il-9, P40","MGI:96563","targeted mutation 1, Andrew NJ McKenzie","IL9<tm1Anjm>","MGI:2656470","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mice are viable and show no overt phenotype, however when challenged, aspects of the inflammatory response are shown to be impaired.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2007-07-05","Cryopreserved sperm"]
[4831,"6CAT:004","ENU6CAT:004",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[6934,"ENU19 WT:002:b:B6:G3","ANU:ENU19WT:002:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6935,"ENU19 WT:005:b:B6:G3","ANU:ENU19WT:005:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6937,"ENU19 WT:008:b:B6:G3","ANU:ENU19WT:008:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[7670,"ENU31:G2","ANU:ENU31:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-05-02","Cryopreserved sperm"]
[1953,"PDGFRa floxed","Un-Pdgfra<tm8Sor>",null,"Recessive","platelet derived growth factor receptor, alpha polypeptide","Pdgfra","Normal","CD140a, Pdgfr-2","MGI:97530","targeted mutation 8, Philippe Soriano","Pdgfra<tm8Sor>","MGI:2449440","5",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129S4","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-03"]
[7628,"EphA1 Knockout","B6.129-Epha1<tm1Sld>/QimrApb",null,"Recessive","Eph receptor A1","Epha1",null,"5730453L17Rik, Eph, Esk","MGI:107381","Eph receptor A1; targeted mutation 1, Shannon L Duffy","Epha1<tm1Sld>","MGI:3822370","6",{"$nulls":28},"A Homozygous (PLAP/PLAP) mouse will result in the normal phenotype displaying PLAP activity however EphA1 expression will be lost.Endometrium inflammation:\t• mice exhibit endometrium inflammation secondary to hydrometrocolpos.Vaginal inflammation:• mice exhibit inflammation of the vaginal mucosa secondary to hydrometrocolpos.Dilated uterine horn:\t• mice exhibit dilated, attenuated uterine horns secondary to hydrometrocolpos.Enlarged uterus:• mice exhibit an enlarged uterus due to an accumulation of clear uterine fluid (hydrometrocolpos).Increased uterus weight.Vagina atresia:• 18% of mice exhibit a failure of vaginal opening.• despite normal estrogen receptor expression, beta-estradiol treatment fails to induce precocious vaginal opening in P12 mice unlike in wild-type mice and vaginal opening can not be induced by likewise treating affected adult mice.Hydrometrocolpos:\t• mice exhibit inflammation of the vaginal mucosa and endometrium with dilated, attenuated uterine horns secondary to hydrometrocolpos.Female infertility:\t• female mice affected by hydrometrocolpos are sterile.Kinked tail:• up to 80% of mice exhibit a kinky tail due to incorrectly positioned caudal vertebrae.Distended abdomen: • in some mice due to an enlarged uterusAbnormal response/metabolism to endogenous compounds:• treatment with beta-estradiol fails to induce apoptosis in the lower genital tract and precocious vaginal opening unlike in wild-type mice.Skeleton phenotype: • despite a kinky tail, mice exhibit normal skeletal morphology.","Normal PLAP activity with EphA1 expression.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,null,"No","2014-04-04","Cryopreserved sperm"]
[5202,"Tmem26 conditional knockout","C57BL/6-Tmem26<tm1>/UqbrApb",null,"Recessive","Transmembrane protein 26","Tmem26","Nil",null,"MGI:2143537",{"$nulls":3},"10",{"$nulls":15},"Yes",{"$nulls":12},"Normal,ubiquitous deletion of floxed region also produces normal animals.","normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","2 crosses from founder mouse (derived from a C57 cell line) to C57 mice","approx. 7",null,"No","2010-08-06","Cryopreserved sperm"]
[6936,"ENU19 WT:007:b:B6:G3","ANU:ENU19WT:007:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[148,"NODScid","NOD;Cg-H2<k> Prkdc<scid>/AnuApb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":12},"SCID mutation prevents TCR and BCR rearrangements. This prevents maturation of B and T cells at very early stages of development. These mice, therefore lack, T and B cells in periphery. Please refer to MGI allele page for further information using the link above.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"19",null,"No","2006-02-06","Cryopreserved sperm"]
[1946,null,"BALB/c.B6-Gata1<tm6Sho> Il5<tm1Kopf>/AnuApb",null,"Recessive","GATA binding protein 1","Gata1","Unknown","Gata-1, Gf-1","MGI:95661","GATA binding protein 1; targeted mutation 6, Stuart Orkin","Gata1<tm6Sho>","MGI:3037864","X",{"$nulls":15},"Yes",{"$nulls":12},"No eosinophils",null,"BALB/c ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-01","Cryopreserved sperm"]
[1946,null,"BALB/c.B6-Gata1<tm6Sho> Il5<tm1Kopf>/AnuApb",null,"Recessive","interleukin 5","Il5","Unknown","IL-5","MGI:96557","targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11"]
[5516,"Gwendolin","B6.(Cg)-Gstp1/Gstp2<tm1Wolf>",null,"Recessive","glutathione S-transferase, pi 1","Gstp1","Nil","Gst p-1, GstpiB","MGI:95865","targeted mutation 1, C Roland Wolf","Gstp1/Gstp2<tm1Wolf>","MGI:3046099","19",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.  Studying allergic airway disease compared with allergic WT mice, eosinophilia, goblet cell hyperplasia, airway remodeling, lung resistance, and IL-5 were enhanced in allergic Gstp-null mice.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","6",null,null,"No","2011-06-01"]
[5516,"Gwendolin","B6.(Cg)-Gstp1/Gstp2<tm1Wolf>",null,"Recessive","glutathione S-transferase, pi 2","Gstp2","Nil","Gst p-2, Gst-3, Gst3, GSTpiA","MGI:95864","glutathione S-transferase, pi 2; targeted mutation 1, C Roland Wolf","Gstp1/Gstp2<tm1Wolf>","MGI:3046101","19"]
[4085,null,"ENU7PMH:139, Metabolic Lean 3",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Low percentage of body fat when fed on a high fat diet.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[2442,"Koy","C57BL/6JSfdAnu-Coro1a<koy>/Apb","C57BL/6JSfdAnu-Coro1a<koy>/Apb","Recessive","coronin, actin binding protein 1A","Coro1a","Reduced","Clabp, coronin 1, Lmb3, p57","MGI:1345961","coronin, actin binding protein 1A; koyaanisqatsi","Coro1a<koy>","MGI:3818509","7","ENSMUSG00000030707","ENSMUST00000106364","Coro1a-002","76","329","G to A","ENSMUSE00000202191","2","26","Glutamic acid to Lysine",{"$nulls":4},"GACAGCCAGCCAAGGCTGACCAGTGCTATGAGGATGTGCGCGTCTCACAAACCACTTGGGA","Yes",{"$nulls":12},"Mice have few peripheral blood CD4 or CD8 T cells. T cells are also reduced in spleen and LN. There is reduced transwell migration of thymocytes and naive mature T cells to SDF (CXCL12) or to ELC (CCL21). Elevated phalloidin staining (elevated F actin). Decreased CD4-positive T cell number: CD4+ T cell numbers in the periphery are significantly decreased about 5-fold.Decreased CD8-positive T cell number: CD8+ T cell numbers in the periphery are significantly decreased about 5-fold.Decreased thymocyte number: the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice.Abnormal T cell physiology:* in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12.* similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21.","Slight T cell deficit.","C57BL/6JStdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5",null,"No","2008-01-14","Cryopreserved sperm"]
[6938,"ENU19 WT:012:a:B6:G3","ANU:ENU19WT:012:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6466,"LSM16Δ","C57BL/6-Edc3<tm1(KOMP)Vlcg>Ausb ?",null,"Recessive","enhancer of mRNA decapping 3 homolog (S. cerevisiae)","Edc3","Nil","Lsm16, Yjdc","MGI:2142951","enhancer of mRNA decapping 3 homolog (S. cerevisiae); targeted mutation 1, Velocigene","Edc3<tm1(KOMP)Vlcg>","MGI:5292973","9",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6940,"ENU19 WT:014:a:B6:G3","ANU:ENU19WT:014:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[5701,"Crim1 Flox C57 R26R",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[1977,"SMAD1Δ","Swiss-Smad<tm1Rob>",null,"Recessive","MAD homolog 1 (Drosophila)","Smad1","Nil","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 1, Elizabeth J Robertson","Smad1<tm1Rob>","MGI:2155483","8",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality during organogenesis: homozygotes are present at the expected Mendelian ratios at E9.5 but die by E10.5.Abnormal embryogenesis/ development: homozygous mutant embryos are often abnormally positioned within the yolk sac.Incomplete embryo turning: at E9.5-E10.0, a subset of homozygotes exhibit incomplete embryo turning.Abnormal mesoderm development: at E7.0, homozygotes display extensive twisting of the newly formed mesoderm along the proximodistal axis.Decreased embryo size: homozygous mutant embryos are often smaller than wild-type embryos.Abnormal embryonic epiblast morphology: by E7.0, homozygotes display extensive twisting of the epiblast along the proximodistal axis.Disorganized embryonic tissue: homozygotes display severe distortion of the embryonic region.Abnormal extraembryonic tissue morphology.Abnormal allantois morphology:* at E8.0, homozygotes exhibit absence of a recognizable allantoic bud; only a small allantoic rudiment is observed at E8.5.* by E9.5, three allantois phenotypes are observed: a balloon-like structure with peripheral blood-filled vessels; a dense structure filled with compact mesenchyme and small blood-filled sacs; occasionally, an allantoic rudiment that fuses peripherally and non-uniformly with the chorionic surface of the placenta.Abnormal chorion morphology: at E8.5, homozygotes show overproliferation of chorionic tissue, as well as aberrant folding of the chorion within the exocoelomic cavity and defective proximal migration.Abnormal extraembryonic endoderm formation:* at E7.0, homozygotes exhibit a localized outpocketing of the visceral endoderm at the posterior embryonic/extraembryonic junction.* despite ruffling of the visceral endoderm at E8.0-E8.5, the emerging AP axis is symmetrical, headfolds and somites form, gross visceral yolk sac morphology and mesoderm appear normal, and the node is clearly defined.Abnormal placenta morphology: homozygotes fail to establish a functional placental connection.Abnormal chorioallantoic fusion: occasionally, an allantoic rudiment fuses peripherally and non-uniformly with the chorionic surface of the placenta.Abnormal umbilical cord morphology: homozygotes fail to form the umbilical connection to the placenta.Decreased primordial germ cell number:* at E8.5, homozygotes show a significant reduction in the number of primordial germ cells.* 6 of 14 (43%) have no PGCs, 5 of 14 (36%) have fewer than ten and 3 of 14 (21%) have less than 25.Distended pericardium: at E9.5-E10.0, a subset of homozygotes exhibit a distended pericardium.Decreased embryo size: homozygous mutant embryos are often smaller than wild-type embryos.Abnormal ventral body wall: at E9.5-E10.0, a subset of homozygotes exhibit delayed ventral closure.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04"]
[7697,"IFNe 202 flp<#65>(FF)","C57BL/6-Ifne<tm1.1Pjh>/MarpApb",null,"Recessive","Interferon epsilon","Ifne","Normal","Ifne1, Ifnt1 ","MGI:2667156","interferon epsilon; targeted mutation 1.1, Paul J Hertzog","Ifne<tm1.1Pjh>","MGI:5503221","4",{"$nulls":28},"Normal wild-type","Normal wild-type","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm"]
[1978,"Smad1f","Swiss-Smad1<tm2Rob>",null,"Dominant","MAD homolog 1 (Drosophila)","Smad1","Normal","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04"]
[6939,"ENU19 WT:012:b:B6:G3","ANU:ENU19WT:012:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[277,null,"FVB-Tg(Myl1-Igf1)1Nros",null,"Recessive",{"$nulls":25},"transgene insertion 1, Naida Rosenthal","skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus","restricted to skeletal muscle",{"$nulls":9},"Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-1 transgenic models. Expression of GATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic of younger animals.",null,"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-02"]
[6269,"DO11-10","BALB/c-Tg(DO11.10)10Dlo",null,"Semi-dominant",{"$nulls":25},"transgene insertion 10, Dennis Y Loh",{"$nulls":11},"Decreased CD4-positive T cell number:*CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide.Decreased double-positive T cell number:*CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide.Abnormal thymus physiology:*20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes.*Apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas.*3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla.*Peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6941,"ENU19 WT:018:a:B6:G3","ANU:ENU19WT:018:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6943,"ENU19 WT:019:a:B6:G3","ANU:ENU19WT:019:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[320,null,"B6.129-Rag1<tm1Mom>/Apb",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-04","Cryopreserved sperm"]
[7698,"R26 WT-Hoxa1 ki","C57BL/6-Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"Semi-dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 3237, TaconicArtemis","Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"6",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm"]
[5409,"NOD.IL-12KO","NOD/Lt-IL12b<tm1Jm>/ArcApb",null,"Recessive","interleukin 12b","Il12b","Unknown","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","interleukin 12b; targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":15},"Yes",{"$nulls":12},"Phenotype on NOD/Lt background is unknown to the APB.However, the phenotype on 129 x C57BL/6 is as follows:Decreased circulating interferon-gamma level:* serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls.Abnormal macrophage physiology:* fewer than expected macrophages in the dermis of carcinogen treated skin.Abnormal granulocyte physiology:* fewer than expected granulocytes in the dermis of carcinogen treated skin.Abnormal lymphocyte physiology:* lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased.Abnormal NK cell physiology:* mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls.Abnormal CD8-positive T cell physiology:* dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin.Decreased interleukin-17 secretion:* barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17.Increased susceptibility to bacterial infection:* vaccination does not produce a protective response to M. tuberculosis.Decreased susceptibility to type IV hypersensitivity reaction:* specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type.Decreased incidence of chemically-induced tumors:* resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol.* however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells.Abnormal CD4-positive T cell physiology:* 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type.* 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type.* draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2011-02-03","Embryo"]
[6312,"B6Noxa/339/Ova","Noxa X BIM 216 /Rip-mOva",{"$nulls":3},"  Noxa       Bim     RipmOVA  ",{"$nulls":35},"Increased numbers of lymphoid and myeloid cells. Spleen and lymph nodes are 2-3-fold bigger than in wt. Sternum is sticking out.  Bim-/- females are bad mothers and should not be used for breeding unless necessary.  Bim -/-:  blood - increased lymphocytes (B + T cells), granulocytes & monocytes. - decreased platelets - Increased serum Ig.  Thymus - fewer pre T cells.  Age 1 year - lymphadenopathy - 55% -/-, 35% +/- mice sick with kidney disease or cardiac infarction/vasculitis.  Fewer -/- females born. When born, often have poorly formed reproductive organs.  -/- have protruding sternum.  No phenotype with additional loss of noxa. ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7701,"B3K506 Tcra/b","C57BL/6-Tg(CD2-Tcra, -Tcrb)506/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor alpha, T cell receptor beta","Human CD2",{"$nulls":10},"Transgenic mice express the rearranged B3K506 Va4.1 and Vβ8.1 chains using the human CD2 promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm"]
[7699,"YAe62 Tcrb","C57BL/6-Tg(CD2-Tcrb)62/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor beta","Human CD2",{"$nulls":10},"YAe62 β mice are biased toward creating TCRs reactive to IAb-3K and the related ligand IAb-P-1K.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","immunoglobulin heavy chain complex","Igh",null,null,"MGI:96442","immunoglobulin heavy chain complex; targeted mutation 1, Robert Brink","Igh<tm1Rbr>","MGI:3800383","12",{"$nulls":15},"Yes","transgene insertion 1, Robert Brink",{"$nulls":11},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-02-13","Cryopreserved sperm"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","dedicator of cytokinesis 8","Dock8",null,"1200017A24Rik, 5830472H07Rik, A130095G14Rik","MGI:1921396","primurus","Dock8<pri>","MGI:3835421","19",{"$nulls":16},"transgene insertion 1, Robert Brink"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1"]
[7700,"B3K506 Tcrb","C57BL/6-Tg(CD2-Tcrb)506/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor beta","Human CD2",{"$nulls":10},"TCRβ Tg mice express the rearranged B3K506 Vβ8.1 chain using the human CD2 promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm"]
[6310,"NOD.scid","NOD.CB17-Prkdc<scid>/JWehi",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":28},"Increased circulating glucose level:*Following treatment with streptozotocin, mice exhibit increased glucose serum levels that can be restored to euglycemic levels by engraftment of human islet cells.*Following intraperitoneal injection of human peripheral blood mononuclear cells, 11 of 12 streptozotocin-treated mice engrafted with human islet cells exhibit increased glucose serum levels although not as high as pre-transplantation.Abnormal response to transplant:*While human islet engrafts in streptozotocin-treated mice appear normal after 4 weeks, subsequent injection of human peripheral blood mononuclear cells results in destructive infiltrate into the human islet graft site, inflammation, loss of engrafted islet beta cells, fibrosis, and necrosis after 3 weeks.*However, this rejection is not due to graft versus host disease.",null,"NOD/LtSz ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Nil","Cd79a, Ig alpha, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a<tm1(cre)Reth>","MGI:3687451","7",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","PR domain containing 1, with ZNF domain","Prdm1","Normal","Blimp-1, Blimp1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","signal transducer and activator of transcription 3","Stat3","Nil","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 1, Valeria Poli","Stat3<tm1Vpo>","MGI:2384507","11"]
[4117,"Patchy","ENU12NIH:037a",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"White patch on underbelly. One mouse in G2 seen with white patch as well as curly tail.","White patch on underbelly. One mouse in G2 seen with white patch as well as curly tail.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm"]
[31,"Blobby","C57BL/6JSfdAnu-Alms1<bbb>/AnuApb","C57BL/6JSfdAnu-Alms1<bbb>/AnuApb","Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","blobby","Alms1<bbb>","MGI:3611799","6","ENSMUSG00000063810","ENSMUST00000072018","Alms1-001","6392","6507","T to A","ENSMUSE00000552223","10","2130","Leucine to STOP",{"$nulls":4},"TCTTCTTTCTGAAGGTCAGGATTATGAGTTAGAAGAGGTTCAGCATATACCTCAGTCATAC","No",{"$nulls":12},"Late onset obesity (apparent at 3-6 months).  Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss.",null,"C57BL/6JStdAnu","Yes","No","Yes","Yes","No","Yes","Yes","Poor",null,"10",null,"No","2006-02-06","Cryopreserved sperm"]
[2368,"thiana","ENU5AT:149 ",null,"Recessive",null,null,"Unknown",null,null,"thiana",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[2371,null,"ENU7B6:021",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[2778,"BALB/c.hK14-FLII 5","BALB/c-Tg(hK14-FLII)5/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT BALB/c","No","2008-02-16","Cryopreserved sperm"]
[4747,"Gelsolin KO ; Gen","STOCK Gsn<tm1Djk>/AnuApb",null,"Recessive","gelsolin","Gsn","Nil",null,"MGI:95851","targeted mutation 1, David J Kwiatkowski","Gsn<tm1Djk>","MGI:2179509","2",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development. Have defects in cell motility, as might be expected for a protein involved in cytoskeletal actin filament regulation.",null,"Unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2009-04-27","Cryopreserved sperm"]
[6336,"Tbx1 BAC","Tbx1 BAC Transgenic",{"$nulls":3},"  Tbx1    ",{"$nulls":35},"May die suddenly.",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2463,null,"B6.CBA-Tg(hGMCSF-2CK1)1236/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm"]
[6942,"ENU19 WT:018:b:B6:G3","ANU:ENU19WT:018:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[3323,"Metallic","ENU10B6:031 ",null,"Recessive",{"$nulls":37},"Silver / grey coat. Mice appear otherwise healthy and are able to breed.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"1",null,"No","2008-06-15","Cryopreserved sperm"]
[2380,"Jaffa","ENU8B6:085",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Coat colour defect.Dluted coat colour.Irregular coat pigmentation.Affected mice are born with a brown-coloured coat. Mice appear healthy otherwise. ",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[2466,null,"B6.CBA-Tg(hGMCSF-2KB)63/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm"]
[2468,null,"B6.CBA-Tg(hGMCSF-KBM)498/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm"]
[6334,"STAT6/Blimp424","C57BL/6-Prdm1<tm1Nutt> Stat6<tm1Aki>",null,"Semi-dominant","PR domain containing 1, with ZNF domain ","Prdm1 ","Normal","Blimp-1, Blimp1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt ","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6334,"STAT6/Blimp424","C57BL/6-Prdm1<tm1Nutt> Stat6<tm1Aki>",null,"Semi-dominant","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034 ","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10"]
[6337,"Tbx5 BAC","Tbx5 BAC Transgenic",{"$nulls":3},"  Tbx5    ",{"$nulls":35},"Phenotype does not differ from a wildtype of the same genetic background.",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6340,"VAV-bcl-473","VAV-bcl-473",{"$nulls":3},"  bcl2       Bim    ",{"$nulls":35},"Vavbcl69: Excess B cells throughout life.  Develop glomerulonephritis, lymphoma and plasmacytoma Enlarged spleens Lymphadenopathy (more white blood cells), larger (2-3fold) spleen and lymph nodes  ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6342,"MYC10/200VT","vav-Myc 10 x vav-Myc/CTTG-PU1.200",{"$nulls":3}," vav-myc     PU1       TTA    ",{"$nulls":35},"Tumour development  T/+ mice develop thymoma or sub-cutaneous tumours (hystiocytic sarcoma) with a median onset of 41 weeks. T/T mice develop thymoma with a median onset of 13 weeks.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4531,"TNAP-Cre","C.B6-Alpl<tm1(cre)Nagy>/AnuApb",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase","TNAP",{"$nulls":10},"Embryonic Lethal",null,"Balb/c x C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","8",null,null,"No","2009-02-27","Cryopreserved sperm"]
[5174,"Nehmet ; Maat ; ENU15China:011a","C57BL/6JAnu-Cd4<maat>/AnuApb","C57BL/6JAnu-Cd4<maat>/AnuApb","Recessive","CD4 antigen","Cd4","Unknown","L3T4, Ly-4","MGI:88335","Maat","Cd4<Maat>","MGI:4819382","6","ENSMUSG00000023274","ENSMUST00000024044","Cd4-001",{"$nulls":7},"124816702","8",null,null,"GAGGACTGGGACCCTCACGACTACTCTCCTTGTCCCTGGGCAGCGCCAGGCAGCACGAAT","Yes",{"$nulls":12},"Low CD4 expression and CD4<+> T cell numbers.High CD8<+> T cell numbers",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-07-08","Cryopreserved sperm"]
[6350,"NPYGFP","B6.FVB-Tg(Npy-hrGFP)1LOWl/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Bradford B Lowell","Npy promoter",{"$nulls":10},"No abnormal phenotype detected:*Hemizygotes are viable and fertile.*When exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Npy gene.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[61,"PieBaldSeizures","ENU3strain:PieBaldSeizures",null,"Recessive",null,null,"Unknown",{"$nulls":5},"16",{"$nulls":15},"Yes",{"$nulls":12},"Mostly white coat with small black flecks and mottles (ie piebald). Eyes are black. Mice also show very subtle shaking/trembling but are otherwise healthy. Defect in melanisation. Seizures were seen in C57BL/6 background.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7",null,"No","2006-02-06","Cryopreserved sperm"]
[5714,"CYP/FGF9",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4080,null,"ENU6PH:078",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm"]
[6944,"ENU19 WT:019:b:B6:G3","ANU:ENU19WT:019:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4081,null,"ENU6PH:094",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm"]
[1362,"IL21RΔ","C57BL/6.129-IL21r<tm1Wjl>",null,"Recessive","interleukin 21 receptor","Il21r","Nil","IL-21R","MGI:1890475","targeted mutation 1, Warren J Leonard","Il21r<tm1Wjl>","MGI:2446509","7",{"$nulls":15},"No",{"$nulls":12},"Although mice deficient in the receptor for IL-21 (IL-21R) have normal lymphoid development, after immunization, these animals have higher production of the immunoglobulin IgE, but lower IgG1, than wild-type animals.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22"]
[6388,"ML5TG","C57BL/6-Tg(ML5sHEL)5Ccg/AnuAusb","C57BL/6-Tg(ML5sHEL)5Ccg/AnuAusb","Dominant",{"$nulls":25},"transgene insertion 5, Christopher C Goodnow","mouse metallothionein I promoter",{"$nulls":10},"Abnormal B cell anergy:*Abnormally low levels of anti-hen egg lysozyme (HEL) antibodies are made in response to immunization with HEL.*50-fold lower levels of anti-HEL antibodies occur in response to immunization with HEL coupled with sheep red blood cells, which is a T cell-independent method of activating B cells.Abnormal circulating protein level:*Hen egg lysozyme (HEL) is found in circulation at a median level of 17.3 ng ml<-1>",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6945,"ENU19 WT:021:b:B6:G3","ANU:ENU19WT:021:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[7671,"ENU26:008:IL7R:B6:G5","C57BL/6NCrlAnu-Il7r<m1Anu>/AnuApb",null,"Recessive","interleukin 7 receptor","Il7r","Unknown","CD127, IL-7Ralpha, IL-7 receptor alpha chain","MGI:96562",{"$nulls":3},"15","ENSMUSG00000003882","ENSMUST00000003981","Il7r-201","166","300","T to G","ENSMUSE00000269798","2","56","Threonine to Proline",{"$nulls":4},"TGGAAGTGGATGGAAGTCAACATTTATTGACTTGTGCTTTTAATGACTCAGACATCAACAC",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-05-02","Cryopreserved sperm"]
[4082,null,"ENU7PMH:036",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm"]
[6186,"GP139A056","B6;129S1-Mpl<tm1Wsa>/Wehi",null,"Recessive","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, thrombopoietin receptor, TPO-R","MGI:97076","myeloproliferative leukemia virus oncogene; targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":28},"Thrombocytopenic but healthy.  Platelet deficiency and hematopoietic stem cell anomalies. Alexander et al. Deficiencies in progenitor cells of multiple hemopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. ",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6570,"R5Δ","R5Δ",null,"Recessive",null,"R5",{"$nulls":37},"SVEV","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[6283,"FB/MOF8dec","FVB.C-Myst1<tm1.1Avo>",null,"Recessive","MYST histone acetyltransferase 1","Myst1","Nil","2010203C02Rik, 5830450F21Rik, D7Ertd629e, KAT8, MOF","MGI:1915023","MYST histone acetyltransferase 1; targeted mutation 1.1, Anne K Voss ","Myst1<tm1.1Avo>","MGI:3810976","7",{"$nulls":28},"Complete embryonic lethality before somite formation:*Although embryos implant they cannot develop beyond the E4.5 blastocyst and die by E5.5.Abnormal trophectoderm morphology:*In culture, trophectoderm cells from E.5 embryos exhibit limited growth and spreading compared to wild-type cells.Inner cell mass apoptosis:*Apoptosis in the remnant inner cell masses is increased compared to in wild-type.Abnormal inner cell mass proliferation:*The inner cell mass fails to proliferate and does not form an inner cell mass outgrowth as do wild-type cells.Abnormal chromosome morphology:*Cells exhibit abnormal chromatin distribution that precedes caspase 3 activation.Increased mitotic index",null,"FVB x BALB/c","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4499,"This and That","ENU4AT:017 ",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-25","Cryopreserved sperm"]
[85,null,"Trembles",null,"Recessive",null,null,"Unknown",{"$nulls":5},"4",{"$nulls":15},"Yes",{"$nulls":12},"Non-progressive mild-moderate ataxia evident at weaning. Some affecteds have shaggy fur. Full histology as been requested by APN. Video available. Phenotype unique to this chromosome location",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[4087,null,"ENU8PH:139, Metabolic Obese 1",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"High percentage of body fat on a low fat diet",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[6875,"BRINP2 Targetted, DBC2 Targetted","B6.Cg-Brinp2<tm1Pib>/PibMarpApb",null,"Recessive","bone morphogenic protein/retinoic acid inducible neural-specific 2","Brinp2",null,"6430517E21Rik, Fam5b, mKIAA1747","MGI:2443333","bone morphogenic protein/retinoic acid inducible neural-specific 2; targeted mutation 1, Phillip I Bird","Brinp2<tm1Pib>","MGI:5604614","1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-23","Cryopreserved sperm"]
[640,"Gz alpha knockout","C.B6-Gnaz<tm1Iah>/AnuApb","C.B6-Gnaz<tm1Iah>/AnuApb","Dominant","guanine nucleotide binding protein, alpha z subunit","Gnaz","Nil","Gz","MGI:95780","targeted mutation 1, I A Hendry","Gnaz<tm1Iah>","MGI:3575007","10",{"$nulls":15},"No",{"$nulls":12},"Hypertolerant to morphine, show anxiety.In previously unexposed female homozygotes reduced analgesia at low morphine doses is seen, a similar but not significant effect was seen in males.With repeated morphine doses mutants develop tolerance faster than wild type mice.Morphine treated homozygotes are able to tolerate higher morphine doses compared to wild type mice (LD50 of 800 mg/kg compared to 700 mg/kg for wild type)however no significant difference in the serum levels of morphine or its metabolites is seenreproductive systemLitters from homozygous parents on the C57BL/6 background had increased mortality that was not seen in litters from heterozygous or mixed strain parentstouch/vibrissae.","Decreased sensitivity to xenobiotic induced morbidity/mortality: morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 750 mg/kg compared to 700 mg/kg for wild-type).Abnormal chemically-elicited antinociception: with repeated morphine doses heterozygotes develop tolerance faster than wild-type mice but not as quickly as homozygous mutants.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","20",null,null,"No","2007-04-25","Cryopreserved sperm"]
[5176,"APN 33 ; VG10452","C57BL/6N-Smcr7<tm1(KOMP)Vlcg>",null,"Recessive","Smith-Magenis syndrome chromosome region, candidate region","Smcr7",null,null,"2144199","Smith-Magenis syndrome chromosome region, candidate 7 homolog (human); targeted mutation 1, Velocigene","Smcr7<tm1(KOMP)Vlcg>","MGI:3808263","11",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6N","No","Unknown","Unknown","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-07-14","Cryopreserved sperm"]
[2367,"Mr Hankey ; ENU8CAT:005","B6;CB-Prkdc<hanky>/AnuApb","B6;CB-Prkdc<hanky>/AnuApb","Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","hankey","Prkdc<hanky>","MGI:4820716","16","ENSMUSG00000022672","ENSMUST00000023352","Prkdc-201","1634","1657","T to A","ENSMUSE00000282431","16","545","Leucine to STOP",{"$nulls":4},"AGGCTGTGACCAGATGGAGGATTTTATTTTAGGAGATGAAACATTTCTCTTTGTGAACTCC","Yes",{"$nulls":12},"Diarrhoea.Lymphopenia",null,"C57BL/6JAnu x CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[37,"Dwarf","C57BL/6JSfdAnu-Wars<tukku>/Apb",null,"Recessive","tryptophanyl-tRNA synthetase","Wars","Unknown","dwarf","MGI:104630","tukkuburko","Wars<tukku>","MGI:4819385","12","ENSMUSG00000021266","ENSMUST00000078788","Wars-201","89","220","T to C","ENSMUSE00000116158","2","30","Leucine to Proline",{"$nulls":4},"AGCTACTCAAGGGGAGCTCGTGAGGTCCCTCAAAGCTGGAAATGCACCAAAAGATGAGATT","Yes",{"$nulls":12},"Dwarfism; small at weaning/adult 60% of wt sib.Small to non-existant pituitary gland.Low IGF levels in serum.Phenotype unique to this chromosome location",null,null,"Yes","Unknown","Yes","Yes","Unknown","Yes","Yes","Good",null,"6","het x het","No","2006-02-06","Cryopreserved sperm"]
[1490,"CD40 -/-","B6.129-CD40<tm1Klk>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","CD40 antigen; targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":15},"Yes",{"$nulls":12},"Unknown.Phenotype on B6 background described but not for BALB/c background.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-03"]
[6344,"Mcl-1(33)/v-abl40","vavMcl-1(33)/B6.E� SV-v-abl 40 COPY",{"$nulls":3},"  Mcl1     E�vabl   ",{"$nulls":35},"vabl40 - Low incidences of plasmacytoma. Look out for dragging hind legs, enlarged spleen, enlarged menteric lymph nodes - tumours. Visually check.   1-2% will die at 20 weeks of age, 19-20% will die at 1 year. Mice die as a result of plasmcytoma. Mice will bear one of the following tumours: lymphoma, splenomegaly, messentary associated, abdominal, caecal, Peyer's Patches. They may also suffer from small bowel obstruction, intestinal haemorrhage, hind leg paralysis, intussusception,  Mcl-1 - Transgenics may have late onset haematopoietic tumours.  Expect onset of tumours from 2 months of age. Will mainly occur in mesenteric lymph node. Abdomen will look/feel enlarged.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2464,null,"B6.CBA-Tg(hGMCSF-2CK1)79/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GM-CSF","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm"]
[5017,null,"BALB/c-SM22/CNX 40 tg1 (N4)",null,"Dominant",{"$nulls":39},"3","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[1511,null,"C57BL/6-Tcra<tm1Mom> Tg(TcrLCMV)327Sdz/AnuApb",null,"Recessive","T-cell receptor alpha chain","Tcra","Unknown","Tcr alpha, Tcralpha","MGI:98553","targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":15},"Yes","transgene insertion 327, Birgit Ledermann",null,"High",{"$nulls":9},"T cell express T cell receptor specific for LCMV P14 protein.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-04","Cryopreserved sperm"]
[46,"Kenobi ; ENU5strain:045; ENU5WT:054 ","C57BL/6JSfdAnu-Cd79a<m1Anu>/AnuApb","C57BL/6JSfdAnu-Cd79a<m1Anu>/AnuApb","Recessive","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Nil","Cd79a, Ig alpha, Ig-alpha, Iga, Ly54, mb-1","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); mutation 1, The Australian National University","Cd79a<m1Anu>","MGI:5006856","7","ENSMUSG00000003379","ENSMUST00000003469","Cd79a-001","186","327","G to A","ENSMUSE00000199568","2","62","Tryptophan to STOP",{"$nulls":4},"AATGGCAGGAACCCTAATATCACATGGTGGTTCAGCCTTCAGTCTAACATCACATGGCCCC","Yes",{"$nulls":12},"Immune deficiency. Hypogammaglobulinemia. Absolutely no B cells or pre-B cells.",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2004-04-28","Cryopreserved sperm"]
[5002,"aFO8 aa262","FVB/N-Tg(Prm1-Pebp1)8Mkob/MarpApb",null,"Dominant",{"$nulls":25},"phosphatidylethanolamine binding protein 1","Protamine 1","low level expression",{"$nulls":11},"FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","0",null,null,"No","2010-02-22","Cryopreserved sperm"]
[5180,null,"ENU15CHINA:075b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"CD4:CD8 T cell ratio skew. Decreased CD4 population and increased CD8 population","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-07-19","Cryopreserved sperm"]
[4178,"APN4","B6;129-Rbbp4<Gt(AD0773)Wtsi>/MIMR",null,"Recessive","retinoblastoma binding protein 4","Rbbp4","Unknown","CAF-1 p48 subunit, mRbAp48","MGI:1194912","retinoblastoma binding protein 4; gene trap AD0773, Wellcome Trust Sanger Institute","Rbbp4<Gt(AD0773)Wtsi>","MGI:3863854","4",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1",null,"Chimera x C57BL/6","No","2008-12-18","Cryopreserved sperm"]
[4574,"FATT-129Sv/EvTac","129Sv-Lepr<FATT>/Apb",null,"Semi-dominant","Leptin Receptor","LepR","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, OB-RGRP, obese-like, obl, Obr","MGI:104993","FATT",null,null,"4",{"$nulls":15},"No",{"$nulls":12},"The homozygote mutant has juvenile obesity, florid diabetes. The adult is hypogonadal and does not breed, and had an increased body length (10-20%).","There is a slight change in adipose tissue distribution and liver weight but no other significant changes.","129Sv/EvTac","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-03-08","Cryopreserved sperm"]
[5718,"Dallaglio KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5719,"Dan Blackmore C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4730,null,"NOD.B6.Cg-H2<k> Tg(TLK2mHEL)2Ccg/AnuApb","NODB6.Cg-H2<k> Tg(TLK2mHEL)2Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid",{"$nulls":9},"Express low levels of membrane bound HEL in thyroid. Low serum levels of HEL detected.",null,"NOD.Cg-H2<k> x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2009-04-17","Cryopreserved sperm"]
[5010,"Zedd","FVB/n-Luciferase Tg1 (ASD069)",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[6947,"ENU19 WT:023:a:B6:G3","ANU:ENU19WT:023:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4434,null,"ENU7B6:011",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"3",null,"No","2009-02-17","Cryopreserved sperm"]
[4577,null,"NOD.129S7-H2<k> Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Nil","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k2 variant","H2<k2>","MGI:4936842","17","Abnormal immune system",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm"]
[4578,null,"PLJ.129S7-Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal immune system",null,"PLJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm"]
[6298,"Mcl-1flox/KO50/lckcre","C57BL/6-Mcl1<tm3Sjk> Trp53<tm1Tyj> Tg(Lck-cre)548Jxm",null,"Semi-dominant","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3",{"$nulls":16},"transgene insertion 548, Jamey Marth","mouse lck promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6298,"Mcl-1flox/KO50/lckcre","C57BL/6-Mcl1<tm3Sjk> Trp53<tm1Tyj> Tg(Lck-cre)548Jxm",null,"Semi-dominant","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11"]
[5251,"FHWMKA","B6.129-Fxn<tm1Mkn> Tg(FXN)CSars/Apb",null,"Recessive","Frataxin","Fxn",null,"Frda","MGI:1096879","frataxin; targeted mutation 1, Michel Koenig","Fxn<tm1Mkn>","MGI:2177162","19",{"$nulls":15},"No","Human FRATAXIN gene","FXN endogenous promoter",{"$nulls":10},"Homozygous FXN transgene: Normal.Homozygous Fxn knockout: embryonic lethal, but completely complemented by presence of FXN transgene.","Hemizygous FXN transgene: Normal.Heterozygous Fxn knockout: Normal.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16","Hemizygous FXN transgene and Homozygous Fxn knockout  X Hemizygous FXN transgene and Homozygous Fxn knockout","Yes","2010-10-20","Cryopreserved sperm"]
[5519,"17China 43b","C57BL/6JAnu-Ptprc<m1Anu>/Apb",null,"Dominant","protein tyrosine phosphatase, receptor type, C","Ptprc ","Reduced","B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","mutation 1, The Australian National University","Prtprc<m1Anu>",null,"1",{"$nulls":15},"No",{"$nulls":12},"Blood lymphopenia","Reduced expression of CD45","C57BL/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"3","Sib x sib","No","2011-06-07","Cryopreserved sperm"]
[5373,"NOD.SCID/BDC2.5","NOD.Cg-Prkdc<scid> Tg(TcraBDC2.5,TcrbBDC2.5)1Doi",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":16},"transgene insertion 1, Christophe Benoist",{"$nulls":12},"InsulitisIncreased activated T cell number","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[4775,"5AT142","ENU5AT:142",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[5374,"Hom.NOD.FADD51","NOD/Lt-Tg(Ins2-dnFADD)51Wehi",null,"Dominant",{"$nulls":25},"dominant negative Fas associated death domain protein","rat insulin promoter (Ins2) (RIP)","2 - 3 copies",{"$nulls":9},"Islets developed normally in these animals.β cells from the transgenic mice were resistant to killing via the Fas pathway in vitro.A reduced incidence of diabetes was found in mice with higher levels of dominant-negative FADD expression.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[4918,"CD9 -/-","B6.129-CD9<Bcx>/AusbApb",null,"Recessive","CD9 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<tm1Bcx>","MGI:2180795","6",{"$nulls":28},"Reduced female fertility: 40 - 50% of females fail to produce litters.Decreased litter size.Impaired fertilization: impaired sperm - egg fusion.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2009-10-20","Cryopreserved sperm"]
[6948,"ENU19 WT:025:b:B6:G3","ANU:ENU19WT:025:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4606,"mIMPα4delta","C57BL/6-Tg(EGFP-Kpna4 dominant negative) ",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"3",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","EGFP fused to dominant negative Kpna4","Protamine 1",{"$nulls":10},"Fertility maybe reduced.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[5020,"N4.WB6.Hep.516Kl/+","N4.WB6.Hep.516Kl/+",null,"Dominant",{"$nulls":39},"8","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[4603,"mIMPα2FL","C57BL/6-Tg(EGFP-Kpna2 full length) ",null,"Recessive","karyopherin (importin) alpha 2","Kpna2","Unknown","Importin alpha, m-importin, m-importin-alpha-P1, pendulin, Rch1","MGI:103561",{"$nulls":3},"11",{"$nulls":15},"Yes","EGFP fused to full length Kpna2","Protamine 1",{"$nulls":10},"Unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[3472,"CD11c-mOVA","C57BL/6-Tg(Itgax-mOVA)",null,"Dominant",{"$nulls":25},"membrane bound ovalbumin","CD11c (mouse) (Itgax)",{"$nulls":10},"Normal. Transgenic mice express membrane bound ovalbumin under the control of the CD11c promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[5492,"Ndfip - 2 (SV129 Background)","Ndfip - 2 (SV129 Background)",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Unknown",null,"129Sv","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-05-02","Cryopreserved sperm"]
[6810,"L12SLR1R","SJL.B6-L12SLR1R<C57BL/6>/MriApb",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"9","This allele confers normo-susceptibility to Plasmodium chabaudi compared to wildtype SJL.",null,"SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"Yes","2012-02-01","Cryopreserved sperm"]
[6950,"ENU19 WT:029:a:B6:G3","ANU:ENU19WT:029:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4520,null,"ENU8C:051",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[2780,"C57BL/6.Flii 2.1A","B6.C-Flii<tm1Hdc>/3AnuApb","B6.C-Flii<tm1Hdc>/3AnuApb","Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal","No obvious altered phenotype","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10","11","Het male x WT female","No","2008-02-16","Cryopreserved sperm"]
[5177,"17FOX 014 B6.129-Tg(FoxP3-GFP)","ENU17FOX:014 Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Reduced B cell population, visualised via flow cytometric analysisCells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-07-19","Cryopreserved sperm"]
[5177,"17FOX 014 B6.129-Tg(FoxP3-GFP)","ENU17FOX:014 Foxp3<tm2Ayr>",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown"]
[5784,"FGF9",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5788,"Floxed ErbB4 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4827,"6AT:022","ENU6AT:022",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[5117,"TH-GFP","C57BL/6-Tg(Th-EGFP)21-31Koba",null,"Dominant",{"$nulls":25},"transgene insertion 21-31, Kazuto Kobayashi","rat tyrosine hydroxylase gene","High, 10 copies",{"$nulls":9},"Strong GFP fluorescent signal is detected in typical catecholaminergic cell groups and in most dopaminergic neurons of the transgenic adult ventral midbrain. Embryonic expression begins in the dopaminergic neurons of the developing ventral midbrain around E11-E12, is dramatically reduced later in gestation, and gradually resumes postnatally.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-12"]
[4646,null,"MRL/MpJ-Icam<tmBay> Fas<lpr>/JMarpApb",null,"Recessive","intercellular adhesion molecule 1","Icam1","Nil","CD54, Icam-1, Ly-47, MALA-2, MGC:6195","MGI:96392","targeted mutation 1, Baylor College of Medicine","Icam1<tm1Bay>","MGI:1857183","9",{"$nulls":15},"Yes",{"$nulls":12},"MRL/MpJ-Fas(lpr) (Fas(lpr)) mice develop a rapidly fatal form of systemic autoimmune disease characterized by glomerulonephritis and vasculitis similar to severe cases of systemic lupus erythematosus in humans. ICAM-1 deficiency resulted in a striking improvement in the survival of Fas(lpr) mice (median +/- SEM survival of Fas(lpr) = 26 +/- 1.7 vs ICAM-1/Fas(lpr) = 47 +/- 2.4 wk, p < 0.0001) and the increased survival was associated with delayed elevations of blood urea nitrogen levels in the ICAM-1/Fas(lpr) mice. Histologic examination of the ICAM-1/Fas(lpr) mice revealed an overall reduction in glomerular disease and a significant reduction in vasculitis in the kidney, lung, skin, and salivary glands when compared with Fas(lpr).",null,"MRL/MpJ","Yes","No","Yes","Yes","No","Yes","No","Unknown","10",null,null,"No","2009-03-22","Cryopreserved sperm"]
[4646,null,"MRL/MpJ-Icam<tmBay> Fas<lpr>/JMarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","Unknown"]
[4698,null,"NOD.Cg-Tg(H2-Ea-Atp4b)1Wehi/WehiApb",null,"Dominant",{"$nulls":25},"ATPase, H+/K+ exchanging, beta polypeptide (Atp4b)","1.8-kb fragment encoding nucleotides -1,903 through -39 of the 5' flanking sequence of the MHC Class II gene, H2-Ea (k allele)",{"$nulls":12},"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[337,"C57BL/6J-Rag1<tm1>TgN(OT-I)","B6.129-Rag1<tm1Bal> Tg(TcraTcrb)1100Mjb",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, David Baltimore","Rag1<tm1Bal>","MGI:2448994","2",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-05"]
[6809,null,"SJL/Mrit-MRI47495",null,"Dominant","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Macrocytic anaemia","Macrocytic anaemia","SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-02-01","Cryopreserved sperm"]
[5118,"Ednrb-Kik","Un-Tg(Ednrb-Kik)",null,"Dominant",{"$nulls":25},"Kikume","Endothelin receptor B","Unknown",{"$nulls":9},"Ednrb-expressing cells in the gut express the photoconvertible protein, Kikume.",null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-05-12"]
[7063,"Momme D25","FVB/NJ-MommeD25 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D25","MommeD25","Unknown",{"$nulls":5},"3",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD25<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor","Tnf","Normal","DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha","MGI:104798","targeted mutation 2, Jonathon D Sedgwick","Tnf<tm2Jods>","MGI:3578747","17",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-20","Cryopreserved sperm"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Nil","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-alpha-R1, TNF-alphaR1, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1a<tm1Imx>","MGI:1857468","6"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1b","Tnfrsf1b","Nil","CD120b, p75, p75 TNFR, TNF-alphaR2, TNF-R-II, TNF-R2, TNF-R75, TNFalpha-R2, TNFBR, Tnfr-1, Tnfr2, TNFR80, TNFRII","MGI:1314883","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1b<tm1Imx>","MGI:1860087","4"]
[867,"B6.Fas-/-","B6;129P2-Fas<tm1Osa>/Apb","B6;129P2-Fas<tm1Osa>/Apb","Recessive","Fas (TNF receptor superfamily member)","Fas","Nil","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","targeted mutation 1, Osaka University Medical School","Fas<tm1Osa>","MGI:1861923","19",{"$nulls":15},"No",{"$nulls":12},"Premature death: 50% dead at about 5 months of ageAbnormal hepatocyte morphology: hepatocyte nuclear areas are variable and larger.Liver hyperplasia: * significantly heavier at 12 weeks of age and becomes 50-60% heavier by 16 weeks of age.* number of hepatocytes per each liver lobe is increasedimmune system.Increased leukocyte cell number: 20x higher than in controls, attributable to increased lymphocyte numbers.Increased lymphocyte cell number:* lymphocytosis; progressively accumulate abnromal T cells Thy1<+> B220<+> CD4<-> CD8<->.Increased B cell number: increase in the number of normal B cells.Abnormal T cell clonal deletion:* peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired.Abnormal lymph organ size.Enlarged spleen: spleen becomes progressively larger.Enlarged lymph nodes: lymph nodes become progressively larger.Lymphoid hyperplasia.Increased IgG level: 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age.Increased IgG1 level.Increased IgG2a level.Increased IgG2b level.Increased IgG3 level.Increased autoantibody level:* 50-500x higher levels of dsDNA and ssDNA autoantibodies at 16 weeks of age.Increased anti-double stranded DNA antibody level.Increased anti-single stranded DNA antibody level.Increased susceptibility to parasitic infection:* decreased survival after infection with Trypanosoma cruzi even though were able to clear parasites from blood and affected organs.Hypersensitivity:* occasional infiltration of lymphocytes into tissues such as the lungs and liver.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-25","Cryopreserved sperm"]
[4776,"TOMtg","FVB-Tg(tetO-MYC)1Lach/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Lewis A Chodosh","bacterial tetracycline-resistance operon",{"$nulls":10},"Normal",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4714,"Rolex/129","129-Hccs<tm1Tcc>/MarpApb",null,"X-linked","holocytochrome c synthetase","Hccs","Unknown",null,"MGI:106911","targeted mutation 1, Timothy C Cox","Hccs<tm1Tcc>","MGI:3826866","X",{"$nulls":15},"Yes",{"$nulls":12},"NormalHomozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm"]
[5181,"Mif -/- Fas<lpr>","MRL/MpJ.Cg-Fas<lpr> Mif<tm1Dvd>/MarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"MIF<–/–>MRL/lpr mice had significantly less proteinuria than MIF<+/+>MRL/lpr mice.Ab production in the MRL<lpr> mice was largely unaffected by MIF deficiency.No difference in the percentage of CD4<+> or CD8<+> T cells, B cells (CD3<->B220<+>), CD3<+>CD4<->CD8<->B220<+> double-negative T cells (DNTCs), or CD11b<+>CD11c<+> dendritic cells between MIF<+/+> and MIF<–/–>MRL<lpr> mice.MIF<–/–>MRL<lpr> mice were protected from crescentic glomeruli formation as compared to MRL<lpr> mice.MIF deficiency reduces renal macrophage recruitment and MCP-1 expression.",null,"MRL/MpJ","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-07-19","Cryopreserved sperm"]
[5181,"Mif -/- Fas<lpr>","MRL/MpJ.Cg-Fas<lpr> Mif<tm1Dvd>/MarpApb",null,"Recessive","macrophage migration inhibitory factor","Mif","Nil","Glif","MGI:96982","macrophage migration inhibitory factor; targeted mutation 1, John R David","Mif<tm1Dvd>","MGI:2176337","10",{"$nulls":15},"No"]
[6949,"ENU19 WT:026:a:B6:G3","ANU:ENU19WT:026:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[657,"transgenic line MBP-c-myc ","B6.129-Tg(Mbp-MYC*)/Apb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","exons 2 and 3 of the human c-myc gene","1.3Kb of the mouse myelin basic protein (Mbp)","very low",{"$nulls":9},"Mice exhibit a transient shivering phenotype over the period corresponding to the peak of central nervous system myelination (4 to 8 weeks postnatally). Thereafter, shivering decreases abruptly and mice go on to live a normal life-span and breed normally.","As for heterozygous, but more pronounced. Death between 4 and 8 weeks has been observed but is rare. ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent","38",null,"transgenic males mated to normal C57BL/6 females between about 7 to 15 weeks of age","No","2007-04-26","Cryopreserved sperm"]
[4846,"Pricilla","ENU6CAT:04",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[5113,"Joey-SCO","C57BL/6JAnu-Etv5<sco>/AnuMarpApb","C57BL/6JAnu-Etv5<sco>/AnuMarpApb","Recessive","ets variant gene 5","Etv5","Unknown","ERM","MGI:1096867","ets variant gene 5; sco","Etv5<sco>","MGI:5563470","16","ENSMUSG00000013089","ENSMUST00000079601","Etv5-202","1234","1414","A to T","ENSMUSE00000560895","12","412","Lysine to STOP",{"$nulls":4},"AAGAGGTTGCTCGCCGTTGGGGTATCCAGAAGAATCGGCCAGCCATGAACTATGACAAGCT","No",{"$nulls":12},"Sertoli cells only.Male infertility.Progressive loss of germ cells following the first wave of spermatogenesis.Germ cells appeared to be preferentially lost in a basal to apical direction from the seminiferous epithelium as detected in 7 week old testis.Reduced testis size, compared to WT, at 8 weeks of age.Etv5 mRNA levels 95% reduced compared to WT males.Etv5 mRNA is unstable.Reduced expression of Etv5 target genes Cxcr4 and Ccl9.Increased incidence of embryonic and perinatal lethality.Reduced body weight.Renal asymmetry.Polydactyly.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2010-05-10","Cryopreserved sperm"]
[4712,"T3RWT","B6.129-Tlr3<WT>",null,"Dominant","toll-like receptor 3","Tlr3","Unknown",null,"MGI:2156367",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Wild-type strain used as control for Tlr3 knockout, APB ID#630",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm"]
[3383,"K14-Grhl3","B6-Tg(K14-Grhl3) ",null,"Dominant",{"$nulls":25},"grainyhead-like 3 (Drosophila) (Grhl3)","keratin 14 (K14)",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"transgenic x transgenic","No","2008-07-09","Cryopreserved sperm"]
[4475,null,"Brooke",null,"Dominant",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm"]
[4845,null,"ENU6AT:53",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[4721,"TGM2 floxed","C57BL/6-Tgm2<tm1Rmgr>/Apb",null,"Recessive","transglutaminase 2, C polypeptide","Tgm2","Normal","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 1, Robert M Graham","Tgm2<tm1Rmgr>","MGI:3525256","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal - no phenotypic analysis * mice were only used to generate the null allele",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm"]
[5723,"DCCKanga",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5724,"Dcckanga/Tomato/Satb2Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5456,"ENU14Ch 036b; ENU14China:036b","C57BL/6JAnu-Cd22<m1Anu>/AnuApb","C57BL/6JAnu-Cd22<m1Anu>/AnuApb","Recessive","CD22 antigen","Cd22","Reduced","Lyb-8, Lyb8","MGI:88322","CD22 antigen; mutation 1, Australian National University","Cd22<m1Anu>","MGI:5009050","7","ENSMUSG00000030577","ENSMUST00000019248","Cd22-201","1536","2116","T to A","ENSMUSE00000359124","7","511","Cysteine to STOP",{"$nulls":4},"GTCAGCTGTGCTGCCTGCAACCACAAGTGTTCGTGGGCCCTCCCTGTCATCCTGAATGTCC","Yes",{"$nulls":12},"Block in B cell maturation and reduced number of B cells in peripheral blood.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm"]
[108,"Alison2 ; AL3","C57BL/6JSfdAnu-Tg(AlsHEL)3Ccg/AnuApb","C57BL/6JSfdAnu-Tg(AlsHEL)3Ccg/AnuApb","Dominant",{"$nulls":25},"soluble Hen Egg Lysozyme (HEL)","liver specific albumin","high",{"$nulls":9},"High ubiquitous expression of soluble Hen Egg Lysozyme (sHEL). Females express approximately 2-fold more sHEL than males of this strain.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","Hom xHom","No","2006-02-06","Cryopreserved sperm"]
[4803,"Mal ; ENU8BAT:012","B6(Cg);CBA-Rabl2a<mot>/AnuApb",null,"Recessive","RAB, member of RAS oncogene family-like 2A","Rabl2a",null,null,"MGI:1915958","RAB, member of RAS oncogene family-like 2; mot","Rabl2<mot>","MGI:5469381","15","ENSMUSG00000022621","ENSMUST00000023294","Rabl2a-201","218","311","A to G","ENSMUSE00000128937","5","73","Aspartic acid to Glycine",{"$nulls":4},"CACAGTAGACGGCAAGACGATCCTTGTGGACTTCTGGGATACAGCAGGCCAGGAGCGGTTC","Yes",{"$nulls":12},"Male InfertilityDecreased testis weightOligozoospermiaShort sperm flagellumAsthenozoospermia:• low total motility and minimal progressive motility• however, ultrastructure is normal",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[2767,"BALB/c.Flii<-/-> FLII<c110H8/c110H8> ; FICR","BALB/c-Flii<tm1Hdc> Tg(FLII)1Hdc/AnuApb","BALB/c-Flii<tm1Hdc> Tg(FLII)1Hdc","Recessive","flightless I homolog (Drosophila)","Flii","Unknown","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes","transgene insertion 1, Hugh D Campbell","human flightless promoter",{"$nulls":10},"Embryonic lethal phenotype of FLii knockout is rescued by human FLII transgene. Ubiquitous expression of human Flightless gene.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"FLii<-/-> FLII<c110H8/c110H8> x FLii<-/-> FLII<c110H8/c110H8>","No","2008-02-15","Cryopreserved sperm"]
[5725,"DccKangC57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4705,"NOD-HIPCre","NOD-Tg(INS-cre)2Rms/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Robyn M Slattery","human insulin promoter","beta islet cells",{"$nulls":9},"The human insulin promoter (INS) drives cre expression in beta islet cells. Resistance to development of diabetes and hyperglycemia",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[5184,"Vincent ; KRN 14 Vincent B6 F2","KRN:014 Vincent B6 F2",null,"Recessive","glutamate receptor, ionotropic, kainate 4","Grik4","Unknown","6330551K01Rik, GluRgamma1, KA-1, KA1 ","MGI:95817",{"$nulls":3},"9",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-07-26","Cryopreserved sperm"]
[7703,"ENU29:G3","ANU:ENU29:G3",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2014-06-17","Cryopreserved sperm"]
[4731,"Rama","C57BL/6-Tg(H2-K-sHELdimer)/Apb",null,"Dominant",{"$nulls":25},"soluble Hen Egg Lysozyme dimeric molecule","H-2K<b>","Low",{"$nulls":9},"Low serum expression of dimeric soluble HEL.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-17"]
[7514,"QSi5","Quackenbush Swiss i5",null,"Dominant",{"$nulls":37},"Outbred strain derived from Quackenbusg Swiss.Highly fecund - average litter size 13.4Large litter size.Shorter period between litters.Septum primum or flap valve length (FVL) - long compared to 129 - 1.13mm v 0.6mmMilk yield 3x greater than CBA.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-28","Embryo"]
[109,"Andrew2 ; ML4","C57BL/6JSfdAnu-Tg(ML4sHEL)4Ccg/AnuApb","C57BL/6JSfdAnu-Tg(ML4sHEL)4Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow ; soluble HEL (hen egg lysozyme)","zinc inducible mouse metallothionein I","High",{"$nulls":9},"Mice homozygous for the TgN(ML5sHEL)5Ccg transgene express a soluble form of hen egg lysozyme.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"10","sib x sib","No","2006-02-06","Cryopreserved sperm"]
[4737,null,"ENU8C:060",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","1",null,null,"No","2009-04-19","Cryopreserved sperm"]
[7515,"QSi5","Quackenbush Swiss i5",null,"Dominant",{"$nulls":37},"Highly fecund - large litter sizeShorter time between littersImproved lactation - compared to CBA. Higher milk yield, more efficient milk production.Septum primum or flap valve length (FVL) longer compared to 129T2 - 1.11 mm v 0.6mm.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-28","Embryo"]
[128,"Deirdre ; IgMdE","C57BL/6JSfdAnu-Tg(IgMδEHEL)Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IgMδEHEL)Ccg/AnuApb","Dominant",{"$nulls":25},"chimeric anti-Hen Egg Lysozyme Ig molecule, the extracellular spacer of IgM was substituted for IgD.",null,"H and L genes are cointegrated",{"$nulls":9},"B cells express chimeric IgM/D molecule with affinity for Hen Egg Lysozyme",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"10","sib x sib","No","2006-02-06","Cryopreserved sperm"]
[5459,"ENU16Ch:017a, Lyn<T410A>","C57BL/6JAnu-Lyn<m1Anu>/AnuApb","C57BL/6JAnu-Lyn<m1Anu>/AnuApb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog  ","Lyn","Unknown","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; mutation 1, Australian Phenomics Facility","Lyn<m1Apb>","MGI:5501039","4","ENSMUSG00000042228","ENSMUST00000041377","Lyn-001","1228","1483","A to G","ENSMUSE00000605548","12","410","Threonine to Alanine",{"$nulls":4},"GGGAAGGTGCGAAGTTCCCTATCAAGTGGACAGCTCCAGAGGCCATCAACTTCGGCTGCTT","No",{"$nulls":12},"Very low B cells numbers but High IgM<+>IgD<-> cells.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm"]
[5631,"B6.129x1BAX",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5632,"B612954 PKd",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6356,"KRAS2f","B6.129-Kras<tm4Tyj>/Ausb",null,"Semi-dominant","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","Kras",null,"K-ras, Ki-ras, Kras-2, Kras2 ","MGI:96680 ","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks","Kras<tm4Tyj>","MGI:2429948","6",{"$nulls":28},"Increased lung tumor incidence:*Treatment with adenoviral Cre to induce oncogenic Kras expression results in lung tumor development, but causes a lower tumor burden and decreased overall tumor area compared to induced mutants on a Spry2-null background.",null,"B6/129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","H2A histone family, member B2","H2afb2","Nil","EG624153, H2A.Bbd4, H2afb2-ps","MGI:3644980",{"$nulls":3},"X",{"$nulls":28},"Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","FVB/NJArc","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"het to wt; homo to wt; homo to homo","No","2014-06-18","Cryopreserved sperm"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","H2A histone family, member B3","H2afb3",null,"EG624957, H2A.Bbd3, H2afb3-ps","MGI:3644875",{"$nulls":3},"X"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","predicted pseudogene 14920","Gm14920",null,"ENSMUSG00000067441, H2A.Bbd1","MGI:3642445",{"$nulls":3},"X"]
[5740,"DTA",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5741,"E2F7-/- (295/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7673,"Solox Low x AR 2-/-","B6;CBA-Ifnar2<tm1Pjh> Tg(sIfnar2)Pjh/MarpApb",null,"Recessive","interferon (alpha and beta) receptor 2","Ifnar2","Nil","Ifnar-2 ","MGI:1098243 ","interferon (alpha and beta) receptor 2; targeted mutation 1, Paul J Hertzog","Ifnar2<tm1Pjh>","MGI:2680693","Unknown",{"$nulls":16},"interferon (alpha and beta) soluble receptor 2 low expression ",null,"Low",{"$nulls":9},"Unknown","Unknown","C57BL/6 (tbc)","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2014-05-07","Cryopreserved sperm"]
[3340,"C57BL/6 Tg(IL5)C2","B6.CBACa-Tg(CD2-Il5)5C2Ldt/Apb [cc]","B6.CBACa-Tg(CD2-Il5)5C2Ldt/Apb [cc]","Dominant",{"$nulls":25},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia. Northern blot analysis identified 11,5 mRNA in the thymus, Peyer's patches, and subcutaneous (pooled inguinal and axillary) lymph nodes. No IL5 mRNA was detected in liver, heart, brain, or skeletal muscle tissues from transgenics, nor in any tissues from normal littermates. Do not maintain as homozygotes. While this is apparently possible, survival of homozygotes likely to be lower.","C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","20",null,"Tg male wild type female","No","2008-06-20","Cryopreserved sperm"]
[7277,"SJL.RIIa Tg","SJL.Fcgr2a Tg","HOGA","Semi-dominant","Fcgamma r2a","FcgR2a","Normal",{"$nulls":5},"Unknown",{"$nulls":16},"human FcyR2a","human FcyR2a","normal",{"$nulls":9},"spontaneous arthritis","not known","SJL","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","12",null,null,"Yes","2013-02-15","Cryopreserved sperm"]
[4736,"Anasette","ENU5AT:140 ",null,"Recessive",null,null,"Unknown",null,null,"Anasette",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2009-04-19","Cryopreserved sperm"]
[4576,null,"B6.129S7-Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":12},"abnormal immune cell physiology (J:99347)splenocytes proliferate against the antigen and a mitogen more vigorously than those from wild-typeincreased interferon-gamma secretion (J:99347)stimulation of splenocytes with an antigen or a mitogen induces a higher production of IFN-gamma than in wild-typeincreased interleukin-6 secretion (J:99347)stimulation of splenocytes with an antigen induces a higher production of IL-4, IL-6, IL-13 and IFN-gamma than in wild-typestimulation of splenocytes with a mitogen induces a higher production of IL-13increased susceptibility to experimental autoimmune uveoretinitis (J:99347)exhibit increased incidence and severity of induced experimental autoimmune uveoretinitis compared to wild-type (59.3% vs. 40% of wild-type)upon uveoretinitis induction, see a significant infiltration of eosinophils into the eyes compared to wild-typeliver/biliary systemliver/biliary system phenotype (J:120559)mice show no liver injury on treatment with HBsAg-specific Th1 cells and HBsAgtumorigenesisaltered tumor susceptibility (J:138466)tumor growth in tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells is minimally delayed, and develop progressive disease",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm"]
[18,"Androida","ENU5:028 ",null,"Recessive",null,null,"Unknown",null,null,"Androida",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2006-08-19","Cryopreserved sperm"]
[2781,"C57BL/6.Flii 1.4A","B6.C-Flii<tm1Hdc>/2AnuApb","B6.C-Flii<tm1Hdc>/2AnuApb","Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality at implantation: no embryos are recovered after E5.5; embryos develop normally until cellularization, the development arrests before completion of gastrulation blastocysts initiate uterine implantation but embryos fail to develop.embryonic growth arrest: development arrests during gastrulation","Enhanced wound healing: 3 days after a 1 cm full-thickness incision was made in the dorsal skin, surface wound area measurements show smaller, more contracted wounds than in wild-type mice. Length of neoepidermis is significantly greater in mutant animals, and percentage or re-epithelialization of wounds is greater at 5 days after wounding. By day 7, healing is comparable in mutants and wild-type","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10","11",null,"No","2008-02-16","Cryopreserved sperm"]
[4468,"HB9-GFP","129-Tg(Mnx1-GFP)1Slp/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Samuel L Pfaff","Mnx1",{"$nulls":10},"Enhanced Green Fluorescent protein highlights motoneurons in the spinal cord.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"sib x sib","Yes","2009-02-22","Cryopreserved sperm"]
[4732,null,"B6;B10Br;129-Cblb<tm1Pngr> Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":11},"T cell signalling defect",null,"C57BL/6 x C57BL/10.Br x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","1","2",null,"No","2009-04-19","Cryopreserved sperm"]
[9,"Anaconda","ENU4:006 ",null,"Recessive",null,null,"Unknown",null,null,"Anaconda",null,null,"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2004-04-20","Cryopreserved sperm"]
[16,"Anaya","ENU5:134 ",null,"Recessive",null,null,"Nil",null,null,"Anaya",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Phenotypic screen= positive for anti-nuclear antibodies",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2",null,null,"No","2004-04-20","Cryopreserved sperm"]
[5458,"ENU16China:051a ; Berty","C57BL/6JAnu-Prkdc<berty>/AnuApb","C57BL/6JAnu-Prkdc<berty>/AnuApb","Recessive","protein kinase, DNA activated, catalytic polypeptide  ","Prkdc","Reduced","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","rotein kinase, DNA activated, catalytic polypeptide; berty","Prkdc<berty>","MGI:5009121","16","ENSMUSG00000022672","ENSMUST00000023352","Prkdc-201","10326","10349","T to A","ENSMUSE00000129337","73","3442","Tyrosine to STOP",{"$nulls":4},"CAGAAGACAAGTGCAGAAATGGAAGCATATCCAGCACTTGTGGTGGAAAAAATGCTGAGAG","Yes",{"$nulls":12},"No B or T cells.",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","Yes","Poor",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm"]
[7517,"HA-TetO","C57BL/6-Tg(tetO-CYP19A1)2/MarpApb",null,"Dominant",{"$nulls":25},"Human Aromatase ; human cytochrome P450, family 19, subfamily a, polypeptide 1","TetO",{"$nulls":10},"Normal; no phenotype","Normal; no phenotype","C57BL/6J","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-11-29","Cryopreserved sperm"]
[5743,"E2F7/E2F8 floxed -/- (339/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5742,"E2F7/E2F8 flox-/- x K14Cre.FVB ?????",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5744,"E2F8 flox-/- x K14Cre.FVB (339/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6315,"OT-II/Puma/Bim ","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)425Cbn",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":13},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6315,"OT-II/Puma/Bim ","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)425Cbn",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519 ","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2"]
[6703,"Gt3","B6.129-Gtf2ird1<tm1Hrd>/Ausb",null,"Recessive","general transcription factor II I repeat domain-containing 1 ","Gtf2ird1","Nil","Alb-c-myc line 166.8, Alb/c-myc line 166.8, BEN, binding factor for early enhancer, c-myc line 166.8, Cream1, ESTM9, GTF3, MusTRD1, Tg(Alb1-Myc)166.8Sst, WBSCR11","MGI:1861942","general transcription factor II I repeat domain-containing 1; targeted mutation 1, Edna Hardeman","Gtf2ird1<tm1Hrd>","MGI:4454555","5",{"$nulls":28},"Impaired coordinationAbnormal nervous system physiology:*Mice exhibit evidence of altered GABAergic neuronal function compared with wild-type mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[3385,"Histamine receptor type 2 -/- ","B6.129P2-Hrh2<tm1Wtn>","B6.129P2-Hrh2<tm1Wtn>","Recessive","histamine receptor H2","Hrh2","Nil",null,"MGI:108482","histamine receptor H2; targeted mutation 1, Takeshi Watanabe","Hrh2<tm1Wtn>","MGI:2182949","13",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit enlarged folds in gastric mucosa, elevated serum gastrin levels, increased numbers of parietal and enterochromaffin-like cells, and lack of secretion of gastric acid in response to histamine or gastrin.Abnormal gastric mucosa morphology:* enterochromaffin-like (ECL) cells are increased in number and are found not only in the basal region, but also in the neck region and isthmus.* increase in H+, K+-ATPase negative cells in the isthmus and neck region.* histamine content in the gastric mucosa is elevated.* young mice (4 weeks old) in which hypertrophy of the oxyntic mucosa is not yet seen, exhibit a significant increase in cell proliferation in the mucosa.Abnormal gastric parietal cell morphology: parietal cells are increased in number, are smaller and contain enlarged secretory canaliculi with a lower density of microvilli and few typical tubulovesicles in the narrow cytoplasm.Increased thickness of gastric mucosa:* thickness of the oxyntic mucosa in the glandular region is increased in 16-week old mutants resulting in the formation of enlarged gastric folds.* change in mucosal thickness is most prominent in the isthmus and neck region.Decreased digestive secretion: induction of gastric acid secretion by histamine or gastrin is completely abolished, however carbachol still induced secretion.Abnormal stomach pH: basal gastric pH is normal, however elevation of gastric pH by administration of an Hrh2 antagonist, famotidine, is not observed.Increased circulating gastrin level: 12- to 18-week old mutants exhibit elevated serum gastrin levels (hypergastrinemia).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Brother x sister","No","2008-07-09","Cryopreserved sperm"]
[5222,"C57.Lyn-/-uMT-/-","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Nil","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"No",{"$nulls":12},"Mice are B cell deficient, and do not develop autoimmune disease characteristics of lyn -/- mice.","Not Studied","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-09-29","Cryopreserved sperm"]
[5222,"C57.Lyn-/-uMT-/-","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","Recessive","immunoglobulin heavy constant mu","Ighm",null,"BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","immunoglobulin heavy chain 6 (heavy chain of IgM); targeted mutation 1, University of Cologne","Ighm<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"No"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, CD45 antigen, Cd45, Ly-5, Lyt-4, T200, lymphocyte antigen 5","MGI:97810",null,"Ptprc<a>",null,"1",{"$nulls":15},"Yes","transgene insertion 327, Birgit Ledermann",null,"High",{"$nulls":11},"C57BL/6 x SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-11"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","peptidase C","Pepc","Unknown","Dip-1, Pep-3, Pep3","MGI:97541",null,"Pepc<b>",null,"1"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","T-cell receptor alpha chain","Tcra","Nil","Tcr alpha, Tcralpha","MGI:98553","T-cell receptor alpha chain; targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14"]
[258,null,"C57BL/6-Dpp4<tm1>",null,"Recessive","dipeptidylpeptidase 4","Dpp4","Nil","Cd26, Dpp-4, THAM","MGI:94919","targeted mutation 1, Nicolai Wagtmann","Dpp4<tm1Nwa>","MGI:2150161","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-30"]
[238,"MLR39","FVB/N-Tg(Cryaa-cre)39Mlr/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 39, Mike Robinson","aA-crystallin with tyrosinase cassette",{"$nulls":10},"Nil.  Mice express Cre in lens fibres with very little ectopic expression elsewhere",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm"]
[6951,"ENU19 WT:030:a:B6:G3","ANU:ENU19WT:030:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[7519,"QSi5 - black","Quackenbush Swiss i5 - black",null,"Dominant",{"$nulls":37},"Superior fecundity. Large litter size even after 50 generations.Mean length of the septum primum or flap valve length (FVL) is linger in QSI5 mice compared to 129T2 - 1.13mm compared to 0.60mm - the mean length of the septum primum or flap valve length (FVL) is strongly inversely correlated with patent foramen ovale (PFO) incidence.Increased lactation.More efficient milk production.Increased platelet count: QSi5 was found to have a mean platelet count of 1062 × 109/L (SD = 8.2 × 109/L, n = 16) versus that of 581 × 109/L (SD = 79 × 109/L, n = 23) in CBA mice.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo"]
[5748,"EKLF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5749,"EKLF/GKLF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4098,null,"KRN:156",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model. Candidate gene position likely to be Chr 3 or 12.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"5",null,"No","2008-12-04","Cryopreserved sperm"]
[4605,"mIMPα4FL (mid level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)mid",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","mid level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[17,"Andrea","ENU4strain:AT007",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Homogeneous anti-nuclear antibodies. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2004-04-20","Cryopreserved sperm"]
[5347,"B6.hCD4","C57BL/6-Tg(Cd4-CD4)2362Litt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":10},"CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","24",null,null,"No","2010-12-15","Cryopreserved sperm"]
[4716,null,"129-Shh<tm1Chg>/AnuApb",null,"Recessive","sonic hedgehog","Shh","Unknown","Hhg1, Hx, Hxl3, M100081","MGI:98297","targeted mutation 1, Chin Chiang","Shh<tm1Chg>","MGI:1857796","5",{"$nulls":15},"Yes",{"$nulls":12},"Perinatal Lethality, most die just before birth. abnormal dorsal-ventral axis patterning: indistinct midline at E8.5. Notochord degeneration: rostral-to-caudal loss of notochord tissue. Decreased brain size: abnormal forebrain morphology, ventral forebrain structures are lost. Abnormal diencephalon morphology: most of the diencephalon as an identifiable structure is absent. Abnormal telencephalon morphology: the bilateral lobes of the telencephalon are fused to form a single midline structure.  Abnormal long bone morphology: absence or fusion of the paired distal limb bones. Abnormal humerus morphology: have a bony extension of the humerus in the forelimb. Absent fibula:the fibula is absent in the hindlimb. Absent tibia: the tibia is absent in the hindlimb. Abnormal axial skeleton morphology: most sclerotomal derivatives are absent. Abnormal craniofacial bone morphology: craniofacial bones are severely affected and almost entirely absent. Decreased rib number: most of the ribs are absent, with only 5-6 rib cartilages remaining. Absent vertebrae: most sclerotomal derivatives including the entire vertebral column are absent, with only 5-6 rib cartilages remaining. Absent cartilage: cartilage is absent at the elbow joint.  Abnormal optic vesicle formation: optic vesicles are fused at the midline at E9.5, the optic stalks are deficient or absent, and there is no invagination to form the double-layered optic cups",null,"129SvEv","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Het x 129SvEv","No","2009-04-08","Cryopreserved sperm"]
[4717,"SmoTgR","C57BL/6-Tg(CMV-RFP/Smo)/MarpApb",null,"Dominant",{"$nulls":25},"red fluorescent protein tagged to Smoothened","cytomegalovirus (CMV)",{"$nulls":10},"Animals express red fluorescent protein, are viable and healthy.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","15","2","Mate positive RFP mice with wild type C57BL/6","No","2009-04-08","Cryopreserved sperm"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)","Csf2rb1","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, C Glenn Begley","Csf2rb<tm1Cgb>","MGI:2181245","15",{"$nulls":15},"Yes","colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)",null,"High",{"$nulls":9},"None detected","Normal","NOD/SCID","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"Matings of 2 transgenic non-sibling mice","Yes","2009-10-22","Cryopreserved sperm"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc",null,"DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16"]
[5346,"SS-01 ; Vegfd 2.2.36 (SS-01)","B6;129S1/Sv-Figf<tm1Mach>/Apb",null,"X-linked","c-fos induced growth factor","Figf","Nil","VEGF-D, Vegfd","MGI:108037","c-fos induced growth factor; targeted mutation 1, Marc G Achen","Figf<tm1Mach>","MGI:3576785","X",{"$nulls":28},"No abnormal phenotype detected: homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.Mice have reduced numbers of lymphatic vessels in lungs.","Normal","129S1/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","0",null,null,"No","2010-12-15","Cryopreserved sperm"]
[7,"Alberta","C57BL/6JSfdAnu-Lepr<brta>/AnuApb","C57BL/6JSfdAnu-Lepr<brta>/AnuApb","Recessive","leptin receptor","LepR","Unknown","LEPROT, leptin receptor gene-related protein, OB-RGRP, obese-like, obl, Obr","MGI:104993","alberta","Lepr<brta>","MGI:3847119","4","ENSMUSG00000057722","ENSMUST00000037552","Lepr-001",{"$nulls":7},"101768248","10",null,null,"ACCAACGTGTGTCCTTCCTGACTCCGTAGGTACGTCAGACTATATTATGTATTTTCCTTA","Yes",{"$nulls":12},"Homozygotes develop severe obesity evident by 4-8weeks. 50% develop diabetes by 6 weeks of age.Homozygotes don't breed",null,"C57BL/6JSfdAnu","Yes","No","Yes","Yes","No","Yes","Yes","Good",null,"9",null,"No","2006-02-06","Cryopreserved sperm"]
[7065,"Momme D41","FVB/NJ-MommeD41 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D41","MommeD41",{"$nulls":6},"16",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD41<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24"]
[5224,"BALB.Lyn up/up STAT6 knockout mice; BALB.Lyn-Y508FSTAT6 -/-","BALB/c-Lyn<tm1Mhi> Stat6<tm1Aki>/Apb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Reduced","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Margaret Hibbs","Lyn<tm1Mhi>","MGI:2157016","4",{"$nulls":28},"Not well defined","Not defined","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-01","Cryopreserved sperm"]
[5224,"BALB.Lyn up/up STAT6 knockout mice; BALB.Lyn-Y508FSTAT6 -/-","BALB/c-Lyn<tm1Mhi> Stat6<tm1Aki>/Apb",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No"]
[3401,"IL11R KO","B6.129-Il11ra1<tm1Wehi>/Wehi",null,"Recessive","interleukin 11 receptor, alpha chain 1","Il11ra1","Nil","Il-11ra, Il-11ra-alpha, Il11ra, NR1","MGI:107426","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Il11ra1<tm1Wehi>","MGI:2177778","4",{"$nulls":15},"No",{"$nulls":12},"Normal haemopoeisis. Female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization. A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-11 receptor alpha chain in the developing decidual cells. In both male and female IL-11Ralpha1-/- mice, trabecular bone volume was significantly higher than that of wildtype controls. This was associated with low bone resorption and low bone formation, and the low osteoclast number generated by IL-11Ralpha1-/- precursors was reproduced in ex vivo cultures, whereas elevated osteoblast generation was not.Embryonic lethality during organogenesis:* intercrosses of heterozygotes produce viable homozygous offspring at the expected Mendelian ratios.* however, embryos developing in homozygous mutant mothers appear necrotic at >7.5 dpc, with rare instances (<1%) of intact embryos detected at 9.5 dpc, and no live embryos found after 10.5 dpc.* notably, 2.5 dpc mutant embryos survive normally when transferred in foster uteri, whereas wild-type embryos fail to do so in uteri of mutant mice.Impaired embryo implantation:* at 4.5-7.5 dpc, homozygotes display a normal number of implantation sites relative to wild-type mice.* however, mutants show reduced capillary permeability and blood flow in the uterine vascular bed at the site of blastocyst apposition.Abnormal placenta development:* in most cases, embryos surviving in 9.5 dpc mutant uteri contain fibrinoid material and inflammatory cells in the space normally occupied by the placenta.* in a few cases, embryos surviving in 9.5 dpc mutant uteri display fetal components of the chorioallantoic placenta; however, the decidua basalis is entirely absent, being replaced by multiple layers of trophoblast giant cells, while the decidua capsularis is present but significantly thinner.Abnormal decidualization:* at 4.5 dpc, uteri of pregnant homozygotes display a reduced secondary decidual response to the implanting blastocystat 5.5-7.5 dpc, mutant deciduae are significantly smaller, displaying hemorrhage in the uterine lumen, disruption of the antimesometrium, and overgrowth of giant trophoblast cells in the mesometrial portion of the deciduum.* notably, pseudopregnant homozygotes show reduced deciduoma formation in response to an artificial (oil) stimulus, albeit with partial preservation of mesometrial decidual tissue.Increased trophoblast giant cell number: pregnant homozygotes exhibit a significantly increased number of secondary trophoblast giant cells in the mutant decidua.","Normal","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-07-13"]
[3946,"MommeD5","FVB/NJ-Hdac1<MommeD5>/Apb","FVB/NJ-Hdac1<MommeD5>/Apb","Semi-dominant","histone deacetylase 1","Hdac1","Unknown","HD1, RPD3","MGI:108086","modifier of murine metastable epialleles, D5","Hdac1<MommeD5>",null,"4",{"$nulls":15},"Yes","Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Lethality/prenatal-perinatalEmbryonic lethality during organogenesis* homozygotes die at or before E14.5EmbryogenesisEmbryonic growth arrest * around E8-9Embryonic growth retardation * developmentally delayed at E10.5Growth/sizeEmbryonic growth retardation* developmentally delayed at E10.5","Percentage of cells expressing the Line3 GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Poor",null,null,"MommeD5<+/->;Tg(α-Globin-GFP)3EWh<tg/tg> x Tg(α-Globin-GFP)3EWh<tg/tg>","No","2008-10-17","Cryopreserved sperm"]
[6952,"ENU19 WT:031:a:B6:G3","ANU:ENU19WT:031:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4180,"mNET","C3H.FVB-Tg(Foxa2enhancer.β-globin-LacZ) ",null,"Dominant",{"$nulls":25},"lacZ (Beta-galactosidase)","mouse notochord Foxa2 enhancer element, β-globin minimal promoter",{"$nulls":10},"Normal. LacZ expressed in the 8.0 dpc notochord","Normal. LacZ expressed in the 8.0 dpc notochord","C3H/HeH","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-12-18","Cryopreserved sperm"]
[6704,"Gt4","B6.129-Gtf2ird1<tm2Hrd>/Ausb",null,"Recessive","general transcription factor II I repeat domain-containing 1","Gtf2ird1","Nil","Alb-c-myc line 166.8, Alb/c-myc line 166.8, BEN, binding factor for early enhancer, c-myc line 166.8, Cream1, ESTM9, GTF3, MusTRD1, Tg(Alb1-Myc)166.8Sst, WBSCR11","MGI:1861942","general transcription factor II I repeat domain-containing 1; targeted mutation 2, Edna C Hardeman MGI ID: \tMGI:3698407","Gtf2ird1<tm2Hrd>","MGI:3698407","5",{"$nulls":28},"Abnormal behavior:*Mice display some behavioral and neurological defects that mimic some aspects of the behavioral deficit of Williams syndrome.Craniofacial phenotype:*Unlike human patients with Williams syndrome, mice do not display craniofacial or dental abnormalities.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[6814,"NOD-SBmut10","NOD/Lt-Tn(sb-pTrans-SA-IRESLacZ-CAG-GFP-SD:Neo)10TCB/Apb",null,"Recessive",{"$nulls":25},"TgTn(sb-pTrans-SA-IRESLacZ-CAG-GFP-SD:Neo)2TCB",{"$nulls":11},"unknown","unknown","NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2012-02-08","Cryopreserved sperm"]
[3947,"mommeD6","FVB/NJ-MommeD6/Apb",null,"Semi-dominant",null,null,"Unknown",null,null,"modifiers of murine metastable epiallele D6","MommeD6","MGI:3586553","14",{"$nulls":15},"Yes","Green fluorescent protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~9.5 dpc)","GFP transgene (Line3) expression levels are increased.","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD6<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2008-10-17","Cryopreserved sperm"]
[5348,"NOD.hCD4","NOD-Tg(Cd4-CD4)2362Litt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":10},"CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype.","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","24",null,null,"No","2010-12-15","Cryopreserved sperm"]
[4131,"Line3c","C57BL/6-Tg(HBA1-GFP)3Ew/Apb",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","Green Fluorescent Protein (GFP)","α-Globin (-570 to +37) (4.1kb of enhancer)",{"$nulls":10},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2008-12-07","Cryopreserved sperm"]
[4699,"NOD.Cg-Tg(RIP-Socs1)24Wehi NODPfp","NOD.Cg-Tg(Ins2-Socs1)24Wehi Prf1<tm1Sdz>/WehiApb",null,"Dominant","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfn, Pfp, Prf-1","MGI:97551","perforin 1 (pore forming protein); targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":15},"No","suppressor of cytokine signaling 1 (Socs1)","Rat insulin promoter from RIP7 vector",{"$nulls":10},"90–95% of  Pancreatic β cells did not up-regulate class I MHC in response to 100 U/ml IFN-, whereas all other islets cells were responsive, as measured by flow cytometry. SOCS-1 overexpression in  Pancreatic β cells prevents progression to diabetes in CD8+ TCR transgenic NOD8.3 mice",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm"]
[6322,"Puma/Bim/OT-1","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)1100Mjb",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","a 2-kb fragment of the H-2Kb promoter",{"$nulls":12},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6322,"Puma/Bim/OT-1","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)1100Mjb",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2"]
