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[{"$nulls":17},"Exon",{"$nulls":6},"Intron",null,"Custom"]
["ID","Nickname","Name","Designation","Mode of inheritance","Gene name","Gene symbol","Protein expression of altered gene","Gene synonyms","MGI Gene accession ID","Allele Name","Allele symbol","MGI Allele accession ID","Chromosome","Ensemble Gene ID","Transcript ID","Transcript name","bp coding sequence position","bp cdna sequence position","bp change","Exon ID","Exon number","Amino acid position","Amino acid change","Genomic position","Intron number","Mutation type","Strand type","Coding Sequence","Novelty","Transgene name","Transgene promoter","Transgene expression level","Congenic Gene name","Congenic Gene symbol","Congenic Protein expression of altered gene","Congenic Gene synonyms","Congenic MGI Gene accession ID","Congenic Allele Name","Congenic Allele symbol","Congenic MGI Allele accession ID","Congenic Gene Chromosome","Homozygous phenotype","Heterozygous phenotype","Current genetic background","Female homozygous viable","Female homozygous fertile","Female heterozygotes/hemizygotes fertile","Male homozygous viable","Male homozygous fertile","Male heterozygotes/hemizygotes fertile","Evidence of compromised male fertility","Breeding performance","# generations backcrossed to background strain","# sib-mated generations","Mating scheme","Requires homozygous matings","Date created (dd/mm/yyyy)","Stock stored as","Frozen sperm straw count","Frozen embryo count","Facility Institution","Institutional ID","Restricted access","Project Code","Investigator first name","Investigator last name","institution","email","address","city","state","Depositor first name","Depositor last name","Depositor email","Animal ethics","NLRD","Register With IMSR"]
[1776,"Bim / IL7r Knockout","C57BL/6-Bcl2l11<tm1.1Ast> IL7r<tm1Imx>/Wehi",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Reduced","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"No",{"$nulls":12},"Bim/IL-7Ralpha double deficient mice have significantly increased thymocyte numbers, restored near normal numbers of mature T cells in the blood and spleen, and enhanced cytotoxic T cell responses to virus infection in IL-7Ralpha-/- mice compared to IL7R KO alone. These results indicate that Bim cooperates with other proapoptotic proteins in the death of IL-7-deprived T cell progenitors in vivo, but is the major inducer of this pathway to apoptosis in mature T cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #420","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1776,"Bim / IL7r Knockout","C57BL/6-Bcl2l11<tm1.1Ast> IL7r<tm1Imx>/Wehi",null,"Recessive","interleukin 7 receptor","Il7r","Nil","CD127, IL-7 receptor alpha chain, IL-7Ralpha","MGI:96562","interleukin 7 receptor; targeted mutation 1, Immunex","Il7r<tm1Imx>","MGI:1857198","Unknown",{"$nulls":15},"No",{"$nulls":45},"N/A","N/A"]
[5121,"GDNF+/-","C57BL/6-Gdnf<tm1Lmgd>",null,"Recessive","glial cell line derived neurotrophic factor","Gdnf","Unknown","glial cell line-derived neurotrophic factor","MGI:107430","glial cell line derived neurotrophic factor; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal","Gdnf<tm1Lmgd>","MGI:2136846","15",{"$nulls":15},"No",{"$nulls":12},"Neonatal lethality: die 12-24 hours after birthAbnormal kidney development: * severe renal dysgenesis or renal agenesis * metanephric development is halted between E11 and E14.5Abnormal ureteric bud morphology: ureteric bud is absent in most mice.Absent kidney.Abnormal ureter development: delayed or total absence of ureteric branching in cultured urogenital blocks.Abnormal enteric cholinergic neuron morphology: devoid of enteric parasympathetic cholinergic ganglion cells.Absent enteric neurons: neurons of the myenteric plexus are absent from the intestine.Hypoperistalsis: presence of milk in the oesophagus and reduced progression of food into the gastrointestinal tract.","On 129 background:Abnormal kidney morphology: 35% possess a wide range of renal defects between 3 to 5 months of age.Abnormal kidney development: 12% have severe bilateral kidney dysgenesis.Abnormal ureteric bud morphology: ureteric bud defects.Abnormal ureteric bud branching morphogenesis: reduced ureteric branching in cultured urogenital blocks.Small kidney: 23% have unilateral small kidneys with abnormal shape and/or cortical cysts or rough surface.Single kidney: unilateral kidney agenesis.On 129 x C57BL/6 backgroundPostnatal lethality: * Background Sensitivity: 17.1% preweaning lethality on the C57BL/6 background and 8.4% preweaning lethality on the CD-1 background which increased to 16.7% after interbreeding of offspring on the CD-1 background. * low, but highly significant, preweaning lethalitySingle kidney: 10% exhibit unilateral kidney agenesisAbnormal enteric ganglia morphology * hypoganglionisis, as indicated by reduced numbers and mesh density of ganglionic cells in both the myenteric and the submucosal plexus formations of the gastrointestinal tract. * 64% reduction of ganglionic cells in the ileocecum and colon and 50% reduction in the stomach and small intestine. * exhibit aganglionic regions interspersed along the hypoganglionic regions of the intestine.Megacolon: 84% have varying degrees of colon dilationAbnormal stomach morphology: 38.5% exhibit stomach distention.Chronic constipation: 74% exhibit fecal retention, a sign of chronic constipation.Hypoperistalsis: delayed gastric emptying of milk in newborns, indicating impaired intestinal motility.","C57BL/6","No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2010-05-12","Cryopreserved sperm",40,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[4451,null,"129/SvEv.OLA x C57BL/6",null,"Dominant",{"$nulls":39},"129/Sv x 129/OLA x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-20","Cryopreserved sperm",100,0,"ANU","043","true",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au",{"$nulls":3},"Alistair","Reid","Alistair.Reid@anu.edu.au","N/A","N/A","No"]
[4958,"EGFP<tg1>","C57BL/6-Gt(ROSA)26Sor<tm1(GAP43)Gld> Alpl<tm1(cre)Nagy",null,"Dominant","alkaline phosphatase, liver/bone/kidney","Alpl","Unknown","Akp-2, Akp2, TNAP, TNSALP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Martyn Goulding",{"$nulls":12},"Expression of GFP in all cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-18",null,0,0,null,null,"true",null,"Klaus","Matthaei","The Australian National University","klaus.matthaei@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[705,null,"NOD.B6-Tg(ML5sHEL)5Ccg/Dvs",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 5, Christopher C Goodnow","mouse metallothionein I","High",{"$nulls":9},"Mice homozygous for the TgN(ML5sHEL)5Ccg transgene express a soluble form of hen egg lysozyme.",null,"NOD/lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-02",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Anna ","Chappell","anna.chappell@anu.edu.au","N/A","N/A","No"]
[5277,"MIP-GFP","NOD.Cg-Tg(Ins1-EGFP)1Hara",null,"Dominant",{"$nulls":25},"transgene insertion 1, Manami Hara","mouse insulin 1 gene","High",{"$nulls":10},"The MIP-GFP mice develop normally and are indistinguishable from control animals with respect to glucose tolerance and pancreatic insulin content. Histological studies showed that the MIP-GFP mice had normal islet architecture with coexpression of insulin and GFP in the beta-cells of all islets. Observed GFP expression in islets from embryonic day E13.5 through adulthood.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #389","true",null,"Helen","Thomas","St Vincent's Institute","hhthomas@svi.edu.au",{"$nulls":3},"Helen","Thomas","hthomas@svi.edu.au","N/A","N/A","No"]
[846,"Traf2 KO","C57BL/6-Traf2<tm1.1Rbr>",null,"Recessive","Tnf receptor-associated factor 2","Traf2","Nil",null,"MGI:101835","targeted mutation 1.1, Robert Brink","Traf2<tm1.1Rbr>","MGI:3511496","2",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[6779,"SIGMA-J20","B6.Cg-Tg(PDGFB-APPSwInd)20Lms/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 20, Lennart Mucke ","human platelet derived growth factor, B polypeptide (PDGFB) promoter","highest level of expression occurring in the neocortex and hippocampus",{"$nulls":9},"Unknown","At five to seven months of age diffuse amyloid beta peptides deposition in the dendate gyrus and neocortex forms","C57BL6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","12",null,"hemizygous males are bred to wildtype siblings or to C57BL/6J inbred females. Pups born of carrier females have shown an increased mortality rate in our colonies.","No","2012-01-12",null,0,0,"ABR - Moss Vale","2777","true",null,"John","Kwok","Neuroscience Research Australia","j.kwok@neuro.edu.au",{"$nulls":6},"N/A","N/A","No"]
[226,"129.ZEG","129-Tg(CAG-Bgeo/GFP)21Lbe",null,"Dominant",{"$nulls":25},"transgene insertion 21, Corrinne Lobe","CMV enhancer/chicken beta actin promoter",{"$nulls":10},"Mice that are homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioural abnormalities.  Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages.Expresses enhanced GFP upon Cre-mediated excision.Used as a reporter of Cre-recombinase activity, for either stage-or tissue-specificity, following the excision of the floxed target and activation of the EGFP transgene.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25",null,0,0,null,null,"true",null,"Patrick","Tam","Children's Medical Research Institute","ptam@cmri.usyd.edu.au",{"$nulls":3},"Patrick","Tam","ptam@cmri.usyd.edu.au","N/A","N/A","No"]
[2421,"B10.H2g7","B10.NOD-H2<g7>/AnuApb","B10.NOD-H2<g7>/AnuApb","Recessive","histocompatibility-2, MHC","H2","Normal","H-2, MHC-II","MGI:95894","g7 variant","H2<g7>","MGI:3579321","17",{"$nulls":15},"Yes",{"$nulls":12},"The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component. The g7 variant is found in NOD strain",null,"C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-10","Cryopreserved sperm",129,0,"ANU","213","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[6808,"Dudley","SJL/Mrit-Gck<MRI32652>/MritApb",null,"Dominant","Glucokinase","Gck","Unknown","Gk, hexokinase 4, HK4, MODY2","MGI:1270854","Glucokinase;MRI32562","Gck<MRI32562>",null,"11",{"$nulls":28},"Growth retardationDramatic hyperglycemia","HyperglycemiaHyperinsulinemiaGlucose intolerant","SJL","Yes","No","Yes","Yes","No","Yes","No","Good",{"$nulls":3},"No","2012-02-01","Cryopreserved sperm",60,0,null,null,"false",null,"Gaetan","Burgio","Menzies Research Institute","grburgio@utas.edu.au",{"$nulls":3},"Gaetan","Burgio","grburgio@utas.edu.au","A0101470",null,"No"]
[7634,null,"SJL/ASAM<MRI115171>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",80,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[3536,null,"B6.SJL-Tg(Nes-cre)1Kln",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 1, Rudiger Klein ","rat nestin (Nes)",{"$nulls":10},"Normal.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29",null,0,0,null,"WEHI #1067","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[6655,"HICAM","B6.129S4-Icam1<tm1Jcgr>/J/Ausb",null,"Recessive","intercellular adhesion molecule 1 ","Icam1","Nil","CD54, Icam-1, Ly-47, MALA-2, MGC:6195","MGI:96392","intercellular adhesion molecule 1; targeted mutation 1, Jose Carlos Gutierrez Ramos","Icam1<tm1Jcgr>","MGI:1857292","9",{"$nulls":28},"Abnormal cardiac muscle contractility:*Lipopolysaccharide (LPS) treatment does not result in a decrease in left ventricular contractility as is seen in wild-type, indicating a lack of LPS-induced myocardial dysfunction.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2355","true",null,"Darren","Shafren","Moss Vale","darren.shafren@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4772,"4AT31","ENU4AT:031",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",50,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Stephen","Daley","stephen.daley@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5939,"Nf1bCond/NestinCre/Rosa26",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5938,"Nf1BCond/NesCreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6899,"B6.BlGpA ; B6.TgN(HUFUT1-HUGTA-MUSMICAM2)","C57BL/6-Tg(Icam2-FUT1, GTA)/StV",null,"Dominant",{"$nulls":25},"human H-transferase and human A-transferase","ICAM2",{"$nulls":10},"Expression of human blood group A on vascular endothelium and on a subset of polymorphonuclear cells","Expression of human blood group A on vascular endothelium and on a subset of polymorphonuclear cells","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent","20",null,null,"No","2012-05-24","Cryopreserved sperm",50,0,"St V",null,"true",null,"Cowan","Peter","St Vincent's Hospital Melbourne","peter.cowan@svhm.org.au",{"$nulls":3},"Jennifer","McRae","jennifer.mcrae@svhm.org.au","013","094","No"]
[3924,"CC","BALB/c-Tg(Col1a2-cre/ESR1)7Cpd/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 7, Christopher P Denton","Col1a2 enhancer","fibroblast-specific expression, restricted to collagen",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Backcross to balb/c","No","2008-10-14","Cryopreserved sperm",87,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[211,"NRG1 KO","C57BL/6-Nrg1<tm1Cbm> ",null,"Recessive","neuregulin 1","Nrg1","Unknown","GGF, GGFII, heregulin, HGL, Hgl, HRG, HRGalpha, NDF, SMDF, ARIA","MGI:96083","targeted mutation 1, Carmen Birchmeier","Nrg1<tm1Cbm>","MGI:1928489","8",{"$nulls":15},"No",{"$nulls":12},"Mice die at E10.5 due to severe cardiac defects (lack of cardiac trabeculae). In addition, Schwann cell precursors and cranial ganglia fail to develop normally in NRG1-/- mice.","None reported","C57BL/6J","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[4774,"5AT129","ENU5AT:129",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",60,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Stephen","Daley","stephen.daley@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[6826,"APP KO","B6.129-App<tm1Dbo>/Apb",null,"Recessive","amyloid beta (A4) precursor protein","App","Nil","Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II","MGI:88059","amyloid beta (A4) precursor protein; targeted mutation 1, David R Borchelt","App<tm1Dbo>","MGI:2136847","16",{"$nulls":28},"Abnormal active avoidance behavior: age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age.Abnormal spatial learning: impairment in watermaze test of spatial learning, both at 4 and 10 months of age.Decreased grip strength: significantly reduced grip strength.Abnormal locomotor activation: decreased locomotor activityHypoactivity.Gliosis: reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage.Astrocytosis: reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age.Abnormal neuron morphology: the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus.Abnormal long term potentiation: impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum.Decreased body weight: body weight was 15-20% less at all ages compared with that of controls.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-02-27","Cryopreserved sperm",50,0,null,null,"false",null,"Frances","Corrigan","The University of Adelaide","frances.corrigan@adelaide.edu.au",{"$nulls":6},"BC19/10 ","4/2011","No"]
[4579,null,"SJL.129S7-Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal immune system",null,"SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm",60,0,"ANU",null,"false",null,"David","Willenborg","The Australian National University","david.willenborg@anu.edu.au",{"$nulls":3},"Sue","Fordham","sue.fordham@anu.edu.au","N/A","N/A","No"]
[5279,"MacBlue","NOD.B6-Tg(Csf1r-Gal4VP16/UAS-ECFP)",null,"Dominant",{"$nulls":25},"Gal4VP16 transcriptional activator , enhanced cyan fluorescent protein (ECFP)","Csf1r and Gal4",{"$nulls":10},"Expression of ECFP in macrophages.ECFP expression in transgenic embryos was first detectable at 8 dpc in the blood islands of the proximal yolk sac.ECFP<+> macrophages were concentrated in areas of increased apoptotic cell death, such as necrotic zones of the developing limb, consistent with their proposed scavenger function.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #390","true",null,"Helen","Thomas","St Vincent's Institute","hhthomas@svi.edu.au",{"$nulls":3},"Helen","Thomas","hthomas@svi.edu.au","N/A","N/A","No"]
[7635,null,"SJL/ASAM<MRI131621>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",55,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[6850,"Grhl1KO","C57BL/6-Grhl1<tm1Jane>/MarpApb",null,"Recessive","grainyhead-like 1 (Drosophila)","Grhl1","Nil","LBP-32, p61 MGR, p70 MGR, Tcfcp2l2","MGI:2182540","grainyhead-like 1 (Drosophila); targeted mutation 1, Stephen M Jane","Grhl1<tm1Jane>","MGI:3778923","2",{"$nulls":28},"Homozygous mice are small and have a variable hair phenotype leading to hair loss.Postnatal growth retardation: similar in size at birth and at 2 months of age but significantly smaller than littermate controls at weaning.Cardiovascular system phenotype: unlike human patients with striate palmoplantar keratoderma disorder, no evidence of cardiomyopathy is detected.Alopecia: * over 30% of mice lack hair at weaning with the remainder having sparse coats * extensive regional hair loss is seen when mice are housed with other mice with regrowth when mice are housed alone * despite the thinner coat, in a tape-stripping test more hairs are removed compared to wild-type controls.Delayed hair appearance: delay in coat growth that may be the result of maternal grooming.Sparse hair: * over 30% of mice lack hair at weaning with the remainder having sparse coats * coat remains sparse throughout lifeAbnormal hair follicle morphology: * sections of skin from hypotrichotic regions contain empty cysts in telogen follicles * cleft between the inner and outer root sheath * depilated hairs have a naked anagen bulb lacking the inner and outer root sheathAbnormal epidermal layer morphology: fewer desmosomes are identified in the interfolicular epidermis and unlike in wild-type mice, this number is further reduced after EGTA treatment.Hyperkeratosis: marked thickening of the stratum corneum on the palmoplantar surfaces of the paws.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"+/- x +/-","No","2012-03-14","Cryopreserved sperm",50,0,null,null,"false",null,"Stephen","Jane","Monash University","stephen.jane@monash.edu",{"$nulls":3},"Alana","Auden","alana.auden@monash.edu","08-10864","340/2002","No"]
[4779,"wildtype control","129/Sv-Ifngr(WT)",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Control strain for conducting experiments with 129/Sv-Ifngr1<tm1Agt> strain",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",100,0,null,"ABS #114","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","A.BS.01.09","N/A","No"]