[5349,"B6.IAE","C57BL/6-H2<dlAb1-Ea>/JApb",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No",{"$nulls":12},"Mice feature immune system perturbations including a dearth of CD4(+) lymphocytes in the thymus and spleen.Mice are susceptible to infection.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","36",null,"Het x Het","No","2010-12-15","Cryopreserved sperm"]
[5350,"NOD.IAE","NOD-H2<dlAb1-Ea>/JApb",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No",{"$nulls":12},"Mice feature immune system perturbations including a dearth of CD4(+) lymphocytes in the thymus and spleen.Mice are susceptible to infection.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","41",null,"Het x Het","No","2010-12-15","Cryopreserved sperm"]
[6719,"cre1","B6-Tg(CMV-cre)1Cgn/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, University of Cologne","human cytomegalovirus (CMV) promoter",{"$nulls":12},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[5316,"RKO 44","B6;129S1-Ryk<tm1Stac>/Apb",null,"Recessive","receptor-like tyrosine kinase","Ryk",null,"ERK-3, Vik","MGI:101766","receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker","Ryk<tm1Stac>","MGI:2667542","9",{"$nulls":28},"Neonatal lethality: most mice died within 1 day of birth, though some survived up to 8 days, and 2 to adulthood.Abnormal gait: mice surviving to adulthood dragged their hindlimbs.Short mandible.Abnormal maxilla morphology: in conjunction with shortened nasal bone, resulting in flattened midface.Abnormal neurocranium morphology: slightly smaller and rounder than that of wild-type or heterozygous mutant mice.Short nasal bone: shortened nasal bone, resulting in flattened midface.Cleft secondary palate: * cleft secondary palate observed in 88% of mice * consequence of abnormally high positioning and enlargement of the tongue.Increased tongue size: enlargement observed around E14, resulting in the disruption of the development of the palatal shelf.Short snout.Microcephaly: exhibited by mice that survived to adulthood.Cachexia.Postnatal growth retardation: growth was severely impaired in mice surviving past the first day of life.Cyanosis: mice were largely unable to suckle, became dehydrated, cyanotic, and exhibited gasping respirations.Short ulna: reduced in length.Abnormal hindlimb morphology: hindlimbs were splayed laterally.Short fibula.Short limbs: 18% to 25% reduction in the length of the long bones.Microphthalmia: bilateral microphthalmia was observed in mice that survived to adulthood.",null,"C57BL/6 X 129S1/Sv","No","No","Yes","No","No","Yes","No","Unknown","0",null,null,"No","2010-11-11","Cryopreserved sperm"]
[6357,"NOD/SCIDeGFP","NOD.Cg-Prkdc<scid> Tg(ActBeGFP)/Ausb","NOD.Cg-Prkdc<scid> Tg(ActBeGFP)/Ausb","Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":16},"transgene insertion 1, Research Institute for Microbial Diseases, Osaka University","chicken beta actin promoter",{"$nulls":10},"The mayority of eGFP expressing mice develop normally.A proportion(7%) of the e-GFP had small bodies,with a body weight of only 50% of the NOD/SCID mice",null,"NOD SCID","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[3948,"mommeD10","FVB/NJ-Baz1b<MommeD10>/Apb","FVB/NJ-Baz1b<MommeD10>","Semi-dominant","bromodomain adjacent to zinc finger domain, 1B","Baz1b","Unknown","Wbscr9, WSTF","MGI:1353499","modifier of murine metastable epialleles, D10","Baz1b<MommeD10>","MGI:3821601","5",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Most homozygotes die perinatally. One-fifth will survive to weaning and are occasionally fertile. Surviving homozygotes are mostly male and are small in size. Homozygotes display craniofacial abnormalities.Decreased body size: at weaning.Decreased fetal size: noticable in utero at E18.5.Short mandible: mandibular hypoplasia, particularly posteriorly.Micrognathia: mandibular hypoplasia.Small parietal bone: shortened 12% relative to controls.Short nasal bone: * shortened 12% relative to controls. * flattened.Abnormal palatine bone morphology: reduced in width.Malocclusion.Short snout: upward curvature of the nasal tip.Broad head: widened bulbous forehead.","Heterozygotes display subtle craniofacial abnormalities. Percentage of cells expressing the GFP transgene (Line3) is decreased (enhancer of variegation).Decreased litter size.Small parietal bone: shortened 12% relative to controls.Short nasal bone: * shortened 12% relative to controls. * flattened.Abnormal palatine bone morphology: reduced in width.","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD10<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2008-10-17","Cryopreserved sperm"]
[7676,"CD4-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Tg(Cd4-Cre)1Cwi/JhmiAnu",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":16},"transgene insertion 1, Christopher B Wilson","CD4",{"$nulls":10},"Egr2 f/f.Egr3-/-.CD4-cre+ mice develop autoimmune disease at around three months of age or older.  Egr2 f/f.CD4-cre+ mice develop milder autoimmune disease and at a slower rate.  Egr3-/- exhibit some neurological defects.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2014-05-09","Cryopreserved sperm"]
[7676,"CD4-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Tg(Cd4-Cre)1Cwi/JhmiAnu",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[4604,"mIMPα2delta","C57BL/6-Tg(EGFP-Kpna2 dominant negative) ",null,"Dominant","karyopherin (importin) alpha 2","Kpna2","Unknown","Importin alpha, m-importin, m-importin-alpha-P1, pendulin, Rch1","MGI:103561",{"$nulls":3},"11",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","EGFP fused to dominant negative Kpna2","Protamine 1",{"$nulls":10},"Fertility maybe affected",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[5330,"RKO C57BL/6","C57BL/6-Ryk<tm1Stac>/Apb",null,"Recessive","receptor-like tyrosine kinase","Ryk","Nil","ERK-3, Vik","MGI:101766","receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker","Ryk<tm1Stac>","MGI:2667542","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes die on the day of birth. Approx. 90% of E18.5 embryos have heart defects, the probable cause of neonatal death. They also have a cleft palate, craniofacial defects, shortened limbs and body axis, inner ear defects and abnormal corpus callosum (brain).Abnormal gait: mice surviving to adulthood dragged their hindlimbs.Short mandible.Abnormal maxilla morphology: in conjunction with shortened nasal bone, resulting in flattened midface.Abnormal neurocranium morphology: slightly smaller and rounder than that of wild-type or heterozygous mutant mice.Short nasal bone: shortened nasal bone, resulting in flattened midface.Cleft secondary palate: * cleft secondary palate observed in 88% of mice * consequence of abnormally high positioning and enlargement of the tongue.Increased tongue size: enlargement observed around E14, resulting in the disruption of the development of the palatal shelf.Short snout.Microcephaly: exhibited by mice that survived to adulthood.Cachexia.Postnatal growth retardation: growth was severely impaired in mice surviving past the first day of life.Cyanosis: mice were largely unable to suckle, became dehydrated, cyanotic, and exhibited gasping respirations.Short ulna: reduced in length.Abnormal hindlimb morphology: hindlimbs were splayed laterally.Short fibula.Short limbs: 18% to 25% reduction in the length of the long bones.Microphthalmia: bilateral microphthalmia was observed in mice that survived to adulthood.","Apparently normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-11-19","Cryopreserved sperm"]
[4719,"TgAPP751 (Tg80.1 line)","B6.SJL-Tg(APP751)80.1Aust ",null,"Dominant","amyloid beta (A4) precursor protein","APP","Unknown","Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II, A4, AD1","MGI:88059",{"$nulls":3},"16",{"$nulls":15},"Yes","amyloid beta (A4) precursor protein","? moPrP, hamster prion protein promotor",{"$nulls":10},"? Transgene primarily expressed in brain. No overt phenotype, normal growth and breeding.",null,"? C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm"]
[6331,"Sey","C57BL/6-Pax6<Sey>",null,"Semi-dominant","paired box gene 6","Pax6","Nil","1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6","MGI:97490","paired box gene 6; small eye","Pax6<Sey>","MGI:1856155","2",{"$nulls":28},"Complete neonatal lethality:*Mice die soon after birth because of inability to breathe during suckling.Anophthalmia:*At E15, homozygotes have no visible eyes.Abnormal nasal cavity morphologyShort snout:*Defects in nasal cavity development results in shortened, imperforate snout.","Abnormal optic cup morphology:*At E15, fissure of optic cup is often delayed in closing.*At E15, there is folding at the margin of the optic cup resulting in a keyhole-shaped opening.Microphthalmia:*At E15 heterozygotes have smaller eyes than wild-type.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5756,"Emx1CreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7520,"QSi5 - albino","Quackenbush Swiss i5 - albino",null,"Dominant",{"$nulls":37},"Superior fecundity. Large litter size even after 50 generations.Mean length of the septum primum or flap valve length (FVL) is linger in QSI5 mice compared to 129T2 - 1.13mm compared to 0.60mm - the mean length of the septum primum or flap valve length (FVL) is strongly inversely correlated with patent foramen ovale (PFO) incidence.Increased lactation.More efficient milk production.Increased platelet count: QSi5 was found to have a mean platelet count of 1062 × 109/L (SD = 8.2 × 109/L, n = 16) versus that of 581 × 109/L (SD = 79 × 109/L, n = 23) in CBA mice.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo"]
[6953,"ENU19 WT:034:a:B6:G3","ANU:ENU19WT:034:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4809,"Cooee","ENU8BAT:044",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[6954,"ENU19 WT:035:a:B6:G3","ANU:ENU19WT:035:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[86,"T-wimp","C57BL/6JSfdAnu-Lcp2<twm>/AnuApb","C57BL/6JSfdAnu-Lcp2<twm>/AnuApb","Recessive","lymphocyte cytosolic protein 2","Lcp2","Reduced","SLP-76, SLP76, twm","MGI:1321402","t-wimp","Lcp2<twm>","MGI:3614800","11","ENSMUSG00000002699","ENSMUST00000052413","Lcp2-001",{"$nulls":7},"33978410","12",null,null,"TGCAGCCCTCAGCCCCATTGGGGAGGTAAGTGTCTGTCATACTGTACCAAGTCCAGAATT","No",{"$nulls":12},"Few naïve CD4⁺ and CD8⁺ T cells, autoimmunity, 5 fold decrease in DP Tcells and significantly fewer CD4⁺ and CD8⁺ SP cells, partial block in T cell deveolpment at the Pre TCR checkpoint, very low expression of CD5 on DP thymocytes, defect in TCR signalling, mutation intrinsic to thymocytes, reduced expression of Slp76, Defects in positive selection and reduced negative thymocyte selection, hypergammaglobulinemia and hyper-IgE",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[4743,null,"B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","Semi-dominant","Ring finger and CCCH-type zinc finger domains 1","Rc3h1","Unknown","Roquin","MGI:2685397","sanroque","Rc3h1<san>","MGI:3581675","1",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":14},"C57BL/JAnu","Yes","No","Yes","Yes","No","Yes","No","Unknown",null,"1","Rc3h1<san/+> x ICOS -/-","No","2009-04-27","Cryopreserved sperm"]
[4743,null,"B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","Semi-dominant","inducible T-cell co-stimulator","Icos","Unknown",null,"MGI:1858745","targeted mutation 1, Richard A Flavell","Icos<tm1Flv>","MGI:2683635","1"]
[7677,"Egr2-GFP","C57BL/6-Egr2<Gfp>/JhmiAnu",null,"Dominant","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296",{"$nulls":3},"10",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-05-09","Cryopreserved sperm"]
[5352,"B6.SOD1.SOD3.Gpx1.Tg","C57BL/6-Tg(H2-K-GPX1,-SOD1,-SOD3/CD55)CCpj/Apb",null,"Dominant",{"$nulls":25},"human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag","H2-K<b>","medium",{"$nulls":9},"Expression of all three enzymes was the only combination protective against hypoxia/reoxygenation. In contrast to single- and double-transgenic grafts, triple-transgenic grafts significantly improved control of blood glucose compared with wild type. In contrast to single- and double-transgenic grafts, triple-transgenic grafts significantly improved control of blood glucose compared with wild type.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2010-12-20","Cryopreserved sperm"]
[{"$nulls":30},"human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag","H2-K<b>","medium"]
[{"$nulls":30},"human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag","H2-K<b>","medium"]
[122,"CD28 -/-","B6.129S2-Cd28<tm1Mak>/ThwAnuApb","B6.129S2-Cd28<tm1Mak>/ThwAnuApb","Recessive","CD28 antigen","CD28","Nil",null,"MGI:88327","targeted mutation 1, Tak Mak","Cd28<tm1Mak>","MGI:1857150","1",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutation of this gene results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm"]
[6955,"ENU19 WT:040:b:B6:G3","ANU:ENU19WT:040:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[294,"eotaxin<tm1> Tg(IL5)","C;B6-Ccl11<tm1Mer> Tg(CD2-Il5)5C2Ldt",null,"Dominant","small chemokine (C-C motif) ligand 11","Ccl11","Nil","eotaxin, Scya11","MGI:103576","chemokine (C-C motif) ligand 11; targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11",{"$nulls":15},"Yes","transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High",{"$nulls":9},"Eosinophil-deficient. Tumor incidence was greatly increased.Eotaxin(-/-) mice with or without the IL-5 transgene, were no more susceptible than WT or IL-5 Tg mice to protracted primary infections with Heligmosomoides bakeri, a parasitic nematode that is restricted to the gut. ",null,"BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2006-05-03"]
[279,null,"129-Ifnar<tm1Agt>/Apb",null,"Recessive","interferon (alpha and beta) receptor 1","Ifnar1","Unknown","CD118, Ifar, Ifrc, INF-a receptor, Infar","MGI:107658","Ifnar1<tm1Agt>","targeted mutation 1, Michel Aguet","MGI:1930950","16",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-02","Cryopreserved sperm"]
[7707,"Adra1aflx","B6(Cg)-Adra1a<tm1c(EUCOMM)Hmgu>/MArpVccrApb",null,"Recessive","adrenergic receptor, alpha 1a","Adra1a",null,"Adra1c","MGI:104773","Adrenergic receptor, alpha 1a; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Adra1a<tm1c(EUCOMM)Hmgu>",null,"14",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25","Cryopreserved sperm"]
[6958,"ENU20:007:a:B6:G3","ANU:ENU20:007:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[649,"HAP KO","Un.129-Hap1<tm1Xjl>",null,"Recessive","huntingtin-associated protein 1","Hap1","Nil","HAP-1","MGI:1261831","huntingtin-associated protein 1; targeted mutation 1, Xiao-Jiang Li","Hap1<tm1Xjl>","MGI:2670598","11",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:* most homozygotes die at 3 to 4 days after birth.* a few survive beyond 9 days of age, in the absence of skin, bone, or organ abnormalities* no homozygotes survive beyond 15 days of age.Absent gastric milk in neonates: mutant pups contain very little gastric milk, suggesting a feeding defect that may retard postnatal growth.Abnormal hypothalamus morphology:* at P1, TUNEL-positive cells are observed in the paraventricular nuclei (PVN) and the lateral hypothalamus (LH) of mutant but not wild-type mice; very few or no TUNEL-positive cells are noted in the arcuate nucleus (ARC) of mutant mice.* by P3, TUNEL-labeled cells are more widely spread in various regions of the hypothalamus which control eating, food intake, and energy metabolism, including the ventromedial hypothalamic nucleus (VMN).Neurodegeneration:* as early as P1, homozygotes display degeneration in specific regions of the hypothalamus that control feeding behavior, as determined by TUNEL staining.* in contrast, other brain regions (e.g. cortex, striatum, cerebellum, and hippocampus) display significantly fewer TUNEL-positive cells or show no difference relative to wild-type mice.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25"]
[6879,"RBC14","FVB/NJ-Hbb-b1<MommeD7>/MarpApb",null,"Dominant","hemoglobin, beta adult major chain","Hbb-b1","Reduced","beta maj, beta major globin, beta1, beta-s","MGI:96021","hemoglobin, beta adult major chain; modifier of murine metastable epialleles, D7","Hbb-b1<MommeD7>","MGI:3821597","7",{"$nulls":28},"Lethal at E18.5 or just after (not present at birth). Embryos are normal until E16.5 where they manifest progressive pallor and reduced fetal liver cellularity.","Microcytic, hypochromic anemia with severe reticulocytosis. Compensatory erythropoiesis with splenic extramedullary hematopoiesis due to red cell destruction. ","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"Heterozygote intercrosses ","No","2012-04-26","Cryopreserved sperm"]
[6956,"ENU20:005:a:B6:G3","ANU:ENU20:005:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[5757,"Emx2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7710,"37L1iKO","B6.Cg-Gpr37L1<tm1d(EUCOMM)Wtsi> Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/JVccrApb",null,"Recessive","G protein-coupled receptor 37-like 1","Gpr37l1",null,"CAG-18, D0Kist8","MGI:1928503","G protein-coupled receptor 37-like 1; targeted mutation 1d, Wellcome Trust Sanger Institute","Gpr37L1<tm1d(EUCOMM)Wtsi>",null,"1",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25"]
[7709,"37L1MCM","B6.Cg-Gpr37L1<tm1d(EUCOMM)Wtsi> Tg(Myh6-cre/Esr1*)1Jmk/JVccrApb",null,"Recessive","G protein-coupled receptor 37-like 1","Gpr37l1",null,"CAG-18, D0Kist8","MGI:1928503","G protein-coupled receptor 37-like 1; targeted mutation 1d, Wellcome Trust Sanger Institute","Gpr37l1<tm1d(EUCOMM)Wtsi>",null,"1",{"$nulls":16},"transgene insertion 1, Jeffery D Molkentin","mouse cardiac-specific alpha-myosin heavy chain","heart",{"$nulls":9},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25","Cryopreserved sperm"]
[7067,"Gardenia","FVB/NJ-Gardenia Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, Gardenia",{"$nulls":4},"Gardenia",null,null,"16",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"Gardenia<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24"]
[6636,null,"GALA-Supreme",null,"Dominant",{"$nulls":37},"To be determined by screening",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-25","Embryo"]
[6414,"G10Δ","B6.CBA-Grb10<Gt(Betageo)1Ward>/Ausb",null,"Recessive","growth factor receptor bound protein 10","Grb10","Nil","5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207","MGI:103232","growth factor receptor bound protein 10; gene trap 1, Andrew Ward","Grb10<Gt(Betageo)1Ward>","MGI:2668436","11",{"$nulls":28},"Enlarged placenta:*The size of the placenta was also increased ~30% relative to wild-type.Increased birth body size:*Neonates are ~30% larger than wild-type.Increased fetal size:*Embryonic overgrowth resulting in neonates that are ~30% larger than wild-type.Enlarged liver:*Disproportionate overgrowth of the liver.","Partial perinatal lethality:*Approximately 12% of mice with a maternally inherited allele die shortly after birth.Paternal imprinting:*Only heterozygotes inheriting the allele from the mother display a phenotype.Enlarged placenta:*The size of the placenta is increased ~30% relative to wild-type.Increased birth body size:*Neonates are ~30% larger than wild-type.Increased fetal size:*Embryonic overgrowth resulting in neonates that are ~30% larger than wild-type.Enlarged liver:Disproportionate overgrowth of the liver.Increased glycogen level:*Hepatocytes have a very high glycogen content.Abnormal pulmonary alveolus morphology:*Mice that die shortly after birth exhibit blood-filled alveoli.Abnormal trachea morphology:*Mice that die shortly after birth exhibit a blood-filled trachea.","CBA/B6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[652,"Activin Beta C+ FL1","C57BL/6-Tg(ACTIVIN-β{C})1Grb/Apb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human activin beta C","CMV","low (2 copies)",{"$nulls":9},"Essentially normal at gross level. male fertility decreases from 10 weeks (decreased sperm production, decreased liter size)","Essentially normal at gross level. male fertility decreases from 16 weeks (decreased sperm production, decreased liter size), evidence of liver disease and prostate hyperplasia","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",null,"3","Het x WT or Het x Het","No","2007-04-25","Cryopreserved sperm"]
[4784,"WT-127","WT Control for hGM-CSF transgenic mutants",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GM-CSF","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[6722,"Sg1","B6.129-Sgca<tm1Kcam>/Ausb",null,"Recessive","sarcoglycan, alpha (dystrophin-associated glycoprotein) ","Sgca","Nil","50DAG, adhalin, Asg ","MGI:894698","sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell","Sgca<tm1Kcam>","MGI:1934922","11",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[4789,null,"BALB/c",null,"Dominant",{"$nulls":37},"Normal.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06"]
[1930,"OT-1","C57BL/6-Tg(TcraTcrb)1100Mjb",null,"Recessive",{"$nulls":25},"transgene insertion 1100, Michael J Bevan","H-2Kb promoter",{"$nulls":10},"Carries a transgenic T cell receptor that recognizes ovalbumin residues 257-264 (SIINFEKL) in the context of H2K<b>",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-23"]
[7525,"B6.3R","B6.3R",null,"Recessive",{"$nulls":37},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo"]
[4792,"B6","C57BL/6J",null,"Dominant",{"$nulls":37},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4793,"CBA","CBA",null,"Dominant",{"$nulls":37},"Normal.",null,"CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[5135,null,"ENU14NIH:089:G3b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Skin continues to grow over the lifetime of the mouse","Normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","Unknown",{"$nulls":3},"No","2010-05-26","Cryopreserved sperm"]
[5227,"129Sv/Ly5.1","129/Sv-Ptprc<a>/Apb",null,"Dominant",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","N/A (homogenous wild type line)","N/A (homogenous wild type line)","129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"More than 10","Sibling mating","No","2010-10-05","Cryopreserved sperm"]
[4795,"FVB","FVB/NJ",null,"Dominant",{"$nulls":37},"Normal.",null,"FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4788,null,"129/SvJ",null,"Dominant",{"$nulls":37},"Normal.",null,"129/SvJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4790,null,"BALB/c",null,"Dominant",{"$nulls":37},"Normal.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[168,"Elf3 knockout","B6.129S4-Elf3<tm1Pjh>/Apb","B6.129S4-Elf3<tm1Pjh>/Apb","Recessive","E74-like factor 3","Elf3","Nil","ESE-1, ESX, jen","MGI:1101781","targeted mutation 1, Paul J Hertzog","Elf3<tm1Pjh>","MGI:2662485","1",{"$nulls":15},"Yes","Neomycin resistance gene",{"$nulls":11},"embryonic lethality during organogenesis: only about 71% of expected numbers of homozygotes are still alive at E11.5postnatal lethality: by weaning, only about 27% of expected numbers are still alive.decreased body size: smaller than controls during suckling period although normal in size from E11.5 to birth. After 6 weeks of age, weight gain is normal and mice attain normal sizecachexia: 2-3 days before death, mice begin to display a wasted phenotype, appear malnourished, lethargic, watery diarrhoealethargy: beginning 2-3 days before deathabnormal intestinal epithelium morphology: intestinal endothelium fails to transform from pseudostratified to columnar by E17.5. Formation of villi is delayed and those present are misshapen. Connective tissue under the lamina propria of the villi is disorganized.abnormal enterocyte morphology: absorptive enterocytes are morphologically abnormal. Tightly packed with apical cytoplasmic snouts. Microvilli are short. Increased numbers of mitochondria and ribosomes.abnormal intestinal goblet cells: reduced numbers of goblet cells producing sialomucin.diarrhoea: watery diarrhea in mice that die starting 2-3 days before death. ","No over phenotype","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10",null,"Het x Het OR Het male x WT female OR Het female x WT male","No","2006-04-15","Cryopreserved sperm"]
[4800,"Rain ; ENU11B6:226b","C57BL/6JAnu-Ptprc<rain>/AnuApb","C57BL/6JAnu-Ptprc<rain>/AnuApb","Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Ly-5, Lyt-4, T200 ","MGI:97810","rain","Ptprc<rain>","MGI:4819248","1","ENSMUSG00000026395","ENSMUST00000027645","Ptprc-201",{"$nulls":7},"140007727","11",null,null,"TGTTATAAATGTGCAGACAGATTTGGGGAGTAAGTATATCGTTTATGTTTATAAAATAAA","Yes",{"$nulls":12},"Shifted CD45 expression measured by flow cytometry",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-10","Cryopreserved sperm"]
[8478,"ASD777:TNFRSF13b:C76R","C57BL/6NCrlAnu-Tnfrsf13b<em1Anu>/AnuApb",null,"Recessive","tumor necrosis factor receptor superfamily, member 13b","Tnfrsf13b","Unknown","1200009E08Rik, Taci","MGI:1889411",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-30","Cryopreserved sperm"]
[4490,"EphA1 conditional transgenic","B6.129-Tg(Ubc-Epha1)1Sld",null,"Dominant",{"$nulls":25},"Eph receptor A1","Ubiquitin C","2.5x  wildtype in tissue tested by QPCR",{"$nulls":11},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"hemizygote x wildtype","No","2009-02-24","Cryopreserved sperm"]
[5498,"Twist-delBp","B6;129-Twist1<tm1Bhr>/WchriApb",null,"Semi-dominant","twist gene homolog 1 (Drosophila)","Twist1","Nil","charlie chaplin, M-Twist, pdt, Pluridigite, Skam10Jus, Ska10","MGI:98872","targeted mutation 1, Richard R Behringer","Twist1<tm1Bhr>","MGI:1857265","12",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutant embyros have neural tube defects and die around E11.","Heterozygous mutants are viable and exhibit features of human Saethre-Chotzen syndrome, including hindlimb polydactyly, craniofacial defects, long bone abnormalities, an abnormal gait and a small size.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","2",null,null,"No","2011-05-04","Cryopreserved sperm"]
[214,"Cryptic","C57BL/6-Cfc1<tm1Mms>",null,"Recessive","cripto, FRL-1, cryptic family 1","Cfc1","Nil","cryptic","MGI:109448","targeted mutation 1, Michael M Shen","Cfc1<tm1Mms>","MGI:2179530","1",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal.      postnatal lethality (J:58104)homozygous mutant mice died within the first 2 weeks after birth, probably because of cardiac abnormalitieslife span/agingpremature death (J:58104)five homozygotes (from >90) survived past weaningcardiovascular systemabnormal direction of looping morphogenesis (J:58104)at 8.5-9.5 dpc, mutant embryos exhibited randomization of cardiac loopingat these stages, abnormal cardiac looping and embryo turning were highly correlateddextrocardia (J:58104)in 36% of mutant mice, the cardiac apex pointed to the right as opposed to the normal leftmesocardia (J:58104)in 12% of mutant mice, the cardiac apex pointed to the middle as opposed to the normal leftabnormal atrial septum morphology (J:58104)88% of mutant mice displayed septal defectsabnormal aorta morphology (J:58104)in wild-type mice, the aorta is dorsal to the pulmonary artery and connects to the left ventricle; in contrast, the mutant aorta was ventral to the pulmonary artery and connected to the right ventricleabnormal patterning of the aortic arch (J:58104)the mutant azygos vein could be located on the left side while the aorta arched to the left (as in wild-type), on the right while the aorta arched rightward, or bilaterally while the aorta arched leftwarddigestive/alimentary systemabnormal stomach morphology (J:58104)many newborn homozygotes exhibited a milk spot on their right side, instead of the leftembryogenesisabnormal direction of embryo turning (J:58104)at 8.5-9.5 dpc, homozygous mutant embryos exhibited randomization of embryo turningabnormal left-right axis patterning (J:58104)E18.5 and neonatal mutant mice (<1 week of age) displayed left-right laterality defects including heterotaxia, randomization of organ situs, and isomerism of bilaterally asymmetric tissuesgrowth/sizeright pulmonary isomerism (J:58104)100% of mutant mice displayed right pulmonary isomerismsitus inversus (J:58104)approximately 50% of homozygotes exhibited inverted situs of visceral organs including the stomach, spleen, and pancreashematopoietic systemabsent spleen (J:58104)100% homozygotes exhibited asplenia or severe hyposplenia","Viable and fertile","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[213,null,"MLC3F-lacZ",null,"Recessive",null,null,"Nil",{"$nulls":5},"Unknown",{"$nulls":15},"Yes","nLacZ","myosin light chain 3f",{"$nulls":10},"Mice are viable and fertile. ",null,"C57BL/6 x FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24"]
[5633,"Backcross B6xCav-1 KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[240,"MLR37","FVB/N-Tg(Cryaa-cre)37Mlr/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 37, Mike Robinson","modified alpha A crystallin promoter with an inserted copy of Pax6 consensus binding site",{"$nulls":10},"Mice express Cre in lens fibres and retina and ciliary body with weak ectopic expression in skin and CNS.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[4186,"CD151 KO","FVB.B6(C)-CD151<tm1Lka>/Apb","FVB.B6(C)-CD151<tm1Lka>/Apb","Recessive","CD151 antigen","Cd151","Nil","PETA-3, SFA-1, Tspan24","MGI:1096360","targeted mutation 1, Leonie K Ashman","Cd151<tm1Lka>","MGI:3050539","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice have kidney defects and eventually develop kidney failure due to problems with glomerular basement membrane formation and maintenance. Mutation is lethal in all cases, at from 4 months to 6 months of age. ",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"No","2008-12-19","Cryopreserved sperm"]
[7031,"APN 235","C57BL/6N-Cdcp1<tm1(KOMP)Wtsi>/Marp",null,"Recessive","CUB domain containing protein 1","Cdcp1 ","Unknown","9030022E12Rik, E030027H19Rik ","MGI:2442010 ","CUB domain containing protein 1; targeted mutation 1, Wellcome Trust Sanger Institute ","Cdcp1<tm1(KOMP)Wtsi>","MGI:4419722","9",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N ","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-07-30","Cryopreserved sperm"]
[4773,"4AT62","ENU4AT:062",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[5466,"MCP1 KO","B6.129S4-Ccl2<tm1Rol>/JApb",null,"Recessive","chemokine (C-C motif) ligand 2","Ccl2","Nil","HC11, MCAF, MCP-1, MCP1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF","MGI:98259","chemokine (C-C motif) ligand 2; targeted mutation 1, Barrett J Rollins","Ccl2<tm1Rol>","MGI:2175911","11",{"$nulls":15},"No",{"$nulls":12},"Increased CD4-positive T cell number: in an EAE model, mutants show an increase in proportion of CD4+ cells and reduction in CD11b+CD4- in the CNS leukocyte infiltrates compared to wild-type, although total numbers of T cells are not different.Decreased leukocyte cell number: numbers of leukocytes isolated from CNS tissue during EAE attacks are about 1/3 of those from wild type mice with comparable EAE severity.Decreased macrophage cell number: age-dependent accumulation of macrophages in the choroids is less than in wild-type mice.Increased neutrophil cell number: 1 and 3 days after femoral artery excision, mice exhibit an earlier increase in neutrophil accumulation (measured by MPO activity) than in similarly treated wild-type mice.Increased osteoclast cell number: * at P5 during tooth eruption * peak osteoclast accumulation occurs at P5 instead of at P9 as in wild-type mice.Abnormal chemokine level: * in thioglycollate- or zymosan- induced peritonitis models, no Ccl2 is detected while reduce levels of Ccl7 are present in peritoneal fluid. * 1 day after femoral artery excision, muscles accumulate more chemoattractants (KC and MIP-2) than in similarly treated wild-type mice.Increased IgG level * at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice. * IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice.Increased IgG1 level: significantly higher levels of anti-MOG35-55 IgG1 antibodies are seen in mutants compared to wild-typeAbnormal macrophage recruitment: * the timing of macrophage recruitment during tooth eruption is different than in wild-type mice with peak numbers occurring earlier than in wild-type mice. * the total number of macrophages recruited is normalImpaired macrophage recruitment: * mutants show impaired macrophage recruitment to the CNS after MOG35-55 induced EAE. * only half the number of macrophages are recruited to the peritoneum in an induced peritonitis model as occurs in wild-type controls. * initially following femoral artery excision.Abnormal neutrophil physiology: the number of neutrophils recruited to the peritoneum in an induced peritonitis model is almost double that controls.Abnormal cytokine secretion: MOG35-55-specific Th1 cytokine responses are diminished in mutants.Abnormal chemokine secretion: * there is no Ccl2 (MCP-1) secretion by peritoneal macrophages activated in vitro compared to controls * secretion of Ccl7 (MCP-3) and Ccl12 (MCP-5) is also dramatically reduced by these activated macrophages.Decreased interferon-gamma secretion: mutants exhibit reduced production of IFN-gamma in response to MOG35-55 induced EAE.Increased interleukin-10 secretion: mutants exhibit enhanced secretion of IL-10 in response to MOG35-55 induced EAE.Decreased susceptibility to experimental autoimmune encephalomyelitis: * homozygotes are resistant to active experimental autoimmune encephalomyelitis (EAE) induction with MOG35-55, with delayed onset of disease, reduced inflammatory reaction including impaired recruitment of macrophages to the central nervous system (CNS), and faster and complete recovery * adoptive transfer of primed T cells from wild-type mice to naive homozygous mutant recipients does not mediate clinical EAE, however wild-type mice receiving mutant T cells do develop clinical EAE.Retinal photoreceptor degeneration: at 16 months.Abnormal retinal pigment epithelium morphology: * after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice. * at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice.Abnormal choroid morphology: age-dependent accumulation of macrophages in the choroids is less than in wild-type miceAbnormal choriocapillaris morphology: at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice.Choroidal neovascularization: * at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice. * after 18 months, 4 of 15 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice. * between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice.Abnormal Bruch membrane morphology: * the Bruch membrane is thickened compared to in wild-type mice after 9 months of age * at 20 months, the outer Bruch membrane is breached by choriocapillary processes unlike in wild-type mice.Retinal outer nuclear layer degeneration: at 16 months.Retinal degeneration: * at 16 months, mice exhibit progressive outer retinal degeneration and confluent areas of visible atrophy unlike in wild-type mice * at 18 months, mice exhibit geographic atrophy unlike in wild-type mice.Retinal deposits: after 9 months of age, mice exhibit subretinal deposits similar to drusen that increase with age unlike in wild-type mice.Alcohol aversion: in female mice.Alcohol preference: * male mice exhibit a greater ethanol preference compared with wild-type (in post hoc analysis) mice, Ccr2<tm1Mae> homozygotes, and Ccl2<tm1Rol> Ccr2<tm1Mae> double homozygotes * female mice exhibit a greater ethanol preference compared with Ccl2<tm1Rol> Ccr2<tm1Mae> double homozygotes and Ccr2<tm1Mae> homozygotes.Decreased drinking behavior: of an ethanol solution in female mice.Decreased alcohol consumption: in female mice compared with wild-type mice and Ccr2<tm1Mae> homozygotes.Increased drinking behavior: * mice exhibit increased drinking of an ethanol solution compared with Ccl2<tm1Rol> Ccr2<tm1Mae> double homozygotes and Ccr2<tm1Mae> homozygotes. * mice exhibit increased drinking of a quinine solution compared with wild-type mice.Increased alcohol consumption: * male mice consume more ethanol than wild-type (in post hoc analysis) mice and Ccl2<tm1Rol> Ccr2<tm1Mae> double homozygotes. * female mice consume more ethanol than Ccl2<tm1Rol> Ccr2<tm1Mae> double homozygotes.Abnormal conditioned taste aversion behavior: * mice exhibit a stronger response to ethanol in an ethanol-induced conditioned taste aversion test compared with similarly treated wild-type mice * however, saccharin consumption is normal.Impaired righting response: mice exhibit longer duration of ethanol-induced loss of righting response compared with similarly treated wild-type mice.Abnormal choriocapillaris morphology: at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice.Choroidal neovascularization: * at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice. * after 18 months, 4 of 15 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice. * between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice.Abnormal blood circulation: following femoral artery excision, mice exhibit a delay in the restoration of perfusion compared with similarly treated wild-type mice.Retinal photoreceptor degeneration: at 16 months.Abnormal retinal pigment epithelium morphology: * after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice. * at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice.Lipofuscinosis: after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice.Accelerated tooth eruption:  * tooth eruption begins at P14 instead of P16 as in wild-type mice. * from P16 to P18, mice exhibit a 31-fold increase in erupted cusps compared with wild-type mice.Increased osteoclast cell number: at P5 during tooth eruptionpeak osteoclast accumulation occurs at P5 instead of at P9 as in wild-type mice.Increased muscle weight: after 1 and 7 days, mice subjected to femoral artery excision exhibit an extended period of increased ischemic muscle weight compared with similarly treated wild-type mice.Abnormal skeletal muscle morphology: following femoral artery excision, muscles accumulate more adipocytes than in similarly treated wild-type mice.Skeletal muscle necrosis: following femoral artery excisionAbnormal muscle regeneration: muscle regeneration, as measured by LDH and fiber size, is impaired following femoral artery excision.",null,"(129S4/SvJae x C57BL/6)F1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-03-22","Cryopreserved sperm"]
[4811,"Banjora","ENU8BAT:070:Banjora",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[4814,"Alba","ENU8BAT:079",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[4819,null,"ENU8BAT:097",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[5761,"EPHA2 KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3419,"OT-1 / Bim KO","C57BL/6-Bcl2l11<tm1.1Ast> Tg(TcraTcrb)1100Mjb/Wehi",null,"Dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan","H-2Kb promoter",{"$nulls":10},"Cross used to create Bim knockout,  OVA specific CD8 T cells.Bim -/-   females often lack vaginal opening.",null,"C57BL/6","No","No","Yes","Yes","No","Yes","No","Unknown","10",null,null,"No","2008-07-14"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[4828,"6AT:062","ENU6AT:062",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[7375,"ENU19:B6:Mlkl","C57BL6NCrlAnu-Mlkl<m1Anu>/Anu",null,"Recessive","mixed lineage kinase domain-like","Mlkl",null,"9130019I15Rik","MGI:1921818",null,"Mlkl<m1Anu>",null,"8","ENSMUSG00000012519","ENSMUST00000120432","Mlkl-002","949","1305","T to A","ENSMUSE00000214984","7","317","Arginine to STOP",{"$nulls":4},"ACAGGCTACACCATTCGGAAACACTCCACAGAAACATCAGCAGCTCCAGTTTCCTCGTAGC",{"$nulls":15},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-11","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[4176,"APN3","B6;129-Uba2<Gt(RRO015)Byg>/MIMR",null,"Recessive","ubiquitin-like modifier activating enzyme 2","Uba2","Unknown","anthracycline-associated resistance, Arx, SAE2, Sumo-1 activating enzyme subunit 2, UBA2, Uble1b","MGI:1858313","ubiquitin-like modifier activating enzyme 2; gene trap RRO015, BayGenomics","Uba2<Gt(RRO015)Byg>","MGI:4329423","7",{"$nulls":15},"No",{"$nulls":12},"Unknown","Normal","C57BL/6 x NODk","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",null,"1","chimera x C57BL/6","No","2008-12-18","Cryopreserved sperm"]
[5764,"EphA4KD",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6959,"ENU20:008:a:B6:G3","ANU:ENU20:008:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[3937,"APN2","B6.129-Stx16<Gt(CD0253)Wtsi>/MIMR",null,"Recessive","syntaxin 16","Stx16","Unknown","SYN16","MGI:1923396","syntaxin 16; gene trap CD0253, Wellcome Trust Sanger Institute","Stx16<Gt(CD0253)Wtsi>","MGI:3864547","2",{"$nulls":15},"Yes",{"$nulls":12},"Unknown at this time","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1",null,null,"No","2008-10-16","Cryopreserved sperm"]
[4835,"TNAP-Cre","BALB/c-Alpl<tm1(cre)Nagy>/AnuApb",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase","TNAP",{"$nulls":10},"Embryonic Lethal",null,"Balb/c","No","No","Yes","No","No","Yes","No","Unknown","8",null,null,"No","2009-09-24","Cryopreserved sperm"]
[6520,"2CLY5.1tg","B6.SJL-Ptprc<a> Tg(Tcra2C,Tcrb2C)1Dlo/Ausb",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":16},"transgene insertion 1, Dennis Y Loh",{"$nulls":11},"Abnormal CD8-positive T cell morphology: CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen.",null,"C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5108,"Plt20","B6.C-Bcl2l1<Plt20>/WehiAnuApb",null,"Recessive","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; platelet 20","Bcl2l1<Plt20>","MGI:3847887","2","ENSMUSG00000007659","ENSMUST00000109820","Bcl2l1-201","44","437","A to G","ENSMUSE00001233620","2","15","Tyrosine to Cysteine",{"$nulls":4},"CCGGGAGCTGGTGGTCGACTTTCTCTCCTACAAGCTTTCCCAGAAAGGATACAGCTGGAGT","No",{"$nulls":12},"Decreased platelet cell number: * platelet counts are 25% of normal * splenectomy only partially restored platelet cell countExtramedullary hematopoiesis: there is a slight increase in splenic erythropoiesis.Increased megakaryocyte cell number: megakaryocyte numbers are significantly elevated compared to controls.Abnormal platelet physiology: platelet half-life is reduced to under 12 hours compared to 57 hours for controls.","Decreased platelet cell number: platelet counts are significantly lower than controls (598x10<3>/microliter vs 1100x10<3>/microliter).Increased megakaryocyte cell number: megakaryocyte numbers are marginally elevated compared to controls.Abnormal platelet physiology: platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours).","BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-04","Cryopreserved sperm"]
[4858,"Jersey","ENU8CAT:049",null,"Dominant","2'-5' oligoadenylate synthetase 2","Oas2","Unknown","2'-5' oligoadenylate synthetase-like 11, Oasl11","MGI:2180852",{"$nulls":3},"5","ENSMUSG00000032690","ENSMUST00000081491","Oas2-002","1214","1294","T to A","ENSMUSE00000490404","6","405","Isoleucine to Asparagine",{"$nulls":4},"CCAGCCCAACAAGCTCTTCCTAAAGCAGATCAAGGAAGCTGTTGACATTATATGTTCCTTC","Yes",{"$nulls":12},"Females fail to lactate between days 1 and 4 (after birth of pups).Pups can be maintained by adding lactating foster mother.","Females fail to lactate by day 8 (after birth of pups).","C57BL/6 x CBA/CaJ","Yes","No","No","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[7718,"MUL1","MULAN","MUL1","Dominant","mitochondrial ubiquitin ligase activator of NFKB 1","Mul1",null,"0610009K11Rik","MGI:1915600",{"$nulls":3},"4",{"$nulls":28},"Mice are slightly smaller in size but appear healthy and behave normally","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2014-07-18","Cryopreserved sperm"]
[2376,"Piaf","ENU7B6:022",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Ataxia",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[6961,"ENU20:010:b:B6:G3","ANU:ENU20:010:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6338,"TLR9","C57BL/6-Tlr9<tm1Aki>",null,"Recessive","toll-like receptor 9","Tlr9","Nil",null,"MGI:1932389","toll-like receptor 9; targeted mutation 1, Shizuo Akira","Tlr9<tm1Aki>","MGI:2660562","9",{"$nulls":28},"Abnormal immune system physiology:*Response to LPS and CpG is completely abrogated.      Impaired NK cell cytolysis:      *No NK cell activation is observed following infection with L. infantum.      Decreased interferon-alpha secretion:      *Following infection with Leishmania baziliensis.      *However, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.      Decreased interferon-beta secretion:      *Following infection with Leishmania baziliensis.      *However, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.      Decreased interleukin-12b secretion:      *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice.      *Unlike in wild-type mice, IL-12p40 production from dendritic cells following infection with Leishmania infantum is indetectable.      Decreased tumor necrosis factor secretion:      *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.      Decreased susceptibility to experimental autoimmune encephalomyelitis:      *Myelin oligodendrocyte glycoprotein injection results in delayed onset of disease, 17.9 days after injection rather than 15.9 days as in controls.      *Fewer infiltrating foci in the spinal cord.      Abnormal response to infection:      *Following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a partially decreased immune response in terms of TNF secretion and response to CpG.         Decreased susceptibility to parasitic infection:         *Resistant to cerebral malaria.         *Reduced accumulation of hemozoin.         *Less upregulation of TNF-alpha in Plasmodium infection.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6211,"B6/bcl-x flox","B6.129S6-Bcl2l1<tm1Mam>/Wehi",null,"Recessive","BCL2-like 1 ","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX ","MGI:88139","BCL2-like 1; targeted mutation 1.1, Lothar Hennighausen","Bcl2l1<tm1.1Mam>","MGI:2176700","2",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Unknown","Yes","Yes","No","Yes","No","Unknown","6",null,null,"No","2011-09-13"]
[6968,"ENU20:022:a:B6:G3","ANU:ENU20:022:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4880,"B6.Rag1/Gal KO","C57BL/6-Rag1<tm1Mom> Ggta1<tm1>/Apb",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.All blood/tissue samples lack Gal expression.Cortical cataracts developed in all GalT-/- mice at 4-6 weeks of age.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-28","Cryopreserved sperm"]
[6969,"ENU20:023:b:B6:G3","ANU:ENU20:023:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[5471,"APN 78","C57BL/6N-Zdhhc2<tm1a(KOMP)Wtsi>/Marp",null,"Recessive","zinc finger, DHHC domain containing 2","Zdhhc2",null,null,"MGI:1923452","zinc finger, DHHC domain containing 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Zdhhc2<tm1a(KOMP)Wtsi>","MGI:4362764","8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-03-25","Cryopreserved sperm"]
[5470,"APN 82","C57BL/6N-Gkn2<tm1(KOMP)Vlcg>/Marp",null,"Recessive","gastrokine 2","Gkn2","Unknown",null,"MGI:1913534","gastrokine 2; targeted mutation 1, Velocigene","Gkn2<tm1(KOMP)Vlcg>","MGI:4399717","6",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-03-25","Cryopreserved sperm"]
[4904,"IL2 KO TCR Arjuna","C57BL/6-IL2<tm1Hor> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","interleukin 2","IL2","Nil","Il-2","MGI:96548","targeted mutation 1, Ivan Horak","Il2<tm1Hor>","MGI:1857191","3",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Increased T cell numbers and prolonged T cell response to antigen.Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background. Phenotype Screen: Urine glucose","Normal","C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-10-09","Cryopreserved sperm"]
[6971,"ENU20:026:b:B6:G3","ANU:ENU20:026:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4910,"MommeR1","FVB-Foxo3<MommeR1>/Apb",null,"Recessive","forkhead box O3","Foxo3","Unknown","Fkhr2, FKHRL1, Foxo3a","MGI:1890081","modifier of murine metastable epialleles, R1","Foxo3<MommeR1>",null,"10",{"$nulls":15},"Yes","Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Percentage of cells expressing the Line3 GFP transgene is decreased (enhancer of variegation).",null,"FVB/NJ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Poor",null,null,"MommeD5<+/->;Tg(α-Globin-GFP)3EWh<tg/tg> x Tg(α-Globin-GFP)3EWh<tg/tg>","No","2009-10-09","Cryopreserved sperm"]
[189,"M72-IRES-tau:GFP","Olfr160<tm6Mom>",null,"Dominant","olfactory receptor 160","Olfr160","Unknown","GA_x6K02T2PVTD-31389446-31388517, M72, MOR171-3, MOR171-3","MGI:1931271","targeted mutation 6, Peter Mombaerts","Olfr160<tm6Mom>","MGI:3692202","9",{"$nulls":15},"No",{"$nulls":12},"M72 odorant receptor neruons express GFP",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[192,"CD26 -/-","C57BL/6-Dpp<tm1Nwa>",null,"Recessive","dipeptidylpeptidase 4","Dpp4","Nil","Cd26, Dpp-4, THAM","MGI:94919","targeted mutation 1, Nicolai Wagtmann","Dpp4<tm1Nwa>","MGI:2150161","2",{"$nulls":15},"Yes",{"$nulls":12},"Reduced type II diabetes symptoms in diabetes models. Reduced insulin resistance when fed high fat diet.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17"]
[4928,"Jaffa","DBA1-Acan<tm2Afos>",null,"Recessive","aggrecan","Acan","Normal","Agc1, Cspg1","MGI:99602","targeted mutation 2, Amanda J Fosang","Acan<tm2Afos>","MGI:3713763","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice are phenotypically normal. Mice show part protection against aggrecanolysis and cartilage erosion in models of experimentally induced arthritis.",null,"DBA1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-12"]
[2372,null,"ENU8B6:061",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th2 polarized IgG1 antibody response to chicken gammaglobulin (CGG). ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[6972,"ENU20:027:a:B6:G3","ANU:ENU20:027:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[3437,"common beta chain KO","C57BL/6-Csf2rb<tm1Cgb>/Wehi",null,"Recessive","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, C Glenn Begley","Csf2rb<tm1Cgb>","MGI:2181245","15",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16"]
[4906,"Stiliom; ENU4AT:032","B6;NODAnu-Tomm40<Stil>/AnuApb",null,"Semi-dominant","translocase of outer mitochondrial membrane 40 homolog (yeast)","Tomm40","Unknown","Tom40","MGI:1858259","Stiliom","Stil",null,"7","ENSMUSG00000002984","ENSMUST00000093552","Tomm40-202","977","1048","C to T","ENSMUSE00000582554","10","326","Alanine to Valine",{"$nulls":4},"CTCTGTGAACAGTAACTGGATCGTGGGCGCCACGCTGGAGAAGAAGCTTCCGCCCTTGCCC","Yes",{"$nulls":12},"Lethal lung haemorrhage at 4 – 6 weeks, blood vessel fragility may be caused by suspected transdifferentiation of smooth muscle cells into skeletal muscle (a physiological process in the oesophagus) occurring throughout the body.TOM complex is absent in Blue-native PAGE analysis","Blue-native PAGE shows reduced levels of TOM complex in mitochondria in HETs; Monomeric Tomm40 is detected, but the mutant version of the protein migrates faster on SDS-PAGE than the wild-type protein (data from Diana Stojanovski and Mike Ryan at Latrobe.","C57BL/6JSfdAnu x NODk","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-10-09","Cryopreserved sperm"]
[4549,null,"B6.129-Ring1<tm1Mvi>/WehiApb",null,"Recessive","ring finger protein 1","Ring1","Nil",null,"MGI:1101770","targeted mutation 1, Miguel Vidal","Ring1<tm1Mvi>","MGI:1926913","17",{"$nulls":15},"Yes",{"$nulls":12},"Increased rib number* 42% had 8 vertebrosternal ribs instead of 7Abnormal vertebrae morphology * 100% exhibited vertebrae abnormalities with abnormal C1 and C2Abnormal cervical atlas morphology Anormal cervical axis morphology Vertebral transformation * anterior transformations",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,null,"No","2009-03-02","Cryopreserved sperm"]
[5019,"B6 Lac I","B6.FVB/n-Lac I (USA) Tg1",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[7073,"B6-ASCIZ-Nkx2.1-eYFP","C57BL/6-Atmin<tm1Jhh> Gt(ROSA)26Sor<tm(EYFP)Cos> Tg(Nkx2.1-cre)2Sand/J",null,"Recessive","ATM interactor","Atmin",null,"Asciz, MGC:79206, mKIAA0431","MGI:2682328","targeted mutation 1, Jorg Heierhorst","Atmin<tm1Jhh>",null,"8",{"$nulls":16},"transgene insertion 2, Stewart Anderson","Nkx2-1",{"$nulls":9},"6","Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-09-03","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[7678,"ENU18.FLT3-ITD.0.24.B6","B6.129-Flt3<tm1Dgg> Ndufa10<m1Anu>/AnuApb",null,"Recessive","NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10","Ndufa10",null,"2900053E13Rik","MGI:1914523",{"$nulls":3},"1",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"FLT3 hom's have myeloid proliferation Ndufa10 is unknown, contact Tom Gonda. ","no phenotype in hetrozygous mice",null,"Yes","Yes","Unknown","Yes","Yes","Unknown","Yes","Poor","BC7",null,"het by het is best","No","2014-05-12","Cryopreserved sperm"]
[7678,"ENU18.FLT3-ITD.0.24.B6","B6.129-Flt3<tm1Dgg> Ndufa10<m1Anu>/AnuApb",null,"Recessive","FMS-like tyrosine kinase 3","Flt3",null,"CD135, Flk2, Flk-2, Flt-3, wmfl","MGI:95559","FMS-like tyrosine kinase 3; targeted mutation 1, D Gilliland","Flt3<tm1Dgg>","MGI:3763385","5",{"$nulls":9},"Unknown to Unknown"]
[7725,"Solox Low AR","B6;CBA-Ifnar2<tm1Pjh> Tg(sIfnar2)1Pjh/MarpApb",null,"Recessive","interferon (alpha and beta) receptor 2","Ifnar2","Increased","Ifnar-2 ","MGI:1098243 ","interferon (alpha and beta) receptor 2; targeted mutation 1, Paul J Hertzog","Ifnar2<tm1Pjh>","MGI:2680693","16",{"$nulls":16},"interferon (alpha and beta) soluble receptor 2 ","mouse Ifnar2","Low expression ",{"$nulls":9},"Normal. Increased expression of soluble IFNAR2 receptor.","Normal. ","CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-08-21","Cryopreserved sperm"]
[4476,null,"C.B6-TLR2<tm1Aki> TLR4<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 4","Tlr4","Unknown","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; targeted mutation 1, Shizuo Akira ","Tlr4<tm1Aki>","MGI:1860885","4"]
[4465,null,"C57BL/6-IL5<tm1Kopf> Eotaxin<tm1Mer>/AnuApb",null,"Recessive","chemokine (C-C motif) ligand 11","Ccl11","Unknown","eotaxin, Scya11","MGI:103576","targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11"]
[4477,null,"B6.129-Hcn1<tm2Kndl>/AnuApb",null,"Recessive","hyperpolarization-activated, cyclic nucleotide-gated K+ 1","Hcn1","Nil","Bcng1, HAC2","MGI:1096392","targeted mutation 2, Eric R Kandel","Hcn1<tm2Kndl>","MGI:2686951","13",{"$nulls":15},"Yes",{"$nulls":12},"Behavior/neurological phenotype* basic motor functions were all normalIncreased thigmotaxis * observed during water maze testsAbnormal eye blink conditioning behavior * a deficiency was observed in latency to peak conditioned responseAbnormal learning/ memory Abnormal motor learning* there is a learned motor skill deficit in a rotorod test* impairment apparently involves learning and memory of relatively fast coordinated movementsAbnormal spatial learning* impaired learning in a water maze test",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm"]
[6587,"MLR34","FVB/N-Tg(Cryaa-cre)34Mlr/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 34, Mike Robinson","modified alpha A crystallin promoter with an inserted copy of Pax6 consensus binding site",{"$nulls":10},"Nil.  Mice express Cre in lens fibres, and retina and various embryonic structures","Normal","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","unkown",null,"inbred","No","2011-09-23","Cryopreserved sperm"]
[1507,null,"C57BL/6-IL12b<tm1Jm> IL18<tm1Aki>/Apb",null,"Recessive","interleukin 12b","Il12b","Unknown","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants have reduced ability to produce IFN-γ, reduced NK cell activity, impaired T helper cell response and increased susceptibility to bacterial growth and tuberculosis. NK activity lower than seen in either single gene knockout.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-04","Cryopreserved sperm"]
[7534,"ENU20Flt3ITD:37","ENU20FLT3-ITD:037",null,"Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown"]
[1553,null,"BALB/c-IL9<tm1Anjm> Tg(iFABPp-IL9)?AnuApb",null,"Recessive","interleukin 9","Il9","Nil","Il-9, P40","MGI:96563","interleukin 9; targeted mutation 1, Andrew NJ McKenzie","Il9<tm1Anjm>","MGI:2656470","13",{"$nulls":15},"Yes","Interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[4969,"Beta Tg","C.129/Sv-Tg(hGM-CSFRb) Csf2rb<tm1Clsc> Csf2rb2<tm1Cgb>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Unknown","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":15},"Yes","human beta common chain receptor for GM-CSF/IL-3/IL-5","human ubiquitin C promoter","low",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10","0","Purchased BALB/c mated with transgenic mouse from colony to maintain colony","No","2010-01-15","Cryopreserved sperm"]
[6975,"ENU20:028:b:B6:G3","ANU:ENU20:028:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[4992,"c-cbl KO","STOCK H2<k2> Cbl<tm1Ddlb>/AnuApb ",null,"Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"129/1SV x C57BL/6 x C57BL/10.BR-H2<k2>","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[4965,null,"FVB/N.129-Gt(ROSA)26Sor/AusbApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","MGI:1890203","6",{"$nulls":28},"Normal","Expresses Beta-galactosidase in cells where Cre recombinase is expressed","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-15","Cryopreserved sperm"]
[2354,"Azharrudin","B6.129S2-Cd28<tm1Mak> Tg(TcraTcrb)1100Mjb",null,"Recessive","CD28 antigen","CD28","Nil","OT-1, OT-I, OT-I(OVA)TCR, OT-ITCR, OT1, OTI, OVA-tcr-I, OVA-Tg, TCR-OT-I, Tg(OT-I), Tg(TcrOva)1100Mjb","MGI:88327","targeted mutation 1, Tak Mak","Cd28<tm1Mak>","MGI:1857150","1",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":11},"The OT-1 strain carries a transgenic T cell receptor that recognizes ovalbumin residues 257-264 (SIINFEKL) in the context of H2K<b>",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-11","Cryopreserved sperm"]
[5639,"BKLF/B",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3564,null,"C57BL/6.CBA-Sfpi1<tm1.2Nutt> Tg(CAG-cre/Esr1)5Amc",null,"Semi-dominant","SFFV proviral integration 1","Sfpi1","Unknown","Dis-1, PU.1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1","MGI:98282","SFFV proviral integration 1; targeted mutation 1.2, Stephen L Nutt ","Sfpi1<tm1.2Nutt>","MGI:3578011","2",{"$nulls":15},"Yes","transgene insertion 5, Andrew P McMahon","chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer",{"$nulls":10},"cre-ER fertility - sterile","Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioural abnormalities.","C57BL/6 x CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01"]
[7392,"B6.Nramp","B6.129-Slc11a1<r>/Apb",null,"Dominant","solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1","Slc11a1","Normal","Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Lsh, Nramp, Nramp1","MGI:1345275","solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; host resistance (Bcg/Ity/Lsh)","Slc11a1<r>","MGI:1857756","1",{"$nulls":28},"Decreased susceptibility to bacterial infection:the mutation results in Gly at position 105 substitution within predicted transmembrane domain 2 of Nramp.This results in resistance to infection with Mycobacteria, Salmonella and Leishmania","Similar to hom state but resistance is intermediate.","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent","13",null,null,"Yes","2013-08-06","Cryopreserved sperm"]
[2396,"B6.TnfRI-/-RII-/-","B6.129S-Tnfrsf1a<tm1Imx> Tnfrsf1b<tm1Imx>/J",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Nil","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1a<tm1Imx>","MGI:1857468","6",{"$nulls":15},"No",{"$nulls":12},"Increased circulating tumor necrosis factor level: two hours post lipopolysaccharide (LPS) challenge serum levels are 15-20 fold higher than controls, however, TNF kinetics and activity are not altered.Decreased susceptibility to endotoxin shock: exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS).Decreased inflammatory response: M. faeni- induced neutrophil accumulation in the lung is decreased as compared to control, however monocyte and lymphocyte levels are comparable to control.Osteomyelitis:* osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp* the osteolytic lesions continue to be larger for at least 38 days after innoculation.Increased susceptibility to bacterial infection: mice have 3 log greater bacterial penetration of the dental pulp eight days after experimental bacterial infection.Necrosis:* mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation.* complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation.Increased bone resorption:* there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp.* osteoclast activity of the molars is almost 2-fold higher than in wild-types 7 days after bacterial inoculation.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-20","Cryopreserved sperm"]
[5801,"Genia (ko) x Teague (ko)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5015,"MHC II -/- ","C57BL/6-MHC II-/-",null,"Recessive",{"$nulls":39},"6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5067,"ED1f","EDD1 KO",null,"Recessive",{"$nulls":37},"Unknown",null,null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","10",null,null,"No","2010-03-25","Cryopreserved sperm"]
[5026,"Bertolino","Bertolino",null,"Recessive",{"$nulls":39},"1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5027,"MTKneo","Outbred ICR M-TKneo2",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5064,"Zic5 K363R:C3H/HeH","C3H/HeH-Zic5<K363R>",null,"Recessive","Zinc finger protein of the cerebellum 5","Zic5","Unknown","odd-paired related, Opr","MGI:1929518",{"$nulls":3},"14",{"$nulls":15},"Yes",{"$nulls":12},"Viable and fertile","Viable and fertile","C3H/HeH","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"Homozygote male paired with homozygote female","No","2010-03-25","Cryopreserved sperm"]
[5014,"Anne","FVB/n-LAC 1 Tg1 (USA) (ASD068)",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5023,"Waugh","BALB/c-Homo Rosa EGFP<tg1>",null,"Dominant",{"$nulls":39},"9","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[5807,"GH-GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5806,"GFAPCre x Epha4Loxp",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4870,"Bc.HTF1.Tg","BALB/c-Tg(H2-K-huFUT1)1/Apb",null,"Dominant",{"$nulls":25},"human fucosyltransferase 1","H2-K<b>","All blood/tissue samples express human fucosyltransferase 1",{"$nulls":9},"Attempts to breed homozygous animals failed. Unknown if homozygous transgene expression is embryonic lethal.","Normal.All blood/tissue samples express human fucosyltransferase.","BALB/c","No","No","Yes","No","No","Yes","No","Unknown","15",null,null,"No","2009-09-28","Cryopreserved sperm"]
[5068,null,"ENU8C:032",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-03-25","Cryopreserved sperm"]
[4942,"osterix-cre","B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Andrew P McMahon"," tetracycline-regulated transactivator (tTA) cassette upstream of a tetracycline-responsive element (tetO)",{"$nulls":11},"Hemizygous mice are viable and fertile. The Sp7 promoter limits EGFP-Cre fusion protein expression to the osteoblast lineage during embryonic/early postnatal development. Expression can be stopped by tetracycline/doxycycline addition. Fusion protein activity is largely absent from chondrocytes.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2009-12-04","Cryopreserved sperm"]
[7731,"MPEG1 targeted KO clone 1B","C57BL/6J-Mpeg1<tm1Pib>/Pib",null,"Dominant","macrophage expressed gene 1","Mpeg1",null,"Mpg-1, MPS1","MGI:1333743",{"$nulls":3},"19",{"$nulls":28},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-09-01","Cryopreserved sperm"]
[6980,"ENU20:034:b:B6:G3","ANU:ENU20:034:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6988,"ENU20:047:a:B6:G3","ANU:ENU20:047:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6985,"ENU20:043:a:B6:G3","ANU:ENU20:043:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[6989,"ENU20:051:b:B6:G3","ANU:ENU20:051:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm"]
[5063,"Montu","C.C3H-Rps7<Mtu>/AnuApb",null,"Semi-dominant","ribosomal protein S7","Rps7","Unknown","S7","MGI:1333818","Montu","Rps7<Mtu>","MGI:3043039","12",{"$nulls":15},"Yes",{"$nulls":12},"Unkown. Assumed lethal.","Phenotype may include variable ventral spotting, tail kinks and small size compared to littermates.","BALB/c x C3H/HeH","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2007-05-02","Cryopreserved sperm"]
[5643,"Bre-LacZ x CD1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7733,null,"Prox1-GFP",null,"Dominant",{"$nulls":25},"GFP","Prox1",{"$nulls":10},"Don't know",null,null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-09-05","Cryopreserved sperm"]
[5007,"ED2f","EDD1 KO",null,"Recessive",{"$nulls":37},"Unknown",null,null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","10",null,null,"No","2010-02-22","Cryopreserved sperm"]
[2378,"ENU8F:030 , Hipster","B6Apb;CB-Adamts20<hip>/Apb","B6Apb;CB-Adamts20<hip>/Apb","Recessive","a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20","Adamts20","Normal","ADAMTS-20, bt","MGI:2660628","a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20; hipster","Adamts20<hip>","MGI:3847117","15","ENSMUSG00000022449","ENSMUST00000035342","Adamts20-001","3664","3833","G to A","ENSMUSE00000646542","26","1221","Glycine to Arginine",{"$nulls":4},"GGTCACCATGTTCAGCCTCCTGTGGACATGGGAAAACCACCCGACGTGTTTTATGCGTGAA","No",{"$nulls":12},"Coat abnormality. Belted, White spotting.Affected mice develop a white stripe transverse across abdomen or a large white spot in the same location.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[5074,"Rocky","FVB/N-MommeD8",null,"Semi-dominant","modifier of murine metastable epialleles, D8","MommeD8","Unknown",null,"MGI:3821592","modifier of murine metastable epialleles, D8","MommeD8","MGI:3821599","4",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","Green Fluorescent Protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Mutant mice show a reduction in survival past weaning. Survivors at weaning are smaller than controls.Postnatal lethality: * few animals survive to weaning * normal litter size at birthDecreased body size: at weaning",null,"FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD8<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2010-03-25","Cryopreserved sperm"]
[5071,"BALB/c-CMV1r","BALB/c.B6-Klra8<Cmv1-r>",null,"Dominant",null,null,"Unknown",{"$nulls":4},"MGI:3579319","Unknown"]
[6997,"ENU21:007:a:B6:G3","ANU:ENU21:007:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[6406,"TYRcn","B6(Cg)-Tyr<c-2J>/JAusb",null,"Recessive","tyrosinase","Tyr","Nil","skc35","MGI:98880","tyrosinase; albino 2 Jackson","Tyr<c-2J>","MGI:1855985","7",{"$nulls":28},"Absent hair follicle melanin granules:*Forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants.Absent coat pigmentation:*Albino coat.Absent skin pigmentationOcular albinism:*Total iris albinismAbnormal aqueous drainage system morphology:*Had mild focal angle developmental defects, whereas pigmented mice had no observed defects.Abnormal retina morphology:*Increased total number of cells in temporal retina during E11-13.*Sustained, early production of ipsilateral retinal ganglion cells up to E14.*Increased surface area of temporal retina, as well as additional sectors during E11-13.      Abnormal retinal photoreceptor morphology:        *Background Sensitivity: mean synaptic ribbon length is decreased in comparison to C57BL/6J.        Decreased retinal photoreceptor cell number:          *Increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels.      Abnormal retinal ganglion layer morphology:        *Beginning at E11 through E16, cells exhibit smaller size and abnormal packing and organization.      Retinal degeneration:Abnormal eye physiology:*Resistant to light damage as compared to albino BALB/cByJ      Abnormal eye electrophysiology:        *Reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram.      Abnormal intraocular pressure:        *Increased pressure as compared to pigmented C57BL/6J.      Abnormal vision:        *Dark-adapted threshold s are elevated (decreased sensitivity) in comparison to C57BL/6J.Increased cellular sensitivity to ionizing radiation:*Mice show dose-dependent DNA lesion formation (cyclobutane dimers) from UV-B exposure, but wild-type or forskolin-treated Mc1r<e> mutants show little damage.Abnormal keratinocyte apoptosis",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7542,"ENU22::PAN2:B6","C57BL/6NCrlAnu-Pan2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Pan2<m1Anu>/AnuApb","Recessive","PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)","Pan2","Unknown","1200014O24Rik, Usp52","MGI:1918984","PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae); mutation 1, The Australian National University","Pan2<m1Anu>","MGI:5563441","10","ENSMUSG00000005682","ENSMUST00000005825","Pan2-201","1408","1662","C to T","ENSMUSE00000271028","9","470","Glutamine to STOP",{"$nulls":4},"AGTCAGACCATGAATTTGACAACTTCAGCCAAGTCACGGAGTCACCGACAGGGCGAGAAGA",{"$nulls":13},"Embryonic Lethal",null,"C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"G5",null,"No","2013-12-13","Cryopreserved sperm"]
[6825,"MT-1/II KO","B6.129-Mt1<tm1Rch> Mt2<tm1Rch>/Apb",null,"Recessive","metallothionein 1","Mt1","Reduced","Mt-1, MT-I","MGI:97171","metallothionein 1; targeted mutation 1, Anna E Michalska","Mt1<tm1Rch>","MGI:2668454","8",{"$nulls":28},"Increased circulating alanine transaminase level: in acetaminophen-treated miceAbnormal ion homeostasis:  * increased cadmium sensitivity * take up a hunched back posture, ruffed coat and display general lethargyAbnormal lipid homeostasis: acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice.Increased sensitivity to xenobiotic induced morbidity/mortality: mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice.Increased physiological sensitivity to xenobiotic: * mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice * acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice * hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells * however, acetaminophen metabolism is normalIncreased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.Abnormal hepatocyte morphology: hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells.Hepatic necrosis: in acetaminophen-treated micetumorigenesis.Increased tumor incidence: 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks).Increased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2012-02-27","Cryopreserved sperm"]
[6799,"TGFbr2f","B6.129S6-Tgfbr2<tm1Hlm>/Ausb",null,"Recessive","transforming growth factor, beta receptor II ","Tgfbr2",null,"1110020H15Rik, TbetaR-II, TbetaRII, TBR-II ","MGI:98729 ","transforming growth factor, beta receptor II; targeted mutation 1, Harold L Moses ","Tgfbr2tm1Hlm ","MGI:2384511","9","ENSMUSG00000032440",{"$nulls":27},"Homozygous mice are fertile and phenotypically normal. Preweaning mortality 8.4%","Normal","B6.129S6 ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Homozygous breeding","No","2012-01-19"]
[7000,"ENU21:011:a:B6:G3","ANU:ENU21:011:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[7003,"ENU21:017:a:B6:G3","ANU:ENU21:017:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[7007,"ENU21:022:b:B6:G3","ANU:ENU21:022:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[6418,"A20","B6.Cg-Tnfaip3<tm1Ama>/AnuAusb?",null,"Recessive","tumor necrosis factor, alpha-induced protein 3","Tnfaip3","Nil","A20, Tnfip3, zinc finger protein A20","MGI:1196377","tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma","Tnfaip3<tm1Ama>","MGI:3055173","10",{"$nulls":28},"Abnormal cytokine secretion:*Bone marrow derived macrophages produce more TNF, IL-6, and nitric oxide in response to LPS treatment compared to wild-type macrophages.Abnormal inflammatory response:*The absolute number and percentage of myeloid cells is increased in multiple tissues.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5324,"Gin; col2a1Cre","C57BL/6-Tg(Col2a1-cre)1Asz",null,"Dominant",{"$nulls":25},"transgene insertion 1, Attila Aszodi","Col2a1","7 copies",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2010-11-17"]
[7009,"ENU21:026:b:B6:G3","ANU:ENU21:026:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[2375,"Eddie ; ENU6WTNIH:028","CBA;B6JSfdAnu-Kcnn2<eddie>/AnuApb",null,"Recessive","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2","Kcnn2",null,"SK2, small conductance calcium-activated potassium channel 2","MGI:2153182","eddie",null,null,"18","ENSMUSG00000054477","ENSMUST00000066890","Kcnn2-201",{"$nulls":12},"No",{"$nulls":12},"Generalised shaking, mild hypermetria, jerky movements, non progressive. First noted at weaning.",null,"C57BL/6 x CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm"]
[7010,"ENU21:027:a:B6:G3","ANU:ENU21:027:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[7013,"ENU21:032:b:B6:G3","ANU:ENU21:032:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm"]
[1736,"B6.EµSV-v-abl 1","C57BL/6-Tg(Igh-Abl1)1Sco/Wehi",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","transgene insertion 1, Suzanne Cory ","mouse Igh enhancer and the SV40 early promoter",{"$nulls":11},"Low incidences of plasmacytoma. Look out for dragging hind legs, enlarged spleen, enlarged menteric lymph nodes - tumours. Visually check daily.1-2% will die at 20 weeks of age, 19-20% will die at 1 year. Mice die as a result of plasmcytoma. Mice will bear one of the following tumours: lymphoma, splenomegaly, messentary associated, abdominal, caecal, Peyer's Patches. They may also suffer from small bowel obstruction, intestinal haemorrhage, hind leg paralysis, intussusception.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[2435,"Louise2 ; TLK-2","C57BL/6JSfdAnu-Tg(TLK2mHEL)2Ccg/AnuApb","C57BL/6JSfdAnu-Tg(TLK2mHEL)2Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid",{"$nulls":9},"Express low levels of membrane bound HEL in thyroid. Low serum levels of HEL detected.",null,"C57BL/6JStdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5","sib x sib","No","2008-01-13","Cryopreserved sperm"]
[8246,"Aim2 KO","C57BL/6N-Aim2<tm1.1Vmd>/VmdAnu",null,"Recessive","absent in melanoma 2","Aim2","Nil","Ifi210, LOC383619","MGI:2686159","absent in melanoma 2; targeted mutation 1.1, Vishva M Dixit","Aim2<tm1.1Vmd>","MGI:5428935","1",{"$nulls":28},"Abnormal macrophage physiology:• improved cell viability following transfection with poly(dA:dT) or pcDNA3• improved bone marrow derived macrophage viability following infection with F. tularensisAbnormal cytokine secretion.Increased interferon-beta secretion:• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3Decreased interleukin-1 beta secretion:• in LPS-primed bone marrow derived macrophages or peritoneal macrophages stimulated by dsDNA• bone marrow derived macrophages do not secrete IL1B in response to F. tularensisDecreased interleukin-18 secretion:• in LPS-primed bone marrow derived macrophages stimulated by dsDNAIncreased tumor necrosis factor secretion:• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3Increased susceptibility to bacterial infection:• fail to control F. tularensis infection",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-04-20"]
[7546,"APN 354","C57BL/6N-A<tm1Brd> Wars<tm1a(EUCOMM)Hmgu>/MarpApb",null,"Recessive","tryptophanyl-tRNA synthetase","Wars  ",null,null,"MGI:104630 ","tryptophanyl-tRNA synthetase; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH12","Warstm1a(EUCOMM)Hmgu","MGI:4435065","1",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-12-18","Cryopreserved sperm"]
[6656,"Vasa-cre","FVB-Tg(Ddx4-cre)1Dcas/J/Ausb",null,"Semi-dominant",{"$nulls":25},"transgene insertion 1, Diego Castrillon",{"$nulls":13},"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[5408,"Gp130Y757f / Stat3+/- / Stat1-/-","STOCK Il6st<tm1Ern> Stat3<tm1Aki> Stat1<tm1Rds>/LudApb",null,"Recessive","signal transducer and activator of transcription 1","Stat1",null,null,"MGI:103063","signal transducer and activator of transcription 1; targeted mutation 1, Robert D Schreiber","Stat1<tm1Rds>","MGI:1861949","1",{"$nulls":15},"No"]
[8479,"ENU22::ANAPC1","C57BL/6NCrlAnu-Ighm<m1Anu>/AnuApb",null,"Recessive","immunoglobulin heavy constant mu","Ighm","Unknown","BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT","MGI:96448",{"$nulls":3},"12",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-05-01","Cryopreserved sperm"]
[1728,"Pkd1 KO","C57BL/6-Pkd1<tm1Jzh>",null,"Recessive","polycystic kidney disease 1 homolog","Pkd1","Normal","PC-1, PC1, polycystin-1","MGI:97603","targeted mutation 1, Jing Zhou","Pkd1<tm1Jzh>","MGI:1857562","17",{"$nulls":15},"No",{"$nulls":12},"Perinatal lethality:* after E18.5, most mutant embryos are dead, partly absorbed or misshapen.* few homozygotes survive to term but die, on average, 4 hours after birth.Postnatal lethality:* only 1 out of 400 homozygotes survived the neonatal period and died at P8 with pale cystic kidneys and a cystic pancreas.Decreased pancreatic islet number:* homozygotes contain fewer islets of Langerhans than wild-type mice; in contrast, acini appear to develop normally.Dilated pancreatic duct:* homozygotes show early and massive dilatation of pancreatic ducts.Pancreas cysts:* homozygotes exhibit cysts in major pancreatic ducts as early as E13.5, before renal cysts develop.* newborn (and P8) pancreases contain massive yellow fluid-filled cysts that enlarge with age.Disproportionate dwarf:* at P8, the sole mutant survivor is significantly smaller relative to wild-type.* newborn homozygotess exhibit dwarfism relative to newborn wild-type mice.Distended abdomen:* homozygotes that die perinatally display distended abdomens.Hydrops fetalis:* exhibit mild hydrops fetalis at late stages of fetal developmentSkin edema:* histologically, mutant fetuses exhibit a mild subcutaneous edema.Polyhydramnios:* exhibit mild polyhydramnios at late stages of fetal development.Liver/biliary system phenotype:* unlike patients with ADPKD, homozygotes display no liver cyst formation.Renal/urinary system phenotype:* in mutants, the initial stages of lumen formation and tubule differentiation proceed normally as late as E15.5.Abnormal kidney epithelium morphology:* by P8, renal parencyma in the sole survivor is almost completely replaced by cysts; cuboidal tubular epithelia are replaced by flattened cyst-lining epithelia.Abnormal kidney medulla morphology:* at E15.5, tubular and periglomerular cysts are scattered throughout the outer medulla; nephrogenesis at the rim of the kidney remains unaffected.* cyst formation is subsequently noted in collecting tubules of the inner medulla.* in newborn homozygotes, epithelial cysts occupy the entire medulla.Enlarged kidney:* homozygotes that die perinatally exhibit massive kidney enlargement.Dilated proximal convoluted tubules:* at E15.5, homozygotes display progressive multifocal microdilatation of tubules in proximal tubules of the outer medulla.* in newborn homozygotes, tubule dilatation is more extensive, affecting most of the kidney.Kidney cysts:* homozygotes that die perinatally first exhibit tubular and periglomerular cysts at E15.5; no histological abnormalities are noted until E14.5.* the number and size of cysts increase with age.Kidney cortex cysts:* after E15.5, progressive tubule dilatation and cyst formation is noted in mutant cortex.* in newborn homozygotes, epithelial cysts occupy most of the cortex.Abnormal kidney physiology:* in culture, kidney epithelial cells isolated from E15.5 (pre-cystic) mutant mice form primary cilia but fail to increase Ca2+ influx in response to physiological fluid flow at low levels of fluid shear stress (0.75 dyne cm-2).* no Ca2+ signaling is detected in wild-type or mutant cells at higher levels of fluid shear stress (15 dyne cm-2).* both wild-type and mutant cells respond to thrombin by increasing cytosolic Ca2+ concentrations, indicating that mutant cells retain the ability to conduct Ca2+ but lose the ability to sense fluid flow.* notably, the Ca2+ response to thrombin is enhanced in mutant cells relative to wild-type cells, either in the presence of extracellular Ca2+.Abnormal thyroid cartilage morphology:* a number of newborn homozygotes exhibit thyroid cartilage malformation.Small lung:* homozygotes that die perinatally have small lungs relative to wild-type mice.Pulmonary hypoplasia:* homozygotes that die perinatally have hypoplastic lungs.Respiratory distress:* homozygotes that survive to term but die perinatally exhibit difficulty in breathing and fail to turn pink.Spina bifida occulta:* 8 out of 11 (73%) homozygotes develop mild spina bifida occulta in the lumbar region at late embryonic or newborn stages.Abnormal thyroid cartilage morphology:* a number of newborn homozygotes exhibit thyroid cartilage malformation.Chondrodystrophy:* newborn homozygotes display osteochondrodysplasiaAbnormal bone mineralization:* newborn homozygotes display a delay in bone mineralization of vertebrae, long bones and skull relative to wild-type mice.Skin edema:* histologically, mutant fetuses exhibit a mild subcutaneous edema.","Decreased pancreatic islet number:* at >20 months, few islets are present; in areas of pancreatic lipomatosis, islets appear isolated, and surrounded by mature adipocytes.Abnormal exocrine pancreas morphology:* at >20 months, heterozygotes show multiple cystic structures lined by cuboidal cyst epithelium.Abnormal pancreatic acinus morphology:* at >20 months, few acini are present; in areas of pancreatic lipomatosis, acini appear atrophic, isolated, and surrounded by mature adipocytes.Dilated pancreatic duct:* at >20 months, heterozygotes show dilatation of pancreatic ducts.Pancreas cysts:* at >20 months, 10% of heterozygotes display macroscopic pancreatic cysts; no cysts are observed at 9-20 months.* some cysts with small lumens also contain cuboidal epithelium, with a large portion of eosinophilic cytoplasm suggesting an acinar origin.Pancreas fibrosis:* at >20 months, pancreatic cystic lesions are surrounded by interstitial fibrosis.Pancreas lipomatosis:* at >20 months, the pancreas is massively replaced by adipose tissue.Abnormal bile duct morphology:* heterozygotes exhibit ductal plate malformation with occasional biliary microhamartomas.Bile duct inflammation:* in heterozygotes, impaired liver function correlates with cyst volume and cholangitis; increased cyst volume is due to increased secretion from the cystic epithelia.Dissociated hepatocytes:* heterozygotes with multiple liver cysts exhibit little residual parenchyma relative to wild-type mice.Liver cysts:* at 9-14 months of age, 4 out of 15 heterozygotes (27%) display liver cysts; notably, no liver cysts are found in perinatal homozygotes.* after 14 months of age, 7 of 8 (87%) heterozygotes have liver cysts filled with clear or dark-brown fluid (up to 10 ml in volume) occupying one- to two-thirds of the liver.* most liver cysts are lined by cuboidal or squamous biliary-like epithelium positive for cytokeratin 19 (a biliary-specific epithelial marker) and show focal hyperplasia.Decreased liver function:* in heterozygotes, cyst number and impaired liver function are associated with a significant rise in ALT, AST and LDH enzyme levels with progressive age.Renal/urinary system phenotype:* heterozygotes show no differences in kidney anatomy or histology up to 7 months of age; no renal cysts are observed at 220 days.Kidney inflammation:* in heterozygotes, large renal cysts are often surrounded by atrophic parenchyma with inflammation.Dilated renal tubules:* at 9-14 months of age, heterozygotes with renal cysts show a greater than 5-fold dilatation in tubule diameter relative to wild-type.Kidney cysts:* at 9-14 months of age, 12 out of 15 heterozygotes (80%) display 1-7 renal cysts per mouse; 5 of these mutants show bilateral cysts.* after 16 months, 100% of heterozygotes have renal cysts (2-50 per mouse); 6 of 8 heterozygotes show bilateral cysts.* most cysts fail to stain with lotus tetragonolobus lectin, a proximal tubule marker, and dolichos biflorus agglutinin, a collecting tubule marker; in contrast, glomerular cysts are common.* notably, some cysts show loss of polycystin-1 expression; in addition, EGFR is improperly localized to apical membranes in cysts and some slightly dilated tubules.* in heterozygotes, large cysts contain epithelia that range from columnar to cuboidal to squamous.Renal interstitial fibrosis:* in heterozygotes, large renal cysts are often surrounded by atrophic parenchyma with interstitial fibrosis.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[8584,"ASD538:Mrd:MrTless","B6(Cg)-Zap70<mrtle> Zap70<mur>/AnuApb","B6(Cg)-Zap70<mrtle> Zap70<mur>/AnuApb","Recessive","Zap70, zeta-chain (TCR) associated protein kinase","Zap70","Reduced","Zap-70, Srk, TZK","MGI:99613","Mr T-Less","Zap70<mrtle>","MGI:3614790","1","ENSMUSG00000026117","ENSMUST00000027291","Zap70-201","1510","1601","T to C","ENSMUSE00000230099","11","504","Tryptophan to Arginine",{"$nulls":4},"CCCGGTCTGCAGGGAAGTGGCCTCTGAAGTGGTACGCGCCAGAGTGCATCAACTTTCGGAA","No",{"$nulls":12},"Identified by severe reduction in T cell numbers in blood.B cells are normalBoth CD4⁺ and CD8⁺ T cell populations were almost completely absent in peripheral blood. Therefore, no αβ T cells but have increase in γδ T cellsNormal numbers of DN and DP T cells. Implies that have block at DP stage and mice unable to perform positive thymocyte selection.Intrinsic to T cells not microenvirnment.Cells unable to pass thymic selection steps.Cells unable to up-regulate TCRReduced signalling through TCR.Zap70 protein expression of mrt/mrt thymocytes was 25% of wildtype thymocytes.Kinase domain affected by mutation, kinase assays not performedHeterozygous mice, mrt/+ have normal levels of CD4⁺ and CD8⁺ thymocytes but Zap70 protein expression is 2 fold lower.Unlike cells devoid of ZAP-70, mrtless thymocytes showed partial induction of CD5 and CD69, and were sensitive to TCR stimulation with a dose-response shifted approximately 10-fold. However, essentially no T cells were able to compensate for the mrtless mutation and mature beyond the CD4⁺ CD8⁺ stage.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2018-10-04","Cryopreserved sperm"]