[777,"ID3∆ ID1∆","B6.129-Idd3<-> Idd1<->",null,"Dominant","insulin dependent diabetes susceptibility 3","Idd3","Unknown","Idd-3","MGI:96405",{"$nulls":3},"3",{"$nulls":15},"Yes",{"$nulls":14},"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-18",null,0,0,null,null,"true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"David","James","d.james@garvan.org.au","N/A","N/A","No"]
[777,"ID3∆ ID1∆","B6.129-Idd3<-> Idd1<->",null,"Dominant","insulin dependent diabetes susceptibility 1","Idd1","Unknown","Idd-1","MGI:96400",{"$nulls":3},"17",{"$nulls":58},"David","James","d.james@garvan.org.au","N/A","N/A"]
[5187,null,"ENU18WT:020b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm",40,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[5188,null,"ENU18WT:035b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm",20,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[4919,"CD9 -/-","FVB/N.B6(129)-CD9<Bcx>/AusbApb",null,"Recessive","CD9 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<tm1Bcx>","MGI:2180795","6",{"$nulls":28},"Reduced female fertility: 40 - 50% of females fail to produce litters.Decreased litter size.Impaired fertilization: impaired sperm - egg fusion.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"No","2009-10-20","Cryopreserved sperm",135,0,"ABR - Moss Vale",null,"false",null,"Leonie","Ashman","The University of Newcastle","leonie.ashman@newcastle.edu.au",{"$nulls":3},"Leonie","Ashman","Leonie.Ashman@newcastle.edu.au","N/A","N/A","No"]
[780,"Munc18c KO","C57BL/6-Stxbp3a<tm1Yt>",null,"Recessive","syntaxin binding protein 3A","Stxbp3a","Nil","MGC:86097, Munc-18c, Stxbp3, Sxtbp3","MGI:107362","targeted mutation 1, Yoshikazu Tamori","Stxbp3a<tm1Yt>","MGI:3528591","3",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.Decreased embryo size: at E13.5, homozygous mice are 17% shorter.Decreased birth body size: at birth pups are 30% shorterAbnormal cerebral cortex morphology:* contained poorly formed neural fibers and greater number of cellular components in the intermediate zone of the cerebral cortex.",null,"C57BL/6","No","No","Yes","No","No","Yes","Yes","Poor",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"David","James","d.james@garvan.org.au","N/A","N/A","No"]
[4994,"4AT6","ENU4AT:006",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Gerard","Hoyne","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[7340,"MommeD42","FVB/NJ-Brd1<MommeD42> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","bromodomain containing 1","Brd1","Unknown",null,"MGI:1924161","bromodomain containing 1; modifiers of murine metastable epiallele D42","Brd1<MommeD42>",null,"15","ENSMUSG00000022387","ENSMUST00000109381","Brd1-001",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~10.5 dpc)","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Joanne","Sutton","Queensland Institute of Medical Research","joanne.sutton@qimr.edu.au",{"$nulls":6},"A0812609","P1224/2009","No"]
[2467,null,"B6.CBA-Tg(hGMCSF-KBM)457/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm",40,0,"ANU","191","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[6564,"iNOSΔ","B6.129P2-Nos2<tm1Lau>/JAusb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach","Nos2<tm1Lau>","MGI:1857228","11",{"$nulls":28},"Abnormal surfactant physiology:*Following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice.*Following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice.Abnormal circadian rhythm:*Mice display a more pronounced diurnal variation of sleep-wake activity.Abnormal sleep pattern:*Mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals.*Mice display a more pronounced diurnal variation of sleep-wake activity.*Mice spend less time in non-REM sleep during the dark phase.*During the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration.Abnormal brain wave pattern:*During non-REM sleep the absolute value of slow wave activity is increased.Abnormal inflammatory response:*Unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls.      Decreased inflammatory response:      *Fever in response to LPS injection is partially reduced compared to wild-type controls.      *The fever response to LPS is initiated but not sustained.      *However, fever in response to turpentine injection is not different from controls.",null,"unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo",0,0,"Moss Vale","2589","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7644,null,"B6/Mrit-135904","B6/Mrit-135904","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",33,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7643,null,"SJL/ASAM<MRI115406>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07",null,0,0,null,null,"true",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[709,"NR4ML5","NOD.NOR-(D4Mit31-D4Mit310) Tg(ML5sHEL)5Ccg",null,"Recessive","insulin dependent diabetes susceptibility 9","Idd9","Nil","Idd-9","MGI:96411","NOR/LtJ","Idd9<NOR/LtJ>","MGI:3582457","4",{"$nulls":15},"No","transgene insertion 5, Christopher C Goodnow","mouse metallothionein I","High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[711,"NIHL","NOD-Tg(ILK3mHEL)3Ccg",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Pancreatic islet cells express membrane bound hen egg lysozyme.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[850,"Traf3 floxed","C57BL/6-Traf3<tm1Rbr>",null,"Dominant","Tnf receptor-associated factor 3","Traf3","Normal","CAP-1, CD40bp, CRAF1, LAP1","MGI:108041","targeted mutation 1, Robert Brink","Traf3<tm1Rbr>","MGI:3777324","12",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[4997,"ENU6AT:HELxTCR:line057:CBA:F2 ; Diablo","ENU6AT:57",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Gerard","Hoyne","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5110,"KRN 007 Balb/b F2","KRN:007 BALB/b F2",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Maybe resistant to arthritis induced through serum transfer","Partially resistant to arthritis induced through serum transfer","BALB/b","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2010-05-07","Cryopreserved sperm",29,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Bhavani","Balakishnan","Bhavani.balakishnan@anu.edu.au","J.APF.20.08","N/A","No"]
[5200,"ZIKO ; Zfp397 KO LacZ","STOCK Zfp397<Gt(W131C06)Wrst>/Apb",null,"Recessive","zinc finger protein 397","Zfp397","Nil",null,"MGI:1916506","zinc finger protein 397; gene trap W131C06, German Gene Trap Consortium","Zfp397<Gt(W131C06)Wrst>","MGI:4123642","18",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2010-08-05","Cryopreserved sperm",50,0,null,null,"false",null,"Paul","Kalitsis","Murdoch Childrens Research Institute","paul.kalitsis@mcri.edu.au","Royal Childrens Hospital, Flemington Rd","Parkville","VIC","Sheena","Bailey","sheena.bailey26@gmail.com","A601","153a-2010","No"]
[1760,"Bcl-2-Bcl-w - double knockout","C57BL/6-Bcl2<tm1Dlo> Bcl2l2<tm1Sco>/Wehi",null,"Recessive","B-cell leukemia/lymphoma 2","Bcl2","Nil","Bcl-2","MGI:88138","targeted mutation 1, Dennis Y Loh","Bcl2<tm1Dlo>","MGI:2156165","1",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #315","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1760,"Bcl-2-Bcl-w - double knockout","C57BL/6-Bcl2<tm1Dlo> Bcl2l2<tm1Sco>/Wehi",null,"Recessive","Bcl2-like 2","Bcl2l2","Nil","Bcl-w, bclw, Gtrgal2, Gtrosa41","MGI:108052","targeted mutation 1, Suzanne Cory","Bcl2l2<tm1Sco>","MGI:2158430","14",{"$nulls":61},"N/A","N/A"]
[7595,null,"SJL/ASAM<MRI40265>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","8",null,null,"No","2014-02-18","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[1855,null,"AID-cre-IRES-hCD2t",null,"Recessive",{"$nulls":25},"Cre recombinase","IRES - hCD2 ?",{"$nulls":13},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1448","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5281,"NODGrzA/8.3","NOD.B6-Gzma<tm1Simn> Tg(TcraTcrbNy8.3)1Pesa",null,"Recessive","granzyme A ","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","granzyme A; targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"No","transgene insertion 1, Pere Santamaria","TCR alpha and beta enhancers",{"$nulls":10},"Mice may develop diabetes faster than wildtype.",null,"NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #419","true",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":3},"Helen","Thomas","hthomas@svi.edu.au","N/A","N/A","No"]
[5282,"NODGrzB/8.3","NOD.B6-Gzmb<tm1Ley> Tg(TcraTcrbNy8.3)1Pesa",null,"Recessive","granzyme B ","Gzmb","Nil","CCP-1/C11, CCP1, Ctla-1, Ctla1, GZB","MGI:109267","granzyme B; targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14",{"$nulls":15},"No","transgene insertion 1, Pere Santamaria","TCR alpha and beta enhancers",{"$nulls":10},"Mice may develop diabetes faster than wildtype.",null,"NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #420","true",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":3},"Helen","Thomas","hthomas@svi.edu.au","N/A","N/A","No"]