[1769,"Scl knockout 221","C57BL/6-Tal1<tm1Wehi>/Wehi",null,"Recessive","T-cell acute lymphocytic leukemia 1","Tal1","Nil","Scl, SCL/tal-1","MGI:98480","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Tal1<tm1Wehi>","MGI:1857566","4",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Embryonic lethality during organogenesis: homozygotes die by E10.5; only resorption sites with small embryonic remnants are detected at E11.5.Incomplete embryo turning: ~1/3 of homozygotes fail to complete axial rotation.Abnormal embryonic hematopoiesis:*homozygotes exhibit failure of yolk sac hematopoiesis, with no erythrocytes found in embryonic vessels.* in vitro, cultures of E8.5-E9.5 mutant yolk sacs display absence of all hematopoietic colony types.Absent vitelline blood vessels: at E8.75-E9.0, mutant yolk sacs show absence of major vitelline vessels.Absent blood islands: at E8.75-E9.0, mutant yolk sacs show absence of blood islands.Pale yolk sac: by E8.75-E9.0, mutant yolk sacs are significantly pale.Embryonic growth arrest: only a few mutant embryos develop beyond 18 somites (range 8-20).Embryonic growth retardation: homozygotes become increasingly retarded after E8.75.Distended pericardium: at E8.75-E9.0, mutant embryos exhibit dilated pericardial sacs but normal cardiac contraction.Skin edema: by E8.75-E9.0, mutant embryos are edematous.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[7378,"Yellow","SJL-ASAM<ASAM140043>",null,"Dominant","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Yellow coat colour on a white coat colour background without other associated abnormalities.","Yellow coat colour on a white coat colour background without other associated abnormalities.","SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-07-18","Cryopreserved sperm"]
[1766,null,"GATA4 KO",null,"Recessive","GATA binding protein 4","Gata4","Unknown","Gata-4","MGI:95664",{"$nulls":3},"14",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1788,"HRIpClg","B6.C-H2<bm1> Tg(Ins-CTLA4/IgFc)/Wehi",null,"Dominant",{"$nulls":25},"Mouse CTLA4 was fused to the Fc of mouse IgG2c","rat insulin promoter","High and Low clones",{"$nulls":9},"No Phenotype, except continue to excrete rotovirus longer than usual. No diabetes developes.  IMMUNOCOMPROMISED",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[311,"obese","C57BL/6-Lep<ob>",null,"Recessive","leptin","Lep","Nil",null,"MGI:104663","obese","Lep<ob>","MGI:1856424","6",{"$nulls":15},"No",{"$nulls":12},"Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan. Strain background greatly affects severity and course of diabetes.","Heterozygotes survive fasting longer than control mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03"]
[1832,"ICSBP / Blimp-1 knockout","Un-Prdm1<tm1Nutt> Irf8<tm1>/Wehi",null,"Recessive","interferon regulatory factor 8","Irf8","Unknown","ICSBP, Icsbp1, IRF-8, Myls","MGI:96395",{"$nulls":3},"8"]
[1834,"Pax5 knockout","C57BL/6-Pax5<tm1Mbu>/Wehi",null,"Recessive","paired box gene 5","Pax5","Nil","EBB-1, Pax-5","MGI:97489","paired box gene 5; targeted mutation 1, Meinrad Bussinger","Pax5<tm1Mbu>","MGI:1926938","4",{"$nulls":15},"Yes",{"$nulls":12},"Null mutants exhibit impaired development of the midbrain resulting in a reduced inferior colliculus and an altered cerebellar folial pattern, failure of B cell differentiation, runting, and high postnatal mortality with few survivors. Leg clasping phenotype when held up by the tail.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08"]
[1822,"RelA knockout Bcl-2 transgenic","C57BL/6-Rela<tm1Bal> Tg(Vav-BCL2)1Jad/Wehi",null,"Recessive","v-rel reticuloendotheliosis viral oncogene homolog A (avian)","Rela","Nil","p65, p65 NF kappaB","MGI:103290","targeted mutation 1, David Baltimore","Rela<tm1Bal>","MGI:1857270","19",{"$nulls":15},"Yes","transgene insertion 1, Jerry M Adams","hemopoiesis-specific vav promoter",{"$nulls":10},"Strain may be partially immunocompromised, due to the P65 strain.  P65 homozygous knockouts are embryonic lethal at day 15 gestation",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[1844,"Matriptase knockout","NIH Black Swiss-St14<tm1Bug>/Wehi",null,"Recessive","suppression of tumorigenicity 14 (colon carcinoma)","St14","Nil","Epithin, matriptase, MT-SP1, Prss14","MGI:1338881","targeted mutation 1, Thomas H Bugge","St14<tm1Bug>","MGI:2683707","9",{"$nulls":15},"No",{"$nulls":12},"Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within 48hrs of birth.",null,"Black Swiss","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[1836,null,"B6.CBA-Tg(CAG-cre/Esr1)5Amc",null,"Recessive",{"$nulls":25},"transgene insertion 5, Andrew P McMahon","chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer","tamoxifen inducible",{"$nulls":9},"Embryonic lethal","Normal","C57BL/6 x CBA","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08"]
[1860,"Mcl-1flox/Bak/Bax knockout","Un-Mcl1<tm3Sjk> Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3",{"$nulls":15},"Yes",{"$nulls":12},"Mcl-1 - No -/- offsrping as -/- blastocysts die at E4 prior to implanation. Therefore only +/+ and +/-  which are completely normal. Mice lacking bax display limited phenotypic abnormalities. Bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis. Those that survive are runted and grey.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[5836,"Hugo",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2800,"BPLT1","C57BL/6-C1galt1<ptl1>/Wehi",null,"Recessive","core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1","C1galt1","Unknown","core 1 beta3-Gal-T, T-synthase","MGI:2151071","ptl1","C1galt1<ptl1>","MGI:3693890","6",{"$nulls":15},"Yes",{"$nulls":12},"Premature death: by 10 weeks of age, mice become ill; 90% are moribund by 200 days.Decreased body weight: young adults (males - 15.4 grams, females - 14.4 grams) are smaller than controls (males - 24 grams, females - 18 grams).Increased blood urea nitrogen level: serum has excessive levels of urea compared to controls (169 mmol/l vs 9 mmol/l).Increased circulating creatinine level: serum has excessive levels of creatinine compared to controls( 200 mol/l vs 47 mmol/l).Proteinuria.Albuminuria: mice have high levels of albumin in urine from early ages.Kidney inflammation: kidneys show inflammatory infiltration.Glomerulonephritis: affected foci show infiltrating inflammatory cells.Abnormal renal glomerular capsule: structure is 2-4 cell layers thick compared to 1 layer in wild-type.Abnormal renal glomerulus morphology: kidneys display lesions affecting clusters of glomeruli and their proximal tubules.Cortical renal glomerulopathies: kidneys display cortical atrophy.Decreased renal glomerulus number: kidneys show glomerular loss.Abnormal proximal convoluted tubule morphology:* kidneys display lesions affecting clusters of glomeruli and their proximal tubules.* these show fatty degeneration and contain protein casts.Abnormal thrombopoiesis: generation of platelets in mutants is slower than in wild-type.Increased mean platelet volume: volume is 10.0 fl for mutant platelets compared to 8.4 fl for wild-type.Decreased platelet cell number: homozygotes have platelet counts only 40% of those in wild-type.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-02-22"]
[3445,"TCR transgenic - HNT","BALB/c-Tg(Tcra,Tcrb)1Mcd/Wehi",null,"Recessive",{"$nulls":25},"transgene insertion 1, Hugh O McDevitt",{"$nulls":11},"HNT-TCR mice express an I-A<d>-restricted TCR specific for the HA peptide 126–138 (HNTngvtaacshe). TCR transgenics immunocompromised by having mono-specific TCR however in a clean environment mice do not show a phenotype different to B6.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-17"]
[3468,"Socs6 KO","C57BL/6-Socs6<tm1Dlk>/Wehi",null,"Recessive","suppressor of cytokine signaling 6","Socs6","Nil","1500012M23Rik, 5830401B18Rik, CIS4, Cish4, HSPC060, SOCS-4, SOCS-6, Socs4, SSI4, STAI4, STAT4, STATI4","MGI:1924885","targeted mutation 1, Danielle L Krebs","Socs6<tm1Dlk>","MGI:2429394","18",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a targeted null mutation exhibit reduced body weight, but normal hematopoiesis and glucose homeostasis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22"]
[2329,"Shewag","C57BL/6-Gzma<tm1Simn> Gzmb<tm1Ley> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","granzyme B","Gzmb","Unknown","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14"]
[7314,"Epo-R-CreERT2 R26eYFP ADAR1fl/fl","C57BL/6-Epor<tm2285(Cre/ESR1)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Adar<tm1.1Phs>/SviApb",null,"Dominant","erythropoietin receptor","Epor","Nil","EpoR","MGI:95408","C57BL/6-Epor<tm2285(Cre/ESR1)Arte>","Epo-R-CreERT2",null,"9"]
[3422,"Ot-1 / SOCS1 KO / Rag1 KO","B6.129-Rag1<tm1Bal> Socs1<tm1Wehi> Tg(TcraTcrb)1100Mjb/Wehi",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848","targeted mutation 1, David Baltimore","Rag1<tm1Bal>","MGI:2448994","2"]
[3436,"relB KO (Line 272)","C57BL/6-Relb<Tg(H2-K1/GH1)106Bri>/Wehi",null,"Recessive","avian reticuloendotheliosis viral (v-rel) oncogene related B","Relb","Nil",null,"MGI:103289","avian reticuloendotheliosis viral (v-rel) oncogene related B; transgene insertion 106, Ralph L Brinster","Relb<Tg(H2-K1/GH1)106Bri>","MGI:2179544","7",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted and insertional null mutations exhibit inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, and epidermal hyperplasia. Runted, swollen abdomens. Scaly feet, ears and tails. Tight skin, hard to scruff.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16"]
[5355,"B6.303","C57BL/6-Tg(HLA DR3-DQ2)303/Apb",null,"Dominant",{"$nulls":25},"human leukocyte antigen class II",{"$nulls":11},"Expression of HLA DR and DQ evident on B cells, dendritic cells and a proportion of macrophages.Evaluation of HLA DR3-DQ2 haplotype-transgenic mice indicates regulated HLA gene expression, T cell selection and functional antigen presentation mediated by the DR and DQ genes encoded within the YAC transgene.Histological examination of tissues in transgenic mice including pancreatic B-islets did not reveal any evidence of spontaneous pathology.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","1","4",null,"No","2010-12-20","Cryopreserved sperm"]
[3486,"MMTVneu","FVB-Tg(MMTVneu)/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 202, William Muller","MMTV (mouse mammary tumor virus)",{"$nulls":10},"These mice develop tumours at approximately 6 - 8 months.   Mammary adenocarcinoma.Metastatic potential.",null,"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5256,"OsMR KO","C57BL/6-Osmr<tm1Mtan>",null,"Recessive","oncostatin M receptor","Osmr","Nil","OSMRB","MGI:1330819","oncostatin M receptor; targeted mutation 1, Minoru Tanaka","Osmr<tm1Mtan>","MGI:2680723","15",{"$nulls":15},"No",{"$nulls":12},"Hematopoietic system phenotype: * homozygotes display normal kinetics of erythrocyte recovery after acute hemolysis induced by phenylhydrazine, as determined by measuring peripheral red cells, reticulocytes, and CFU-Es in bone marrow (BM) and spleen. * in addition, homozygotes show normal kinetics of recovery of BM progenitors after 5-fluorouracil-induced myelosuppression.Abnormal hematopoiesis: homozygotes exhibit impaired hematopoiesis in the bone marrow, and increased hematopoiesis in the spleen.Abnormal common myeloid progenitor cell morphology:* in clonal culture assays, homozygotes show a significant reduction in the number of CFU-GEMMs, CFU-MEs, and BFU-Es in the bone marrow (BM) relative to wild-type mice. * in contrast to the BM, the number of CFU-GEMMs, CFU-MEs, and BFU-Es in mutant spleen is elevated relative to that observed in wild-type mice. * whereas no significant differences are observed in the number of granulocyte-macrophage colony-forming cells (GM-CFCs), including granulocyte CFUs (CFU-Gs), macrophage CFUs (CFU-Ms), and granulocyte-macrophage CFUs (CFU-GMs) in the mutant BM, the numbers of all types of GM-CFCs in mutant spleen are elevated relative to wild-type mice, indicating an opposite effect on hematopoiesis in BM and spleen. * in BM transplantation experiments, neonatal homozygotes engrafted with wild-type BM cells fail to produce erythrocytic and megakaryocytic progenitors to the levels observed in wild-type mice, indicating an effect on the hematopoietic microenvironment. * conversely, wild-type mice reconstituted with homozygous mutant BM cells exhibit a reduction in erythrocytic and megakaryocytic progenitors in the BM, whereas the GM-CFC number remains unchanged. * interestingly, hematopoietic progenitors in spleen are increased in homozygotes engrafted with either wild-type or homozygoys mutant BM cells, whereas they are not increased in wild-type mice that receive either wild-type or mutant BM cells.Abnormal erythroid progenitor cell morphology: * in clonal culture assays, homozygotes show a significant reduction in the number of CFU-Es in the BM relative to wild-type mice. * in contrast to the BM, the number of CFU-Es in mutant spleen is significantly increased relative to that observed in wild-type mice.Decreased erythrocyte cell number:  * homozygotes show a significant reduction in the mean number of peripheral erythrocytes relative to wild-type mice (894 ± 64 x 104/mL vs 1028 ± 52 x 104/mL, respectively). * in contrast, the mean number of peripheral white blood cells remains relatively unaffected.Decreased hematocrit: homozygotes display a reduced hematocrit relative to wild-type mice.Anemia: homozygotes are slightly anemic relative to wild-type mice.Decreased platelet cell number: homozygotes show a significant reduction in the mean number of peripheral platelets relative to wild-type mice (82 ± 10 x 104/mL vs 106 ± 15 x 104/mL, respectively).Abnormal megakaryocyte progenitor cell morphology: homozygotes show a significant reduction in the number of megakaryocyte progenitors, as determined in liquid cultures of BM cells.Decreased megakaryocyte cell number: homozygotes show a significant reduction in the number of mature megakaryocytes in the BM relative to wild-type mice, as measured in H&E stained femoral sections.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-21"]
[2762,"BALB/c.Flii 1.4A","BALB/c-Flii<tm1Hdc>/2AnuApb","BALB/c-Flii<tm1Hdc>/2AnuApb","Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethality at implantation: no embryos are recovered after E5.5; embryos develop normally until cellularization, the development arrests before completion of gastrulation blastocysts initiate uterine implantation but embryos fail to develop. embryonic growth arrest: development arrests during gastrulation","Enhanced wound healing: 3 days after a 1 cm full-thickness incision was made in the dorsal skin, surface wound area measurements show smaller, more contracted wounds than in wild-type mice. Length of neoepidermis is significantly greater in mutant animals, and percentage or re-epithelialization of wounds is greater at 5 days after wounding. By day 7, healing is comparable in mutants and wild-type","BALB/c","No","No","Yes","No","No","Yes","No","Poor","10","11","Het male x WT female","No","2008-02-14","Cryopreserved sperm"]
[6837,"Gpc1 knockout","B6;CD-1-Gpc1<tm1.1Alan>/Apb",null,"Dominant","glypican 1","Gpc1","Nil",null,"MGI:1194891","glypican 1; targeted mutation 1.1, Arthur Lander","Gpc1<tm1.1Alan>","MGI:3774029","1",{"$nulls":28},"Lifespan, fertility and health are normal. Occasional malocclusions. Brain may be slightly smaller than normal.","Unknown","C57BL/6 x CD-1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-03-06","Cryopreserved sperm"]
[8489,"NOD.Nkrp1b.Art2b","NOD-Klrb1b<C57BL/6> Art2b<tm1Fkn>/BaxApb",null,"Recessive","ADP-ribosyltransferase 2b","Art2b",null,"ART2.2, Rt6, Rt-6, Rt6-2","MGI:107545","ADP-ribosyltransferase 2b; targeted mutation 1, Friedrich Koch-Nolte","Art2b<tm1Fkn>","MGI:2388827","7",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2018-05-31","Cryopreserved sperm"]
[3526,null,"NOD.B6 Idd9/11",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 9; C57BL/6J","Idd9<C57BL/6>","MGI:3036801","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[7739,"Pax5-Exon 8","C57BL/6NJAnu-Pax5<m3Anu>/AnuApb",null,"Recessive","paired box 5","Pax5",null,"EBB-1, Pax-5","MGI:97489",{"$nulls":3},"4",{"$nulls":28},"B cell",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-09-12","Cryopreserved sperm"]
[5266,"OsxCre/RARalphaRARgamma","C57BL/6-Rara<tm3lpc> Rarg<tm3lpc> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc",null,"Recessive","retinoic acid receptor, gamma","Rarg","Normal","RAR gamma 2, RARgamma2","MGI:97858","retinoic acid receptor, gamma; targeted mutation 3, Pierre Chambon","Rarg<tm3Ipc>","MGI:2386111","15",{"$nulls":15},"Yes"]
[6839,"APN 222","C57Bl/6N-mir-196a-1<puDtk(Wtsi)>/MarpApb",null,"Recessive","microRNA 196a-1","Mir196a-1","Unknown","Mirn196, Mirn196a-1, mmu-mir-196a-1","MGI:2676860",{"$nulls":3},"11",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-03-08","Cryopreserved sperm"]
[7740,"SB12","STOCK Gt(ROSA)26Sor<tm2(sb11)Njen> TgTn(sb-T2/Onc3)12775Njen/Nci",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Nancy A Jenkins","Gt(ROSA)26Sor<tm2(sb11)Njen>","MGI:3839796","6",{"$nulls":16},"transgenic transposon concatemer 12775, Nancy A Jenkins","CAG promoter ",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Poor",{"$nulls":3},"No","2014-09-15","Cryopreserved sperm"]
[4934,"Cathepsin-S Knockout","SJL-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-24"]
[1959,"available from Animal Resources Centre - www.arc.wa.gov.au","C3H/HeJ",null,"Dominant","Inbred agouti: A, Pde6b<rd1>, H-2<k>",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No",{"$nulls":12},"General Information: Typically C3H/HeJ are unresponsive to lipopolysaccharide due to a B-cell deficit. (Anderson and Ostermann (1980). LPS responsiveness of C3H substrains. Acta virol. 24:294-296).",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"Yes","2007-09-04"]
[5366,"RIP7-Socs1","C57BL/6-Tg(Ins2-Socs1)21Wehi",null,"Dominant",{"$nulls":25},"suppressor of cytokine signaling-1","rat insulin promoter 2 (RIP7)",{"$nulls":10},"SOCS-1 overexpression inhibits β cell responsiveness to IFNs.SOCS-1 overexpression in β cells prevents progression to diabetes in CD8<+>TCR transgenic NOD8.3 mice.Transgenic mice develop massive insulitis.SOCS-1 overexpression prevents the induction of Fas expression on β cells in NOD8.3 mice and in response to TNF and IFN-γ.Cells isolated from transgenic mice have a reduced ability to stimulate 8.3 T cell proliferation and IFN-γ production.SOCS-1 overexpression suppresses islet expression of IL-15 in response to TNF and IFN-γ.β cell up-regulation of Fas and class I MHC expression in mice adoptively transferred with diabetogenic splenocytes is also prevented by SOCS-1 overexpression.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[7097,"DMP-cre","C57BL/6-Tg(Dmp1-cre)1Jqfe/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Jian Q Feng","dentin matrix protein 1 (Dmp1)","Cre expression restricted to dontoblasts and osteocytes",{"$nulls":9},"Normal.Cre expression in odontoblasts and osteocytes","Normal.Cre expression in odontoblasts and osteocytes","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-09-28","Cryopreserved sperm"]
[8496,"NOD.Il10-/-","NOD.Cg-Il10<tm1Cgn>/BaxApb",null,"Recessive","interleukin 10","Il10",null,"cytokine synthesis inhibitory factor, IL-10","MGI:96537","interleukin 10; targeted mutation 1, University of Cologne","Il10<tm1Cgn>","MGI:1857199","1",{"$nulls":28},"This mutant develops type 1 diabetes at the same rate as the NOD/Lt parental strain. The Il10 tm1Cgn mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.Large intestinal inflammation:\t• mutants develop severe inflammation in the colon leading to inflammatory bowel disease Abnormal regulatory T cell physiology:\t• CD25-positive CD4 T cells from these mice fail to protect against the wasting disease induced by transferring nave CD4 T cells into immunodeficient hosts","Unknown","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-05-31","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[5264,"RARgamma/TNFalpha","C57BL/6-Rarg<tm1Ipc> Tnf<Gkl>",null,"Recessive","retinoic acid receptor, gamma","Rarg","Nil","MGC:11555, MGC:18523, RAR gamma 2, RARgamma2","MGI:97858","retinoic acid receptor, gamma; targeted mutation 1, Pierre Chambon","Rarg<tm1Ipc>","MGI:1931079","15",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-21"]
[7742,"ENU19:B6:MRPS34","C57BL/6JAnu-Mrps34<m1Anu>/AnuApb",null,"Recessive","mitochondrial ribosomal protein S34","Mrps34","Unknown","0610007F04Rik, 5330430D13Rik, Tce2 ","MGI:1930188 ",{"$nulls":3},"17","ENSMUSG00000038880","ENSMUST00000043907","Mrps34-001","203","252","T to C","ENSMUSE00000747863","1","68","Leucine to Proline",{"$nulls":18},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","mut x mut","No","2014-09-23","Cryopreserved sperm"]
[4938,"Crlf1 KO","C57BL/6-Crlf1<tm1Wsa>/Wehi",null,"Recessive","cytokine receptor-like factor 1","Crlf1","Nil","CLF-1, CRLM3, cytokine receptor like molecule 3, NR6.1","MGI:1340030","targeted mutation 1, Warren S Alexander","Crlf1<tm1Wsa>","MGI:2387956","8",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.Neonatal lethality: at birth, homozygotes are present at the expected Mendelian frequency; however, no homozygotes survive beyond 24 hrs after birth.Absent gastric milk in neonates: newborn homozygotes contain no milk in their stomachs.Abnormal suckling behavior: newborn homozygotes open and close their mouths but fail to suckle effectively, despite the absence of gross or histologic abnormalities in brain (i.e. cortex and hippocampus), olfactory bulb, as well as facial or mouth tissues.Decreased motor neuron number:* newborn homozygotes display a significantly reduced number of motoneurons in the lumbar spinal cord, with no apparent change in the brachial or thoracic cord.* newborn homozygotes also exhibit a significant decrease in the number of motoneurons in the facial but not hypoglossal nucleus; sensory neurons of the dorsal root ganglia remain unaffected.Impaired hematopoiesis:* newborn homozygotes display reduced numbers of hemopoietic progenitor cells in the bone marrow and spleen* no differences in the numbers and lineage commitment of progenitor cells are observed in neonatal liver.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-12-01"]
[7743,"ENU23:005:MRPL44","C57BL/6NCrlAnu-Mrpl44<m1Anu>/AnuApb",null,"Recessive","mitochondrial ribosomal protein L44","Mrpl44 ","Unknown","1810030E18Rik, 5730593H20Rik","MGI:1916413 ",{"$nulls":3},"1","ENSMUSG00000026248","ENSMUST00000027464","Mrpl44-001","868","983","C to T","ENSMUSE00000356749","4","290","Leucine to Phenylalanine",{"$nulls":18},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7","het x het","No","2014-09-23","Cryopreserved sperm"]
[2773,"BALB/c.Flii<-/-> FLII<c17.8/c17.8> ; FITR","BALB/c-Flii<tm1Hdc> Tg(FLII)2Hdc/AnuApb","BALB/c-Flii<tm1Hdc> Tg(FLII)2Hdc","Recessive","flightless I homolog (Drosophila)","Flii","Unknown","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes","Human Flightless gene","Human Flightless",{"$nulls":10},"Embryonic lethal phenotype of FLii knockout is rescued by human FLII transgene. ",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","1",null,"Flii<-/-> FLII<c17.8/c17.8> x Flii<-/-> FLII<c17.8/c17.8>","No","2008-02-16","Cryopreserved sperm"]
[278,"R-double","129-Ifnar<tm1Agt> Ifngr<tm1Agt>/Apb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, Ifngr, INF-g receptor, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10"]
[8500,"ASD797:Persimmon:10","C57BL/6NCrlAnu-Ifit3b<em1Anu>/AnuApb",null,"Recessive","interferon-induced protein with tetratricopeptide repeats 3B","Ifit3b","Unknown","I830012O16Rik","MGI:3698419",{"$nulls":3},"19",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-05","Cryopreserved sperm"]
[5865,"K14E7.FVB",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8502,"ASD798:Sapote:4","C57BL/6NCrlAnu-Ifit3<em1Anu> Ifit3b<em3Anu>/AnuApb",null,"Recessive","interferon-induced protein with tetratricopeptide repeats 3","Ifit3","Unknown","Ifi49","MGI:1101055",{"$nulls":3},"19"]
[4826,"Huon","ENU8CAT:069",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[8503,"ASD798:Sapote:8","C57BL/6NCrlAnu-Ifit3<em2Anu>/AnuApb",null,"Recessive","interferon-induced protein with tetratricopeptide repeats 3","Ifit3","Unknown","Ifi49","MGI:1101055",{"$nulls":3},"19",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-05","Cryopreserved sperm"]
[7557,"ENU27:002:PIK3IP1:B6","C57BL/6NCrlAnu-Pik3ip1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Pik3ip1<m1Anu>/AnuApb","Recessive","phosphoinositide-3-kinase interacting protein 1","Pik3ip1","Unknown","1500004A08Rik, 5830455E04Rik","MGI:1917016","phosphoinositide-3-kinase interacting protein 1; mutation 1, The Australian National University","Pik3ip1<m1Anu>","MGI:5563439","11","ENSMUSG00000034614","ENSMUST00000045153","Pik3ip1-001","313","847","A to G","ENSMUSE00000314294","4","105","Serine to Alanine",{"$nulls":4},"CCTGCGAGGACGTGAGTTGCCCAGAGACCACTTCCCAAGCACCACCGCCATCCTCTGCCAT",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-12-19","Cryopreserved sperm"]
[5368,"NOD.Bid","NOD;129S1(B6)-Bid<tm1.1Ast>",null,"Recessive","BH3 interacting domain death agonist","Bid","Nil",null,"MGI:108093","BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser","Bid<tm1.1Ast>","MGI:4440571","6",{"$nulls":15},"No",{"$nulls":12},"Decreased sensitivity to induced morbidity/mortality: * unlike wild-type mice that die from fatal hepatitis within 3?4 hr of anti-Fas antibody treatment, all mutants survive. * homozygous mice develop and age normally and have no increased incidence of tumor development. * cell subset composition and total cellularity of thymus, spleen, and lymph nodes were normal.Cellular phenotype: unlike other reports, hematopoietic cell and fibroblasts from homozygous mice are normally sensitive to apoptotic stimuli including DNA damage and gamma-irradiation or treatment with etoposide.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21"]
[5448,"Idd14 R11","NOD.B6-Idd14 R11",null,"Recessive",{"$nulls":37},"Unknown","Unknown","NOD/Lt","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"Yes","2011-03-01","Cryopreserved sperm"]
[7747,"ENU33:G2","ANU:ENU33:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-10-02","Cryopreserved sperm"]
[7560,null,"SJL/Mrit-MRI28562","SJL/Mrit-MRI28562","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a slight decrease growth phenotype","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-01-07","Cryopreserved sperm"]
[4188,"(SOCS1/RIP)","B6.Cg-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Ins2-cre)25Mgn/Apb",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","suppressor of cytokine signaling 1","Socs1<tm1Wehi>","MGI:1934607","16",{"$nulls":15},"Yes","transgene insertion 25, Mark A Magnuson ","rat insulin promoter 2",{"$nulls":10},"Mice with SOCS1 targeted mutation in beta cells develop normally.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"12","Heterozygous For Cre transgene (T/+) and for SOCS1c with SOCS1 KO (fl/-)","No","2008-12-19","Cryopreserved sperm"]
[4188,"(SOCS1/RIP)","B6.Cg-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Ins2-cre)25Mgn/Apb",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Unknown","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research","Socs1<tm3Wehi>","MGI:2656917","16",{"$nulls":15},"No"]
[7381,"Dicer","B6.129-Dicer1<tm1Bdh>/WehiAnuApb",null,"Recessive","dicer 1, ribonuclease type III","Dicer1",null,null,"MGI:2177178","dicer 1, ribonuclease type III; targeted mutation 1, Brian D Harfe","Dicer1<tm1Bdh>","MGI:3589208","12",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-25","Cryopreserved sperm"]
[4855,"Piaf","ENU7B6:022:B10BR",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Ataxia",null,"C57BL/6 x C57BL/10BR","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[8508,"NOD.Nkrplb.Slam1A","NOD.Nkrplb.Slam1A",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2018-06-08","Cryopreserved sperm"]
[8508,"NOD.Nkrplb.Slam1A","NOD.Nkrplb.Slam1A",null,"Recessive",{"$nulls":28},"slam1a",{"$nulls":7},"Unknown","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2018-06-08","Cryopreserved sperm"]
[4893,"Phenomix","Phx",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2009-09-30","Cryopreserved sperm"]
[8510,"NOD.H2b.Nkrplb.CD-1","NOD.H2b.Nkrplb.CD-1",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Difficult breeders. Have had to restart the breeding, multiple times due to the difficulty in getting them homozygous. Seems homozygous mice do not breed. Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.Knockout lacking the CD1 antigen complex gene",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2018-06-08","Cryopreserved sperm"]
[8563,"MMP-9","BALB/c-Mmp9<tm1>/OnjcriApb",null,"Recessive","matrix metallopeptidase 9","Mmp9","Unknown","B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9","MGI:97011",{"$nulls":3},"2",{"$nulls":28},"MMP-9 null mice have a very mild bone phenotype (lengthening of the growth plates) that tends to normalize with age. ","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-18","Cryopreserved sperm"]
[5046,"KRN14","KRN:014",null,"Recessive","glutamate receptor, ionotropic, kainate 4","Grik4","Unknown","GluRgamma1, KA-1, KA1","MGI:95817",{"$nulls":3},"9",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis, no GPI autoantibodies in KRN/H2g7 model.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-02-26","Cryopreserved sperm"]
[5276,"NOD-NGL","NOD-Tg(NFkB-eGFP/Luc)Het",null,"Dominant",{"$nulls":25},"enhanced green fluorescent protein + luciferase","nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 ; NFkB",{"$nulls":10},"Unknown",null,"NOD/Lt x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[5275,"NODTG950 ; NOD.B6-TgN(HUSOD1-HUSOD3-HUGPX-MUSMHH2KB)1Lt/J","NOD;B6-Tg(H2-K-GPX1,-SOD1,-SOD3/CD55)CCpj",null,"Dominant",{"$nulls":25},"human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag","H2-K<b>",{"$nulls":10},"Expression of all three enzymes was the only combination protective against hypoxia/reoxygenation. In contrast to single- and double-transgenic grafts, triple-transgenic grafts significantly improved control of blood glucose compared with wild type. ",null,"NOD/Lt x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-26"]
[712,"NR4MD4","NOD.NOR-(D4Mit31-D4Mit310) Tg(IghelMD4)4Ccg",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow",null,"High"]
[5895,"Ly6E",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8565,"ASD948:PKR 1bp ins:EIF2AK2","C57BL/6NCrlAnu-Eif2ak2<em1Anu>/AnuApb",null,"Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Unknown","2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-20","Cryopreserved sperm"]
[8567,"PKR 8bp del:EIF2AK2","C57BL/6NCrlAnu-Eif2ak2<em3Anu>/AnuApb",null,"Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Unknown","2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-21","Cryopreserved sperm"]
[1958,"available from Animal Resources Centre - www.arc.wa.gov.au","BALB/cArc",null,"Dominant","Inbred albino: Tyrc, Tyrp1b, A, H-2d",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No",{"$nulls":12},"Good breeding performance, 0.75 young/female/wk., average litter 5.5. Long breeding life. Relatively robust and moderate life span (males and females 20 months). Low incidence of mammary tumours. Amyloidosis (40%) in older males. BALB/c mice can have high blood pressure; left auricular thrombosis and mineralisation common (66%) in older breeding females. Slightly aggressive. High social dominance exhibited by males in presence of females resulting in high aggression. Commonly used for ascites fluid production. Injection of mineral oil IP induces high incidence of transplantable plasmacytomas. Low mortality after neonatal thymectomy. Normal C5.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"Yes","2007-09-04"]
[8568,"ASD801:TgPKR","B6(Cg)-Tg(Vav1-EIF2AK2)#Wsmay/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion, W May","vav1",{"$nulls":11},"peripheral blood counts from TgPKR mice decrease with age in association with dysplastic marrow changes. TgPKR mice have reduced colony-forming capacity and the colonies also are more sensitive to hematopoietic stresses. Furthermore, TgPKR mice have fewer hematopoietic stem/progenitor cells (HSPCs), and the percentage of quiescent (G0) HSPCs is increased. Importantly, treatment of TgPKR bone marrow (BM) with a PKR inhibitor specifically rescues sensitivity to growth factor deprivation. In contrast, marrow from PKR knockout (PKRKO) mice has increased potential for colony formation and HSPCs are more actively proliferating and resistant to stress. Significantly, TgPKR HSPCs have increased expression of p21 and IFN regulatory factor, whereas cells from PKRKO mice display mechanisms indicative of proliferation such as reduced eukaryotic initiation factor 2α phosphorylation, increased extracellular signal-regulated protein kinases 1 and 2 phosphorylation, and increased CDK2 expression.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-21"]
[5485,"ENU18FLT3-ITD:G2 #58","ENU18FLT3-ITD:G2",null,"Dominant","FMS-like tyrosine kinase 3","Flt3","Increased","CD135, Flk-2, Flk2, Flt-3","MGI:95559","FMS-like tyrosine kinase 3; targeted mutation 1, D Gilliland","Flt3<tm1Dgg>","MGI:3763385","5",{"$nulls":15},"Yes",{"$nulls":12},"Accelerated onset of Acute Myeloid leukaemia.","Accelerated onset of Acute Myeloid leukaemia.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"G2",null,"No","2011-04-19","Cryopreserved sperm"]
[8518,"Rab32.3","C57BL/6-Rab32<tm1>",null,"Recessive","RAB32, member RAS oncogene family","Rab32","Nil","2810011A17Rik","MGI:1915094",{"$nulls":3},"10",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-14"]
[1826,"Blimp1 knockout","C57BL/6-Prdm1<tm1Nutt>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes",{"$nulls":12},"Prenatal lethality: homozygotes die late in gestation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[3519,null,"Balb/c.C57BL/6-Lmr1 <BALB/c>Lmr2<BALB/c>",null,"Recessive","leishmaniasis resistance 2","Lmr2","Unknown",null,"MGI:1277141","leishmaniasis resistance 2; BALB/c ","Lmr2<BALB/c>","MGI:2446906","9"]
[7756,"Confetti","B6.129P2-Gt(ROSA)26Sor<tm1(CAG-Brainbow2.1)Cle>/J",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","targeted mutation 1, Hans Clevers","Gt(ROSA)26Sor<tm1(CAG-Brainbow2.1)Cle>",null,"6",{"$nulls":28},"Mice homozygous for the R26R-Confetti conditional allele are viable and fertile, with a CAG promoter, loxP site, and STOP cassette preventing transcription of the downstream Brainbow 2.1 sequences.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09"]
[7565,"ENU27:020:Katnal2:B6","C57BL/6NCrlAnu-Katnal2<m1Anu>/AnuApb",null,"Recessive","Katanin p60 subunit A-like 2","Katnal2","Unknown","3110023G01Rik, 4933439B08Rik","MGI:1924234",{"$nulls":3},"18","ENSMUSG00000025420","ENSMUST00000026486","Katnal2-005","257","329","T to C","ENSMUSE00001268471","3","86","Tyrosine to Cysteine",{"$nulls":4},"GAGCTATTATTTTGTAAAGTTCCAGAAGTACCCCAAAGTGGTTAAGAAGGCCCCGGACCCA",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","No","Yes","Yes","Unknown",{"$nulls":3},"No","2014-01-14","Cryopreserved sperm"]
[7293,"B6/J - Blue G18","C57BL/6JAnu-redev-BlueG18",null,"Dominant",{"$nulls":39},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-03-21","Cryopreserved sperm"]
[7112,"ENU22:Stxbp2","C57BL/6NCrlAnu-Stxbp2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Stxbp2<m1Anu>/AnuApb","Recessive","syntaxin binding protein 2","Stxbp2","Unknown","C79054, Munc-18-2, Munc18b, Munc-18b, muSec1, Sxtp2 ","MGI:107370","syntaxin binding protein 2; mutation 1, The Australian National University","Stxbp2<m1Anu>","MGI:5563406","8","ENSMUSG00000004626","ENSMUST00000160708","Stxbp2-001",{"$nulls":7},"3636354","11",null,null,"ACGATCTCTACCCTCTCCTACCATTACCTCAGGCCAACATCAAAGACCTGTCCCACATCC",{"$nulls":13},"Reduced fusion of cytolytic granules with cell membrane","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","none","3","het x het","No","2012-10-24","Cryopreserved sperm"]
[7757,"MMTV/cre","STOCK Tg(MMTV-cre)1Mam/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion, Lothar Hennighausen","mouse mammary tumor virus (MMTV) long terminal repeat","secretory epithelium of the mammary gland, the salivary gland and in the female germline",{"$nulls":9},"This transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. The MMTV LTR promoter directs a widespread pattern of expression including the female germline.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09"]
[6638,"Circling ; ENU18PiDTau_ TBx1","STOCK Tbx1<enu37> Tg(Thy1-MAPT*K369I)K3Gotz/AnuApb",null,"Dominant","T-box 1","Tbx1",null,null,"MGI:98493","T-box 1; enu37","Tbx1<enu37>","MGI:5490246","16",{"$nulls":16},"transgene insertion K3, Jurgen Gotz","Thy1","neuron specific",{"$nulls":9},"Unknown","Head tilt:• head tilting and weavingBidirectional circling","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2011-11-02","Cryopreserved sperm"]
[7383,"ENU28:G2","ANU:ENU28:G2",null,"Recessive",{"$nulls":37},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2013-07-26","Cryopreserved sperm"]
[3592,"Fasl-gld","B6.C3-Fasl<gld>/AnuApb","B6.C3-Fasl<gld>","Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Unknown","APT1LG1, CD178, CD95L, Fas-L, Tnfsf6","MGI:99255","generalized lymphoproliferative disease","Fasl<gld>","MGI:1856384","1",{"$nulls":15},"Yes",{"$nulls":12},"Increased peripheral blood lymphocyte number. Increased T cell number. Increased neutrophil number. Abnormal T cell differentiation. Decreased B cell numbers. Anemia. Premature death - animals die around 60 weeks. Splenomegaly, lymphoadenopathy.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06","Cryopreserved sperm"]
[8524,null,"C57BL/6N-Abca12<tm1a(EUCOMM)Hmgu>/MarpApb",null,"Recessive","ATP-binding cassette, sub-family A (ABC1), member 12","Abca12","Unknown","4832428G11Rik, 4833417A11Rik","MGI:2676312","ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Abca12<tm1a(EUCOMM)Hmgu>","MGI:4941545","1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-18","Cryopreserved sperm"]
[7102,"ENU23:008:P2RX5:B6","C57BL/6NCrlAnu-P2rx5<m1Anu>/AnuApb",null,"Recessive","purinergic receptor P2X, ligand-gated ion channel, 5","P2rx5","Unknown","P2X5","MGI:2137026",{"$nulls":3},"11","ENSMUSG00000005950","ENSMUST00000006104","P2rx5-001",{"$nulls":7},"73167492","7",null,null,"ACTCTAGCATTCATCCTGTCTTATGTATCAAGGGCGGTGTGATAGGAATCCACATTGAAT",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-10-05"]
[3316,"FATT-C57","C57BL/6-Lepr<FATT>/Apb",null,"Recessive","Leptin Receptor","LepR","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, OB-RGRP, obese-like, obl, Obr","MGI:104993","FATT","Lepr<FATT>",null,"4",{"$nulls":15},"Yes",{"$nulls":12},"The homozygote mutant has juvenile obesity, florid diabetes. The adult is hypogonadal and does not breed, and had an increased body length (10-20%).","There is a slight change in adipose tissue distribution and liver weight but no other significant changes. ","129Sv/EvTac x C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Good","4",null,"Heterozygous FATT-C57/BL6 mice crossed with C57/BL6 working towards a C57/BL6 background. Homozygous mutants are not fertile/do not breed. ","No","2008-06-09","Cryopreserved sperm"]
[7372,"ENU26:047:Trpv4:B6:G2","C57BL/6NCrlAnu-Trpv4<m1Anu>/AnuApb",null,"Recessive","transient receptor potential cation channel, subfamily V, member 4","Trpv4","Unknown","0610033B08Rik, OTRPC4, Trp12, VRL-2, VROAC, VR-OAC","MGI:1926945","mutation 1, The Australian National University","Trpv4<m1Au>",null,"5","ENSMUSG00000014158","ENSMUST00000071968","Trpv4-001","1859","1970","A to G","ENSMUSE00001210261","12","620","Valine to Alanine",{"$nulls":4},"CTTCAAAGACCTCTTCCGCTTCCTGCTTGTGTACCTGCTCTTCATGATCGGCTATGCCTCA",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-05"]
[4190,null,"NOD.B6-Prf1<tm1Sdz>/J",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Unknown","perforin, Pfn, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":15},"No",{"$nulls":12},"Type 1 diabetes incidence was decreased from 77% in wildtype females to 16% in homozygotes. The onset of disease was also delayed from a median of 19 weeks to 39.5 weeks of age.","Mice develop Type 1 diabetes with reduced incidence compared to NOD/Lt control or littermate control mice. Phenotype is intermediate.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","9",null,"Sib x Sib","No","2008-12-19"]
[7928,"S6<fl> Mx1-Cre","B6(Cg).129-Rps6<tm1Gtho> Tg(Mx1-Cre)1Cgn/JAnu",null,"Recessive","ribosomal protein S6","Rps6","Normal","S6R","MGI:98159","ribosomal protein S6; targeted mutation 1, George Thomas","Rps6<tm1Gtho>","MGI:2387471","4",{"$nulls":16},"transgene insertion 1, University of Cologne","Mx1",{"$nulls":10},"Abnormal cell morphology:• mice induced with interferon gamma exhibited similar responses to starvation as controls, although it was noted that 40S ribosomes were absent and 60S ribosomes were increased in number in mutant liver recovering from starvationAbnormal cell cycle• xpression of cell cycle markers such as cyclin E and cyclin A were not seen in mutant hepatocytes suggesting a block in cell cycle progressionDecreased liver regeneration:• after partial hepatectomy, mutant liver failed to regenerate after 10 days; histopathology revealed no evidence of regenerative or pathological processes in mutant liver; expression of cell cycle markers such as cyclin E and cyclin A were not seen in mutants suggesting a block in cell cycle progression",null,"C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm"]
[5543,"ENU14Yaa:032b","B6.SB-Lyn<m2Anu>/AnuApb","B6.SB-Lyn<m2Anu>/AnuApb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn",null,"Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; mutation 2, The Australian National University","Lyn<m2Anu>","MGI:5563397","4","ENSMUSG00000042228","ENSMUST00000041377","Lyn-001",{"$nulls":7},"3683632","9",null,null,"CTACATCATCACCGAGTTCATGGCTAAGGGTGAGTGGCATCACGAGTCTGTACCCCTAAA",{"$nulls":13},"Increased % immature B cells, and reduced % mature B cells (Almost no Mature B cells)",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-07-27","Cryopreserved sperm"]
[7763,"B6-H2k","B6.AK-H2<k>/FlaEgJAusb","B6.AK-H2<k>/FlaEgJAusb","Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.",null,"C57BL/6JFlaEg","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-12"]
[8527,"ASD778:Lrrfip1","C57BL/6NCrlAnu-Lrrfip1<em1Anu>/AnuApb",null,"Recessive","leucine rich repeat (in FLII) interacting protein 1","Lrrfip1","Unknown","FLAP (FLI LRR associated protein), Fliiap1","MGI:1342770",{"$nulls":3},"1",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-06-27","Cryopreserved sperm"]
[7298,"Il7Tg:Thy1.1","B6.Cg-Thy1<a> Tg(H2-Ea-Il7)10Rhdr/ScrAusbAnu",null,"Recessive","thymus cell antigen 1, theta","Thy1",null,"CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":16},"transgene insertion 10, Rhodri Ceredig","H2-Ea promoter",{"$nulls":10},"No B cells",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-03-22","Cryopreserved sperm"]
[8528,"17NF","B6.Cg-Tg(Cyp17a1-NGF)2456Oje/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 2456, Sergio R Ojeda","17alpha-hydroxylase promoter","thecal-interstitial cells",{"$nulls":9},"Polycystic ovary disease",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-06-29","Cryopreserved sperm"]
[5091,"APP23/Tau KO","C57BL/6-Tg(Thy1-APP)3Somm Mapt<tm1(EGFP)Klt>",null,"Recessive","microtubule-associated protein tau","Mapt","Nil","Mtapt, Tau","MGI:97180","microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker","Mapt<tm1(EGFP)Klt>","MGI:2670768","11",{"$nulls":16},"transgene insertion 3, Bernd Sommer","mouse Thy1","Highest levels of transgene expression in the neocortex and hippocampus",{"$nulls":9},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-04-15"]
[7766,"Scl-flox","C57BL/6-Sost<flox>/Ausb",null,"Recessive","sclerostin","Sost","Unknown","5430411E23Rik","MGI:1921749",{"$nulls":3},"11",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-12"]
[8588,"MDX:PAR2","B6.B10-Dmd<mdx> F2rl1<tm1Cgh>/Apb",null,"Recessive","dystrophin, muscular dystrophy","Dmd",null,"Dp427, Dp71, Duchenne muscular dystrophy, dys, mdx, pke, X-linked muscular dystrophy","MGI:94909","mdx & F2rl1","dystrophin, muscular dystrophy; X linked muscular dystrophy","Dmd<mdx>","X",{"$nulls":28},"Dystrophic (mdx)PAR2 deficiency","Normal","C57BL/6 ; C57BL/10","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-10-17","Cryopreserved sperm"]
[3546,null,"B6.D2-Kitl<Sl-d>/JWehi",null,"Semi-dominant","kit ligand","Kitl","Normal","Gb, grizzle-belly, Mgf, SF, Sl, SLF, Steel, Steel factor, stem cell factor","MGI:96974","kit ligand; steel Dickie ","Kitl<Sl-d>","MGI:1856164","10",{"$nulls":15},"No",{"$nulls":12},"Anaemic, Light Coat, White Spotting  Maximal severity of phenotype according to age (pre-weaning): E13 - wean  Homozygotes will be black-eyed whites and die between E13 and Weaning.  Although homozygous Kitl<Sl-d>/Kitl<SL-d> have been described as being viable, Dr. Jane Barker of The Jackson Laboratory has found that in her colony B6.D2-Kitl<Sl-d> homozygotes die at birth or soon thereafter.  ",null,"C57BL/6 x DBA/2","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-30"]
[7768,"ONCtgN","C57BL/6-Tg(Bglap)/Ausb",null,"Dominant",{"$nulls":25},"bone gamma carboxyglutamate protein",{"$nulls":11},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-12"]
[3527,null,"C57BL/6-Socs3<tm1Wsa>/Socs3<tm2Wsa> Tg(Vav1-cre)1Awr/0",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Unknown","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 1, Warren S Alexander ","Socs3<tm1Wsa>","MGI:2180861","11",{"$nulls":15},"Yes","transgene insertion 1, Andrew W Roberts  ","Vav1",{"$nulls":10},"Deletion of Socs3 in all haemopoietic cells and endothelial cells. Increased neutrophil cell number - enhanced by injection with CSF3 (G-CSF), which also induced progenitor cell mobilization, splenomegaly, and inflammatory neutrophil infiltration into multiple tissues resulting in partial hind leg paralysis.  Increased inflammatory response - evident by 17 weeks of age and characterized by inflammation in the pleural and peritoneal cavities and infiltration of hematopoietic cells into the liver and lungs.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[7300,"B6/JAnu-redev - Purple G19","C57BL/6JAnu-redev-PurpleG19",null,"Dominant",{"$nulls":39},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-03-28","Cryopreserved sperm"]
[3578,null,"C57BL/6-Tg(RIP-Ova<lo>) Bcl2l11<tm1.1Ast>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Unknown","1500006F24Rik, Bim, Bod","MGI:1197519","targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"Yes","Chicken Ovalbumin","rat insulin 2","Low",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04"]
[3580,null,"BALB/c-Tg(CIITA)",null,"Recessive",{"$nulls":25},"class II transactivator (CIITA)",{"$nulls":13},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04"]
[7573,"37L1lacZ","C57BL/6N-A<tm1Brd> Gpr37L1<tm1b(EUCOMM)Wtsi>/Apb",null,"Dominant","G protein-coupled receptor 37-like 1","Gpr37l1","Unknown","CAG-18, D0Kist8","MGI:1928503",{"$nulls":3},"1",{"$nulls":28},"Unknown. Reporter mouse with gene deletion.","Unknown. Reporter mouse with gene deletion.","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","Pure background",null,"het x het","No","2014-01-20","Cryopreserved sperm"]
[7574,"37L1KO","C57BL/6-Gpr37L1<tm1d(EUCOMM)Wtsi>/NsmitApb",null,"Recessive","G protein-coupled receptor 37-like 1","Gpr37l1","Reduced","CAG-18, D0Kist8","MGI:1928503",{"$nulls":3},"1",{"$nulls":28},"deletion of GPR37L1 causes a female-specific increase in systolic, diastolic, and mean arterial pressures.When challenged with short-term AngII infusion, only male GPR37L1 KO/KO mice developed exacerbated left ventricular hypertrophy and evidence of heart failure, while the female GPR37L1 KO/KO mice were protected from cardiac fibrosis.",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","6",null,"het x het","No","2014-01-20","Cryopreserved sperm"]
[4474,"SPC-rtTA","C.FVB/N-Tg(SFTPC-rtTA)5Jaw/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 5, Jeffrey A Whitsett","human SFTPC (SPC) (surfactant protein-C)","respiratory epithelial cells",{"$nulls":10},"The human SFTPC promoter is active in respiratory epithelial cells.","BALB/c x FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-02-22","Cryopreserved sperm"]
[8589,"F2rl1tm1c:K14-cre","B6.129-F2rl1<tm1c(EUCOMM)Wtsi> Krt14<tm1.1(cre)Wbm>/Apb",null,"Recessive","coagulation factor II (thrombin) receptor-like 1","F2rl1",null,"Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2","MGI:101910","coagulation factor II (thrombin) receptor-like 1; targeted mutation 1c, Wellcome Trust Sanger Institute","F2rl1<tm1c(EUCOMM)Wtsi>","MGI:6151132","13",{"$nulls":28},"These mice were subjected to a model of periodontitis involving placement of a ligature around a tooth, combined with P. gingivalis infection (\"Lig + Inf\"). The intervention caused a significant 44% decrease in alveolar bone volume (assessed by microcomputed tomography) in wildtype (K14-Cre:F2rl1wt/wt ), but not littermate keratinocyte-specific PAR2 -null (K14-Cre:F2rl1fl/fl ) mice. Keratinocyte-specific ablation of PAR2 prevented the significant Lig + Inf-induced increase (2.8-fold) in the number of osteoclasts in alveolar bone and the significant up-regulation (2.4-4-fold) of the inflammatory markers IL-6, IL-1β, interferon-γ, myeloperoxidase, and CD11b in gingival tissue.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-17","Cryopreserved sperm"]
[7575,"37L1null","B6;129S1/SvImJ-Gpr37l1<tm1>/Apb",null,"Dominant","G protein-coupled receptor 37-like 1","Gpr37l1","Nil","CAG-18, D0Kist8","MGI:1928503",{"$nulls":3},"1",{"$nulls":28},"Elevated blood pressure","Unknown. Potentially elevated blood pressure.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","unknown","unknown","hom x hom","No","2014-01-20","Cryopreserved sperm"]
[7576,"37L1cTg","C57BL/6-Tg(αMHC-Gpr37L1)/Apb",null,"Dominant",{"$nulls":25},"G protein-coupled receptor 37-like 1","alpha-myosin heavy chain",{"$nulls":10},"Unknown.","Unknown. ","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Pure background",null,"hom x hom","No","2014-01-20","Cryopreserved sperm"]
[6538,"JAK3?","B6;129S4-Jak3<tm1Ljb>/JAusb",null,"Recessive","Janus kinase 3","Jak3","Nil",null,"MGI:99928","Janus kinase 3; targeted mutation 1, Leslie J Berg","Jak3<tm1Ljb>","MGI:1857276","8",{"$nulls":28},"Decreased CD4-positive T cell number:*Decrease in the proportion and absolute number of CD4+ cells in the spleen.Decreased CD8-positive T cell number:*Decrease in the proportion and absolute number of CD8+ cells in the spleen.Abnormal dendritic cell morphology      Decreased myeloid dendritic cell number:      *The proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen.      *However, the frequency plasmacytoid dendritic cells in the spleen is not significantly different from wild-type controls.      Abnormal dendritic cell differentiation:      *Splenic dendritic cells express higher levels of activation markers compared to cells from wild-type controls.      *However, bone marrow precursors in vitro show a similar capacity to generate immature dendritic cells compared to wild-type controls.Abnormal splenic cell ratio:*Reduced numbers of splenocytes.*Decrease in the proportion and absolute number of CD11c+ dendritic, CD4+, and CD8+ cells in the spleen.*However, the frequency plasmacytoid dendritic cells is not significantly different from wild-type controls.Abnormal dendritic cell physiology:*In culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis.*Bone marrow-derived dendritic cells overproduce IL12 and IL10.*When bone marrow-derived dendritic cells are used in an adoptive transfer model the proportion of IFNG-producing cells is increased compared to when wild-type cells are used.","Abnormal leukocyte morphology:*Slight increase in the number of cells classified as myeloid or premonocytic.      Decreased lymphocyte cell number:      *Lymphopenia is seen in peripheral and bone marrow smears.      *At 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased.      Increased leukocyte cell number:      *At 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen.      *These large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage.         Increased neutrophil cell number:         *Significantly higher numbers of both segmented and band neutrophils.         Increased monocyte cell number:         *At 6 - 12 months of age in the bone marrow and spleen.","Mixed mice","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7577,"AKBbm1","STOCK H2-K<bm1> Tg(Alb-H2-K<b>)/Apb",null,"Dominant","histocompatibility 2, K region","H2-K","Unknown",null,"MGI:3040519","histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17",{"$nulls":16},"mouse H2-K<b> (MHC class I)","Mouse albumin promoter","similar to wild type H2-K<b> expression",{"$nulls":9},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"No","2014-01-21","Cryopreserved sperm"]
[8536,"C66 ; Hobit","C57BL/6JMarp-Zfp683<em1Mgmp>/MgmpApb",null,"Recessive","zinc finger protein 683","Zfp683","Unknown","Hobit","3650254 ",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2018-07-13","Cryopreserved sperm"]
[6859,"18YAA024a","ENU18Yaa:024a",null,"Recessive","accelerated autoimmunity and lymphoproliferation transposition","Yaa","Unknown","Tp(X;Y)1Ekw","MGI:99140",null,null,"MGI:1856277","Y",{"$nulls":15},"Yes",{"$nulls":12},"Low B cell numbers",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-03-20","Cryopreserved sperm"]
[4529,"B6.129-163C KI Tg1","B6.129-Ryr1<tm2Alle>/AnuApb",null,"Recessive","ryanodine receptor 1, skeletal muscle","Ryr1","Normal","calcium release channel isoform 1, Ryr, skrr","MGI:99659","ryanodine receptor 1, skeletal muscle; targeted mutation 2, Paul D Allen","Ryr1<tm2Alle>",null,"7",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic Lethal E17-18.","Fulminant malignant hyperthermia episodes inR163C heterozygous mice after exposure to 1.25–1.75% halothaneor an ambient temperature of 42°C characterized by increasedrectal temperature, respiratory rate, and inspiratoryeffort, with significant blood biochemical changes indicatingmetabolic acidosis, ending in death and hyperacute rigor mortis;(3) intraperitoneal pretreatment with dantrolene provided100% protection from the halothane-triggered fulminant malignanthyperthermia episode; (4) significantly increased sensitivity(decreased effective concentration causing 50% of the maximalresponse) of R163C heterozygous and homozygousmyotubes to caffeine, 4-chloro-m-cresol, and K\u0001-induced depolarization;(5) R163C heterozygous and homozygous myotubeshave a significantly increased resting intracellular Ca2\u0001 concentrationcompared with wild type; (6) R163C heterozygous sarcoplasmicreticulum membranes have a twofold higher affinity(Kd =35.4 nM) for [3H]ryanodine binding compared with wild type (Kd=\u0002 80.1 nM) and a diminished inhibitory regulation byMg2\u0001.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","4",null,null,"No","2009-02-27","Cryopreserved sperm"]
[8538,"ERT-Cre-SB-Neu","STOCK Tg(Elf5-rtTA/TetO-cre) Tg(MMTVneu) TgTn(sb-T2/Onc2)Njen/OnjcriApb",null,"Recessive",{"$nulls":25},"Elf5-rtTA/TetO-cre","E74-like factor 5",{"$nulls":10},"Normal","Normal","C57BL/6:Balb/c:FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-07-26","Cryopreserved sperm"]
[7771,"Ptcd3","C57BL/6NCrlAnu-Ptcd3<m1Anu>/AnuApb",null,"Recessive","pentatricopeptide repeat domain 3","Ptcd3","Unknown","2610034F17Rik, 2810422B04Rik ","MGI:1917206 ",{"$nulls":3},"6","ENSMUSG00000063884","ENSMUST00000082094","Ptcd3-201","289","311","A to T","ENSMUSE00000432359","5","97","Isoleucine to Lysine",{"$nulls":4},"CTTATGTATTTCACGATGATCCTTACCTCATACCAACCTCTGCTCTGGAGTCTCGTTCATT",{"$nulls":13},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","Het x Het","No","2014-10-13","Cryopreserved sperm"]
[8539,"ASD550:Juanfran:::F6","C57BL/6NCrlAnu-Samsn1<em1Anu>/AnuApb",null,"Recessive","SAM domain, SH3 domain and nuclear localization signals, 1","Samsn1","Unknown","4930571B16Rik, Hacs1","MGI:1914992",{"$nulls":3},"16",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-07-27","Cryopreserved sperm"]
[6871,"APN206","C57Bl/6NTac-Gpr183<tm1(KOMP)Vlcg>/MarpApb",null,"Recessive","G protein-coupled receptor 183","Gpr183","Unknown","Ebi2","MGI:2442034","G protein-coupled receptor 183; targeted mutation 1, Velocigene ","Gpr183<tm1(KOMP)Vlcg>","MGI:3808449","14",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-04-05","Cryopreserved sperm"]
[6830,"APN 128","C57Bl/6NPxmp4<tm1(KOMP)Wtsi>/MarpApb",null,"Recessive","peroxisomal membrane protein 4","Pxmp4 ","Unknown","3010018P03Rik ","MGI:1891701 ","peroxisomal membrane protein 4; targeted mutation 1, Wellcome Trust Sanger Institute ","Pxmp4<tm1(KOMP)Wtsi> ","MGI:4419659","2",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-03-01","Cryopreserved sperm"]
[5922,"Mycbp2-15mttMb",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8318,"CIB1 Knockout","B6.129S6-Cib1<tm1Prse>/Apb",null,"Recessive","calcium and integrin binding 1 (calmyrin)","Cib1","Nil","Kip","MGI:1344418","calcium and integrin binding 1 (calmyrin); targeted mutation 1, Leslie V Parise","Cib1<tm1Prse>","MGI:3690129","7",{"$nulls":28},"Female, normalDecreased testis weight:• weight of testis at 3-4 months of age is about 47.5% that of controlsAbnormal spermatogenesis:\t• spermatogonia, spematocytes, and round spermatids are present in the testis; however, seminiferous tubules lack advanced spermatids, have multinucleated spermatids near the tubule lumen and no sperm are found in the epididymis• increase in spermatid apoptosis in the testisAzoospermia:\t• sperm production is undetectable in the epididymisAbnormal spermiogenesis.• disruption of the haploid phase of germ cell differentiationarrest of spermatogenesis.• spermatogenic cells complete both mitotic and meiotic divisions, however postmeiotic spermatids do not develop normally and sperm are not producedMale infertility:\t• males are sterile due to disruption of the haploid phase of spermatogenesis","Both female and male are normal","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm"]
[5928,"Neogenin 129",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7075,"ENU24:006:5730590G19RIK","C57BL/6NCrlAnu-Ticrr<m1Anu>/AnuApb","C57BL/6NCrlAnu-Ticrr<m1Anu>/AnuApb","Recessive","TOPBP1-interacting checkpoint and replication regulator","Ticrr",null,"5730590G19Rik","MGI:1924261","TOPBP1-interacting checkpoint and replication regulator; mutation 1, The Australian National University","Ticrr<m1Anu>","MGI:5563404","7","ENSMUSG00000046591","ENSMUST00000035977","Ticrr-201","1748","1892","A to C","ENSMUSE00000592184","7","583","Asparagine to Threonine",{"$nulls":4},"TACCATGTCCCGCTCCTTGAAGATGTTGAATGTGGCAAGGCTAAATGTAAAGGCTCAGAAA",{"$nulls":13},"Homozygous mice are mostly hairless, with only a light patch of hair around the face and tail. ","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-09-05","Cryopreserved sperm"]
[5931,"NesCreERT2Line4 x IDTR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[110,"Arjuna ; ILK3","C57BL/6JSfdAnu-Tg(ILK3mHEL)3Ccg/AnuApb","C57BL/6JSfdAnu-Tg(ILK3mHEL)3Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":11},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"6","sib x sib","No","2006-02-06","Cryopreserved sperm"]
[7567,"Alpha 2 mice","B6.129-Gabra2<tm1.1Geh>/J",null,"Recessive","gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2","Gabra2","Nil","C630048P16Rik, Gabra-2","MGI:95614","gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2; targeted mutation 1.1, Gregg E Homanics","Gabra2<tm1.1Geh>","MGI:5000434","5",{"$nulls":28},"Homozygotes are under represented at birth.  They respond differently to alcohol and anaesthetics ","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-01-15"]
[5314,"BALB.Lyn up/up ","BALB/c-Lyn<tm1Mhi>/Apb",null,"Semi-dominant","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Reduced","Lyn<up>, Lyn<Y508F>","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Margaret Hibbs","Lyn<tm1Mhi>","MGI:2157016","4",{"$nulls":15},"Yes",{"$nulls":12},"The mice carry a gene-targeted gain-of-function mutation in the Lyn tyrosine kinase (Y508F).  The mice display a severe diminution of mature B cells but have increased numbers of B1a B cells.  Their B cells display marked down-regulation of surface IgM, Ig-beta, CD19, CD21 and CD22, and they are poorly responsive to B cell receptor cross-linking. Unlike mixed genetic background Lyn<up/up> mice, BALB/c background mice are not autoimmune-prone.  Due to the dominant nature of the gain-of-function Lyn mutation, Lyn-expressing cells from Lyn<up/up> mice show hyper-phosphorylation of many signaling proteins.On the BALB/c genetic background, the mice develop a severe inflammatory lung disease that resembles bullous emphysema.  The disease is obvious in 12 wk old mice.","Lyn<+/up> mice show a reduction in numbers of B cells and Lyn-expressing cells show hyper-phosphorylation of many signaling proteins.","Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2010-11-09","Cryopreserved sperm"]
[7019,null,"ENU22:Bcl2:022:b:B6",null,"Recessive",{"$nulls":37},"The strain has a possible low lymphocyte phenotype.",null,null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-07-12","Cryopreserved sperm"]
[7265,"B6.D2-CHR1","B6.D2-(D1Mit124-D1Mit291)",null,"Semi-dominant",{"$nulls":28},"Unknown",{"$nulls":7},"1","Anxious, low exploratary behaviour in open field, memory defict for contextaul fear memory","unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",">10",">2","standrad breeding to maintain homozygosity, sib-mating not required","Yes","2013-01-22"]
[6701,"Gt1","B6D2-T2(ACTA1-GTF2IRD1.1alfa1)22Hrd/Ausb",null,"Recessive",null,"Gt1",{"$nulls":35},"None",null,"B6D2","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[6546,"ID1GFP","B6.129X1-Id1<tm1Xhsu>/Ausb",null,"Dominant","inhibitor of DNA binding 1","Id1","Normal","bHLHb24, D2Wsu140e, Idb1 ","MGI:96396","inhibitor of DNA binding 1; targeted mutation 1, Xiao-Hong Sun","Id1<tm1Xhsu>","MGI:3831561","2",{"$nulls":28},"Decreased hematopoietic stem cell number:*There is a 45% reduction in the number of long-term HSC in whole bone marrow cells based on the ability to generate multilineage engraftment after serial transplantation in irradiated hosts.*Similar results are observed when fractions of bone marrow cells enriched in stem cells are used in serial transplantation of irradiated hosts.*Multilineage engraftment in the primary bone marrow transplant is the same when mutant or wild-type mice are the donors, indicating short term HSC cells are unaffected.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8597,"Grhl2+/-;Noggin+/-","B6(Cg).129-Grhl2<tm1.1Jane> Nog<tm1Amc>/Apb",null,"Recessive","grainyhead like transcription factor 2","Grhl2","Nil","061001","MGI:2182543","grainyhead like transcription factor 2; targeted mutation 1.1, Stephen M Jane","Grhl2<tm1.1Jane>","MGI:4836381","15",{"$nulls":28},"Embryos resulting from intercrosses, and which are genetically null for both Grhl2 and Noggin will be expected to have neural tube, skeletal and/or craniofacial defects.","Grhl2+/-;Noggin+/- adult mice appear to have no discernible phenotype","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-11-02","Cryopreserved sperm"]
[8546,"Foz:Jnk1 KO","C57BL/6-Alms1<foz> Mapk8<tm1Flv>/AnuApb",null,"Recessive","mitogen-activated protein kinase 8","Mapk8","Nil","c-Jun N-terminal kinase, JNK1, Prkm8 ","MGI:1346861","mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell","Mapk8<tm1Flv>","MGI:2176239","14"]
[107,"Albert ; KLK4","C57BL/6JSfdAnu-Tg(KLK4mHEL)6Ccg/AnuApb","C57BL/6JSfdAnu-Tg(KLK4mHEL)6Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 6, Christopher C Goodnow","H2-K<b>","Ubiquitous",{"$nulls":9},"Express membrane bound HEL under control of H2-K<b> promoter. Transmembrane domain cloned from H2-K<b> molecule.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"21","hom x hom","No","2006-02-06","Cryopreserved sperm"]
[161,"D3∆","B6.129P2-Dll3<tm1Rbe>/Apb","B6.129P2-Dll3<tm1Rbe>/Apb","Recessive","delta-like 3","Dll3","Nil",null,"MGI:1096877","Dll3 targetted mutation 1, Rosa Beddington","Dll3<tm1Rbe>","MGI:2178443","7",{"$nulls":15},"No",{"$nulls":12},"Homozygous mutants have shortened tail and trunk, with disorganised vertebrae and costal defects resulting from defective segmentation in the embryo and delayed and irregular somite formation.","None","C57BL/6","No","No","No","No","No","Yes","No","Good","10","11","+/Dll3<tm1Rbe> x C57BL/6. This was found to produce larger litters than +/Dll3<tm1Rbe> sib-matings","No","2006-03-09","Cryopreserved sperm"]
[7092,"Mekk2 ","ENU7PMH 130 B10:B6 (no ndfip1)",null,"Recessive","mitogen-activated protein kinase kinase kinase 2","Map3k2","Unknown","9630061B06Rik, Mekk2, MEK kinase 2","MGI:1346873",{"$nulls":3},"18",{"$nulls":28},"Unknown ","Unknown","C57BL/6SfdAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","unknown","unknown","het x het","No","2012-09-21","Cryopreserved sperm"]
[8548,"Foz:Tlr9 KO","C57BL/6-Alms1<foz> Tlr9<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 9","Tlr9","Nil",null,"MGI:1932389","toll-like receptor 9; targeted mutation 1, Shizuo Akira","Tlr9<tm1Aki>","MGI:2660562","9"]
[319,"B6.Prf -/-","C57BL/6-Prf1<tm1Sdz>/AnuApb","C57BL/6-Prf1<tm1Sdz>/Anu","Recessive","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfn, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":28},"Homozygous null mice exhibit increased susceptibility to viral infection and defective cytotoxic T cell cytolysis and NK cell cytolysis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","19",null,null,"No","2006-05-04","Cryopreserved sperm"]
[868,"C3H.OH","C3H.OH-H2<o2>/AnuApb","C3H.OH-H2<o2>/AnuApb","Dominant","histocompatibility-2, MHC","H2","Normal","H-2","MGI:95894",{"$nulls":3},"17",{"$nulls":15},"Yes",{"$nulls":14},"C3H/HeSf x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"brother x sister","No","2007-05-25","Cryopreserved sperm"]
[8547,"Foz:Ppara","C57BL/6-Alms1<foz> Ppara<em1Anu>/AnuApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Foz are hyperphagic leading to obesity. Males are sterile. High fat feeding accelerates obesity development, and leads to nonalcoholic steatohepatitis which progresses to liver fibrosis. Steatohepatitis also develops in chow-fed animals.Hyperglycemia: female mice are diabetic by 200 days of age.Increased circulating insulin level: female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type).Insulin resistance: female mice develop insulin resistance by 200 days of age.Increased eating behavior: mutants eat more than wild-type.Abnormal hepatocyte morphology: mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells.Enlarged liver: mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g).Increased liver weight: liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g).Liver fibrosis: mutant livers show pericellular and pericentral fibrosis.Hepatic steatosis: chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis.","Normal","C57BL/6","Yes","Unknown","Yes","Yes","No","Yes","Yes","Good",">10",null,"heterozygote mating","No","2018-08-06","Cryopreserved sperm"]
[8549,"MIC60","C57BL/6-Immt<tm1>/Apb",null,"Semi-dominant","inner membrane protein, mitochondrial","Immt",null,"1700082C19Rik, D830041H16Rik, HMP, mitofilin, P87, P87/89, P89","MGI:1923864",{"$nulls":3},"6",{"$nulls":28},"Normal","Normal","C57BL6J ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-08-07"]
[8601,"ENU44:G2","ANU:ENU44:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2018-11-07","Cryopreserved sperm"]
[5487,"A33:Lgp130YFKQ.B6 (Line 6). ","B6(Cg)-Tg(Gpa33-Il6*)6Ern/Lud",null,"Dominant",{"$nulls":25},"transgene insertion 6 Matthias Ernst","glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","12",null,null,"No","2011-04-19","Cryopreserved sperm"]
[8550,"ASD935:Navel:9","C57BL/6NCrlANu-Tlr3<em1Anu>/AnuApb",null,"Recessive","toll-like receptor 3","Tlr3","Unknown",null,"MGI:2156367",{"$nulls":3},"8",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-08-07","Cryopreserved sperm"]
[7578,"Inpp5efl","C57BL/6-Inpp5e<tm1Cmit>/Marp",null,"Dominant","inositol polyphosphate-5-phosphatase E","Inpp5e","Normal","1200002L24Rik, 72kDa, mKIAA0123","MGI:1927753",{"$nulls":3},"2",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-01-24","Cryopreserved sperm"]
[6725,"Tp3","F-Tg(ACTB-TPM3.Tm5NM1)52Pgun/Ausb",null,"Dominant",null,"Tp3",{"$nulls":35},"NoneHomozygous mice may have reduced lifespan due to convulsive fits. A high proportion of female mice have convulsive fits starting at 4-6 months of age. Males are less affected.",null,"FVBn","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[5933,"NestinCre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5308,"ENU17FOX:019 B6.129-Tg(FoxP3-GFP)","B6.129-Nup210<m1Anu> Foxp3<tm1Ayr>/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X"]
[5952,"NtrK-1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6580,"GPR43?","B6.Cg-Ffar2<tm1Dgen>/CrlAusb",null,"Dominant","free fatty acid receptor 2","Ffar2","Normal","Gpr43","MGI:2441731","free fatty acid receptor 2; targeted mutation 1, Deltagen","Ffar2<tm1Dgen>","MGI:4367910","7",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*In DSS-treated mice.Increased susceptibility to induced colitis:*During the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice.*Mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice.*TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice.*Transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice.Increased T cell number:*CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice.Abnormal granulocyte physiology:*Granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells.      Abnormal neutrophil physiology:      *Neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice.      *Neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells.      *Recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice.         Impaired neutrophil chemotaxis:         *Neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice.         Impaired neutrophil phagocytosis:         *Neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice.Increased susceptibility to induced arthritis:*While mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice.Lung inflammation:*Mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice.",null,"Mixed - mice","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[4877,"B6.B-cell deficient/Gal KO","C57BL/6-Igh-6<tm1Cgn> Ggta<tm1>/Apb",null,"Recessive","glycoprotein galactosyltransferase alpha 1, 3","Ggta1","Nil","alpha Gal, alpha3GalT, Gal, GALT, Ggta, Ggta-1, glycoprotein alpha galactosyl transferase 1","MGI:95704",{"$nulls":3},"2"]
[8553,"bhlhe40, C65","C57BL/6-Bhlhe40<em1Marp>/MarpApb",null,"Recessive","basic helix-loop-helix family, member e40","Bhlhe40","Unknown","Bhlhb2, C130042M06Rik, Clast5, CR8, cytokine response gene 8, DEC1, eip1 (E47 interaction protein 1), Sharp2, Stra13, Stra14","MGI:1097714","Conditional KO",null,null,"6",{"$nulls":28},"unknown","normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-08-30","Cryopreserved sperm"]
[6761,"ENU17FOX:008","C57BL/6JAnu-Il17f<m1Anu> Foxp3<tm2Ayr>/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X"]
[4113,"Helpless, ENU9B6:035","C57BL/6JAnu-Zbtb7b<hpls>/AnuApb","C57BL/6JAnu-Zbtb7b<hpls>/AnuApb","Recessive","zinc finger and BTB domain containing 7B","Zbtb7b","Unknown","c-Krox, Th-POK, Thpok, Zfp67","MGI:102755","zinc finger and BTB domain containing 7B; helpless","Zbtb7b<hpls>","MGI:3838356","3","ENSMUSG00000028042","ENSMUST00000029677","Zbtb7b-001","305","480","T to G","ENSMUSE00000175423","2","101","Leucine to Arginine",{"$nulls":4},"CTTTGTAGGGCCAGAGGCCCTAGGTGCCCTGCTCGAGTTTGCTTACACAGCCACACTGACC","No",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal primary T cell dependent antibody response. Very few CD4 T cells in peripheral blood or in thymus.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",">8",null,"Affected Male x C57BL/6JAnu","No","2008-12-05","Cryopreserved sperm"]
[7581,null,"B6/Mrit-135080","B6/Mrit-135080","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display an harmonious and transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-02-03","Cryopreserved sperm"]
[7606,"Joey-RSA","B6(Cg)-Rbm5<sda>/MarpApb",null,"Recessive","RNA binding motif protein 5","Rbm5","Unknown",null,"MGI:1933204","Joey",null,null,"9","ENSMUSG00000032580","ENSMUST00000035199","Rbm5-201","788","940","G to C","ENSMUSE00000251397","10","63","Arginine to Proline",{"$nulls":4},"CTATGCTTCCTTAGCTGTCAATAACATTCGCCTCATAAAAGACAAACAGACACAACAGAAC","Yes",{"$nulls":12},"Round spermatid arrest",null,"C57BL/6JMarp","Yes","Yes","Yes","Yes","No","Yes","No","Unknown","14",null,null,"No","2014-02-27"]
[1508,"FAS.AB","B6.Cg-Gzma<tm1Simn> Gzmb<tm1Ley> Fas<tm1Osa>/Apb","B6.Cg-Gzma<tm1Simn> Gzmb<tm1Ley> Fas<tm1Osa>/Apb","Dominant","granzyme B","Gzmb","Unknown","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14"]
[4980,"Vila ; ENU12NIH:028","C57BL/6JAnu-Btk<vila>/AnuApb","C57BL/6JAnu-Btk<vila>/AnuApb","Recessive","Bruton agammaglobulinemia tyrosine kinase","Btk","Unknown","Bruton's tyrosine kinase, X-linked immune deficiency, xid","MGI:88216","vila","Btk<vila>","MGI:4820731","X","ENSMUSG00000031264","ENSMUST00000113214","Btk-201","586","722","C to T","ENSMUSE00000277322","7","196","Glutamine to STOP",{"$nulls":4},"AGCCTCTTCCCCCTACCCCAGAGGAAGATCAGATCTTGAAAAAACCGCTTCCCCCGGAGCC","Unknown",{"$nulls":12},"Low peripheral blood B cell numbers. Decreased CD45 expression.Lower IgD expression.Higher IgG expression.Hyper IgE.","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[7370,"ENU25:011:Zmym2:B6:G5","C57BL/6NCrlAnu-Zmym2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Zmym2<m1Anu>/AnuApb","Recessive","zinc finger, MYM-type 2","Zmym2","Unknown","FIM, MGC:51607, MYM, RAMP, SCLL, Zfp198","MGI:1923257","zinc finger, MYM-type 2, mutation 1, The Australian National University","Zmym2<m1Anu>","MGI:5648435","14","ENSMUSG00000021945","ENSMUST00000022511","Zmym2-201","3774","3847","T to A","ENSMUSE00000122336","22","1258","Cysteine to STOP",{"$nulls":4},"AATCCTTTAACAATGGAAAATAAAGCATGTCTTCGCTATCAGGTGTCTTCCTTATGTGGAA",{"$nulls":13},"No homozygous animals born. Presume embryonic lethal","Normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"5",null,"No","2013-07-05","Cryopreserved sperm"]
[6848,"ENU24FoxRag G1","ENu24FoxRag:G1",null,"Dominant","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Foxp3 KO x Rag1 KO quickly develop lymphoproliferative disease.ENU induced mutation of unknown gene results in delayed onset of lymphoproliferative disease",null,"C57BL/6NCrl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","Poor","0","0",null,"No","2012-03-13","Cryopreserved sperm"]
[8607,"DMP1Cre.Socs3","B6-Socs3<tm2Wsa> Tg(Dmp1-cre)1Jqfe/StVApb",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Unknown","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":16},"transgene insertion 1, Jian Q Feng","Dmp1","odontoblast-specific expression",{"$nulls":9},"We have assessed the bone phenotype of the osteocyte-specific SOCS3 null mouse, and have found that they have significant sex-specific changes in bone mass.","Normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2018-11-20","Cryopreserved sperm"]
[4979,"Avon ; ENU11B6:178a","C57BL/6JAnu-Xrcc6<avon>/AnuApb","C57BL/6JAnu-Xrcc6<avon>/AnuApb","Recessive","X-ray repair complementing defective repair in Chinese hamster cells 6","Xrcc6",null,"G22p1, Ku p70, Ku70","MGI:95606","avon","Xrcc6<avon>","MGI:4458398","15","ENSMUSG00000022471","ENSMUST00000069530","Xrcc6-201","1400","1494","T to C","ENSMUSE00000127289","10","467","Leucine to Proline",{"$nulls":4},"AGACAAGATGAAGGCCATTGTTCAAAAGCTCCGCTTCACATACAGGAGCGACAGTTTTGAG","Yes",{"$nulls":12},"Very low B and T cell numbers in peripheral blood and spleen.Phenotype similar to Rag1 KO.","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[7662,"ENU23 32 (PPM1E) Asb3","C57BL/6NCrlAnu-Asb3<m1Anu>/AnuApb","C57BL/6NCrlAnu-Asb3<m1Anu>/AnuApb","Recessive","ankyrin repeat and SOCS box-containing 3","Asb3","Unknown","2400011J03Rik","MGI:1929749","ankyrin repeat and SOCS box-containing 3; mutation 1, The Australian National University","Asb3<m1Anu>","MGI:5563516","11","ENSMUSG00000020305","ENSMUST00000020551","Asb3-001","632","820","G to A","ENSMUSE00001205336","6","211","Aspartic acid to Asparagine",{"$nulls":4},"TGGTGCAAATGTCAATTGCCAAGCCTTGGATAAAGCTACTCCTTTGTTTATTGCTGCACAA",{"$nulls":13},"Reduced CD44 protein expression on B cells.","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-04-11","Cryopreserved sperm"]
[1541,"Kapil Dev","C57BL/6-Gzma<tm1Simn> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",null,"High - 49 Copies",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[8610,"ENU43:054:Lck","C57BL/6NCrlAnu-Lck<m1Anu>/Anu",null,"Recessive","ymphocyte protein tyrosine kinase","Lck","Unknown","Hck-3, p56<lck>","MGI:96756",{"$nulls":3},"4",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-11-21"]
[5483,null,"C57BL/6-Tg(UBC-GFP)30Scha/JAdelApb",null,"Recessive",{"$nulls":25},"transgene insertion 30, Brian Schaefer","Human ubiquitin C","Higher than normal",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"Homozygous x homozygous","No","2011-04-15","Cryopreserved sperm"]
[8611,"ENU43:139:Pax5","C57BL/6NCrlAnu-Pax5<m4Anu>/AnuApb","C57BL/6NCrlAnu-Pax5<m4Anu>/AnuApb","Recessive","paired box gene 5","Pax5","Unknown","EBB-1, Pax-5","MGI:97489","paired box gene 5; mutation 4, The Australian National University","Pax5<m4Anu>",null,"4",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":14},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2018-11-21","Cryopreserved sperm"]
[8612,"ENU41:076:Gsdmd","C57BL/6NCrlAnu-Gsdmd<m2Anu>/AnuApb",null,"Recessive","gasdermin D","Gsdmd","Unknown","1810036L03Rik, DF5L, Dfna5l, Gsdmdc1, M2-4","MGI:1916396",{"$nulls":3},"15",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"1",null,"No","2018-11-21","Cryopreserved sperm"]
[7660,"ENU27:039:PRC1","C57BL/6NCrlAnu-Prc1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Prc1<m1Anu>/AnuApb","Recessive","protein regulator of cytokinesis 1","Prc1",null,"D7Ertd348e, MGC:6745","MGI:1858961","protein regulator of cytokinesis 1; mutation 1, The Australian National University","Prc1<m1Anu>","MGI:5563437","7","ENSMUSG00000038943","ENSMUST00000163812","Prc1-002",{"$nulls":7},"80307696","8",null,null,"GAGAGCTGGAAACTTTTCCTAGAGTTTGAGGTAATATCCCTGTTTTAGCTGTGTTGCTCT",{"$nulls":13},"Embryonic lethal","normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2014-04-11","Cryopreserved sperm"]
[5124,"B6-ANU.A2G-Mx1/IFNAR-/-Mx1+/+","B6.A2G-Mx1<r> Ifnar1<tm1Agt>/AnuApb",null,"Dominant","interferon (alpha and beta) receptor 1","Ifnar1","Nil","Ifar, IFN-alpha/betaR, Ifrc","MGI:107658","interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet","Ifnar1<tm1Agt>","MGI:1930950","16",{"$nulls":15},"No",{"$nulls":12},"Due to the lack of a functional type I interferon receptor (IFNAR), mice don't respond to interferon (IFN) alpha/beta. Consequently they are highly susesptible to virus infections.","Normal in respect to IFN signalling, but highly resistant to influenza virus infections due to Mx1 (note that most inbred strains such as B6 and Balb don't have functional Mx genes). ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","More than 10",null,null,"No","2010-05-19","Cryopreserved sperm"]
[7588,"Recql4 LacZ","C57BL/6N-Recql4<tm3(EUCOMM)Wtsi>/MarpStvApb",null,"Dominant","RecQ protein-like 4","Recql4",null,"RECQ4","MGI:1931028","RecQ protein-like 4; targeted mutation 3, Wellcome Trust Sanger Institute","Recql4<tm3(EUCOMM)Wtsi>","MGI:5050948","15",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Good","generated on a C57bl6 background",null,"ki/+ to ki/+","No","2014-02-14","Cryopreserved sperm"]
[7591,"R26-CreER Recql4fl/fl pRbfl/fl","C57BL/6-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Recql4<tm2272Arte> Trp53<tm1Brn>/StvApb",null,"Dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","transformation related protein 53; targeted mutation 1, Anton Berns","Trp53<tm1Brn>","MGI:1931011","11",{"$nulls":28},"Normal in absence of tamoxifen treatment.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","generated on a C57bl6 background",null,"R26-CreERki/+ homozygous Recql4 and p53 intercrosses","No","2014-02-14","Cryopreserved sperm"]
[7590,"R26-CreER p53fl/fl pRbfl/fl","C57BL/6-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Rb1<tm3Tyj> Trp53<tm1Brn>/StvApb",null,"Dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","transformation related protein 53; targeted mutation 1, Anton Berns","Trp53<tm1Brn>","MGI:1931011","11",{"$nulls":28},"Normal in absence of tamoxifnen treatment.","no phenotype","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","generated on a C57bl6 background",null,"R26-CreERki/+ homozygous pRb and p53 intercrosses","No","2014-02-14","Cryopreserved sperm"]
[7590,"R26-CreER p53fl/fl pRbfl/fl","C57BL/6-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Rb1<tm3Tyj> Trp53<tm1Brn>/StvApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor ","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks","Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>","MGI:3699244","6"]
[6190,"APOE","B6.129P2-Apoe<tm1Unc>/JWehi",null,"Recessive","apolipoprotein E","Apoe","Nil",null,"MGI:88057","apolipoprotein E; targeted mutation 1, University of North Carolina","Apoe<tm1Unc>","MGI:1857129","7",{"$nulls":28},{"$cut":{"chars":19959,"head":"premature death (J:73202)35% dead by 18 monthscardiovascular systemabnormal aorta wall morphology (J:101576, J:142083)endothelial nitric oxide synthase (eNOS) in mutant aortic wall is distinctly reduced (J:101576)Cx43 distribution at cell-cell junction shows significant disruption (J:142083)abnormal spiral modiolar artery morphology (J:101576)homozygotes fed an atherosclerotic diet develop atherosclerotic alterations in the spiral modiolar artery (SMA)in contrast, no such changes are detected in the SMA of homozygotes fed a normal dietarteriosclerosis (J:108154)homozygotes exhibit a 13% increase in aortic pulse-wave velocity (PWV) relative to wild-type mice (428 ? 14.5 cm/s vs 379 ? 10.1 cm/s), indicating increased arterial stiffness and reduced vascular elasticityatherosclerotic lesions (J:133606, J:73202, J:108154, J:97385, J:101576, J:60364, J:105736, J:142083)advanced atherosclerotic lesions; massive atheromas with abundant cholesterol crystals, neutral lipids, and diminished extracellular matrix in arotic roots and coronary arteries (J:73202)at 13 months, homozygotes display atherosclerotic lesions extending from the carotid arteries, heart, and aorta down to the renal arteries and the iliac bifurcation (J:108154)lesions are most severe in the proximal aorta and at the bifurcation of carotid arteries; the proximal carotid arteries are relatively free of lesions (J:108154)regular exercise does not reduce atherosclerotic lesion formation in homozygotes, as shown by a comparable % oil red-O staining of whole aortas from sedentary and exercised mutant mice (J:97385)at 24 weeks of age, homozygotes fed a normal diet (but not similarly-fed C57BL/6J control mice) show obvious atherosclerotic lesions in the aortic sinus and ascending aorta (J:101576)the number of atherosclerotic lesions in aortic sinus and ascending aorta is significantly increased in homozygotes fed an atherosclerotic diet vs a normal diet (J:101576)plaques in the luminal surface of the aorta are significantly larger in atherosclerotic diet homozygotes than in normal diet homozygotes (J:101576)23% of luminal surface in the aortic arch and thoracic aorta is covered by plaques at 4 months of age (J:60364)61% covered by plaques at 13 months of age (J:60364)thickened intima, foam cell accumulation and thin collagen cap (J:60364)focal fragmentation of elastic laminae (J:60364)intimal lesions are observed in atherosclerotic aortas in mutants (J:105736)major lesions are observed on lesser curvature of aortic arch in males and females with minor lesions found at branches of aortic arch (J:142083)lesions comprise around 14-16% of total aortic arch area in male and female mutants (J:142083)aortic lesions are observed in aortic sinus at level of aortic valve leaflets; lesions are about 27% of total aortal area (J:142083)increased susceptibility to atherosclerosis (J:101576, J:43846)severity of atherosclerosis is 2-fold and 99-fold higher in atherosclerotic diet homozygotes than in normal diet homozygotes and C57BL/6J control mice, respectively (J:101576)on a high fat, high cholesterol diet, mutants exhibit moderate to severe aortic and carotid atherosclerosis (J:43846)vascular stenosis (J:101576)vascular stenosis is significantly increased in homozygotes fed an atherosclerotic diet vs a normal dietspiral modiolar artery stenosis (J:101576)lumen stenosis of the spiral modiolar artery in the cochlea is exacerbated by an atherosclerotic diet relative to a normal dietincreased heart weight (J:108154)at 13 months, homozygotes show a 23% increase in heart weight relative to wild-type mice (186 ? 7.1 vs. 151 ? 2.5 mg)cardiac hypertrophy (J:108154)at 13 months, homozygotes show a 59% increase in heart weight-to-body weight ratio relative to wild-type miceabnormal blood flow velocity (J:108154)anesthetized homozygotes show significantly increased transaortic blood velocities relative to wild-type mice with peak aortic velocity at 133.4 ? 7.8 cm/s vs 89.2 ? 5.8 cm/s, and mean aortic velocity at 35.9 ? 2.7 vs 22.0 ? 1.6 cm/s, respectivelyin addition, anesthetized homozygotes sho"}},null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6188,"472/Del","B6.129S1-Bcl2l11<tm1Ast>",null,"Recessive","BCL2-like 11 (apoptosis facilitator) ","Bcl2l11","Nil","1500006F24Rik, Bim, Bod ","MGI:1197519 ","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser ","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":28},"Abnormal hippocampus morphology:*2 days after neonatal hypoxia-ischemia (HI) injury, ispsilateral hippocampal area loss (7.8%) is half of that seen in wild-type mice (16.8%) after HI.Gliosis:*Reactive gliosis is significantly decreased in hippocampi of mutants 2 days after neonatal HI compared to wild-type.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6199,"MLL-Af9","B6.129P2(Cg)-Mll1<tm2(MLLT3)Thr>/KsyJ",null,"Dominant","myeloid/lymphoid or mixed-lineage leukemia 1","Mll1",null,"ALL-1, All1, Cxxc7, HTRX1, KMT2A, Mll, trithorax Drosophila ","MGI:96995","myeloid/lymphoid or mixed-lineage leukemia 1; targeted mutation 2, Terrence H Rabbitts","Mll1<tm2(MLLT3)Thr>","MGI:2671905","9",{"$nulls":28},"Prenatal lethality","Leukemia:*Predominantly acute myeloid leukemia (AML) involving immature myeloblasts and extramedullary leukemia.*A minority of the observed leukemia is acute lymphoblastic leukemia (ALL).*50% of heterozygotes succumb to AML at 5 months of age.*Almost all mice develop malignancy within 1 1/2 years.Abnormal hematopoiesis:*Abnormal hematopoietic differentiation resulting in an accumulation of Mac-1/Gr-1 double-positive mature myeloid cells in the bone marrow preceded the onset of AML, as early as 6 days of age.Enlarged spleenEnlarged liverPale kidney","C57BL/6 x 129","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6868,"SM02-Dist","SuprMam02-(B6.BALB/c-SM1)-Dist/AnuApb",null,"Recessive",{"$nulls":28},"SuprMam","SuprMam",{"$nulls":3},"SuprMam-BALB/c","SuprMam-BALB",null,"7","Mice are more susceptible to mammary tumours.","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","11",null,null,"No","2012-04-03","Cryopreserved sperm"]