[7476,"Rhea","FVB/N-MommeD34 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant",null,null,"Reduced",null,null,"modifier of murine metastable epialleles, D34","MommeD34",null,"4",{"$nulls":15},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Mutant mice show a reduction in survival past weaning. Survivors at weaning are smaller than controls.Postnatal lethality: * few animals survive to weaning * normal litter size at birthDecreased body size: at weaning",null,"FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD34<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2013-11-13","Cryopreserved sperm",30,0,"QIMR",null,"false",null,"Joanne","Sutton","Queensland Institute of Medical Research","joanne.sutton@qimrberghofer.edu.au",{"$nulls":6},"P1224A0812609",null,"No"]
[4860,null,"C57BL/6-Tg(H2-K-huCD55,huCD59)/Apb",null,"Dominant",{"$nulls":25},"human CD55/CD59 dual construct","H2-K<b>","ubiquitous",{"$nulls":9},"Expression of membrane bound human CD55 and CD59 in all tissues on all cells.","Expression of membrane bound human CD55 and CD59 in all tissues on all cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",92,0,"St V","009","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","SABC10","94","No"]
[6268,"del511","C57BL/6-Fasl<tm1.1Ast>",null,"Recessive","Fas ligand (TNF superfamily, member 6)","Fasl","Nil","APT1LG1, CD178, CD95L, Fas-L, Tnfsf6","MGI:99255","Fas ligand (TNF superfamily, member 6); targeted mutation 1.1, Andreas Strasser","Fasl<tm1.1Ast>","MGI:4366050","1",{"$nulls":28},"Premature death:*Compared with wild-type mice and Fasl<gld> homozygotes.Immune system phenotype:*Mice mount a normal immune response to influenza.      Enlarged spleen      Increased circulating tumor necrosis factor level:      *At 12 to 20 weeks.      Enlarged lymph nodes      Increased immunoglobulin level         Increased IgA level         Increased IgE level         Increased IgG level            Increased IgG1 level            Increased IgG2a level            Increased IgG2b level         Increased IgM level      Defective cytotoxic T cell cytolysis:      *T cells are less efficient than wild-type cells at killing CH1 cells.      Increased susceptibility to systemic lupus erythematosus:      *62% of terminally ill mice exhibit systemic lupus erythematosus-like (SLE) autoimmune disease with cellular crescents, protein casts, and compliment in renal glomeruli unlike wild-type mice.      *Mice develop more severe SLE-like disease than Fasl<gld> homozygotes.      *By 57 weeks, 50% of mice develop fatal SLE-like autoimmune kidney disease compared with 15% of Fasl<gld> homozygotes.      Increased anti-nuclear antigen antibody level:      *Higher than in wild-type mice and Fasl<gld> homozygotes.         Increased anti-double stranded DNA antibody level:         *Higher than in wild-type mice and Faslgld homozygotes.      Glomerulonephritis:      *Mice develop SLE-like glomerulonephritis unlike wild-type mice and more frequently than Fasl<gld> homozygotes.      Dermatitis:      *30% of mice develop severe dermatitis with lesions on the ears and necks unlike wild-type mice.Increased histiocytic sarcoma incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.Increased liver tumor incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1864","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7255,"MLC:1IGF-1B_2B (Class 1Eb) ; SP1-IGF-1Eb","B6.FVB-Tg(Myl1-SP1/IGF1Ea)1Nros/MarpApb","FVB-Tg(Myl1-SP1/IGF1Ea)1Nros","Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain","skeletal muscle",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu.au",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu.au","MARP-2011-038-BC ","PC1-N54-10","No"]
[6661,"McBride","C;B6-Myd88<tm1Aki>/ANU/Ausb",null,"Recessive","myeloid differentiation primary response gene 88 ","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira ","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":28},"Decreased B cell proliferation:*Splenocytes showed a defect in proliferation in response to the TLR4 ligand lipopolysaccharide (LPS), bacterial lipopeptide (BLP) that signals through the TLR1-TLR2 heterodimer, the TLR9 ligand unmethylated CpG DNA (CpG) and to the TLR7 ligand resiquimod (R-848).Abnormal dendritic cell physiology:*Dendritic cells produced barely detectable amounts of cytokines in response to LPS or CpG.*Dendritic cells mature only in response to LPS but not CpG.Abnormal macrophage physiology:*Activation of NF-kappaB, JNK, p38 and ERK in bone marrow derived macrophages was delayed in response to LPS and absent in response to BLP and CpG.Abnormal NK cell physiology:*NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection.Abnormal T cell physiology:*Thymocytes failed to proliferate in response to IL-1.      Abnormal NK T cell physiology:      *NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection.Abnormal cytokine secretion:*Type 1 IFN, IFNgamma and IL-12 p40 levels are decreased compared to C57BL/6 wild-type controls following sublethal viral infection.*IFNalpha was not secreted after infection with vesicular stomatitis virus (a ssRNA virus).Increased susceptibility to viral infection:*Viral loads and mortality are significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls.Decreased B cell proliferation:*Splenocytes showed a defect in proliferation in response to the TLR4 ligand lipopolysaccharide (LPS), bacterial lipopeptide (BLP) that signals through the TLR1-TLR2 heterodimer, the TLR9 ligand unmethylated CpG DNA (CpG) and to the TLR7 ligand resiquimod (R-848).",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2085","true",null,"Fiona","Eyers","Moss Vale","Fiona.Eyers@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5945,"NfixCond/NestinCre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4924,"IL21 KO","NOD.B6-IL21<tm1Lex>",null,"Recessive","interleukin 21","Il21","Nil",null,"MGI:1890474","targeted mutation 1, Lexicon Genetics","Il21<tm1Lex>","MGI:3528994","3",{"$nulls":15},"No",{"$nulls":12},"Decreased germinal center B cell number:* the percentage of GC B cells that make up the total B cell population in the spleen of immunized mice is reduced by two-thirdsAbnormal CD4-positive T cell morphology:* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Abnormal spleen germinal center morphology:* the number of actively proliferating T cells found within GC is reduced 3- to 4- fold.* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Decreased spleen germinal center number:* there is a paucity of GC in the spleen of mice after immunization with sheep red blood cells (SRBC).Decreased CD4-positive T cell number:* Il-17+ CD4+ cells are absent from lamina propria and spleen in mutants.Abnormal T cell differentiation:* when naive TH cells are subjected to TH17 differentiation, a deficit in generation of Il-17-producing cells is observed with an increased number of Foxp3+ cells compared to wild-type.* one week after immunization with MOG peptide in CFA, restimulation of spleen cells with TPA or MOG peptide results in production of almost no Il-17 producing cells, showing impaired TH17 differentiation.Abnormal gamma-delta T cell morphology:*lamina propria and splenic TCRgd+ T cells show <10-fold decrease in Il-17-expressing cells compared to wild-type cells.Abnormal interleukin level:* CNS-infiltrating and splenic CD4+ T cells produce interferon gamma, in contrast to CD4+ T cells from controls which produce predominantly Il-17.",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-10-29",null,0,0,null,null,"true",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au",{"$nulls":3},"Cecile","King","c.king@garvan.org.au","N/A","N/A","No"]
[3384,"Histamine receptor type 1 -/-","B6.129P2-Hrh1<tm1Wtn>","B6.129P2-Hrh1<tm1Wtn>","Recessive","histamine receptor H1","Hrh1","Nil","Bphs","MGI:107619","targeted mutation 1, Takeshi Watanabe","Hrh1<tm1Wtn>","MGI:2182945","6",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization. Increased responses to papain sensitisation.Increased brown adipose tissue amount:* the amount of brown adipose tissue at 48 weeks of age is increased relative to in wild-type mice.* insulin levels during a 4 week feeding schedule are lower than in mice fed ad libitum.* however, the levels of brown adipose tissue at 12 weeks of age is normal.Increased white adipose tissue amount: at 28 weeks of age, white adipose tissue is increased by 23%, 48% and 40% in the epididymmal, mesenteric and retroperitoneal fat pads, respectively, compared to wild-type mice.Decreased adipose tissue amount: unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased in adiposity.Increased fat cell size:* adipocytes in the epididymal white adipose tissue are larger than in wild-type mice at 48 weeks of age.* however, adipocyte size at 12 weeks of age is normal.Decreased circulating insulin level:* at 48 weeks of age, serum insulin levels are increased relative to in wild-type mice.* however, at 12 weeks of age serum insulin levels are normal.Increased circulating leptin level:* at 48 weeks of age, leptin levels are increased by 66% compared to in wild-type mice.* however, at 12 weeks of age leptin levels are normalIncreased circulating free fatty acid level:* at 48 weeks of age, free fatty acid levels are increased relative to in wild-type mice.* however, at 12 weeks of age free fatty acid levels are normal.Increased triglyceride level: mice exhibit 45% and 20% more triglycerides in the liver and skeletal muscle, respectively, compared to wild-type mice.Abnormal response/metabolism to endogenous compounds: following intracerebroventricular administration of 0.5 ug leptin or intraperitoneal injection of 50 ug of leptin, mice exhibit a smaller decrease in food consumption and body mass relative to wild-type.Decreased body weight:* during 4 week on a feeding schedule, mice fail to gain weight as do wild-type mice despite equivalent food consumption.* unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased body mass.* however, intracerebroventricular administration of methyl(2[2-pyridyl]ethyl)amine dyhydrochloride has no effect on mice.Increased body weight: after 28 weeks of age mice exhibit increased body mass relative to wild-type mice.Increased IgG level: following ovalbumin challenge, IgG1, IgG2a and IgG2b levels are increased relative to similarly treated wild-type mice.Increased IgM level: following ovalbumin challenge, IgM levels are increased relative to similarly treated wild-type mice.Decreased interferon-gamma secretion: antigen stimulation of splenocytes results in the production of less interferon-gamma compared to in similarly treated wild-type mice.Decreased interleukin-13 secretion: antigen stimulation of splenocytes results in the production of less IL-13 compared to in similarly treated wild-type mice.Decreased interleukin-5 secretion: antigen stimulation of splenocytes results in the production of less IL-5 compared to in similarly treated wild-type mice.Decreased inflammatory response:* following challenge with ovalbumin, mice fail to develop lung inflammation as do wild-type mice with fewer eosinophils and lymphocytes detected in the bronchoalveolar lavage.* however, mice exhibit normal B cell immune responses and inhalation of IL-4 or IL-13 induces lung inflammation.Abnormal behavior:* during passive avoidance testing, mice display more frequent urination and defecation and decreased movement compared to wild-type mice.* however, passive avoidance behavior is normal.Abnormal circadian rhythm:* mice exhibit increased locomotor activity during early portions of the light phase and decreased ambulation during the dark phase of a 12 hours light 12 hour dark cycle relative to similarly treated wild-type mice.* the ratio of ambulation during the light phase to total ambulation during 24 hours is increased compared to in wild-type mice.* however, total ambulation during a 24 hours period is normal.Decreased exploration in new environment: despite normal motor coordination, mice exhibit decreased ambulation and time of rearing for the first 30 minutes when placed in a new environment.Decreased vertical activity: mice rear less when placed in a new environment compared to wild-type mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-07-09","Cryopreserved sperm",150,0,null,null,"true",null,"Prue","Hart","Telethon Institute for Child Health Research","prueh@ichr.uwa.edu.au",{"$nulls":3},"Prue","Hart","prueh@ichr.uwa.edu.au","N/A","N/A","No"]
[644,"ATM-pKZ1","C57BL/6-Tg(pKZ1) Atm<tm1Led>",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Unknown","C030026E19Rik","MGI:107202","ataxia telangiectasia mutated homolog (human); targeted mutation 1, Philip Leder","Atm<tm1Led>","MGI:1926875","9",{"$nulls":15},"Yes","β-galactosidase gene (lacZ) E. coli","chicken β-actin",{"$nulls":11},"Irradiated Atm heterozygous knock-out mice did demonstrate fewer inversions after exposure to 15 mGy X-radiation than the Atm normal pKZ1 mice.","C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25",null,0,0,null,null,"true",null,"Pam","Sykes","Flinders University","pam.sykes@flinders.edu.au",{"$nulls":6},"N/A","N/A","No"]
[68,null,"Socks",null,"Recessive",null,null,"Unknown",{"$nulls":5},"4",{"$nulls":15},"Yes",{"$nulls":12},"Dilute coat, white belly spot and \"socks\", small eyes. Unique phenotype for chromosome location, 34 potential genes in this region.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",30,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[6900,"TGFbeta2","STOCK Tgfb2<tm1Doe>/MarpApb",null,"Recessive","transforming growth factor, beta 2","Tgfb2","Nil","Tgfb-2, Tgf-beta2","MGI:98726","transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman","Tgfb2<tm1Doe>","MGI:1888389","1",{"$nulls":29},"TGFb2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects (Sanford et al.,  1997.Development 124, 2659-2670).TGFb2 heterozygotes exhibit a 30% increase in nephron number (Sims-Lucas et al., Pediatr Res. 2008 Jun;63(6):607-12). ","Black Swiss/129/Ola mixed ","No","Unknown","Yes","No","Unknown","Yes","No","Good",null,null,"Heterozygotes are crossed to Wildtypes","No","2012-05-24","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Georgina","Caruana","Monash University","georgina.caruana@monash.edu",{"$nulls":6},"SOBSA/A/2009/57/BC","PC1-N20/12 ","No"]
[4999,"ENU9CAT:G1","ENU9CAT::HelxTCR:CBAxB6",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"No phenotype.Breeding from this G1 male lead to the 9CAT:051 pedigree.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-01","Cryopreserved sperm",10,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","N/A","N/A","No"]
[3535,null,"C57BL/6J-K<btm1>/JWehi",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894",{"$nulls":3},"17",{"$nulls":15},"Yes",{"$nulls":12},"These mice lack one MHC class I molecule, H-2K<b>. Since they still load and express H2D<b>, these mice are able to mount normal CD8 T cell responses to most pathogenes.  They do not show an immuno-compromised phenotype. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29",null,0,0,"WEHI","1050","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[6663,"MORTLOCK","BALB/c.B6-Il13<tm2Anjm>/ANU/Ausb",null,"Recessive","interleukin 13 ","Il13","Nil","Il-13 ","MGI:96541 ","interleukin 13; targeted mutation 2, Andrew NJ McKenzie ","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2094","true",null,"Jay","Horvat","Moss Vale","Jay.Horvat@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6685,"Young","B6.BALB/c-Il5<tm1Kopf>/Ausb",null,"Recessive","interleukin 5 ","Il5","Nil","Il-5 ","MGI:96557","interleukin 5; targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11",{"$nulls":28},"Enlarged placenta:*Knockout females have a significant increase in placenta size in matings with CBA males and the fetal:placental ratio is reduced.Prolonged estrous cycle:*Duration of oestrus in knockouts is moderately extended (5.6 days versus 5 days in controls).Abnormal mating receptivity:*Background Sensitivity: duration of mating interval to achieve mating with syngeneic (B6) versus allogeneic (CBA or BALB/c) males is increased.*After correction for male background, knockout females have significantly lower mating intervals than control females.Increased body weight:*Background Sensitivity: allogeneic matings produce larger pups than syngeneic pups; in CBA F1 pups, at weaning, female and male weights are increased 9.5 and 10%, while in C57BL/6 F1 pups, female and male weights at 6 weeks are increased by 7.9 and 12.2%.*Il5 deficient pups have an increased weight gain trajectory compared to wild-type.*Knockout pups are significantly larger than wild-type pups from birth to adulthood.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2837","true",null,"Paul","Foster","Moss Vale","paul.foster@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6909,"BAC(A33:M2rtTA)","B6;129-Tg(Gpa33-rtTAS*M2)2/LudApb",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane), Gpa33","Mosaic activity in intestinal epithelium",{"$nulls":9},"Not described","The M2rtTA tet transactivator is expressed in the epithelium of the intestine and colon under the control of the intestine-specific A33 promoter. The expression/activety of the transactivator is mosaic, most likely due to stochastic transgene silencing. Approximately 1 to 5 crypts in the proximal small intestine express the transgene, fewer in the distral intestine and colon.","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-06-20","Cryopreserved sperm",50,0,"Ludwig","ME-317","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"015/09","1451/2004","No"]
[4843,null,"ENU6AT:008",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",20,0,null,null,"true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[7048,"FST KO","STOCK Fst<tm1Zuk>/MarpApb",null,"Recessive","follistatin","Fst","Nil",null,"MGI:95586","follistatin; targeted mutation 1, Martin M Matzuk","Fst<tm1Zuk>","MGI:1857467","13",{"$nulls":28},"Lifespan and health is affected.  FS knock-out mice are liveborn, but die within 6 hours of birth due to respiratory failure because of lung and chest muscle defects. These pups display growth retardation, defects of the hard palate and 13th rib, as well as whisker and tooth abnormalities and shiny taut skin.","Normal","C57BL/6 x 129 x FVB","No","No","Yes","No","No","Yes","No","Good",null,null,"Het x Het","No","2012-08-13","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Mark","Hedger","Monash University","mark.hedger@monash.edu",{"$nulls":3},"Rosemary","Genovese","Rosemary.genovese@monash.edu","MMCA 09/37","PC1-N10/11","No"]