[6207,"B6/Moz3/Bmi","B6;129-Bmi1<tm1Brn> Myst3<tm1Avo>",null,"Recessive","MYST histone acetyltransferase (monocytic leukemia) 3","Myst3","Nil","9930021N24Rik, KAT6A, MOZ, Zfp220","MGI:2442415","MYST histone acetyltransferase (monocytic leukemia) 3; targeted mutation 1, Anne K Voss","Myst3<tm1Avo>","MGI:3626344","8"]
[6216,"B6CIS","C57BL/6-Socs2<tm1Wehi>",null,"Recessive","suppressor of cytokine signaling 2","Socs2","Nil","CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2","MGI:1201787","suppressor of cytokine signaling 2; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs2<tm1Wehi>","MGI:1934557","10",{"$nulls":28},"Increased body length:*Male homozygotes display significantly a increased body length relative to wild-type males, although tail length is normal.*A similar but less pronounced trend is noted in the body length of female homozygotes.Increased body weight:*At 6 weeks of age, male homozygotes weigh significantly more than wild-type males; as adults, mutant males are, on average, 40% heavier than wild-type males.*Increased growth is also significant but less pronounced in females, though adult female homozygotes typically attain the weight of wild-type males.*Increased body weight results from the proportionate enlargement of most visceral organs and is not attributed to accumulated fatty tissue.*Sexually dimorphic or male-specific organs are not disproportionately enlarged.*Carcass weight is also increased, indicating that muscle and bone may contribute to increased size.Increased growth rate:*Homozygotes display accelerated growth after weaning i.e. beginning at around 3-4 weeks of age.Long radius:*The mutant tibia is significantly longer than in wild-type controls.Increased length of long bones:*Male homozygotes display significantly increased long bone lengths relative to wild-type males.*A similar but less pronounced trend is noted in the long bone lengths of female homozygotes.*However, bone architecture, including the epiphiseal growth plates of the femur and tibia, is histologically normal.      Long humerus      Long femur      Long tibiaAbnormal lung morphology:*At 2 months of age, 6 of 9 male, but only 3 of 10 female homozygotes show increased collagen deposition around the bronchi and vessels of the lungs; some alveolar sacs are occasionally involved.Abnormal hepatobiliary system morphology:*At 2 months of age, a minority of both male and female homozygotes display excess collagen accumulation around occasional hepatic vessels and bile ducts.Abnormal pancreatic duct morphology:*At 2 months of age, a minority of both male and female homozygotes display excess collagen accumulation in duct tissue of the pancreas.Abnormal salivary gland duct morphology:*At 2 months of age, a minority of both male and female homozygotes display excess collagen accumulation in duct tissue of the salivary glands.Abnormal insulin-like growth factor I level:*RNase protection assays indicate increased IGF-I production in several organs (heart, lungs and spleen), but not in liver, bone, fat or muscle.*However, no increase in serum IGF-I concentration is observed, consistent with normal production in the liver (major source of circulating IGF-I).Abnormal urine homeostasis:*At 6-7 weeks of age, all male and female homozygotes studied show decreased levels of major urinary protein (MUP) in their urine.Adipose tissue phenotype:*Neither male nor female mutants accumulate significantly more abdominal fatty tissue than wild-type mice.Thick dermal layer:*Adult homozygotes display a significantly thickened dermis, although most organs (including kidney, heart, spleen, thymus, lymph nodes, femur, sternum, gonads and bladder) appear histologically normal*Dermal thickening is associated with excessive collagen accumulation in all of male (7/7), and less prominently in female (6/8) homozygotes.","Increased body weight:*At 12 weeks of age, adult male heterozygotes show an intermediate body weight relative to wild-type and homozygous mutant littermates.*In contrast, female heterozygotes are not significantly heavier than wild-type females.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6213,"B6/G-CSF3R","B6.129X1-Csf3r<tm1Link>/Wehi",null,"Recessive","colony stimulating factor 3 receptor (granulocyte)","Csf3r",null,"Cd114, Csfgr, G-CSFR","MGI:1339755","colony stimulating factor 3 receptor (granulocyte); targeted mutation 1, Daniel C Link","Csf3r<tm1Link>","MGI:2156982","4",{"$nulls":28},"Normal development. Neutropenic. Mild immuno-compromised Keep hooded.Impaired neutrophil chemotaxis: no mobilization in response to granulocyte-colony stimulating factor (G-CSF)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6209,"B6.Rel-10","B6.129S1-Rel<tm1Grd>/Wehi",null,"Semi-dominant","reticuloendotheliosis oncogene","Rel","Normal","c-Rel","MGI:97897","reticuloendotheliosis oncogene; targeted mutation 1, Steve Gerondakis","Rel<tm1Grd>","MGI:2179622","11",{"$nulls":28},"Decreased B cell proliferation: * in culture, splenic B cells respond less efficiently to mitogenic stimulation; proliferative response is 0.5-2.5% of normal * B cell colonies are 100-fold less numerous compared with wild-type cells when splenocytes are seed onto agar cultures containing LPS * treatment of stimulated B cells with Il2 does not reverse proliferative defect in B cells.Decreased T cell proliferation: * in response to PMA stimulation, cultured T cells show only ~20% of normal response at 72 hours but in response to ionomycin, response is ~70% of normal * concanavalin A- or anti-CD3/anti-DC28-stimulated T cells cultured with exogenous Il2 show similar proliferative response to stimulated wild-type cells.Abnormal macrophage physiology: * resident peritoneal macrophages activated with LPS + interferon gamma show impaired cytotoxic killing ability towards tumor cells in vitro compared to wild-type macrophages * elicited macrophages from both genotypes show equal cytotoxic abilities * resident macrophages produce only ~20% of normal nitric oxide levelsAbnormal humoral immune response: * in response to a T cell-independent antigen (NP-LPS), IgG3 production is marginally reduced at 7 days after immunization, continuing to decrease over the next 14 days * NP-specific IgG1 production production is 50- to 100-fold lower than in wild-type in response to a T cell-dependent antigen (NP-KHL)Decreased IgG1 level: * levels are 100-fold less than in wild-type naive mice * IgG1 production production is 50- to 100-fold lower than in wild-type in response to a T cell-dependent antigen (NP-KHL)Decreased IgG2a level: levels are almost undetectable in naive mutants.Decreased IgG2b level: levels are 6-fold less than in wild-type naive mice.Decreased IgG3 level: levels are 4-fold less than in wild-type naive mice.Decreased IgM level: levels are 3-fold less than in wild-type naive mice.Abnormal cytokine secretion: * concanavalin A-stimulated T cells produce Il2 at levels that are 50-fold lower than wild-type; levels are several fold lower than normal in wild-type cultures stimulated with PMA or ionomycin. * with LPS treatment, GM-CSF and G-CSF production by resident macrophages is ~10- and 5-fold greater in wild-type macrophages. * levels of Il6 produced by unstimulated resident and peritoneal macrophages are elevated ~3-fold compared to wild-type; levels of Il6 after LPS stimulation are 3-5-fold higher than stimulated wild-type macrophages.Decreased susceptibility to parasitic infection.","Decreased B cell proliferation: * in culture, splenic B cells respond less efficiently to mitogenic stimulation; proliferative response is 14-20% of normal * B cell colonies are 10-fold less numerous compared with wild-type cells when splenocytes are seed onto agar cultures containing LPSAbnormal humoral immune response: NP-specific IgG1 production in response to a T cell-dependent antigen (NP-KHL) is intermediate between wild-type and homozygous mice; IgG3 response to NP-LPS is normal.","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6220,"B6del478/NFKB2","B6del478/NFKB2",{"$nulls":3},"  FasL      NFKB2   ",{"$nulls":35},"B6del478 - KI/KI develop enlarged lymphnodes and spleen. Not tumour at this stage. Mice at 10-12 months of age may develop lukaemia. T cell large granulocytic lukaemia.  May have autoimmune disease.  B6del478/NFKB2 - unknown.",null,"C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6228,"Bad","B6.129X1-Bad<tm1Sjk>",null,"Recessive","BCL2-associated agonist of cell death","Bad","Nil","Bbc2","MGI:1096330","BCL2-associated agonist of cell death; targeted mutation 1, Stanley J Korsmeyer","Bad<tm1Sjk>","MGI:2675966","19",{"$nulls":28},"Abnormal hippocampus morphology:*2 days after neonatal hypoxia-ischemia (HI) injury, ispsilateral hippocampal area loss (10.3%) is half of that seen in wild-type mice (21%) after HI.Gliosis:*Reactive gliosis is significantly decreased in hippocampi of mutants 2 days after neonatal HI compared to wild-type.",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6869,null,"Porthos:kk",null,"Dominant",{"$nulls":25},"Genomic IgG anti-HEL H + L",null,"low copy","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant ","H2<k>","MGI:3579322","17",null,null,"C57BL/6 x B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-04","Cryopreserved sperm"]
[6232,"CD1.1","BALB/c-Cd1d1/Cd1d2<tm1.2Aben>",null,"Recessive","CD1d1 antigen","Cd1d1","Nil","CD1.1, Cd1a, Cd1d, Ly-38","MGI:107674","CD1d1 antigen; targeted mutation 2.1, Albert Bendelac","Cd1d1/Cd1d2<tm1.2Aben>","MGI:5085993","3",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6235,"Bax/Bmf/472 ","B6.129-Bax<tm1Sjk> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser ","Bcl2l11<tm1Ast>","MGI:2156494","2"]
[6238,"Bcl-x/flox/Mcl-1flox/E�Myc","B6-Bcl2l1<Plt16> Mcl1<tm3Sjk> Tg(IghMyc)22Bri",null,"Semi-dominant","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; platelet 16","Bcl2l1<Plt16>","MGI:3847886","2",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Myc promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6246,"SCID/Arc","CB17-Prkdc<scid>",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":28},"Premature death:*Lifespan is shortened in conventional housing, however, in an SPF environment homozygotes can live to more than one year.Immune system phenotype:*In contrast to homozygotes on the NOD background, spleen cell suspensions from homozygous CB17 mice exhibit NK cell activity.      Salivary gland inflammation:      *In mice injected i.p. with cells from submandibular gland tissue of diseased Fas<lpr> mice, inflammatory lesions are observed in salivary and lacrimal glands.      *Infiltrating cells are CD4<+> and Vbeta8<+> with a minority being CD4<+> and Vbeta6<+>.      *Mice injected with cells pretreated with anti-CD4 or anti-Vbeta8 do not develop inflammatory lesions or only minor lesions are seen in parotid, submandibular, sublingual and lacrimal glands in majority of transplanted mice.      Decreased leukocyte cell number:      *Homozygotes are leukopenic.         Absent B cells:         *B cells cannot be detected in the spleen with Ig or Lyb-8 (Cd22) markers.            Absent pre-B cells:            *Pre-B cells cannot be detected in the bone marrow.      Decreased B cell proliferation:      *Spleen cells do not proliferate in response to LPS.      Decreased T cell proliferation:      *Splenic T cells do not proliferate in response to concanavalin A or to a one-way mixed lymphocyte reaction.      Abnormal spleen white pulp morphology:      *Splenic follicles are devoid of lymphocytic cells.      Abnormal thymus morphology:      *The remaining thymocytes that express the Thy1 marker are larger than normal thymocytes.         Abnormal thymus cortex morphology:         *Lymphocytic cortex is not evident in thymus.         *Mucinous cysts are occasionally found.         Small thymus:         *1/10th to 1/100th normal size.      Absent Peyer's patches:      *Peyer?s patches are rarely visible.      Lymph node hypoplasia:      *Lymph nodes have only a few lymphoid cells, however, sinuses are well-formed and contain macrophages.      Small lymphoid organs         Lymphoid hypoplasia:         *Lymphid organs are 1/10th or less of normal size.         *Lymph organs consist mostly of supportive tissue with varying numbers of fibroblasts, macrophages and histiocytes.      Abnormal humoral immune response:      *Mice are unable to produce specific antibody to two T-independent antigens.         Decreased immunoglobulin level:         *31/206 mice tested have low levels of serum immunoglobulin, all 31 have an IgG isotype and of these, 17 also have an IgM isotype.         *The remaining 175/206 mice do not have detectable serum immunoglobulin.         *Only 1/11 homozygotescan produce greater than 1 ug/ml serum Ig at up to 100 days of age, however, 21/29 homozygotes produce greater than 1 ug/ml between 100-200 days of age.            Decreased IgG level:            *Hypogammaglobulinemic.      Abnormal response to transplant:      *Following injection of human T lymphoblastoid cells, 40% of nucleated spleen cells are of human origin by 4 weeks post injection.         Increased length of allograft survival:         *Homozygotes do not reject full thickness skin allografts.         *1/5 homozygotes (5-6 weeks of age) reject orthotopic tail skin allografts throughout a 3 month observation period.Hematopoietic system phenotype:*In contrast to homozygotes on the NOD background, homozygous CB17 mice exhibit normal erythrocyte mean cell volumes.T cell derived lymphoma:*Spontaneous T cell lymphomas are found in greater than 10% of homozygotes at 5-9 months of age.*Tumors arise in the thymus and are highly invasive and are transplantable.Thymic lymphoma",null,"CB17","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6244,"Bmf/473/Bax","B6.129-Bax<tm1Sjk> Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 2.1, Philippe Bouillet","Bcl2l11<tm2.1Boui>","MGI:4366751","2"]
[6248,"B6/IRF4-enu/Blimp","C57BL/6-Irf4<m1Btlr> Prdm1<tm1Nutt>",null,"Recessive","interferon regulatory factor 4","Irf4","Normal","IRF-4, Spip","MGI:1096873","interferon regulatory factor 4; mutation 1, Bruce Beutler","Irf4<m1Btlr>","MGI:4456226","13",{"$nulls":30},"B6 x BALB mixed","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6254,"tcasp-8","B6.129P2-Casp8<tm1Raz> Tg<Lck-cre>548Jxm",null,"Semi-dominant","caspase 8","Casp8","Normal","Caspase-8, FLICE, MACH, Mch5","MGI:1261423","caspase 8; targeted mutation 1, Razqallah Hakem","Casp8<tm1Raz>","MGI:2655730","1",{"$nulls":16},"transgene insertion 548, Jamey Marth","mouse lck promoter",{"$nulls":10},"Premature death:*Die at an average age of 51.7 weeks, however lethality is sometimes seen as early as 14 weeks of age.Decreased body size      Decreased body weightDecreased leukocyte cell number:*Peripheral T cell lymphopenia is seen early in life but is no longer apparent in older mutants.      Decreased T cell number:      *Relative proportion of splenic and lymph node T cells is significantly lower in young mutants.         Decreased CD4-positive T cell number:         *Lower numbers of CD4+ T cells in young mutants.         Decreased CD8-positive T cell number:         *Lower numbers of CD8+ T cells in young mutants.Abnormal lymphocyte morphology:*Peripheral lymphocyte populations from spleens and lymph nodes of old mutants show a decreased B-to-T cell ratio.      Increased lymphocyte cell number:      *Lymphoproliferation in older mutants is confirmed by increased total lymphocyte counts.         Increased B cell number:         *Older mutants exhibit a balanced expansion of both B and T lymphocyte numbers in the periphery.         Increased T cell number:         *Older mutants exhibit a balanced expansion of both B and T lymphocyte numbers in the periphery.      Abnormal T cell morphology         Abnormal T cell subpopulation ratio:         *The CD4+ to CD8+ T-cell ratio is increased in spleen, lymph node, and peripheral blood.         *Peripheral lymphocyte populations from spleens and lymph nodes of old mutants show a decreased proportion of CD8+ T cells relative to CD4+ T cells         Abnormal T cell activation:         *Isolated T cells from old mutants are in a perpetual state of activation.            Abnormal T cell proliferation:            *T cells derived from older mutants exhibit defective in vitro proliferative responses to various stimuli and activated T cells are resistant to CD95L-induced apoptosis.               Decreased T cell proliferation:               *Exhibit defective activation-induced expansion of peripheral T cells.Enlarged spleenAbnormal lymph node morphology:*Lymphoid hyperplasia is apparent in older mutants.      Enlarged lymph nodes:      *In older mutants.      Abnormal CD8-positive T cell physiology:      *Do not exhibit an expansion of CD8+ T cells in the peripheral blood 6 days after lymphocytic choriomeningitis virus (LCMV) infection and show decreased representation of CD62L<high>CD44<low> (memory) T cells.      *LCMV-infected mutants are unable to generate CD8+ cytotoxic T cells specific for LCMV.      Decreased T cell apoptosis:      *Thymocytes and activated T cells are resistant to CD95L-induced apoptosis, however mitochondria-mediated apoptosis is normal.Abnormal liver morphology:*Livers from 30-week old mutants display T cell accumulation as focal perivascular infiltrates.Abnormal kidney morphology:*Kidneys from 30-week old mutants show focal interstitial and periglomerular T cell infiltration.Abnormal lung morphology:*Lungs from 30-week old mutants contain obvious interstitial peribronchiovascular T cell infiltration.*At about 1 year of age, disrupted lung tissue organization is associated with much more widespread and abundant T cell infiltration.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6252,"PLT4/GFP","C57BL/6-Mpl<tm1Wsa> Myb<Plt4> Tg(UBC-GFP)30Scha/JWehi",null,"Semi-dominant","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, thrombopoietin receptor, TPO-R","MGI:97076","myeloproliferative leukemia virus oncogene; targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":16},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6252,"PLT4/GFP","C57BL/6-Mpl<tm1Wsa> Myb<Plt4> Tg(UBC-GFP)30Scha/JWehi",null,"Semi-dominant","myeloblastosis oncogene","Myb","Normal","c-myb","MGI:97249","myeloblastosis oncogene; Plt4 ","Myb<Plt4>","MGI:3045843","10"]
[6262,"539/del","DEF2 4A8 ",{"$nulls":3},"   Bim    ",{"$nulls":35},"Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6265,"del376/266","B6.129S-Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod ","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":30},"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6267,"Puma/p21/Noxa","B6.129S-Bbc3<tm1Ast> Cdkn1a<tm1Tyj> Pmaip1<tm1Ast>",null,"Recessive","cyclin-dependent kinase inhibitor 1A (P21)","Cdkn1a","Nil","CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21<WAF1/CIP1>, p21Cip1, p21WAF, SDI1, Waf1","MGI:104556","cyclin-dependent kinase inhibitor 1A (P21); targeted mutation 1, Tyler Jacks","Cdkn1a<tm1Tyj>","MGI:1933751","17"]
[6267,"Puma/p21/Noxa","B6.129S-Bbc3<tm1Ast> Cdkn1a<tm1Tyj> Pmaip1<tm1Ast>",null,"Recessive","phorbol-12-myristate-13-acetate-induced protein 1","Pmaip1","Nil","Noxa","MGI:1930146","phorbol-12-myristate-13-acetate-induced protein 1; targeted mutation 1, Andreas Strasser ","Pmaip1<tm1Ast>","MGI:2681649","18"]
[6276,"E�Myc/delmnt/KO50","B6.129-Mnt<tm1.1Awb> Trp53<tm1Tyj> Tg(IghMyc)22Bri",null,"Semi-dominant","transformation related protein 53 ","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11"]
[6277,"Myc/Puma/Bim","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(IghMyc)22Bri",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Myc promoter",{"$nulls":12},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6280,"Fox03/myc10","Fox03/vav-myc10 x vav-myc10",{"$nulls":3},"  Fox03     myc10   ",{"$nulls":35},"Late onset (~10 months) thymoma or histiocytic sarcoma (subcutaneous tumour or enlarged liver or spleen). Might see acceleration with Fox03 -/- (not sure how many, if any).",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6282,"FVB/Bim","FVB-Bcl2l11<tm1Ast>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":30},"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6284,"B6Flpe","C57BL/6-Tg(ACTFLPe)9205Dym",null,"Dominant",{"$nulls":25},"transgene insertion 9205, Susan Dymecki","human ACTB promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6288,"HA-BBCD3","C57BL/6-Cd3e<tm1Mal> Ighm<tm1(Bcl6)Rdf> Prdm1<tm1Nutt>",null,"Semi-dominant","immunoglobulin heavy constant mu","Ighm","Increased","BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera","Ighm<tm1(Bcl6)Rdf>","MGI:3581517","12"]
[6293,"Lgr5/Tet GFP","Lgr5-rttA3-GFP/TRE GFP shLuc",{"$nulls":3}," Lgr5rta   Tet GFP  ",{"$nulls":35},"No speical monitoring required  This strain should not have any obvious phenotype without or with treatment of doxycycline. ",null,"FVB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6294,"B6/mb1cre","C57BL/6-Cd79a<tm1(Cre)Reth>",null,"Dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Nil","Cd79a, Ig alpha, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1 ","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a<tm1(cre)Reth>","MGI:3687451","7",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6299,"Mcl-1flox/Bcl-2","C57BL/6-Bcl2<tm1Sjk> Mcl1<tm3Sjk>",null,"Recessive","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3"]
[6304,"MTKN/H","MTKN/H",{"$nulls":3},"   Neo      hygro   ",{"$nulls":35},"Neomycin & Hygromycin resistant ",null,"Balb/c","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8621,"K5-creERt R26-YAP5SA","STOCK Gt(ROSA)26Sor<(CAGGS-Yap5SA,LacZ)Mao> Tg(KRT5-cre/ERT2)2Ipc",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",{"$nulls":3},"6",{"$nulls":16},"transgene insertion 2, I Pierre Chambon",{"$nulls":11},"Overexpression of activated YAP (NLS-YAP-5SA) with Keratin-5 (K5-CreERt) is sufficient to induce rapid formation of both SCC and spSCC in mice. spSCC tumours arise at sites of epithelial scratch wounding, where tumour-initiating epithelial cells undergo EMT to generate spSCC. Expression of the EMT transcription factor ZEB1 arises upon wounding and is a defining characteristic of spSCC in mice and humans. Thus, the wound healing response synergises with YAP to drive metaplastic transformation of SCC to spSCC.",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-12-18"]
[6314,"OT-II","C57BL/6-Tg(TcraTcrb)425Cbn/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Abnormal cytokine level:*CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Cryopreserved sperm"]
[6311,"Noxa/339","C57BL/6-Bcl2l11<tm1Ast> Pmaip1<tm1Ast>",null,"Recessive","phorbol-12-myristate-13-acetate-induced protein 1","Pmaip1","Nil","Noxa","MGI:1930146","phorbol-12-myristate-13-acetate-induced protein 1; targeted mutation 1, Andreas Strasser","Pmaip1<tm1Ast>","MGI:2681649","18"]
[6872,"A1f","C57BL/6-Acaca<tm1Dejs>/AusbApb","C57BL/6-Acaca<tm1Dejs>/Ausb","Dominant","acetyl-Coenzyme A carboxylase alpha","Acaca","Normal","A530025K05Rik, Acac, Acc1, acetyl-CoA carboxylase, LOC327983","MGI:108451",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-17","Cryopreserved sperm"]
[6318,"RaW","B6;129-Pdgfra<tm11(EGFP)Sor> Wt1<tm1(EGFP/cre)Wtp>",null,"Semi-dominant","platelet derived growth factor receptor, alpha polypeptide","Pdgfra","Normal","CD140a, Pdgfr-2","MGI:97530","platelet derived growth factor receptor, alpha polypeptide; targeted mutation 11, Philippe Soriano","Pdgfra<tm11(EGFP)Sor>","MGI:2663656","5"]
[6319,"PdxGFP","129S1/Sv-Pdx1<tm1Egs>",null,"Dominant","pancreatic and duodenal homeobox 1","Pdx1","Normal","IDX-1, IPF-1, Ipf1, Mody4, pdx-1, STF-1","MGI:102851","pancreatic and duodenal homeobox 1; targeted mutation 1, Edouard G Stanley","Pdx1<tm1Egs>","MGI:3688420","5",{"$nulls":30},"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6874,"DBC1 Clone 5C8B","C57BL/6-Dbc1<tm1>/Marp",null,"Recessive","deleted in bladder cancer 1 (human)","Dbc1",null,"Dbccr1, Fam5a","MGI:1928478",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-23","Cryopreserved sperm"]
[6327,"QkfTg-26","QkfBACRP23-360F23 Transgenic",{"$nulls":3},"   Qkf    ",{"$nulls":35},"Contact Researcher",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6332,"Spin","C57BL/6-Ptpn6<tm1Rsky>",null,"Recessive","protein tyrosine phosphatase, non-receptor type 6","Ptpn6","Nil","hcp, Hcph, Ptp1C, SHP-1, Spin","MGI:96055","protein tyrosine phosphatase, non-receptor type 6; targeted mutation 1, Klaus Rajewsky","Ptpn6<tm1Rsky>","MGI:3719625","6",{"$nulls":30},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6341,"1010","vav-Myc 10 x vav-Myc 10",{"$nulls":3}," vav-myc  ",{"$nulls":35},"Tumour development  T/+ mice develop thymoma or sub-cutaneous tumours (hystiocytic sarcoma) with a median onset of 41 weeks. T/T mice develop thymoma with a median onset of 13 weeks.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6343,"17/delmnt","vav-myc17/delmnt",{"$nulls":3},"  myc17    delmnt   ",{"$nulls":35},"Transgenic mice succumb to Lymphoma from 7 weeks of age.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5656,"C5L2 KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6358,"NOGIL2","NOD.Cg-Il2rg<tm1Wjl> Prkdc<scid>/SzJAusb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779 ","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency ","Prkdc<scid>","MGI:1857113","16"]
[6367,"M0DTRtg","C57Bl/6-tg(DTR)",{"$nulls":3},"DTR",{"$nulls":35},"Nil in absence of diptheria toxin",null,"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6390,"OT2tgTHY1cn40LKO","B6.Cg-Cd40lg<tm1Imx> Thy1<a> Tg(TcraTcrb)425Cbn/Ausb",null,"Recessive","CD40 ligand","Cd40lg","Nil","CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5","MGI:88337","CD40 ligand; targeted mutation 1, Immunex","Cd40lg<tm1Imx>","MGI:1857145","X",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Unknown","Unkown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6410,"Kaede","C57BL/6-tg(Kaede)<tm1>Rik/Ausb?",{"$nulls":3},"Kaede",{"$nulls":37},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6405,"TR3B?","B6.Cg-Cd19<tm1(cre)Cgn> Traf3<tm1Rbr>/JAusb",null,"Dominant","TNF receptor-associated factor 3","Traf3","Normal",null,"MGI:108041","TNF receptor-associated factor 3; targeted mutation 1, Robert Brink","Traf3<tm1Rbr>","MGI:3777324","12"]
[6399,"SAP KO","B6.129-Sh2d1a<tm1Pls>/Ausb",null,"X-linked","SH2 domain protein 1A","Sh2d1a","Nil","Duncan disease homolog, SAP","MGI:1328352","SH2 domain protein 1A; targeted mutation 1, Pamela L Schwartzberg","Sh2d1a<tm1Pls>","MGI:2388241","X",{"$nulls":28},"Decreased IgE level:*After immunization with ovalbumin, severe deficit in IgE is observed with little or no Ig E detected.Abnormal CD4-positive T cell physiology:*Pronounced defect in production of IL-4 upon stimulation with anti-CD3 or anti-CD3 plus anti-CD28.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8622,"Zeb1 fl K5-creERt R26-YAP5SA","STOCK Zeb1<tm1.1Mpst> Gt(ROSA)26Sor<(CAGGS-Yap5SA,LacZ)Mao> Tg(KRT5-cre/ERT2)2Ipc",null,"Recessive","zinc finger E-box binding homeobox 1","Zeb1","Unknown","3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a ","MGI:1344313","zinc finger E-box binding homeobox 1; targeted mutation 1.1, Marc Stemmler","Zeb1<tm1.1Mpst>","MGI:5901939","18"]
[1487,"B6.CCR-5-/-","B6.129P2-Ccr5<tm1Kuz>/AnuApb","B6.129P2-Ccr5<tm1Kuz>/AnuApb","Recessive","chemokine (C-C motif) receptor 5","Ccr5","Nil","CD195, Cmkbr5","MGI:107182","targeted mutation 1, William A Kuziel","Ccr5<tm1Kuz>","MGI:1861911","9",{"$nulls":15},"Yes",{"$nulls":12},"Decreased susceptibility to induced colitis:* null mice show clinically less severe DSS-mediated colitis than wild-type or Ccr2-nulls.Increased NK T cell number:* null mice show a significant increase in NK 1.1+ T cells by day 3 and 7 of DSS-treatment; wild-type and Ccr2-null mice do not show as large of an increase.Abnormal CD4-positive T cell morphology:* intestinal mucosa shows enhanced infiltration of CD4+ lymphocytes by day 7 compared to wild-type or Ccr2-deficient mice.* mice have an increased number of CD4+ T cells before and during DSS-induced colitis.Abnormal CD8-positive T cell morphology.Abnormal cytokine level:* mice expression one fifth the wild-type level of Ifng after day 3 and 7, while Il-4 is increased 75-fold and a 2-fold increase in Il-5 and -10 over wild-type.Impaired macrophage recruitment:* 80% fewer macrophages compared to control in Ag-loaded gelatin sponge DTH assay.* delay in induced peritoneal macrophage accumulation, however, accumulation of neutrophils/eosinophils is unchanged.Increased susceptibility to fungal infection:* reduced survival following inoculation with Cryptococcus neoformans, 40% die by week 8 due to CNS infection (hydrocephalus).* infected mice exhibit increased mononuclear cell recruitment to lungs, but not brain.* by week 5 infected mice exhibit cryptococcal meningitis ? cranial swelling, ruffled fur, staggered gait, lethargy and unresponsiveness, and decreased limb function.* brains of infected mice develop loss of neural tissue integrity , and large amounts of extracellelular cryptococcal polysaccharide capsule.Abnormal locomotor activity:* mice show little reduction in activity with DSS treatment, unlike wild-type which become very lethargic with time.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2007-07-02","Cryopreserved sperm"]
[8623,"Lats1 fl Lats2 fl K5-creERT2","STOCK Lats1<tm1.1Jfm> Lats2<tm1.1Jfm> Tg(KRT5-cre/ERT2)2Ipc",null,"Recessive","large tumor suppressor 2","Lats2",null,null,"MGI:1354386","large tumor suppressor 2; targeted mutation 1.1, James F Martin","Lats2<tm1.1Jfm>","MGI:5568589","14"]
[6461,"AdqCre","B6.Cg-Tg(Adipoq-cre)#Pesch/Ausb",null,"Dominant",{"$nulls":25},"Transgene insertion, Philipp E Scherer; transgene insertion, Philipp E Scherer","adiponectin promoter",{"$nulls":10},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6462,"D2B","B6.129P2-Doc2b<tm1Aljg>/Ausb?",null,"Recessive","double C2, beta","Doc2b","Nil",null,"MGI:1100497","double C2, beta; targeted mutation 1, Alexander J Groffen","Doc2b<tm1Aljg>","MGI:4440451","11",{"$nulls":28},"Abnormal CNS synaptic transmission:*Purkinje cells exhibit continuous spiking without interruption unlike wild-type cells.      Abnormal inhibitory postsynaptic currents:        *Spontaneous inhibitory postsynaptic currents are decreased to one-fourth of wild-type.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6464,"HSAcre","B6.Cg-Tg(ACTA1-cre)/Ausb ?",null,"Dominant",{"$nulls":25},"Cre recombinase","Human Skeletal Actin Promoter","skeletal muscle",{"$nulls":11},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6494,"PRLACZKI","B6.Cg-Pgr<tm1Lyd>/Ausb",null,"Dominant","progesterone receptor","Pgr","Normal","9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 1, John P Lydon","Pgr<tm1Lyd>","MGI:3032652","9",{"$nulls":28},"Unknown","Unknown","129/B6","Yes","No","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7596,null,"SJL/ASAM<MRI32207>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","8",null,null,"No","2014-02-18","Cryopreserved sperm"]
[6531,"IL15?","B6.Cg-Il15<tm1Imx>/ScrAusb",null,"Recessive","interleukin 15","Il15","Nil",null,"MGI:103014","nterleukin 15; targeted mutation 1, Immunex Research and Development Corporation","Il15<tm1Imx>","MGI:2136897","8",{"$nulls":28},"Abnormal dendritic cell physiology:*In culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6527,"FoxDT","B6.Cg-Foxp3<tm3Ayr>/TacAusb?",null,"Dominant","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 3, Alexander Y Rudensky","Foxp3<tm3Ayr>","MGI:3698131","X",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6541,"PKCT?","B6.129P2-Prkcq<tm1Litt>/ScrAusb?",null,"Recessive","protein kinase C, theta","Prkcq","Nil","A130035A12Rik, PKC theta, PKC-0, PKC-theta, Pkcq, PKCtheta","MGI:97601","protein kinase C, theta; targeted mutation 1, Dan Littman","Prkcq<tm1Litt>","MGI:2664379","2",{"$nulls":28},"Immune system phenotype:*Mice exhibit normal lung inflammation driven by Th1 cytokines.      Abnormal T-helper 1 cell differentiation:      *Th1 stimulated T cells exhibit delayed differentiation and accumulation compared with similarly treated wild-type cells.      *However, Th1 cytokine production is normal in antigen airway challenge.      Decreased T cell proliferation:      *In mice immunized with ovalbumin in alum.      *However, proliferation of T cells in mice stimulated with ovalbumin and complete Freund's adjuvant is normal.      Decreased splenocyte proliferation:      *On day 14, but not day 21, following induction of experimental autoimmune encephalomyelitis (EAE).      Abnormal CD4-positive T cell physiology:      *Accumulation of antigen-induced CD4 cells in lung draining lymph nodes during Th2 lung inflammation is decreased compared to in similarly treated wild-type mice.         Abnormal T-helper 2 physiology:         *Following ovalbumin challenge, production of Th2 cytokines (Il4, Il5, and Il13) compared to in similarly treated wild-type mice.         *Stimulated CD4 T cells exhibit impaired early Th2 and Th1 differentiation compared with similarly treated wild-type cells.      Decreased interferon-gamma secretion:      *From CD4 T cells stimulated by anti-CD3, anti-CD28 antibodies but not when IL2 was present.      *From CD4 T cells from mice stimulated subcutaneously with ovalbumin and complete Freund's adjuvant.      *Following induction of experimental autoimmune encephalomyelitis (EAE).      Decreased interleukin-13 secretion:      *In the bronchoalveolar lavage fluid of ovalbumin challenged mice.      Decreased interleukin-17 secretion:      *Following induction of experimental autoimmune encephalomyelitis (EAE), splenocytes produce less IL17 compared to in similarly treated wild-type mice.      *IL23-stimulated spleen cultures produce less IL17 compared with similarly treated wild-type cultures.      *However, ovalbumin-stimulated splenocytes exhibit normal IL17 production.      Decreased interleukin-2 secretion:      *From CD4 T cells from mice stimulated subcutaneously with ovalbumin and complete Freund's adjuvant.      *From splenocytes on day 14, but not day 21, following induction of experimental autoimmune encephalomyelitis (EAE).      Decreased interleukin-4 secretion:      *In the bronchoalveolar lavage fluid of ovalbumin challenged mice.      *From CD4 T cells stimulated by anti-CD3, anti-CD28 antibodies with or without IL2.      *From CD4 T cells from mice stimulated with ovalbumin in alum.      *From splenocytes on day 14, but not day 21, following induction of experimental autoimmune encephalomyelitis (EAE).      Decreased interleukin-5 secretion:      *In the bronchoalveolar lavage fluid of ovalbumin challenged mice.      *From CD4 T cells from mice stimulated with ovalbumin in alum.      Decreased susceptibility to experimental autoimmune encephalomyelitis:      *Mice treated with MOG35-55 are completely resistance to experimental autoimmune encephalomyelitis (EAE) induction (reduced inflammation, no demyelinating lesions, decreased production of Th1 cytokines IFN-gamma, IL2, and IL4, and IL17 production) compared with similarly treated wild-type mice.Decreased airway responsiveness:*Mice exhibit attenuated methacholine sensitivity compared with similarly treated wild-type mice.Abnormal nervous system development:*Developmental dennervation of polyinnervated neuromuscular junctions is delayed compared to in wild-type mice.Abnormal neuromuscular synapse morphology:*In a twitch assay, PMA-treated muscles even with normal nerves and glia in the preparation fail to exhibit synapse loss unlike similarly treated wild-type muscles.*In a twitch assay, PMA-treated neurons with normal muscles and glia in the preparation fail to exhibit synapse loss unlike similarly treated wild-type muscles.Abnormal endplate potential:*Following stimulation, myotubes fail to exhibit a decrement in endplate potential (EPP) amplitude unlike in similarly treated wild-type cells.*Following PMA treatment, muscles with wild-type nerves and glia or ventral spinal cord nerves with wild-type muscles and glia fail to exhibit a decrease in endplate amplitude compared with similarly treated wild-type muscles.*However, ventral spinal cord neurons treated with PMA and TTX exhibit a normal decrease in EPP amplitude.Decreased physiological sensitivity to xenobiotic:*Mice exhibit attenuated methacholine sensitivity compared with similarly treated wild-type mice.*Ovalbumin-treated mice exhibit a reduction in accumulation of leukocytes, including eosinophils and lymphocytes, in bronchoalveolar lavage fluid and lung tissue, relatively normal bronchial epithelium, reduced mucus, and reduced Th2 cytokines compared with similarly treated wild-type mice.","Abnormal neuromuscular synapse morphology:*PMA-treated neurons with normal muscles and glia in the preparation fail to exhibit synapse loss unlike similarly treated wild-type muscles that is not as severe as in samples from homozygotes.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6551,"CONB6KI","CONEDKIxto B6",null,"Recessive",null,"CONED",{"$nulls":37},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6557,"GAPB6f","ROSA26GAP x B6",null,"Recessive",null,"GAPB6",{"$nulls":37},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[6572,"R6EΔ","GR6ΔECS",null,"Recessive",null,"R6E",{"$nulls":38},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo"]
[6574,"THGtg","hTHGFPTg",null,"Dominant",null,"THG",{"$nulls":6},"Unknown",{"$nulls":30},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6563,"GR7S6?","GR7S6?",null,"Recessive",null,"GR7S6",{"$nulls":37},"SVEV","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3484,"uMT","C57BL/6-Igh-6<tm1Cgn>/Wehi",null,"Recessive","immunoglobulin heavy chain 6 (heavy chain of IgM)","Igh-6","Nil","BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","targeted mutation 1, University of Cologne","Igh-6<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"Yes",{"$nulls":12},"B cell deficient and therefore immuno-compromised (no immunoglobulin but CTL intact).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23"]
[5306,null,"C57BL/6-Mrc1<tm1Mnz>",null,"Recessive","mannose receptor, C type 1","Mrc1","Nil","CD206, MR","MGI:97142","mannose receptor, C type 1; targeted mutation 1, Michel C Nussenzweig","Mrc1<tm1Mnz>","MGI:2448258","2",{"$nulls":15},"No",{"$nulls":12},"Defective macrophage function.MR-/- mice were defective in clearing proteins bearing accessible mannose and N-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05"]
[4869,"B6.HTF1.Tg","C57BL/6-Tg(H2-K-huFUT1)1/Apb",null,"Dominant",{"$nulls":25},"human fucosyltransferase 1","H2-K<b>","All blood/tissue samples express human fucosyltransferase 1",{"$nulls":9},"Attempts to breed homozygous animals failed. Unknown if homozygous transgene expression is embryonic lethal.","All blood/tissue samples express human fucosyltransferase.Develop colitis from 6 weeks of age, skin disease from around 12 weeks of age, highly susceptible to infections such as MHV.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-28","Cryopreserved sperm"]
[5713,"CYP 26 KO ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5551,"Krüppel-like Factor 8 (Klf8) Knockout ","FVB/N.129P2-Klf8<Gt(AD0101)Wtsi>/Apb",null,"X-linked","Kruppel-like factor 8","Klf8","Nil",null,"MGI:2442430","Kruppel-like factor 8; gene trap AD0101, Wellcome Trust Sanger Institute","Klf8<Gt(AD0101)Wtsi>","MGI:4331301","X",{"$nulls":15},"Yes",{"$nulls":12},"Largely normal.Some mice by 6 months of age.Mice exhibit normal full blood counts indicating normal erythroid parameters and platelet numbers and normal response to phenylhydrazine treatment ","Normal.Premature death: • some mice by 6 months","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-08-09","Cryopreserved sperm"]
[5541,"ENU18Ch:065a","C57BL/6JAnu-Fcer2a<m1Anu>/AnuApb","C57BL/6JAnu-Fcer2a<m1Anu>/AnuApb","Dominant","Fc receptor, IgE, low affinity II, alpha polypeptide","Fcer2a ","Reduced","CD23, FC epsilon RII, Fce2, low-affinity IgE receptor, Ly-42 ","MGI:95497","Fc receptor, IgE, low affinity II, alpha polypeptide; mutation 1, The Australian National University","Fcer2a<m1Anu>","MGI:5563468","8","ENSMUSG00000005540","ENSMUST00000005678","fcer2a-201","54","226","C to A","ENSMUSE00000484893","3","18","Cysteine to STOP",{"$nulls":4},"TACTGGGAACCTCCTAGAAAGCGTTGCTGCTGTGCAAGACGTGGGACACAGCTCATGTTGG",{"$nulls":13},"Reduced CD23 protein expression on B cells in peripheral blood. ","Reduced CD23 protein expression on B cells in peripheral blood. ","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","6","4","Sib x sib","No","2011-07-18","Cryopreserved sperm"]
[5716,"D SOX",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5717,"D-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[224,"11Bal","C57BL/6-Trp53<In(11Trp53;11Wnt3)8Brd>",null,"Semi-dominant",{"$nulls":37},"Die in utero. Wildtype are black.Tumour incidence is similar to other Trp53 alleles.","Pale ears and tail but have black fur.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25"]
[6586,"MMP13KO BALB/c","C.FVB(Cg)-Mmp13<tm1.1Werb>/Apb",null,"Recessive","matrix metallopeptidase 13","MMP13","Nil","Clg, collagenase-1, Collagenase-3, interstitial collagenase, MMP-13, Mmp1","MGI:1340026","matrix metallopeptidase 13; targeted mutation 1.1, Zena Werb","Mmp13<tm1.1Werb>","MGI:3521938","9",{"$nulls":28},"Increased width of hypertrophic chondrocyte zone: * the hypertrophic zone is expanded in the tibia and metatarsals, at E17 and 1 week after birth, respectively, however by 12 weeks of age the size of the hypertrophic zone is similar to wild-type. * chondrocytes proliferate and differentiate normally but accumulate in the most terminally differentiated hypertrophic state. * establishment of the primary ossification centers is normal.Abnormal cancellous bone morphology: * the amount of trabecular bone is increased in the tibia and metatarsals by 3 weeks or 1 week of age, respectively, however by 1 year of age the amount of trabecular bone was similar to wild-type. * the organization of the trabecular bone is also irregular.OA was surgically induced in the knees of MMP-13-knockout mice. No difference between wildtype and KO mice for aggrecan loss or cartilage erosion at 4 weeks. here was less tibial cartilage erosion in knockout mice than in wild-type mice at 8 weeks. Cartilaginous osteophytes were larger in knockout mice at 4 weeks, but by 8 weeks osteophyte maturity and size were no different from those in wild-type mice. Articular chondrocyte hypertrophy with positive type X collagen and DIPEN staining occurred in both wild-type and knockout mouse joints. Authors conclude Chondrocyte hypertrophy is not regulated by MMP-13 activity in this model and does not in itself lead to cartilage erosion. MMP-13 deficiency can inhibit cartilage erosion in the presence of aggrecan depletion, supporting the potential for therapeutic intervention in established OA with MMP-13 inhibitors.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,"Het x Het","No","2011-09-22","Cryopreserved sperm"]
[8631,"TLR9 ApoE double knock out mice","C57BL/6-Apoe<tm1Unc> Tlr9<tm1Aki>",null,"Recessive","apolipoprotein E","Apoe","Nil",null,"MGI:88057","apolipoprotein E; targeted mutation 1, University of North Carolina","Apoe<tm1Unc>","MGI:1857129","7",{"$nulls":28},"Genetic deletion of the innate immune receptor TLR9 exacerbated atherosclerosis in ApoE−/− mice fed a high-fat diet. CD4+ T cells were identified as potential mediators of this effect.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-12-19","Cryopreserved sperm"]
[7304,"PbT-II-129","C57BL/6-Tg(H-2K<b>-TcraD78TcrbD78)129Cbn/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 129, Francis Carbone","H-2Kb",{"$nulls":10},"Majority of CD4 T cells express the transgenic T cell recepter Va2Vb12 specific for Plasmodium berghei (Pb) parasites.","As for homozygous","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,"4","brother-sister or Tg positive to C57BL/6","No","2013-04-05","Cryopreserved sperm"]
[1549,null,"BALB/c-Tg(iFABPp-IL9)/AnuApb",null,"Recessive",{"$nulls":25},"interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm"]
[8633,"Katnal2 Flox","C57BL/6N-Katnal2<tm1c(EUCOMM)Wtsi>/MarpApb",null,"Recessive","katanin p60 subunit A-like 2","Katnal2",null,"3110023G01Rik, 4933439B08Rik","MGI:1924234","katanin p60 subunit A-like 2; targeted mutation 1c, Wellcome Trust Sanger Institute","Katnal2<tm1c(EUCOMM)Wtsi>","MGI:6164199","18",{"$nulls":28},"Normal","Normal","C57/BL6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-01-10","Cryopreserved sperm"]
[6838,"APN 228","C57Bl/6N-mir-196a-2<puDtk(Wtsi)>/MarpApb",null,"Recessive","microRNA 196a-2 ","Mir196a-2 ","Unknown","mir 196a-2, Mirn196a-2, mmu-mir-196a-2","MGI:3618739",{"$nulls":3},"15",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-03-07","Cryopreserved sperm"]
[5660,"CamK",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6609,"BXD-96","BXD96/RwwJArc",null,"Recessive",{"$nulls":37},"Normal","Normal","C57BL/6J x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"brother x sister","No","2011-10-04","Embryo"]
[6416,"G14Δ","B6.129SV-Grb14<tm1Daly>/Ausb",null,"Dominant","growth factor receptor bound protein 14","Grb14","Normal",null,"MGI:1355324","growth factor receptor bound protein 14; targeted mutation 1, Roger J Daly","Grb14<tm1Daly>","MGI:3029164","2",{"$nulls":28},"Improved glucose tolerance:*Males exhibit increased glucose tolerance between 16 and 24 weeks of age.*Circulating level of insulin is lower in males in response to the same glucose load.*Males exhibit an increase in glucose incorporation into tissue glycogen.Increased insulin sensitivity:*Decrease in blood glucose than wild-type males.*Fasting plasma insulin levels in males are lower at 28-30 and 54-56 weeks of age.*Male skeletal muscle and liver exhibits enhanced insulin-induced glucose uptake.Increased heart weight:*28 week old males exhibit an 18% increase in heart weight.Decreased body weight:*Small but significant decrease in body weight for both males (5-10%) and females (5%).Decreased spleen weight:*28 week old males exhibit a disproportionate decrease (29%) in spleen weight.Decreased liver weight:*28 week old males exhibit a disproportionate decrease (16%) in liver weight.",null,"B6/129SV","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7391,"B6.pIgR-/-","C57BL/6-Pigr<tm1Rast>/Apb",null,"Recessive","polymeric immunoglobulin receptor","Pigr","Nil",null,"MGI:103080","polymeric immunoglobulin receptor; targeted mutation 1, Richard A Strugnell","Pigr<tm1Rast>","MGI:2651659","1",{"$nulls":28},"These mice are unable to secrete IgA and IgM into the secretions.  This results in 50-100 fold increased levels of IgA in blood, and very low to undetectable levels of IgA in faecal samples.","normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"Yes","2013-08-06","Cryopreserved sperm"]
[6755,"P2X2KO","B6.129-P2rx2<tm1Ckn>/J/Ausb",null,"Recessive","purinergic receptor P2X, ligand-gated ion channel, 2 ","P2rx2","Nil","P2x2, P2X2a ","MGI:2665170","purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Debra A Cockayne ","P2rx2<tm1Ckn>","MGI:2687349","5",{"$nulls":28},"Decreased pulmonary ventilation:*In response to hypoxia (10% O2), adult homozygotes (4-6 months of age) display a significantly reduced ventilatory response showing an increase of only 261 +/- 202 ml/min/kg in minute ventilation (VE) relative to 1008 +/- 154 ml/min/kg in wild-type controls.*In response to further hypoxia (7.5% O2), homozygotes display a severe ventilatory depression with the VE reduced below prehypoxic levels by 606 +/- 209 ml/min/kg, unlike wild-type controls where no additional increase in ventilation is observed but the VE remains above normoxic levels.*However, adult homozygotes display normal resting ventilation during normoxia and show normal ventilatory responses to a mild (15% O2) hypoxia relative to wild-type controls.Abnormal carotid body physiology:*Homozygotes show a dramatic reduction in afferent nerve responses of the carotid sinus nerve to a decrease in oxygen tension (PO2).*Unlike in in vitro carotid body-sinus nerve preparations from wild-type mice where sinus nerve discharge increases from baseline to a peak of 130.82 +/- 10.79 spikes/sec during hypoxia, the afferent discharge in preparations from mutant mice only reaches a peak of 58.13 +/- 9.40 spikes/sec, indicating that carotid body function is impaired.*The average peak firing rate of single units induced by hypoxia is significantly lower in carotid body-sinus nerve preparations from mutant mice (1.64 +/- 0.11 spikes/sec) relative to that observed in wild-type preparations (7.96 +/- 0.88 spikes/sec).Homeostasis/metabolism phenotype:*In response to hypoxia (7.5% O2), adult homozygotes display normal decreases in body temperature relative to wild-type controls (0.9 +/- 0.2 vs 0.8 +/- 0.1 degress Celsius, respectively).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[7393,"B6.TLR4 0/0","B6.C3-Tlr4<Lps-d>/Apb",null,"Semi-dominant",{"$nulls":28},"toll-like receptor 4","Tlr4",null,"lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; defective lipopolysaccharide response","Tlr4<Lps-d>","MGI:1857718","4","The Lps-d allele renders the animals endotoxin-resistant. ","unknown","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent","13",null,null,"Yes","2013-08-06","Cryopreserved sperm"]
[255,null,"B6,129-Csf3<tm1Ard>",null,"Recessive","colony stimulating factor 3 (granulocyte)","Csf3","Nil","Csfg, G-CSF, MGI-IG","MGI:1339751","targeted mutation 1, Ashley R Dunn","Csf3<tm1Ard>","MGI:1857155","11",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice were viable and fertile, with no overt signs of disease. They suffered, however, a severe neutropenia, with blood neutrophil levels in homozygotes 20 to 30% of those in normal mice, and intermediate levels in heterozygotes. Granulocyte precursor cell levels were reduced 50% in homozygotes, and the ability of these mice to resist Listeria monocytogenes infections was reduced (J:20400).","Decreased neutrophil cell number (chronic neutropenia).","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-28"]
[331,null,"B6,129-Tgfa<tm1Ard>",null,"Semi-dominant","transforming growth factor alpha","Tgfa","Unknown",null,"MGI:98724","targeted mutation 1, Ashley R Dunn","Tgfa<tm1Ard>","MGI:1856577","6",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants have curly vibrissae, wavy hair with misaligned hair follicles, reduced body weight, and eye defects including open eyelids at birth, corneal scarring and microphthalmia.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-05"]
[8640,"Swiss:Orange","Swiss Webster Outbred:Orange",null,"Dominant",{"$nulls":37},"Normal.High fecundity, excellent mothers, ideal for recipients.",null,"Swiss Webster","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-01-15"]
[256,null,"B6,129-Csf2<tm1Ard>",null,"Recessive","colony stimulating factor 2 (granulocyte-macrophage)","Csf2","Nil","Csfgm, Gm-CSf, MGI-IGM","MGI:1339752","targeted mutation 1, Ashley R Dunn","Csf2<tm1Ard>","MGI:1930997","11",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality.  Appearance of lungs resembles alveolar proteinosis. Lung pathology renders these mice susceptible to opportunistic bacterial and fungal lung infection. If mice are kept in hooded boxes they should be OK for at least 10 months.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-28"]
[7598,"Stk35KO or Clik1KO","B6.129-Stk35<tm1>/MarpApb",null,"Semi-dominant","serine/threonine kinase 35 ","Stk35","Nil","1700054C12Rik, CLIK1, CLP-36 interacting kinase","MGI:1914583",{"$nulls":3},"2",{"$nulls":28},"Male and female subfertility/infertility and abnormal eye development","Variable from subfertility to normal.","SV129/C57Bl6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",{"$nulls":3},"No","2014-02-19","Cryopreserved sperm"]
[6798,"TRAMPtg","C57BL/6-Tg(TRAMP)8247Ng/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 8247, Norman M Greenberg ","probasin","Expression of the SV40 early region tumor antigen was driven in mouse prostrate epithelium ",{"$nulls":9},"Unknown","Progressive forms of prostate cancer with distant site metastasis as early as ten weeks of age. (8.2 pre-weaning loss).","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","20+ generations",null,"hemizygous females with C57BL/6 males","No","2012-01-19"]
[7687,"ENU26:017:Mef2c","C57BL/6NCrlAnu-Mef2c<m1Anu>/AnuApb",null,"Recessive","myocyte enhancer factor 2C","Mef2c","Unknown","5430401D19Rik, 9930028G15Rik","MGI:99458","myocyte enhancer factor 2C; mutation 1, The Australian National University","Mef2c","MGI:5571303","13","ENSMUSG00000005583","ENSMUST00000163888","Mef2c-202","374","952","A to T","ENSMUSE00000680752","5","125","Aspartic acid to Valine",{"$nulls":4},"CAAGTACAGGAAAATTAACGAAGATATTGATCTAATGATCAGCAGGCAAAGATTGTGTGCT",{"$nulls":13},"Embryonic Lethal","Appear normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"G5","Het x Het","No","2014-05-22","Cryopreserved sperm"]
[8643,"Dap10/Dap12 double knock out (Dap10/12 DKO)","B6.129-Hcst/Tyrobp<tm1Ttk>/Ttk",null,"Recessive","TYRO protein tyrosine kinase binding protein","Tyrobp","Nil","DAP12, KARAP, killer cell activating receptor associated protein","MGI:1277211","TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai","Hcst/Tyrobp<tm1Ttk>","MGI:3840567","7"]
[8644,"p60 flox","C57BL/6N-Katna1<tm1c(KOMP)Wtsi>/MarpApb",null,"Recessive","katanin p60 (ATPase-containing) subunit A1","Katna1","Nil",null,"MGI:1344353","katanin p60 (ATPase-containing) subunit A1; targeted mutation 1a, Wellcome Trust Sanger Institute","Katna1<tm1a(KOMP)Wtsi>","MGI:4458514","10",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal","Normal","C57BL/6N","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-01-24","Cryopreserved sperm"]
[5669,"CCSP-rt/TA/Tet0-NFIen ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5670,"CD1/Z Red",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7602,null,"SJL/ASAM<MRI120382>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Normal","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","2",null,null,"No","2014-02-24","Cryopreserved sperm"]
[6804,"Nox2 / ApoE KO","B6.129-Apoe<tm1Unc> Cybb<tm1Din>/MarpApb",null,"Recessive","cytochrome b-245, beta polypeptide","Cybb","Nil","Cgd, gp91<phox>, gp91phox, Nox2","MGI:88574","cytochrome b-245, beta polypeptide; targeted mutation 1, Mary C Dinauer","Cybb<tm1Din>","MGI:1857284","X"]
[6894,"GSTA3-/-","BALB/c-Gsta3<tm1Pbrd>/AnuApb",null,"Recessive","glutathione S-transferase, alpha 3","GstA3","Nil","Gst2-3","MGI:95856",{"$nulls":3},"1",{"$nulls":28},"Altered metabolism of aflatoxinB1","Unknown","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","N4",null,"homozygote matings","No","2012-05-11","Cryopreserved sperm"]
[7044,"Activin BA knockout ; Inhba-/-","B6;129S7-Inhba<tm1Zuk>/MarpApb",null,"Dominant","inhibin beta-A","Inhba",null,"activin","MGI:96570","inhibin beta-A; targeted mutation 1, Martin M Matzuk","Inhba<tm1Zuk>","MGI:1861957","13",{"$nulls":28},"Mice die at birth due to abnormal palate development, precluding feeding.","Delayed onset of fertility, no impact on general viability","C57BL/6 x 129S","No","No","Yes","No","No","Yes","Yes","Good","Unknown",null,"Heterozygous matings","No","2012-08-06","Cryopreserved sperm"]
[8646,"EGFL6 global KO","B6.129X1-Egfl6<Gt9485H8)Cmgd>",null,"Recessive","EGF-like-domain, multiple 6","Egfl6",null,"Maeg","MGI:1858599","EGF-like-domain, multiple 6; gene trap 485H8, Centre for Modeling Human Disease","Egfl6<Gt(485H8)Cmhd>","MGI:4954036","X",{"$nulls":28},"Unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-01-24","Cryopreserved sperm"]
[5554,"N1A-dko","Nox1-ApoE double knockout mouse",null,"Recessive","NADPH oxidase 1","Nox1","Unknown","GP91 phox homolog, Nox-1","MGI:2450016",{"$nulls":3},"X",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2011-08-11","Cryopreserved sperm"]
[5097,"Hic1lox","C57BL/6-Hic1<tm1Dnw>/MarpApb",null,"Dominant","Hypermethylated in Cancer-1","Hic1","Normal",null,"1338010","Hic1lox","Hic1<tm1Dnw>",null,"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"homozygote to homozygote","No","2010-04-27","Cryopreserved sperm"]
[8647,null,"ENU43:345:Casp1",null,"Recessive","Casp1",{"$nulls":7},"Unknown",{"$nulls":30},"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-01-25","Cryopreserved sperm"]
[4943,"osteocalcin-cre","C57BL/6-Tg(BGLAP-cre)1Clem/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Thomas L Clemens","human osteocalcin (BGLAP) promoter","Osteoblasts",{"$nulls":10},"Normal.Cre recombinase expression restricted to osteoblasts.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2009-12-04","Cryopreserved sperm"]
[5201,"GOSSIP","C57BL/6J-Zfp397<tm1>",null,"Recessive","zinc finger protein 397","Zfp397","Nil",null,"MGI:1916506",{"$nulls":3},"18",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-08-05","Cryopreserved sperm"]
[7312,"R26-Confetti","B6J.129P2-Gt(ROSA)26Sor<tm1(CAG-Brainbow2.1)Cle>/JApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hans Clevers","Gt(ROSA)26Sor<tm1(CAG-Brainbow2.1)Cle>","MGI:4835542","6",{"$nulls":28},"none - reporter mouse","none - reporter mouse","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","obtained from Jackson Lab as a C57Bl/6 backcrossed line (stock number 017492)",null,null,"No","2013-04-10","Cryopreserved sperm"]
[8649,"ENU45:G3","ANU:ENU45:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2019-01-31","Cryopreserved sperm"]
[7355,"MommeR1","FVB-Foxo3<MommeR1>/QimrAnuApb",null,"Recessive","forkhead box O3","Foxo3","Unknown","Fkhr2, FKHRL1, Foxo3a","MGI:1890081","modifier of murine metastable epialleles, R1","Foxo3<MommeR1>",null,"10",{"$nulls":15},"Yes","Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Percentage of cells expressing the Line3 GFP transgene is decreased (enhancer of variegation).",null,"FVB/NJ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Poor",null,null,"MommeD5<+/->;Tg(α-Globin-GFP)3EWh<tg/tg> x Tg(α-Globin-GFP)3EWh<tg/tg>","No","2013-06-19","Cryopreserved sperm"]
[5105,"APN23, RRR232","B6;129-Tbc1d15<Gt(RRR232)Byg>/Marp",null,"Recessive","TBC1 domain family, member 15","Tbc1d15","Unknown","Ly6dl","MGI:1913937","TBC1 domain family, member 15; gene trap RRR232, BayGenomics","Tbc1d15<Gt(RRR232)Byg>","MGI:4397430","10",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-04-30","Cryopreserved sperm"]
[5148,null,"Crisp3 Knockout",null,"Recessive","cysteine-rich secretory protein 3","Crisp3",null,"Aeg2, CRISP-3, CRS3, SGP28","MGI:102552",{"$nulls":3},"17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Unknown","C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-06-08","Cryopreserved sperm"]
[5155,"APN 22 ;RRR502, TBC1D1","B6;129-tbc1d1<Gt(RRR502)Byg>/Marp",null,"Recessive","TBC1 domain family, member 1","TBC1D1","Unknown",null,"1889508","TBC1 domain family, member 1; gene trap RRR502, BayGenomics","Tbc1d1<Gt(RRR502)Byg>","MGI:4330552","5",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2010-06-17","Cryopreserved sperm"]
[5534,"Chuzhoi","B6;C-Ptk7<chz>/Apb",null,"Recessive","protein tyrosine kinase 7","Ptk7","Reduced","hz, mPTK7/CCK4","MGI:1918711","PTK7 protein tyrosine kinase 7; chuzhoi","Ptk7<chz>","MGI:3640803","17",{"$nulls":28},"Homozygouse mice do not survive past birth. They suffer from impaired neural tube, heart and lung development, rib defects, polydactyly, failed eyelid closure and altered cell polarity.","normal","C57BL/6","No","No","Yes","No","No","Yes","Yes","Good",null,null,"+/- x +/+","No","2011-07-07","Cryopreserved sperm"]
[5221,"GRQ","B6.129-Fxn<tm1Mkn> Tg(FXN-EGFP)CSars/Apb","SARS","Recessive","frataxin","Fxn",null,"Frda","MGI:1096879","frataxin; targeted mutation 1, Michel Koenig","Fxn<tm1Mkn>","MGI:2177162","19",{"$nulls":15},"No","Human FRATAXIN gene","FXN endogenous promoter",{"$nulls":10},"Homozygous FXN-EGFP transgene: Normal.Homozygous Fxn knockout: embryonic lethal, but completely complemented by presence of FXN-EGFP transgene.","Hemizygous FXN-EGFP transgene: Normal.Heterozygous Fxn knockout: Normal.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16","Hemizygous FXN-EGFP transgene X Homozygous FXN knockout","Yes","2010-09-23","Cryopreserved sperm"]
[4973,"DSCR1 P77 Tg","B6.CBA-Tg(RCAN1)77Mapr/MarpApb",null,"Dominant",{"$nulls":25},"human regulator of cacineurin 1","RCAN1","low",{"$nulls":9},"Transgenics are indistinguishable from wild type animals","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Homozygous Tg x Homozygous Tg","No","2010-01-22","Cryopreserved sperm"]
[8653,"HRGKO","C57BL/6-Hrg<tm1>",null,"Recessive","histidine-rich glycoprotein","Hrg","Nil","D16JH2, D18020","MGI:2146636","HRG",null,null,"16",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-02-08","Cryopreserved sperm"]
[5513,"prkfl/fl","C57BL/6-Prkar1a<flHua>/Apb",null,"Dominant","protein kinase, cAMP dependent regulatory, type I, alpha","Prkar1a","Normal","RIalpha, Tse-1, Tse1","MGI:104878",{"$nulls":3},"11",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","More than 10",null,null,"No","2011-05-25","Cryopreserved sperm"]
[7605,"Rbm5 KO","B6.129P2-Rbm5<Gt(PST20293)Mfgc>/Marp",null,"Recessive","RNA binding motif protein 5","Rbm5","Unknown",null,"MGI:1933204","RNA binding motif protein 5; gene trap PST20293, Mammalian Functional Genomics Centre","Rbm5<Gt(PST20293)Mfgc>","MGI:3902497","9",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","C57BL/6 x 129P2/OlaHsd","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","13",null,null,"No","2014-02-27"]
[5098,"VR1 knock out","B6.129X1-Trpv1<tm1Jul>/JApb",null,"Recessive","transient receptor potential cation channel, subfamily V, member 1","Trpv1","Nil","capsaicin receptor, OTRPC1, VR-1, Vr1","MGI:1341787","transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1, David Julius","Trpv1<tm1Jul>","MGI:1934023","11",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutant mice demonstrate abnormal nociception, abnormal anxiety- and conditioning-related behaviors, increased sensitivity to DOCA-salt-induced renal damage, resistance to diet-induced obesity, altered taste sensitivity, and impaired febrile response.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-04-27","Cryopreserved sperm"]
[8656,"LMR","B6.Cg-Msh2<tm1Ndw> Rag1<tm1Bal> Tg(IgkHyHEL10)1Rbr/Cjo",null,"Recessive","mutS homolog 2","Msh2",null,null,"MGI:101816",{"$nulls":3},"17",{"$nulls":16},"transgene insertion 1, Robert Brink",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-02-15","Cryopreserved sperm"]
[6650,"APN 119","C57BL/6N-PYY<tm1(KOMP)Wtsi>/Marp",null,"Recessive","peptide YY ","Pyy ",null,"MGC:19143 ","MGI:99924 ","peptide YY; targeted mutation 1, Wellcome Trust Sanger Institute ","Pyytm1(KOMP)Wtsi","MGI:4363090","11",{"$nulls":28},"Unknown - Not bred to homozygocity","Normal","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-11-22","Cryopreserved sperm"]
[5128,"152","B6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz",null,"Dominant",{"$nulls":25},"transgene insertion 152H, Laurence Ozmen","Thy1 promoter driving expression of the human APP ; Prnp promoter driving the expression of human PSEN2",{"$nulls":11},"Abnormal spatial learning: * in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice. * in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice.Impaired coordination: on at rotarod at 4 months.Amyloid beta deposits: * from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice. * amyloid beta deposits worsen with age.Increased body weight: at 4 to 12 months","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-05-20","Cryopreserved sperm"]
[5230,"Mincle F / MNB","C57BL/6J-Clec4e<tm1Psob>/Apb",null,"Semi-dominant","C-type lectin domain family 4, member e","Clec4e","Nil","Clecsf9, Mincle","MGI:1861232","C-type lectin domain family 4, member e; targeted mutation 1, Peter Sobieszczuk","Clec4e<tm1Psob>","MGI:3618604","6",{"$nulls":15},"Yes",{"$nulls":12},"Approx 20% decrease in white blood cell count, though still within normal range. Heart valves with increased amounts of extracellular matrix.","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","not known","4 years",null,"No","2010-10-06","Cryopreserved sperm"]
[5226,"APN 55","C57BL/6N-Hsd11b1<tm1a(KOMP)Wtsi",null,"Recessive","hydroxysteroid 11-beta dehydrogenase 1","Hsd11b1","Nil","11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1","MGI:103562","hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1a, Wellcome Trust Sanger Institute","Hsd11b1<tm1a(KOMP)Wtsi>",null,"1",{"$nulls":15},"No",{"$nulls":12},"Unknown","Normal","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Excellent",null,null,"Chimeras mated with wildtype C57BL/6N","No","2010-10-01","Cryopreserved sperm"]
[8658,"S25HR","B6(Cg)-Igh<tm1Rbr> Rag1<tm1Mom> Samhd1<em1Cjo>/Cjo",null,"Recessive","SAM domain and HD domain, 1","Samhd1",null,"E330031J07Rik","MGI:1927468",{"$nulls":3},"2"]
[5319,"F/F x Mal ; gp130Y757F x Mal","B6;129-Il6st<tm1Ern> Tirap<tm1.1Pjh>/MarpApb",null,"Dominant","toll-interleukin 1 receptor (TIR) domain-containing adaptor protein","Tirap","Unknown","Mal, Mal, MyD88-adapter-like, wyatt","MGI:2152213","toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; targeted mutation 1.1, Paul J Hertzog","Tirap<tm1.1Pjh>","MGI:4939795","9",{"$nulls":15},"Unknown"]
[5231,"K14gBlo","C57BL/6-Tg(K14-HSVgB)35Cbn/WehiApb",null,"Dominant",{"$nulls":25},"Herpes Simplex Virus-1 glycoprotein B","human keratin-14 (K14)","low",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",null,"at least 12","transgenic x C57BL/6","No","2010-10-06","Cryopreserved sperm"]
[5232,"Ben","C57BL/6-Tigd2<tm1>",null,"Recessive","tigger transposable element derived 2","Tigd2","Nil",null,"MGI:1915390",{"$nulls":3},"6",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-10-08","Cryopreserved sperm"]
[7600,"APN 366","C57BL/6N-A<tm1Brd> Prrt2<tm1a(KOMP)Wtsi>MarpApb",null,"Recessive","nonagouti","a",null,"agouti, agouti signal protein, As, ASP","MGI:87853","nonagouti; targeted mutation 1, Allan Bradley","A<tm1Brd>","MGI:3842513","2"]
[4883,"Fas10","NOD-Tg(RIP7-dnhFAS)10Het/Apb",null,"Dominant",{"$nulls":25},"human Fas (Fas5)","rat insulin promoter (RIP7)","High, restricted to pancreatic beta cells",{"$nulls":9},"Unknown","Mice do not develop diabetes and have a delayed onset of insulitis.","NOD/Lt","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","15",null,"NOD/Lt x Fas-10  transgenic positive","No","2009-09-28","Cryopreserved sperm"]
[5569,"HYf","B6;129-Hif1a<tm3Rsjo>/AusbApb",null,"Recessive","hypoxia inducible factor 1, alpha subunit","Hif1a","Normal","bHLHe78, HIF-1alpha, HIF1alpha, MOP1","MGI:106918","hypoxia inducible factor 1, alpha subunit; targeted mutation 3, Randall S Johnson","Hif1a<tm3Rsjo>","MGI:2386679","12",{"$nulls":28},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-08-29","Cryopreserved sperm"]
[7601,null,"SJL/ASAM<MRI116712>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Normal","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","2",null,null,"No","2014-02-24","Cryopreserved sperm"]
[5238,"IL-6 knockout ; C57.IL-6 -/-","C57BL/6-IL6<tm1Kopf>/LudApb",null,"Recessive","interleukin 6","Il6","Nil","Il-6","MGI:96559","interleukin 6; targeted mutation 1, Manfred Kopf","Il6<tm1Kopf>","MGI:1857197","5",{"$nulls":15},"No",{"$nulls":12},"Decreased pro-B cell number: the percentage of CD19+ B cell progenitors in the bone marrow is decreased from 58% to 35%.Decreased interferon-gamma secretion: after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, reduced interferon gamma production is observed.Increased interleukin-4 secretion: after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, enhanced Il-4 secretion is observed.Abnormal interleukin-6 secretion: intraperitoneal administration of LPS does not induce production of Il6 in the livers of mutants compared to wild-type where expression is increase.Increased body temperature: injection of Il1beta results in body temperature elevation by about 0.5C.Abnormal glucose homeostasis: inhibition of hepatic glucose production by ICV infusion of insulin is attenuatedinhibition of hepatic glucose production assessed by a euglycemic hyperinsulinemic clamp is also attenuated.Impaired glucose tolerance: impaired glucose tolerance on a high fat diet.Abnormal emotion/affect behavior.Behavioral despair: increased latency to \"give up\" in a forced swim test.Increased anxiety-related response: * less time spent in the illuminated areas of a light-dark box. * significantly decreased time spent in the open arms of an elevated maze. * significantly decreased number of entries into the open arms of an elevated maze.Increased fear-related response: * lower latency to escape adverse stimuli. * fewer failures to escape adverse stimuliHyperactivity:  * increased locomotor activity in open field testsabnormal sleep pattern. * injection of Il1beta results in reduced dark phase wakefulness. * injection of Il1beta results in increased non REM sleep. * increased time in non-REM sleep after sleep deprivation persists longer than for controls but increase in time is equivalent.Decreased body weight: lower body weight at 4 months of age is due largely to lower fat mass.Obese: obesity develops by 8 months of age.Increased susceptibility to induced colitis: severe erosion of the intestinal epithelium from exposure to 3.5% dextran sodium sulfate.Decreased T cell number: T cells are reduced in the periphery by 20-40%.Abnormal T cell differentiation: thymocytes are consistently reduced by 20-40%.Abnormal microglial cell morphology: modest increase in microglial density after haloperidol treatment relative to the increase seen in controls.Abnormal acute phase protein level: 100-fold reduction in SAA production by the liver in response to turpentine injection or listeria infection.Defective cytotoxic T cell cytolysis: cytolytic activity of CD8 T cells to vaccinia virus infected cells is reduced 3-10 fold.Increased susceptibility to bacterial infection: 10 to 100 fold increase in bacterial titers in the liver and spleen of mice infected with Listeria.Increased susceptibility to viral infection: viral titers are 10-1000 fold higher in the ovaries and lungs of vaccinia virus infected mice.Abnormal capillary morphology: fewer capillaries in the heartabnormal heart morphology.Abnormal heart development:  * loss of cell-cell interaction between myocytes and fibroblasts. * increased number of fibroblasts and decreased numbers of myocytes.Decreased heart weight: heart weight/body weight and heart weight/tibia length ratios both significantly reduced.Abnormal heart ventricle morphology.Abnormal interventricular septum morphology: modestly increased interstitial collagen.Dilated heart left ventricle.Thin ventricular wall:  * both anterior and posterior walls of the left ventricle are thin. * increased interstitial collagen in the free walls of both left and right ventricles.Abnormal cardiovascular system physiology: * increased cell proliferation and apoptosis in 5 day old hearts. * proliferation at 5 days primarily by non myocytes. * apoptosis at 5 days primarily of myocytes.Decreased cardiac muscle contractility: * both fractional shortening and ejection fraction are decreased in adults and at 5 and 15 days of age. * cardiac dysfunction beginning at 15 days of age. * cardiac dilation is more or less normal at 5 days of age.Abnormal learning/memory/conditioning.Abnormal object recognition memory: * increased exploration in novel object recognition tests. * reduced exploration in initial phase of novel object recognition tests.Abnormal long term object recognition memory: reduced object recognition when retested.Greater object recognition memory.Abnormal spatial learning:  * longer escape latencies in a Morris water maze. * shorter time spent in the target quadrant of a Morris water maze. * slower to relocate platform after it is moved.Abnormal brain interneuron morphology: parvalbumin positive interneurons in the hippocampus suffer less loss in numbers with age.Abnormal CNS glial cell morphology:Abnormal microglial cell morphology: modest increase in microglial density after haloperidol treatment relative to the increase seen in controls.Abnormal astrocyte morphology: density fails to increase in response to neurotoxin (6-OHDA) lesioning.Aabnormal neuron morphology:Abnormal axon morphology:  * axon terminal tree is 25% larger in the substantia nigra pars compacta than for controls. * resistant to the effects of haloperidol treatment on terminal trees. * neurotoxin lesion results in reduced terminal tree density.Abnormal nervous system physiology:Abnormal neuron physiology: age induced increase in oxygen consumption in synaptosomes is attenuated.Decreased cardiac muscle contractility: * both fractional shortening and ejection fraction are decreased in adults and at 5 and 15 days of age. * cardiac dysfunction beginning at 15 days of age. * cardiac dilation is more or less normal at 5 days of age.Abnormal muscle progenitor cell migration: migration of primary myoblasts is reduced relative to controls.Abnormal skeletal muscle fiber morphology:  * cross-sectional area of myofibers does not increase after overload of the plantaris muscle by incapacitation of the gastrocnemius, measured 14 and 42 days after overload. * no change in myonuclear numbers.Abnormal skeletal muscle satellite cell proliferation: proliferation is defective.Retinal outer nuclear layer degeneration: * higher level of apoptosis after retinal separation from the retinal pigment epithelium. * higher rate of photoreceptor cell death after 1 month.Abnormal bone healing: * callus formed after bone fracture is denser after 2 weeks than is true in controls. * tissue mineral density is less at 4 and 6 weeks after injury than for controls. * greater collagen content at 2 weeks after fracture but not at 4 or 6 weeks.Decreased bone mineral density: * mineral density of cortical bone reduced * reduced crystallinity relative to controls * reduced mineral/matrix ratio in cortical bone at both 2 and 4 weeks.Decreased incidence of chemically-induced tumors: reduced incidence of hepatocellular cancer in males treated with diethyl nitrosamine relative to incidence in control males.Hepatic necrosis: less necrosis resulting from diethyl nitrosamine treatment.Liver degeneration: * less hepatic injury in males from treatment with diethyl nitrosamine. * less apoptosis due to diethyl nitrosamine treatmentless compensatory proliferation as a result of diethyl nitrosamine treatment.Abnormal pulmonary gas exchange: elevated respiratory exchange rate in young mice.Abnormal homeostasis.Increased circulating glucose level: * elevated basal glucose levels at 8 months but not in younger mice. * glucose levels do not differ from controls in young mice after 1 hour of exercise.Abnormal oxygen consumption: oxygen consumption is not maintained at as high a level after 12 minutes of running as in controls.Abnormal acute phase protein level: 100-fold reduction in SAA production by the liver in response to turpentine injection or listeria infection.Abnormal exercise endurance: reduced treadmill endurance.Abnormal bone healing: * callus formed after bone fracture is denser after 2 weeks than is true in controls. * tissue mineral density is less at 4 and 6 weeks after injury than for controls. * greater collagen content at 2 weeks after fracture but not at 4 or 6 weeks.Abnormal involution of the mammary gland: develops more slowly.Increased susceptibility to induced colitis: severe erosion of the intestinal epithelium from exposure to 3.5% dextran sodium sulfate.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-12","Cryopreserved sperm"]
[5000,"TRAP-cre","B6.CBA-Tg(Acp5-cre)3Rda/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 3, Rachel A Davey","promoters 1B and 1C from exon 1 of Acp5",{"$nulls":10},"Transgenic mice express Cre recombinase in osteoclasts.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-02-01","Cryopreserved sperm"]
[4876,"Bc.Gal KO","BALB/c-Ggta1<tm1>/Apb",null,"Recessive","glycoprotein galactosyltransferase alpha 1, 3","Ggta1",null,"alpha Gal, alpha3GalT, Gal, GALT, Ggta, Ggta-1, glycoprotein alpha galactosyl transferase 1","MGI:95704",{"$nulls":3},"2",{"$nulls":28},"Matings between mice heterozygous for the inactivated GalT gene produced genotype ratios that deviated significantly from the predicted Mendelian 1:2:1 (wild type:heterozygote:homozygote) ratio. Cortical cataracts developed in all GalT-/- mice at 4-6 weeks of age.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","11",null,null,"No","2009-09-28","Cryopreserved sperm"]
[5672,"CD11c-DTR/GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5048,"NOD.pIgR-/- R0 N10","NOD.B6(D1Mit48-D1Mit348)N10-Pigr<tm1Rast>",null,"Recessive","polymeric immunoglobulin receptor","Pigr","Unknown",null,"MGI:103080",null,null,"MGI:2651659","1",{"$nulls":15},"No",{"$nulls":12},"Like B6.pIgR-/- mice (described in Uren et al., 2003), this mouse strain does not produce functional pIgR, and therefore lacks IgA in secretions and has increased levels of IgA in serum. The incidence of diabetes in female mice is 75-85% after 43-weeks, which is significantly higher than the incidence of diabetes in female NOD/Lt mice in our facility (50-60% at 43-weeks of age). The incidence of diabetes in male mice is 25-50% after 43 weeks of age, which is significantly higher than the incidence of diabetes in male NOD/Lt mice in our facility (5-10% at 43-weeks of age).","Like B6.pIgR+/- mice, heterozygotes of this mouse strain produce functional pIgR, and have normal levels of IgA in secretions, however the levels of IgA in serum are intermediate between NOD/Lt and NOD.pIgR-/-. The incidence of diabetes in heterozygous females is 70%, and heterozygous males is 30%. ","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm"]
[5053,"NOD.B6 R7 N12","NOD.B6(D1Mit48-D1Mit495)N12",null,"Recessive",{"$nulls":37},"The incidence of diabetes in female mice is 80% after 43-weeks, which is significantly higher than the incidence of diabetes in female NOD/Lt mice in host facility (50-60% at 43-weeks of age). The incidence of diabetes in male mice is 58% after 43 weeks of age, which is significantly higher than the incidence of diabetes in male NOD/Lt mice in host facility (5-10% at 43-weeks of age).","The incidence of diabetes has not been tested in heterozygotes of this mouse strain.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","12","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm"]
[5242,"FF:IFNAR2KO ; gp130Y757F x IFNAR2","B6;129/Sv-Il6st<tm1Ern> Ifnar2<tm1Pjh>/Apb",null,"Dominant","interleukin 6 signal transducer","Il6st","Normal","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Gastric tumoursSplenomegalyLymphadenopathy","unknown","C57BL/6 x 129/Sv ","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-10-14","Cryopreserved sperm"]
[5087,"APN25","B6.129Ola-Tcfcp2l1<Gt(AS0519)Wtsi>/MIMR",null,"Recessive","transcription factor CP2-like 1","Tcfcp2l1","Unknown","Cp2l1, Crtr-1, D930018N21Rik, LBP-9","MGI:2444691","transcription factor CP2-like 1; gene trap AS0519, Wellcome Trust Sanger Institute","Tcfcp2l1<Gt(AS0519)Wtsi>","MGI:4346711","1",{"$nulls":28},"Unknown for this mutant.Targeted mutation is postnatal lethal.",null,"C57BL/6 x 129","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-04-09","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion P3A4 Tcrb, Francis R Carbone","Tcrb"]
[3311,"Δtau ; delta Tau74","C57BL/6-Tg(Thy1.2-hTau)",null,"Recessive",{"$nulls":25},"truncated human tau 40 (projection domain) aa 1-255","murine Thy1.2",{"$nulls":11},"No obvious altered phenotype","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"T6 x C57BL/6","No","2008-06-09","Cryopreserved sperm"]
[{"$nulls":30},"Tcrb","Cbeta2","yes"]
[5093,"Iggy","SPIF-1 NEO KO",null,"Recessive","SPIF-1","SPIF-1",{"$nulls":6},"15",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-04-16","Cryopreserved sperm"]
[5249,"FGFPC","C57BL/6-Tg(FXN/EGFP)CSars/Apb","C57BL/6-Tg(FXN/EGFP)CSars/Apb","Recessive",{"$nulls":25},"Human FRATAXIN gene","FXN endogenous promoter","Normal",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","21","Hemizygous FXN-EGFP transgene X Hemizygous FXN-EGFP transgene","No","2010-10-20","Cryopreserved sperm"]
[{"$nulls":30},"human leukocyte antigen class II"]
[7316,"ENU19 WT 23b","ANU:ENU19WT:023b",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Mice have increased population of CD8+CD44 T cells","Het mice have not been assessed","C57BL/6JAnu","Yes","Unknown","Unknown","Yes","Unknown","Unknown","No","Good","0","4","affected by affacted or unaffected by affected","No","2013-04-12","Cryopreserved sperm"]
[5364,"B6.hCD4.IAE.427-3 ; triple 427","C57BL/6-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427/Apb",null,"Dominant","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No","human leukocyte antigen class II",{"$nulls":11},"HLA DR4 and DQ3 expression was evident on B cell but not T cells, dendritic cells and a proportion of macrophages.DR4-DQ3 mice develop protective immunity following infectious challenge with S. typhimurium.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21","Cryopreserved sperm"]
[5524,"Gp130dstat/dstat(Balb/C)","C;(Cg)-Il6st<tm1Ard>/LudApb",null,"Recessive","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Ashley R Dunn","Il6st<tm1Ard>","MGI:2388476","Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality: * numbers deficient at weaning * ratio of homozygotes normal at E18.Premature death (J:79555): * 6 month life span for males * 8 month life span for femalesDecreased body length: 20-30% shorter trunk length at birth.Decreased body weight: 20-30% lower body weight at birth.Abnormal uterine environment: failure of implantation, blastocysts will develop to term in wild-type recipient femalesFemale infertility: females show no external signs of pregnancy regardless of male genotype.Gastrointestinal haemorrhage: faecal blood at 4 months of age.Abnormal digestive system morphology.Rectal prolapse.Gastrointestinal ulcer:  * caecal ulcers * ulceration of the anorectal regionGgastric ulcer: ulceration of the gastric pylorus at 4 months of age.Large intestinal inflammation: caecal inflammation.Increased susceptibility to induced colitis: * severe erosion of the intestinal epithelium from exposure to 3.5% dextran sodium sulfate. * remain moribund when exposure is ended.Abnormal leukocyte cell number: white blood cell count significantly higher than in controls.Decreased immunoglobulin level.Decreased IgA level: * basal IgA levels are reduced * impaired ability to mount an intestinal IgA response after challenge * basal IgM is normalDecreased IgG level: impaired ability to mount an intestinal IgG response after challenge.Conjunctivitis.Increased susceptibility to parasitic infection: tend to carry higher parasitic loads.Abnormal common myeloid progenitor cell morphology: * colony forming cells elevated in the spleen but not in bone marrow * elevated \"CFU-S\" hematopoietic progenitor cells * hematopoietic progenitors elevated in the liver at E14 relative to controls.Abnormal megakaryocyte morphology.Abnormal thrombopoiesis: * impaired maturation of megakaryocytes to produce platelets * 40% reduction in the number of platelets produced per megakaryocyte.Decreased platelet cell number: platelet count reduced 30%.Decreased megakaryocyte cell number: by 23% in bone marrow.Increased megakaryocyte cell number: numbers in spleen increased 2 fold relative to controls.Skeleton phenotype: trabecular bone volume is normal.Abnormal femur morphology.Decreased diameter of femur: significantly reduced femoral width.Short femur.Abnormal joint morphology.Abnormal joint capsule morphology: * cartilaginous nodules in joint capsules that replace menisci and support cartilage in knee joints * erosion of articular surfaces in older mice.Joint swelling: * of weight bearing joints in 60% of adults * observed by 7 days of age * more severe in males than femalesAbnormal joint mobility: * flexion abnormalities of hindlimbs * reluctance to stand * restricted flexion and extension of ankles and wrists * stiffness of one or more limbsIncreased cell proliferation: proliferative response of fibroblasts in culture to Il6 is increased.Gastrointestinal hemorrhage: fecal blood at 4 months of age.",null,"BALB/c","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-06-14","Cryopreserved sperm"]
[7610,"DBM/J","BKS.Cg-Dock7<m> +/+ Lepr<db>/JAusb",null,"Dominant","dedicator of cytokinesis 7","Dock7",null,"3110056M06Rik, LOC242555, m, mKIAA1771","MGI:1914549","dedicator of cytokinesis 7; misty","Dock7<m>","MGI:1856946","4",{"$nulls":28},"Displays a mellitus diabetes at 3-4 weeks of age",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2014-02-28"]
[8669,"CBE1-5","C57BL/6-Cbe1<em1Marp>/MarpMob",null,"Recessive","RIKEN cDNA 1110017D15 gene","1110017D15Rik","Unknown","Cbe1, Smrp1","MGI:1920971",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-03-01","Cryopreserved sperm"]
[5573,"Par2 KO","129X1/Sv-PAR2<F2rl1<tm1Mslb>/Apb",null,"Recessive","coagulation factor II (thrombin) receptor-like 1","F2rl1","Nil","Gpcr11, PAR-2, Par2, Protease-activated receptor-2, proteinase-activated receptor-2","MGI:101910","coagulation factor II (thrombin) receptor-like 1; targeted mutation 1, Mary Stevens","F2rl1<tm1Mslb>","MGI:2389587","13",{"$nulls":28},"Normal","Normal","129Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-09-01","Cryopreserved sperm"]
[8670,"Bmi1<Cre-ER>","B6J;129-Bmi1<tm1(cre/ERT)Mrc>/JAnu",null,"Dominant","Bmi1 polycomb ring finger oncogen","Bmi1",null,"Bmi1, Bmi-1, Pcgf4","MGI:88174","Bmi1 polycomb ring finger oncogene; targeted mutation 1, Mario R Capecchi","Bmi1<tm1(cre/ERT)Mrc>","MGI:3805814","2",{"$nulls":29},"These targeted mutant mice carry tamoxifen-inducible Cre under the transcriptional control of the mouse Bmi1 (Bmi1 polycomb ring finger oncogene) promoter. When crossed with a strain containing a loxP-flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions, and when crossed with a floxed reporter strain, lineage tracing of Bmi1-expressing cells is possible. ","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-03-04","Cryopreserved sperm"]
[5384,"Stx16","C57BL/6-Stx16",null,"Dominant","Syntaxin 16","Stx16","Unknown","SYN16","MGI:1923396",{"$nulls":3},"2",{"$nulls":15},"No",{"$nulls":12},"Unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Homozygous pairs","No","2011-01-11","Cryopreserved sperm"]
[5185,"MMP13KO RAG1KO FVBn","FVB/N(Cg)-Mmp13<tm1.1Werb> Rag1<tm1>/Apb",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848",{"$nulls":3},"2",{"$nulls":15},"No"]