[1936,null,"BALB/c-Tg(iFABPp-IL13)/AnuApb",null,"Semi-dominant",{"$nulls":25},"interleukin 13","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP","High",{"$nulls":9},"Restricted expression of IL13 transgene to intestine - duodenum and proximal jejunum.",null,"Balb/c ?","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-29","Cryopreserved sperm",150,0,"ANU","036","false",null,"Paul","Foster","The Australian National University","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4076,null,"ENU6PH:016",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgG1 and IgE response following allergic challenge.",null,"B6 B10 Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm",15,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[6664,"JOHNSON","BALB/c.B6-Tlr2<tm1Aki>/ANU/Ausb",null,"Recessive","toll-like receptor 2","Tlr2","Nil","Ly105","MGI:1346060","toll-like receptor 2; targeted mutation 1, Shizuo Akira","Tlr2<tm1Aki>","MGI:2178675","3",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2107","true",null,"Jay","Horvat","Moss Vale","jay.horvat@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4847,null,"ENU6CAT:050",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",30,0,null,null,"true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[106,"4-1BBL -/-","B6.129Apb-Tnfsf9<tm1Thw>/Apb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 9","Tnfsf9","Nil","4-1BB ligand, 4-1BB-L, 4-1BBL, Cd137l, Ly63l","MGI:1101058","targeted mutation 1, Tania H Watts","Tnfsf9<tm1Thw>","MGI:2179297","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null allele exhibit increased susceptibility to viral infection and defective memory T cell activation.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",119,0,null,null,"true",null,"Edward","Bertram","The Australian National University","edward.bertram@anu.edu.au",{"$nulls":3},"Edward","Bertram","edward.bertram@anu.edu.au","N/A","N/A","No"]
[7648,null,"B6/Mrit-fech","B6/Mrit-fech","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",47,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/017",null,"No"]
[190,null,"S100 beta-dsRed",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes","dsRed","human S100 β gene",{"$nulls":10},"Cells expressing beta S100 express dsRed",null,"Quackenbush","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Brian","Key","The University of Queensland","brian.key@uq.edu.au",{"$nulls":3},"Brian","Key","brian.key@uq.edu.au","N/A","N/A","No"]
[7035,"Osx-Cre p53fl/fl pRbfl/fl","STOCK Rb1<tm3Tyj> Trp53<tm1Brn> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/StvApb",null,"Dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","transformation related protein 53; targeted mutation 1, Anton Berns","Trp53<tm1Brn>","MGI:1931011","11",{"$nulls":16},"Osx-Cre:GFP","Osterix (Sp7)","medium",{"$nulls":9},"Generate osteosarcoma (bone cancer)Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.","Slightly smaller, susceptible to malocclusion. Generate osteosarcoma if p53fl/+ but at long latency (1yr)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Cre+ve males to Cre-ve females, homozygous pRb and p53","No","2012-08-03","Cryopreserved sperm",27,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC 044/10","IBC168","Yes"]
[7035,"Osx-Cre p53fl/fl pRbfl/fl","STOCK Rb1<tm3Tyj> Trp53<tm1Brn> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Nil","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC 044/10","IBC168"]
[5582,"129SvJ/Emx1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5162,"KRN 156","KRN:156",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":16},"transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis, no GPI autoantibodies in KRN/H2g7 model.",null,"C57BL/6J x BALB/b","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-06-28","Cryopreserved sperm",18,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.20.08","N/A","No"]
[4738,null,"B6;Cg-H2<k2> Cbl<tm1Ddlb> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb","B6;Cg-H2<k2> Cbl<tm1Ddlb> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd","Recessive","Casitas B-lineage lymphoma","Cbl","Unknown","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes","transgene insertion 3, Christopher C Goodnow","For Tg(ILK3mHEL)3Ccg: Rat insulin promoter",{"$nulls":10},"Defect in T cell function",null,"B10.BR-H2<k2> x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5","hom x hom","No","2009-04-20","Cryopreserved sperm",105,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Gerard","Hoyne","gerard.hoyne@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis "]
[5195,null,"ENU18WT:017b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm",37,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[7376,"ENU26:032:Birc6","C57BL/6NCrlAnu-Birc6<m1Anu>/AnuApb","C57BL/6NCrlAnu-Birc6<m1Anu>/AnuApb","Recessive","baculoviral IAP repeat-containing 6","Birc6","Unknown","A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik","MGI:1276108","baculoviral IAP repeat-containing 6; mutation 1, The Australian National University","Birc6<m1Anu>","MGI:5563506","17","ENSMUSG00000024073","ENSMUST00000024879","Birc6-201","14218","14475","C to T","ENSMUSE00001248145","71","4740","Glutamine to STOP",{"$nulls":4},"AAGCAACGGTTAAATGGGCTATGCTAGAACAAATCAGAAATCCTTCACCGTGCTTTAAAGA",{"$nulls":13},"Probably embryonic lethal","Unknown","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Good",null,"3","HET x HET","No","2013-07-17","Cryopreserved sperm",36,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"Yes"]
[1987,"Nkx2-3 KO","B6.129-Nkx2-3<tm1Rph>",null,"Recessive","NK2 transcription factor related, locus 3 (Drosophila)","Nkx2-3","Unknown","Nkx-2.3, Nkx2.3, tinman","MGI:97348","targeted mutation 1, Richard P Harvey","Nkx2-3<tm1Rph>","MGI:2448069","19",{"$nulls":15},"No",{"$nulls":12},"Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing.    30% of homozygotes die within the first 2 weeks due to acute intestinal malabsorptionsurviving homozygotes recover rapidly, are fertile, and appear generally healthy as adults.",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5193,null,"ENU18WT:025b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm",30,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[5194,null,"ENU18WT:036a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm",38,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[7649,null,"B6/Mrit-pf","B6/Mrit-pf","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/017",null,"No"]
[7036,"zeta-BALB/c 390 ; 14-3-3 zeta deficient (Line 390)","C.129-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","BALB/c","Yes","No","Yes","Yes","No","Yes","Yes","Good","10",null,"het x het","No","2012-08-06","Cryopreserved sperm",50,0,null,null,"false",null,"Angel","Lopez","SA Pathology","Angel.lopez@health.sa.gov.au",{"$nulls":3},"Hayley","Ramshaw","hayley.ramshaw@health.sa.gov.au","M/236/11","13/2002","No"]
[6792,"A33CreERt2/LacZ13 (ME-223)","STOCK Tg(Gpa33-cre/ERT2) Tg(Pgk1-lacZ)13Vmel/LudApb",null,"Dominant",{"$nulls":25},"cre recombinase","glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","Mixed","No","Unknown","Yes","No","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-01-18","Cryopreserved sperm",45,0,"Ludwig","ME-223","true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"015/09","040/2001 & 304","No"]
[{"$nulls":30},"transgenic insertion 13, Harald von Melchner","mouse Pgk1 promoter"]
[7080,"Momme D40","FVB/NJ-Uhrf1<MommeD40> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","ubiquitin-like, containing PHD and RING finger domains, 1","Uhrf1","Unknown","ICBP90, Np95","MGI:1338889","ubiquitin-like, containing PHD and RING finger domains, 1; modifier of murine metastable epialleles, D40","Uhrf1<MommeD40>",null,"17",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Lethalhomozygous die E10.5","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD40<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-13","Cryopreserved sperm",29,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[6665,"Big Blue","C57BL/6-Tg(TacLIZa)A1Jsh/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion A1, Jay M Short",null,"30 copies of the transgene",{"$nulls":11},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2348","true",null,"John","Aitken","Moss Vale","john.aitken@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[697,"TAG (C3SV40T)","FVB/N-Tg(C3-1-TAg)cJeg",null,"Dominant",{"$nulls":25},"transgene insertion C, Jeffrey E Green","rat prostatic binding protein C3 promoter (Pbpc3)",{"$nulls":11},"Mammary gland hyperplasia: at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice,hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice.Abnormal prostate physiology:prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia.Increased tumor incidence:some mice exhibit mixed tumors of the sweat glands and occasional nasal proliferative or neoplastic lesions develop from the nasal turbinate epithelium unlike in wild-type mice.Adenocarcinoma:at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral and bulbourethral glands unlike in wild-type miceMammary adenocarcinoma:by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice.at 6 months, 10% of female mice exhibit lung metastasis.adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice.Prostate adenocarcinoma:at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice.after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice.the number of apoptotic cells in the prostate is greater than in wild-type mice.at 7 months in the ventral prostate and 11 months in the dorsolateral prostate.however, no metastasis is observed.Prostate intraepithelial neoplasia:at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice.low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice.at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice.high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice.numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice.the number of apoptotic cells in the prostate is greater than in wild-type miceat 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice.at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice.PIN lesions increase with age.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-01",null,0,0,null,null,"true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Chris","Ormandy","c.ormandy@garvan.org.au","N/A","N/A","No"]