[5423,"203.2 ; cTnI-G203S.2","C57BL/6-Tg(Myh6-TNNI3*G203S)2Chs/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Christopher Semsarian","cardiac specific mouse αMHC promoter (alpha myosin heavy chain)","48% of endogenous",{"$nulls":9},"Unknown","Mice develop cardiac phenotype - hypertrophic cardiomyopathy. Onset age dependent upon the amount of transgene protein expressed.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",null,null,"Transgenic x non-transgenic sibs","No","2011-02-08","Cryopreserved sperm"]
[7280,"B6 gamma -/-","B6.FcERIgammaKO-/-","HOGA","Semi-dominant","FceR gamma chain","FceRIg","Nil",{"$nulls":5},"1",{"$nulls":28},"normal","normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","12",null,null,"Yes","2013-02-15","Cryopreserved sperm"]
[5473,"Gpc3 knockout","B6;Cg-Gpc3<tm1Fil>/Apb",null,"Dominant","glypican 3","Gpc3","Nil","OCI-5","MGI:104903","glypican 3; targeted mutation 1, Jorge Filmus","Gpc3<tm1Fil>","MGI:2159356","X",{"$nulls":15},"No",{"$nulls":12},"Phenotype is highly strain dependent. For example, as the proportion of C57BL/6 background increases, phenotypic effects typical of Simpson-Golabi-Behmel syndrome begin to manifest and become more severe with increasing proportion of C57BL/6 background. For females, affected tissues include, craniofacial, skeletal, renal, urinary, respiratory and reproductive systems. Animals are also larger. Postnatal lethality: phenotype is stated to be similar to that of Gpc3tm1Fil male hemizygotes; however, no data are presented in.Mandible hypoplasia.Abnormal perineum morphology: mutant females with an imperforate vagina display swelling of the perineum.Abnormal perineum morphology: mutant females with an imperforate vagina display swelling of the perineum.Dilated uterus: mutant females with an imperforate vagina have a dilated, fluid-filled uterus.Vagina atresia: mutant females exhibit an imperforate vagina at a higher frequency (30%) than wild-type females (4%).Lung inflammation.Increased susceptibility to bacterial infection.Abnormal kidney development.Abnormal ureteric bud morphology.Abnormal ureteric bud branching morphogenesis.Kidney cysts.Increased body weight.","Because Gpc3 is on the X chromosome, affected males are hemizygous and show many of the phenotypic characteristics of homozygous females.Females:Abnormal kidney development: * from N4 on, some heterozygous females display dysplastic kidneys (also noted in a large proportion of mice from earlier backcrosses) * the degree of renal dysplasia varies from mouse to mouse.Abnormal ureteric bud morphology.Abnormal ureteric bud branching morphogenesis.Kidney cysts: from N4 on, some heterozygous females display cystic kidneys (also noted in a large proportion of mice from earlier backcrosses).Increased body weight: heterozygotes display an intermediate size between hemizygous mutant males and wild-type controls at all time points.","C57BL/6 x CD-1","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","unknown",null,"Complex. Maintain on 50:50 C57BL/6 x CD-1 (or Swiss) until required to study phenotypic effects. Then, cross to C57BL/6 to \"develop\" phenotype.","No","2011-04-01","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 1, Lewis A Chodosh","MMTV LTR"]
[7320,"Rictorfl/fl","B6.129-Rictor<tm1Rueg>/Adel",null,"Dominant","RPTOR independent companion of MTOR, complex 2","Rictor",null,"921505C17Rik, 6030405M08Rik, D530039E11Rik","MGI:1926007","RPTOR independent companion of MTOR, complex 2; targeted mutation 1, Markus Ruegg","Rictor<tm1Rueg>","MGI:3829768","15",{"$nulls":28},"Normal","Unknown","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",null,null,"homozygote x homozygote","No","2013-04-18","Cryopreserved sperm"]
[5295,"EC-SOD ; B6.huSOD3.Tg (TE)","C57BL/6-Tg(H2-K<b>-SOD3)/StvApb",null,"Dominant",{"$nulls":25},"human superoxide dismutase 1, extracellular","H2-K<b>",{"$nulls":10},"These mice contain human extracellular superoxide dismutase (SOD3) modified to include a glycosyl phosphatidylinositol (GPI) membrane linkage signal & tagged with a FLAG epitope tag. SOD3 is expressed from the mouse H-2Kb (MHC Class I) promoter. The antioxidant enzyme is expressed in most nucleated cells, which should therefore be protected from (extracellular superoxide anion) oxidative injury. This has been demonstrated using pancreatic islets isolated from the transgenic mice.The mice show no overt phenotype.  Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","10",null,null,"No","2010-10-29","Cryopreserved sperm"]
[8676,"ASD1030:Bmi1:fl","STOCK Bmi1<tm1.1Sjm>/JAnu",null,"Recessive","Bmi1 polycomb ring finger oncogene","Bmi1","Unknown","Bmi1, Bmi-1, Pcgf4 ","MGI:88174 ","Bmi1 polycomb ring finger oncogene; targeted mutation 1.1, Sean J Morrison","Bmi1<tm1.1Sjm>","MGI:5638198","2",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-03-14","Cryopreserved sperm"]
[7321,"R26eYFP","B6.129-Gt(ROSA)26Sor<tm1(EYFP)Cos>/Adel",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","Unknown",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2013-04-19","Cryopreserved sperm"]
[5486,"ENU20FLT3-ITD:G1(#37)","ENU20FLT3-ITD:G1",null,"Dominant","FMS-like tyrosine kinase 3","Flt3","Increased","CD135, Flk-2, Flk2, Flt-3","MGI:95559","FMS-like tyrosine kinase 3; targeted mutation 1, D Gilliland","Flt3<tm1Dgg>","MGI:3763385","5",{"$nulls":15},"Yes",{"$nulls":12},"Accelerated onset of Acute Myeloid leukaemia.","Accelerated onset of Acute Myeloid leukaemia.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"G1",null,"No","2011-04-19","Cryopreserved sperm"]
[7322,"Pdx1-cre","B6(Cg)-Tg(Ipf1-cre)1Tuv/AusbAnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 6, David A Tuveson","Ipf1","Islet cells of pancreas",{"$nulls":9},"Normal.Islet cells express Cre recombinase","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-04-20","Cryopreserved sperm"]
[7347,"CSTCR","BALB/c-Tg(TcraTcrb)1Zav",null,"Dominant",{"$nulls":25},"T cell receptor alpha, T cell receptor beta",{"$nulls":12},"The mice express a monoclonal TCR specific for SYVPSAEQI in context of H2-K<d>","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-06-04"]
[5942,"NfibCond/Emx1Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7323,"ENU19:B6:Trim7","C57BL/6-Trim7<m1Anu>/AnuApb","C57BL/6-Trim7<m1Anu>/AnuApb","Recessive","tripartite motif-containing 7","Trim7",null,null,"MGI:2137353","mutation 1, The Australian National University","Trim7<m1Anu>",null,"11","ENSMUSG00000040350","ENSMUST00000109213","Trim7-001","124","370","A to G","ENSMUSE00000679460","2","44","Asparagine to Aspartic acid",{"$nulls":4},"TGCTGTCCCGGGAAGTGACACAGAAACAGAATGAGAACCTGGCCCAGCTGGAGGGTGAGAT",{"$nulls":13},"Unknown",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-04-22","Cryopreserved sperm"]
[7324,"PW1-LacZ","C57BL/6-Tg(Peg3-LacZ)/MarpApb",null,"Semi-dominant",{"$nulls":25},"LacZ","paternally expressed gene 3 (PW1/Peg3) ",{"$nulls":10},"Unknown","Normal.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-04-23","Cryopreserved sperm"]
[7349,"Bmp2 - BAC clone RP23-85011 ; 5' Bac","B6.DBA-Tg(Bmp2)/VccriApb",null,"Dominant",{"$nulls":25},"Bac Bmp2",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-06-06","Cryopreserved sperm"]
[6897,"APN188","C57Bl/6NTac-Notch4<tm1(KOMP)Vlcg>/Marp",null,"Recessive","Notch gene homolog 4 (Drosophila","Notch4","Unknown","Int3, Int-3, N4","MGI:107471 ","Notch gene homolog 4 (Drosophila); targeted mutation 1, Velocigene ","Notch4<tm1(KOMP)Vlcg> ","MGI:4842905 ","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-17","Cryopreserved sperm"]
[5943,"NfixCond",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6898,"APN212","C57Bl/6N-Crisp2<tm1a(KOMP)Mbp>/MarpApb",null,"Recessive","cysteine-rich secretory protein 2","Crisp2","Unknown","CRISP-2, GAPDL5, Tpx1, Tpx-1 ","MGI:98815 ","cysteine-rich secretory protein 2; targeted mutation 1a, Mouse Biology Program, UCDavis","Crisp2<tm1a(KOMP)Mbp> ","MGI:4888856","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-05-17","Cryopreserved sperm"]
[7115,null,"ENU11B6053b",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to infection with ECTV","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-10-29","Cryopreserved sperm"]
[7533,"ENU24:014:Trps1","C57BL/6NCrlAnu-Trps1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Trps1<m1Anu>/AnuApb","Recessive","trichorhinophalangeal syndrome I (human)","Trps1",null,"D15Ertd586e","MGI:1927616","trichorhinophalangeal syndrome I (human); mutation 1, The Australian National University","Trps1<m1Anu>","MGI:5563401","15","ENSMUSG00000038679","ENSMUST00000165201","Trps1-001","3436","3526","A to T","ENSMUSE00000478584","6","1146","Threonine to Serine",{"$nulls":4},"ATCCTTGCCAAAACTATGTGCCTTATCCCACCTTCAATCTGCCTCCTCATTTCTCAGCTGT",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G2N1",null,"No","2013-12-06","Cryopreserved sperm"]
[8683,null,"C57BL/6NCrlAnu-Ikbkb<em2Anu>/1AnuApb",null,"Recessive","inhibitor of kappaB kinase beta","Ikbkb",null,"IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta","MGI:1338071",{"$nulls":3},"8",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-03","Cryopreserved sperm"]
[7118,"CD11c-Cre","B6.Cg-Tg(Itgax-cre)1-1Reiz/JMarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 1-1, Boris Reizis","Itgax, integrin alpha X, CD11c",{"$nulls":10},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-10-29","Cryopreserved sperm"]
[5747,"Eddie",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5752,"Emx1-EGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5753,"Emx1/gad67",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7100,"Osx-Cre Rb","B6(Cg)-Rb1<tm3Tyj> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Normal","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":16},"transgene insertion 1, Andrew P McMahon","Osterix (Sp7)","good in osteoblast precursors",{"$nulls":9},"No obvious phenotype. No effect on lifespan, breeding or skeleton","None observed. Osx-Cre mice have phenotypes due to teh Osx-Cre - malocclusion, slightly smaller than a truw wild-type. No other effect of loss of Rb","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5","unknown/not collected","Osx-Cre+ve pRBfl/+ male to Osx-Cre-ve pRBfl/+ female","No","2012-10-04","Cryopreserved sperm"]
[7329,"ENU19 WT:029:a:B6:F3","C57BL/6JAnu-Gucd1<m1Anu>/Anu",null,"Recessive","guanylyl cyclase domain containing 1","Gucd1","Unknown","1110038D17Rik","MGI:1916028","mutation 1, The Australian National University","Gucd1<m1Anu>",null,"10","ENSMUSG00000033416",null,null,"536","721","G to C","ENSMUSE00000226356","5","179","Arginine to Proline",{"$nulls":4},"TACTCCCAGTGGCCACCGCTGCTTCTGCCGCACCCCCGACTACCAAGGCCACTTCATCGTC","Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-05-01","Cryopreserved sperm"]
[7250,"ENU18China:68b","C57BL/6JAnu-Ptpn6<m2Anu>/AnuApb","C57BL/6JAnu-Ptpn6<m2Anu>/AnuApb","Dominant","protein tyrosine phosphatase, non-receptor type 6","Ptpn6 ","Reduced","hcp, Hcph, Ptp1C, SHP-1, Spin","MGI:96055","protein tyrosine phosphatase, non-receptor type 6; mutation 2, The Australian National University","Ptpn6<m2Anu>","MGI:5563434","6","ENSMUSG00000004266","ENSMUST00000112484","Ptpn6-002","4","205","C to T","ENSMUSE00000691827","1","2","Valine to Methionine",{"$nulls":4},"ATGGTGAGGTGGTTTCACCGGGACCTCAGCGGGCC",{"$nulls":13},"Reduced IgM expression on mature B cells. Reduced percentage of mature B cells. Adult homozygous mice are healthy.","Mild reduction in the percent of mature B cells and mild reduction of IgM on mature B cells","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7","homozygous x homozygous","No","2012-12-13","Cryopreserved sperm"]
[7371,"ENU26:044:G6pc:B6:G2","C57BL/6NCrlAnu-G6pc<m1Anu>/Anu",null,"Recessive","glucose-6-phosphatase, catalytic","G6pc","Unknown","G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha","MGI:95607","mutation 1, The Australian National University","G6pc<m1Anu>",null,"11","ENSMUSG00000078650","ENSMUST00000019469","G6pc-001","248","484","G to T","ENSMUSE00000113003","2","83","Arginine to Leucine",{"$nulls":4},"CGTCTTCAAGTGGATTCTGTTTGGACAACGCCCGTATTGGTGGGTCCTGGACACCGACTAC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-05","Cryopreserved sperm"]
[7131,"SIRT5^","129-Sirt5<tm1Fwa>/JAusb",null,"Recessive",null,"Sirt5",null,null,"MGI:3769236",{"$nulls":3},"Unknown",{"$nulls":28},"Not Known",null,"129","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7140,"Manni","B6.129S1-Ill2b<tm1Jm>/Ausb",{"$nulls":3},"IL12p40",null,null,"MGI:1857201",{"$nulls":34},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7153,"IKK2FL","C57BL/6-Ikbkb<tm2Cgn>/Ausb/Ausb",{"$nulls":3},"IKK2",null,null,"MGI:2652651",{"$nulls":34},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7151,"KrasG12D","B6.129-Kras<tm4Tyj>/Ausb",null,"Recessive",null,"Kras",null,null,"MGI:2429948",{"$nulls":34},"B6/129","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[8689,"Cish wt/wt","BALB/c-Cish<wt>/",null,"Dominant","cytokine inducible SH2-containing protein","Cish",null,"Cis, CIS1, cytokine-inducible SH2 protein, F23","MGI:103159",{"$nulls":3},"9",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11"]
[7167,"GFP-LC3","B6.B6D2-Tg(CAG-RGFP/LC3)53Nmz/NmzRbrc/Ausb",{"$nulls":3},"LC3gFP",null,null,"MGI:3759813",{"$nulls":34},"C57BL/6JJcl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7178,"C57BLKaLwRij","C57BL/KaLwRij/AnuApb",null,"Recessive",{"$nulls":37},"May have reduced litter size.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-11-02","Cryopreserved sperm"]
[7172,"MaFIA","C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/JAusb",null,"Dominant",null,"MaFIA",null,null,"MGI:3051865",{"$nulls":3},"Unknown",{"$nulls":28},"GFP positive macrophages",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7171,"iAkt-F3","iAkt-Founder3/Ausb",{"$nulls":3},"iAKT",{"$nulls":37},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7693,"Tpbpa-Cre","C57BL/6-Tg(Tpbpa-cre,-EGFP)5Jcc",null,"Dominant",{"$nulls":25},"transgene insertion 5, James C Cross","trophoblast specific protein alpha",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2014-05-26","Cryopreserved sperm"]
[7186,"Spns2","C57BL/6DnkSpns2<tm1a(KOMP)Wtsi> (?)/Ausb",{"$nulls":3},"Spns2",null,null,"MGI:2384936 ",{"$nulls":32},"Absent pinna reflex,abnormal corneal vascularisation,abnormal braistem auditory evoked potencial,decrease leukocyte cell number,altered peripheral blood lymphocytes LSRII,decreased circulating glucose level,abnormal eye pigmenttation,increase bone mineral",null,"BL/6NTac/Den,BL/6J-TTyrcBrd;BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7187,"R-FLPo","unknown/Ausb",null,"Dominant",{"$nulls":39},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[5944,"NfixCond/Emx1Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7201,"Cx3cr1-GFP","B6.129-Cx3cr1<tm1Litt>/JAusb",null,"Dominant","chemokine (C-X3-C) receptor 1","Cx3cr1","Nil",null,"MGI:1333815","chemokine (C-X3-C) receptor 1; targeted mutation 1, Dan R Littman","Cx3cr1<tm1Litt>","MGI:2670351","9",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-11-05"]
[5583,"129X1/SUJ x Epha4KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5585,"202 KO B57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[2328,"C57BL6.gZAB-/-OT-1 ; Shastri","B6.129S2-Gzmb<tm1Ley> Gzma<tm1Simn> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","granzyme B","Gzmb","Nil","CCP-1/C11, CCP1, Ctla-1, Ctla1, GZB","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14"]
[7072,"ABCA1ABCG1 Betacell KO","Ins2Cre ABCA1fl/flABCG1fl/fl",null,"Recessive","ABCA1","ABCA1",{"$nulls":6},"9",{"$nulls":16},"Ins2Cre","Rat insulin promoter",{"$nulls":10},"Pancreatic beta islet cells do not express ABCA1 and ABCG1. Impaired glucose tolerance","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-09-03","Cryopreserved sperm"]
[7212,"APN329","C57Bl/6NSrsf3<tm1a(KOMP)Mbp>/Marp",null,"Recessive","serine/arginine-rich splicing factor 3","Srsf3","Unknown","Sfrs3, X16","MGI:98285","serine/arginine-rich splicing factor 3; targeted mutation 1a, Mouse Biology Program, UCDavis","Srsf3tm1a(KOMP)Mbp","MGI:4462527","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-15","Cryopreserved sperm"]
[7034,null,"ENU22 Bcl2:015",null,"Dominant","unknown","unknown",{"$nulls":6},"Unknown",{"$nulls":28},"High Platelet phenotype. Phenotyping technique by Advia. Not: Even though sperm freezing shows medium to low concentration and motility these mice breed extremely well.","Normal.Not: Even though sperm freezing shows medium to low concentration and motility these mice breed extremely well.","C57BL/6NCrl","Unknown","Unknown","Unknown","Unknown","Yes","Yes","No","Excellent","Mice will be frozen at G4",null,"Affected by B6","No","2012-07-31","Cryopreserved sperm"]
[7043,"Trpm5-, Trpm5 KO","C57BL/6-Trpm5<Sdmk>",null,"Dominant","transient receptor potential cation channel, subfamily M, member 5","Trpm5","Nil","9430099A16Rik, Ltrpc5, Mtr1","MGI:1861718","transient receptor potential cation channel, subfamily M, member 5; targeted mutation 1, Sami Damak","Trpm5<tm1Sdmk>","MGI:3612408","7",{"$nulls":28},"Abnormal bitter taste sensitivity (J:103852)chorda tympani nerve responses to bitter compounds similar to response to sweet compounds.Abnormal salty taste sensitivity (J:103852)chorda tympani nerve responses to salt similar to response to sweet compounds.Abnormal sour taste sensitivity (J:103852)chorda tympani nerve responses to acid compounds similar to response to sweet compounds.Abnormal sweet taste sensitivity (J:103852)chorda tympani nerve response to sweet compounds applied to the anterior taste field of the tongue is greatly reduced but not eliminatedno enhancement of response to sweet compounds by increased temperature.Abnormal umami taste sensitivity (J:103852, J:104626)chorda tympani nerve responses to monosodium glutamate similar to response to sweet compounds (J:103852).residual responses to 100 and 300 mM monosodium glutamate in a two bottle preference test (J:104626).","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-08-06"]
[7094,"RNAi-14","C57Bl/6J-HDAC3<RNAi>/MarpApb",null,"X-linked","histone deacetylase 3","Hdac3","Unknown",null,"MGI:1343091",{"$nulls":3},"X",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-09-27","Cryopreserved sperm"]
[7037,"zeta-SV129 390","129Sv-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","129Sv/B6","Yes","No","Yes","Yes","No","Yes","Yes","Good","N/A",null,"het x het","No","2012-08-06","Cryopreserved sperm"]
[7029,"APN257","C57BL/6N-Ift140<tm1a(KOMP)Wtsi>/Marp",null,"Recessive","intraflagellar transport 140 homolog (Chlamydomonas)","Ift140 ","Unknown","mKIAA0590, Tce5, Wdtc2 ","MGI:2146906 ","intraflagellar transport 140 homolog (Chlamydomonas); targeted mutation 1a, Wellcome Trust Sanger Institute ","Ift140tm1a(KOMP)Wtsi","MGI:4363217","17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N ","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-07-26","Cryopreserved sperm"]
[4807,"Jayne","ENU8BAT:023",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm"]
[5589,"a-actin-cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[8699,"INHBB","C57BL/6-Inhbb<em1Mkob>/Marp",null,"Recessive","inhibin beta-B","Inhbb",null,"activin beta-B","MGI:96571",{"$nulls":3},"1",{"$nulls":28},"Sub-fertile","Normal","C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm"]
[5590,"A107CYPOE",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells"]
[5239,"Lyn knockout Viable Motheaten mice ; C57.Lyn-/- Me v/+","C57BL/6-Lyn<tm1Ard> Ptpn6<me-v>/Apb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Nil","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"No",{"$nulls":12},"B6-Lyn<-/-> Ptpn6<me-v/+> mice develop exaggerated autoimmune disease compared with Lyn<-/-> miceAbnormal mature B cell morphology: mature B cells have about 4-fold lower surface IgM levels.","Double heterozygotes develop autoimmunity with earlier onset than single heterozygote mice","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","20 for Lyn<-/->",null,"B6-Lyn<-/-> Ptpn6<me-v/+> x B6-Lyn<-/-> Ptpn6<me-v/+>","No","2010-10-12","Cryopreserved sperm"]
[4912,"Wombi ; ENU9CAT:006","B6;CBA(Cg)-Pou1f1<wombi>/Apb",null,"Recessive","POU domain, class 1, transcription factor 1","Pou1f1","Unknown","GHF-1, Hmp1, Pit-1, Pit1, Pit1-rs1, Snell dwarf","MGI:97588","wombi","Pou1f1<wombi>",null,"16","ENSMUSG00000004842","ENSMUST00000116588","Pou1f1-202","470","585","T to A","ENSMUSE00000131906","4","156","Leucine to Glutamine",{"$nulls":4},"ATACACCCAGACAAACGTGGGCGAAGCGCTGGCTGCTGTCCACGGCTCAGAATTCAGTCAA","No",{"$nulls":12},"Male infertility. Dwarf, affected mice are smaller than littermates.Mutant found in HEL:TCR ENU library. HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","No","Yes","No","Poor",null,null,"Het x Het","No","2009-10-16","Cryopreserved sperm"]
[4911,"Per-gAB","C57BL/6-Gzma<tm1Simn> Gzmb<tm1Ley> Prf1<tm1Sdz>/AnuApb",null,"Recessive","granzyme B","Gzmb","Unknown","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14"]
[8703,"ASD752:Ssbp4","C57BL/6NCrlAnu-Ssbp4<em1Anu>/Anu",null,"Recessive","single stranded DNA binding protein 4","Ssbp4",null,"1210002E11Rik","MGI:1924150",{"$nulls":3},"8",{"$nulls":28},"Unknown","unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-16","Cryopreserved sperm"]
[5236,"Viable Motheaten mice ; C57.Me v/+","C57BL/6J-Ptpn6<me-v>/LudApb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 6","Ptpn6","Unknown","hcp, Hcph, Ptp1C, SHP-1, Spin","MGI:96055","protein tyrosine phosphatase, non-receptor type 6; viable motheaten","Ptpn6<me-v>","MGI:1856074","6",{"$nulls":15},"Yes",{"$nulls":12},"Decreased B cell number: lambda1 and lambda2, 3 B cells are reduced 14- and 4-fold, respectively, in the spleen and 5.9- and 2.2-fold, respectively, in the bone marrow compared to B cell numbers in wild-type mice.Decreased mature B cell number: a result of a rapid expansion of the plasma cell population.Increased plasma cell number: due to a factor in serum of mutant mice that increases cell maturation by three orders of magnitude.Abnormal immunoglobulin level: uncontrolled levelsAbnormal inflammatory response:  * resembles rheumatoid arthritis. * immunosuppressant drugs inhibit arthritic symptoms, but non-steroid anti-inflammatory drugs do notRheumatoid arthritis.Chronic inflammation: * reactions in the paws consist mainly of polymorphonuclear and mononuclear cell infiltration in the subcutaneous tissue extending to the periosteum and joint * paws become deformed causing progressive problems walkingInterstitial pneumonia: pneumonitis progression is slower than in Ptpn6<me> homozygotes but still causes death.Premature death: * mice die at about 9 weeks instead of at 3 weeks as in Ptpn6<me> homozygotes * death is due to a progressive and fatal autoimmune syndromeAbsent skin pigmentation: at 3-4 days of age mice have focal depigmentation of the skin.Focal hair loss: patchy absence of hair follows focal skin depigmentation giving the coat an uneven or motheaten appearance.Spontaneous skin ulceration: necrotic lesions can develop on paws, tail and ears.Abnormal skin condition.Interstitial pneumonia: pneumonitis progression is slower than in Ptpn6<me> homozygotes but still causes death.Decreased body size.Homozygous Motheaten viable mice develop early onset systemic autoimmune and inflammatory disease.  The lungs of the mice become consolidated with neutrophils and activated chitinase-laden macrophages.  The mice do not thrive, are runted and their skin, paws and ears shows signs of inflammatory disease, which is observable at weaning.  The mice are usually euthanized before 8 wks of age.","Heterozygous mice develop low level antinuclear antibodies at about 12 months of age.","C57BL/6J","Yes","No","Yes","Yes","No","Yes","No","Unknown",null,null,"Het x Het","No","2010-10-11","Cryopreserved sperm"]
[5292,"SHIP(Flox47).C57","B6.Cg-Inpp5d<tm1Rav>/LudApb",null,"Semi-dominant","inositol polyphosphate-5-phosphatase D","Inpp5d","Normal","s-SHIP, SHIP, SHIP-1, SHIP1, Src homology 2 domain-containing inositol-5-phosphatase","MGI:107357","inositol polyphosphate-5-phosphatase D; targeted mutation 1, Jeffrey V Ravetch","Inpp5d<tm1Rav>","MGI:3715982","1",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","7",null,null,"No","2010-10-29","Cryopreserved sperm"]
[5501,"A33crePR2 ","C57BL/6-Gpa33<tm1(cre)Ern>/LudApb",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,"A33 antigen","MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 1, Matthias Ernst","Gpa33<tm1(cre)Ern>",null,"1",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Cre recombinase expressed in the intestinal epithelium.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-05-09","Cryopreserved sperm"]
[5415,"APC(580s).C57","C57BL/6-Apc<tm1Tno>/LudApb",null,"Dominant","adenomatosis polyposis coli","Apc","Reduced","CC1, Min","MGI:88039","adenomatosis polyposis coli; targeted mutation 1, Tetsuo Noda","Apc<tm1Tno>","MGI:1857966","18",{"$nulls":15},"Yes",{"$nulls":12},"Exposure to liver specific carcinogen diethynitrosamine results in higher tumour incidence than het mice including hepatocellular carcinoma.Colorectal adenomas observed when exon 14 was deleted by colorectal infection of an adenovirus exressing Cre recombinase.","Low incidence of hepatocellular carcinoma.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-02-04","Cryopreserved sperm"]
[5502,"580S/TVA/Lacz  ; Apc 580S/580S;tgNA33 TVA; Tgn(lacZ13)","STOCK Apc<tm1Tno> Tg(Gpa33-TVA)#Ern Tg(Pgk1-lacZ)13Vmel/LudApb",null,"Dominant","adenomatosis polyposis coli","Apc","Reduced","CC1, Min","MGI:88039","adenomatosis polyposis coli; targeted mutation 1, Tetsuo Noda","Apc<tm1Tno>","MGI:1857966","18",{"$nulls":15},"Yes","transgenic insertion 1, Matthias Ernst","glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-05-09","Cryopreserved sperm"]
[6923,"ERT2/Pten/Gp130F (Black); A33(CreERT2)/Pten loxP/Gp130y757F (ME-276)","STOCK Gpa33<tm1(cre)Ern> Il6st<tm1Ern> Pten<tm2Mak>/Lud",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,"A33 antigen","MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 1, Matthias Ernst","Gpa33<tm1(cre)Ern>",null,"1",{"$nulls":28},"Unknown","Unknown","Mixed 129 and C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2012-06-27"]
[5270,"Crouzon","STOCK Fgfr2<tm4Lni>/Apb","MGI:3053095","Dominant","fibroblast growth factor receptor 2","Fgfr2","Normal","Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs","MGI:95523","fibroblast growth factor receptor 2; targeted mutation 4, Peter Lonai","Fgfr2<tm4Lni>","MGI:3053095","7",{"$nulls":15},"No",{"$nulls":12},"Homozygous mutants display multiple joint fusions,cleft palate, and trachea and lung defects, and die shortly afterbirth.","Fgfr2cC342Y/+ heterozygote miceare viable and fertile with shortened face, protruding eyes, prematurefusion of cranial sutures, and enhanced Spp1 expression inthe calvaria. Prone to malocclusion.","C57BL/6 (not congenic)","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2010-10-25","Cryopreserved sperm"]
[7054,"Flp/E2acre","B6.Cg-Tg(ACTFLPe)9205Dym Tg((EIIa-cre)C5379Lmgd/LudApb",null,"Dominant",{"$nulls":25},"transgene insertion 9205, Susan Dymecki","human ACTB promoter","spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-08-21","Cryopreserved sperm"]
[6794,"S164","SJL/J-tg(TCR1640)/Ausb",null,"Recessive",{"$nulls":39},"SJL/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-01-19"]
[8700,"SCRN1KO","C57BL/6J-Scrn1<em1Mkob>/MkobMarp",null,"Recessive","secernin 1","Scrn1",null,"2810019K23Rik, 6330535A03Rik, mKIAA0193, SES1","MGI:1917188",{"$nulls":3},"6",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm"]
[5576,"∆SRI ","B6.129T2-Atm<tm1Mfl>/QimrApb",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Reduced","C030026E19RIK","MGI:107202","ataxia telangiectasia mutated homolog (human); targeted mutation 1, Martin F Lavin","Atm<tm1Mfl>","MGI:2181756","9",{"$nulls":28},"Premature death: 50% mortality by 40 weeks of age Decreased body size: smaller size persists through adulthood Postnatal growth retardation: 20% growth reduction in males and 18% reduction in females from birth to 45 days of age. Increased tumor incidence: mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas Thymic lymphoma: found in all mice dying before 40 weeks, diverse cell types involved, spongy tumors with a high proportion of cells undergoing apoptosis Abnormal immune system cell morphology: occasional increase in thymocyte size. Abnormal T lymphocyte development: lymph node T cells are primarily at early stages of development. Increased double-negative T cell count: occurs at random Abnormal effector T cell morphology/development: randomly observed increases in single positive T cells. Decreased thymocyte number: 10% reduction in thymocytes, 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3. Abnormal immune system organ morphology: enlarged spleen: usually found in mice dying after 40 weeks of age. small spleen: in mice under 40 weeks of age small thymus small lymph nodes Abnormal chromosome morphology: 3 fold increase in radiation induced chromosomal aberrations. Increased cellular sensitivity to ionizing radiation: increased sensitivity of thymocytes and splenocytes to ionizing radiation. Seminiferous tubule degeneration: tubules disrupted Abnormal testis development: poorly developed Abnormal gametogenesis: abnormal oogenesis: disrupted, lack of maturing follicles and oocytes. Abnormal spermatogenesis: disrupted spermatogenesis, degenerating spermatocytes, loss of spermatids Nervous system phenotype: no gross neuronal degeneration at time points between 2 and 16 months of age. Abnormal Purkinje cell morphology: survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day, survival of cultured cells improves if cultured with cerebellar astroglial cells, develop simpler dendritic arboritization with reduced secondary branching, nitroxide free radicals improve survival and arborization Seminiferous tubule degeneration: tubules disrupted","Increased tumor incidence: average age at onset 18.6 months, varying tumor types including dermatoid cysts adenoma: 13% of total leukemia: 5% of total lymphoma:24% of total ovary tumor: 8% of total sarcoma: 32% of total, half of sarcomas are in Mammary glands","C57BL/6J x 129T2/Sv","Yes","No","Yes","Yes","Yes","Yes","Yes","Good","35","35","Hetrezygotes x Heterozygotes","Yes","2011-09-05","Cryopreserved sperm"]
[7337,"Il7tg","B6.Cg-Tg(H2-Ea-Il7)10Rhdr/ScrAusbAnuApb",null,"Recessive",{"$nulls":25},"transgene insertion 10, Rhodri Ceredig","H2-Ea promoter",{"$nulls":10},"Normal",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-05-17","Cryopreserved sperm"]
[5597,"AGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[8704,"TcrP14","B6.SJL-Ptprc<a/b> Tg(TcrLCMV)327Sdz/AnuApb",null,"Dominant","protein tyrosine phosphatase, receptor type, C","Ptprc","Normal","B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":16},"transgene insertion 327, Birgit Ledermann",null,"10 copies",{"$nulls":10},"MIce express a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for LCMV (lymphocytic choriomeningitis virus), H2-Db.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-26","Cryopreserved sperm"]
[5186,null,"ENU18WT:005b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm"]
[6768,null,"ENU12B6:C3H:020:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Ataxia",null,"C57BL/6 x C3H","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-20","Cryopreserved sperm"]
[5363,"MF-07 ; APC (580s)/ROSA26","B6;129/Sv-Apc<tm1Tno> Gt(ROSA)26Sor<tm1Sor>/Lud",null,"Recessive","adenomatosis polyposis coli","Apc","Reduced","CC1, Min","MGI:88039","adenomatosis polyposis coli; targeted mutation 1, Tetsuo Noda","Apc<tm1Tno>","MGI:1857966","18",{"$nulls":15},"Yes","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano",{"$nulls":11},"to come","to come","to come","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-12-21","Cryopreserved sperm"]
[6616,"APN 113","CPT1a",null,"Recessive","carnitine palmitoyltransferase 1a, liver ","Cpt1a",null,"Cpt1, CPTI, L-CPT I ","MGI:1098296 ",{"$nulls":3},"19","Cpt1a","ENSMUST00000025835","Cpt1a-201",{"$nulls":25},"Unknown","Normal","C57BL/6J","Unknown","Unknown","No","Unknown","Unknown","Unknown","No","Excellent",{"$nulls":3},"No","2011-10-13","Cryopreserved sperm"]
[7226,"G16-5","Gast16-5",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"A failure to thrive.The mutant homozygous embryos die before 8.5 dpc.","Normal","FVB","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","Three",null,null,"No","2012-11-20","Cryopreserved sperm"]
[{"$nulls":30},"human leukocyte antigen class II"]
[7228,"Mx-Cre pRb TNFa-/-","C57BL/6-Rb1<tm3Tyj> Tnf<tm1Gkl> Tg(Mx1-cre)1Cgn/SviApb",null,"Dominant","retinoblastoma 1","Rb1 ","Nil","pRb, Rb, Rb-1 ","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks ","Rb1<tm3Tyj>","MGI:2450162","14"]
[7233,"APN318","C57Bl/6N-A<tm1Brd> Sppl2a<tm1a(EUCOMM)Hmgu/Marp>",null,"Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802","signal peptide peptidase like 2A; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH/Marp","Sppl2atm1a(EUCOMM)Hmgu/Marp","MGI:4887673","2",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-11-28","Cryopreserved sperm"]
[5602,"Alpha 4 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[7232,"PbT-I-9 ; C57BL/6-Tg(TCRaB4-46TcrbB4-46)9Cbn","C57BL/6-Tg(H2-K<b>-Tcra,-Tcrb)9Cbn/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 9, Francis Carbone","H-2Kb",{"$nulls":10},"Majority of CD8 T cells express the transgenic T cell recepter Va8Vb10 specific for Plasmodium berghei (Pb) parasites.","As for homozygous","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,"7","brother-sister or Tg positive to C57BL/6","No","2012-11-28","Cryopreserved sperm"]
[8706,"Pedro:PR36 SJ","C57BL/6-Prdm1<em1Anu>/AnuApb",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1","MGI:99655",{"$nulls":3},"10",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-05-03","Cryopreserved sperm"]
[5414,null,"NOD.Mog7ag",null,"Recessive",{"$nulls":36},"7","Unknown",null,"NOD/Lt","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown","10",null,"Hom x Hom","No","2011-02-03","Embryo"]
[7240,"ADAR1 E861A","C57BL/6-Adar<tm1.1Xen>/SviApb",null,"Dominant","adenosine deaminase, RNA-specific","Adar ","Unknown","ADAR1, mZaADAR","MGI:1889575 ","adenosine deaminase, RNA-specific; targeted mutation 2184, TaconicArtemis","Adar1<tm1.1Xen>","MGI:5805648","3",{"$nulls":28},"Homozygous lethal at ~E12.5","heterozygous animals are normal and fertile with no apparent abnormalities","C57BL/6","No","Yes","Yes","No","Yes","Yes","No","Good","on pure C57BL/6 - was derived on C57 ES line",null,"ki/+ crossed to ki/+","No","2012-12-03","Cryopreserved sperm"]
[8708,"Katnal2 KO x Katna1 Flox","C57BL/6N-Katna1<tm1c(KOMP)Wtsi> Katnal2<tm1a(EUCOMM)>/MarpApb",null,"Recessive","katanin p60 subunit A-like 2","Katnal2",null,"3110023G01Rik, 4933439B08Rik","MGI:1924234","katanin p60 subunit A-like 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Katnal2<tm1a(EUCOMM)Wtsi>","MGI:4842422","18"]
[4452,"BALB/c.B6 TLR-4tm1 ; Billy Whiz","BALB/c-Tlr4<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 4","Tlr4","Nil","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; targeted mutation 1, Shizuo Akira","Tlr4<tm1Aki>","MGI:1860885","4",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-02-20","Cryopreserved sperm"]
[7556,"ENU26:042:SOAT1:B6","C57BL/6NCrlAnu-Soat1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Soat1<m1Anu>/AnuApb","Recessive","sterol O-acyltransferase 1","Soat1","Unknown","8430426K15Rik, Acact, ACAT-1, hid","MGI:104665","sterol O-acyltransferase 1; mutation 1, The Australian National University","Soat1<m1Anu>","MGI:5563410","1","ENSMUSG00000026600","ENSMUST00000051396","Soat1-201","1241","1452","A to C","ENSMUSE00000160863","13","414","Valine to Glycine",{"$nulls":4},"CAACTACTACAGGACCTGGAACGTGGTGGTGCACGACTGGCTCTACTACTATGTTTACAAA",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2013-12-19","Cryopreserved sperm"]
[7464,"ENU30:G1","ANU:ENU30:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2013-10-29","Cryopreserved sperm"]
[7342,"MommeD44","FVB/NJ-Nrf1<MommeD44> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","nuclear respiratory factor 1","Nrf1","Normal","D6Ertd415e","MGI:1332235","nuclear respiratory factor 1; modifiers of murine metastable epiallele D44","Nrf1<MommeD44>",null,"6","ENSMUSG00000058440","ENSMUST00000115212","Nrf1-001",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~9.5dpc)","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm"]
[5571,"Zic5 V504G: C57BL/6","B6.C(C3H)-Zic5<V504G>/HAnu","B6.C(C3H)-Zic5<m1H>/HAnu","Recessive","Zinc finger protein of the cerebellum 5","Zic5","Unknown","odd-paired related, Opr","MGI:1929518",{"$nulls":3},"14",{"$nulls":15},"Yes",{"$nulls":12},"Viable and fertile","Viable and fertile","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","0","Heterozygote animal paired with C57BL/6 animal","No","2011-08-31","Cryopreserved sperm"]
[4977,"ENU11B6:024b ; Servalan","C57BL/6JAnu-Ebf1<serv>/3AnuApb","C57BL/6JAnu-Ebf1<serv>/3AnuApb","Recessive","early B-cell factor 1","Ebf1","Unknown","O/E-1, Olf-1, Olf1","MGI:95275","early B-cell factor 1; Servalan","Ebf1<Serv>","MGI:5007783","11","ENSMUSG00000057098","ENSMUST00000081265","Ebf1-001",{"$nulls":12},"No",{"$nulls":12},"Small decrease in peripheral blood B cell numbers.Slight decrease in spleen B cell numbers","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm"]
[5604,"Ancient 3",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5609,"ASC-/-",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5575,"Setx; Setx on C57/BL6Jx129Sv background","B6;129-Setx<tm1Mla>/QimrApb","15","Recessive","senataxin","Setx","Nil","AOA2; Als4; Sen1; SCAR1; AW060766; mKIAA0625; A130090N03; A930037J23Rik.","MGI:2443480 ",{"$nulls":3},"2",{"$nulls":28},"Black or bown coat, Normal size, normal body, weight, normal life span. Male sterility","Normal","C57BL/6J x 129Sv","Yes","No","Yes","Yes","No","Yes","Yes","Good",null,"30","Hetrezygotes x Heterozygotes","No","2011-09-01","Cryopreserved sperm"]
[8267,"ENU36:006:Acss1","C57BL/6NCrlAnu-Acss1<m1Anu>/AnuApb",null,"Recessive","acyl-CoA synthetase short-chain family member 1","Acss1",null,"1110032O15Rik, Acas2, Acas2l, AceCS2","MGI:1915988",{"$nulls":3},"2","ENSMUSG00000027452","ENSMUST00000028944.3","Acss1-201","908","969","C to T","ENSMUSE00001270508","5","303","Glycine to Aspartic acid",{"$nulls":4},"ACCCAAGGGACTCGTTCATACACAGGCAGGCTATCTACTGTATGCCGCCATGACGCACAAG",{"$nulls":13},"Homozygous mice have increased CD44 MFI on T cells in the blood",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-06-07","Cryopreserved sperm"]
[7568,"Mt3KO:ANU","B6.129-Mt3<tm1Rpa>/Apb",null,"Recessive","metallothionein 3","Mt3","Nil","MT-3","MGI:97173","metallothionein 3; targeted mutation 1, Richard D Palmiter","Mt3<tm1Rpa>","MGI:2389488","8",{"$nulls":28},"Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury.","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Excellent",{"$nulls":3},"No","2014-01-17","Cryopreserved sperm"]
[6588,"BALB/c x NOD/Lt","Nod/Lt.C-Idd5<BALB/c> Idd1<BALB/c>/Arc",null,"Recessive",{"$nulls":37},"As per background strain.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2011-09-29","Embryo"]
[7248,"IGF1 Exon5 total KO","B6.Cg-Igf1<tm?.1Nros>/MarpApb",null,"Semi-dominant","insulin-like growth factor 1","Igf1","Nil","C730016P09Rik, Igf-1, Igf-I","MGI:96432",{"$nulls":3},"10",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-12-12","Cryopreserved sperm"]
[5345,"SS-11 ; Vegfd 2.2.36","C57BL/6-Figf<tm1Mach>/Apb",null,"X-linked","c-fos induced growth factor","Figf","Nil","VEGF-D, Vegfd","MGI:108037","c-fos induced growth factor; targeted mutation 1, Marc G Achen","Figf<tm1Mach>","MGI:3576785","X",{"$nulls":28},"No abnormal phenotype detected: homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.Mice have reduced numbers of lymphatic vessels in lungs.","Normal","129S1/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","0",null,null,"No","2010-12-15","Cryopreserved sperm"]
[7245,null,"NOD.B6 Idd9/11",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 9; C57BL/6J","Idd9<C57BL/6>","MGI:3036801","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-12-11","Embryo"]
[6891,"ENU24:G2","ANU:ENU24:G2",null,"Recessive",{"$nulls":37},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2012-05-04","Cryopreserved sperm"]
[7061,"Momme D38","FVB/NJ-MommeD38 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D38","MommeD38","Unknown",{"$nulls":5},"15",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (before E9.5 dpc)","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD38<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm"]
[7389,"ENU19:G2","ANU:ENU19:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2013-08-02","Cryopreserved sperm"]
[5358,"NOD.427","NOD-Tg(HLA DR4-DQ8)427/Apb",null,"Dominant",{"$nulls":25},"human leukocyte antigen class II",{"$nulls":11},"HLA DR4 and DQ3 expression was evident on B cell but not T cells, dendritic cells and a proportion of macrophages.DR4-DQ3 mice develop protective immunity following infectious challenge with S. typhimurium.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","19","7",null,"No","2010-12-20","Cryopreserved sperm"]
[6870,"APN126","C57Bl/6N-Ptcra<tm2a(EUCOMM)Hmgu>/MarpApb",null,"Recessive","pre T cell antigen receptor alpha","Ptcra","Unknown","pT-alpha, pT[a], pTalpha","MGI:104857","pre T cell antigen receptor alpha; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH","Ptcratm2a(EUCOMM)Hmgu","MGI:4434686","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-04-05","Cryopreserved sperm"]
[{"$nulls":30},"human leukocyte antigen class II"]
[4888,null,"129-Ctsg<tm1.1Roes>/H",null,"Dominant","cathepsin G","Ctsg","Nil",null,"MGI:88563","targeted mutation 1.1, Jurgen Roes","Ctsgtm1.1Roes","MGI:2182170","14",{"$nulls":28},"Decreased susceptibility to bacterial infection: median survival time is increased to 560 +/- 47 min compared to 435 +/- 8 min in wild-type miceIncreased susceptibility to fungal infection: after infection with 500,000 A. fumigatus spores median survival time was only 13 +/- 4 days compared to wild-type mice which all survive6 days after infection kidney fungal load (457 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-28","Cryopreserved sperm"]
[5677,"CD1d -/-",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5682,"Cep55-MMTV-cCe",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5690,"Clone 5.9",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5692,"CMV",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5696,"Col1a2 x B6 ROSA26A-EGFP ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5702,"Crim1 Flox CD1 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5707,"Crim1 KST264 CD1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5708,"Crystallin-MMTV-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5712,"Cx3cr1; Cx3cr1-GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5728,"Deb Black NesCreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5735,"Dicer,Flox,Math1,CRE",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5737,"Donkey pZAP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5745,"E2F8-/- (295/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5766,"EphA4Ko/129x1SVj",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5769,"Estella",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5770,"ExtraToes",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5779,"Fgf8floxC57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5789,"Fox 03 STAG",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5792,"FVBN",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5794,"GAD 67",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5802,"GFAP cre x C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5811,"GHR Null",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5816,"GolliTau/NF1B",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5817,"Gorgo (green)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5825,"Hes/Hey",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5830,"Hes5-EGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5832,"HIT 391",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5835,"HoxB7 GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5842,"ICE -/-xC57BL/6",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5850,"IL-23R KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5854,"IRF3-7",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5855,"IRF7",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5860,"K14Cre.FVB",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5867,"K14hGH023.C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5872,"Kamu",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5874,"KoAgc",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5879,"KoRap",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5884,"Lawrence ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5889,"Lox.stop.OVA F500",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5892,"Ly5.1 Tea x Balb/c ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5898,"Macblue ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5904,"Math 1 GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5913,"Mincle",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5914,"MMTVCre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5919,"Mortlock",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5925,"Nas1 C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5932,"Nestin GFP (PN18)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5953,"NXAT x Emx1Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5958,"OIM",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5963,"OSMR-1-",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5969,"P40",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5970,"P53HetBrca1WT (P53 Het)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5976,"PCX: kik",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5981,"Pik3cd",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5985,"PRLR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5986,"Prox 1 GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5990,"PTc Cond",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5995,"Ptch 1 Balbc",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6000,"PTPRCA",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6001,"PTRF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6007,"R26R Flox/Flox",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6010,"Rac2 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6015,"RaOpxC57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6016,"RB flox/flox",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6021,"RelbKO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6028,"Robo1LoxPC57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6036,"Rolfe/Mooney - C57BL/6J (712/08)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6037,"RORg-loxP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6043,"ROSA26A-EGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6046,"rtTA-Nagy",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6051,"Schlafen Fuzzy",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6052,"Sez 6",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6056,"Sirt/NestinCreCROSS",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6061,"Sirt1/NestinCre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6066,"Six2 Flox/Flox",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6069,"SKG ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6071,"Ski tm1 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6078,"Slit3C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6083,"SOD 1 x Thyl-YFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6084,"SOD1*G93A",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6088,"SOD1G93A1Gur",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6093,"Sox 9 Ptch 1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6098,"SRY 5.7",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6101,"SRY clone 18.2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6103,"SRY49,29",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6108,"Stra 8 2.5 clone C108",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6113,"Super16TOPFLASH x C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6114,"Super16Topflash x RaOp",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6118,"Tagln - Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6123,"Teague",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6126,"Tet0-NFIB2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6128,"Teto-Nf1B2/rtta-nagy",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6133,"Tg(Thy-1-CFP)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6138,"Thy1CFP x Sod1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6140,"Tie-1 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6143,"Tindall N10",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6148,"TNF?ARE X ERAP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6153,"Topflash x C57  ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6156,"Transgelin Rosa",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6158,"Tubbs3 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6163,"TVU",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6168,"Tyr Cre/ Ptc1 C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6170,"Vamp8 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6173,"Vgat x Komusk",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6178,"Wnt1-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6183,"Z Crim",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[5360,"NOD.hCD4.IAE.303-4 ; NOD triple 303","NOD-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR3-DQ2)303/Apb",null,"Dominant","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No","human leukocyte antigen class II",{"$nulls":11},"Expression of HLA DR and DQ evident on B cells, dendritic cells and a proportion of macrophages.These mice Tg for hCD4.DR3-DQ2.MHCII<Δ/Δ> express functional HLA-DR3 and DQ2 molecules that mediate thymic selection generating Ag-specific CD4<+> T cell immunity. Although about one in five Europeans homozygous for HLA-DQ2 develops celiac disease, homozygous and heterozygous hCD4.DR3-DQ2.MHCII<Δ/Δ> Tg mice do not spontaneously develop hypersensitivity to gluten. However, standard immunization protocols do produce HLA-DQ2-restricted CD4+ T cells in hCD4.DR3-DQ2.MHCII<Δ/Δ> Tg mice that preferentially recognize the deamidated α-gliadin 17-mer immunodominant in human celiac disease. Nevertheless, we have found that preexisting DQ2-restricted CD4<+> T cell immunity to deamidated α-gliadin 17-mer in hCD4.DR3-DQ2.MHCII<Δ/Δ> Tg mice is not sufficient for gluten ingestion to cause measurable intestinal pathology.On the NOD background mice immunised with gliadin and co-injected with pertusis toxin remained healthy.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21","Cryopreserved sperm"]
[8718,"FANCM KO","FVB-Fancm<em2>/StVApb",null,"Recessive","Fanconi anemia, complementation group M","Fancm","Nil","C730036B14Rik, D12Ertd364e","MGI:2442306",{"$nulls":3},"11",{"$nulls":28},"Reduced fertility: smaller testis and epidydmis. Reduced sperm count and sperm motility.May have decreased lifespan.May have increased cancer susceptibility.","May have increased cancer susceptibility.","FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-05-23","Cryopreserved sperm"]
[7400,"Ins2-Cre","B6.Cg-Tg(Ins2-cre)25Mgn/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 25, Mark A Magnuson ","rat insulin promoter (Ins2)","9 copies",{"$nulls":9},"Expression of Cre recombinase in pancreatic beta cells and hypothalamus.","Expression of Cre recombinase in pancreatic beta cells and hypothalamus.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-08-16"]
[7401,"Senp2 Gt","B6;C3-Senp2<Gt((V0002-D)4004-321>/RbrcAnu",null,"Recessive","SUMO/sentrin specific peptidase 2","Senp2","Unknown","2310007L05Rik, 4930538C18Rik, mKIAA1331","MGI:1923076",{"$nulls":3},"16",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-08-20"]
[7406,"ENU22 Bcl2:019:a","ANU:ENU22 Bcl2:019:a",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Low CD4's, increased CD25's and CD44hi","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-08-21","Cryopreserved sperm"]
[7617,"Helios floxed","B6.Cg-Ikzf2<tm1.1Etms> Tg(CD4-Cre)/Anu",null,"Recessive","IKAROS family zinc finger 2","Ikzf2",null,"A730095J18Rik, Helios, Zfpn1a2","MGI:1342541","IKAROS family zinc finger 2; targeted mutation 1.1, Ethan M Shevach","Ikzf2<tm1.1Etms>","MGI:4456473","1",{"$nulls":16},"transgene insertion 1, Christopher B Wilson","CD4",{"$nulls":10},"Abnormal regulatory T cell physiology:• regulatory T cells fail to respond to TCR stimulation or IL2 unlike wild-type cells• however, regulatory T cells respond normally to anti-CD3 and IL2 and are as suppressive as wild-type regulatory T cells",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-03-07","Cryopreserved sperm"]
[7412,"ENU27:007:ETS1","C57BL/6NCrlAnu-Ets1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Ets1<m1Anu>/AnuApb","Recessive","E26 avian leukemia oncogene 1, 5' domain","Ets1","Unknown","Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1","MGI:95455","E26 avian leukemia oncogene 1, 5' domain; mutation 1, The Australian National University","Ets1<m1Anu>","MGI:5563474","9","ENSMUSG00000032035","ENSMUST00000034534","Ets1-001","1001","1363","C to T","ENSMUSE00000537123","7","334","Proline to Leucine",{"$nulls":4},"TGCCCTGGCTGGCTACACAGGAAGTGGGCCGATCCAGCTGTGGCAGTTTCTTCTGGAATTA",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, C4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-08-23","Cryopreserved sperm"]
[7417,"ENU27:043:ZFP644","C57BL/6NCrlAnu-Zfp644<m1Anu>/AnuApb","C57BL/6NCrlAnu-Zfp644<m1Anu>/AnuApb","Recessive","zinc finger protein 644","Zfp644","Unknown","1110068L01Rik, BM-005, D5Ertd689e, mKIAA1221, Zep-2","MGI:1277212","zinc finger protein 644; mutation 1, The Australian National University","Zfp644<m1Anu>","MGI:5563394","5","ENSMUSG00000049606","ENSMUST00000112698","Zfp644-201",{"$nulls":7},"106638637","2",null,null,"GCAAATCTACATTTTTGTTTTCCATTTTCTAGACTAAAGGTGTTAAATGATCTTGCCAAC",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-08-23","Cryopreserved sperm"]
[7423,null,"SJL/ASAM<MRI135091>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays an harmonious growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","3",null,null,"No","2013-08-27","Cryopreserved sperm"]
[7425,null,"B6/Mrit-MRI95318","B6/Mrit-MRI95318","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display an harmonious and transient growth retardation","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-08-27","Cryopreserved sperm"]
[7421,null,"SJL/Mrit-Tfrc<MRI97707>Apb",null,"Dominant","transferrin receptor","Tfrc","Reduced","2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr","MGI:98822",{"$nulls":3},"16",{"$nulls":28},"Prenatal mortality (E15) with severe anaemia and fragmented red blood cells","Heterozygous mice display a microcytic anaemia with decrease osmotic fragility.","SJL/J","No","No","Yes","No","No","Yes","No","Good","4",null,null,"No","2013-08-27","Cryopreserved sperm"]
[6589,"BALB/c-2","Nod/Lt.C-Idd5<BALB/c> Idd1<BALB/c> Ubash3a<rs48725557-C>/Arc",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 5","Idd5",null,"Idd-5","MGI:96407","insulin dependent diabetes susceptibility 5; BALB/c","Idd5<BALB/c>",null,"1","As per background strain.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","3",null,null,"No","2011-09-29","Embryo"]
[8720,"Tlr9 KO","B6.129-Tlr9<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 9","Tlr9","Nil",null,"MGI:1932389","toll-like receptor 9; targeted mutation 1, Shizuo Akira","Tlr9<tm1Aki>","MGI:2660562","9",{"$nulls":28},"Tlr9 KO mice have:Abnormal immune system physiology:*Response to LPS and CpG is completely abrogated.      Impaired NK cell cytolysis:      *No NK cell activation is observed following infection with L. infantum.      Decreased interferon-alpha secretion:      *Following infection with Leishmania baziliensis.      *However, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.      Decreased interferon-beta secretion:      *Following infection with Leishmania baziliensis.      *However, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.      Decreased interleukin-12b secretion:      *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice.      *Unlike in wild-type mice, IL-12p40 production from dendritic cells following infection with Leishmania infantum is indetectable.      Decreased tumor necrosis factor secretion:      *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.      Decreased susceptibility to experimental autoimmune encephalomyelitis:      *Myelin oligodendrocyte glycoprotein injection results in delayed onset of disease, 17.9 days after injection rather than 15.9 days as in controls.      *Fewer infiltrating foci in the spinal cord.      Abnormal response to infection:      *Following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a partially decreased immune response in terms of TNF secretion and response to CpG.         Decreased susceptibility to parasitic infection:         *Resistant to cerebral malaria.         *Reduced accumulation of hemozoin.         *Less upregulation of TNF-alpha in Plasmodium infection.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",">10",null,"heterozygote mating","No","2019-05-30","Cryopreserved sperm"]
[5058,"Cauli ; ENU12B6:C3H:003","B6;C3H-Ift140<cauli>/AnuApb","B6;C3H-Ift140<cauli>/AnuApb","Recessive","intraflagellar transport 140 homolog (Chlamydomonas)","Ift140",null,"mKIAA0590, Tce5, Wdtc2 ","MGI:2146906 ","cauli","Ift140<cauli>","MGI:4458412","17","ENSMUSG00000024169","ENSMUST00000024983","Ift140-001","2564","3109","T to A","ENSMUSE00000551541","19","855","Isoleucine to Lysine",{"$nulls":4},"ACTGGAAGCCAGAGTGGCCATGCTGGCCATACAGCTGGGCATGCTGGAGGAGGCAGAACAA","Yes",{"$nulls":12},"Phenotype found in 13.5 dpc embryo. Phenotype is exencephaly, hind limb polydactyly, forelimbs have a mixture of polydactyly and oligodactyly and midfacial cleft.","Normal","C57BL/6 x C3H","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2007-05-02","Cryopreserved sperm"]
[6617,"ENU23 MDX:::B6:F1","ANU:ENU23MDX:F1",null,"X-linked","dystrophin, muscular dystrophy","Dmd","Unknown","Dp427, Duchenne muscular dystrophy, mdx, pke, X-linked muscular dystrophy","MGI:94909","X linked muscular dystrophy","Dmd<mdx>","MGI:1856328","X",{"$nulls":15},"No",{"$nulls":12},"Abnormal muscle morphology.dilated sarcoplasmic reticulum.Abnormal skeletal muscle fiber morphology: * development of electron-dense bodies in the mitochondria resulting in swelling and degenerating mitochondria, and disruption of the plasmalemma basal lamina. * the normal myofibrillar architecture of bands and lines disappears and myofilaments disintegrate and become misaligned.Increased variability of skeletal muscle fiber size: variable muscle fiber size; progressive starting at 3 weeks of age.Skeletal muscle fibrosis: exhibit mild muscle fibrosis, however there is no replacement of lost muscle by fat cells.Skeletal muscle necrosis: progressive starting at 9 weeks of age.Muscle degeneration: progressive starting at 3 weeks of age.Abnormal muscle physiology: increased intracellular sodium concentration in muscle; increased severity with age.Muscular atrophy: progressive starting at 3 weeks of age.Dystrophic muscle.Myopathy: progressive degenerative myopathy; increased severity with age.Abnormal circulating enzyme level: exhibit elevated blood levels of muscle creatine kinase and pyruvate kinase.Reduced female fertility: slight reduction in fertility.",null,"C57BL/6 x C57BL/10","Unknown","Unknown","Yes","Unknown","Unknown","Yes","Yes","Unknown",{"$nulls":3},"No","2011-10-14","Cryopreserved sperm"]
[7434,"Mink","B6.129S6-Kcne1<tmRdn>/Apb",null,"Dominant","potassium voltage-gated channel, Isk-related subfamily, member 1","Kcne1","Nil","Isk, MinK, nmf190","MGI:96673","potassium voltage-gated channel, Isk-related subfamily, member 1; targeted mutation 1, Dan M Roden","Kcne1<tm1Rdn>","MGI:3040614","16",{"$nulls":28},"Lethal","Normal,fertile, viable","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-09-16","Cryopreserved sperm"]
[5386,"Fat Aussie","NOD.B10-Alms1<foz>/AnuApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Mice are hyperphagic leading to obesity and diabetes. Males are sterile. High fat feeding accelerates obesity and diabetes development, and leads to nonalcoholic steatohepatitis which progresses to liver fibrosis.Insulin resistance: female mice develop insulin resistance by 200 days of age.Increased eating behavior: mutants eat more than wild-type.Abnormal hepatocyte morphology: mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells.Enlarged liver: mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g).Increased liver weight: liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g).Liver fibrosis: mutant livers show pericellular and pericentral fibrosis.Hepatic steatosis: chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis.","Normal","NOD.B10","Yes","Yes","Yes","Yes","No","Yes","Yes","Excellent",">10",null,"heterozygote mating","No","2011-01-17","Cryopreserved sperm"]
[7436,null,"C3;SJL/Mrit-MRI16932","C3;SJL/Mrit-MRI16932","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a slight growth retardation phenotype","SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-09-19","Cryopreserved sperm"]
[4798,"ENU:G1 library","WEHI:ENU:G1",null,"Dominant",{"$nulls":37},"Random induced point mutations.Library. Sperm and DNA stored",null,"C57BL/6 x C3H x BALB/c ?","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[6807,"Larry","SJL/Mrit-Krt25<MRI31977>/MriApb",null,"Dominant","keratin 25","Krt25",null,"4631426H08Rik, mIRSa1","MGI:1918060",null,"Krt25<MRI31977>",null,"11",{"$nulls":28},"Curly coat and curly whiskers ","Curly coat and curly whiskers ","SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-02-01","Cryopreserved sperm"]
[7448,"WEHI:G1:Snrnp48","STOCK Snrnp48<m1WEHI>/WehiApb",null,"Recessive","small nuclear ribonucleoprotein 48 (U11/U12)","Snrnp48","Unknown","1110050F08Rik, 6530403A03Rik","MGI:1915047","mutation 1, Walter and Eliza Hall Institute","m1<Wehi>",null,"13","ENSMUSG00000021431","ENSMUST00000091641","Snrnp48-201","794","828","A to G","ENSMUSE00000117800","7","265","Aspartic acid to Glycine",{"$nulls":4},"CTGGCAGGAAGAGCAGGGGAGAGCAGGAGACGCTGCTGAGAAGAATGAAGAAAGGCGGTCA",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-09-26"]
[7451,"hPlg1","B6.SJL/J-Tg(Alb-PLG/EGFP)",null,"Dominant",{"$nulls":25},"human plasminogen","murine albumin (Alb)","17%",{"$nulls":9},"NA","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Plg trans +ve x Plg trans +ve ","No","2013-10-08"]
[5392,"Adam22","B6;CBA-Adam22<tm1Sag>/Apb",null,"Recessive","a disintegrin and metallopeptidase domain 22","Adam22","Nil","MDC2","MGI:1340046","a disintegrin and metallopeptidase domain 22; targeted mutation 1, Koji Sagane","Adam22<tm1Sag>","MGI:3584137","5",{"$nulls":15},"Yes",{"$nulls":12},"Complete postnatal lethality: start to die after P10 and all die before P20.Ataxia: * all display severe ataxia after P10 * unable to support themselves on hindlimbs at P18Convulsive seizures: occasionally observe convulsive seizures.Decreased body size.Decreased body weight: average body weight is approximately half that of controls at P10.Abnormal Schwann cell morphology: higher density of pro-myelinating Schwann cells in the sciatic nerve and delay in differentiation of Schwann cells.Abnormal myelination: lack of myelin or thin myelin in the sciatic nerves and trigeminal nerves, however myelin formation in spinal cord and brain is normal.Abnormal glial cell morphology: enteric sections exhibit fewer glial cells than in wild-type mice.Abnormal neuron morphology: cultured primary neurons cannot be myelinated by Rat Schwann cells unlike similarly treated neurons from heterozygous mice.Demyelination: * in the sciatic nerve at P12 that is less severe than in Lgi4<clp> homozygotes * of peripheral nerves","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-01-24","Cryopreserved sperm"]
[6648,"APN 141","C57BL/6N-1110008L16Rik<Gt(IST12983B7)Tigm>/Marp",null,"Recessive","RIKEN cDNA 1110008L16 gene","1110008L16Rik ","Unknown",null,"MGI:1913382 ","RIKEN cDNA 1110008L16 gene; gene trap IST12983B7, Texas A&M Institute for Genomic Medicine ","1110008L16RikGt(IST12983B7)Tigm","MGI:4105973","12",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-11-22","Cryopreserved sperm"]
[5521,"F/F x Tlr2; gp130Y757F x Tlr2","B6;129(Cg)-Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop gastric and inflammation and tumours, as well as splenomegaly and lymphadenopathy.","If the mice are heterozygous for the gp130 knock-in mutation (F+) then the mice appear normal. ","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good","10",null,"heterozogous x homozygous","No","2011-06-10","Cryopreserved sperm"]
[5521,"F/F x Tlr2; gp130Y757F x Tlr2","B6;129(Cg)-Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","toll-like receptor 2","Tlr2","Nil","Ly105","MGI:1346060","toll-like receptor 2; targeted mutation 1, Shizuo Akira","Tlr2<tm1Aki>","MGI:2178675","3",{"$nulls":15},"No"]
[7463,"gp130Y757F/gp130Y757F x ApoE-/- x Stat3-/+","B6.Cg-Apoe<tm1Unc> Il6st<tm1Ern> Stat3<tm1Aki>/MarpApb",null,"Recessive","signal transducer and activator of transcription 3","Stat3","Nil","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 1, Shizuo Akira","Stat3<tm1Aki>","MGI:1926814","11"]
[7462,"BATGal","B6.D2-Tg(BAT-lacZ)3Picc/VccriApb",null,"Dominant",{"$nulls":25},"transgene insertion 3, Stefano Piccolo","Seven TCF/LEF-binding sites fused upstream of a 0.13-kb fragment containing the minimal promoter–TATA box of the gene siamois",{"$nulls":10},"Normal phenotype, expresses LacZ reporting Wnt signalling.Beta-galactosidase expression is initially detectable at E6 in posterior side of proximal epiblast and is observed in the posterior primitive streak and node at gastrulation, progressing to the paraxial mesoderm and notochord.","Normal phenotype, expresses LacZ reporting Wnt signalling","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","0","BATGal +/- (hemizygous) mated with C57BL/6","No","2013-10-22","Cryopreserved sperm"]
[7470,"GzmB Cre","STOCK Gt(ROSA)26Sor<tm1(EYFP)Cos> Tg(Gzmb-cre/ERT2)1Dtf/MarpApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":16},"transgene insertion 1, Douglas T Fearon","granzyme B",{"$nulls":10},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2013-11-07","Cryopreserved sperm"]
[7466,"ENU22:MED28:G1","C57BL/6NCrlAnu-Med28<m1Anu>/AnuApb",null,"Recessive","mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)","Med28",null,"1500003D12Rik, Eg1, magicin","MGI:1914249","mediator complex subunit 28; mutation 1, The Australian National University","Med28<m1Anu>","MGI:5570703","5","ENSMUSG00000015804","ENSMUST00000156481","Med28-001","275","380","A to G","ENSMUSE00001257470","3","92","Glutamic acid to Glycine",{"$nulls":4},"GAAGTTTTTGGACATTGCAAGACAGACAGAATGTTTTTTCCTACAAAAAAGGTTGCAGTTA","Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",null,"1",null,"No","2013-10-29","Cryopreserved sperm"]
[7472,"Maspin KO","C57BL/6J-SerpinB5<tm1.1Pib>/PibMarpApb",null,"Dominant","serine (or cysteine) peptidase inhibitor, clade B, member 5","Serpinb5",null,"1110036M19Rik, Maspin, ovalbumin, Spi7","MGI:109579",{"$nulls":3},"1",{"$nulls":28},"Unknown","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-11-11","Cryopreserved sperm"]
[7471,"square head","C57BL/6-Pfas<ASAM131144>/Apb",null,"Dominant","phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)","Pfas","Unknown","4432409B16Rik, Sofa","MGI:2684864",{"$nulls":3},"11","ENSMUSG00000020899","ENSMUST00000021282","Pfas-001","2099","2192","T to C","ENSMUSE00001246828","18","700","Lysine to Proline",{"$nulls":4},"TGTTGCCCAACAGCAGTGTGTCGGACCCCTGCAGACTCCTCTGGCTGATGTGGCTGTTGTA",{"$nulls":13},"Unknown","Heterozygous mice displays a short snout, domed cranium and a decreased body weight.","C57BL/6","No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2013-11-07","Cryopreserved sperm"]
[7484,"Clock Mel","CBA;B6-Clock<m1Jt>/Apb",null,"Semi-dominant","circadian locomotor output cycles kaput","Clock",null,"5330400M04Rik, bHLHe8, KAT13D, mKIAA0334","MGI:99698","circadian locomotor output cycles kaput; Clock","Clock<m1Jt>","MGI:1861634","5",{"$nulls":28},"The mutant animals displays an altered period of rhythmicity of wheel running activity in constant darkness (approx 27 hours), followed by arrythmicity after an extended period.","The heterozygote displays a slightly longer period of behavioural rhythmicity in constant darkness (approx 24.5 hours).","CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","4","0","Maintain mutant and wild type as separate lines.","No","2013-11-14","Cryopreserved sperm"]
[7485,"WinSlpi","B6.129P2-Muc2<wnn> Slpi<tm1Nkw>/Apb","UTAS","Recessive","mucin 2","Muc2","Unknown",null,"MGI:1339364","mucin 2; winnie","Muc2<wnn>","MGI:3614806","7",{"$nulls":28},"No explicit phenotype, normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-14","Cryopreserved sperm"]
[8725,"ACAD10KO","C57BL/6-Acad10<em1>/Apb",null,"Recessive","Acyl-CoA Dehydrogenase Family Member 10","Acad10",null,"2410021P16Rik","MGI:1919235",{"$nulls":3},"5",{"$nulls":28},"Normal as far as initial experiments have shown","Normal as far as initial experiments have shown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-05","Cryopreserved sperm"]
[7492,"PRLRfx","B6.Cg-Prlr<tm1.1?>/Ausb",null,"Recessive","prolactin receptor","Prlr","Unknown",null,"MGI:97763",{"$nulls":3},"15",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-19"]
[8726,"NR.Triple427.huPI","NOD.129S7B6-Rag1<tm1Mom> H2<d1Ab1Ea2> Ins1<em1(INS)Tkay> Tg(hCD4) Tg(HLA-DR4, HLA-DQ8)/Tkay",null,"Recessive","insulin I","Ins1",null,null,"MGI:96572","INS knockin","em1(INS)Tkay",null,"19",{"$nulls":16},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":9},"Normal","Normal","NOD.129S7.B6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-06","Cryopreserved sperm"]
[8726,"NR.Triple427.huPI","NOD.129S7B6-Rag1<tm1Mom> H2<d1Ab1Ea2> Ins1<em1(INS)Tkay> Tg(hCD4) Tg(HLA-DR4, HLA-DQ8)/Tkay",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17"]
[5116,"ENU11B6-C3H:005 ; bfb","B6;C3H-Fras1<bfb>/AnuApb","B6;C3H-Fras1<bfb>/AnuApb","Recessive","Fraser syndrome 1 homolog (human)","Fras1","Unknown","bl, E130113P14Rik, mKIAA1500","MGI:2385368","Fraser syndrome 1 homolog (human); blood filled blisters","Fras1<bfb>","MGI:5463442","5","ENSMUSG00000034687","ENSMUST00000036019","Fras1-201","10762","11620","T to C","ENSMUSE00000318929","69","3588","Serine to Proline",{"$nulls":4},"AGCTCTTGTGGAGTGCTCAGACATTTGATTCTCCTCATCAACTCTGGCGAGCCACGAGCTC","Yes",{"$nulls":12},"Embryonic lethal.Cleft secondary palate:• at E18.5Eyelids open at birth:• at E18.5Bleb• blood filled blisters on the head and feet at E13.5.Preaxial polydactyly:• at E18.5Absent kidney:• at E18.5Cleft secondary palate:• at E18.5",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-05-11","Cryopreserved sperm"]
[8705,"gBT-I.1","C57BL/6-Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn/CbnAnu",null,"Dominant",{"$nulls":25},"transgene insertion L118-1, Francis R Carbone ","a 2 kb fragment of the H-2Kb and a 700 bp fragment including the Igh enhancer.",{"$nulls":10},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenotype from wild-type B6 mice.T cells express Va2<+>Vb8<+> TCR derived from the K,B> restricted HSV-1 glycoprotein B (gB498-505)-specific CTL clone HSV2.3.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-05-02","Cryopreserved sperm"]
[6784,"APPPS1B6C3","B6.C3-Tg(APPswe,PSEN1dE9)85Dbo/JAusb","B6.C3-Tg(APPswe,PSEN1dE9)85Dbo/JAusb","Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","mouse prion protein ","Predominantly to CNS neurons",{"$nulls":9},"Unknown","Mice develop beta amyloid deposits in brain by 6 or 7 months of age. The humanized Mo/HuAPP695swe transgene allows the mice to secrete a human A-beta peptide.A slight alteration in the tail can occur due to mixed background.","B6/C3","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",null,null,"Maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice","No","2012-01-18","Cryopreserved sperm"]
[5467,"D6","B6.129/Sv-Ccbp2<tm1Gjg>/Apb",null,"Recessive","chemokine binding protein 2","Ccbp2","Nil","CCR10, CCR9, Cmkbr9, D6","MGI:1891697","chemokine binding protein 2; targeted mutation 1, Gerard J Graham","Ccbp2<tm1Gjg>","MGI:3623613","9",{"$nulls":15},"Yes",{"$nulls":12},"Increased inflammatory response: * subcutaneous injection of complete Freund's adjuvant (CFA) produces a granuloma-like lesion in homozygotes by 3 days post injection and 18 of 28 mutants develop grade 2 or higher lesions by 7 days post injection versus 2 of 28 wild-type mice * at the site of CFA injection increased necrosis, angiogenesis and leukocyte infiltration are seen * 3 days after CFA injection increase lymph node cellularity is seen in homozygotes compared to wild-type mice; however 7 days after injection wild-type contralateral lymph nodes display hyperplasia which is not seen in homozygotes.Dermatitis: * 24 hours after a single exposure of dorsal skin to 12-O-tetradecanoylphorbol-13-acetate (TPA) beta-chemokine levels remain elevated suggesting a defect in post-inflammatory clearance. * after 3 daily applications of TPA homozygotes develop a psoriasis-like skin lesion that is characterized by skin thickening, basal and suprabasal epidermal hyperproliferation, severe epidermal acanthosis, parakeratosis, hyperkeratosis, extensive growth of convoluted blood vessels, and a dense inflammatory cell infiltrate that includes high numbers of T cells * this TPA-induced inflammatory skin lesion persists for 6 to 10 days. * injection of TNF neutralizing antibodies, depletion of CD4+ and CD8+ T cells, or blockage of mast cell degranulation can prevent development of the TPA-induced psoriaform lesion.",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-03-22","Cryopreserved sperm"]
[5315,"BALB.SHIP-1 knockout","C.129P2(B6)-Inpp5d<tm1Dmt>/JAcbdLudApb","C.129P2(B6)-Inpp5d<tm1Dmt>/JAcbdLudApb","Recessive","inositol polyphosphate-5-phosphatase D","Inpp5d","Nil","s-SHIP, SHIP, SHIP-1, SHIP1, Src homology 2 domain-containing inositol-5-phosphatase","MGI:107357","inositol polyphosphate-5-phosphatase D; targeted mutation 1, Dan Dumont","Inpp5d<tm1Dmt>","MGI:1861956","1",{"$nulls":15},"No",{"$nulls":12},"Young mice are apparently healthy, and do not develop inflammatory lung disease, unlike mixed genetic background or C57BL/6 background SHIP-1<-/-> mice. ","No obvious disease is apparent in SHIP-1<+/-> mice, even at 12 months of age.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","7",null,null,"No","2010-11-10","Cryopreserved sperm"]
[6445,"GEM?","B6.Cg-Gem<tm1.1>/?Ausb",null,"Recessive",null,"GEM",{"$nulls":37},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6699,"Ga1","B6.Cg-Gad1<tm1Tama>/Ausb",null,"Dominant","glutamic acid decarboxylase 1","Gad1","Normal","EP10, Gad-1, GAD25, GAD44, GAD67, Z49976 ","MGI:95632 ","glutamic acid decarboxylase 1; targeted mutation 1, Nobuaki Tamamaki","Gad1<tm1Tama>","MGI:3590300","2",{"$nulls":30},"C57BL/6","No","Unknown","Yes","No","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[5248,"Lyn STAT6 double knockout ; BALB.Lyn-/-STAT6-/-","C.Cg-Lyn<tm1Ard> Stat6<tm1Aki>/Apb",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No"]
[8731,"Foxo1flox:Mb1CreERT2:B1-8:Tomato","B6.129-Cd79a<tm3(cre/ERT2)Reth> Foxo1<tm1Flv> Igh<tm1Mnz> Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>/AnuApb",null,"Recessive","forkhead box O1","Foxo1","Normal","Afxh, FKHR, Fkhr1, Foxo1a","MGI:1890077","forkhead box O1; targeted mutation 1, Richard A Flavell","Foxo1<tm1Flv>","MGI:3840910","3",{"$nulls":28},"Normal",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-12","Cryopreserved sperm"]
[2,"Unmodulated","C57BL/6JSfdAnu-Card11<unm>/AnuApb","C57BL/6JSfdAnu-Card11<unm>/AnuApb","Recessive","caspase recruitment domain family, member 11","Card11","Normal","CARMA1, BIMP3","MGI:1916978","unmodulated","Card11<unm>","MGI:3045963","5","ENSMUSG00000036526","ENSMUST00000085786","Card11-201","914","1235","T to A","ENSMUSE00000431473","7","305","Leucine to Glutamine",{"$nulls":4},"TGACTCAGACAAGGCCATCTTGGACATCCTGGAACATGACCGGAAGGAGGCGCTAGAGGAC","Yes",{"$nulls":12},"Diminished antibody formation upon T cell-independent type 2 and T cell-dependent immunization. Diminished B cell NFκB activation and proliferation to antigen receptor engagement, but normal proliferation to TLR4 stimulation. Failure to form normal IgMlow IgDhi follicular B cells, and failure to form peritoneal B1 B cells. Diminished T cell NFκB activation and proliferation to TCR+CD28 stimulation. Spontaneous dermatitis accompanied by dermal mastocytosis and hyper-IgE syndrome.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",{"$nulls":3},"No","2005-11-25","Cryopreserved sperm"]
[28,"Armadillo","STOCK H2<k2> Dsg4<arm>/AnuApb","STOCK H2<k2> Dsg4<arm>/AnuApb","Recessive","desmoglein 4","Dsg4","Unknown","CDHF13, lah","MGI:2661061","armadillo","Dsg4<arm>","MGI:3846150","18",{"$nulls":15},"No",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k2 variant","H2<k2>","MGI:4936842","17","Hairless and wrinkly. The Armadillo mice have a very short hair coat all over the body. The short hair is most pronounced on the extremities, eg. Ears, tail, muzzle and limbs up to the hock and elbow, and ventrally. The hair dorsally looks more normal, but it appears to lack guard hairs. This appearance is possibly due to breakage of all hair follicles causing an overall shorter appearance to the coat. The skin also appears slightly hyperaemic (reddened), but this could just be due to less hair coverage. The affected mice appear to have no whiskers and are also smaller than normal littermates. On histology, the most obvious feature is generalised epidermal hyperplasia. The affected mice also have an \"onion bulb\"\u001d appearance to the base of the hair follicle. Above this is an area of bright orange/pink staining which suggests premature cornification of the hair shaft and adjacent inner root sheath. Some mice had a mild neutrophilic infiltrate into the dermis and some mice had focal pink swellings of the hair fibres. The hair follicle produced is abnormal and prone to breakage resulting in short hair.  ",null,"C57BL/6JSfdAnu x B10.BR-H2<k2>","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"6","Affected male by unaffected female","No","2006-02-06","Cryopreserved sperm"]
[8733,"ENU31:075:Irf2","C57BL/6NCrlAnu-Irf2<m1Anu>/AnuApb",null,"Recessive","interferon regulatory factor 2","Irf2",null,"9830146E22Rik, Irf-2","MGI:96591",{"$nulls":3},"8",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-17","Cryopreserved sperm"]
[5237,"Warpy ; ENU15embryo:006 ; Marawarpina","C57BL/6JAnu-Dzip1l<warpy>/AnuApb","C57BL/6JAnu-Dzip1l<warpy>/AnuApb","Recessive","DAZ interacting protein 1-like","Dzip1l",null,null,"MGI:1919757","DAZ interacting protein 1-like; Warpy","Dzip1l<warpy>","MGI:5563494","9","ENSMUSG00000037784","ENSMUST00000078367","Dzip-1l-001","1123","1326","C to T","ENSMUSE00000325142","8","375","Glutamine to STOP",{"$nulls":4},"TGTCTCAGGACCAGAAGAAAGCAGCTGCCCAGTCTCAGCGCCATATCAATGCCCTCCGTGC","Yes",{"$nulls":12},"Polydactlyly and craniofacial dismorphology in embryos at e14.5.Extra digits on each limb some have 6 some have 7) and there is a craniofacial dismorphology (the front of the head protrudes, the eye position is changed and there is a mandible malformation.","Normal","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",null,"G1",null,"No","2010-10-12","Cryopreserved sperm"]
[5530,"ENU16WT:029","C57BL/6JAnu-Inpp5d<m1Anu>/AnuApb","C57BL/6JAnu-Inpp5d<m1Anu>/AnuApb","Recessive","inositol polyphosphate-5-phosphatase D","Inpp5d","Unknown","s-SHIP, SHIP, SHIP-1, SHIP1, Src homology 2 domain-containing inositol-5-phosphatase","MGI:107357","inositol polyphosphate-5-phosphatase D; mutation 1, The Australian National University","Inpp5d<m1Anu>","MGI:5563462","1","ENSMUSG00000026288","ENSMUST00000169754","Inpp5d-001","1411","1588","T to C","ENSMUSE00000157571","12","471","Serine to Proline",{"$nulls":4},"AGAAGGAGTGGCTGGAGCTACTCAGGCACTCCCTGCAAGAAGTCACCAGCATGACATTTAA",{"$nulls":13},"Animals begin to show signs of ill health between 7 and 12 weeks of age.  Examination by pathologist of an affected animal gave the following report:1.Intra-alveolar acidophilic macrophage pneumonia with scattered microhaemorrhages. A superimposed recent suppurative bronchiolar pneumonia with microabscesses and early bronchitis.2.Histiocytic (B cell) Lymphoma involving mediastinal lymph nodes, lung, spleen and small intestine.3.The micromorphological changes in the lymphoid tissues were examined by three Veterinary Histopathologists and by consensus there was agreement that there was a histiocytic B cell type of lymphoma involving nodes, lung, small intestine and spleen (minimally).","Macroscopically normal.  Detailed pathology not performed.","C57BL/6JAnu","No","Unknown","Yes","No","Unknown","Yes","No","Good",null,null,"Het x Het","No","2011-07-06","Cryopreserved sperm"]
[5406,"GM.G CSF.C57 (L-01) ;GM(-/-) G(-/-). C57","C57BL/6-Csf2<tm1Ard> Csf3<tm1Ard>/LudApb",null,"Recessive","colony stimulating factor 3 (granulocyte)","Csf3","Nil","Csfg, G-CSF, MGI-IG","MGI:1339751","colony stimulating factor 3 (granulocyte); targeted mutation 1, Ashley R Dunn","Csf3<tm1Ard>","MGI:1857155","11",{"$nulls":15},"No"]
[5206,"theoden ; ENU4AT:050 ","STOCK H2<k>/H2<b> Fas<theo>/AnuApb","STOCK H2<k>/H2<b> Fas<theo>/AnuApb","Recessive","Fas (TNF receptor superfamily member 6)","Fas","Nil","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","theoden","Fas<theo>","MGI:4455060","19","ENSMUSG00000024778","ENSMUST00000025691","Fas-201","416","422","G to A","ENSMUSE00000144910","4","139","Cysteine to Tyrosine",{"$nulls":4},"CTACTGCGATTCTCCTGGCTGTGAACACTGTGTTCGCTGCGCCTCGTGTGAACATGGAACC","Yes",{"$nulls":3},"Histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Antinuclear autoantibodies, lymphadenopathy.",null,"C57BL/6JStdAnu x C57BL/10.Cg-H2<k>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-08-16","Cryopreserved sperm"]
[1,"Plastic","C57BL/6JSfdAnu-Ikzf1<plstc>/AnuApb","C57BL/6JSfdAnu-Ikzf1<plstc>/AnuApb","Recessive","IKAROS family zinc finger protein 1","Ikzf1","Nil","Ikaros, hlk-1, LyF-1, Zfpn1a1","MGI:1342540","plastic","Ikzf1<plstc>","MGI:2669987","11","ENSMUSG00000018654","ENSMUST00000076700","Ikzf1-201","572","842","A to G","ENSMUSE00000655504","5","191","Histidine to Arginine",{"$nulls":4},"CTGCCGCCGGAGGGACGCCCTCACCGGCCACCTGAGGACGCACTCCGTTGGTAAGCCTCAC","Yes",{"$nulls":12},"Embryonic lethal E15.5-17.5AnemiaFailure of normal erythroblast growth and differentiation in fetal liverExpansion of myeloid cells including: CD34⁺CD45⁺FcγR⁺ and Mac-1hi and Gr-1lo cell populationsNo detectable Gr-1hi cellsEarly lymphocyte development arrestAccumulation of precursor B cells in thymus at expense of T cell developmentPremature down regulation of c-kit expressionCell intrinsic defectFetal liver cells fail to engraft","T cell Lymphoma, arrested at DN (pro-T3) stage orLymphoblastic lymphoma/leukaemia (pre-T-LBL)","C57BL/6JSfdAnu","No","No","Yes","No","No","Yes","Yes","Good",null,"7",null,"No","2005-11-25","Cryopreserved sperm"]
[4512,"bata ;ENU8B6:058","C57BL/6JSfdAnu-Pnp<bata>/AnuApb",null,"Recessive","purine-nucleoside phosphorylase","Pnp",null,"Np, Np-1, Np-2, Pnp, Pnp1","MGI:97365","bata","Pnp<bata>","MGI:5468722","14","ENSMUSG00000021871","ENSMUST00000048615","Pnp-001","644","925","A to T","ENSMUSE00000617134","5","215","Aspartic acid to Valine",{"$nulls":4},"GAGTCGTCTGCTAAAGATGCTGGGGGCAGATGCTGTTGGCATGAGCACAGTCCCAGAAGTT","Yes",{"$nulls":12},"Decreased anti-IgM B cell proliferation in vitro, age-dependent increase in CD44hi ICOShi CD4 cells and decrease in marginal zone B cells.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[4,"San Roque","C57BL/6JSfdAnu-Rc3h1<san>/AnuApb ","C57BL/6JSfdAnu-Rc3h1<san>/AnuApb","Recessive","RING CCCH (C3H) domains 1","Rc3h1","Unknown","Roquin","MGI:2685397","sanroque","Rc3h1<san>","MGI:3581675","1","ENSMUSG00000040423","ENSMUST00000035911","Rc3h1-201","596","981","T to G","ENSMUSE00000536751","5","199","Methionine to Arginine",{"$nulls":4},"TAGGGGCTGCCAGTTCCTTGGACCAGCGATGCAGGAGGAAGCTCTGAAGCTGGTCTTGCTG","Yes",{"$nulls":12},"Spontaneous autoimmune disease. Systemic lupus erythematosus. Anti-nuclear autoantibodies (ANA), hypergammaglobulinemia, autoimmune nephritis, lymphadenopathy, increased numbers of CD44high activated memory T cells, increased numbers of T follicular helper cells, spontaneous germinal centres, CD28-independent activation of T cells. Increased ICOS mRNA and protein expression on T cells, defect in micro-RNA (mir) inhibition of mRNA stability.","Low penetrance in hets","C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2005-11-28","Cryopreserved sperm"]
[8736,null,"ASD1005:Polenta",null,"Recessive",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2019-06-19","Cryopreserved sperm"]
[4505,"Duane ; ENU6NIHB:019","C57BL/6JSfdAnu-Tbx21<duane>/AnuApb","C57BL/6JSfdAnu-Tbx21<duane>/AnuApb","Recessive","T-box 21","Tbx21","Reduced","T-bet, Tblym, TBT1","MGI:1888984","T-box 21; Duane","Tbx21<duane>","MGI:4367995","11","ENSMUSG00000001444","ENSMUST00000001484","Tbx21-001",{"$nulls":7},"96962921","2",null,null,"CTGGTCGATACTTGACAATAAGGTTAACTGTCCACAGGGAACCGCTTATATGTCCACCCA","Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. Few circulating NK cells.Decreased NK cell number: the percent of NK cells in the blood, spleen, and liver is lower than in wild-type mice.Increased NK cell number:* the frequency of NK cells in the peripheral lymph nodes and bone marrow is increased compared to in wild-type mice.* NK cells accumulate in lymph nodes due to defective egression.Absent NK T cells: mice exhibit a near complete absence of invariant natural killer T cells unlike in wild-type mice.Abnormal NK cell differentiation:* NK cells exhibit an immature phenotype unlike in wild-type mice.* NK cells accumulate in lymph nodes due to defective egression.* in reconstitution experiments, derived NK cells accumulate in the peripheral lymph nodes due to defective egression.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm"]
[123,"CD40L -/- TCR","B10JAnu.Cg-H2<k2> Cd40lg<tm1Flv> Tg(TcrHEL3A9)1Mmd/AnuApb","B10JAnu.Cg-H2<k2> Cd40lg<tm1Flv> Tg(TcrHEL3A9)1Mmd/AnuApb","Recessive","CD40 ligand","Cd40lg","Nil","CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5","MGI:88337","targeted mutation 1, Richard A Flavell","Cd40lg<tm1Flv>","MGI:2182733","X",{"$nulls":15},"No","transgene insertion 1, Mark M Davis","TCR",{"$nulls":10},"Homozygous mice display: - immune system, lymphoid development/B lymphocyte defects: -  B cells failed to undergo isotype switching -  failed to produce germinal centers in spleen in response to T-dependent antigens -  reduced serum immunoglobulin concentrations (IgG1, IgG2a, IgG2b, IgG3), at 12 weeks of age, but not at 6 weeks of age -  decreased IgM response to T-dependent antigens -  failed to produce antigen-specific IgG1 after immunization -  immune system, no defect detected: -  no alterations in B or T lymphocyte development -  T lymphocytes responded normally to mitogen stimulation -  B lymphocytes had normal responses to T-independent antigens",null,"C57BL/10J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16",null,"No","2006-02-06","Cryopreserved sperm"]