[5196,null,"ENU18WT:022a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm",49,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[5284,"B6.CD39.Tg.1079-4.A2AR.KO","C57BL/6-Adora2a<tm1Jfc> Tg(H2-K<b>-Entpd1)",null,"Recessive","adenosine A2a receptor","Adora2a","Nil","A2a, Rs, A2AAR, A2aR, AA2AR","MGI:99402","adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen","Adora2a<tm1Jfc>","MGI:2155985","10",{"$nulls":15},"No","human CD39","H2-K<b>",{"$nulls":10},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #159","true",null,"Karen","Dwyer","St Vincent's Hospital Melbourne","karen.dwyer@svhm.org.au",{"$nulls":3},"Karen","Dwyer","karen.dwyer@svhm.org.au","N/A","N/A","No"]
[1513,"eNOSTg","B6.Cg-Tg(Edn1-NOS3)22Yky/Apb","B6.Cg-Tg(Edn1-NOS3)22Yky/Apb","Dominant",{"$nulls":25},"transgene insertion 22, Mitsuhiro Yokoyama","mouse Edn1","Active in vascular wall",{"$nulls":9},"Hypotension. Elevated cGMP, plasma nitrate and nitrite levels.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","7",null,null,"No","2007-07-04","Cryopreserved sperm",90,0,"ANU","044","false",null,"Caryl","Hill","The Australian National University","caryl.hill@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[3444,"TCR transgenic - CL4","BALB/c-Tg(TcraCl4,TcrbCl4)1Shrm/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1, Linda Sherman","Tcra-V promoter, the immunoglobulin heavy-chain enhancer E(H)",{"$nulls":10},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice. CL4 - Transgenic mice are viable, fertile, normal in size, normoglycemic and do not display any gross physic or behavioral abnormalities.The TCR expressed from this transgene is specific for influenza virus A/PR/8 hemagglutinin (HA) in the context of the MHC class I molecule H2-Kd.  Both thymic and periperal T-cell populations are skewed toward CD8+ cells.  The majority of thymocytes and virtually all CD8+ T cells in lymph nodes express the transgenic TCR beta chain.  About 40% of peripheral blood CD8+ T cells react with the HA peptide presented by H2-Kd.  ",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-17",null,0,0,null,"WEHI #398","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5285,"B6.CD39.Tg.1079-4.CD73.KO","C57BL/6-Nt5e<tm1Lft> Tg(H2-K<b>-Entpd1)",null,"Recessive","5' nucleotidase, ecto","Nt5e","Nil","CD73, ecto-5'-nucleotidase, Nt5","MGI:99782","5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson","Nt5e<tm1Lft>","MGI:3522017","9",{"$nulls":15},"No","human CD39","H2-K<b>",{"$nulls":10},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #174","true",null,"Karen","Dwyer","St Vincent's Hospital Melbourne","karen.dwyer@svhm.org.au",{"$nulls":3},"Karen","Dwyer","karen.dwyer@svhm.org.au","N/A","N/A","No"]
[3471,"C3G genetrap","129-Rapgef1<Gt(pGT1.8geo)5Pgr>/Wehi",null,"Recessive","Rap guanine nucleotide exchange factor (GEF) 1","Rapgef1","Nil","4932418O06Rik, C3G, Grf2","MGI:104580","Rap guanine nucleotide exchange factor (GEF) 1; gene trap 5, Peter Gruss ","Rapgef1<Gt(pGT1.8geo)5Pgr>","MGI:2445403","2",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a gene trap allele exhibit embryonic lethality, altered neuroepithelium morphology, embryonic and extra-embryonic vascular defects, and reduced cell migration and adhesion.","Normal","129/SvPas","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #473","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[7087,"Bim Des RAG","B10.BR.(Cg)-H2<k> Bcl2l11<tm1.1Ast>/Wehi Rag1<tm1> Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd/Apb",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"Yes","transgene insertion 10395, Bernd Arnold",{"$nulls":11},"Similar phenotype as in C57BL/6 mice (Increased numbers of lymphoid and myeloid cells.)Bim-/- females are bad mothers and should not be used for breeding unless necessary.  Bim -/-:  blood - increased lymphocytes (B + T cells), granulocytes & monocytes. - decreased platelets - Increased serum Ig. Des-TCR onto Bim-deficient background can be generated but problems to generate RAG-/- mice. This strain is thus HETEROZYGOUS for RAG deficiency","Unknown","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"Yes","2012-09-20","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":6},"K75/1-2012/3/5632","IBC 02-0024 / PC1NLRD","Yes"]
[7087,"Bim Des RAG","B10.BR.(Cg)-H2<k> Bcl2l11<tm1.1Ast>/Wehi Rag1<tm1> Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd/Apb",null,"Recessive","recombination activating gene 1","Rag1","Normal","Rag-1","MGI:97848",{"$nulls":3},"2",{"$nulls":61},"K75/1-2012/3/5632","IBC 02-0024 / PC1NLRD"]
[6279,"FOX03","B6.129-Foxo3<tm1Nmt>",null,"Recessive","forkhead box O3","Foxo3","Nil","1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a","MGI:1890081","forkhead box O3; targeted mutation 1, Noboru Motoyama","Foxo3<tm1Nmt>","MGI:3719789","10",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*All mice die by 4 weeks after injection with the cell cycle specific myelotoxic drug 5-FU in contrast over 60% of wild-type controls survived.Hematopoietic system phenotype:*Unlike red blood cells, the numbers of white blood cells and platelets and the morphology or myeloid and lymphoid cells are similar to controls.*Proliferation and differentiation of hematopoietic progenitors in the bone marrow are similar to controls.      Decreased erythrocyte cell number      Increased mean corpuscular hemoglobin      Increased mean corpuscular volume      Reticulocytosis      Abnormal hematopoietic stem cell morphology:      *Colony formation in long term culture experiments is severely impaired reflecting a defect in hematopoietic stem cell function.      *Competitive repopulation assays suggest a defect in hematopoietic stem cell self renewal.      *The proportion of cells in G0 is reduced suggesting a defect in quiescence maintenance.      *Reactive oxygen species are elevated.      *Colony formation in short term cultures is reduced for cells from aged mice but not for cells from young mice.         Decreased hematopoietic stem cell number:         *In some aged mice but not in young mice.Female infertility",null,"C57BL/6 X 129/sv","Yes","No","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1241","true",null,"Suzanne","Cory","Walter and Eliza Hall Institute of Medical Research","cory@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5434,"Meio1","Meio1",null,"Recessive","unknown","unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Male infertility due to meiotic arrest in male germ cells.","normal","mixed background (C57BL/6J and CBA)","Yes","Yes","Yes","Yes","No","Yes","Yes","Good",{"$nulls":3},"No","2011-02-15","Cryopreserved sperm",250,0,null,null,"true",null,"Kathleen","Deboer","Monash University","Kathleen.deboer@monash.edu","Department of Anatomy and Developmental Biology","Monash University","Victoria ","Kathleen","Deboer","Kathleen.deboer@monash.edu","SOBSA-A-2009-82BC","N/A","No"]
[4936,"Cathepsin-S Knockout","C6;SJL-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-24",null,0,0,null,"WEHI #456, 457, 458, 468","true",null,"Christopher","Parish","The Australian National University","christopher.parish@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7093,"F/F x Tlr2; gp130Y757F x Tlr2","STOCK Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop gastric and inflammation and tumours, as well as splenomegaly and lymphadenopathy.","If the mice are heterozygous for the gp130 knock-in mutation (F+) then the mice appear normal. ","C57BL/6 x 129Sv x BALB/c","Yes","No","Yes","Yes","Yes","Yes","No","Good","10",null,"heterozogous x homozygous","No","2012-09-26","Cryopreserved sperm",30,0,"Monash",null,"false",null,"Brendan","Jenkins","Monash University","brendan.jenkins@monash.edu",{"$nulls":6},"MMCA ASOP 2008-25","PC1-N06/08","No"]
[7093,"F/F x Tlr2; gp130Y757F x Tlr2","STOCK Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb",null,"Dominant","toll-like receptor 2","Tlr2","Nil","Ly105","MGI:1346060","toll-like receptor 2; targeted mutation 1, Shizuo Akira","Tlr2<tm1Aki>","MGI:2178675","3",{"$nulls":15},"No",{"$nulls":45},"MMCA ASOP 2008-25","PC1-N06/08"]