[126,"Charles ; ML5","C57BL/6JSfdAnu-Tg(ML5sHEL)5Ccg/AnuApb","C57BL/6JSfdAnu-Tg(ML5sHEL)5Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 5, Christopher C Goodnow","metallothionein I","high",{"$nulls":9},"Mice express a soluble form of hen egg lysozyme, levels are higher than similar strain C57BL/6-Tg(ML4sHEL)5Ccg/J.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"22","sib x sib","No","2006-02-06","Cryopreserved sperm"]
[117,"Carrie ; GM2","C57BL/6JSfdAnu-Tg(IghelMG)Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IghelMG)Ccg/AnuApb","Dominant",{"$nulls":25},"Low copy number (3H, 1L) anti-HEL transgenic for a chimeric Ig protein (IgM extracellular, and IgG transmembrane and intracellular domains)",null,"low",{"$nulls":9},"B cells express immunoglobulin specific for Hen Egg Lysozyme.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"21","Ig+ male x B6 female","No","2006-02-06","Cryopreserved sperm"]
[138,"Mev:Hamlet","C57BL/6JSfdAnu-Ptpn6<me-v> Tg(IghelMD4)4Ccg/AnuApb","C57BL/6JSfdAnu-Ptpn6<me-v> Tg(IghelMD4)4Ccg/AnuApb","Recessive","protein tyrosine phosphatase, non-receptor type 6","Ptpn6","Nil","hcp, Hcph, Ptp1C, SHP-1, Spin","MGI:96055","viable motheaten","Ptpn6<me-v>","MGI:1856074","6",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow ",null,"Low",{"$nulls":11},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5",null,"No","2006-02-06","Cryopreserved sperm"]
[132,"Hamlet ; MD4","C57BL/6JSfdAnu-Tg(IghelMD4)4Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IghelMD4)4Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"low copy number",{"$nulls":9},"Bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background. Transgenic mice, more than 90% of B-cells in the spleen are derived from the transgene (a allotype) and are predominantly IgM and IgD. There is a moderate reduction in B cell frequency and number in spleen and lymph node. B cells did not express Ly-1 or Mac-1. The Ig phenotype of splenic B cells in adult mice (IgMhiIgDlo-hi) resembled that of splenic B cells in non-transgenic 1 - 2-week-old mice.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"17",null,"No","2006-02-06","Cryopreserved sperm"]
[8724,"Adar1E861A/E861A Ifih1-/- Adar2-/- Gria2R/R","B6.129-Adar<tm1.1Xen> Adarb1<tm1PhS> Gria2<tm1Phs> Ifih1<tm1.1Cln>/StVApb",null,"Recessive","interferon induced with helicase C domain 1","Ifih1",null,"9130009C22Rik, Helicard, MDA5, MDA-5","MGI:1918836","interferon induced with helicase C domain 1; targeted mutation 1.1, Marco Colonna","Ifih1<tm1.1Cln>","MGI:3663677","2"]
[164,"C2NX1f","129/Sv-Cited2<tm1Dunw>/Apb","129/Sv-Cited2<tm1Dunw>/Apb","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Unknown","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1, Sally L Dunwoodie","Cited2<tm1Dunw>","MGI:3696061","10",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for the conditional allele of Cited2 are viable and no phenotype has been observed.","No Phenotype","129S1/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3","0","Heterozygous mice are backcrossed into 129X1/SvJ to increase health as ES origin is not as viable","No","2006-04-15","Cryopreserved sperm"]
[267,"B6.gA-/-","C57BL/6-Gzma<tm1Simn>/AnuApb",null,"Recessive","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"No",{"$nulls":12},"Tumorigenesis * homozygotes control growth of syngeneic tumors (s.c. inoculation of H-2b MC57G fibrosarcoma) as efficiently as wild-type miceHematopoietic system phenotype * homozygotes are viable, fertile, and display normal hematopoiesis relative to wild-type mice* in mutant spleens, the numbers of CD4+ and CD8+ T cells, macrophages, NK cells and B cells fall within normal ranges* the frequencies of CD4+ and CD8+ T cells responding to H-2 alloantigens in primary mixed lymphocyte cultures (MLC) with proliferation are also within normal rangesImmune system phenotype* in vitro- and ex vivo-derived cytotoxic T cells and NK cells from mutant mice induce specific target cell membrane disruption, DNA fragmentation, and apoptosis as efficiently as wild-type cells * homozygotes control infections with lymphocytic choriomeningitis (LCM) virus and L. monocytogenes as efficiently as wild-type mice * homozygotes develop a normal contact hypersensitivity (CHS) response (based on increase in ear thickness) to trinitrophenyl (TNP) relative to wild-type mice ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-30","Cryopreserved sperm"]
[341,"EphA1-/- hPLAP","B6;129-Epha1<tm1Sld>/Apb","B6;129-Epha1<tm1Sld>/Apb","Recessive","Eph receptor A1","Epha1","Nil","5730453L17Rik, Eph, Esk","MGI:107381","targeted mutation 1, Shannon L Duffy","Epha1<tm1Sld>","MGI:3822370","6",{"$nulls":15},"Yes","internal ribosome entry site - human placental alkaline phosphatase","endogenous EphA1","Restricted to epithelial tissue",{"$nulls":9},"Vaginal inflammation:mice exhibit inflammation of the vaginal mucosa secondary to hydrometrocolpos.Endometrium inflammation:mice exhibit endometrium inflammation secondary to hydrometrocolpos.Dilated uterine horn:mice exhibit dilated, attenuated uterine horns secondary to hydrometrocolposEnlarged uterus:mice exhibit an enlarged uterus due to an accumulation of clear uterine fluid (hydrometrocolpos).Increased uterus weight:Vagina atresia:18% of mice exhibit a failure of vaginal openingdespite normal estrogen receptor expression, beta-estradiol treatment fails to induce precocious vaginal opening in P12 mice unlike in wild-type mice and vaginal opening can not be induced by likewise treating affected adult mice.Hydrometrocolpos:mice exhibit inflammation of the vaginal mucosa and endometrium with dilated, attenuated uterine horns secondary to hydrometrocolposFemale infertility:female mice affected by hydrometrocolpos are sterileKinked tail:up to 80% of mice exhibit a kinky tail due to incorrectly positioned caudal vertebraeDistended abdomen:in some mice due to an enlarged uterusAbnormal response/metabolism to endogenous compounds:treatment with beta-estradiol fails to induce apoptosis in the lower genital tract and precocious vaginal opening unlike in wild-type mice.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3","5","Homozygous knockout crossed with homozygous knockout or C57BL/6 wildtype","No","2006-09-22","Cryopreserved sperm"]
[345,"Human GM-CSF","NOD.Cg-Prkdc<scid> Tg(hGM-CSF)8KHsr/Apb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc",null,"DNAPDcs, DNA-PK, DNA-PKcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"No","human granulocyte-macrophage colony stimulating factor ","murine T Cell Receptor (TCR) enhancer and H2-K<b> promoter","High",{"$nulls":9},"Unable to maintain colony in homozygous state","Normal","NOD/SCID","Yes","No","Yes","Yes","No","Yes","No","Excellent","20","0","Purchased NOD/SCID mated with transgenic mouse from colony to maintain colony","No","2006-09-25","Cryopreserved sperm"]
[282,null,"129/Sv-Ifngr<tm1Agt>/Apb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, Ifngr, INF-g receptor, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"abnormal immunoglobulin level:levels of IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virusincreased susceptibility to viral infection:slightly more susceptible to MCMV viral infection than controls increased susceptibility to Ectromelia virus 100% mortality by day 6-12 after primary infection infectionelevated virus titers in all organs tested after primary infection but much improved after secondary infectionssurvive secondary infections ",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-02","Cryopreserved sperm"]
[1494,"B6.C1q-/-","B6;129S-C1qa<tm1Mjw>/Apb","B6;129S-C1qa<tm1Mjw>/Apb","Recessive","complement component 1, q subcomponent, alpha polypeptide","C1qa","Nil","C1q","MGI:88223","complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport","C1qa<tm1Mjw>","MGI:2158701","4",{"$nulls":15},"No",{"$nulls":12},"Premature death: 15% die at 4 - 6 months of ageIncreased anti-nuclear antigen antibody level:* mutants develop high titers of anti-nuclear antibodiesIncreased anti-histone antibody level.Glomerulonephritis:* Background Sensitivity: severe proliferative crescentic glomerulonephritis evident in 27% mice.* Background Sensitivity: striking feature is presence of multiple apoptotic bodies in diseased glomeruli.* among mutants without glomerulonephritis, significantly greater numbers of glomerular apoptotic bodies are seen than in controls.Increased susceptibility to bacterial infection:* animals challenged with virulent pneumococci develop bacteremia and pneumonia after passive immunization with human IgG1 or human IgG2 unlike wild-type mice that are protected after immunization.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-03","Cryopreserved sperm"]
[631,"Pkr KO","B6;129-Eif2ak2<tm1Cwe>/Apb","B6;129-Eif2ak2<tm1Cwe>/Apb","Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Nil","dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, Eif2ak2, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449","targeted mutation 1, Charles Weissmann","Eif2ak2<tm1Cwe>","MGI:2182566","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.  Enlarged lymph nodes. Altered susceptibility to viral infection.increased T cell proliferation.Proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increasedabnormal inflammatory mediator physiology.A 2 fold increase in Il4 production by CD44+ cellsincreased susceptibility to viral infection.Susceptibility to encephalomyocarditis virus testedresponse to infection and survival were similar to control mice; however, pretreatment of mice with IFNgamma failed to improve survival as it did in controlsincreased susceptibility to type IV hypersensitivity reaction. Exaggerated response to challenge after presensitization in contact hypersensitivity testeffect can be transferred to naive mice using CD8+ cells from sensitized mice.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent",null,null,"Hom x Hom","No","2007-04-25","Cryopreserved sperm"]
[633,"Elvis","NOD.129-Tg(Csf2rb<WT>) Csf2rb1<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc",null,"DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16"]
[8740,"ASD977:Zambrero:6","C57BL/6NCrlAnu-Ryr2<em2Anu>/AnuApb",null,"Recessive","ryanodine receptor 2, cardiac","Ryr2","Unknown","9330127I20Rik","MGI:99685",{"$nulls":3},"13",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-28","Cryopreserved sperm"]
[696,"PrlΔ","STOCK Prl<tm1Hmn>/Apb","STOCK Prl<tm1Hmn>/Apb","Recessive","prolactin","Prl","Nil","Prl, Prl1a1","MGI:97762","targeted mutation 1, Nelson D Horseman","Prl<tm1Hmn>","MGI:1934021","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.Abnormal branching of the mammary ductal tree:* ductal system comprises an extended branching network but devoid of terminal and lateral lobulationDecreased prolactin level: * in the pituitaryDecreased circulating prolactin level Failure of embryo implantation Abnormal mammary gland morphology Abnormal branching of the mammary ductal tree:* ductal system comprises an extended branching network but devoid of terminal and lateral lobulationAbnormal estrous cycle: * a consistent pattern of cycling was not established.",null,"Unknown","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",null,null,"HET x HET to maintain colony, KO male x HET female to produce more KOs","No","2007-05-01","Cryopreserved sperm"]
[1514,"eNOS -/-","B6.129S4-Nos3<tm1Plh>/AnuApb","B6.129S4-Nos3<tm1Plh>/AnuApb","Recessive","nitric oxide synthase 3, endothelial cell","Nos3","Nil","2310065A03Rik, ecNOS, eNOS, Nos-3","MGI:97362","targeted mutation 1, Paul L Huang","Nos3<tm1Plh>","MGI:2150145","5",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit reduced survival, hypertension, inhibited basal vasodilation, insulin resistance, fewer mitochondria, reduced heart rate, impaired ovulation and, in some, shortened limbs.          ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2007-07-04","Cryopreserved sperm"]
[8744,"ASD572:Shn-2 KO:AIRE KO","B6.Cg-Aire<tm1Pltn> Hivep2<tm1Sis>/AnuApb",null,"Recessive","human immunodeficiency virus type I enhancer binding protein 2","Hivep2","Nil","Gm20114, MIBP1, Schnurri-2, Shn-2","MGI:1338076","human immunodeficiency virus type I enhancer binding protein 2; targeted mutation 1, Shunsuke Ishii","Hivep2<tm1Sis>","MGI:2182914","10"]
[1601,"GAD67-GFP","C57BL/6-Gad1<tm1Tama>/AnuApb",null,"Dominant","glutamic acid decarboxylase 1","Gad1","Normal","EP10, Gad-1, GAD67, Z49976","MGI:95632","targeted mutation 1, Nobuaki Tamamaki","Gad1<tm1Tama>","MGI:3590300","2",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal involuntary movement:*at E14, the frequency of mouth opening and tongue withdrawal are reduced compared to wild type littermates.Abnormal nervous system electrophysiology:* at E14 the frequency of neural discharges from the hypoglossal nerve and C4 ventral root that stimulate muscle activity in the neck and tongue is reduced however the amplitude of these discharges is similar to wild type.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-11","Cryopreserved sperm"]
[1626,"C2X1f","129X1;129S1-Cited2<tm1.1Dunw>/Apb","129X1;129S1-Cited2<tm1.1Dunw>/Apb","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Normal","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1.1, Sally L Dunwoodie","Cited2<tm1.1Dunw>","MGI:3696062","10",{"$nulls":15},"No",{"$nulls":12},"Normal","None","129X1/SvJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3","0","Backcrossed into 129X1/SvJ to increase health as ES origin is not as viable.","No","2007-07-16","Cryopreserved sperm"]
[8746,"ASD873:Pear:XB3bpins","C57BL/6NCrlAnu-Xbp1<em2Anu>/AnuApb",null,"Recessive","X-box binding protein 1","Xbp1","Unknown","D11Ertd39e, TREB5, TREB-5, XBP-1","MGI:98970",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-02","Cryopreserved sperm"]
[2397,"Zap70 knockout","B6;129X1-Zap70<tm1Weis>/AnuApb","B6;129X1-Zap70<tm1Weis>/AnuApb","Recessive","zeta-chain (TCR) associated protein kinase","Zap70","Nil","Srk, TZK, ZAP-70","MGI:99613","targeted mutation 1, Arthur Weiss","Zap70<tm1Weis>","MGI:2176252","1",{"$nulls":15},"No",{"$nulls":12},"Abnormal T cell differentiation:* the number of dendritic epidermal T cells is reduced and those cells present lack the characteristic dendritic extensions.* few intestinal intraepithelial lymphocytes express gamma delta or alpha beta T cell receptors.Arrested T cell differentiation: arrest at the double positive stageAbnormal splenic cell ratio: spleens are composed of mostly B cells.Abnormal lymph node cell ratio:* lymph nodes contain mostly B cells and a significant percentage of CD3+ (but CD4- and CD8-) cells which are primarily gamma delta T cells.* the percentage of gamma delta T cells is increased but the absolute number of these cell is similar to wild-type.",null,"C57BL/6 x 129X1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-20","Cryopreserved sperm"]
[8747,"ASD960:Orange:XB131","C57BL/6NCrlAnu-Xbp1<em3Anu>/AnuApb",null,"Recessive","X-box binding protein 1","Xbp1","Unknown","D11Ertd39e, TREB5, TREB-5, XBP-1","MGI:98970",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-02","Cryopreserved sperm"]
[5431,"Funky","STOCK Ndufs4<fky>/DrthApb","STOCK-Ndufs4<fky>/Drth","Recessive","NADH dehydrogenase (ubiquinone) Fe-S protein 4","Ndufs4","Reduced","C1-18k","MGI:1343135","funky","Ndufs4<fky>","MGI:4942335","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mice initially present with fur loss around postnatal day 14, which regrows in the next hair cycle. They show reduced growth and several behavioural abnormalities that appear from postnatal week five, such as tilting of the head, walking in circles and twisting of the body when suspended by the tail. Due to progressively wobbly gait and general deterioration in physical condition, all homozygous mice have to be euthanased around postnatal week eight in compliance with ethical guidelines.","Appears indistinguishable from Wild-Type","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Poor","unknown",null,"het X het","No","2011-02-14","Cryopreserved sperm"]
[2398,"Activin Beta C ++ FL2","C57BL/6-Tg(ACTIVIN-β{C})2Grb/Apb",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"No","human activin betaC","CMV","High",{"$nulls":9},"No gross external abnormalities evident, male sub-fertile (narrow window of fertility 7-9 weeks), limited pups resulting from matings, infertile from around 9 weeks.  ","No gross external abnormalities evident, male sub-fertile (window of fertility 7-14 weeks), decreased litter size, infertile from around 15 weeks.  ","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","Yes","Poor",null,null,"Het x Het or Het x WT","No","2007-12-20","Cryopreserved sperm"]
[8749,"Arjuna:TCR:B10:kk","B6.B10-H2<k2>Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",null,"histocompatibility-2, MHC","H2",null,null,"MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17",{"$nulls":3},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-09","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter"]
[2734,"-0.9E3CreERT line 145A","C57BL/6-Tg(Tal1-cre/ERT)145AJame/Apb","C57BL/6-Tg(Tal1-cre/ERT)145AJame/Apb","Semi-dominant",{"$nulls":25},"transgene insertion 145A, J Anke M van Eekelen","-0.9E3 neural enhancer/promoter of the Stem Cell Leukemia (Scl/tal1) gene","Moderate expression of creERT in Scl expressing neurons of the CNS",{"$nulls":9},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"-0.9E3CreERT line 145A x C57BL/6J","No","2008-02-06","Cryopreserved sperm"]
[2772,"BALB/c.Flii<+/+> FLII<c17.8/+> ; FIT","BALB/c-Tg(FLII)2Hdc/AnuApb","BALB/c-Tg(FLII)2Hdc","Dominant",{"$nulls":25},"Human Flightless gene","Human Flightless",{"$nulls":10},"Ubiquitous expression of human Flightless protein",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het x wt BALB/c","No","2008-02-16","Cryopreserved sperm"]
[3324,"TGM2 floxed","B6;129S1-Tgm2<tm1Rmgr>/Apb","B6;129S1-Tgm2<tm1Rmgr>/Apb","Recessive","transglutaminase 2, C polypeptide","Tgm2","Normal","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 1, Robert M Graham","Tgm2<tm1Rmgr>","MGI:3525256","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","129S1/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"Hom x Hom","No","2008-06-15","Cryopreserved sperm"]
[3341,"CBA/Ca Tg(IL5)C1","CBA/Ca-Tg(CD2-Il5)5C1Ldt/Apb [cc]","CBA/Ca-Tg(CD2-Il5)5C1Ldt/Apb [cc]","Recessive",{"$nulls":25},"transgene insertion 5C1, Lindsay A Dent","dominant controlling region (DCR), to approx. 2.1kb, 3' of the genomic sequence of the human CD2 gene","8 copies",{"$nulls":9},"Do not maintain as homozygotes.  While this is apparently possible, survival of homozygotes likely to be lower.","Appear normal with peripheral blood eosinophilia and increased numbers of eosinophils in the spleen (with splenomegaly), bone marrow.Heterozygous BALB/c and C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","CBA/Ca","No","No","Yes","No","No","Yes","No","Excellent",null,null,"Tg male wild type female","No","2008-06-20","Cryopreserved sperm"]
[3926,"K5-crePR1 , K5cre*PR1 ; K5S","BALB/c-Tg(KRT5-cre*/PGR)1Der/AnuApb",null,"Dominant",{"$nulls":25},"Cre recombinase, mutant; Cre* fused to a deletion mutant of the human progesterone receptor (PR)","bovine keratin 5","Normal to high, restricted to keratinocytes",{"$nulls":9},"To activate or inactivate conditional alleles in murine stratified epithelia, a novel system has been developed. It is based on the generation of transgenic mice that express an inducible Cre recombinase under the control of a promoter specific for stratified epithelia. The inducible features of Cre were achieved by fusing Cre to a deletion mutant of the human progesterone receptor (PR), which fails to bind progesterone but can be activated by progesterone antagonists, such as RU486. This fusion protein (CrePR1) is sequestered in the cytoplasm. After activation with RU486, CrePR1 translocates to the nucleus, where it mediates the excision of DNA sequences flanked by LoxP sites. Mice generated express CrePR1 under the control of the K5 which is expressed in the basal cells of stratified epithelia ",null,"Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","4",null,"Backcross to balb/c","No","2008-10-14","Cryopreserved sperm"]
[3392,"C3H.PRI-Flv<r>; C3H/Rv","C3.PRI-Oas1b<Flv-r>/ArcApb","C3.PRI-Oas1b<Flv-r>/ArcApb","Dominant","2'-5' oligoadenylate synthetase 1B","Oas1b","Normal","Flavivirus resistance, Flv, L1, Mmu-L1, Oias-2, Oias2, Wnv","MGI:97430","flavivirus resistance","Oas1b<Flv-r>","MGI:1857800","5",{"$nulls":15},"No",{"$nulls":12},"Decreased susceptibility to viral infection: viral replication was inhibited in mice from resistant strains upon innoculation with the following viruses: Yellow Fever, Dengue Fever, West Nile Fever, Japanese Encephalitis, St. Louis Encephalitis, Russian Spring Summer Encephalities.  Flv<r> Phenotpye:- resistance to infections by Flaviviruses.  Tlr4 Phenotpye:- Toll 4 receptor is responsive to LPS infection.  Diht<high> Phenotpye:- an increased hypothermia response as measured by a drop in core temperature following peripheral administration of a dopamine agonist.","Flv<r> Phenotpye:- dominant phenotype, heterozygotes are resistant to infection.    Tlr4 Phenotpye:- dominant phenotype, heterzygotes show responsiveness to LPS.    Diht<high> Phenotpye:- dominant and dopamine-induced hypothermia in heterozygotes show the high responder phenotype.","C3.PRI.Oas1b<Flv-r>","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"12","brother x sister","No","2008-07-11","Cryopreserved sperm"]
[5435,"Funky","B6.Cg-Ndufs4<fky>/DrthApb","B6.Cg-Ndufs4<fky>/Drth","Recessive","NADH dehydrogenase (ubiquinone) Fe-S protein 4","Ndufs4","Reduced","C1-18k","MGI:1343135","funky","Ndufs4<fky>","MGI:4942335","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mice initially present with fur loss around postnatal day 14, which regrows in the next hair cycle. They show reduced growth and several behavioural abnormalities that appear from postnatal week five, such as tilting of the head, walking in circles and twisting of the body when suspended by the tail. Due to progressively wobbly gait and general deterioration in physical condition, all homozygous mice have to be euthanased around postnatal week eight in compliance with ethical guidelines.","Appears indistinguishable from Wild-Type","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Poor","10",null,"het X het","No","2011-02-15","Cryopreserved sperm"]
[4184,null,"C57BL/6-CD151<floxLka>/Apb",null,"Recessive","CD151 antigen","Cd151","Normal","PETA-3, SFA-1, Tspan24","MGI:1096360",{"$nulls":3},"7",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-12-19","Cryopreserved sperm"]
[8753,"CLDN10 PM","C57BL/6-Cldn10<em1Marp>/MarpApb",null,"Recessive","claudin 10","Cldn10","Unknown","6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e","MGI:1913101",{"$nulls":3},"14",{"$nulls":28},"Affects ion transport in the kidney","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-18"]
[5443,"NODGrzA","NOD.B6-Gzma<tm1Simn>/LtJApb",null,"Dominant","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","granzyme A; targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"No",{"$nulls":12},"Mice are healthy and develop normally, but develop diabetes at a slightly accelerated rate compared to NOD/Lt mice.","Mice are healthy and develop normally, but will develop diabetes similar to NOD/Lt mice.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","11","5","Sister X Brother","Yes","2011-02-23","Cryopreserved sperm"]
[4533,"Drasic -/-","B6.129-Asic3<tm1Wsh>/Apb",null,"Recessive","acid-sensing (proton-gated) ion channel 3","Asic3","Unknown","Accn3, DRASIC","MGI:2159339","acid-sensing (proton-gated) ion channel 3; targeted mutation 1, Michael J Welsh ","Asic3<tm1Wsh>","MGI:2429689","5",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors.  Hyperglasia- at site of injury (carrageenan-induced inflammation), mice showed increased sensitivity to mechanical stimuli, but not to noxious thermal stimulus. Responses to somatosensory stimuli under normal conditions were similar to wild-type littermates",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm"]
[4580,"Gld:kk","B10.BR-H2<k2> Fasl<gld>/JAnuApb",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Unknown","APT1LG1, CD178, CD95L, Fas-L, Tnfsf6","MGI:99255","generalized lymphoproliferative disease","Fasl<gld>","MGI:1856384","1",{"$nulls":15},"Yes",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","homeostasis/metabolismabnormal interleukin level (J:8267)stimulation with concanavalin A does not induce cells to produce Il2immune systemabnormal T cell morphology (J:8267)lymph node cells (T cell origin) are abnormal; cells are Ly-2-/L3T4-/surface Ig-abnormal T cell proliferation (J:8267)cells do not proliferate in response to stimulation with alloantigensabnormal interleukin level (J:8267)stimulation with concanavalin A does not induce cells to produce Il2abnormal T cell physiology (J:8267)cells do not generate CTL in response to stimulation with alloantigens",null,"B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-08","Cryopreserved sperm"]
[4785,"Line3","FVB-Tg(HBA1-GFP)3Ew/Apb",null,"Dominant",null,null,"Increased",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 3, Emma Whitelaw","α-Globin (-570 to +37) (4.1kb of enhancer)","36 copies",{"$nulls":9},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2009-09-06","Cryopreserved sperm"]
[4596,"NOD.scid H-2K<b> homozygous","NOD-Prkdc<scid> Tg(H2K<b>)1Rms/MarpApb",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes","transgene insertion 1, Robyn M Slattery","MHC Class I",{"$nulls":10},"Decreased T and B cells.",null,"NOD-Prkdc<scid>","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm"]
[4778,"Rathbone","C.B6(129)-Ifng<tm1Ts>/AnuApb",null,"Recessive","interferon gamma","Ifng","Nil","Ifg, IFN-gamma","MGI:107656","targeted mutation 1, Timothy Stewart","Ifng<tm1Ts>","MGI:1857184","10",{"$nulls":15},"Yes",{"$nulls":12},"Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another. Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a \"clean\" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.",null,"BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm"]
[4786,"Blades","C.129-IL5<tm1Kopf> Eotaxin<tm1Mer>/AnuApb",null,"Recessive","interleukin 5","Il5","Unknown","Il-5","MGI:96557","targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-09-06","Cryopreserved sperm"]
[4897,"B6-Lym1","B6.C-Nfkb2<Lym1>/SviApb",null,"Recessive","nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100","Nfkb2","Unknown","NF kappaB2, p52","MGI:1099800","Lym1","Lym1",null,"19",{"$nulls":28},"Increased circulating lymphocytes.A comprehensive histopathological analysis of these mice, however, revealed an absence of peripheral LN (inguinal, brachial, axillary, cervical) and Peyer’s patches. Mesenteric LN were present, but were reduced in size and cellularity.presence of inflammatory cell infiltrates in the lung and liver.The number of mature recirculating B cells was significantly reduced.Nfkb2<Lym1/Lym1> bone marrow was almost completely unresponsive to RANKL with osteoclast formation <0.5% of that seen with wt.Mild osteopetrosis, with significantly increased trabecular bone volume","The ability of Nfkb2<Lym1/+> cells to form osteoclasts in response to RANKL stimulation was significantly reduced","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2009-10-09","Cryopreserved sperm"]
[8758,"ASD783:Man2a1:GtoC","C57BL/6NCrlAnu-Man2a1<m2Anu>/AnuApb",null,"Recessive","mannosidase 2, alpha 1","Man2a1",null,"Mana2, Mana-2, Map-2","MGI:104669",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-31","Cryopreserved sperm"]
[8759,"ENU46:072:Casp1","C57BL/6NCrlAnu-Casp1<m3Anu>/AnuApb",null,"Recessive","caspase 1","Casp1","Unknown","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-01","Cryopreserved sperm"]
[4913,"VASP","C57BL/6-Vasp<tm1Mzim>/Apb",null,"Recessive","vasodilator-stimulated phosphoprotein","Vasp","Nil",null,"MGI:109268","targeted mutation 1, Michael Zimmer","Vasp<tm1Mzim>","MGI:1858032","7",{"$nulls":28},"Haematopoietic system phenotype:homozygotes show no differences in platelet number in total blood and platelet-rich plasma relative to wild-type littermatesIncreased megakaryocyte cell number:homozygotes display a moderate megakaryocyte hyperplasia in bone marrow and spleenAbnormal platelet activation:upon stimulation of platelet-rich plasma with 0.5 units/ml of thrombin, mutant platelets show a 2-fold increase in surface expression of P-selectin and fibrinogen binding relative to wild-type platelets, indicating enhanced agonist-induced platelet activation.unexpectedly, preincubation with the cAMP-elevating prostaglandin E1 completely abolished thrombin-induced fibrinogen binding and P-selectin expression, as well as platelet aggregation, in both wild-type and homozygous mutant platelets.",null,"C57BL/6`","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom, Hom x Het","No","2009-10-16","Cryopreserved sperm"]
[4921,"Kinks","NOD.129/Sv-Tg(Csf2rb<AAA>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15"]
[5042,"PRlacZ","B6.129S7/SvEvBrd-Pgr<tm1Lyd>/Apb",null,"Recessive","progesterone receptor","Pgr","Unknown","NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 1, John P Lydon","Pgr<tm1Lyd>","MGI:3032652","9",{"$nulls":15},"No",{"$nulls":12},"Abnormal sexual interaction: females did not exhibit sexual behavior.Abnormal female reproductive system morphology.Abnormal mammary gland development.Absent corpus luteum.Uterus hyperplasia.Abnormal reproductive system physiology.Abnormal ovulation: ovulation could not be stimulated with exogenous hormones.Female infertility.","Normal","129S7/SvEvBrd x C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm"]
[4961,"B6 Stat6-/- N10","B6(Cg)-Stat6<tm1Aki>/AnuApb",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Nil","stat6-","MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No",{"$nulls":12},"Skin inflammation:* mice exhibit mild dermal infiltration of inflammatory cells.* few CD4+ cells infiltrate the perioral dermis and epidermis.Acanthosis: sight.Decreased B cell proliferation:* B cell proliferation in response to anti-IgM plus IL-4 is impaired.* however, B cell proliferation in response to LPS is normal.Decreased T cell proliferation:* thymocyte proliferation in response to TPA is impaired.* however, thymocyte proliferate in response to other stimuli.Decreased IgE level: IgE levels are lower than in wild-type mice following infection with N. brasiliensis.Decreased IgG1 level: IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice.Increased IgA level: IgA levels are slightly increased following infection with N. brasiliensis.Increased IgG level: IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis.Abnormal T-helper 2 physiology: mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis.",null,"C57BL/6 x BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-13","Cryopreserved sperm"]
[4966,"pGL3(-1501bp)CYP27B1 promotor-luciferase reporter","B6;CBA-Tg(Cyp27B1-Luc)/Apb",null,"Dominant",{"$nulls":25},"luciferase","1.5kb human CYP27B1",{"$nulls":10},"Strain not maintained in homozygous state","Luciferase activity are observed in a variety of tissues which is driven by the human 1501 bp CYP27B1 flanking sequence. The level of luciferase activity can vary depending on age and treatment. No other phenotype is observed.","CBA x C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Het x WT","No","2010-01-15","Cryopreserved sperm"]
[4990,"EPO IL5tg1","C.129/Ola-Epx<tm1Nal> Tg(CD2-IL5)5C2Ldt/AnuApb",null,"Dominant","eosinophil peroxidase","Epx","Nil","EPO","MGI:107569","eosinophil peroxidase; targeted mutation 1, Nancy A Lee","Epx<tm1Nal>","MGI:2182952","11",{"$nulls":15},"Yes","transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia.    Northern blotanalysis identified 11,5 mRNA in the thymus, Peyer's patches, and subcutaneous (pooled inguinal and axillary) lymph nodes. No IL5 mRNA was detected in liver, heart, brain, or skeletal muscle tissues from transgenics, nor in any tissues from normal littermates.   Do not maintain as homozygotes.  While this is apparently possible, survival of homozygotes likely to be lower.","Appear normal with peripheral blood eosinophilia and increased numbers of eosinophils in the spleen (with splenomegaly), bone marrow.  Heterozygous BALB/c and C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","BALB/c x 129","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm"]
[5137,"A7","C57BL/6-Tg(Tcra149.42)Cbn/JWehiApb",null,"Dominant",{"$nulls":25},"transgene insertion Tcra149.42, Francis R Carbone","H-2Kb",{"$nulls":10},"Homozygous mice exhibit an increased incidence of seizures so mice are maintained as heterozygous.","The majority of CD8 T cells express the trangenic Va2 T cell receptor.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"greater than 30","brother-sister","No","2010-05-26","Cryopreserved sperm"]
[5131,"Delta 358 ; Tie2DeltaCx40.358","B6;CBA-Tg(Tie2-Gja5<DN358>)/AnuApb",null,"Dominant","gap junction protein, alpha 5","Gja5","Increased","connexin 40, Cx40, Gja-5","MGI:95716",{"$nulls":3},"Unknown",{"$nulls":16},"dominant negative of Cx40","Tie2 endothelial specific",{"$nulls":10},"Unknown","Mild Hypertension","N3 B6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","2",null,null,"No","2010-05-24","Cryopreserved sperm"]
[5146,"Aire KO","B6.129-Aire<tm1Pltn>/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Pltn>","MGI:2182940","10",{"$nulls":15},"No",{"$nulls":12},"Targeted mutations that inactivate the gene result in immune system dysfunction characterized by multiorgan lymphocytic infiltration and circulating autoantibodies.Absent adrenal gland: absence of the adrenal glands is seen with incomplete penetrance; however, the thyroid and pancreas are normal.Abnormal T cell morphology: the TCR-Vbeta repertoire is altered in peripheral T cells.Increased T cell proliferation: immunization with hen egg lysozyme antigen results in a 4-5-fold increase in proliferating response of peripheral T cells, with mutants showing twice as many T cells in the lymph nodes than controls.Thymus atrophy: thymic atrophy is seen in 2 of 14 mutants.Increased autoantibody level: 73% of homozygous mice generated autoantibodies against at least one of the organs (liver, testis, pancreas and adrenal gland) tested and 40% of mice contain autoantibodies against two or more of the organs.Liver inflammation: 50% of mutants exhibit accumulation of lymphocytes in periportal regions.Infertility: 85% of male or female mutants fail to produce any litters.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2010-06-02","Cryopreserved sperm"]
[5165,"WA2","NOD/Lt-Idd11<Idd11C57BL/6WA>/ArcApb",null,"Dominant",{"$nulls":37},"As per background strain.This mouse model appears to get diabetes earlier than the NOD/Lt mouse that is the background of the WA2 strain. Given we have introduced C57BL/6 mouse region into the NOD/Lt we expected to see a protection against T1D in this strain. So we feel this strain is very helpful in understanding the epigenetic effect of Type 1 Diabetes. It appears it is not enough to change the gene locus involved in T1D, but there are other factor affecting the C57BL/6 genes we have introduced. We believe that the same genes in the NOD/Lt strain now behave differently when there is a C57BL/6 stretch of DNA in a small region of Chromosome 4.","As per background strain.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Hom x Hom","No","2010-06-29","Embryo"]
[5168,"Idd5C","NOD.B6-Idd5C<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":37},"As per the parental strain (NOD/Lt).Type I diabetes onset same as NOD/Lt.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2010-06-29","Embryo"]
[6635,"Cd11c-DTR/EGFP","C.FVB-Tg(Itgax-DTR/EGFP)57Lan/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 57, Richard A Lang","mouse Itgax promoter (CD11c)",{"$nulls":10},"Immune system phenotype: conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin.Decreased dendritic cell number: 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells.Decreased circulating interferon-gamma level: following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin.Decreased circulating interleukin-12 level: following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin.Abnormal NK cell physiology: following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin.Decreased interferon-gamma secretion: following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20","Cryopreserved sperm"]
[6764,"gp130/Stat3 (BJ-13)","STOCK Il6st<tm1Ern> Stat3<tm1Aki>/LudApb",null,"Recessive","signal transducer and activator of transcription 3","Stat3","Nil","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 1, Shizuo Akira","Stat3<tm1Aki>","MGI:1926814","11"]
[5229,"Ripk2tm1Flv","C57BL/6-Ripk2<tm1Flv>/Apb",null,"Recessive","receptor (TNFRSF)-interacting serine-threonine kinase 2","Ripk2",null,"CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2","MGI:1891456","receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Richard A Flavell","Ripk2<tm1Flv>","MGI:2660793","4",{"$nulls":15},"No",{"$nulls":12},"Abnormal macrophage physiology:        * bone marrow derived macrophages produce less IL-6 and TNF when cultured in the presence of L. monocytogenes        * in macrophages pre-treated with TLR ligands (i.e. \"tolerized\"), macrophages produce significantly less inflammatory cytokines upon incubation with L. monocytogenes than controls that were LPS pre-treatedDecreased interleukin-6 secretion:        * bone marrow derived macrophages secrete half the amount of IL-6 as wild-type controls in response to culturing with L. monocytogenes        * IL-6 secretion is 22% that of controls when macrophages are pre-treated with LPS prior to L. monocytogenes incubation        * bone marrow derived macrophages fail to produce IL-6 when pre-treated with LPS prior to NOD2 stimulationDecreased tumor necrosis factor secretion:        * bone marrow derived macrophages secrete 61% TNF as wild-type controls in response to culturing with L. monocytogenes        * IL-6 secretion is about 20% that of controls when macrophages are pre-treated with LPS or LTA prior to L. monocytogenes incubation        * bone marrow derived macrophages fail to produce TNF when pre-treated with LPS prior to NOD2 stimulation","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-05","Cryopreserved sperm"]
[8770,"F9 human KI, mouse KO (165B) ","C57BL/6-F9<tm1(F9)Csl>/165BCslApb",null,"Recessive","coagulation factor IX","F9",null,"Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm"]
[7691,"zDC-DTR","B6(Cg)-Zbtb46<tm1(HBEGF)Mnz>/JAusb",null,"Recessive","zinc finger and BTB domain containing 46","Zbtb46",null,"2610019F01Rik, 4933406L05Rik, Btbd4","MGI:1919397","zinc finger and BTB domain containing 46; targeted mutation 1, Michel C Nussenzweig","Zbtb46<tm1(HBEGF)Mnz>","MGI:5444842","2",{"$nulls":29},"Immune system phenotype:Normal:• diphtheria-treated bone marrow chimeras exhibit normal numbers of NK cells and splenic red pulp macrophages• diphtheria toxin-treated chimeras infected with L. monocytogenes exhibit normal numbers of activated monocytes compared with control mice• diphtheria-treated mice exhibit normal numbers of F4/80+ red pulp macrophages, CD169+ marginal zone macrophages and lymph node subscapular sinus macrophagesDecreased dendritic cell number:• absence of classical dendritic cells in diphtheria toxin-treated bone marrow chimeras• partial loss of CD11chiMHCII+ dendritic cells of the small intestine lamina propria of diphtheria toxin-treated bone marrow chimeras• reduced Lin-CD11chi classical dendritic cells in diphtheria-treated T. gondii-infected bone marrow chimeras• however, plasmacytoid cell numbers are normal in diphtheria toxin-treated bone marrow chimerasIncreased monocyte cell number:• small increase in diphtheria toxin-treated bone marrow chimerasincreased neutrophil cell number• diphtheria toxin-treated bone marrow chimeras exhibit increased numbers of splenic Ly6G+ neutrophils compared with controlsabnormal T-helper 1 physiology• reduced IFNgamma+ CD3+CD4+ T cells in diphtheria toxin-treated bone marrow chimeras immunized with either alpha-DEC-205-GAGp24 or alpha-Treml4-GAGp24, or infected with T. gondiiabnormal memory T cell physiology• diphtheria toxin-treated bone marrow chimeras exhibit reduced antitumor memory response compared with control mice that is not as severe as in Tg(Itgax-DTR/EGFP)57Lan hemizygotesAbnormal response to infection:• diphtheria toxin-treated chimeras infected with L. monocytogenes exhibit fewer activated monocytes compared with control mice• mice treated with diphtheria toxin and LPS fail to accumulate CD11c+MHCII+CD14+DEC-205- and CD11c+MHCII+DC-SIGN/CD209+CD14+ cells in the skin lymph nodes unlike control mice• however, diphtheria toxin-treated chimeras infected with L. monocytogenes exhibit normal numbers of activated monocytes compared with control miceIncreased susceptibility to parasitic infection:• diphtheria toxin-treated mice infected with T. gondii exhibit decreased IFNgamma+ CD3+CD4+ T cells and increased parasitic burden compared with controls that is not as severe as in Tg(Itgax-DTR/EGFP)57Lan hemizygotes.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-05-22"]
[7028,"MKB ; Met-Kb","STOCK-Aire<tm1Ptsn> Tg(sMt1-H2-K<b>)/ArcApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire",null,null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Part Peterson","Aire<tm1Ptsn>","MGI:3722595","10",{"$nulls":16},"mouse H2-K<b> (MHC class I)","Sheep metallothionein promoter","variable and slightly lower than wild type H2-K<b>. Expression can be induced with Zinc",{"$nulls":9},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"Yes","2012-07-25","Cryopreserved sperm"]
[8773,"F9 human KI, mouse KO (195B)","C57BL/6-F9<tm1(F9)Csl>/195BCslApb",null,"Recessive","coagulation factor IX","F9","Nil","Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm"]
[298,null,"129P1/ReJ-Lama2<dy>",null,"Recessive","laminin, alpha 2","Lama2","Unknown","mer, merosin, nmf417","MGI:99912","dystrophia muscularis","Lama2<dy>","MGI:1856026","10",{"$nulls":15},"No",{"$nulls":12},"This mutation arose spontaneously in the 129/Re inbred strain at The Jackson Laboratory in 1951. Homozygotes are deficient in merosin (J:18187). Partial restoration of the ability to express Lama2 can be achieved by transplantation of a primary muscle cell culture (J:32227). Lama2dy homozygotes are characterized by progressive weakness and paralysis beginning at about 3 1/2 weeks of age. The hindlimbs are affected first, later the axial and forelimb musculature. Death usually occurs before 6 months of age, and the mice are usually sterile (J:13125). Skeletal muscle shows degenerative changes with proliferation of sarcolemmal nuclei, increase in amount of interstitial tissue, and size variation among individual muscle fibers (J:13125). In the dorsal and ventral roots of the peripheral nerves, both spinal and cranial, Schwann cells fail to separate and ensheathe axons so that groups of closely apposed naked axons, normally seen only in early stages, persist into adulthood (J:5331). At birth there is a deficiency of Schwann cells in the spinal roots, but many undifferentiated cells are present which are probably uncommitted Schwann cells that can differentiate when transplanted to a normal environment (J:12727). In the rest of the peripheral nervous system, the basement membrane of Schwann cells is interrupted by gaps (J:5565), the internodal gap in the nodes of Ranvier is lengthened (J:5866, J:6188), and there is delayed onset of myelination with fewer myelinated axons and shorter internode length (J:12730). There is reduced conduction velocity in spinal roots and peripheral nerves (J:5948) and evidence of defective axonal transport in the sciatic nerve (J:5709, J:5906). It is probable that the myelination defects of the peripheral nerves are due to an intrinsic defect in the dystrophic Schwann cells but the evidence from transplantation experiments, chimeras, and cell cultures is somewhat conflicting (J:30709, J:5580, J:5904, J:7618). There is some evidence for defective myelination in the central nervous system also (J:7911). In culture, myogenic cells from homozygous Lama2dy mice develop muscle properties just as well as cells from control mice (J:5909) and there is no peripheral block of neuromuscular transmission (J:5851, J:5922). Muscle of Lama2dy homozygous mice transplanted into normal hosts is indistinguishable from transplanted control muscle by 100 days (J:8221). There is an extensive literature on morphological and biochemical defects in Lama2dy/Lama2dy muscle.",null,"129","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03"]
[822,"CD40L KO","B6.129-Cd40lg<tm1Imx>",null,"Semi-dominant","CD40 ligand","Cd40lg","Nil","CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5","MGI:88337","targeted mutation 1, Immunex","Cd40lg<tm1Imx>","MGI:1857145","X",{"$nulls":15},"Yes",{"$nulls":13},"Immune system phenotype:* serum IgM and IgG3 levels are more or less normal at all ages.Abnormal immune system organ morphology.Absent spleen germinal center:* failure to form germinal centers.Abnormal lymph node morphology.Lymph node hypoplasia:* about 1/3 that of controls while overall T and B cell numbers are normal.Absent lymph node germinal center:* failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal.Abnormal immune system physiology.Abnormal class switch recombination.Decreased immunoglobulin level.Decreased IgA level.Decreased IgE level: undetectableDecreased IgG1 level.Decreased IgG2b level.Abnormal antigen presentation:* unable to mount a secondary response to TNP-KLH antigen (T cell dependent).* T cell independent responses are normal as is isotype switching for these antigens.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[1363,"IL2 KO","B6.129-IL2<tm1Hor>/Wehi",null,"Recessive","interleukin 2","Il2","Nil","IL-2","MGI:96548","targeted mutation 1, Ivan Horak","Il2<tm1Hor>","MGI:1857191","3",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible.  Impaired CD4 T cell function and reduced natural killer cell activity.Immune system phenotype:* bone marrow chimeras (mutant bone marrow in Rag2-deficient hosts) do not develop a wasting autoimmune disease compared to the lethal disease that develops with Il2ratm1Dw bone marrow chimeras.Increased T cell number.Increased CD4-positive T cell number:* activated T cell numbers fail to decrease to normal levels after immunization with staphylococcal enterotoxin, indicating a problem with peripheral deletion.* Increased CD8-positive T cell number:* activated T cell numbers decrease with slower kinetics than wild-type mice after after immunization with staphylococcal enterotoxin.Increased activated T cell number:* higher numbers due to less sensitivity to Fas-mediated cell death (apoptosis).Increased T cell proliferation:* T cells continue to respond to antigen instead of going into anergy during secondary stimulation with antigens.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22"]
[8777,null,"ASD937:Pomegranate:87",null,"Recessive","blicr ",{"$nulls":7},"Unknown",{"$nulls":28},"unknown","unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-08-12","Cryopreserved sperm"]
[1845,null,"B6.129P2(B6)-IL10<tm1Cgn>/Wehi",null,"Recessive","interleukin 10","Il10","Nil","cytokine synthesis inhibitory factor, IL-10","MGI:96537","interleukin 10; targeted mutation 1, University of Cologne","Il10<tm1Cgn>","MGI:1857199","1",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani. Intestinal problems are far less severe (local inflammation of the proximal colon) in a pathogen-free environment. Lymphoctye development and antibody responses are normal in homozygous mutant mice. For a more detailed description please refer to the JAX Notes Fall 1997 article.   Homozygotes may be small, possibly anemic and may develop inflammatory bowel disease. ",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10"]
[1928,"Kit-W<sh>","C57BL/6J-Kit<W-sh>/HNihrJaeBsmJAnuApb",null,"Recessive","kit oncogene","Kit","Nil","belly-spot, c-KIT, CD117, Dominant white spotting, Steel Factor Receptor, Tr-kit","MGI:96677","kit oncogene; sash","Kit<W-sh>","MGI:1856265","5",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal coat/hair pigmentation: the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail.Absent coat pigmentation: classic black eyes and white coat.Abnormal hematopoiesis.Abnormal erythrocyte cell number.Decreased erythrocyte cell number: on this background,lower than normal mean hematocrit values were found but did not manifest as an anemia.Decreased mast cell number: mice are described as being mast cell deficient.","Variable body spotting: appears as a distinctive broad white sash","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2007-08-23","Cryopreserved sperm"]
[1931,null,"B6.129S4-C3<tm1Crr>/JAnuApb","B6.129S4-C3<tm1Crr>/JAnuApb","Recessive","complement component 3","C3","Nil","acylation stimulating protein, complement factor 3, Plp","MGI:88227","complement component 3; targeted mutation 1, Michael C Carroll","C3<tm1Crr>","MGI:1861799","17",{"$nulls":15},"No",{"$nulls":12},"Immuno-compromised.  Mice homozygous for the C3 (complement component C3) targeted mutation are viable and fertile. Homozygous mutants exhibit an increased susceptibility to lethal infection by Group B streptococci. Reductions in peritoneal mast cell degranulation, production of tumor necrosis factor alpha, neutrophil infiltration and bacterial clearance have also been reported in these mice.   Homozygotes also demonstrate a profound defect in antibody response to T cell dependent antigens. They show a diminished level of peanut agglutin+ germinal centers and a failure in isotype switching despite normal B cell signalling in vitro. ",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-23","Cryopreserved sperm"]
[1966,"available from Animal Resources Centre - www.arc.wa.gov.au","FVB/NJ",null,"Dominant","Inbred albino. A, Tyr<c>, Pde6b<rd1>, H-2<q>",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No",{"$nulls":12},"Useful for production of transgenic mice as fertilised eggs contain large and prominent pronuclei which facilitates the microinjections of DNA. Large litters.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-09-04"]
[3404,"ACT-mOVA-II","C57BL/6-Tg(CAG-OVA)916Jen",null,"Dominant",{"$nulls":25},"transgene insertion 916, Marc K Jenkins","chicken β-actin",{"$nulls":10},"Ubiquitously express membrane bound chicken ovalbumin under the control of chicken β-actin promoter.  Breed less well than hets",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13"]
[3431,"Nodal<lacZ>","C57BL/6-Nodal<tm1Rob>/Wehi",null,"Recessive","nodal","Nodal","Nil","Tg.413d","MGI:97359","targeted mutation 1, Elizabeth J Robertson","Nodal<tm1Rob>","MGI:2180793","10",{"$nulls":15},"No","lacZ (Beta-galactosidase)","endogenous",{"$nulls":10},"Embryonic lethal at gastrulation","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15"]
[3520,"NOD.Idd11D","NOD.B6-Idd11<C57BL/6>/Wehi",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11; C57BL/6","Idd11<C57BL/6>","MGI:3036811","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes. It is best to best to begin monitoring development of glycosuria at weekly intervals starting at 10 wks of age.  Use of the strains generated defines the IDD region to between D4Mit72 ad D4Mit203",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2008-07-28"]
[3576,null,"BALB/c-Tg(CMV-cre)1Cgn/JWehi",null,"Dominant",{"$nulls":25},"transgene insertion 1, University of Cologne ","human cytomegalovirus minimal promoter",{"$nulls":10},"In this transgenic strain, deletion of loxP-flanked genes occurs in all tissues, including germ cells. The Cre gene in this strain is under the transcriptional control of a human cytomegalovirus minimal promoter and is likely to be expressed before implantation during early embryogenesis. It also appears to be X-linked since transgene transmission through males is restricted to female offspring.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04"]
[4945,"EIIa-cre","B6.FVB-Tg(EIIa-cre)C5379Lmgd/JApb",null,"Dominant",{"$nulls":25},"transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal","adenovirus EIIa promoter",{"$nulls":11},"Normal.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2009-12-04","Cryopreserved sperm"]
[5119,"Ednrb s/sl","B6.C3H-Ednrb<s-l>/J",null,"Recessive","endothelin receptor type B","Ednrb","Nil","ETb, ETR-b, Sox10m1","MGI:102720","endothelin receptor type B; piebald lethal","Ednrb<s-l>","MGI:1856149","14",{"$nulls":28},"Postnatal lethality: * most usually die by 15 days of age * some live to breed but die between 3 and 15 months of ageAbnormal coat/hair pigmentation.Absent coat pigmentation: mice are white-coated with small patches of pigmented hair about the eyes,ears and tail.Megacolon: * distal four sections of the colon are aganglionic * grossly evident via markedly distended colon in weaning age or older mice.Abnormal enteric ganglia morphology: deficiency of ganglion cells of the myenteric plexus of the lower colon.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-05-12"]
[5489,null,"CBACaJ;129S-Chrna9<tm1Jbdv>/J",null,"Recessive","cholinergic receptor, nicotinic, alpha polypeptide 9","Chrna9","Nil","Acra9, Gm8311","MGI:1202403","cholinergic receptor, nicotinic, alpha polypeptide 9; targeted mutation 1, Belen Elgoyhen and Douglas E Vetter","Chrna9<tm1Bedv>","MGI:2158742","5",{"$nulls":15},"Yes",{"$nulls":12},"Hearing/vestibular/ear phenotype: * homozygotes are viable with a normal Preyer's reflex and no gross deficits in balance or movement. * no structural abnormalities in cochlear hair cells, supporting cells or spiral ganglion neurons are observed. * in addition, development and position of the olivocochlear bundle remains unchanged. * in vitro, mutant apical OHCs exhibit normal electromotility in response to a 100-Hz sinusoidal voltage command relative to wild-type OHCs.Abnormal cochlear IHC efferent innervation pattern: * unlike wild-type mice, homozygotes appear to lack a sparse plexus of efferent terminals in close apposition to the IHC somata * however, a dense plexus of terminals is still present below the IHCs.Abnormal cochlear OHC efferent innervation pattern: * most efferent terminals under mutant OHCs occur as large singlets rather than as clusters of roughly equal-size terminals * most mutant OHCs are contacted by only one terminal (66.7%) and very few by >2 terminals, whereas 61.8% of wild-type OHCs are contacted by two terminals.Abnormal cochlear nerve compound action potential: * at 6-24 weeks, homozygotes fail to show suppression of compound action potential (CAP) amplitudes during efferent fiber activation by olivocochlear (OC) shocks * however, in the absence of crossing OC bundle electrical stimulation, homozygotes display normal CAP thresholds at 16 kHz relative to wild-type mice * also, at 4-9 weeks, homozygotes show normal mean CAP threshold curves over the entire range of mouse hearing (between 1.7 and 50 kHz) relative to 129S6/SvEvTac control mice.Abnormal distortion product otoacoustic emission: * homozygotes fail to show suppression of distortion product otoacoustic emissions (DPOAEs) during efferent fiber activation by olivocochlear (OC) shocks * however, in the absence of OC bundle electrical stimulation, homozygotes display normal DPOAEs relative to wild-type mice.",null,"129S1/Sv x CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-04-21"]
[6607,"BXD-73","BXD73/RwwJArc",null,"Recessive",{"$nulls":37},"Normal","Normal","C57BL/6J x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"brother x sister","No","2011-10-04","Embryo"]
[7185,"LRKK2","B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/JAusb","B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/JAusb","Dominant",null,"G2019S-LRRK2",null,null,"MGI:4950671",{"$nulls":3},"Unknown",{"$nulls":28},"These tg mice display progressive nigral dopaminergic degeneration, in addition to reduced complexity of cultured midbrain dopaminergic neurons.Also exhibit enhanced dopamine turnover in the olfatory bulb, as well as autophagic and mitochondrial abnormal.",null,"C57BL/6J x C3H/HeJ F1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02"]
[7775,"MyD88 knockout","B6.129P2(SJL)-Myd88<tm1.1Defr>/JMarpApb",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1.1, Anthony L DeFranco","Myd88<tm1.1Defr>","MGI:4421295","9",{"$nulls":28},"Homozygous mice are viable and fertile. The Myd88-deficient allele encodes a deletion of exon 3 of the myeloid differentiation primary response gene 88 gene. MYD88 is a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. MyD88 signaling is required to limit bacterial burden and prolong survival during infection. Myd88-deficiency is associated with a number of immune system abnormalities, as well as hematopoietic system, molecular signaling, and apoptotic abnormalities. These mice have increased susceptibility to bacterial and viral infection and should be maintained in a specific pathogen free environment.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"homo x homo","No","2014-10-24","Cryopreserved sperm"]
[7242,"DMP-1-Cre Recql4","C57BL/6-Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Tg(Dmp1-Cre)1Jqfe/Apb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":9},"Unknown to Unknown",{"$nulls":6},"transgene insertion 1, Jian Q Feng","Dmp1","odontoblast",{"$nulls":9},"Homozygous animals are normal, fertile and viable (floxed line with eYFP reporter of cre activity)","Normal, fertile and viable (floxed line with eYFP reporter of cre activity)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","generated on pure C57Bl/6 so not backcrossed. Only maintained on C57",null,"homozygous R26eYFP Recql4fl/fl in breeding","No","2012-12-06","Cryopreserved sperm"]
[7789,null,"C57BL/6JAnu-Elovl3<m1Anu>/AnuApb","C57BL/6JAnu-Elovl3<m1Anu>/AnuApb","Recessive","elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3","Elovl3","Unknown","Cig30, CIN-2","MGI:1195976",{"$nulls":3},"19","ENSMUSG00000038754","ENSMUST00000043739","Elovl3-001","545","718","T to A","ENSMUSE00000380471","4","182","Methionine to Lysine",{"$nulls":4},"GACCATGAACTTTGGCGTCCATTCTGTCATGTACACTTACTACACTATGAAGGCTGCCAAA",{"$nulls":13},"Hom mice have sparse fur and can been phenotyped at weaning",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-11-19","Cryopreserved sperm"]
[7787,"Dynll-SHH","C57BL/6-Dynll1<tm1.1Jhh> Shh<tm1(EGFP/Cre)Cjt>/StvApb",null,"Dominant","dynein light chain LC8-type 1","Dynll1","Normal","8kDa LC, DLC8, Dnclc1, Pin","MGI:1861457","dynein light chain LC8-type 1; targeted mutation 1.1, Jorg Heierhorst","Dynll1<tm1.1Jhh>",null,"5",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2014-11-17","Cryopreserved sperm"]
[7794,"MPEG1 targeted KO clone 7F","C57BL/6J-Mpeg1<tm1Pib>7F/PibMarpApb",null,"Dominant","macrophage expressed gene 1","Mpeg1",null,"Mpg-1, MPS1","MGI:1333743",{"$nulls":3},"19",{"$nulls":28},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2014-11-25","Cryopreserved sperm"]
[8780,"Tph2-GFP","CD1.FVB/N-Tg(Tph2-EGFP)LO210Gsat/Apb",null,"Dominant",{"$nulls":25},"transgene insertion LO210, GENSAT Project at Rockefeller University","Tph2",{"$nulls":10},"GFP expressed in Tph2-expressing cells. No other phenotype abnormalities. Breeding not great as Homs","GFP expressed in Tph2-expressing cells. No other phenotype abnormalities. prefer maintain line as hets for breeding.","Crl:CD1(ICR) ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-19","Cryopreserved sperm"]
[7797,"Favola ; Cx40T202STg ; DeltaF","B6.CBA-Tg(Tie2-Gja5*T202S/EGFP)1/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, ","endothelial-specific receptor tyrosine kinase; Tie2, Tek",{"$nulls":11},"Expression of mutant form of Cx40 (Gja5) (amino acid substitution T202S at endothelial gap junctions.Body weight, blood pressure and heart rate are normal.Expression of transgene results in significant decrease in Cx37 expression.Endothelial Cx40T202S expression enhances myogenic activation and impairs endothelium-derived hyperpolarization (EDH) in mesenteric resistance arteries.Endothelial Cx40T202S expression increases stiffness of mesenteric resistance arteries. ","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","8",null,null,"No","2014-11-25","Cryopreserved sperm"]
[8756,"R26-LSL-Adar1 p110","C57BL/6-Gt(ROSA)26Sor<tm2(Adar1p1100)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",null,"Gt(ROSA)26Sor<tm2(Adar1p110)Cwa>",null,"6",{"$nulls":28},"Normal (requires Cre to induce expression of Adar1 p110 isoform ectopically)","Normal (requires Cre to induce expression of Adar1 p110 isoform ectopically)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-31","Cryopreserved sperm"]
[7810,"R26CreER RARaRARg R26eYFP","B6.Cg-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> RARa<tm1Ipc> RARg<tm1Ipc> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive","retinoic acid receptor, alpha","Rara","Nil","RARalpha1, RAR alpha 1","MGI:97856","retinoic acid receptor, alpha; targeted mutation 1, Pierre Chambon","Rara<tm1Ipc>","MGI:1857622","11",{"$nulls":16},"transgene insertion 1, Douglas T Fearon","granzyme B",{"$nulls":10},"In absence of tamoxifen cells are wildtype, when treated with tamoxifen loss of the vitamin A receptors, RARa and RARg occur, causing different phenotypes in distinct cell types.","Unknown","C57BL/6","Yes","Unknown","Unknown","Yes","Unknown","Unknown","No","Excellent","At least 10",null,null,"No","2014-12-10"]
[7810,"R26CreER RARaRARg R26eYFP","B6.Cg-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> RARa<tm1Ipc> RARg<tm1Ipc> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Nil","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6"]
[7808,"ENU28:011:Etaa1","C57BL/6NCrlAnu-Etaa1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Etaa1<m1Anu>/AnuApb","Recessive","Ewing tumor-associated antigen 1","Etaa1","Unknown","5730466H23Rik","MGI:1915395",{"$nulls":3},"11","ENSMUSG00000016984","ENSMUST00000076661","Etaa1-001",{"$nulls":7},"17952576","2",null,null,"TCAAAATTCTCCAATGACAAAGCAGTTAGGTAATCTGTTGTTATTTTTATGTGGGTAGGT",{"$nulls":13},"Poor response to immunisation.Partial embryonic lethality",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-12-08","Cryopreserved sperm"]
[7256,"APN275","C57BL/6N(Ag)-Katnb1<tm1a(EUCOMM)Hmgu>MarpApb",null,"Recessive","katanin p80 (WD40-containing) subunit B 1","Katnb1 ",null,"2410003J24Rik, KAT ","MGI:1921437 ","katanin p80 (WD40-containing) subunit B 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH ","Katnb1tm1a(EUCOMM)Hmgu","MGI:4436305","8",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm"]
[8317,"CIB1 Transgenic ","C57BL/6-Tg(CAG-CIB1)/CcbApb",null,"Dominant",{"$nulls":25},"human Calcium and Integrin Binding Protein 1","Chicken Beta actin",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm"]
[7801,"Krt76 tm1c x K14CreER","B6(Cg)-Krt76<tm1c(KOMP)Wtsi> Tg(KRT14-Cre/ER)20Efu/MarpApb",null,"Recessive","keratin 76","Krt76","Nil","2310001L23Rik","MGI:1924305",{"$nulls":3},"15",{"$nulls":16},"transgene insertion 20, Elaine Fuchs","human keratin 14 (KRT14) promoter",{"$nulls":10},"Unkempt, dull coats and smaller body size,  scaling of skin of the tail, abnormal paw pad hyperpigmentation ","Abnormal sebaceous gland morphology, abnormal hair cycle, abnormal epidermis stratum basale morphology, hyperkerotosis, parakerotosis","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","0","6",null,"No","2014-11-26","Cryopreserved sperm"]
[8782,"R26-Adar1","C57BL/6-Gt(ROSA)26Sor<tm1(Adar1)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,null,"MGI:104735","Gt(ROSA)26Sor<tm1(Adar1)Cwa>",null,null,"6",{"$nulls":28},"Normal (Rosa26 Lox-Stop-Lox Adar1 cDNA); needs Cre exposure to activate Adar1 expression","Normal (Rosa26 Lox-Stop-Lox Adar1 cDNA); needs Cre exposure to activate Adar1 expression","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-04","Cryopreserved sperm"]
[7811,"MIP 1alpha","B6.129P2-Ccl3<tm1Unc>/J",null,"Recessive","chemokine (C-C motif) ligand 3","Ccl3","Nil","CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, Mip1a, MIP1-(a), MIP-1alpha, MIP-1 alpha, MIP1-alpha, Scya3","MGI:98260","chemokine (C-C motif) ligand 3; targeted mutation 1, University of North Carolina","Ccl3<tm1Unc>","MGI:1857243","11",{"$nulls":28},"Mice homozygous for the Ccl3 (chemokine [C-C motif] ligand 3) (also known as macrophage inflammatory protein 1a, Mip1a or Scya3) knock-out mutation are viable and fertile. Homozygous mutant mice are resistant to Coxsakievirus-induced myocarditis. Mutant mice infected with influenza virus show reduced pneumonitis and delayed clearance of virus. There are no overt hematopoietic abnormalities. Bone remodeling induced by mechanical loading during orthodontic tooth movement was significantly decreased in Ccl3tm1Unc mice. Compared to wild-type mice liver fibrosis was reduced upon treatment with either carbon tetrachloride or methionine- and choline-deficient diets to induce fibrosis. Melanoma growth is augmented and lung metastasis is enhanced in these knock-out mice. With renal cell carcinoma, however, the number of metastasis foci in the lung is reduced, and intra-tumoral neovascularization, an indispensable process for metastasis, is attenuated in these gene-deficient mice. These mice can be useful in studies of chemokine receptors in inflammatory diseases.","Unknown","C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",null,"13","Brother x sister","No","2014-12-10","Cryopreserved sperm"]
[7819,"Ctss KO:MHC II KO","B6NCrl;129-Ctss<tm1Hap> H2<dlAb1-Ea>/AnuApb",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17"]
[8784,"R26-LSL-Adar1 Za","C57BL/6-Gt(ROSA)26Sor<tm5(Adar1Za)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",null,"Gt(ROSA)26Sor<tm5(Adar1Za)Cwa>",null,"6",{"$nulls":28},"normal (requires Cre to express Adar1 cDNA)","Normal (requires Cre to express Adar1 cDNA)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-04"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow"]
[7831,"tTA","FVB.Cg-Tg(Myh6-tTA)6Smbf/VccriApb",null,"Dominant",{"$nulls":25},"transgene insertion 6, Section of Myocardial Biology - Fishman Lab","rat Myh6 promoter",{"$nulls":10},"Unknown","Normal","FVB/n","Unknown","Unknown","Yes","Unknown","Unknown","Unknown","No","Excellent","more than 10","N/A","FVB/n male x hemizygous tTA female","No","2015-01-13","Cryopreserved sperm"]
[7836,"Louise:TCR:Ly5a::N12","C57BL/6JSfdAnu-Tg(TLK2mHEL)2Ccg TCR:Ly5a::N12 /AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid","Ly5a",{"$nulls":7},"Unknown","Express low levels of membrane bound HEL in thyroid. Low serum levels of HEL detected.",null,"C57BL/6JStdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5","sib x sib","No","2015-01-25","Cryopreserved sperm"]
[{"$nulls":30},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid"]
[7835,"Foxp3-gfp:kk:TCR:N12","B6.B10.BR-H2<k2> Foxp3<tm2Ayr> Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X",{"$nulls":15},"No","transgene insertion 1, Mark M Davis",null,null,"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","Histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Normal. Cells expressing FoxP3 fluoresce green, predominantly T cells.T cell express T cell receptor alpha and beta (Tcra and Tcrb, respectively) chains from the hen egg lysozyme (HEL)-specific T cell hybridoma 3A9",null,"129 x C57BL/6 x C57BL10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-01-25","Cryopreserved sperm"]
[8787,"hScl-CreER R26eYFP Srsf2P95H/+","B6-Srsf2<tm2874(P95H)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Tg(Tal1-cre/ERT)42-056Jrg/Apb",null,"Recessive","serine/arginine-rich splicing factor 2","Srsf2",null,"D11Wsu175e, MRF-1, SC35, Sfrs10, Sfrs2","MGI:98284",{"$nulls":3},"11",{"$nulls":16},"transgene insertion 42-056, Joachim R Gothert",{"$nulls":11},"\"normal\" - requires tamoxifen treatment to induce Srsf2 mutation to heterozygosity","\"normal\" - requires tamoxifen treatment to induce Srsf2 mutation to heterozygosity","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-06","Cryopreserved sperm"]
[7843,"CD11c-DTR","B6.Cg-Tg(Itgax-DTR/EGFP)57Lan/AnuApb",null,"Semi-dominant",{"$nulls":25},"transgene insertion 57, Richard A Lang","mouse Itgax promoter (CD11c)",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-02-16","Cryopreserved sperm"]
[7846,"Foxp3-gfp:kk:TCR:Arjuna:N12","B6.B10.BR-H2<k2> Foxp3<tm2Ayr> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X",{"$nulls":15},"No","transgene insertion 1, Mark M Davis",{"$nulls":11},"Normal. Cells expressing FoxP3 fluoresce green, predominantly T cells.T cell express T cell receptor alpha and beta (Tcra and Tcrb, respectively) chains from the hen egg lysozyme (HEL)-specific T cell hybridoma 3A9.Islet cells express HEL on cell surface.",null,"129 x C57BL/6 x C57BL10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-02-19"]
[7849,"Spi6-/-ROSA26eYFP+/+CreERT2+","B6(Cg)-SerpinB9a<tm2Pib> Gt(ROSA)26Sor<tm1(EYFP)Cos> Tg(Gzmb-Cre/ERT2)1Dtf/MarpApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor ",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6"]
[7852,"ENU34:G2","ANU:ENU34:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-03-04","Cryopreserved sperm"]
[7854,null,"ENU27:041:Card11",null,"Recessive","caspase recruitment domain family, member 1","Card11","Unknown","0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1","MGI:1916978",{"$nulls":3},"5","ENSMUSG00000036526","ENSMUST00000085786","Card11-201","1093","1414","A to T","ENSMUSE00000431469","8","365","Methionine to Lysine",{"$nulls":4},"GGAAGGACTGTGAAATGTACAAGCACCGCATGAACACAGTTATGCTGCAGCTGGAGGAGGT",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-03-05","Cryopreserved sperm"]
[7857,"Sppl2a:Ctss KO","C57BL/6JAnu-Sppl2a<m1Anu> Ctss<tm1Hap>/AnuApb","C57BL/6JAnu-Sppl2a<m1Anu> Ctss<tm1Hap>/AnuApb","Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802 ","signal peptide peptidase like 2A; mutation 1, The Australian National University","Sppl2a<m1Anu>","MGI:5432126","2","ENSMUSG00000027366","ENSMUST00000028844","2010106G01Rik-001",{"$nulls":7},"126746052","7",null,null,"ATTCATAGGATGCCATGTGGACAGTGCACGTACGTATCTGTTAGCCTATGATGCAATTAG",{"$nulls":13},"Unknown","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-03-10","Cryopreserved sperm"]
[7858,"ENU15NIH:085:CD74KO","C57BL/6JAnu-Cd74<tm1Liz> Sppl2a<m1Anu>/AnuApb",null,"Recessive","CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)","Cd74","Nil","CLIP, Ii","MGI:96534","CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Elizabeth Bikoff","Cd74<tm1Liz>","MGI:1927530","18"]
[7860,"Rosa26-Cryab floxed knockin","B6;C-Gt(ROSA)26Sor<tm1(Cryab-FLAG)Kkha>/KkhaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Increased","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","Rosa26-Cryab-KI","Cryab-FLAG",null,"6",{"$nulls":28},"Floxed mice are viable and fertile","floxed mice are viable and fertile","C57BL/6 and Balb/C mixed background","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-03-18","Cryopreserved sperm"]
[7865,"TRAMP","C57BL/6-Tg(TRAMP)8247NgApb",null,"Recessive",{"$nulls":25},"transgene insertion 8247, Norman M Greenberg","rat Probasin promoter",{"$nulls":10},"Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.","Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"Yes","2015-04-08","Cryopreserved sperm"]
[1236,"Pinky ; ENU8C:027","B6JSfdAnu;CBA(Cg)-Zbtb16<pnky>/AnuApb","B6JSfdAnu;CBA(Cg)-Zbtb16<pnky>/AnuApb","Recessive","zinc finger and BTB domain containing 16","Zbtb16","Unknown","Green's luxoid, PLZF, Zfp145","MGI:103222","pinky","Zbtb16<pnky>","MGI:4462277","9","ENSMUSG00000066687","ENSMUST00000093852","Zbtb16-201","210","457","T to A","ENSMUSE00000584531","2","70","Tyrosine to STOP",{"$nulls":4},"ATCCTCTTCCACCGAAACAGCCAGCACTATACTCTAGACTTCCTCTCGCCAAAAACCTTCC","Yes",{"$nulls":12},"Limb deformity. Shortening and angular deformity of hindlimbs with extra digits present in some cases. Deformity affects mouse mobility.   Previously described homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.",null,"C57Bl6JSfdAnu x CBA/HAnu","Yes","No","Yes","Yes","No","Yes","Yes","Good","1 to B6JSfdAnu, 1x CBH/CaJ",null,null,"No","2007-06-15","Cryopreserved sperm"]
[7870,"MHC II KO","B6NCrl;129-H2<dlAb1-Ea>/AnuApb",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":28},"Increased susceptibility to bacterial infection:• mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively• mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice.Decreased CD4-positive, alpha beta T cell number:• significantly decreased number of CD4+ thymocytes• almost completely absent in spleen and lymph nodesIncreased CD8-positive, alpha-beta T cell number.Abnormal immunoglobulin level:* decreased IgG1 level* decreased IgG2a level* increased IgM level",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16","Cryopreserved sperm"]
[7869,null,"ENU18Flt3-ITD:G1(24)",null,"Recessive","Unknown",{"$nulls":7},"Unknown"]
[7871,"Sppl2a KO1 conditional","B6.Cg-Sppl2a<tm1c(EUCOMM)Hmgu> Tg(ACTFLPe)9205Dym/1MarpAnuApb",null,"Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802","signal peptide peptidase like 2A; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Sppl2a<tm1c(EUCOMM)Hmgu>","MGI:4887673","2",{"$nulls":16},"transgene insertion 9205, Susan Dymecki","ACTB, actin, beta, human","The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively",{"$nulls":9},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16","Cryopreserved sperm"]
[7872,"Sppl2a KO2 conditional","B6.Cg-Sppl2a<tm1c(EUCOMM)Hmgu> Tg(ACTFLPe)9205Dym/2MarpAnuApb",null,"Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802","signal peptide peptidase like 2A; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Sppl2a<tm1c(EUCOMM)Hmgu>","MGI:4887673","2",{"$nulls":16},"transgene insertion 9205, Susan Dymecki","ACTB, actin, beta, human","The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively",{"$nulls":9},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16","Cryopreserved sperm"]
[7879,"Spotty","STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 47, Elaine Fuchs","tetracycline-responsive promoter element (TRE) and cytomegalovirus regulatory elements (mCMV)",{"$nulls":10},"Normal","Normal","Mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16"]
[7885,"C57BL/6-Nabp1-KO strain 2","STOCK Nabp1<tm1.1Kkha>/2KkhaApb",null,"Recessive","nucleic acid binding protein 1","Nabp1","Normal","Nbp1, Obfc2a, Ssb2","MGI:1923258","targeted mutation 1.1, Kum Kum Khanna","Nabp<tm1.1Kkha>",null,"1",{"$nulls":28},"Viable and Fertile","Viable and Fertile","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"homozygous x homozygous","No","2015-04-21"]
[7684,"Thunder","B6(Cg)-Hnrnpll<thdr>/AnuApb","B6(Cg)-Hnrnpll<thdr>/AnuApb","Recessive","heterogeneous nuclear ribonucleoprotein L-like","Hnrpll","Nil",null,"MGI:1919942","heterogeneous nuclear ribonucleoprotein L-like; thunder","Hnrpll<thdr>","MGI:3707008","17","ENSMUSG00000024095","ENSMUST00000061331","Hnrpll-201","407","683","T to A","ENSMUSE00000138333","2","136","Valine to Aspartic acid",{"$nulls":4},"TGTCCATGTTCGAGGGCTCTGTGAATCTGTTGTGGAAGCTGACCTTGTGGAGGCACTGGAG","Yes",{"$nulls":12},"Low T cell numbers which are hyperactivated. By flow cytometric staining of blood, initially detected a strain with CD4 T cells decreased to 25% of wild-type. Further analysis revealed entirely normal thymic development and single positive cells, but a marked reduction in the number of peripheral T cells especially naïve CD4 and CD8 cells, and poor survival of thunder T cells upon adoptive transfer. During this analysis, it was found that thunder thymocytes stain with the RA3-6B2 antibody that selectively recognizes the CD45RABC B220 isoform normally restricted to B cells. Staining with antibodies to CD45RA, B or C showed a 50-fold increase in staining on all thymocytes and peripheral T cells, as well as macrophages and dendritic cells, so that the staining intensity matched that on B cells. Amplification of cDNA with primers spanning CD45 exons 4-6 showed a dramatic increase in the inclusion of these exons in thymocyte CD45 mRNA, establishing that the thunder mutation interferes with the normal CD45 exon 4-6 silencing process.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10","7",null,"No","2014-05-16","Cryopreserved sperm"]
[7545,"Jnk2 KO","B6.129-Mapk9<tm1Flv>/JAnuApb","B6.129-Mapk9<tm1Flv>/JAnuApb","Recessive","mitogen-activated protein kinase 9","Mapk9","Nil","JNK2, JNK/SAPK alpha, Prkm9","MGI:1346862","mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell","Mapk9<tm1Flv>","MGI:2176243","11",{"$nulls":28},"Abnormal keratinocyte morphology:• exhibit greater number of keratinocyte stem cells in skinAbnormal keratinocyte differentiation:• keratohyalin granules, markers of epidermal differentiation, are increased in the stratum granulosumEpidermal hyperplasia:• keratinocyte hyperplasia, resulting in an increased number of epithelial cell layersThick epidermis.Abnormal liver physiology:• exhibit protection from galactosamine/lipopolysaccharide (GalN/LPS)-induced liver injury, showing decreased injury, mortality, and blockage of the TNF death pathway and mitochondrial death pathway (decrease in Bid cleavage, mitochondrial translocation, and cytochrome c release)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-12-13","Cryopreserved sperm"]
[8748,"S1ECN*Smad1-ERT-cre-neu","STOCK Smad1<tm2Rob> Tg(Elf5-rtTa-TetO) Tg(MMTVneu)202Mul/Apb",null,"Recessive","SMAD family member 1","Smad1",null,"Madh1, Madr1, Smad 1","MGI:109452","SMAD family member 1; targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":16},"Elf5-rtTa-TetO",{"$nulls":11},"These mice are normal and breed well, and develop normally. Adult mice older than 6 month may develop multiple tumours in mammary glands.Younger mice seem to be more active than wild type mice. At the moment the phenotype of smad1 CRE/ERT mediated deletion is unknown.Doxycycline is required from a young age for effective knockout of Smad1.","ERT/CRE  and NEU modifications are active in heterozygous setting, so the above phenotype is the same. Smad1 flox is required in the homozygous state for effective knockout.","mixed-mainly BALBc and FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-04","Cryopreserved sperm"]
[7813,"FLPe","B6.Cg-Tg(ACTFLPe)9205Dym/J",null,"Recessive",{"$nulls":25},"FLP1, FLP1 recombinase, Saccharomyces cerevisiae","ACTB, actin, beta, human","expression of the enhanced FLP1 recombinase variant (FLPe) is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5",{"$nulls":9},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"6","brother X sister","No","2014-12-11","Cryopreserved sperm"]
[7623,"RQ/B6 ; GABRG2 R43Q","B6.129-Gabrg2<tm1Spet>/Apb",null,"Dominant","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2","Gabrg2","Reduced",null,"MGI:95623","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; targeted mutation 1, Steven Petrou","Gabrg2<tm1Spet>","MGI:3764923","11",{"$nulls":28},"Partial perinatal lethality:• mice are rarely bornComplete postnatal lethality:• mice that are born die before P19Tremors:• mice that are born exhibit a severe tremorAbnormal gait:• mice that are born have altered gaitsAbnormal brain wave pattern:• mice lack normal brain rhythms","Mice heterozygous for the mutation demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man. Seizures in the mouse showed an abrupt onset at around age 20 days corresponding to the childhood nature of this disease. Reduced cell surface expression of gamma2(R43Q) was seen in heterozygous mice in the absence of any change in alpha1 subunit surface expression","C57BL/6J","No","No","Yes","No","No","Yes","No","Unknown","8",null,null,"No","2014-03-24","Cryopreserved sperm"]
[7518,"HA-TetO (4)","C57BL/6-Tg(tetO-CYP19A1)4/MarpApb",null,"Dominant",{"$nulls":25},"Human Aromatase ; human cytochrome P450, family 19, subfamily a, polypeptide 1","TetO",{"$nulls":10},"None; no phenotype","None; no phenotype","C57BL/6J","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-11-29","Cryopreserved sperm"]
[3938,"HtrA3-KO (MP10 Cre55)","C57BL/6-Htra3<tm1>55",null,"Recessive","HtrA serine peptidase 3","Htra3","Nil",null,"MGI:1925808",{"$nulls":3},"5",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-10-16","Cryopreserved sperm"]
[7886,"Osx-Cre R26eYFP Recql4fl/fl","C57BL/6-Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb Tg(Sp7-tTA,tetO-EGFP/cre)1Amc ",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6"]
[7890,"Ets1f/fxLysMCre","B6.Cg-Ets1<fl> Lyz2<tm1(cre)Ifo>/Marp",null,"Dominant","lysozyme 2","Lyz2 ",null,"Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp","MGI:96897","ysozyme 2; targeted mutation 1, Irmgard Forster","Lyz2<tm1(cre)Ifo>","MGI:1934631","10"]
[7502,"KI-Rag2/EGFP","129S6/SvEVTac-Rag2<tm2Fwa>/FwaAusb",null,"Dominant","recombination activating gene 2","Rag2","Normal","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 2, Frederick W Alt","Rag2<tm2Fwa>","MGI:3623131","2",{"$nulls":28},"No abnormal phenotype detected:• homozygotes produce Rag2 protein capable of V(D)J recombination and exhibit normal lymphocyte development; mice are used to analyze Rag2 expression in primary and peripheral lymphoid tissues",null,"129S6/SvEvTac","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-19"]
[7504,"Lig4-Y288C","B6(Cg)-Lig4<tiny>/ApbAusb","B6(Cg)-Lig4<tiny>/ApbAusb","Recessive","ligase IV, DNA, ATP-dependent","Lig4","Reduced","DNA ligase IV, ligase IV","MGI:1335098","tiny","Lig4<tiny>","MGI:3584400","8","ENSMUSG00000049717","ENSMUST00000095476","Lig4-201","863","1161","A to G","ENSMUSE00000610685","2","288","Tyrosine to Cysteine",{"$nulls":4},"CATGCAGATGCACAAAGATGGCGCGCTGTACCGGTACTTCTCCAGAAACGGTTACAACTAT","No",{"$nulls":12},"Animal model for human LIGIV Syndrome.  Small stature.  Severe combined immune deficiency. Hypogammaglobulinemia, no antibody response to immunization, very few circulating B or T cells. Hemopoiesis defect.  Hypoplastic anemia, hemopoietic stem cells unable to transplant, poorly proliferative in tissue culture, unable to compete with transplanted wild-type hemopoietic stem cells even in the absence of any conditioning regime.  Non-homologous end-joining DNA repair defect. Reduced DNA ligase IV protein levels and enzymatic activity. Western blot and immunofluorescent analysis of extracts from homozygous mutant mouse embryonic fibroblasts (MEFs) reveal 5-fold reduction in the protein level. Although the mutant protein complexes stably with XRCC4, in vivo adenylation activity is reduced 10-fold in mutant versus wild type MEFs.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-11-19"]
[7892,null,"ENU24:045:unknown",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Incidental phenotype of lower CD44 MFI on CD4 T cells (inheritence unclear)",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-05-15","Cryopreserved sperm"]
[7901,"Cd19-cre","C57BL/6JAnu-Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","CD19 antigen","Cd19",null,null,"MGI:88319","targeted mutation 1, University of Cologne","Cd19<tm1(Cre)Cgn>","MGI:1931143","7",{"$nulls":29},"Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-06-01","Cryopreserved sperm"]
[7897,"\"p75-AD\" mouse","129(Cg)-Ngfr<tm1Jae> Tg(APPSWE)2576Kha/Apb",null,"Dominant","nerve growth factor receptor (TNFR superfamily, member 16)","Ngfr","Reduced","LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16","MGI:97323","nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Rudolf Jaenisch","Ngfr<tm1Jae>","MGI:1857226","11",{"$nulls":16},"transgene insertion 2576, Karen Hsiao Ashe","Hamster Prion protein promoter","medium to high",{"$nulls":9},"Develop plaque in brain from 6-8 months of age. Cognitive performance is normal due to reduced p75 expression","Normal","129Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","20 or more","20","p75 null homozygotes mated to APP transgenic heterozygotes","No","2015-05-26","Cryopreserved sperm"]
[7906,"ENUProx1-GFP","ENUProx1-GFP",null,"Recessive",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-06-12","Cryopreserved sperm"]
[7904,"Astn2 KO","C57BL/6-Astn2<em1Pib>/Marp","MGI:5636645","Recessive","Astrotactin 2","Astn2","Nil","1d8, Astnl","MGI:1889277",null,"Astn2<em1Pib>","MGI:5636645","4",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",{"$nulls":3},"No","2015-06-12","Cryopreserved sperm"]
[7917,"Vav-cre","C57BL/6-Tg(Vav1-Cre)1Awr/WehiAnu",null,"Dominant",{"$nulls":25},"transgene insertion 1, Andrew W Roberts","Vav1","Haemopoietic",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-18","Cryopreserved sperm"]
[7921,"Pad4 KO","B6.Cg-Padi4<tm1.1Kmow>/KmowAnu",null,"Recessive","peptidyl arginine deiminase, type IV","Padi4","Nil","Pad4, PAD type IV, Pdi4","MGI:1338898","peptidyl arginine deiminase, type IV; targeted mutation 1.1, Kerri A Mowen","Padi4<tm1.1Kmow>","MGI:5285854","4",{"$nulls":28},"Abnormal neutrophil physiology:• neutrophils lack histone deimination unlike wild-type cellsdecreased susceptibility to viral infection• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice• however, influenza-infected mice exhibit normal survival, neutrophil recruitment into the lung, lung viral titers, and pro-inflammatory cytokine levelsDecreased susceptibility to weight loss:• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm"]
[7920,"VCE ER/Stop YFP:VAV-CreER","C57BL/-Tg(Vav1-cre/ERT)1Wehi/WehiAnu",null,"Dominant",{"$nulls":25},"Vav1-cre/ERT",{"$nulls":12},"Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm"]
[7927,"Mdm2<C305F>  S6<fl> Mx1-Cre","B6(Cg).129(Cg)-Mdm2<tm1.1Ypz> Rps6<tm1Gtho> Tg(Mx1-Cre)1Cgn/JAnu",null,"Recessive","ribosomal protein S6","Rps6","Normal","S6R","MGI:98159","ribosomal protein S6; targeted mutation 1, George Thomas","Rps6<tm1Gtho>","MGI:2387471","4"]
[7930,"A23.Foxp3-DTR","BALB/c(Cg)-Foxp3<tm3(DTR/GFP)Ayr> Tg(TcraA23,TcrbA23)#Ird/IrdApb",null,"Dominant","forkhead box P3","Foxp3",null,"JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 3, Alexander Y Rudensky","Foxp3<tm3(DTR/GFP)Ayr>","MGI:3698131","X",{"$nulls":16},"A23 T cell reeptor","T cell receptor",{"$nulls":10},"Restricted T cell receptor usage due to TCR transgene. ","As above","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-22","Cryopreserved sperm"]
[{"$nulls":30},"H⁺/K⁺ ATPase β subunit ; ATPase, H+/K+ exchanging, beta polypeptide","MHC I-E"]
[7938,"ENU31:016 B6","C57BL/6NCrlAnu-Gfi1<m1Anu>/AnuApb",null,"Recessive","growth factor independent 1","Gfi1","Unknown","Gfi-1, Pal1, Pal-1","MGI:103170",{"$nulls":3},"5","ENSMUSG00000029275","ENSMUST00000065478","Gfi1-201",{"$nulls":7},"107723722","2",null,null,"GGAGACCGTGCCTGCGCCGGGCAGAGCAGGTGCGAAGCGCGCAGAGGCCGGGTAGGGCAG",{"$nulls":13},"Activated CD8 T cells in blood.","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-26","Cryopreserved sperm"]
[8788,"R26-CreER Srsf2 P95H/+ Tet2fl/fl","B6-Srsf2<tm2874(P95H)Arte>  Tet2<tm1.1Iaai> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6"]
[7942,"ENU33:G3","ANU:ENU33:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-07-02","Cryopreserved sperm"]
[4768,"C57BL/6J.i-D<btm1>","C57BL/6;129P2-H2-D1<tm1Bpe>/AnuApb",null,"Recessive","histocompatibility 2, D region locus 1","H2-D1","Nil","H2-D1","MGI:95896","targeted mutation 1, Beatrice Perarnau","H2-D1<tm1Bpe>","MGI:1931445","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice lack H-2D<b> molecule and are deficient in  antigen presentation to CD8<+> T cells",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","2","sib x sib","No","2009-05-06","Cryopreserved sperm"]
[7949,"ENU36:G1","ANU:ENU36:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-07-23","Cryopreserved sperm"]
[7895,"HOM.bm1.407","B6-H2-K<bm1> Tg(RIP1-Bcl2)407Wehi/J","WEHI","Dominant","histocompatibility 2, K region","H2-K","Unknown",null,"MGI:3040519","histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17",{"$nulls":16},"human BCL2","rat insulin promoter","islet b cells",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Brother x sister and C57BL/6 x Positive","No","2015-05-18","Cryopreserved sperm"]
[7782,"203.4sv ; cTnI-G203S.4sv","129SvEv.B6-Tg(Myh6-TNNI3*G203S)4Chs/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher Semsarian","cardiac specific mouse αMHC promoter (alpha myosin heavy chain)","83% of endogenous",{"$nulls":9},"Unknown","Mice develop cardiac phenotype - hypertrophic cardiomyopathy by 21 weeks of age. Left ventricular hypertrophy was observed on echocardiography, it was associated with a significant 4-fold increase in RNA markers of hypertrophy, ANF and BNP. Myocyte hypertrophy, myofiber disarray and interstitial fibrosis were observed. ","129SvEv","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","10","4","Transgenic x non-transgenic sibs","No","2014-11-11","Cryopreserved sperm"]
[7953,"ENU29:030:Polr3b:B6","C57BL/6NCrlAnu-Polr3b<m1Anu>/AnuApb",null,"Recessive","polymerase (RNA) III (DNA directed) polypeptide B","Polr3b",null,"2700078H01Rik, A330032P03Rik, RPC2","MGI:1917678",{"$nulls":3},"10","ENSMUSG00000034453","ENSMUST00000077175","Polr3b-201","3365","3395","T to A","ENSMUSE00000514755","28","1122","Isoleucine to Asparagine",{"$nulls":4},"GCTCTTCCAGGAGTTACAGTCCATGAACATCATCCCCAGGCTGAAACTGGCCAAGTACAAC",{"$nulls":15},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-07-27","Cryopreserved sperm"]
[8767,"F8 KO (80B)","C57BL/6-F8<tm1Csl>/80BCslApb",null,"Recessive","coagulation factor VIII","F8",null,"Cf8, Cf-8, Factor VIII, FVIII","MGI:88383",{"$nulls":3},"X",{"$nulls":28},"Mice are haemophilic as they are deficient in the clotting factor, FVIII.","Mice may be haemophilic.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm"]
[7959,"Ghrelin","B6.129-Ghrl<tm1> Mboat4<tm1>/Marp",null,"Dominant","ghrelin","Ghrl","Nil","2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP","MGI:1930008",{"$nulls":3},"6",{"$nulls":28},"Body weight, neuroprotection, blood glucose","unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"het x het","No","2015-08-05"]
[7962,null,"ENU32:085:B6",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Poor",{"$nulls":3},"No","2015-08-12","Cryopreserved sperm"]
[7624,"Gabrg2KO","STOCK Gabrg2<tm1Lusc>/Apb",null,"Recessive","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2","Gabrg2","Nil","GABAA-R, Gabrg-2, gamma2","MGI:95623","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; targeted mutation 1, Bernhard Luscher","Gabrg2<tm1Lusc>","MGI:2177608","11",{"$nulls":28},"Complete postnatal lethality:• most mice died within a few days of birth, although the animals had normal birth weight and peripheral organ structure• remainder of surviving mice failed to thrive and none survived beyond P18Impaired righting response.Limb grasping.Hyperactivity:• exceessive hyperactivity in body and limb movement following birth.Abnormal gait:• described as duck walkNervous system phenotype: no obvious alterations in brain cytoarchitecture in newborn mutant mice (J:28662)",null,"DBA","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2014-03-24","Cryopreserved sperm"]
[7907,"STAT6DN","B6.129S2(C)-Stat6<tm1Gru>/J",null,"Dominant","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Michael J Grusby","Stat6<tm1Gru>","MGI:1888385","10",{"$nulls":28},"Mice homozygous for the Stat6<tm1Gru> mutation show a striking defect in the generation of Th2 cells. Lymphocytes are unable to respond to IL4 as measured in a variety of in vitro and in vivo assays. Stat6-deficient B cells do not produce IgE following in vivo immunization with anti-IgD. Mesenteric lymph node cells from STAT6-/- mice with colitis exhibited reduced secretion of IL-4, IL-5, IL-13, and IFN-gamma. They also show impaired Th2 differentiation and reduced airway response to allergen. With enhanced renal injury, Th1 and Th17 nephritogenic immune responses were increased in STAT6-/- mice while production of IL-5, a key Th2-associated cytokine, was decreased significantly.","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-16"]
[7850,"MPS IIIB KO","B6.129S6-Naglu<tm1Efn>/J",null,"Recessive","alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)","Naglu","Nil","MPS-IIIB; MPS3B; NAG; RGD1564228; UFHSD;","MGI Ref ID J:58950","Targeted mutation 1, Elizabeth F Neufeld","Naglu<tm1Efn>","MGI:1934018","11",{"$nulls":28},"At birth, homozygous null mice are viable, normal in size, and do not display any gross physical or behavioral abnormalities. The lysosomal enzyme alpha-N-acetylglucosaminidase (Naglu) is absent in all tissues. Large amounts of heparan sulfate accumulate in liver and kidney, and lesser amounts in other organs. At one month of age, vacuolated macrophages can be found in most tissues. Epithelial cells in kidney and neurons in some parts of the brain are also affected. The vacuolation becomes more prominent with age. At 4-5 months, the mice show abnormal behavior in an open field test. The life span is 8-12 months. Older animals may have urinary retention and difficulty walking and must be euthanized. The null mice were originally described as fertile, but their fertility has decreasd markedly with repeated back-crossing to an inbred strain. These mice are suitable for examining the pathophysiology of the Sanfilippo syndrome type B and for developing therapies for this lysosomal storage disorder.","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8","Brother x sister","No","2015-02-27","Cryopreserved sperm"]
[7083,"Pinky ; ENU8C:027","B6(Cg).CBA-Zbtb16<pnky>/AnuApb","B6.CBA-Zbtb16<pnky>/AnuApb","Recessive","zinc finger and BTB domain containing 16","Zbtb16","Unknown","Green's luxoid, PLZF, Zfp145","MGI:103222","zinc finger and BTB domain containing 16; pinky","Zbtb16<pnky>","MGI:4462277","9","ENSMUSG00000066687","ENSMUST00000093852","Zbtb16-201","210","457","T to A","ENSMUSE00000584531","2","70","Tyrosine to STOP",{"$nulls":4},"ATCCTCTTCCACCGAAACAGCCAGCACTATACTCTAGACTTCCTCTCGCCAAAAACCTTCC","Yes",{"$nulls":12},"Limb deformity. Shortening and angular deformity of hindlimbs with extra digits present in some cases. Deformity affects mouse mobility.   Previously described homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","10","8",null,"No","2012-09-14","Cryopreserved sperm"]
[7336,"ENU17NIH:050b","C57BL/6JAnu-Zfp318<m1Anu>/AnuApb","C57BL/6JAnu-Zfp318<m1Anu>/AnuApb","Recessive","zinc finger protein 318","Zfp318","Unknown","2610034E08Rik, D530032D06Rik, TZF ","MGI:1889348","zinc finger protein 318; mutation 1, The Australian National University","Zfp318<m1Anu>","MGI:5563395","17","ENSMUSG00000015597","ENSMUST00000113481","Zfp318-001","4040","4148","T to C","ENSMUSE00000695799","10","1347","Isoleucine to Threonine",{"$nulls":4},"TGAAGTTGGAAAGGCAAAGCCCATCAAAATCAAGCTTTCTGGAAAAACTGTCATTGCACAC",{"$nulls":13},"Abolished IgD expression on marginal zone B cells, decreased IgD on follicular B cells, and increased IgM, but only slightly decreased the percentage of B cells and did not decrease expression of other maturation markers CD21, CD23, or CD62L.Gene is highly expressed in testis and male mice homozygous for a null allele seem to have reduced fertility.","Normal","C57BL/6JAnu","Yes","Unknown","Yes","Yes","Yes","Yes","No","Good","3","G7","Usually het x het but have used homozygous males","No","2013-05-14","Cryopreserved sperm"]
[7558,"ENU27:009:RASGRP1:B6","C57BL/6NCrlAnu-Rasgrp1<m2Anu>/AnuApb","C57BL/6NCrlAnu-Rasgrp1<m2Anu>/AnuApb","Recessive","RAS guanyl releasing protein 1","Rasgrp1","Unknown",null,"MGI:1314635","RAS guanyl releasing protein 1; mutation 2, The Australian National University","Rasgrp1<m2Anu>","MGI:5563430","2","ENSMUSG00000027347","ENSMUST00000102534","Rasgrp1-001","1976","2268","T to C","ENSMUSE00000295129","16","659","Lysine to Arginine",{"$nulls":4},"CATCATGCTCCTCGGAGTGTCCTCCCAGAAAATTTCAGTTCGGCTGAAGAGGACTGTTGCC",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2013-12-19","Cryopreserved sperm"]
[7968,"iNOSΔ","B6.129P2-Nos2<tm1Lau>/JAusbAnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach","Nos2<tm1Lau>","MGI:1857228","11",{"$nulls":28},"Abnormal surfactant physiology:*Following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice.*Following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice.Abnormal circadian rhythm:*Mice display a more pronounced diurnal variation of sleep-wake activity.Abnormal sleep pattern:*Mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals.*Mice display a more pronounced diurnal variation of sleep-wake activity.*Mice spend less time in non-REM sleep during the dark phase.*During the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration.Abnormal brain wave pattern:*During non-REM sleep the absolute value of slow wave activity is increased.Abnormal inflammatory response:*Unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls.      Decreased inflammatory response:      *Fever in response to LPS injection is partially reduced compared to wild-type controls.      *The fever response to LPS is initiated but not sustained.      *However, fever in response to turpentine injection is not different from controls.",null,"unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-09-17","Cryopreserved sperm, Embryo"]
[7969,"HSPE Tg x HIP-Cre","C57BL/6-Gt(ROSA)26Sor<tm1(UBC-HPSE)Anu> Tg(INS-cre)2Rms/AnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",{"$nulls":3},"6",{"$nulls":16},"transgene insertion 2, Robyn M Slattery","human insulin promoter",{"$nulls":10},"Unknown",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2015-09-18","Cryopreserved sperm"]
[7971,"Srsf7-flox","B6;129-Srsf7<tm1>/MarpApb",null,"Recessive","serine/arginine-rich splicing factor 7","Srsf7",null,"9430065L19Rik, 9G8, NX-96, Sfrs7","MGI:1926232",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-09-22"]
[7979,"Nrp1:Cre/EGFP","C57BL/6-Tg(Nrp1-cre/Egfp)",null,"Dominant",{"$nulls":25},"Cre recombinase/EGFP","Nrp1","low",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-10-09","Cryopreserved sperm"]
[7982,"F/F:STAT3-SA , BJ33","B6.129-IL6st<tm1Ern> Stat3<tm1Dnl>/MarpApb",null,"Recessive","interleukin 6 signal transducer","Il6st","Normal","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes"]
[7986,"Recql4 R347*","C57BL/6JAnu-Recql4<m2Anu>/AnuApb",null,"Recessive","RecQ protein-like 4","Recql4","Unknown",null,"MGI:1931028","Recql4 R347*","Recql4 R347*",null,"15","ENSMUSG00000033762","ENSMUST00000036852","Recql4-201","1039","1122","G to A","ENSMUSE00000237138","5","347","Arginine to STOP",{"$nulls":4},"CAGCTTCCCTAGACAGAGGGAACTATATTCGACTCAACATGAAAAACAAACGCTTTGTACG","Unknown",{"$nulls":12},"Unknown as none recovered at time of submission","Appear normal and fertile","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","2 to C57BL/6","1","PM/+ to either PM/+ or WT","No","2015-10-27","Cryopreserved sperm"]
[7988,"PTX3 knockout","B6.129-Ptx3<tm1Mant>",null,"Semi-dominant","pentraxin related gene","Ptx3",null,"pentraxin 3, TSG-14","MGI:104641","pentraxin related gene; targeted mutation 1, Alberto Mantovani","Ptx3<tm1Mant>","MGI:2675283","3",{"$nulls":28},"Reduced female fertility:\t• homozygotes display a severe defect in female fertilityLung inflammation:• lungs from Aspergillus fumigatus infected homozygotes display a massive inflammatory response, the presence of hyphae and numerous, mostly extracellular, conidia, relative to similarly infected wild-type controlsAbnormal T-helper 1 physiology:• upon challenge with Aspergillus fumigatus, homozygotes fail to develop an appropriate TH1-type response and display a cytokine profile skewed towards a TH2-type response, as revealed by reduced IFN-gamma and IL-12 levels and increased IL-4 levels in mutant lungsAbnormal macrophage physiology:• homozygotes exhibit defective recognition of Aspergillus fumigatus conidia by alveolar macrophagesImpaired macrophage phagocytosis:• in vitro, the ability of mutant alveolar macrophages to ingest and kill resting Aspergillus fumigatus conidia is impaired relative to wild-type macrophages","Normal.","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-11-03","Cryopreserved sperm"]
[7993,"Rag2","C.129S6-Rag2<tm1Fwa>/UcApb","C.129S6-Rag2<tm1Fwa>/UcApb","Recessive","recombination activating gene 2","Rag2","Normal","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2",{"$nulls":28},"Homozygous mice exhibit total inability to initiate V(D)J rearrangement and fail to generate mature T or B lymphocytes.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-11-18","Cryopreserved sperm"]
[7996,"SMB","B6.129P2-Smg1<Gt(AG0297)Wtsi>",null,"Dominant","SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)","Smg1","Unknown","SMG-1, ATX","MGI:1919742","SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans); gene trap AG0297, Wellcome Trust Sanger Institute","Smug<Gt(AG0297)Wtsi>","MGI:3876748","7",{"$nulls":28},"Early embryonic lethal","Premature death:• due to high tumor incidenceIncreased tutor incidence:• in various organsIncreased lymphoma incidence:• predominantly B cell of follicular center originIncreased B cell derived lymphoma incidence:• of follicular center originIncreased lung adenocarcinoma incidence:• papillary adenocarcinoma in the lungAbnormal basicranium angle:• the angle formed by the plane of the mandible to the plane of the cranial base is decreased compared to in wild-type micePrognathiaAbnormal tooth morphology:• over-grownAbnormal tooth development:• producing over-grown teethIncreased body sizeIncreased body weightIncreased body lengthEnlarged spleenDecreased circulating interleukin-1 beta levelIncreased circulating interleukin-6 levelChronic inflammation:• low level inflammation that progresses to chronic inflammation• mainly in the kidney and lungEnlarged liverHepatic steatosisAbnormal kidney morphologyAbnormal basicranium angle:• the angle formed by the plane of the mandible to the plane of the cranial base is decreased compared to in wild-type mice","C57BL/6N","No","No","Yes","No","No","Yes","No","Good","20",null,"Het x WT","No","2015-11-20","Cryopreserved sperm"]
[8001,"Y-RFP ; Ddx3y_cl.330_RFP","129-Ddx3y<tm2Kalp>/330KalpApb","Yrfp","Semi-dominant","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked","Ddx3y","Normal",null,"MGI:1349406",{"$nulls":3},"Y",{"$nulls":28},"Normal","Most tissues express the mKate2 red fluorescent protein gene. There is some variation in expression between tissues.","129S1/Sv1mJ ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-12-04","Cryopreserved sperm"]
[8000,"Y-RFP ;Ddx3y_cl.106_RFP","129-Ddx3y<tm2Kalp>/106KalpApb","Yrfp","Semi-dominant","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked","Ddx3y","Normal",null,"MGI:1349406",{"$nulls":3},"Y",{"$nulls":28},"Normal","Most tissues express the mKate2 red fluorescent protein gene. There is some variation in expression between tissues.","12951/Sv1mJ ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-12-04","Cryopreserved sperm"]
[8012,"ChR2","B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/JAnu",null,"Dominant",{"$nulls":25},"transgene insertion 18, Guoping Feng","Thy1",{"$nulls":10},"Neurons expressing EYFP show no signs of degeneration or altered morphology",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-12-16","Cryopreserved sperm"]
[8011,"Rag2 / IL2rg KO / hGM/IL3","C;129SV4-Rag2<tm1.1Flv> Csf2/Il3<tm1.1(CSF2,IL-3)Flv> Il2rg<tm1.1FLv>/J",null,"Recessive","Il2rg",{"$nulls":7},"Unknown"]
[8007,"Fgf8flox","B6.Cg-Fgf8<tm1Moon>/DunwApb",null,"Recessive","fibroblast growth factor 8","Fgf8","Unknown","Aigf, Fgf-8","MGI:99604","fibroblast growth factor 8; targeted mutation 1, Anne M Moon","Fgf8<tm1Moon>","MGI:2686864","19",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-12-09","Cryopreserved sperm"]
[4746,"Rag:KK","B6.Cg-H2<k> Rag1<tm1Mom>/AnuApb",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.",null,"C57BL/10.BR x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"18",null,"No","2009-04-27","Cryopreserved sperm"]
[8018,"ENU37:G2","ANU:ENU37:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2016-01-07","Cryopreserved sperm"]
[8020,"ICExiNOSxRKO/BL6","B6;129S2-Casp1<tm1Sesh> Ifngr1<tm1Agt> Nos2<tm1Mrl>/AnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, Nos2a, NOS-II","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, Merck Research Laboratory","Nos2<tm1Mrl>","MGI:2158791","11"]
[8025,"Roquin fl","B6.Cg-Rc3h1<tm1.1Cgv>/Anu",null,"Recessive","RING CCCH (C3H) domains 1","Rc3h1","Unknown","5730557L09Rik, roquin","MGI:2685397","RING CCCH (C3H) domains 1; targeted mutation 1.1, Carola Vinuesa","Rc3h1<tm1.1Cgv>","MGI:5508920","1",{"$nulls":29},"No phenotypic analysis","C57BL/6","Yes","Yes","Yes","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2016-02-16"]
[7625,"Srsf7-KO","B6NTac;B6N-A<tm1Brd> Srsf7<tm1a(EUCOMM)Wtsi>/WtsiMarp",null,"Dominant","serine/arginine-rich splicing factor 7","Srsf7",null,"9430065L19Rik, 9G8, NX-96, Sfrs7","MGI:1926232","serine/arginine-rich splicing factor 7; targeted mutation 1a, Wellcome Trust Sanger Institute","Srsf7<tm1a(EUCOMM)Wtsi>","MGI:4433826","17",{"$nulls":28},"Embryonic lethal","Uncharacterised","C57BL/6NTacMarp","No","No","Yes","No","No","Yes","No","Good","na","na",null,"No","2014-03-24","Cryopreserved sperm"]
[8028,"ENU34:001:Zfp318","C57BL/6NCrlAnu-Zfp318<m2Anu>/AnuApb",null,"Recessive","zinc finger protein 318","Zfp318",null,"2610034E08Rik, D530032D06Rik, TZF","MGI:1889348",{"$nulls":3},"17","ENSMUSG00000015597","ENSMUST00000113481","Zfp318-001","3301","3409","T to C","ENSMUSE00001294148","7","1101","Phenylalanine to Leucine",{"$nulls":4},"AAGACTGCAATACCACCTGTGGGACCATGTTTGACTTCTTCACCCATATGCACAATAAGAA",{"$nulls":13},"Increased expression of IgM and decreased expression of IgD on mature B cells",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-03-17","Cryopreserved sperm"]
[8032,"CD11c-cre x Atg7","C57BL/6-Atg7<tm1Tchi> Tg(Itgax-cre)1-1Reiz/Wehi",null,"Recessive","autophagy related 7","Atg7","Normal","1810013K23Rik, Apg7l","MGI:1921494","autophagy related 7; targeted mutation 1, Tomaki Chiba","Atg7<tm1Tchi>","MGI:3587769","6",{"$nulls":16},"transgene insertion 1-1, Boris Reizis","mouse integrin alpha X (Cd11c)",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-03-31","Cryopreserved sperm"]
[8033,"Foxn1-cre x Atg5 loxp","B6.129-Atg5<tm1Myok> Foxn1<tm3(cre)Nrm>/Wehi",null,"Recessive","autophagy related 5","Atg5","Normal","2010107M05Rik, 3110067M24Rik, Apg5l, Paddy","MGI:1277186","autophagy related 5; targeted mutation 1, Minesuke Yokoyama","Atg5<tm1Myok>","MGI:3663625","10",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-04-04","Cryopreserved sperm"]
[8033,"Foxn1-cre x Atg5 loxp","B6.129-Atg5<tm1Myok> Foxn1<tm3(cre)Nrm>/Wehi",null,"Recessive","forkhead box N1","Foxn1","Normal","D11Bhm185e, Hfh11, whn","MGI:102949","forkhead box N1; targeted mutation 3, Nancy R Manley","Foxn1<tm3(cre)Nrm>","MGI:3760775","11"]
[8042,"gp130Y757F x sgp130Fc","B6.129- Il6st<tm1Ern> Tg(Hbb-sgp130Fc)/MarpApb",null,"Recessive",null,null,"Nil",{"$nulls":5},"1",{"$nulls":15},"No"]
[8043,"B6:Thy1.1","B6.Cg-Thy1<a>/AnuApb",null,"Recessive","thymus cell antigen 1, theta","Thy1",null,"CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":28},"Normal",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-04-15","Cryopreserved sperm"]
[4988,"ATM 7271 T⇒G ; Adonis","C.B6-ATM<tm1Gct> ",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Normal","C030026E19Rik","MGI:107202","targeted mutation 1, Georgia Chenevix-Trench","ATM<tm1Gct>",null,"9",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"No",{"$nulls":12},"Infertile. Increased sensitivity to ionizing radiation. Immune deficiencies. Increased susceptability to lymphoid tumours","Normal","BALB/c","Yes","No","Yes","Yes","No","Yes","Yes","Good","8",null,null,"No","2010-01-28","Cryopreserved sperm"]
[8052,"Thor:Ins","Folr4:Ins",null,"Recessive","IZUMO1 receptor, JUNO","Izumo1r",null,"0910001L11Rik, Folbp3, Folr4, Juno","MGI:1929185",{"$nulls":3},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-05-23","Cryopreserved sperm"]
[7716,"Fras1<bl>","B6.Cg-Fras1<bl>/MarpApb",null,"Dominant","Fraser syndrome 1 homolog (human)","Fras1","Unknown","bl, E130113P14Rik, mKIAA1500","MGI:2385368","Fraser syndrome 1 homolog (human); blebbed","Fras1<bl>","MGI:1856691","5",{"$nulls":28},"Embryonic lethal.• most homozygotes die before birth• however, a few reach adulthood with no signs of skin blisteringSyndactyly:• adult homozygotes exhibit distal limb defects, such as syndactyly of the hind limbs.Clubfoot:• homozygotes may exhibit clubbed feet or hands.Abnormal kidney development:• at E11.5-E15.5, homozygotes show a range of defects in metanephric kidney development, followed by degeneration of early metanephric rudiments• however, 20% of homozygous mutant embryos display a relatively normal metanephric development, including formation of glomeruli by E15.5Abnormal metanephric mesenchyme morphology:• by E13.5-E14.5, the metanephric mesenchyme is poorly differentiated with many cells containing pyknotic nuclei suggestive of apoptosis.Increased metanephric mesenchyme apoptosis:• by E13.5-E14.5, many cells contain pyknotic nuclei suggesting apoptosis.Abnormal metanephros morphology:• at E11.5-E15.5, some homozygotes display small and pooorly differentiated metanephroi, followed by degeneration of early metanephric rudiments.Delayed kidney development:• by E13.5-E14.5, mutant kidneys appear developmentally delayed and are much smaller than those of wild-type mice.Small kidney:• at E13.5-E14.5Absent kidney:• homozygotes may lack one or both kidneys.Kidney cysts:• 2 of 146 live-born survivors display grossly cystic kidneysSingle kidney:• homozygotes may exhibit only one kidney.• 20 of 146 live-born survivors display complete unilateral renal agenesis.Abnormal ureteric bud morphology:• at E11.5-E12.5, homozygous mutant embryos exhibit a dilated uteric bud.Impaired branching involved in ureteric bud morphogenesis:• at E11.5-E12.5, homozygous mutant embryos display reduced ureteric bud branching relative to wild-type embryos.Microphthalmia:• homozygotes display reduced eyesCryptophthalmos:• adult homozygotes display cryptophthalmosAbnormal hair growth:• homozygotes often display abnormal hair development between the eyesBleb:• blebs are still visible at birthFetal bleb:• at E14.5, homozygotes display prominent blebs over the rump and smaller blebs over the head and forelimb• however, homozygotes that survive and are live-born show no signs of skin blistering.","wildtype","C57BL/6","No","No","Yes","No","No","Yes","No","Good","7","4",null,"No","2014-07-02","Cryopreserved sperm"]
[8055,"Sox2-GiDREADD","B6(Cg).129-Soz2<tm1(cre/ERT2)Hoch> Gt(ROSA)26Sor<tm1(CAG-CHRM4*,-mCitrine)Ute>/JAusb",null,"Recessive","SRY (sex determining region Y)-box 2","Sox2",null,"lcc, Sox-2, ysb","MGI:98364","SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger","Sox2<tm1(cre/ERT2)Hoch>","MGI:5295990","3",{"$nulls":28},"Bi-transgenic mice will enable expression of target gene (i.e. DREADD receptor) in sox2-expressing cells upon tamoxifen administration, which will persist as the cells differentiate and mature.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-06-03"]
[8064,"ENU32:002","ENU32:002",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"decreased %CD4 T cells, increased %CD8 T cells and high CD44 MFI on CD4 and CD8 T cells in peripheral blood.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5",null,"No","2016-07-05","Cryopreserved sperm"]
[8063,"ENU32:020:Ebf1","C57BL/6NCrlAnu-Ebf1<m2Anu>/AnuApb",null,"Dominant","early B cell factor 1","Ebf1","Unknown","O/E-1, Olf1, Olf-1","MGI:95275",{"$nulls":3},"11","ENSMUSG00000057098","ENSMUST00000081265","Ebf1-001",{"$nulls":7},"44924576","10",null,null,"AAGGGACACCAGGCAGATTCATCTACACAGGTAAGCGTGCCTGCAGATGGGAACCACAGA",{"$nulls":13},"Homozygous lethal, unknown at what stage.","Abnormal and reduced numbers of B cells","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"5",null,"No","2016-07-05","Cryopreserved sperm"]
[8066,"ENU36:034:Itpkb","C7BL/6NCrlAnu-Itpkb<m1Anu>/AnuApb",null,"Recessive","inositol 1,4,5-trisphosphate 3-kinase B","Itpkb","Unknown","1110033J02Rik, E130307H12Rik","MGI:109235",{"$nulls":3},"1",{"$nulls":28},"Mice lack T cells and have abnormal B cells in blood.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"3",null,"No","2016-07-05","Cryopreserved sperm"]
[8069,"Ai14D","B6.Cg-Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/JAnuApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 14, Hongkui Zeng","Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>","MGI:3809524","6",{"$nulls":29},"No abnormal phenotype detected:• mice are viable and fertile; used for cre reporter expression analysis","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-07-05","Cryopreserved sperm"]
[8078,"SJL Jax","B6(Cg).SJL-Ptprc<a>/JAnuApb",null,"Recessive",{"$nulls":37},"T cells express the Ptprc<a> allele instead of Ptprc<b> allele usually carried by Lymphocytes isolated from C57BL/6 mice.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8","1","a x a","No","2016-07-25","Cryopreserved sperm"]
[8075,"Adar1E861A/E861A Ifih1-/-","B6.129-Adar1<E861A> Ifih1<tm1.1Cln>/Apb",null,"Recessive","adenosine deaminase, RNA-specific","Adar",null,"ADAR1, Adar1p110, Adar1p150, mZaADAR","MGI:1889575","Adar1E861A/E861A Ifih1-/-",null,null,"3",{"$nulls":28},"Adar1E861A/E861A Ifih1-/- and viable, fertile, and largely normal. They are smaller at birth and weaning but recover by 12 weeks.","Heterozygous animals are normal and fertile for both alleles individually and as compound mutants.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-07-14","Cryopreserved sperm"]
[8079,"SJL NCrl","B6(Cg).SJL-Ptprc<a>/NCrlAnuApb",null,"Recessive",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","T cells express the Ptprc<a> allele instead of Ptprc<b> allele usually carried by Lymphocytes isolated from C57BL/6 mice.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9","2","a x a","No","2016-07-25","Cryopreserved sperm"]
[8082,"ASD661:Pique:7","C57BL/6NCrlAnu-Zfr2<em1Anu>/AnuApb",null,"Recessive","zinc finger RNA binding protein 2","Zfr2","Unknown","2010013I23Rik, 9130206N08Rik","MGI:2143792",{"$nulls":3},"10",{"$nulls":28},"Unknown at this stage",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","Poor",{"$nulls":3},"No","2016-08-11","Cryopreserved sperm"]
[8088,"RHBDF1 KO","C57BL/6-Rhbdf1<em1Arl>/MarpApb",null,"Recessive","rhomboid 5 homolog 1","Rhbdf1","Unknown","Dist, Dist1, Egfr-rs","MGI:104328",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-08-24"]
[8094,"ENU28:008:Slc1a5","C57BL/6NCrlAnu-Slc1a5<m1Anu>/AnuApb",null,"Recessive","solute carrier family 1 (neutral amino acid transporter), member 5","Slc1a5","Unknown","ASCT2","MGI:105305",{"$nulls":3},"7",{"$nulls":9},"Unknown to Unknown",{"$nulls":20},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2016-09-05","Cryopreserved sperm"]
[8097,"Cliff79B-A4","C57BL/6NCrlAnu-Cd79b<em2Anu>/AnuApb",null,"Recessive","CD79B antigen","Cd79b","Unknown","B29, Igb, Igbeta, Ig-beta","MGI:96431",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-07","Cryopreserved sperm"]
[8103,"Kca3.1","B6.129-Kcnn4<tm1Jemn>/Apb",null,"Recessive","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4","Kcnn4","Unknown","IK1, IKCa1, KCa3.1, mIKCa1, SK4","MGI:1277957","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, James E Melvin","Kcnn4<tm1Jemn>","MGI:3521668","7",{"$nulls":28},"Increased parotid gland size:• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seenAbnormal hematopoietic system physiology:• A23187-stimulated, clotrimazole sensitive uptake of 86Rb into red blood cells is nearly eliminated in homozygous mutants and A23187 has no effect on the tonicity at which 50% of mutant red cells lyseAbnormal T cell physiology:• shrinkage of T lymphocytes induced by the Ca2+ ionophore, ionomycin, is greatly reduced",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-15","Cryopreserved sperm"]
[8104,"Cliff79B-A2","C57BL/6NCrlAnu-Cd79b<em5Anu>/AnuApb",null,"Recessive","CD79B antigen","Cd79b","Unknown","B29, Igb, Igbeta, Ig-beta","MGI:96431",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-21","Cryopreserved sperm"]
[8115,null,"Swiss",null,"Dominant",{"$nulls":37},"Background, outbred strain",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-10-26","Cryopreserved sperm"]
[8108,"gp130Y757F x Nlrp3 KO","B6.129- Il6st<tm1Ern> Nlrp3<tm1Flv>/MarpApb",null,"Recessive","NLR family, pyrin domain containing 3","Nlrp3","Nil","Cias1, cryopyrin, Mmig1, NALP3, Pypaf1","MGI:2653833","NLR family, pyrin domain containing 3; targeted mutation 1, Richard A Flavell","Nlrp3<tm1Flv>","MGI:3686871","11",{"$nulls":15},"No"]
[8112,"Ets1Flp","C57BL/6-Ets1<tm1.1Pjh>/Pjh",null,"Recessive","E26 avian leukemia oncogene 1, 5' domain","Ets1","Normal","Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1, vs","MGI:95455","E26 avian leukemia oncogene 1, 5' domain #198Flp#20","Ets1#198Flp#20",null,"9",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-10-10","Cryopreserved sperm"]
[8118,null,"ASD565:Hummels:F1#12:Mertk:Timd4 #2",null,"Recessive","T cell immunoglobulin and mucin domain containing 4","Timd4",null,"B430010N18Rik, Tim4, TIM-4","MGI:2445125",{"$nulls":3},"11"]
[8121,"Foxb1<cre>","B6.129X1-Foxb1<tm1(cre)Gabo>/Anu",null,"Dominant","forkhead box B1","Foxb1",null,"C43, Fkh5, Foxb1a, Foxb1b, Hfh-e5.1, Mf3, TWH","MGI:1927549","forkhead box B1; targeted mutation 1, Gonzalo Alvarez-Bolado","Foxb1<tm1(cre)Gabo>","MGI:3772366","9",{"$nulls":28},"No phenotypic analysis",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-10-27","Cryopreserved sperm"]
[8124,"Er81 fl:Lhx6-Cre","B6.129-Etv1<tm1Wds> Tg(Lhx6-icre)1Kess/Anu",null,"Recessive","ets variant 1","Etv1","Unknown","ER81, Etsrp81","MGI:99254","ets variant 1; targeted mutation 1, William D Snider","Etv1<tm1Wds>","MGI:2663693","12",{"$nulls":16},"transgene insertion 1, Nicoletta Kessaris","LIM homeobox protein 6",{"$nulls":13},"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-10-28"]
[8127,"Nkx2.1-CreER","B6.129-Nkx2-1<tm1.1(cre/ERT2)Zjh>/JAnu",null,"Dominant","NK2 homeobox 1","Nkx2-1",null,"T/EBP, thyroid-specific enhancer-binding protein, thyroid transcription factor-1, tinman, Titf1, Ttf-1","MGI:108067","NK2 homeobox 1; targeted mutation 1.1, Z Josh Huang","Nkx2-1<tm1.1(cre/ERT2)Zjh>","MGI:5302534","12",{"$nulls":28},"Unknown",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-10-28"]
[8128,"ENU18:021:Baff","B6(Cg)-Tnfsf13b<m2Anu>/AnuApb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 13b","Tnfsf13b",null,"BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4","MGI:1344376",{"$nulls":3},"8",{"$nulls":28},"Block in B cell development",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2016-10-31","Cryopreserved sperm"]
[8129,"Sst-cre","STOCK Sst<tm2.1(cre)Zjh>/JAnu",null,"Recessive","somatostatin","Sst",null,"preprosomatostatin, Smst, SOM, SRIF","MGI:98326","somatostatin; targeted mutation 2.1, Z Josh Huang","Sst<tm2.1(cre)Zjh>","MGI:4838416","16",{"$nulls":28},"No abnormal phenotype detected:\t• homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities",null,"Mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-11-01","Cryopreserved sperm"]
[8135,"Sm22-rtTA","FVB/N-Tg(Tagln-rtTA)E1Jwst",null,"Dominant",{"$nulls":25},"transgene insertion E1, James West","murine smooth muscle-specific SM22-alpha",{"$nulls":10},"Same as wildtype","Same as wildtype","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-11-15","Cryopreserved sperm"]
[8140,"Pvr KO","B6N.129S2-Pvr<tm1Gbn>/JAnu",null,"Recessive","poliovirus receptor","Pvr","Nil","3830421F03Rik, CD155, D7Ertd458e, mE4, necl-5, Taa1, Tage4","MGI:107741","poliovirus receptor; targeted mutation 1, Gunter Bernhardt","Pvr<tm1Gbn>","MGI:3719436","7",{"$nulls":28},"Decreased IgA level:\t• following oral immunization with cholera toxin, IgA levels are decreased relative to wild-type miceDecreased IgG level:\t• following oral immunization with cholera toxin, IgG1, IgG2a and IgG2b levels are decreased relative to wild-type miceDecreased IgG1 level.Decreased IgG2a level.\tDecreased IgG2b level.Abnormal response to infection:\t• following oral immunization with cholera toxin, IgA, IgG1, IgG2a and IgG2b levels are decreased relative to wild-type mice",null,"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2016-11-24","Cryopreserved sperm"]
[8143,"Alcam KO","B6.129(FVB)-Alcam<tm1Jawe>/JAnu",null,"Recessive","activated leukocyte cell adhesion molecule","Alcam","Nil","BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1","MGI:1313266","activated leukocyte cell adhesion molecule; targeted mutation 1, Joshua A Weiner","Alcam<tm1Jawe>","MGI:3056579","16",{"$nulls":28},"Abnormal retina morphology:\t• in 75% of mutant eyes retinal dysplasia is seen with finger like projections of photoreceptor cells protruding into the outer nuclear layer and/or invagination of the retina without disrupting the cell layers• dysplasia can be detected on P1Abnormal photoreceptor outer segment morphology:\t• photoreceptor outer segments appear elongated and disorganizedAbnormal retinal ganglion layer morphology:\t• axons are loosely bundled and occasionally have aberrant trajectories however all exit the optic disc normallyAbnormal motor neuron innervation pattern:\t• motor neurons are loosely bundled with some axons exiting the bundles at a right angle to the adjacent nerve and ending blindly or forming bridges to neighboring bundles",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-11-24","Cryopreserved sperm"]
[8149,"NODCrisprGzmA","NOD-Gzma<em1Tcb>",null,"Recessive","granzyme A","Gzma","Unknown","BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1 ","MGI:109266",{"$nulls":3},"13",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-12-11","Cryopreserved sperm"]
[8154,"NODlga","NOD-Ifnlr1<em13Tcb>",null,"Recessive","Interferon lambda receptor 1","Ifnlr1","Unknown","CRF2-12, IFNLR1, Il28ra","MGI:2429859",null,"em13Tcb",null,"4",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-12-16","Cryopreserved sperm"]
[8159,"NODlga","NOD-Ifnlr1<em13Tcb> Ifngr1<em15Tcb> Ifnar1<em16Tcb>",null,"Recessive","Interferon alpha receptor 1","Ifnar1","Unknown","Ifar, IFN-alpha/betaR, Ifrc","MGI:107658",null,"em16Tcb",null,"16"]
[8160,null,"ENU36:080:Car2",null,"Recessive","carbonic anhydrase 2","Car2","Unknown","CAII, CA II, Car-2, Ltw-5, Lvtw-5","MGI:88269",{"$nulls":3},"3","ENSMUSG00000027562","ENSMUST00000029078.8","Car2-001","140","465","T to A","ENSMUSE00000371047","2","47","Leucine to Glutamine",{"$nulls":4},"TGCCCAGCATGACCCTGCCCTACAGCCTCTGCTCATATCTTATGATAAAGCTGCGTCCAAG",{"$nulls":13},"Red blood cells are resistent to lysis",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-12-22","Cryopreserved sperm"]
[8150,"NODCrisprGzmA","NOD-Gzma<em2Tcb>",null,"Recessive","granzyme A","Gzma","Unknown","BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1","MGI:109266",null,"em2Tcb",null,"13",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-12-15","Cryopreserved sperm"]
[8161,"Casp1 KO","B6.129S2-Casp1<tm1Flv>/JAnu",null,"Recessive","caspase 1","Casp1","Nil","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544","caspase 1; targeted mutation 1, Richard Flavell","Casp1<tm1Flv>","MGI:2158744","9",{"$nulls":28},"Mice lack expression of interleukin-1 converting enzyme (or caspase-1) and therefore cannot proteolytically cleave interleukin 1β and interleukin 18 into active mature peptides. ","unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","13",null,null,"Yes","2017-01-23"]
[8178,"ENU37:055:Casp4","C57BL/6NCrlAnu-Casp4<m1Anu>/AnuApb",null,"Recessive","caspase 4, apoptosis-related cysteine peptidase","Casp4","Unknown","Casp11, Caspase-11, ich-3","MGI:107700",{"$nulls":3},"9",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-03","Cryopreserved sperm"]
[8175,"Ccnf<S621G>","Ccnf<S621G>",null,"Recessive","cyclin F","Ccnf","Unknown","CycF, Fbxo1","MGI:102551",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-01-30"]
[7679,"ENU7PMH:130:B10:B6-ATkk:G9 ; Krusty:3A9:H2<k>","B6.Cg-H2<k> Ndfip1<kru> Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","Nedd4 family interacting protein 1","Ndfip1","Unknown","0610010M22Rik","MGI:1929601","krusty","kru",null,"18","ENSMUSG00000024425","ENSMUST00000025293","Ndfip1-201",{"$nulls":7},"38612084","5",null,null,"TCTCTAATTAAGTGGATCCTTATTGTCAGGGTAAGTTGCATAGCAGAGAACAGATTGTGA",null,"transgene insertion 1, Mark M Davis","TCR",null,"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Spontaneous mast cell-rich dermatitis with median onset age 90 d, followed by weight loss and premature mortality at a median age of 160 d. This was accompanied by lymph- adenopathy, splenomegaly, increased CD86 and CD23 activation markers on B cells, expansion of the activated/memory subset of CD4<+> and CD8<+> T cells, greatly elevated serum IgE, and for- mation of a prominent population of IL-4<+> and IFN-γ<+> CD4<+>.Autonomous accumulation of CD4<+> effector cells not corrected by normal Foxp3<+> cells.Absence of Ndfip1 did not result in spontaneous activation of naïve CD4+ T cells. Naive Ndfip1<kru/kru> Tg(TcrHel3A9) CD4<+> transferred to congenic B10.BR CD45 mice injected with hen egg lysozyme. After 6 days continued to increase in frequency, a further 4 fold over d3 levels, whereas WT cells decreased 5 fold from d3 levels.",null,"C57BL/6JSfdAnu x B10.BR-H2<k2>","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-05-13","Cryopreserved sperm"]
[8180,"hTAP1/hTAP2 BAC Tg ET18","C57BL/6J-Tg(hTAP1/hTAP2)/18MarpAnu",null,"Recessive",{"$nulls":25},"human transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / human transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-07","Cryopreserved sperm"]
[8190,"BigMac","BigMac",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-16","Cryopreserved sperm"]
[8188,"ENU33:009:Clk1","C57BL/6NCrlAnu-Clk1<m1Anu>/AnuApb",null,"Recessive","CDC-like kinase 1","Clk1","Unknown","Clk1, STY","MGI:107403",{"$nulls":3},"1","ENSMUSG00000026034","ENSMUST00000034868.13","Clk1-001","971","1118","T to C","ENSMUSE00001227858","9","324","Aspartic acid to Glycine",{"$nulls":4},"TATAGTAAATCCAGATATTAAAGTGGTGGACTTTGGAAGTGCAACATATGATGATGAACAC",{"$nulls":13},"FACS phenotype: Increase IgM and decreased IgD on mature B cells.","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-02-16","Cryopreserved sperm"]
[8191,"B6.Cg-Tg(Thy1-YFP)HJrs/J  x B6.Cg-Sgshmps3a/Ldru","B6.Cg-Sgsh<mps3a> Tg(Thy1-YFP)HJrs/J",null,"Recessive","N-sulfoglucosamine sulfohydrolase (sulfamidase)","Sgsh",null,"4632406A19Rik, sulphamidase","MGI:1350341","N-sulfoglucosamine sulfohydrolase (sulfamidase); mucopolysaccharidosis IIIA","Sgsh<mps3a>","MGI:2151181","11",{"$nulls":16},"transgene insertion H, Joshua R Sanes","Thy1, thymus cell antigen 1, theta, mouse, laboratory",{"$nulls":10},"These thy1-YFP-H transgenic mice express yellow fluorescent protein at high levels in motor and sensory neurons, as well as subsets of central neurons. Axons are brightly fluorescent all the way to the terminals. This line provides a strong and specific \"Golgi-like\" vital marker for several widely studied neuronal subsets, with minimal labeling of nearby axons. These mice carry a spontaneous mutation at the  Sgsh  locus characterized by scruffy coat, hunched posture, and reduced activity, and corneal opacity as a result of extensive lysosomal accumulation of heparin sulfate most prominently in neuronal tissue and liver and, to a lesser degree, in the spleen. ","These thy1-YFP-H transgenic mice express yellow fluorescent protein at high levels in motor and sensory neurons, as well as subsets of central neurons. Axons are brightly fluorescent all the way to the terminals. This line provides a strong and specific \"Golgi-like\" vital marker for several widely studied neuronal subsets, with minimal labeling of nearby axons. They do not have a Sanfilippo phenotype.","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-02-17","Cryopreserved sperm"]
[8194,"ASD552:Cahill:V203I","C57BL/6NCrlAnu-Ikbkb<em1Anu>/3AnuApb",null,"Recessive","inhibitor of kappaB kinase beta","Ikbkb","Unknown","IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta","MGI:1338071",{"$nulls":3},"8",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-20","Cryopreserved sperm"]
[650,"Fat Aussie","NOD-Alms1<foz>",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Nil",null,"MGI:1934606","fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"No",{"$nulls":12},"Hyperglycemia: female mice are diabetic by 200 days of age.Increased circulating insulin level: female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type).Insulin resistance: female mice develop insulin resistance by 200 days of age.Increased eating behaviour: mutants eat more than wild-type.Abnormal hepatocyte morphology: mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells.Enlarged liver: mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g).Increased liver weight: liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g).Hepatic steatosis: chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis.Liver fibrosis: mutant livers show pericellular and pericentral fibrosis.",null,"NOD","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2007-04-25"]
[8205,"hTAP1/hTAP2 BAC Tg ET20","C57BL/6J-Tg(hTAP1/hTAP2)/20MarpAnu",null,"Recessive",{"$nulls":25},"human transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / human transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-02","Cryopreserved sperm"]
[8207,"Tap1/Tap2 KO x Tg(hTAP1/hTAP2) BAC #2","C57BL/6J-Tap1/Tap2<em1Anu> Tg(hTAP1/hTAP2)20/2MarpAnu",null,"Recessive","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","Tap1","Nil","Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1","MGI:98483",{"$nulls":3},"17",{"$nulls":16},"human transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / human transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-02","Cryopreserved sperm"]
[8206,"Tap1/Tap2 KO ET33","C57BL/6J-Tap1/Tap2<em1Anu>/33MarpAnu",null,"Recessive","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","Tap1","Nil","Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1","MGI:98483",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-02","Cryopreserved sperm"]
[8214,"DEREG","C57BL/6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax",null,"Dominant",{"$nulls":25},"transgene insertion 23.2, Tim Sparwasser","Foxp3 (forkhead box P3)",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-08","Cryopreserved sperm"]
[8212,"B6 – HSPA5tm1Dtau","C57BL/6N-Hspa5<tm1(KOMP)Vlcg>/MarpDtau",null,"Recessive","heat shock protein 5","Hspa5","Unknown","78kDa, baffled, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, mBiP, Sez7, XAP-1 antigen","MGI:95835","heat shock protein 5; targeted mutation 1, Velocigene","Hspa5<tm1(KOMP)Vlcg>","MGI:4399453","2",{"$nulls":28},"Lethal","Heterozygous mice expressed 50% level ofwild type HSPA5 expression. However, there was no difference in biochemical induction of the ER stress response in vivo.","C57BL/6N","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-03-07","Cryopreserved sperm"]
[8217,"RCE:LoxP","B6.129P2-Gt(ROSA)26Sor<tm1.1(CAG-EGFP)Fsh>/Anu",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1 ","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Gordon Fishell","Gt(ROSA)26Sor<tm1.1(CAG-EGFP)Fsh>","MGI:4412373","6",{"$nulls":28},"Unknown",null,"C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-15"]
[8222,"ENU35:014:Fam129c","C57BL/6NCrlAnu-Fam129c<m1Anu>/AnuApb",null,"Recessive","family with sequence similarity 129, member C","Fam129c","Unknown","Bcnp1","MGI:3686743",{"$nulls":3},"8","ENSMUSG00000043243","ENSMUST00000143662.7","Fam129c-001","184","305","A to T","ENSMUSE00001283995","2","62","Lysine to STOP",{"$nulls":4},"ACCCAGCCGGATGCCAGCTGTCCCACACCAAAAAGCTGCCTCGAGTCAGGGAGCACCAAGG",{"$nulls":13},"Increased IgM expression on mature B cells in mice homozygous for the mutation, as measured by peripheral blood flow cytometry.","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-21","Cryopreserved sperm"]
[8223,"Enu32:025:Tmem2","C57BL/6NCrlAnu-Tmem2<m1Anu>/AnuApb",null,"Recessive","transmembrane protein 2","Tmem2","Unknown","3110012M15Rik, mKIAA1412","MGI:1890373",{"$nulls":3},"19","ENSMUSG00000024754","ENSMUST00000096194.8","Tmem2-202",{"$nulls":7},"21811978","9",null,null,"TCACCGTGCACGGGACCAGTGGCTTGCTAGTAAGTAGCCTCACCTTGTGTTGACATGCAG",{"$nulls":13},"Embryonic lethal. Embryos die before E14.","Unknown","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-03-21","Cryopreserved sperm"]
[8229,"hAHRKI","B6.129P2-Ahr<tm1(AHR)Mym>/MarpAnu",null,"Recessive","aryl-hydrocarbon receptor","Ahr",null,"Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In","MGI:105043","aryl-hydrocarbon receptor; targeted mutation 1, Masayuki Yamamoto","Ahr<tm1(AHR)Mym>","MGI:3776466","12",{"$nulls":28},"Unknown",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-28","Cryopreserved sperm"]
[8230,"hIL21R:OT1","B6-Il21r<IL21R> Tg(TcraTcrb)1100Mjb/MarpAnu",null,"Recessive","interleukin 21 receptor","Il21r",null,"NILR","MGI:1890475",{"$nulls":3},"7",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","H-2K<b> promoter",{"$nulls":10},"Carry OVA-specific, H-2K<b>-restricted T cell receptor",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-28","Cryopreserved sperm"]
[8234,"Il21r KO_Smarta_Ly5a","B6.Cg-Il21r<tm1Wjl> Ptprc<a> Tg(TcrLCMV)Aox)/MarpAnu",null,"Semi-dominant","interleukin 21 receptor","Il21r","Nil","NILR","MGI:1890475","interleukin 21 receptor; targeted mutation 1, Warren J Leonard","Il21r<tm1Wjl>","MGI:2446509","7",{"$nulls":16},"transgene insertion, Annette Oxenius",null,null,"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","Lack of Il21 receptor expression.Il21r KO mice have:Abnormal immunoglobulin level.Increased IgE level:• serum levels of IgE in nave mice are higher than in controls• ovalbumin immunized mice have variable total IgE levels with some mice having levels similar to wild-type and some mice having 3- to 6- fold higher amounts• total IgE production is increased about 50-fold after KLH immunization with similar increases with antigen specific antibody• IgE levels are 20- to 25- fold greater than controls 100 days after infection with toxoplasma gondiiDecreased IgG1 level:• serum levels of IgG1 in nave mice are lower than in controls• after immunization with ovalbumin, the normal increase in IgG1 seen in wild-type mice is markedly impaired in these mice• in immunized mice, total serum IgG1 is 4 to 5% of wild-type and levels of antigen-specific antibody is 0.1% of that in wild-type• an impaired IgG1 response is also observed after keyhole limpet hemocyanin (KLH) immunization, with antigen specific antibodies being 1/10 of that found in wild-type• IgG1 levels are third of controls 100 days after infection with toxoplasma gondiiDecreased IgG2a level:• IgG2a levels are lower than controls 100 days after infection with toxoplasma gondiiDecreased IgG2b level:• serum levels of IgG2b in nave mice are lower than in controls• after ovalbumin immunization, levels of antigen specific IgGb2 antibody are significantly lower• an impaired IgG2b response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type• IgG2b levels are lower than controls 100 days after infection with toxoplasma gondiiDecreased IgG3 level:• after ovalbumin immunization, levels of antigen specific IgG3 antibody are significantly lower• an impaired IgG3 response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type• IgG3 levels are lower than controls 100 days after infection with toxoplasma gondiiAbnormal CD8-positive, alpha-beta T cell physiology:• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-15 in the same manner as wild-type CD8+ T cells• the percentage of antigen-specific CD8+ T cells found in the spleen is a third lower than controls after vaccination• the percentage of CD8+ T cells making IFN-gamma one week after vaccination is about half that of wild-type controlsDecreased cytotoxic T cell cytolysis:• the cytotoxic activity of CD8+ T cells is significantly lower than wild-type cellsDecreased interleukin-17 secretion:• IL-17 production by CD4 T cells is much lower than controls when activated with IL-6 and TGF-beta in vitro• there is no IL-17 production from T cells when activated in vitro with IL-21 and TGF-beta compared to the robust production of controlsExpresses TCR specific for LCMV GP-derived epitpoe P13",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-28","Cryopreserved sperm"]
[8240,"TgPKR","C57BL/6-Tg(Vav1-EIF2AK2)#Wsmay/JAnu",null,"Dominant",{"$nulls":25},"transgene insertion, W May","mouse vav 1 oncogene",{"$nulls":10},"TgPKR mice express wildtype (catalytically-active) human PKR exclusively in hematopoietic cells/tissues under control of the mouse HS21/45-vav regulatory elements. This PKR overexpression results in significantly defective hematopoiesis, bone marrow failure and increased sensitivity to apoptosis-inducing cell stress. These TgPKR mice may be useful in studying increased PKR activity in diseases such as myelodysplastic syndrome (MDS). ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-31"]
[8247,"Srsf3-flox","B6;129-Srsf3<tm1>/MarpApb",null,"Recessive","serine/arginine-rich splicing factor 3","Srsf3","Unknown","Sfrs3, X16","MGI:98285",{"$nulls":3},"17",{"$nulls":28},"No phenotype","No phenotype","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2017-04-20","Cryopreserved sperm"]
[8248,"Srsf3-flox UBC-cre/ert tetO-OSKM","B6;129-Srsf3<tm1> Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn Tg((UBC-cre/ERT2)1Ejb/MarpApb",null,"Recessive","serine/arginine-rich splicing factor 3","Srsf3","Unknown","Sfrs3, X16","MGI:98285",{"$nulls":3},"17",{"$nulls":16},"transgene insertion 1, Eric J Brow","human ubiquitin C (UBC) promoter",{"$nulls":10},"Unknown","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2017-04-28","Cryopreserved sperm"]
[8244,"Ai32:ePet-cre","B6.Cg-Gt(ROSA)26Sor<tm32(CAG-COP4*H134R/EYFP)Hze> Tg(Fev-cre)1Esd/JAusb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 32, Hongkui Zeng","Gt(ROSA)26Sor<tm32(CAG-COP4*H134R/EYFP)Hze>","MGI:5013789","6",{"$nulls":16},"transgene insertion 1, Evan S Deneris","ETS oncogene family","serotonergic-specific",{"$nulls":9},"No analysis performed",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-04-06"]
[8251,"Warpy mix","B6;C3H-Dzip1l<warpy>/AnuUqApb",null,"Recessive","DAZ interacting protein 1-like","Dzip1l",null,null,"MGI:1919757","DAZ interacting protein 1-like; Warpy","Dzip1l<warpy>","MGI:5563494","9","ENSMUSG00000037784","ENSMUST00000078367","Dzip-1l-001","1123","1326","C to T","ENSMUSE00000325142","8","375","Glutamine to STOP",{"$nulls":4},"TGTCTCAGGACCAGAAGAAAGCAGCTGCCCAGTCTCAGCGCCATATCAATGCCCTCCGTGC","Yes",{"$nulls":12},"Polydactlyly and craniofacial dismorphology in embryos at e14.5.Extra digits on each limb some have 6 some have 7) and there is a craniofacial dismorphology (the front of the head protrudes, the eye position is changed and there is a mandible malformation.","Normal","B6 x C3H","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",null,"1",null,"No","2017-05-08","Cryopreserved sperm"]
[8259,"PbT-II","C57BL/6-Tg(Tcra,TcrbPbA)1Cbn",null,"Dominant",{"$nulls":25},"T cell receptor alpha, T cell receptor beta",{"$nulls":11},"Expression of a TCR specific for the malaria parasite Plasmodium",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-05-24","Cryopreserved sperm"]
[8260,"Ck6/ECFP","B6.129-Tg(CAG-ECFP)CK6Nagy",null,"Dominant",{"$nulls":25},"transgene insertion CK6, Andras Nagy","cytomegalovirus (CMV) immediate early enhancer coupled to the chicken beta actin promoter",{"$nulls":10},"Expression of enhanced cyan fluorescent protein",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-05-24","Cryopreserved sperm"]
[8261,null,"NOD-Ins1<em1(INS)Tkay>/Tkay",null,"Recessive","insulin I","Ins1",null,null,"MGI:96572","INS knockin",null,null,"19",{"$nulls":28},"Normal","Normal","NOD/Lt","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-05-25","Cryopreserved sperm"]
[8264,null,"Adidas #81",null,"Recessive","nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100","Nfkb2","Unknown","NF kappaB2, p52","MGI:1099800",{"$nulls":3},"19",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-06-02"]
[5150,"McBride","C;B6-Myd88<tm1Aki>/AnuApb",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":15},"Yes",{"$nulls":12},"Increased apoptosis:* 5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells.Increased physiological sensitivity to xenobiotics:* knockout mice are more susceptible to bleomycin-induced lung injury.Abnormal dendritic cell differentiation:* dendritic cell maturation fails to occur in vivo upon exposure to TLR9 agonists.Increased dendritic cell number:* increased numbers of dendritic cells in brains of mice infected with Plasmodium.Abnormal immune system physiology:* response to LPS and CpG is completely abrogatedAbnormal dendritic cell physiology:* cytokine secretion elicited by zymosan or LPS is impaired.* following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40, IL-6 and interferon-gamma relative to wild-type mice.Abnormal macrophage physiology:* TNF production is impaired in thioglycollate-elicited macrophages treated with intact zymosan.* cytokine production by macrophages cultured with P. carinii cysts is reduced compared to wild-type.Abnormal NK cell physiology:* NK cells fail to make IFN-gamma in response to injections of TLR9 agonists.Abnormal T cell physiology:* induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonists, was severely impaired.Abnormal cytokine secretion:* LPS-induced cytokine production by BMDCs is almost abolished compared to controls and Myd88-sufficient mutantsAbnormal chemokine secretion:* hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice.Decreased interferon-alpha secretion:* CpG-A or RNA polyuridylic acid induced production of interferon-alpha was abolished in plasmacytoid dendritic cells.Decreased interferon-gamma secretion:* less up regulation of INF-gamma in Plasmodium infection.* following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less interferon-gamma.Decreased interleukin-12 secretion:* after stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.Decreased interleukin-12b secretion:* less upregulation of IL-12b in Plasmodium infection>* following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice.Decreased interleukin-6 secretion:* following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, IL-6 secretion is reduced.* following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-6 relative to wild-type mice.Decreased tumor necrosis factor secretion:* less upregulation of TNF-alpha in Plasmodium infection.* following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.* after stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.Decreased inflammatory response:* in a model of induced pneumococcal meningitis-associated labyrinthitis, homozygotes exhibit a significantly lower granulocytic infiltration of the labyrinth and increased bacterial density in the cochlea at 24 hrs post-infection relative to wild-type control mice.Abnormal response to infection:* following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a decreased immune response in terms of TNF and IL-6 secretion and response to CpG.Decreased susceptibility to parasitic infection:* resistant to cerebral malaria but eventually die of extremely high parasitemia.Increased susceptibility to viral infection:* increased susceptibility to encephalomyocarditis virus (EMCV) infection compared to wildtype.",null,"BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-06-09","Cryopreserved sperm"]
[4466,"B10.PD1","C57BL/10-Tg(PD1)/AnuApb",null,"Dominant",{"$nulls":25},"porcine class I major histocompatibility complex (SLA) gene",{"$nulls":11},"This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.",null,"C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm"]
[4083,null,"ENU7PMH:118, Metabolic_Lean_1",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Low percentage of body fat when fed on a high fat diet.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[4092,null,"KRN:048",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"2",null,"No","2008-12-04","Cryopreserved sperm"]
[4097,null,"KRN:026",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model. Candidate gene position likely to be Chr 1 or 5.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm"]
[4100,null,"KRN:196",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Hypo response post arthritogenic serum transfer",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"1",null,"No","2008-12-04","Cryopreserved sperm"]
[4109,null,"KRN:137",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm"]
[8266,null,"ENU37:009",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Homozygous mice have increased immature B cells in the blood and absence of marginal zone B cells in the spleen.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-06-07","Cryopreserved sperm"]
[8269,"Lifr fl:LysMcre","B6.129P2-Lifr<tm1a(EUCOMM)Hmgu> Lyz2<tm1(cre)Ifo>/JAusbAnu",null,"Recessive","leukemia inhibitory factor receptor","Lifr",null,"A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788","leukemia inhibitory factor receptor; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Lifr<tm1a(EUCOMM)Hmgu>","MGI:4841519","15"]
[8271,"nZegEGFP:Hamlet","C57BL/6JSfdAnu-Tg(IghelMD4)4Ccg Tg(/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"low copy number",{"$nulls":9},"Bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background. Transgenic mice, more than 90% of B-cells in the spleen are derived from the transgene (a allotype) and are predominantly IgM and IgD. There is a moderate reduction in B cell frequency and number in spleen and lymph node. B cells did not express Ly-1 or Mac-1. The Ig phenotype of splenic B cells in adult mice (IgMhiIgDlo-hi) resembled that of splenic B cells in non-transgenic 1 - 2-week-old mice.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"17",null,"No","2017-07-05","Cryopreserved sperm"]
[{"$nulls":30},"chemokine (C-X-C motif) receptor 5","lymphocyte protein tyrosine kinase"]
[8281,"Tg (Tff1-CreERT2; Tff2-rtTA; Tff3-Luc); TRE-Stat3.1348; R26-LSL-YFP; LSL-LacZ13","B6-Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-luc) Gt(ROSA)26Sor<tm1(EYFP)Cos> Gt(ROSA)26Sor Col1a1<tm1(TetO-RNAi:Stat3)>",null,"Recessive","collagen, type I, alpha 1","Col1a1",null,"Col1a-1, Cola1, Cola-1, Mov-13","MGI:88467",{"$nulls":3},"11",{"$nulls":16},"Trefoil","Tff1 driving CreERT2; Tff2 driving rtTA; Tff3 driving luciferase",{"$nulls":12},"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-08-11","Cryopreserved sperm"]
[8290,null,"ENU36:003",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Increased CD44 expression on naive CD4 and CD8 T cells",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-08-22","Cryopreserved sperm"]
[8286,"ASD749:Tacr3","C57BL/6NCrlAnu-Tacr3<en1Anu>/Anu",null,"Recessive","tachykinin receptor 3","Tacr3","Unknown","neuromedin K receptor, Nk3r, Tac3r","MGI:892968",{"$nulls":3},"3",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-08-21","Cryopreserved sperm"]
[8291,"NSG.DQ8.HuPI","NOD.Cg-Prkdc<scid> H2-Ab1<tm1Gru> Il2rg<tm1Wjl> Ins1<em1(INS)Tkay> Tg(HLA-DQA1,HLA-DQB1)1Dv ",null,"Recessive","insulin I","Ins1","Nil",null,"MGI:96572",{"$nulls":3},"19"]
[8284,"Spi6 KO","C57BL/6-Serpinb9<GFP>/Marp",null,"Recessive","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9","Unknown","ovalbumin, PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-16","Cryopreserved sperm"]
[8288,"AMPK a1(S496A) KI","C57BL/6-Prkaa1<em1(S496A)>",null,"Recessive","protein kinase, AMP-activated, alpha 1 catalytic subunit","Prkaa1",null,"AMPKalpha1, C130083N04Rik","MGI:2145955",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-22","Cryopreserved sperm"]
[8285,"Mir155 KO:CMV-cre","B6.Cg-Mir155<tm1.2Anu> Tg(CMV-cre)1Cgn/J",null,"Recessive","microRNA 155","Mir155","Unknown","Mirn155, mmu-mir-155","MGI:2676840",{"$nulls":3},"16",{"$nulls":16},"transgene insertion 1, University of Cologne","CMV",{"$nulls":10},"Unknown",null,"C57BL/6NCrlnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-18","Cryopreserved sperm"]
[8289,"AMPK a1(T481/S487A) KI","C57BL/6-Prkaa1<em2(T481/S487A)>/Ausb",null,"Recessive","protein kinase, AMP-activated, alpha 1 catalytic subunit","Prkaa1","Unknown","AMPKalpha1, C130083N04Rik","MGI:2145955",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-08-22","Cryopreserved sperm"]
[8300,"IRF4:1 bp deletion","C57BL/6NCrlAnu-Irf4<em2Anu>/Anu",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-07","Cryopreserved sperm"]
[8292,null,"ASD820:CBA/CaJAnu:F1",null,"Recessive",{"$nulls":37},"This widely used general purpose strain is the only CBA substrain that carries the Pde6brd1 mutation, which causes blindness by wean age. Renal tubulointerstitial lesions have been observed in this strain at a high frequency. Some CBA/J mice spontaneously develop exocrine pancreatic insufficiency syndrome. Research includes immunology and inflammation, metabolism, hearing and cochlear function, infectious disease, and fetal development. ","Normal Wildtype","CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-23","Cryopreserved sperm"]
[8294,"Sparc KO","B6.129S-Sparc<tm1Hwe>",null,"Recessive","secreted acidic cysteine rich glycoprotein","Sparc","Nil","BM-40, osteonectin","MGI:98373","secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe","Sparc<tm1Hwe>","MGI:1888383","11",{"$nulls":28},"Early onset of cataract formation. Otherwise normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-29","Cryopreserved sperm"]
[8295,"HeparanaseKO","B6.129-Hpse<tm1Jpli>/AnuApb",null,"Recessive","heparanase","Hpse","Nil","Hpa","MGI:1343124","heparanase; targeted mutation 1, Jin-Ping Li","Hpse<tm1Jpli>","MGI:3844469","5",{"$nulls":28},"Heparanase KO mice are fertile with no immunological phenotype observed.","Normal.","C57BL/6JAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-29","Cryopreserved sperm"]
[8298,"ENU34:60:Trmt1","C57BL/6NCrlAnu-Trmt1<m1Anu>/AnuApb",null,"Recessive","tRNA methyltransferase 1","Trmt1","Unknown","6720406L13Rik, D8Ertd812e","MGI:1289155",{"$nulls":3},"8","ENSMUSG00000001909","ENSMUST00000001974.10","Trmt1-201","1001","1532","T to G","ENSMUSE00001239169","8","334","Valine to Glycine",{"$nulls":4},"TGTACGTGTTTTCACAGGCCAGGCCAAGGTTAAGTCCTCAGCCAGCAAACAGGCCCTGGTG",{"$nulls":13},"Homozygous mice show poor response to infection","Normal","C57BL/6NCrlAnu","Unknown","Yes","Yes","Unknown","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-06","Cryopreserved sperm"]
[8299,"IRF4:T95R","C57BL/6NCrlAnu-Irf4<em1Anu>/Anu",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-07","Cryopreserved sperm"]
[8301,"IRF4:49bp deletion","C57BL/6NCrlAnu-Irf4<em3Anu>/Anu",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-07","Cryopreserved sperm"]
[8293,"AMPK a1(S487A) KI","C57BL/6-Prkaa1<em3(S487A)>/Ausb",null,"Recessive","protein kinase, AMP-activated, alpha 1 catalytic subunit","Prkaa1",null,"AMPKalpha1, C130083N04Rik","MGI:2145955",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-08-28","Cryopreserved sperm"]
[8296,"ASD737:Zic2","C57BL/6NCrlAnu-Zic2<em1Anu>/AnuApb",null,"Recessive","zinc finger protein of the cerebellum 2","Zic2","Unknown","GENA 29, Ku, odd-paired homolog","MGI:106679",{"$nulls":3},"14",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-09-05","Cryopreserved sperm"]
[8297,"ASD547:Tle2","C57BL/6NCrlANu-Tle2<em1Anu>/Anu",null,"Recessive","transducin-like enhancer of split 2","Tle2","Unknown","Grg2","MGI:104635",{"$nulls":3},"10",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-05","Cryopreserved sperm"]
[8302,"IGFBP-3-null ","B6J.129S-Igfbp3<tm1Jep>",null,"Recessive","insulin-like growth factor binding protein 3","Igfbp3","Nil","IGFBP-3","MGI:96438","insulin-like growth factor binding protein 3; targeted mutation 1, John E Pintar","Igfbp3<tm1Jep>","MGI:3663361","11",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-12","Cryopreserved sperm"]
[8305,"APPPS1","B6.C3-Tg(APPswe,PSEN1dE9)85Dbo/JAusbAnu","B6.C3-Tg(APPswe,PSEN1dE9)85Dbo/JAusbAnu","Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","mouse prion protein ","Predominantly to CNS neurons",{"$nulls":9},"Unknown","Mice develop beta amyloid deposits in brain by 6 or 7 months of age. The humanized Mo/HuAPP695swe transgene allows the mice to secrete a human A-beta peptide.A slight alteration in the tail can occur due to mixed background.","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1","1","Maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice","No","2017-09-14","Cryopreserved sperm"]
[8304,"Gpx4 fl","B6.129S6-Gpx4<tm1.1Qra>/JAnu",null,"Recessive","glutathione peroxidase 4","Gpx4","Unknown","1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase","MGI:104767","glutathione peroxidase 4; targeted mutation 1.1, Qitao Ran","Gpx4<tm1.1Qra>","MGI:5425616","10",{"$nulls":28},"Normal",null,"C57L/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-14"]
[8303,"ObR fl","B6.129P2-Lepr<tm1Rck>/JAnu",null,"Recessive","leptin receptor","Lepr","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP","MGI:104993","leptin receptor; targeted mutation 1, Jeffrey M Friedman","Lepr<tm1Rck>","MGI:2176774","4",{"$nulls":28},"Normal",null,"C57L/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-14"]
[8306,"AMPK a2(T485A/S491A) KI","C57BL/6-Prkaa2<em1(T485A/S491A)>",null,"Recessive","protein kinase, AMP-activated, alpha 2 catalytic subunit","Prkaa2","Unknown","2310008I11Rik, AMPKalpha2","MGI:1336173",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-09-19","Cryopreserved sperm"]
[8307,"Slp2 KO","B6.129P2-Sytl2<tm1Mitf>/RbrcAnuApb",null,"Recessive","synaptotagmin-like 2","Sytl2","Nil","Slp2, Slp2-a, Slp2-b, Slp2-c, Slp2-d","MGI:1933366","synaptotagmin-like 2; targeted mutation 1, Mitsunori Fukuda","Sytl2<tm1Mitf>","MGI:3693881","7",{"$nulls":28},"Abnormal gastric surface mucous cell morphology:• the number of mucus granules is decreased, 2.8-fold fewer granules are docked with the apical membrane, mucus granule size is increased, and irregular apical membranes are frequently observed• however, no clear abnormalities are seen in the thickness of the epithelia or the numbers of parietal, neck, or chief cellsDecreased digestive secretion:• reduced basal mucin secretion by gastric epithelial cells; however when stimulated with A23187 mucus secretion is similar to wild-type cells",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-20","Cryopreserved sperm"]
[8308,"Helios floxed:Lck-cre","B6.Cg-Ikzf2<tm1.1Etms> Tg(Lck-Cre)/Anu",null,"Recessive","IKAROS family zinc finger 2","Ikzf2",null,"A730095J18Rik, Helios, Zfpn1a2","MGI:1342541","IKAROS family zinc finger 2; targeted mutation 1.1, Ethan M Shevach","Ikzf2<tm1.1Etms>","MGI:4456473","1",{"$nulls":16},"targeted mutation I57, Jamey Marth; transgene insertion I57, Jamey Marth","mouse proximal Lck promoter","active in thymocytes and splenocytes",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-22","Cryopreserved sperm"]
[8309,"CD19-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":28},"Egr2 f/f.Egr3-/-.CD4-cre+ mice develop autoimmune disease at around three months of age or older.  Egr2 f/f.CD4-cre+ mice develop milder autoimmune disease and at a slower rate.  Egr3-/- exhibit some neurological defects.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2017-09-22","Cryopreserved sperm"]
[8309,"CD19-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[8309,"CD19-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","CD19 antigen","Cd19",null,null,"MGI:88319","CD19 antigen; targeted mutation 1, University of Cologne","Cd19<tm1(cre)Cgn>","MGI:1931143","7"]
[7984,"Recql4 K525A","C57BL/6-Recql4<tm4Crw>",null,"Dominant","RecQ protein-like 4","Recql4","Nil",null,"MGI:1931028","Recql4<tm4Crw>","Recql4 K525A",null,"15",{"$nulls":28},"As young mice no phenotype is yet apparent (8-12 week old) homozygous PM. Fertility unknown at this point","Hets appear normal and fertile","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Excellent","generated on pure C57BL/6 so not backcrossed. Only maintained on C57","NA","PM/+ to either PM/+ or WT","No","2015-10-27","Cryopreserved sperm"]
[8310,null,"Kif1bp KO",null,"Recessive","kinesin family member 1 binding protein","Kif1bp","Nil","0710007C18Rik, 2510003E04Rik, mKIAA1279","MGI:1919570","Kif1bp; KBP ",null,null,"10",{"$nulls":28},"Neonatal lethal. Die at birth due to breathing difficulties. Mice display broad peripheral neuropathies, as well as small olfactory bulbs and reduced white mater tracts (anterior commissure). ","\"Normal\"","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-25","Cryopreserved sperm"]
[7985,"Recql4 G522EfsX43","C57BL/6-Recql4<tm5Crw>",null,"Dominant","RecQ protein-like 4","Recql4","Nil",null,"MGI:1931028","Recql4<tm5Crw>","Recql4 G522EfsX43",null,"15",{"$nulls":28},"unknown - we havent recovered any homozygous point mutants at time of submission to APN","Hets appear normal and fertile","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent","generated on pure C57BL/6 so not backcrossed. Only maintained on C57",null,"PM/+ to either PM/+ or WT","No","2015-10-27","Cryopreserved sperm"]
[8313,null,"ASD696:Thunderbird:19del::N1",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-28","Cryopreserved sperm"]
[8319,"SKAM gene trapped","B6.129P2-Fgfr1op2<Gt(CA0175)Wtsi>/MarpApb",null,"Recessive","FGFR1 oncogene partner 2","Fgfr1op2",null,"1500031J01Rik","MGI:1914779","FGFR1 oncogene partner 2; gene trap CA0175, Wellcome Trust Sanger Institute","Fgfr1op2<Gt(CA0175)Wtsi>","MGI:3858415","6",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm"]
[8314,"ENU37:037:Casp4","C57BL/6NCrlAnu-Casp4<m2Anu>/AnuApb",null,"Recessive","caspase 4, apoptosis-related cysteine peptidase","Casp4","Unknown","Casp11, Caspase-11, ich-3","MGI:107700",{"$nulls":3},"9",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-28","Cryopreserved sperm"]
[8315,null,"GLUT12 KO",null,"Recessive","solute carrier family 2 (facilitated glucose transporter), member 12","Slc2a12",null,"Glut12, GLUT-12","MGI:3052471",{"$nulls":3},"10",{"$nulls":28},"Glucose intolerantInsulin intolerantInsulin Resistance","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-02","Cryopreserved sperm"]
[8316,"GLUT12FloxMCKCre","C57BL/6-Slc2a12<tm1> Tg(Ckm-cre)28Arte/Apb",null,"Semi-dominant","solute carrier family 2 (facilitated glucose transporter), member 12","Slc2a12",null,"Glut12, GLUT-12","MGI:3052471",{"$nulls":3},"10",{"$nulls":16},"transgene insertion 28, TaconicArtemis",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-10-02","Cryopreserved sperm"]
[8320,"SK1 KO","B6.129S6-Sphk1<tm1Rlp>/Apb",null,"Recessive","sphingosine kinase 1","Sphk1","Nil","1110006G24Rik, SK1","MGI:1316649","sphingosine kinase 1; targeted mutation 1, Richard L Proia","Sphk1<tm1Rlp>","MGI:3526071","11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm"]
[8311,"Surge","C57BL/6NCrlAnu-Foxb1<em1Anu>/AnuApb",null,"Recessive","forkhead box B1","Foxb1","Unknown","C43, Fkh5, Foxb1a, Foxb1b, Hfh-e5.1, Mf3, TWH","MGI:1927549",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-09-28","Cryopreserved sperm"]
[8326,null,"C57BL/6NCcb",null,"Dominant","N/A",{"$nulls":4},"N/A",null,null,"Unknown",{"$nulls":28},"Wild type","Wild type","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-05","Cryopreserved sperm"]
[8325,"Dsg2floxed-Cdh5-iCreER-T2 ","C57BL/6N-Dsg2<tm1b> Tg(Cdh5-creERT2)1Rha/CcbApb",null,"Recessive","desmoglein 2","Dsg2",null,"D18Ertd293e","MGI:1196466",{"$nulls":3},"18",{"$nulls":16},"transgene insertion 1, Ralf H Adams","VE-cadherin (Cdh5)",{"$nulls":10},"Phenotypically healthy under normal conditions. Unknown state when induced with tamoxifen, but predicted to exhibit depleted Dsg2 in vascular endothelial cells only, suggested to cause vascular complications.","Predicted to be the same, but less pronounced, than the homozygous mice.","C57BL/6N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-05","Cryopreserved sperm"]
[8324,"Dsg2fl/fl","C57BL/6N-Dsg2<tm1c>/CcbApb",null,"Recessive","desmoglein 2","Dsg2",null,"D18Ertd293e","MGI:1196466",{"$nulls":3},"18",{"$nulls":28},"Normal","Normal","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-05","Cryopreserved sperm"]
[8328,"empire ; hSPHK1-Tie2 Tg","C57BL/6-Tg(Tie2-SPHK1)/CcbApb",null,"Dominant",{"$nulls":25},"human Sphingosine Kinase 1 (SPHK1)","Tie-2",{"$nulls":10},"Homozygous mice are viable, fertile, normal in size and to not display any gross physical or behavioural abnormalities. Enhanced SPHK1 expression and activity in the blood vasculature, particularly highly vascularised organs, due to the tie-2 promoter. Some differences seen in blood vessel development and arthritis development compared to wild type. ","Normal ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","4",null,null,"No","2017-10-05","Cryopreserved sperm"]
[8321,"DSG2tma1","C57BL/6N-Dsg2<tm1a(EPD0156_5_E04)>/MarpCcbApb",null,"Recessive","desmoglein 2","Dsg2","Reduced","D18Ertd293e","MGI:1196466","DSG2, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC",null,null,"18",{"$nulls":28},"Homozygous mice are viable, fertile, normal in size and Mendelian ratio. They do not display any gross physical or behavioural abnormalities under homeostatic conditions. Notably, when challenged their significant reduction in Dsg2 gene expression translates into noticeable differences in blood vessel development, morphology and function, diabetes susceptibility and cancer progression. A pathology of cardiac fibrosis, which mimics the human condition, has been observed after humane killing but no observable effects related to this have been observed prior. Gene and protein expression experiments confirm that a low level of DSG2 is maintained in these mice; hence Dsg2 lo/lo.","Normal","C57BL/6N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-05","Cryopreserved sperm"]
[8329,"ASD613:Pyro:8","C57BL/6NCrlAnu-Ptpn22<em1Anu>/AnuApb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 22 (lymphoid)","Ptpn22","Unknown","70zpep, Ptpn8","MGI:107170",{"$nulls":3},"3",{"$nulls":28},"Unknown",null,"C57BL/6CrlAnu","Yes","Unknown","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-10","Cryopreserved sperm"]
[8330,"Chat-cre","B6;129S6-Chat<tm2(cre)Lowl>/JAnu",null,"Dominant","choline acetyltransferase","Chat",null,"B230380D24Rik","MGI:88392","choline acetyltransferase; targeted mutation 2, Bradford B Lowell","Chat<tm2(cre)Lowl>","MGI:5475195","14",{"$nulls":28},"Normal",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-11","Cryopreserved sperm"]
[8334,"R26 WT-Hoxa1 ki","B6JArc.Cg-Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"Semi-dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 3237, TaconicArtemis","Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"6",{"$nulls":28},"Unknown","Unknown","C57BL/6JArc","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Excellent","10",null,null,"No","2017-10-23","Cryopreserved sperm"]
[8336,"ptpn14flox/flox","B6(Cg)-Ptpn14<tm1c(EUCOMM)Hmgu>/MarpCcb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 14","Ptpn14",null,"C130080N23Rik, OTTMUSG00000022087, PTP36","MGI:102467",{"$nulls":3},"1",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-27","Cryopreserved sperm"]
[8332,"RBC16","B6.C-Cpox<m1Wehi>/WehiMarp",null,"Dominant","coproporphyrinogen oxidase","Cpox","Unknown","cac, clone 560, Cpo, nct","MGI:104841","W373*",null,null,"16",{"$nulls":28},"Lethal (approx. e9.5)","Microcytosis","C57BL/6;BALB/c","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-16"]
[1781,"Cathepsin L Knockout","C57BL/6-Cstl<tm1Cptr>/WehiAnuApb",null,"Recessive","cathepsin L","Ctsl","Unknown","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03","Cryopreserved sperm"]
[8337,"ptpn14flox/flox/CMVCre","B6(Cg)-Ptpn14<tm1d(EUCOMM)Hmgu>/MarpCcb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 14","Ptpn14","Unknown","C130080N23Rik, OTTMUSG00000022087, PTP36","MGI:102467",null,"Ptpn14<tm1d(EUCOMM)Hmg>",null,"1",{"$nulls":28},"Periorbital oedema, lower limb oedema","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-27","Cryopreserved sperm"]
[8339,"Egr2f/f","B6.129-Egr2<tm3Pch>/AnuApb",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2017-10-27","Cryopreserved sperm"]
[8339,"Egr2f/f","B6.129-Egr2<tm3Pch>/AnuApb",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[8331,"ASD756:RC3H1:1bpins:4:N3","C57BL/6NCrlAnu-Rc3h1<em1Anu>4/AnuApb",null,"Recessive","RING CCCH (C3H) domains 1","Rc3h1","Unknown","5730557L09Rik, roquin","MGI:2685397",{"$nulls":3},"1",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-12","Cryopreserved sperm"]
[8333,"ASD670:Nacho:::F2","C57BL/6NCrlAnu-Amigo3<em1Anu>/AnuApb",null,"Recessive","adhesion molecule with Ig like domain 3","Amigo3","Unknown","E430002N15Rik","MGI:2444854",{"$nulls":3},"9",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-19","Cryopreserved sperm"]
[8338,"Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi>/AnuApb",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2017-10-27","Cryopreserved sperm"]
[8338,"Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi>/AnuApb",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[8341,"SKAM1A Trangsgenic","C57BL/6-Tg(CAG-FGFR1OP2)/TasqCcb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":16},"human Fibroblast Growth Factor Receptor1 Oncongne partner 2","Chicken Beta actin","All cells",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-31","Cryopreserved sperm"]
[8344,"ASD872","B6.SJL-Ptprc<a>/CrlAnu:Line A",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":30},"C57BL/6NCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-11-03"]
[8335,"ptpn14LacZ/+","B6(Cg)-Ptpn14<tm1a(EUCOMM)Hmgu>/MarpCcb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 14","Ptpn14","Unknown","C130080N23Rik, OTTMUSG00000022087, PTP36","MGI:102467","protein tyrosine phosphatase, non-receptor type 14; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Ptpn14<tm1a(EUCOMM)Hmgu>","MGI:5318763","1",{"$nulls":28},"Periorbital oedema, lower limb oedema.","Normal","C57/BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-27","Cryopreserved sperm"]
[8340,"Spi6 fl; SerpinB9 conditional","C57BL/6J-SerpinB9<tm2.1Pib>/PibMarpAnuApb",null,"Dominant","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9",null,"ovalbumin, PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-10-30","Cryopreserved sperm"]
[8343,"ASD867","BALB/cNCrlAnu:Pink",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-11-03"]
[8342,"ASD866","C57BL/6NCrlAnu:Green",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-11-03"]
[8345,null,"ASD873.Pear",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Unknown",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-07","Cryopreserved sperm"]
[8346,"AMPK b1 KO","C57BL/6-Prkab1<tm1Eihl>",null,"Recessive","protein kinase, AMP-activated, beta 1 non-catalytic subunit","Prkab1","Nil","1300015D22Rik","MGI:1336167","protein kinase, AMP-activated, beta 1 non-catalytic subunit; targeted mutation 1, Bruce E Kemp","Prkab1<tm1Eihl>","MGI:4439277","5",{"$nulls":28},"Homeostasis/metabolism phenotype:N• when fed a high-fat diet, mice exhibit resistance to diet induced hyperinsulinemia and insulin resistance.• mice exhibit normal response to renal ischemia-reperfusion injury.Decreased susceptibility to diet-induced obesity:• when fed a high-fat dietDecreased circulating insulin level:• in fasted mice fed a high-fat dietDecreased circulating leptin level:• whether fed chow or a high-fat dietDecreased circulating interleukin-6 level:• whether fed chow or a high-fat dietIncreased insulin sensitivity:• whether fed chow or a high-fat diet, mice exhibit increased insulin sensitivity compared with similarly treated wild-type mice• when fed a high-fat diet, mice exhibit increased glucose infusion rate suggesting improved skeletal muscle insulin sensitivity compared with similarly treated wild-type mice• whether fed chow or a high-fat diet, mice exhibit reduced hepatic glucose output and greater insulin-induced suppression of hepatic glucose production indicating increased hepatic insulin sensitivity compared with similarly treated wild-type miceAbnormal lipid level:• when fed a high-fat diet, mice exhibit decreased hepatic levels of triglyceride, diglyceride, and ceramide compared with wild-type miceDecreased liver triglyceride level:• when fed a high-fat dietDecreased susceptibility to hepatic steatosis:• when fed a high-fat diet, mice exhibit decreased hepatic levels of triglyceride, diglyceride, and ceramide compared with wild-type miceAbnormal hepatocyte physiology:• hepatocytes exhibit increased fatty acid synthesis and reduced fatty acid oxidation compared with wild-type cells• however, insulin sensitivity of hepatocytes is normal.Decreased epididymal fat pad weight:• whether fed chow or a high-fat diet","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-11-13","Cryopreserved sperm"]
[8347,"AMPK Beta 2 KO","C57BL/6-Prkab2<tm1Grst>",null,"Recessive","protein kinase, AMP-activated, beta 2 non-catalytic subunit","Prkab2",null,"5730553K21Rik","MGI:1336185","protein kinase, AMP-activated, beta 2 non-catalytic subunit; targeted mutation 1, Gregory R Steinberg","Prkab2<tm1Grst>","MGI:5293372","3",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-11-13","Cryopreserved sperm"]
[8350,"ASD726:Taco:3::N1F1","C57BL/6NCrlAnu-Tax1bp1<em2Anu>/AnuApb",null,"Recessive","Tax1 (human T cell leukemia virus type I) binding protein 1","Tax1bp1","Unknown","1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151","MGI:1289308","TAX1BP1-L307l",null,null,"6",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-14","Cryopreserved sperm"]
[8351,"Scn2a R851X","C57BL/6-Scn2a<em1(R851X)>/SpetApb",null,"Dominant","sodium channel, voltage-gated, type II, alpha","Scn2a","Unknown","A230052E19Rik, Nav1.2, Scn2a1","MGI:98248",{"$nulls":3},"2",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2017-11-14"]
[8348,"A1(T183A) KI","C57BL/6-Prkaa1<em4(T183A)>",null,"Recessive","protein kinase, AMP-activated, alpha 1 catalytic subunit","Prkaa1","Unknown","AMPKalpha1, C130083N04Rik","MGI:2145955",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2017-11-14","Cryopreserved sperm"]
[8349,"ASD726:Taco:2::N2F1","C57BL/6NCrlAnu-Tax1bp1<em3Anu>/AnuApb",null,"Recessive","Tax1 (human T cell leukemia virus type I) binding protein 1","Tax1bp1","Unknown","1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151","MGI:1289308",{"$nulls":3},"6",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-14"]
[8352,"GABRG2 R43Q","DBA-Gabrg2<em1>",null,"Semi-dominant","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2  ","Gabrg2",null,"GABAA-R, Gabrg-2, gamma2","MGI:95623",{"$nulls":3},"11",{"$nulls":28},"Partial perinatal lethality:• mice are rarely bornComplete postnatal lethality:• mice that are born die before P19Tremors:• mice that are born exhibit a severe tremorAbnormal gait:• mice that are born have altered gaitsAbnormal brain wave pattern:• mice lack normal brain rhythms","Mice heterozygous for the mutation demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man. Seizures in the mouse showed an abrupt onset at around age 20 days corresponding to the childhood nature of this disease. Reduced cell surface expression of gamma2(R43Q) was seen in heterozygous mice in the absence of any change in alpha1 subunit surface expression","DBA","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-11-23","Cryopreserved sperm"]
[8356,"ASD666:Ramos:9","C57BL/6NCrlAnu-Tlr7<em1Anu>/AnuApb",null,"X-linked","toll-like receptor 7","Tlr7","Unknown",null,"MGI:2176882",{"$nulls":3},"X",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm"]
[8357,"ASD740:Cd79b:Y195H","C57BL/6NCrlAnu-Cd79b<em6Anu>/AnuApb",null,"Recessive","CD79B antigen","Cd79b","Unknown","B29, Igb, Igbeta, Ig-beta","MGI:96431",{"$nulls":3},"11",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm"]
[8358,"ASD869:Sumo","C57BL/6NCrlANU-Irak2<em1ANU>/AnuApb",null,"Recessive","interleukin-1 receptor-associated kinase 2","Irak2",null,"6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d","MGI:2429603",{"$nulls":3},"6",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-29","Cryopreserved sperm"]
[8359,"ASD866","C57BL/6NCrlAnu:Pink",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8361,"ASD866","C57BL/6NCrlAnu:Yellow",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8360,"ASD866","C57BL/6NCrlAnu:Orange",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8363,"ASD867","BALB/cNCrlAnu:Yellow",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8353,"TetTXNIP/Ve-cdh5-rtTA","C57BL/6-Tg(TetO-TXNIP) Tg(Cdh5-tTA)D5Lbjn/Apb",null,"Recessive",{"$nulls":25},"Human thioredoxin interacting protein",{"$nulls":11},"Human TXNIP expressed in endothelial cells after treatment with tetracycline.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm"]
[{"$nulls":30},"Human thioredoxin interacting protein"]
[8354,"TXNIPf-VECcre","C57BL/6-Txnip<fl> Tg(Cdh5-cre)/Apb",null,"Recessive","thioredoxin interacting protein","Txnip","Unknown","Hyplip1, mVDUP1, THIF, VDUP1","MGI:1889549",{"$nulls":3},"3",{"$nulls":16},"Cre recombinase","cadherin 5","Restricted to endothelial cells",{"$nulls":9},"Unknown","Unknown","C57BL6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm"]
[8362,"ASD867","BALB/cNCrlAnu:Orange",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8364,"ASD867","BALB/cNCrlAnu:Green",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8365,"ASD872","B6.SJL-Ptprc<a>/CrlAnu:Line B",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":30},"C57BL/6NCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04"]
[8368,"Aire:Cbl-b:Rag1 KO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> Rag1<tm1Mom>/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb",null,"Cbl-b","MGI:2146430","Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":30},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sib x sib","No","2017-12-08","Cryopreserved sperm"]
[8368,"Aire:Cbl-b:Rag1 KO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> Rag1<tm1Mom>/AnuApb",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2"]
[8368,"Aire:Cbl-b:Rag1 KO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> Rag1<tm1Mom>/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Pltn>","MGI:2182940","10"]
[8367,"Cblb KO","B6(Cg)-Cblb<tm1Pngr>/AnuApb","B6(Cg)-Cblb<tm1Pngr>/AnuApb","Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","Cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit elevated IL2 production by T cells, develop spontaneous autoimmunity, and are highly susceptible to experimental autoimmune encephalomyelitis.",null,"C57BL/NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2",null,null,"No","2017-12-08","Cryopreserved sperm"]
[8366,"ASD726:Taco2:11bp del","C57BL/6NCrlANu-Tax1bp1<em1Anu>/AnuApb",null,"Recessive","Tax1 (human T cell leukemia virus type I) binding protein 1","Tax1bp1","Unknown","1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151","MGI:1289308",{"$nulls":3},"6",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-08","Cryopreserved sperm"]
[8374,"NOD.Nkrp1b.CD3z","NOD-Cd247<C57BL/6> Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"CD247 antigen","Cd247",null,"4930549J05Rik, CD3-eta, Cd3h, Cd3z, CD3zeta, CD3 zeta, CD3-zeta, CD3-zeta/eta, T3z, TCRk, Tcrz","MGI:88334",{"$nulls":3},"1","Mice that are homozygous for this allele are viable, fertile and normal in size. Can be difficult breeders.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for CD3z region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8374,"NOD.Nkrp1b.CD3z","NOD-Cd247<C57BL/6> Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size. Can be difficult breeders.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for CD3z region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8374,"NOD.Nkrp1b.CD3z","NOD-Cd247<C57BL/6> Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 1","Nktcn1",null,"Nkt1","MGI:2681136","natural killer T cell numbers 1; C57BL/6J","Nktcn1<C57BL/6J>","MGI:2681149","1","Mice that are homozygous for this allele are viable, fertile and normal in size. Can be difficult breeders.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for CD3z region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8372,"NOD.H2b.SCID-/-","NOD.Cg-H2<b> Prkdc<scid>/BaxApb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","SCID mutation prevents TCR and BCR rearrangements. This prevents maturation of B and T cells at very early stages of development. These mice, therefore lack, T and B cells in periphery. Please refer to MGI allele page for further information using the link above.Mice that are homozygous for the SCID mutation are viable, fertile, normal in size. This strain is immunocomprimised. Mice homozygous for the severe combined immune deficiency spontaneous mutation (Prkdcscid, commonly referred to as scid) are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Normal antigen-presenting cell, myeloid, and NK cell functions are strain dependent. scid mice carry a DNA repair defect and a defect in the rearrangement of genes that code for antigen-specific receptors on lymphocytes. Most homozygotes have no detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Thymus, lymph nodes, and splenic follicles are virtually devoid of lymphocytes. scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. Some scid mice will spontaneously develop partial immune reactivity. scid mice that have serum Ig levels greater than 1 ug/ml are considered \"leaky.\" scid leakiness is highly strain dependent, increases with age, and is higher in mice housed under non-SPF conditions. In general, scid leakiness is high on the C57BL/6J and BALB/cBy genetic backgrounds, low on the C3H/HeJ background, and even lower on the NOD/ShiLtSz background. NOD/ShiLtSz-Prkdcscid mice are both insulitis- and diabetes-free throughout life and serve as a diabetes-free control for comparison to NOD/ShiLtJ mice. Thymic lymphomas occur with high frequency, however, and life span typically is limited to only 8.5 months under specific pathogen-free conditions.Also contains congenic markers MHC haplotype H2ᵇThe NOD.H2ᵇstrain does not develop insulitis, cyclophosphamide-induced diabetes, or spontaneous diabetes, but does develop extensive lymphocytic infiltrates in the pancreas and the submandibular glands.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"19",null,"No","2017-12-11","Cryopreserved sperm"]
[8373,"NOD.Nkrp1b.Nkt1","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8373,"NOD.Nkrp1b.Nkt1","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 1","Nktcn1",null,"Nkt1","MGI:2681136","natural killer T cell numbers 1; C57BL/6J","Nktcn1<C57BL/6J>","MGI:2681149","1","Mice that are homozygous for this allele are viable, fertile, normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8376,"NOD.Nkrp1b.Slam1c","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6> Slam1c<C57BL/6>/Bax",null,"Recessive",{"$nulls":37},"Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1c region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8380,"NOD.Nkrp1b.Nkt2e","NOD-Klrb1b<C57BL/6> Nktcn2e<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.","Differences in susceptibility to autoimmunity.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-11"]
[8380,"NOD.Nkrp1b.Nkt2e","NOD-Klrb1b<C57BL/6> Nktcn2e<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 2","Nktcn2",null,"Nkt2","MGI:2681137","natural killer T cell numbers 2; C57BL/6J","Nktcn2<C57BL/6J>","MGI:2681151","2","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.","Differences in susceptibility to autoimmunity.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-11"]
[8381,"TCR7","C57BL/6-Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog",null,"Dominant",{"$nulls":25},"transgene insertion 7 Anne O'Garra",{"$nulls":11},"T cells express anti-hen egg lysozyme (HEL) TCR  Valpha11 and Vbeta3 chains",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-12","Cryopreserved sperm"]
[8382,"Ighg1-cre Igk KO","B6.129P2(Cg)-Ighg1<tm1(cre)Cgn> Igk<tm1Dhu>/UbAnu",null,"Recessive","immunoglobulin kappa chain complex","Igk","Nil","kappa","MGI:96494","immunoglobulin kappa chain complex; targeted mutation 1, Dennis Huszar","Igk<tm1Dhu>","MGI:2429510","6",{"$nulls":28},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-12","Cryopreserved sperm"]
[8382,"Ighg1-cre Igk KO","B6.129P2(Cg)-Ighg1<tm1(cre)Cgn> Igk<tm1Dhu>/UbAnu",null,"Recessive","immunoglobulin heavy constant gamma 1 (G1m marker)","Ighg1",null,"IgG1, Igh-4","MGI:96446","immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne","Ighg1<tm1(cre)Cgn>","MGI:3652526","12"]
[8386,"Prox1enhCRISPR-Timon","C57BL/6-Prox1<em6Nlh>",null,"Recessive","prospero homeobox 1","Prox1",null,"A230003G05Rik","MGI:97772",{"$nulls":3},"1",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-18","Cryopreserved sperm"]
[8388,"Prox1enhCRISPR-Pumbaa","C57BL/6-Proz1<em7Nlh>",null,"Recessive","prospero homeobox 1","Prox1",null,"A230003G05Rik","MGI:97772",{"$nulls":3},"1",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-18","Cryopreserved sperm"]
[8385,"Prox1enhCRISPR-Banzai","C57BL/6-Prox1<em5Nlh>",null,"Recessive","prospero homeobox 1","Prox1",null,"A230003G05Rik","MGI:97772",{"$nulls":3},"1",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-18","Cryopreserved sperm"]
[8383,"Integrin beta3 Knockout","C.129S2-Itgb3<tm1Hyn>",null,"Recessive","integrin beta 3","Itgb3","Nil","CD61, platelet glycoprotein IIIa (GP3A)","MGI:96612","integrin beta 3; targeted mutation 1, Richard Hynes","Itgb3<tm1Hyn>","MGI:2175913","11",{"$nulls":28},"Mice look normal, are fertile and breed normally. They have a mild bone phenotype due to dysfunctional osteoclasts. Mice a prone to excesasive bleeding after injury due to defective platelets lacking alphaIIbBeta3 integrin. Females may have placental defects that can lead to fetal mortality.  For this reason, only heterozygote females are used for breeding.","Normal, as WT mice","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-13","Cryopreserved sperm"]
[8371,"NOD.H2b.Nkrp1b","NOD-H2<b> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","Mice that are homozygous for this allele are viable, fertile, normal in size.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8371,"NOD.H2b.Nkrp1b","NOD-H2<b> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8379,"NOD.Nkrp1b.Nkt2a","NOD-Klrb1b<C57BL/6> Nktcn2a<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.","Differences in susceptibility to autoimmunity.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-11","Cryopreserved sperm"]
[8379,"NOD.Nkrp1b.Nkt2a","NOD-Klrb1b<C57BL/6> Nktcn2a<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 2","Nktcn2",null,"Nkt2a","MGI:2681137","natural killer T cell numbers 2; C57BL/6J","Nktcn2<C57BL/6J>","MGI:2681151","2","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.","Differences in susceptibility to autoimmunity.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-11","Cryopreserved sperm"]
[8392,"NOD.Idd13","NOD-Idd13<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 13","Idd13",null,null,"MGI:99415","insulin dependent diabetes susceptibility 13; C57BL/6","Idd13<C57BL/6>","MGI:3044074","2","Mice that are homozygous for this allele are viable, fertile, normal in size.Difference in autoimmunity susceptibility compared to NOD.This strain is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8377,"NOD.Nkrp1b.Slam1D","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6> Slam1D<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8377,"NOD.Nkrp1b.Slam1D","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6> Slam1D<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 1","Nktcn1",null,"Nkt1","MGI:2681136","natural killer T cell numbers 1; C57BL/6J","Nktcn1<C57BL/6J>","MGI:2681149","1","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8377,"NOD.Nkrp1b.Slam1D","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6> Slam1D<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"signaling lymphocytic activation molecule family member 1","Slam",{"$nulls":6},"1","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm"]
[8389,"Conditional SMAD1 f/f","C.129-Smad1<tm2Rob>",null,"Recessive","SMAD family member 1","Smad1",null,"Madh1, Madr1, Smad 1","MGI:109452","SMAD family member 1; targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":28},"Normal","Normal","BALB/c     ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","10",null,null,"No","2017-12-18","Cryopreserved sperm"]
[8390,"Fat4 flox","B6.129-Fat4<tm1.1Hmc>",null,"Recessive","FAT atypical cadherin 4","Fat4",null,"6030410K14Rik","MGI:3045256","FAT atypical cadherin 4; targeted mutation 1.1, Helen McNeill","Fat4<tm1.1Hmc>","MGI:3846573","3",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-18","Cryopreserved sperm"]
[8391,"Gata2 flox","B6.129-Gata2<tm1Msal>",null,"Recessive","GATA binding protein 2","Gata2",null,"Gata-2","MGI:95662","GATA binding protein 2; targeted mutation 1, Marjo Salminen","Gata2<tm1Msal>","MGI:4818492","6",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8395,"NOD.Nkrplb.Slam1D.CD-1","NOD-CD1<tm1Gru> Klrb1b<C57BL/6> Slamf1D<C57BL/6>/Bax",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.\"Mice can have trouble breeding. Keep a close eye on progress and increase breeders as required to maintain line. If a case of breeding ceasing, may need to cross back onto a parental line. Ideally NOD.Nkrplb.Nktl.SlamlD to reduce genotyping.Nkrplb:Congenic Nk Cell Marker. Nktl:Congenic Marker for NKT1 region. Increased Nkt cell numbers.CD-1:Knockout lacking the CD1 antigen complex gene.  Lack an NK-like cell subset.SlamlD:Congenic Marker for Slam1D region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8395,"NOD.Nkrplb.Slam1D.CD-1","NOD-CD1<tm1Gru> Klrb1b<C57BL/6> Slamf1D<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"signaling lymphocytic activation molecule family member 1","Slamf1",null,"CD150, CDw150, ESTM51, IPO-3, Slam","MGI:1351314",{"$nulls":3},"1","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.\"Mice can have trouble breeding. Keep a close eye on progress and increase breeders as required to maintain line. If a case of breeding ceasing, may need to cross back onto a parental line. Ideally NOD.Nkrplb.Nktl.SlamlD to reduce genotyping.Nkrplb:Congenic Nk Cell Marker. Nktl:Congenic Marker for NKT1 region. Increased Nkt cell numbers.CD-1:Knockout lacking the CD1 antigen complex gene.  Lack an NK-like cell subset.SlamlD:Congenic Marker for Slam1D region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8393,"NOD.Idd13.H2b.Nkrp1b","NOD-H2<b> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","Mice that are homozygous for this allele are viable, fertile, normal in size.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8393,"NOD.Idd13.H2b.Nkrp1b","NOD-H2<b> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8393,"NOD.Idd13.H2b.Nkrp1b","NOD-H2<b> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 13","Idd13",null,null,"MGI:99415","insulin dependent diabetes susceptibility 13; C57BL/6","Idd13<C57BL/6>","MGI:3044074","2","Mice that are homozygous for this allele are viable, fertile, normal in size.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8394,"NOD.Idd13.Nkrp1b.Cd-1-/-","NOD-CD1<tm1Gru> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8394,"NOD.Idd13.Nkrp1b.Cd-1-/-","NOD-CD1<tm1Gru> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 13","Idd13",null,null,"MGI:99415","insulin dependent diabetes susceptibility 13; C57BL/6","Idd13<C57BL/6>","MGI:3044074","2","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8396,"NOD.Nkrp1b.Nkt2b.CD-1","NOD-Cd1<tm1Gru> Klrb1b<C57BL/6> Nktcn2b<C57BL/6>/Bax",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Difficult breeders. Have had to restart the breeding, multiple times due to the difficulty in getting them homozygous. Seems homozygous mice do not breed. Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.Knockout lacking the CD1 antigen complex gene",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8396,"NOD.Nkrp1b.Nkt2b.CD-1","NOD-Cd1<tm1Gru> Klrb1b<C57BL/6> Nktcn2b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 2","Nktcn2",null,"Nkt2b","MGI:2681137",{"$nulls":3},"2","Difficult breeders. Have had to restart the breeding, multiple times due to the difficulty in getting them homozygous. Seems homozygous mice do not breed. Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.Knockout lacking the CD1 antigen complex gene",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm"]
[8397,"NOD.Faslm1","NOD-Fasl<m1>/Bax",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Unknown","APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6","MGI:99255",null,"Fasl<m1>",null,"1",{"$nulls":28},"Mice that are homozygous for these alleles are viable, fertile, normal in size. Mice have affected severity of autoimmunity compared to controls.Spontaneous Mutation of Ligand",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8398,"NOD.Faslm2","NOD-Fasl<m2>/Bax",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Unknown","APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6","MGI:99255",null,"Fasl<m2>",null,"1",{"$nulls":28},"Mice that are homozygous for these alleles are viable, fertile, normal in size. Affects severity of autoimmunity compared to controlsSpontaneous Mutation of LigandFaslm2bSpontaneous Mutation of Ligand from C57Bl6 Identical to NOD.Faslm2",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8399,"NOD.Faslm2b","NOD-Fasl<m2b>/Bax",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Unknown","APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6","MGI:99255",null,"Fasl<m2b>",null,"1",{"$nulls":28},"Mice that are homozygous for these alleles are viable, fertile, normal in size. Affects severity of autoimmunity compared to controlsSpontaneous Mutation of LigandFaslm2bSpontaneous Mutation of Ligand from C57Bl6 Identical to NOD.Faslm2",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8400,"NOD.Trail","NOD.129-Tnfsf10<tm1Mjs>/MjsBax",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 10","Tnfsf10","Nil","A330042I21Rik, APO-2L, Trail","MGI:107414","tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Mark J Smyth","Tnfsf10<tm1Mjs>","MGI:2179709","3",{"$nulls":28}," Thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8401,"BALB.4220-3855","BALB/c-Gasa<C57BL/6(4220-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8403,"BALB.8755-3855","BALB/c-Gasa<C57BL/6(8755-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8404,"BALB.931-189B","BALB/c-Gasa<C57BL/6(931-189B)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8402,"BALB.5702-3855","BALB/c-Gasa<C57BL/6(5702-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8405,"BALB.931-203.344-3855","BALB/c-Gasa<C57BL/6(931-203.344-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8406,"BALB.931-203.64-3855","BALB/c-Gasa<C57BL/6(931-203.64-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8409,"NOD.Idd5r","NOD-Idd5r<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 5r","Idd5r",{"$nulls":6},"2","Mice that are homozygous for this allele are viable, fertile, normal in size.This strain is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd5r",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8411,"NOD.H2k.Nkrp1b","NOD-H2<k> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2k:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2k. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19"]
[8411,"NOD.H2k.Nkrp1b","NOD-H2<k> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2k:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2k. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19"]
[8415,"Mdm2<WT>  S6<WT>","B6(Cg).129(Cg)-WT/JAnu",null,"Recessive",{"$nulls":37},"Normal",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-15","Cryopreserved sperm"]
[8410,"NOD.H2d.Nkrp1b","NOD-H2<d> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; d variant","H2<d>","MGI:3579320","17","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2d:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2d. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8410,"NOD.H2d.Nkrp1b","NOD-H2<d> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2d:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2d. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm"]
[8413,null,"ASD827:Fry",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-21","Cryopreserved sperm"]
[8414,"Cd25 KO;OT-I","B6.Cg-Il2ra<tm1Dw> Tg(TcraTcrb)1100Mjb/WehiAnu",null,"Recessive","interleukin 2 receptor, alpha chain","Il2ra",null,"CD25, Il2r, IL-2R alpha chain, Ly-43","MGI:96549","interleukin 2 receptor, alpha chain; targeted mutation 1, Dennis M Willerford","Il2ra<tm1Dw>","MGI:1857192","2",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","MGI:3054907",{"$nulls":10},"Mice homozygous for the CD25 (IL2Ra) targeted mutation are characterized by a lymphoproliferative disorder, hemolytic anemia and an inflammatory bowel disease beginning at approximately 9 weeks of age. Homozygous females may not be healthy enough to breed. ",null,"C57BL/6J","Yes","Unknown","No","Yes","Unknown","No","No","Unknown",{"$nulls":3},"No","2018-01-10","Cryopreserved sperm"]
[8416,"Pad4 fl","B6.Cg-Padi4<tm1.2Kmow>/KmowAnu",null,"Recessive","peptidyl arginine deiminase, type IV","Padi4","Nil","Pad4, PAD type IV, Pdi4","MGI:1338898","peptidyl arginine deiminase, type IV; targeted mutation 1.2, Kerri A Mowen","Padi4<tm1.2Kmow>","MGI:5695766","4",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-16","Cryopreserved sperm"]
[8417,"Egr2-GFP","B6.Cg-Egr2<GFP>/Anu",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296",{"$nulls":3},"10",{"$nulls":31},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-16","Cryopreserved sperm"]
[8412,"ELF5-rRTA-TetO-Cre-Neu","FVB/N.Cg-Tg(Elf5-rtTA,tetO-cre)",null,"Dominant",{"$nulls":25},"ELF5-rRTA, TetO-Cre, Neu","ELF5, TetO, MMTV",{"$nulls":10},"Normal","Normal","FVB/N X BL6/129","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-20","Cryopreserved sperm"]
[8418,"ENU39:064:Casp1:G3","C57BL/6NCrlAnu-Casp1<m1Anu>/AnuApb",null,"Recessive","caspase 1","Casp1","Unknown","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-17","Cryopreserved sperm"]
[8407,"NOD.H2d","NOD-H2<d>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; d variant","H2<d>","MGI:3579320","17","Mice that are homozygous for this allele are viable, fertile, normal in size.Congenic markers MHC haplotype H2<d>",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8408,"NOD.Idd27","NOD-Idd27<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 27","Idd27",null,null,"MGI:3608893",{"$nulls":3},"7","Mice that are homozygous for this allele are viable, fertile, normal in size.This strain is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd27",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm"]
[8419,"Tcf7 fl","B6(Cg)-Tcf7<tm1c(EUCOMM)Wtsi>/WehiAnuApb",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1c, Wellcome Trust Sanger Institute","Tcf7<tm1c(EUCOMM)Wtsi>","MGI:5816259","11",{"$nulls":28},"Normal",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-17","Cryopreserved sperm"]
[8421,"ENU31:016::MD4 ML5:G3","B6.Cg-ENU mutant Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg/Anu",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":16},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":9},"Usually double Tg mice delete many of their self reactive B cells and downregulate expression of both IgM and IgD on the cell surface of the remaining B cells. The phenotype in these interesting mice is a variable lack of deletion and IgM/IgD downregulation",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2018-01-17"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow",null,"High"]
[8426,"RBC19","SJL-Tpi<RBC19>",null,"Semi-dominant","triosephosphate isomerase 1","Tpi1","Unknown","Tpi-1","MGI:98797","Tpi^F57S/F57S",null,null,"6",{"$nulls":28},"Macrocytosis and haemolytic anaemia, high MCV, low RBC, splenomegaly, viable and fertile.","Macrocytosis, high MCV.","SJL","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-25","Cryopreserved sperm"]
[8420,"Lef1 fl","B6.129-Lef1<tm1Hhx>/HhxAnu",null,"Recessive","lymphoid enhancer binding factor 1","Lef1",null,"Lef-1, lymphoid enhancer factor 1","MGI:96770","lymphoid enhancer binding factor 1; targeted mutation 1, Hai-Hui Xue","Lef1<tm1Hhx>","MGI:5447957","3",{"$nulls":28},"Normal",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-17","Cryopreserved sperm"]
[8422,"uPAR KO","B6.129-Plaur<tm1Jld>",null,"Recessive","plasminogen activator, urokinase receptor","Plaur",null,"Cd87, uPAR, u-PAR, urokinase-type plasminogen activator receptor","MGI:97612","plasminogen activator, urokinase receptor; targeted mutation 1, Jay L Degen","Plaur<tm1Jld>","MGI:1857290","7",{"$nulls":28},"Liver inflammationTrachea inflammation","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"brother x sister","Yes","2018-01-18","Cryopreserved sperm"]
[8423,"Kif1bp KO #2","C57BL/6-Kif1bp<em1Hmy>/Hmy",null,"Recessive","KIF1 binding protein","Kif1bp",null,"0710007C18Rik, 2510003E04Rik, mKIAA1279","MGI:1919570","Kif1bp; KBP",null,null,"10",{"$nulls":28},"Neonatal lethal. Die at birth due to breathing difficulties. Mice display broad peripheral neuropathies, as well as small olfactory bulbs and reduced white mater tracts (anterior commissure).","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-01-19","Cryopreserved sperm"]
[8424,"ASD735:Cannonball:F0","C57BL/6NCrlAnu-Camk2d<em1Anu>/Anu",null,"Recessive","calcium/calmodulin-dependent protein kinase II, delta","Camk2d","Unknown","2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852","MGI:1341265","Camk2d C273s",null,null,"3",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-24","Cryopreserved sperm"]
[8427,"tPA-/-","B6.129-Plat<tm1Mlg>/Mlg",null,"Recessive","plasminogen activator, tissue","Plat","Nil","D8Ertd2e, MGC:18508, tPA, t-PA","MGI:97610","plasminogen activator, tissue; targeted mutation 1, Richard C Mulligan","Plat<tm1Mlg>","MGI:1857288","8",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2018-01-25","Cryopreserved sperm"]
[8425,"RBC21","B6.Cg-Tfrc<RBC21>",null,"Semi-dominant","transferrin receptor","Tfrc","Unknown","2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr","MGI:98822","Tfrc^R654H",null,null,"16",{"$nulls":28},"Homozygous lethal E16.5-18.5 due to profound anaemia.","Mild anaemia, low MCV, high RBC, low Hb.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-25","Cryopreserved sperm"]
[8428,"Wnt11-myrTagRFP-IRES-CE","B6.Cg-Tg(Wnt11-TagRFP/cre/ERT2)28Amc",null,"Dominant",{"$nulls":25},"transgene insertion 28, Andrew McMahon","Wnt11, wingless-type MMTV integration site family, member 11, mouse, laboratory",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-29","Cryopreserved sperm"]
[8430,"RBC16","BALB/c-Cpox<m1Wehi>/WehiMarpApb",null,"Dominant","coproporphyrinogen oxidase","Cpox","Nil","cac, clone 560, Cpo, nct","MGI:104841","Cpox<W373X>",null,null,"16",{"$nulls":28},"Lethal (e9.5) ","Microcytosis (low MCV), low Hb","BALB/c","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-02-02"]
[8429,"mFX knockout","C57Bl/6-F10<F10>/Apb",null,"Recessive","coagulation factor X","F10",null,"AI194738, Cf10, fX","MGI:103107",{"$nulls":3},"8",{"$nulls":28},"Possibly lethal","Normal status","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-31","Cryopreserved sperm"]
[8434,"14-3-3zeta(Gt(OST062)Lex ; Armada","C.129S5-Ywhaz<Gt(OST432062)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST432062, Lexicon Genetics","Ywhaz<Gt(OST432062)Lex>","MGI:4315078","15",{"$nulls":28},"Homozygous KO mice are smaller than their littermate and have behavioural abnormalities, including hyperactivity and congnitive defects. 20% of KO mice die prior to weaning.","Normal","BALB/c","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-02-08","Cryopreserved sperm"]
[8432,"14-3-3zetaGt(OST062)Lex ; Savvy","129(Cg)-Ywhaz<Gt(OST432062)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST432062, Lexicon Genetics","Ywhaz<Gt(OST432062)Lex>","MGI:4315078","15",{"$nulls":28},"Mice have behavioural abnormalities, including hyperactivity and reduced cognitive abilities. KO mice are smaller than their littermates and around 20% die prior to weaning. ","Normal","129/Sv","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-02-08","Cryopreserved sperm"]
[8435,"14-3-3zeta(Gt(OST062)Lex ; Jaxx","B6.129S5-Ywhaz<Gt(OST432062)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST432062, Lexicon Genetics","Ywhaz<Gt(OST432062)Lex>","MGI:4315078","15",{"$nulls":28},"Homozygous animals are smaller than their littermate and have mild hyperactivity and cognitive defects. 20% of KO mice die prior to weaning.","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-02-08","Cryopreserved sperm"]
[8431,"Dmp1Cre.SOCS3f/f","B6-Socs3<tm2Wsa> Tg(Dmp1-cre)1Jqfe/StVApb",null,"Recessive","suppressor of cytokine signaling 3","Socs3",null,"CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":16},"transgene insertion 1, Jian Q Feng","Dmp1","odontoblast-specific expression",{"$nulls":9},"Sex-specific delay in bone corticalization. ","Normal","C75BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-02-06","Cryopreserved sperm"]
[8437,"TREML4 KO","C57BL/6-Treml4<em1>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 4","Treml4","Unknown","5031403H21Rik","MGI:1923239",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-02-16"]
[8438,"TREML4 KO","C57BL/6-Treml4<em2>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 4","Treml4",null,"5031403H21Rik","MGI:1923239",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-02-16"]
[8439,"Tlt2","C57BL/6-Treml2<em1>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 2","Treml2",null,"LOC328833","MGI:2147038",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-02-16","Cryopreserved sperm"]
[8440,"TREML4/TLT2 DKO","C57BL/6-Treml4<em1> Treml2<em1>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 2","Treml2","Unknown","LOC328833","MGI:2147038",{"$nulls":3},"17",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2018-02-16","Cryopreserved sperm"]
[8440,"TREML4/TLT2 DKO","C57BL/6-Treml4<em1> Treml2<em1>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 4","Treml4",null,"5031403H21Rik","MGI:1923239",{"$nulls":3},"17"]
[8436,null,"Actc1-TRE",null,"Dominant",{"$nulls":37},"Unknown",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-02-09","Cryopreserved sperm"]
[8441,"Lx12","B6.129-Abca12<tm1lex>/MarpApb","3528440","Dominant","ATP-binding cassette, sub-family A (ABC1), member 12","Abca12",null,"4832428G11Rik, 4833417A11Rik","MGI:2676312","ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics","Abca12<tm1Lex>","MGI:3528440","1",{"$nulls":28},"Neonatal lethality, epidermal hyperkeratosis, fail to develop epidermal permability barrier, disrupted interstitial lamellar lipid structure, ","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Good","11",null,"heterozygote to wildtype","No","2018-03-05","Cryopreserved sperm"]
[8444,"ASD541:Lifr flox:Flpe:Cre-ERT2","B6(Cg)-Lifr<tm1c(EUCOMM)Hmgu>/AnuApb",null,"Recessive","leukemia inhibitory factor receptor","Lifr",null,"A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788",{"$nulls":3},"15",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-03-09","Cryopreserved sperm"]
[8445,"CTR flox","B6(Cg).129-Calcr<tm1Rda>/AnuApb",null,"Dominant","calcitonin receptor","Calcr",null,"Clr","MGI:101950","calcitonin receptor; targeted mutation 1, Rachel A Davey","Calcr<tm1Rda>","MGI:4352932","6",{"$nulls":28},"Normal.","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">20",null,null,"No","2018-03-14","Cryopreserved sperm"]
[8446,"Choir","C57BL/6NCrlAnu-Fcho1<em1Anu>/AnuApb",null,"Recessive","FCH domain only 1","Fcho1","Unknown","3322402E17Rik","MGI:1921265",{"$nulls":3},"8",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm"]
[8447,"Arpc1b fl","C57BL/6N-Arpc1b<tm1c(EUCOMM)Wtsi> Tg(ACTFLPe)9205Dym/Anu",null,"Recessive","actin related protein 2/3 complex, subunit 1B","Arpc1b","Normal","L72, p41-ARC, SOP2Hs","MGI:1343142","actin related protein 2/3 complex, subunit 1B; targeted mutation 1a, Wellcome Trust Sanger Institute","Arpc1b<tm1c(EUCOMM)Wtsi>",null,"5",{"$nulls":28},"Normal",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm"]
[8448,"W140S","C57BL/6NCrlAnu-Arpc1b<em1Anu>/Anu",null,"Recessive","actin related protein 2/3 complex, subunit 1B","Arpc1b","Normal","L72, p41-ARC, SOP2Hs","MGI:1343142","actin related protein 2/3 complex, subunit 1B; targeted mutation 1a, Wellcome Trust Sanger Institute",null,null,"5",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm"]
[8449,"35bp del","C57BL/6NCrlAnu-Arpc1b<em2Anu>/Anu",null,"Recessive","actin related protein 2/3 complex, subunit 1B","Arpc1b","Normal","L72, p41-ARC, SOP2Hs","MGI:1343142","actin related protein 2/3 complex, subunit 1B; targeted mutation 1a, Wellcome Trust Sanger Institute",null,null,"5",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm"]
[8450,"BALB.931-343","BALB/c-Gasa<C57BL/6(931-343)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2018-03-19","Cryopreserved sperm"]
[8442,"Mdm2<C305F>","B6(Cg).129(Cg)-Mdm2<tm1.1Ypz>/JAnu",null,"Recessive","transformed mouse 3T3 cell double minute 2","Mdm2",null,"1700007J15Rik, Mdm-2","MGI:96952","transformed mouse 3T3 cell double minute 2; targeted mutation 1.1, Yangping Zhang","Mdm2<tm1.1Ypz>","MGI:4836988","10",{"$nulls":28},"Unknown",null,"C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-03-05","Cryopreserved sperm"]
[699,"NID5MD4","NOD-IDD5<C57BL/10> Tg(IghelMD4)4Ccg",null,"Dominant","QTL - Idd5",null,"Unknown",null,null,"insulin dependent diabetes susceptibility 5","Idd5<C57BL/10>","MGI:2389023","1",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow ",null,"High",{"$nulls":9},"This allele confers resistance to insulin dependent diabetes compared to NOD. ",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-01"]
[3411,"Socs3 KO","C57BL/6-Socs3<tm1Wsa>/Wehi",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Nil","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","targeted mutation 1, Warren S Alexander","Socs3<tm1Wsa>","MGI:2180861","11",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal.   SOCS3-/- embryos were slightly smaller than wild type but appeared otherwise normal, and histological analysis failed to detect any anatomical abnormalities responsible for the lethal phenotype. Rather, in all SOCS3-/- embryos examined, defects were evident in placental development that would account for their developmental arrest and death. The placental spongiotrophoblast layer was significantly reduced and accompanied by increased numbers of giant trophoblast cells. Delayed branching of the chorioallantois was evident, and, although embryonic blood vessels were present in the labyrinthine layer of SOCS3-/- placentas, the network of embryonic vessels and maternal sinuses was poorly developed. Yolk sac erythropoiesis was normal, and, although the SOCS3-/- fetal liver was small at day 12.5 of gestation (E12.5), normal frequencies of erythroblasts and hematopoietic progenitor cells, including blast forming unit-erythroid (BFU-E) and, colony forming unit-erythroid (CFU-E) were present at both E11.5 and E12.5. Colony formation for both BFU-E and CFU-E from SOCS3-/- mice displayed wild-type quantitative responsiveness to erythropoietin (EPO), in the presence or absence of IL-3 or stem cell factor (SCF). These data suggest that SOCS3 is required for placental development but dispensable for normal hematopoiesis in the mouse embryo.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14"]
[1742,"C57BL/6 Bak knockout","C57BL/6-Bak<tm1Thsn>/Wehi",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":15},"Yes",{"$nulls":12},"Normal.Increased platelet cell number.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[6715,"TRAILKO","B6.129-Tnfsf10<tm1Mjs>/Ausb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 10 ","Tnfsf10","Nil","A330042I21Rik, APO-2L, Trail ","MGI:107414","tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Mark J Smyth ","Tnfsf10<tm1Mjs>","MGI:2179709","3",{"$nulls":28},"Immune system phenotype:*Defective negative selection of T cells observed in one study is not observed in this study.      Abnormal negative T cell selection:      *Anti-CD3 fails to induce apoptosis of CD4+CD8+ thymocytes in vivo, or in fetal thymic organ culture.      Thymus hyperplasia:      *Mean thymic cellularity is increased about 10% at 6-7 weeks of age.      Increased IgG1 level:      *There are higher levels of antigen-specific IgG1 in mice immunized with collagen compared to controls.      Increased IgG2a level:      *There are higher levels of antigen-specific IgG2a in mice immunized with collagen compared to controls.      Increased interferon-gamma secretion:      *Splenocyte IFN-gamma secretion is enhanced from collagen-immunized mice upon reencounter with antigen compared to controls.      Increased interleukin-2 secretion:      *Splenocyte IL-2 secretion is enhanced from collagen-immunized mice upon reencounter with antigen compared to controls.      Increased susceptibility to autoimmune diabetes:      *Streptozotocin induced diabetes has an earlier onset, higher incidence and is more severe than in controls mice.      *Onset of disease is first detected 20 days after injection compared to over 30 days for controls.      *Incidence reaches 80% versus 40% of controls.      *Insulitis and islet destruction is much more severe than in streptozotocin-injected wild-type mice.      Increased susceptibility to experimental autoimmune encephalomyelitis:      *Mice have increased susceptibility to EAE induced by peptide derived from myelin oligodendrocyte glycoprotein (MOG).      *2 of 6 mice die within 40 days of MOG administration compared to none of the wild-type controls.      *Mean maximal disease score and cumulative disease scores are significantly higher than controls.      Increased susceptibility to induced arthritis:      *Mice develop severe arthritis 4 weeks after collagen immunization compared to C57BL/6 controls that do not develop disease.      *Arthritis is characterized by footpad swelling, pannus formation, cartilage destruction of paw joints.Hematopoietic system phenotype:*Defective negative selection of T cells observed in one study is not observed in this study.      Abnormal negative T cell selection:      *Anti-CD3 fails to induce apoptosis of CD4<+>CD8<+> thymocytes in vivo, or in fetal thymic organ culture.      Thymus hyperplasia:      *Mean thymic cellularity is increased about 10% at 6-7 weeks of age.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[1746,"SOCS-1 KO","C57BL/6-SOCS1<tm1Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs1<tm1Wehi>","MGI:1934607","16",{"$nulls":15},"No",{"$nulls":12},"Postnatal lethality:* homozygotes become ill and die before reaching 3 weeks of age.* mice die from inflammatory disease before weaning.Decreased body weight:* homozygotes become smaller within 10 days after birthPostnatal growth retardation.Pancreas inflammation: monocytic infiltration.Decreased hematocrit.Decreased lymphocyte cell number.Decreased B cell number:* progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood.Decreased pre-B cell number:* pre-B cells are depleted significantly in the marrow.Decreased eosinophil cell number:* moderate reduction in eosinophil numbersAbnormal mature B cell morphology:* number of mature B cells expressing surface Ig in the bone marrow is reduced.Abnormal follicular B cell morphology:* lymphoid follicles of the spleen are either completely absent or are composed of immature cells.Increased spleen red pulp amount:* most spleens show expanded areas of red pulp with nucleated erythroid cells as the main cell population.Thymus cortex hypoplasia:* the cortex becomes progressively depleted of lymphoid cellsSmall thymus.Abnormal Peyer's patch morphology:* Peyer's patches are present but contain few lymphocytes.Abnormal lymph node B cell domain:* lymph nodes show absence of lymphoid follicle formation.Increased inflammatory response:* mice die from massive generalized inflammation that affects multiple organs.Heart inflammation: monocytic, and less frequently, granulocytic infiltration.Pancreas inflammation: monocytic infiltration.Liver inflammation: livers exhibit both focal and generalized infiltration, predominantly by immature and mature monocytic and granulocytic cells, and less frequently, megakaryocytes and eosinophils.Hepatic steatosis: parenchymal cells contain an accumulation of lipid-containing vacuoles.Liver degeneration: fatty degeneration either involves local areas not related to portal vessels or is generalized to the entire liver.Abnormal respiratory alveoli morphology: increase in cellularity of alveolar walls in the lung, often associated with macrophage cuffing around major vessels.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02"]
[5283,"B6.A2AR.KO","C57BL/6-Adora2a<tm1Jfc>",null,"Recessive","adenosine A2a receptor","Adora2a","Nil","A2a, Rs, A2AAR, A2aR, AA2AR","MGI:99402","adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen","Adora2a<tm1Jfc>","MGI:2155985","10",{"$nulls":15},"No",{"$nulls":12},"Impaired behavioral response to addictive substance: * no significant increase in wakefulness is seen in homozygotes after injection of 15 mg/kg, 10 mg/kg, or 5 mg/kg caffeine, unlike wild-type mice. * single exposure amphetamine or cocaine stimulated increases in locomotor activity are reduced compared to wild-type mice. * however, baseline circadian sleep-wake profiles are identical to wild-type. * however, amphetamine stimulated increases in fine movement are not significantly different from wild-type.Hypoactivity: reduced spontaneous activity most prominently in the dark cycle; however normal locomotor circadian rhythms are seen.Decreased susceptibility to ischemic brain injury: 24 hours after middle cerebral arterial occlusion neurological deficit scores for homozygotes are reduced by 50-60% compared to wild-type mice.Decreased cerebral infarction size: after middle cerebral arterial occlusion total infarct volume is reduced by 26% using hematoxylin and eosin staining or by 77% using TTC staining (marker of intact cellular metabolism) compared to wild-type mice.Nervous system phenotype: * morphology of cortex and striatum appears normal. * dopaminergic innervation is normal.Cardiovascular system phenotype: basal mean arterial blood pressure, absolute blood flow, and cortical cerebral blood flow before, during. and after middle cerebral arterial occlusion is similar to wild-type mice.Vision/eye phenotype: normal growth in the anterior segment and normal pupil size.Abnormal sclera morphology: sclera contains denser collagen fibrils with reduced diameter.Myopia: mice develop greater myopia than wild-type mice, that is associated with increases in vitreous chamber depth and axial length from P28 to P56.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28"]
[4783,"WT-286","WT Control for hGM-CSF transgenic mutants",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GM-CSF","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06"]
[773,"NMD4NML5","NOD-Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":10},"Abnormal B cell morphology:* there is no decrease in the number of B cells expressing the transgenic antibody compared to singly transgenic NOD mice that carry just the antibody transgene.* this suggests defect in the NOD strain of deleting B cells that recognize soluble self antigens.Abnormal B cell clonal deletion:* Background Sensitivity: the normal number of B cells found in these mice demonstrate a defect in the NOD strain of deleting B cells that recognize soluble self antigens.Decreased IgM level:* very little IgM is detectable in the sera despite the presence of soluble antigen for the transgenic antibody.Abnormal B cell anergy:* B cells expressing the transgenic antibody are anergic as determined by the lack of HEL specific antibody found in the sera.* anergy occurs both centrally (i.e. in the bone marrow) and in the periphery.* this anergy can be reversed by stimulating B cells in vitro.* when compared to singly transgenic controls, antibody production following BCR and CD40 stimulation is less suppressed in doubly transgenic NOD mice than in doubly transgenic C57BL/6 mice (2.6-fold less vs 4.5 fold less).","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-18"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow",null,"High"]
[6201,"IL-12b","B6.129S1-Il12b<tm1Jm>/J",null,"Recessive","interleukin 12b","Il12b","Nil","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","interleukin 12b; targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls.Decreased circulating interferon-gamma level:*Serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls.Abnormal macrophage physiology:*Fewer than expected macrophages in the dermis of carcinogen treated skin.Abnormal granulocyte physiology:*Fewer than expected granulocytes in the dermis of carcinogen treated skin.Abnormal lymphocyte physiology:*Lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased.      Abnormal NK cell physiology:      *Mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls.      Abnormal CD8-positive T cell physiology:      *Dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin.Decreased susceptibility to type IV hypersensitivity reaction:*Specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type.Decreased interleukin-17 secretion:*Barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17.Increased susceptibility to bacterial infection:*Vaccination does not produce a protective response to M. tuberculosis.Decreased incidence of chemically-induced tumors:*Resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol.*However, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells.Abnormal alveolar process:*3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6675,"FLATLEY","BALB/c-Tg(DO11.10)10Dlo/Ausb",null,"Semi-dominant",{"$nulls":25},"transgene insertion 10, Dennis Y Loh",{"$nulls":11},"Decreased CD4-positive T cell number:*CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide.Decreased double-positive T cell number:*CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide.Abnormal thymus physiology:*20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes.*Apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas.        3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla        peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[819,"Grb10 KO x  Grb14 KO","C57BL/6-Grb10<Gt(Betageo)1Ward> Grb14<tm1Daly>",null,"Recessive","growth factor receptor bound protein 10","Grb10","Nil","5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207","MGI:103232","gene trap 1, Andrew Ward","Grb10<Gt(Betageo)1Ward>","MGI:2668436","11",{"$nulls":15},"Yes",{"$nulls":12},"Double KOs do not show increased insulin signalling over single KOs.Compound KOs exhibit an increase in lean mass.Compound KOs are protected from impaired glucose tolerance that results from high-fat diet whereas sible KOs are not protected.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[819,"Grb10 KO x  Grb14 KO","C57BL/6-Grb10<Gt(Betageo)1Ward> Grb14<tm1Daly>",null,"Recessive","growth factor receptor bound protein 14","Grb14","Nil",null,"MGI:1355324","targeted mutation 1, Roger J Daly","Grb14<tm1Daly>","MGI:3029164","2"]
[5293,"B6-TgN(rtTA2-MUSMRIP7:VEGF-A-TREtight)","C57BL/6-Tg(Ins2-rrTA,tetO-VEGFA)Cpj",null,"Dominant",{"$nulls":25},"reverse tetracycline transactivator (rtTA) ; human vascular endothelial growth factor a","rat insulin 2 gene (RIP7) ; TRE (tetO)",{"$nulls":10},"The mice were not expected to show any overt phenotype. But the transgenic mice are spontaneously diabetic. The onset of diabetes is as early as 3 wks of age and severe in male mice. The transgenic mice are healthy, breed normally and can survive without insulin administration.The genetically modified mice was to be used as islet donors which express angiogenic factor VEGF-A , but the expression will be restricted to islet beta cell and only after doxycycline treatment. The mice constitutively expressing these factors in the pancreas have been reported and do not suffer any detrimental side effects. ",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-29"]
[700,null,"NOD.Cg-Igh-6<tm1Cgn> Tg(IghelMD4)4Ccg/Dvs",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":9},"Do not express endogenous IgM, viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.All B lymphocytes in NOD.Igh-6 deficient transgenic mice express Ig molecules specific for HEL.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-01"]
[3596,null,"C57BL/6-Tg(UBC-GFP)30Scha/J Tg(TcraTcrb)1100Mjb",null,"Recessive",{"$nulls":25},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":11},"Mice with mono-specific T cells repertoire have an impaired immune response but no phenotype expected in a clean housing environment. Transgenic mice on a C57BL/6 background are somewhat immunodeficient, and may be used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Carry OVA-specific, H-2Kb-restricted T cell receptorOT-I mice have an increased thymoma incidence from 4 months of age. These mice express GFP in all tissues examined. Expression levels vary between certain hematapoetic cell types. GFP expression is uniform within a cell type lineage and remains constant throughout development. T cells have a 2-fold higher GFP expression than CD19+B220+ B cells or peripheral blood cells. Leukocytes and red blood cells from homozygous transgenic mice fluoresce at approximately twice the level of cells from hemizygous mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06"]
[{"$nulls":30},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter"]
[4931,"VavP-BCL2-69","CBA-Tg(Vav-BCL2)1Jad/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":10},"Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-19"]
[789,"Y4 KO","B6.129-Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Nil","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14",{"$nulls":15},"Yes",{"$nulls":12},"Decreased body weight:* 4-week old females weigh significantly less than controlsWeight gain:* males and females gain significantly less weight between 4 and 16 weeks of age.Homeostasis/metabolism phenotype:* levels of leptin, insulin, and glucose do not differ from wild type.* testosterone tends to be lower in mutants but this does not become significant.Abnormal circulating pancreatic peptide level:males exhibit 2- to 3-fold higher plasma levels of pancreatic polypeptide (PP).Abnormal drinking behavior:* mutants drink more water during the dark phase, but this is only significant on the second and third days of the 3 day observation period.* this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan.Abnormal water consumption:* daily water intake is elevated only on second and third day compared to controls.* this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan.Abnormal food intake:* males have lower food intake/24 hours than wild type controlsIncreased aggression to other mice:* male mutants show very aggressive behavior, with instances of fighting between littermates causing injuries.* female mutants become aggressive toward littermates after 20-24 weeks of age.Decreased white adipose tissue amount:* male mice have a significantly lower mass of white adipose tissue (WAT) compared to controls.Abnormal fat pad:* mesenteric WAT is major contributor to reduced WAT mass (0.65 % of body weight in male mutant vs 0.84% in male wild type and 0.53% in female mutant vs 0.76% in female wild type).Abnormal mammary gland growth during pregnancy:* lobuloalveolar development is accelerated compared to wild type (lobuloalveolar content on day 16 is 18.74% area of 4th gland compared to 15.79% in wild type).",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19"]
[809,"Y2 KO x Y4 KO","B6.129-Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Nil","NPY-Y2 receptor","MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal bone structure:* periosteal diameter of the cortical shaft is reduced compared to in wild-type mice.Abnormal cancellous bone morphology:* mice exhibit an increase in cancellous bone volume, trabeculae number, and trabecular thickness compared with wild-type mice and single homozygotes.Increased cancellous bone thickness.Decreased cortical bone thickness:* cortical bone area and thickness are decreased compared to in wild-type mice.Abnormal osteogenesis:* mice exhibit increased bone turnover with osteoblast, osteoclast, and osteoid surfaces increased compared with wild-type mice and single homozygotes.* however, osteoblast and osteoclast numbers are normal.Abnormal bone mineralization:* mineral apposition rate is increased compared to in wild-type mice.Abnormal osteoblast physiology:* osteoblast bone formation is increased compared to in wild-type mice.Decreased circulating insulin level:* in male mice compared with wild-type mice.Decreased circulating leptin level:* in male mice compared with wild-type mice and Ppyr1<tm1.1Hhz> homozygotes.Abnormal circulating pancreatic peptide level:* plasma pancreatic peptide levels are increased compared to in wild-type mice.Decreased brown adipose tissue amount.Decreased white adipose tissue amount:* male mice exhibit a decreased in white adipose tissue compared to in wild-type mice or single homozygotes.Decreased body weight:* male mice exhibit decreased body weight compared with wild-type mice that is not as severe as in single homozygotes.Increased eating behavior:* in male mice compared to in wild-type mice and single homozygotes.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21"]
[809,"Y2 KO x Y4 KO","B6.129-Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Unknown","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14"]
[3524,null,"NOD.B6 Idd9D",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 9","Idd9","MGI:96411","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[1733,"BALB/c.EµSV-v-abl 40","BALB/c-Tg(Igh-Abl1)2Sco/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 2, Suzanne Cory","mouse Igh enhancer and the SV40 early promoter",{"$nulls":11},"Start to develop tumours from approx 120 days. Increase incidences of plasmacytoma (symtoms: weight loss, scruffy, respirations rate increases, paralysis of hind legs).Watch for intersusception (intestines fold in on themselves). Comments: At 12 weeks mice will bear one of the following tumours: Splenomegaly, messentery associated, abdominal, dediastinal, caecal, Also problems with small bowel obstruction, intestinal haemorrhage, interssusception, Peyer's Patch.","BALB/c","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[1734,"B6.EµSV-v-abl 40","C57BL/6-Tg(Igh-Abl1)2Sco/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 2, Suzanne Cory ","mouse Igh enhancer and the SV40 early promoter",{"$nulls":11},"Low incidences of plasmacytoma. Look out for dragging hind legs, enlarged spleen, enlarged menteric lymph nodes - tumours. Visually check daily.1-2% will die at 20 weeks of age, 19-20% will die at 1 year. Mice die as a result of plasmcytoma. Mice will bear one of the following tumours: lymphoma, splenomegaly, messentary associated, abdominal, caecal, Peyer's Patches. They may also suffer from small bowel obstruction, intestinal haemorrhage, hind leg paralysis, intussusception.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01"]
[1970,"available from Animal Resources Centre - www.arc.wa.gov.au","C.B10-H2b/LilMcdJArc (BALB/b)",null,"Dominant","Congenic albino: A, Tyr<c>, Tyrp1<b>, Congenic partner BALB/c.",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No",{"$nulls":15},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"Yes","2007-09-04"]
[1765,"Eµ-myc-Caspase-9 knockout","C57BL/6-Tg(IghMyc)22Bri Casp9<tm1Flv>/Wehi",null,"Dominant","caspase 9","Casp9","Nil","Caspase-9, ICE-LAP6, Mch6","MGI:1277950","targeted mutation 1, Richard A Flavell","Casp9<tm1Flv>","MGI:2158755","4",{"$nulls":15},"Yes","transgene insertion 22, Ralph L Brinster","Lymphoid-specific immunoglobulin heavy chain enhancer (Eμ)","B cell lineage",{"$nulls":9},"Due to perinatal lethality, Emu-myc transgenic Apaf-1(-/-) or caspase-9(-/-) fetal liver cells were used to reconstitute lethally irradiated recipient mice. Surprisingly, no differences were seen in rate, incidence, or severity of lymphoma with loss of Apaf-1 or caspase-9, and Apaf-1 was not a critical determinant of anticancer drug sensitivity of c-myc-induced lymphomas. Moreover, loss of Apaf-1 did not promote oncogene-induced transformation of mouse embryo fibroblasts. Thus, Apaf-1 and caspase-9 do not suppress c-myc-induced lymphomagenesis and embryo fibroblast transformation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03"]
[1835,"X linked GFP","Un-Tg(CAG-EGFP)D4Nagy/Wehi",null,"X-linked",{"$nulls":25},"transgene insertion D4, Andras Nagy","chicken beta-actin promoter and CMV intermediate early enhancer","Ubiquitous",{"$nulls":9},"Hemizygous males/Homozygous females will be fluorescent under dertain conditions due to the expression of GFP.  Transgene expression is seen as early as ~E2.75, as morula stage embryos begin to compact. Expression of GFP is spatiotemporally ubiquitous, though levels differ between different lineages (e.g., expression is slightly higher in the heart).",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08"]
[1808,"Oncostatin M Receptor Knockout","C57BL/6-Osmr<tm1Mtan>/Wehi",null,"Recessive","oncostatin M receptor","Osmr","Unknown","OSMRB","MGI:1330819","targeted mutation 1, Minoru Tanaka","Osmr<tm1Mtan>","MGI:2680723","15",{"$nulls":15},"Yes",{"$nulls":12},"Reduced numbers of progenitors of the erythroid and megakaryocyte lineages in bone marrow.Reduced number of peripheral erythrocytes relative to wild type. Reduced number of platelets relative to wild type.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06"]
[1979,"Smad1f x MesP1Cre","B6;Swiss-Smad1<tm2Rob> Mesp1<tm2(cre)Ysa>",null,"Recessive","MAD homolog 1 (Drosophila)","Smad1","Normal","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":15},"No",{"$nulls":12},"Smad 1 deleted in cells expressing MesP1.Conditional deletion of Smad1 in the left lateral plate mesoderm (LPM) led to precocious and bilateral pathway activation.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04"]
[1979,"Smad1f x MesP1Cre","B6;Swiss-Smad1<tm2Rob> Mesp1<tm2(cre)Ysa>",null,"Recessive","mesoderm posterior 1","Mesp1","Normal","bHLHc5","MGI:107785","mesoderm posterior 1; targeted mutation 2, Yumiko Saga","Mesp1<tm2(cre)Ysa>","MGI:2176467","7"]
[6233,"BXK","B6.129-Bak1<tm1Thsn> Bax<tm1Sjk>",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":28},"Partial neonatal lethality:*Majority die within 48 hours of birth, although some survive to adulthood.Interdigital webbing:*Mutants retain interdigital webs on both fore and rear paws.Vagina atresia:*Seen in all adult females.Circling:*Display circling behavior when exposed to external stress.Seizures:*Stress-induced seizure activity.Abnormal hearing physiology:*Unresponsive to auditory stimuli.Abnormal hematopoiesis:*Hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units.      Anemia:      *Mild anemia.      Increased leukocyte cell number:         Increased lymphocyte cell number:         *Increases within the circulation and the peripheral lymphoid organs.         *Lymphocytic infiltration is seen in parenchymal organs, liver, and kidney.      Decreased platelet cell number      Abnormal B cell morphology:      *B220+ B cells present in the lymph node and spleen are skewed toward a B220<bright>IgD- phenotype, indicating an increase in the number of class-switched or memory B cells.      Abnormal T cell morphology:      *T cells that accumulate in mutants are skewed toward a memory cell phenotype.Increased spleen red pulp amount:*Expanded red pulp contains a large increase in the number of plasma cells and histiocytes.Enlarged spleenIncreased spleen white pulp amount:*Pronounced hyperplasiaAbnormal splenocyte physiology:*Isolated splenocytes cultured in suspension show enhanced survival.Enlarged lymph nodesAbnormal brain morphology:*Increase in the number of neurons in multiple regions of the brain.*Large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region.      Increased brain sizeIncreased neuron number:*In multiple regions of the brain.Decreased cellular sensitivity to gamma-irradiation:*Thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation.Decreased physiological sensitivity to xenobiotic:*Thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death.",null,"C57BL/6","No","No","Yes","No","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[6233,"BXK","B6.129-Bak1<tm1Thsn> Bax<tm1Sjk>",null,"Recessive","BCL2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7"]
[2802,"CS-GMCSF MT lme","B6;SJL-Tg(MoMLV-Csf2)/Wehi",null,"Dominant",{"$nulls":25},"colony stimulating factor 2 (granulocyte-macrophage)","Molony murine leukemia virus (MoMLV) long terminal repeat","Haemopoietic specific expression",{"$nulls":9},"Eyes are opaque.  Physical check when cleaning. Pick mouse up by tail. If it is sick the hind legs will not be splayed in a relaxed manner. The sick mouse will be shaking and trying to bring the hind feet together. They will lose weight: coat will get scruff and dull, may shake. Sick mice should be culled.  Will show signs of sickness from 8wks of age.  Exhibit elevated levels of GM-CSF in the serum, urine, peritoneal cavity, and eye. The eyes of transgenic mice are opaque, contain accumulations of macrophages, and develop retinal damage. Similarly, lesions containing macrophages develop in striated muscle. The mice also display an accumulation of large, often multinucleate, activated macrophages in the peritoneal and pleural cavities. The transgene is transcribed in peritoneal cells, as well as in eyes and infiltrated striated muscle. A high proportion of transgenic mice die with muscle wasting when aged 2-4 months, possibly because of macrophage activation resulting from the high levels of GM-CSF.",null,"C57BL/6 x SJL","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-02-22"]
[7096,"Nude","B6-Foxn1<nu>",null,"Recessive","forkhead box N1","Foxn1","Unknown","D11Bhm185e, Hfh11, whn","MGI:102949","nude","Foxn1<nu>","MGI:1856108","11",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:some mice die within 1 week of birth55% mortality within 2 weeksPremature death:100% mortality by 25 weeksDecreased body size and weight.Postnatal growth retardation.Abnormal T cell differentiation.Athymia.Abnormal cell-mediated immunity.Abnormal liver morphology:liver lobes were atrophied and covered with red scarsvariable degrees of severity, typically increasing with age at time of death.Small ovaryCoiled sperm flagellum: many sperm had coiled tailsAbnormal estrous cycle: many females exhibited continuous dioestrus and metaoestrus phasesFemale infertility: severely reduced fertilityReduced male fertility.Asthenozoospermia.Nude: sparse hair growth around 5 weeks of agein some mice, cephalo-caudal migration of an irregular band of short sparse hairThin skin:reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skinAbsent vibrissae: absent at birthShort and wavy vibrissae: older mice show repeated growth and loss of short and wavy vibrissae.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-09-28"]
[6680,"BURKE","BALB/c-Il4ra<tm1Sz>/J/Ausb",null,"Recessive","interleukin 4 receptor, alpha ","Il4ra","Nil","CD124, IL-4 receptor alpha chain, Il4r ","MGI:105367","interleukin 4 receptor, alpha; targeted mutation 1, Leonard Shultz ","Il4ra<tm1Sz>","MGI:1861951","7",{"$nulls":28},"Abnormal microglial cell morphology:*Microglial cells fail to express the cell marker Ym1 (Chi3l3).Decreased IgE level:*Lower circulating levels of IgE in normal and bacterial infected mice.Decreased IgG1 level:*Lower circulating levels in normal and bacterial infected mice.Increased IgG2a levelAbnormal T-helper 2 physiology:*Mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cells.Decreased interleukin-10 secretion:*Decrease production by T cells from mice infected with N. brasiliensis bacteria.Decreased interleukin-4 secretion:*Decrease production of IL-4 by T cells from mice infected with N. brasiliensis bacteria.Decreased interleukin-5 secretion:*Decrease production of IL-5 by T cells from mice infected with N. brasiliensis bacteria.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02"]
[3434,"common beta chain + IL3 beta chain double KO","B6.129-Csf2rb<tm1Csc> Csf2rb2<tm2Cgb>/Wehi",null,"Recessive","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":15},"Yes",{"$nulls":12},"Cells from mice generated with the doublytargeted embryonic stem cells wereunresponsive to GM-CSF, IL3 and IL5 cytokines. Alveolar proteinosis, normal lifespan.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16"]
[3434,"common beta chain + IL3 beta chain double KO","B6.129-Csf2rb<tm1Csc> Csf2rb2<tm2Cgb>/Wehi",null,"Recessive","colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)","Csf2rb2","Unknown","AIC2A, BetaIl3, Bil3, Il3r, Il3rb2","MGI:1339760","colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage); targeted mutation 1, C Glenn Begley","Csf2rb2<tm1Cgb>","MGI:3652583","15"]
[3438,"OPGL KO (RANKL KO)","C57BL/6-Tnfsf11<tm1>",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 11","Tnfsf11","Unknown","Ly109l, ODF, OPG, OPGL, osteoclast differentiation factor, RANKL, Trance","MGI:1100089",{"$nulls":3},"14",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Oesteoporosis, impaired tooth eruption  OPGL mice retarded at 4 weeks of age due to poor nutrition as a result of impaired tooth eruption and oesteoporosis.  Maximal severity of phenotype according to age (juvenile): runted ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16"]
[6239,"B6del/448","B6.C-Bid<tm1.1Ast>",null,"Recessive","BH3 interacting domain death agonist","Bid","Nil","2700049M22Rik","MGI:108093","BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser","Bid<tm1.1Ast>","MGI:4440571","6",{"$nulls":28},"Decreased sensitivity to induced morbidity/mortality:*Unlike wild-type mice that die from fatal hepatitis within 3?4 hr of anti-Fas antibody treatment, all mutants survive.*Homozygous mice develop and age normally and have no increased incidence of tumor development.*Cell subset composition and total cellularity of thymus, spleen, and lymph nodes were normal.Decreased susceptibility to injury:*Animals survive with little or no liver damage and normal serum levels of ALT and AST and normal liver architecture after injection with anti-Fas antibodies.Cellular phenotype:*Unlike other reports, hematopoietic cell and fibroblasts from homozygous mice are normally sensitive to apoptotic stimuli including DNA damage and gamma-irradiation or treatment with etoposide.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13"]
[3451,"Socs7 KO","C57BL/6-Socs7<tm1Wsa>/Wehi",null,"Recessive","suppressor of cytokine signaling 7","Socs7","Nil","2310063P06Rik, Nap4","MGI:2651588","suppressor of cytokine signaling 7; targeted mutation, Warren S Alexander","Socs7<tm1Wsa>","MGI:3487375","11",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mice display partial penetrance of hydroencephaly, premature death (around 50% of homozygotes die between 3-15 weeks of age), mutants fail to eat, intracranial hemorrhage, abnormally large islets of Langerhans and fully penetrant disorganization of the subcommissural organ and reduced body weight.Premature death: around 50% of homozygotes die between 3-15 weeks of age.Aphagia: mutants fail to eat.Hypoactivity: mutants exhibit reduced activity.Lethargy: lethargy is seen with hydroencephaly.Enlarged pancreatic islets: the islets are larger than normal and show more intense insulin staining.Abnormal subcommissural organ morphology: the subcommissural organ is disorganized in the presence or absence of hydroencephaly.Decreased body weight: homozygotes weigh 7-10% less than wild-type littermates from 4 to 14 weeks of age.Intracranial hemorrhage: bleeding on the surface of the brain is seen in some mutants with hydroencephaly.Hydroencephaly: enlargement of the fluid-filled lateral ventricles and in severely affected mutants the fourth ventricle is seenmany areas of the brain are compressed and displaced caudally.Abnormal hippocampus morphology: transition from the retrosplenial cortex to the hippocampus is disrupted in mutants with hydroencephaly.Abnormal cerebral cortex morphology: the cerebral cortex is thinner than normal with less discrete layers in mutants with hydroencephaly.Abnormal cranial suture morphology: mutants with overt hydrocephalus ehxibit a failure of calvarial bone suture closure.Megacephaly.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-18"]
[5556,"T14; IL1RA T14OX","B6;CBA-Tg(Il1rn)1Dih/Anu",null,"Dominant",{"$nulls":25},"transgene insertion 1, David Hirsh","IL1RA promoter",{"$nulls":10},"Increased circulating interleukin-1 level: serum IL-1 levels are higher following lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection.","Abnormal angiogenesis: reduced angiogenesis observed in stromal keratitis caused by herpes simplex virus (HSV) ocular infection, reduced vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) levels.Decreased circulating interleukin-6 level: reduced IL-6 levels in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Abnormal circulating serum amyloid protein level: 30% decrease in serum amyloid P levels after subcutaneous turpentine administration.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.Decreased inflammatory response: reduced polymorphonuclear leukocyte infiltration in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Decreased susceptibility to viral infection: severity of stromal keratitis caused by herpes simplex virus (HSV) ocular infection is diminished.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12"]
[8452,"Hrg KO","B6.129-Hrg<tm1Wja>/WjaAnuApb",null,"Recessive","histidine-rich glycoprotein","Hrg","Nil","D16JH2, D18020","MGI:2146636","histidine-rich glycoprotein; targeted mutation 1, Willi Jahnen-Dechent","Hrg<tm1Wja>","MGI:3789962","16",{"$nulls":28},"Homeostasis/metabolism phenotype:Normal\t• despite abnormalities in coagulation and fibrinolysis no significant differences are detected in skin wound healingAbnormal circulating fibrinogen level:• 35% increase in plasma fibrinogen levels in females compared to wild-type controlsAbnormal blood coagulation:• significant reduction in prothrombin time compared to wild-type controlsAbnormal thrombolysis:• faster spontaneous clot lysisDecreased bleeding time:• in a tail bleed assayIncreased monocyte cell number:• mild",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-27","Cryopreserved sperm"]
[8453,"ASD866:F2","C57BL/6NCrlAnu:Green:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8454,"ASD866:F2","C57BL/6NCrlAnu:Pink:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8455,"ASD866:F2","C57BL/6NCrlAnu:Orange:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"2","No","2018-04-06"]
[8456,"ASD866:F2","C57BL/6NCrlAnu:Yellow:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8457,"ASD867:F2","BALB/cNCrlAnu:Pink:F2",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8458,"ASD867:F2","BALB/cNCrlAnu:Orange:F2",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8459,"ASD867:F2","BALB/cNCrlAnu:Yellow:F2",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8460,"ASD867:F2","BALB/cNCrlAnu:Green:F2",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8461,"ASD872:F2","B6.SJL-Ptprc<a>/CrlAnu:Line A:F2",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":30},"C57BL/6NCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8462,"ASD872:F2","B6.SJL-Ptprc<a>/CrlAnu:Line B:F2",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":30},"C57BL/6NCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06"]
[8463,"ASD598:Albiol:AireKO","B6.129-Aire<tm1Pltn> Hivep2<em1Anu>/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Pltn>","MGI:2182940","10",{"$nulls":28},"Unknown","Unknown","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-06","Cryopreserved sperm"]
[8463,"ASD598:Albiol:AireKO","B6.129-Aire<tm1Pltn> Hivep2<em1Anu>/AnuApb",null,"Recessive","human immunodeficiency virus type I enhancer binding protein 2","Hivep2",null,"Gm20114, MIBP1, Schnurri-2, Shn-2","MGI:1338076",{"$nulls":3},"10"]
[8464,"Heparanase KO:OT-I","B6.129-Hpse<tm1Jpli> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","heparanase","Hpse","Nil","Hpa","MGI:1343124","heparanase; targeted mutation 1, Jin-Ping Li","Hpse<tm1Jpli>","MGI:3844469","5",{"$nulls":16},"transgene insertion 1100, Michael J Bevan",{"$nulls":11},"Heparanase KO mice are fertile with no immunological phenotype observed.","Normal.","C57BL/6JAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-09","Cryopreserved sperm"]
[8465,"Heparanase KO:OT-II","B6.129-Hpse<tm1Jpli> Tg(TcraTcrb)425Cbn/AnuApb",null,"Recessive","heparanase","Hpse","Nil","Hpa","MGI:1343124","heparanase; targeted mutation 1, Jin-Ping Li","Hpse<tm1Jpli>","MGI:3844469","5",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Heparanase KO mice are fertile with no immunological phenotype observed.","Normal.","C57BL/6JAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-09","Cryopreserved sperm"]
[8466,"Heparanase KO:RIP-OVA","B6.129-Hpse<tm1Jpli> Tg(Ins2-OVA)59Wehi/AnuApb",null,"Recessive","heparanase","Hpse","Nil","Hpa","MGI:1343124","heparanase; targeted mutation 1, Jin-Ping Li","Hpse<tm1Jpli>","MGI:3844469","5",{"$nulls":16},"transgene insertion 59, Walter and Eliza Hall Institute of Medical Research","rat insulin 2","High - 49 Copies",{"$nulls":9},"Heparanase KO mice are fertile with no immunological phenotype observed.Mice bearing RIP-OVA transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter.","Normal.","C57BL/6JAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-09","Cryopreserved sperm"]
[8467,"Slp2 KO:Hamlet","B6.129P2-Sytl2<tm1Mitf> Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive","synaptotagmin-like 2","Sytl2","Nil","Slp2, Slp2-a, Slp2-b, Slp2-c, Slp2-d","MGI:1933366","synaptotagmin-like 2; targeted mutation 1, Mitsunori Fukuda","Sytl2<tm1Mitf>","MGI:3693881","7",{"$nulls":16},"transgene insertion 4, Christopher C Goodnow",null,"low copy number",{"$nulls":9},"Abnormal gastric surface mucous cell morphology:• the number of mucus granules is decreased, 2.8-fold fewer granules are docked with the apical membrane, mucus granule size is increased, and irregular apical membranes are frequently observed• however, no clear abnormalities are seen in the thickness of the epithelia or the numbers of parietal, neck, or chief cellsDecreased digestive secretion:• reduced basal mucin secretion by gastric epithelial cells; however when stimulated with A23187 mucus secretion is similar to wild-type cells Transgenic mice, more than 90% of B-cells in the spleen are derived from the transgene (a allotype) and are predominantly IgM and IgD. There is a moderate reduction in B cell frequency and number in spleen and lymph node. B cells did not express Ly-1 or Mac-1. The Ig phenotype of splenic B cells in adult mice (IgMhiIgDlo-hi) resembled that of splenic B cells in non-transgenic 1 - 2-week-old mice.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-09","Cryopreserved sperm"]
[8468,"Tcf7-GFP","C57BL/6-Tcf7<tm1Hhx>/HhxAnu",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1, Hai-Hui Xue","Tcf7<tm1Hhx>","MGI:5805838","11",{"$nulls":28},"Using newly-generated Tcf7GFP reporter mice, we identified novel early innate lymphoid progenitors that express high levels of TCF-1 but lack surface markers of adaptive and innate lymphocyte lineages. These early innate lymphoid progenitors closely resemble bone marrow lymphoid progenitors at the transcriptome level, but lack efficient T and B lymphocyte potential. Instead, they efficiently gave rise to various ILC lineages, including conventional NK cells as well as cytokine-producing helper ILC at the clonal level, indicating that they are the earliest identifiable ILC progenitors. ",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-12","Cryopreserved sperm"]
[8470,"Clec7a KO","B6.129-Clec7a<tm1Gdb>/JAnu",null,"Recessive","C-type lectin domain family 7, member a","Clec7a","Nil","beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1","MGI:1861431","C-type lectin domain family 7, member a; targeted mutation 1, Gordon D Brown","Clec7a<tm1Gdb>","MGI:3695710","6",{"$nulls":28},"Abnormal circulating interleukin level:• IL-22 production in response to Aspergillus fumigatus challenge is severely reducedDecreased circulating interleukin-17 level:• lower levels of IL-17A after lung infection with Aspergillus fumigatusLung inflammation:• impaired inflammatory reactivity of alveolar macrophage• impaired recruitment of macrophage to lungs• highly susceptible to lung infection with Aspergillus fumigatus• little antifungal activity in lung lavage fluidIncreased susceptibility to fungal infection:• highly susceptible to lung infection with Aspergillus fumigatusIncreased sensitivity to induced morbidity/mortality:• mice infected with sublethal dose of C. albicans have much lower survival rate compared to controlsAbnormal neutrophil physiology:• cells do not have beta-glucan dependent recognition of unopsonized zymosan; respiratory burst is attenuated when cultured with unopsonized yeast, and response is not fully restored when opsonized zymosan particles are usedAbnormal macrophage physiology:• thioglycollate-elicited macrophages show impaired recognition of zymosan (fungal beta-glucan particle); prior opsonization with mouse serum restores binding by macrophages• elicited mutant macrophages show impairment of cytokine production when cultured with zymosan• recognition of unopsonized yeast by macrophages is impaired compared to controlsAbnormal cytokine secretion:• mutant macrophages show impaired production of Il10 and Il12 when cultured with zymosanAbnormal inflammatory response:• inflammatory response to zymosan fails to occur; defect is specific for fungal particles as other microbial stimuli elicit a response• inflammatory response to yeast is not restored after opsonization of yeast with mouse serum, although fungal recognition is restored to macrophagesIncreased susceptibility to fungal infection:• mice infected with sublethal dose of C. albicans have much lower survival rate compared to controls• at day 9 after infection, mutant mice have higher fungal burdens than controls in the gastrointestinal tract; enhanced systemic dissemination of C. albicans is evident within 24 hours of infection• at time of death, mutant kidneys show enhanced fungal colonization by C. albicans, particularly in pelvic region with extension up renal tubules compared to controls which lack such colonization• fungal hyphae extend through tubular epithelium into interstitium and are surrounded by acute neutrophilic inflammation (invasive candidiasis)Enlarged stomach:• mice which succumb to infection show macroscopic enlargement of stomachAbnormal digestive system physiology:• mice which succumb to infection have stomachs full of food, suggesting blockage of gastrointestinal tract",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-13"]
[8469,"Sphingosine kinase 2 Knockout ","B6.129S6-Sphk2<tm1Rlp>/RlpUsaApb",null,"Recessive","sphingosine kinase 2","Sphk2",null,null,"MGI:1861380","sphingosine kinase 2; targeted mutation 1, Richard L Proia","Sphk2<tm1Rlp>","MGI:3611080","7",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-12","Cryopreserved sperm"]
[8471,"Pad4 KO","B6.Cg-Padi4<tm1.1Kmow>/JAnu",null,"Recessive","peptidyl arginine deiminase, type IV","Padi4","Nil","Pad4, PAD type IV, Pdi4","MGI:1338898","peptidyl arginine deiminase, type IV; targeted mutation 1.1, Kerri A Mowen","Padi4<tm.1Kmow>","MGI:5285854","4",{"$nulls":28},"Abnormal neutrophil physiology:• neutrophils lack histone deimination unlike wild-type cellsDecreased susceptibility to viral infection:• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice• however, influenza-infected mice exhibit normal survival, neutrophil recruitment into the lung, lung viral titers, and pro-inflammatory cytokine levelsDecreased susceptibility to weight loss:• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-13","Cryopreserved sperm"]
[8473,"Gpx1 KO","B6.129-Gpx1<tm1Kola>/KolaAnu",null,"Recessive","glutathione peroxidase 1","Gpx1","Nil","cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1","MGI:104887","glutathione peroxidase 1; targeted mutation 1, Ismail Kola","Gpx1<tm1Kola>","MGI:2388705","9",{"$nulls":28},"Immune system phenotype:Normal:\t• upon infection with P. berghei ANKA or P. berghei K173, homozygotes show no significant differences in malaria parasite burdens relative to wild-type mice, suggesting normal intraerythrocytic parasite progression and malarial immunityIncreased inflammatory response:• at 24 hrs after cold-induced brain injury, homozygotes exhibit an accelerated neuroinflammatory response, with a significant increase in Mac-1+ cells which rapidly declines by 96 hrs and reappears at 10 days post-injury, suggesting changes in response/activation/recruitment of macrophages and microglia to this type of injuryIncreased neuron apoptosis:• at 24 hrs after ischemia/reperfusion damage in the mid cerebral artery (MCA), homozygotes exhibit increased neuronal apoptosis, as shown by accelerated caspase-3 activation and increased TUNEL staining in post-ischemic mutant brains • at 24 and 96 hrs after cold-induced brain injury, homozygotes display significantly increased neuronal cell death in regions immediately proximal to the infarct core (penumbra)Increased susceptibility to ischemic brain injury :• upon MCA stroke surgery, homozygotes display increased susceptibility to ischemia/reperfusion injury relative to wild-type miceincreased cerebral infarction size ( J:71798 )• in response to ischemia/reperfusion damage in the MCA, homozygotes exhibit a a significantly increased infarct size (area in mm2) relative to wild-type miceCNS ischemia:• in response to ischemia/reperfusion damage in the MCA, homozygotes show an increased neurological deficit score (1.97 vs 0.9) and higher mortality rates (19% vs 7%) relative to wild-type mice, with most mutants dying from severe stroke rather than surgical complications",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-16"]
[8451,"Todr1KO","C57BL/6N-2610318N02Rik<tm1a(EUCOMM)Wtsi>/Wtsi",null,"Recessive","RIKEN cDNA 2610318N02 gene","2610318N02Rik",null,null,"MGI:1917708","RIKEN cDNA 2610318N02 gene; targeted mutation 1a, Wellcome Trust Sanger Institute","2610318N02Rik<tm1a(EUCOMM)Wtsi>","MGI:4451963","16",{"$nulls":28},"Unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-22","Cryopreserved sperm"]
[8472,"MxCreS1P1floxed","B6.Cg-S1pr1<tm2Rlp> Tg(Mx1-cre)1Cgn/UsaApb",null,"Recessive","sphingosine-1-phosphate receptor 1","S1pr1",null,"Edg1, S1P, S1P1","MGI:1096355","sphingosine-1-phosphate receptor 1; targeted mutation 2, Richard L Proia","S1pr1<tm2Rlp>","MGI:2681911","3",{"$nulls":16},"transgene insertion 1, University of Cologne","inducible Mx1",{"$nulls":10},"No phenotype unless the Cre is activated.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-15","Cryopreserved sperm"]
[8474,"ASD598:Albiol:Aire:HIVEP2Indel","B6.129-Aire<em1Anu> Hivep2<em2Anu>/Anuapb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":28},"Unknown","Unknown","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-16","Cryopreserved sperm"]
[8474,"ASD598:Albiol:Aire:HIVEP2Indel","B6.129-Aire<em1Anu> Hivep2<em2Anu>/Anuapb",null,"Recessive","human immunodeficiency virus type I enhancer binding protein 2","Hivep2",null,"Gm20114, MIBP1, Schnurri-2, Shn-2","MGI:1338076",{"$nulls":3},"10"]
[8476,"Tg(Dmp1-cre)1Jqfe. Pthlhtm1Ack","B6.129-Pthlh<tm1Ack> Tg(Dmp1-cre)1Jqfe/SviApb",null,"Recessive","parathyroid hormone-like peptide","Pthlh","Normal","parathyroid hormone-like hormone, parathyroid hormone-related peptide, parathyroid hormone-related protein, PTH-like, PTH-related peptide, Pthrp","MGI:97800","parathyroid hormone-like peptide; targeted mutation 1, Andrew C Karaplis","Pthlh<tm1Ack>","MGI:2387462","6",{"$nulls":16},"transgene insertion 1, Jian Q Feng",{"$nulls":11},"Adult mice had lower trabecular bone mass and lower bone formation. There was no difference in body weight or bone length compared to controls.","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-23","Cryopreserved sperm"]
[3525,"NOD.B6 Idd11C","NOD.B6-Idd11<C57BL/6>",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11; C57BL/6 ","Idd11<C57BL/6>","MGI:3036811","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[7486,"Slc11a1","NOD.B10-Idd5.1<C57BL/10SnJ> Tg(CMV-RNAi:Slc11a1)915Dil/ArcApb",null,"Dominant",{"$nulls":25},"transgene insertion 915, Linda Wicker","cytomegalovirus",null,"insulin dependent diabetes susceptibility 5.1","Idd5.1",null,"Idd5.1, Idd5a","MGI:2158421","insulin dependent diabetes susceptibility 5.1; C57BL/10SnJ","Idd5.1<C57BL/10SnJ>","MGI:3036875","1","The Idd5.1<C57BL/10SnJ> allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac.When challenged with S. enteric, animals expressing RNAi do not survive (7/7). By comparison challenged WT mice were resistant to S. enteric infection (7/8) survived.Diabetes susceptibility is greatly reduced in females expressing Slc11a1 RNAi compared to Idd5.1 female mice not carrying the RNAi transgene.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"GFP positive male to NOD female","No","2013-11-18","Embryo"]
[3523,"NOD.B6 Idd1B","NOD.B6-Idd11<C57BL/6>",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11","Idd11","MGI:3036811","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28"]
[7521,"TgC100.V717F","B6.DBA-Tg(ACTB-APP*V717F)1Colm/ArcApb","B6.DBA-Tg(ACTB-APP*V717F)1Colm/Arc","Dominant",{"$nulls":25},"transgene insertion 1, Colin L Masters","human beta actin","High",{"$nulls":9},"Enhanced behavioral response to addictive substance:• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice.Behavioural despair:• young, but not old, mice exhibit increased immobility during a forced swim test compared with wild-type mice.Abnormal learning/memory/conditioning:• mice exhibit reduced alternation in a Y-maze compared with wild-type mice.Impaired passive avoidance behaviour:• mice exhibit reduced retention in a passive avoidance test compared with wild-type mice.Increased startle reflex:• old, but not young, mice exhibit an increase in startle amplitude compared with wild-type mice.Hyperactivity:• in young, but not old, mice exhibit increased activity in an open field test and entries in an elevated plus maze or Y-maze compared with wild-type mice• at 9 months, mice exhibit slight hyperactivity compared with wild-type mice• however, mice exhibit normal activity levels at 22 monthsInduced hyperactivity:• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice.Abnormal axon morphology.Increased apoptosis:• in CA1 of the hippocampus",null,"C57BL/6 x DBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"26","sib x sib","No","2013-11-29","Embryo"]
[327,"spasmodic oscillator","C57BL/6-Glra1<spd-ot>",null,"Recessive","glycine receptor, alpha 1 subunit","Glra1","Nil","B230397M16Rik, oscillator, ot","MGI:95747","spasmodic oscillator","Glra1<spd-ot>","MGI:1856177","11",{"$nulls":15},"No",{"$nulls":12},"Postnatal lethality:homozygotes die by the end of the third week after birthNervous system phenotype:mice exhibit normal spontaenous glycinergic inhibitory postsynaptic currents in amacrine cellsDecreased neuron number:in mutants there is a reduction or absence of post-inspiratory neurons compared to wild-typeAbnormal nervous system electrophysiology:phrenic nerve discharge patterns of mutant mice vary with respect to burst frequency and duration of expiration and inspiration compared to wild-type mice; mutants displayed more frequent phrenic nerve discharges with shorter, less regular expiratory intervalsMuscle spasm:after rapid breathing episodes, single or multiple whole-body spasms occur with intervals between spasms of 6 seconds to more than 1 minuteAbnormal breathing frequency:conscious mutants (P16-23) display disturbed respiratory patterns characterized by periods of slow breathing and intermittent episodes of rapid breathing; episodes are of variable (2-10 sec).",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2006-05-05"]