[349,"PKZ1","C57BL/6-pKZ1",null,"Dominant",{"$nulls":25},"β-galactosidase gene, E. coli (reverse orientation)  flanked by the mouse Vκ21C and Jκ5 immunoglobulin recombination signal sequences","chicken β-actin promoter complex",{"$nulls":10},"Normal.When an inversion event occurs, facilitated by the mouse recombination signal sequences, the lacZ gene is brought into correct juxtaposition with respect to the promoter complex and expression of the E. coli β-galactosidase message can occur (Fig 1). The E. coli β-galactosidase protein can then be detected in tissues in the animals by staining with the chromogenic substrate X-gal. Cells that undergo inversion events exhibit blue staining. The number of inversion events is determined by the ratio of the number of blue staining cells to the total number of cells counted. Inversion events have been detected in a wide range of pKZ1 tissues, with most studies to date concentrating on spleen tissue.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"pKZ1 mice x C57BL/6","No","2006-09-29",null,0,0,null,null,"true",null,"Pam","Sykes","Flinders Medical Centre","pam.sykes@flinders.edu.au",{"$nulls":3},"Pam","Sykes","pam.sykes@flinders.edu.au","N/A","N/A","No"]
[7099,"Fst-oEX","B6;D2-Tg(KRT14-Fst)/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, ","human keratin-14 (K14)",{"$nulls":10},"unknown","only one copy required to demonstrate phenotype.Mice demonstrate larger ears, longer tails, reduced body weight, mild dermal and epidermal atrophy and delayed wound healing","B6D2F2","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Het mouse  x wt mouse","No","2012-10-01","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Mark","Hedger","MIMR-PHI Institute of Medical Research","mark.hedger@monash.edu",{"$nulls":3},"Rosemary","Genovese","rosemary.genovese@monash.edu","A2008/37","pc1-n62/08","No"]
[3940,"C3H.DUB/3","C3Arc.MOLD-Oas1b<Flv-mr>/Arc","C3Arc.MOLD-Oas1b<Flv-mr>Arc","Dominant","2'-5' oligoadenylate synthetase 1B","Oas1b","Normal","Flavivirus resistance, Flv, L1, Mmu-L1, Oias-2, Oias2, Wnv","MGI:97430","minor flavivirus resistance","Oas1b<Flv-mr>","MGI:1857802","5",{"$nulls":15},"No",{"$nulls":12},"Minor resistance to Flavivirus infection.Flv<mr> Phenotype – Resistance to infections by Flaviviruses.Tlr4 Phenotype – Toll 4 receptor is responsive to LPS injection.","Flv<mr> Phenotype – dominant phenotype, heterozygotes are resistant to infection.Tlr4 phenotype is dominant and heterozygous mice show responsiveness to LPS.","C3H/HeJARC","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,"brother x sister","No","2008-10-17",null,0,0,"ARC",null,"true",null,"Geoff","Shellam","The University of Western Australia","nadia@cyllene.uwa.edu.au",{"$nulls":3},"Nadia","Urosevic","nadia@cyllene.uwa.edu.au","N/A","N/A","No"]
[5323,"NfiB Conditional","B6.129-Nfib<tm2Rmg>/Apb",null,"Dominant","nuclear factor I/B","NFib","Reduced",null,"MGI:103188","nuclear factor I/B; targeted mutation 2, Richard M Gronostajski","Nfib<tm2Rmg>","MGI:5052268","4",{"$nulls":28},"Apparently normal. Viable as homozygous mice when not crossed to a Cre expressing line.","Apparently normal. Viable as heterozygous mice when not crossed to a Cre expressing line.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-17","Cryopreserved sperm",44,0,"UQ",null,"false",null,"Linda","Richards","Queensland Brain Institute","richards@uq.edu.au","QBI Building (#79), Upland Road, The University of Queensland","St. Lucia","QLD","Linda","Richards","richards@uq.edu.au","QBI/166/09/BREED/NHMRC/ARC (NF)","NLRD  1595/2005","No"]
[6349,"NPYcre","B6.Cg-Npy<tm1(cre)Tkar>/Ausb",null,"Recessive","neuropeptide Y ","Npy","Nil","0710005A05Rik ","MGI:97374","neuropeptide Y; targeted mutation 1, Tim Karl ","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":28},"Increased anxiety-related response:*Increased levels of anxiety-related behaviors are detected across different test paradigms with males having more pronounced behaviors.*Males have about a two-thirds reduction and females have a third to a half reduction in time spent in the center of an open field.*Male mice but not female mice show a reduced amount of time in the open arm of an elevated maze test.*Mutant males spend less time in the aversive illuminated compartment of a light-dark test with the ratio of distance traveled in lit areas (to total distance traveled) being half that of sex-matched controls.Decreased exploration in new environment:*vertical activities in a new environment are reduced by two-thirds.*Similar results are obtained in an elevated maze test.Decreased vertical activity:*Vertical activities of mutant mice are reduced by two-third in open field testsHypoactivity:*Mice of both sexes have reduced motor activity in an open field tests(371.1 movements vs. 585.5 movements for males).*Both mutant and wild-type female mice have higher locomotion than male mice of the same genotype (479.8 movements vs. 630.7 movements for wild-type females).*Similar results occur in light-dark field tests.*Mutant mice also have longer resting duration time in an open field test (393.3 seconds vs. 347.2 s in wild-type females).*Male mice have increased resting times compared to female mice (462.7s vs. 381.6s).*Similar resting results occur in light-dark field tests.Increased defecation:*Female mice have increased rates of defecation in elevated maze tests (2.8 vs. 0.1 in controls)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2697","true",null,"Paul","Baldock","Garvan Institute","p.baldock@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[3597,null,"C57BL/6-Cd36<tm1Mfe>",null,"Recessive","CD36 antigen","Cd36","Nil","FAT, fatty acid translocase, Scarb3","MGI:107899","targeted mutation 1, Maria Febbraio","Cd36<tm1Mfe>","MGI:1931790","5",{"$nulls":15},"Yes",{"$nulls":12},"Homozgyous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart.  CD36 null mice have elevated fasting levels and cholesterol, triacylglycerol & non-esterfied free fatty acids and lower fasting serum glucose levels.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06",null,0,0,null,"WEHI #1984","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","wheath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6353,"IL27ra","B6.Cg-IL27ra<tm1Fjs>/Ausb",null,"Recessive","interleukin 27 receptor, alpha","Il27ra ","Nil","IL-27R, Tccr, WSX-1 ","MGI:1355318 ","interleukin 27 receptor, alpha; targeted mutation 1, Frederic J de Sauvage","Il27ra<tm1Fjs>","MGI:3525439","8",{"$nulls":28},"Increased lymphocyte cell number:*Increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type.Abnormal T-helper 1 physiology:*amount of interferon-gamma production was decreased per lung-derived CD4 T cell and per antigen-specific CD4 T cell, but not in spleen-derived CD4 T cell, after M. tuberculosis infection.Decreased susceptibility to bacterial infection:*Improved control of Mycobacterium tuberculosis growth and improved reduction of bacterial burden in the lungs, spleen, and draining lymph node.Increased lymphocyte cell number:*Increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2229","true",null,"Marcel","Batten","Garvan Institute","m.batten@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7104,"MT-1/II KO","B6.129-Mt1<Rch> Mt2<Rch>/SaApb",null,"Recessive","metallothionein 1","Mt1","Nil","Mt-1, MT-I","MGI:97171","metallothionein 1; targeted mutation 1, Anna E Michalska","Mt1<tm1Rch>","MGI:2668454","8",{"$nulls":28},"Increased circulating alanine transaminase level: in acetaminophen-treated miceAbnormal ion homeostasis:  * increased cadmium sensitivity * take up a hunched back posture, ruffed coat and display general lethargyAbnormal lipid homeostasis: acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice.Increased sensitivity to xenobiotic induced morbidity/mortality: mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice.Increased physiological sensitivity to xenobiotic: * mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice * acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice * hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells * however, acetaminophen metabolism is normalIncreased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.Abnormal hepatocyte morphology: hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells.Hepatic necrosis: in acetaminophen-treated micetumorigenesis.Increased tumor incidence: 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks).Increased incidence of chemically-induced tumors: increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2012-10-09","Cryopreserved sperm",10,0,null,null,"false",null,"Peter","Coyle","SA Pathology","peter.coyle@health.sa.gov.au",{"$nulls":3},"Carina","Herde","Carina.Cowley@health.sa.gov.au","SA Pathology/CNAHS AEC 2/10","PC1NLRD39/2003","No"]
[7104,"MT-1/II KO","B6.129-Mt1<Rch> Mt2<Rch>/SaApb",null,"Recessive","metallothionein 2","Mt2","Nil","Mt-2, MT-II","MGI:97172","metallothionein 2; targeted mutation 1, Anna E Michalska","Mt2<tm1Rch>","MGI:2668455","8",{"$nulls":58},"Carina","Herde","Carina.Cowley@health.sa.gov.au","SA Pathology/CNAHS AEC 2/10","PC1NLRD39/2003"]
[7663,null,"ENU17China14 ",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Reduced numbers of marginal zone B cells","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-04-11","Cryopreserved sperm",21,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Yovina","Sontani","yovina.sontani@anu.edu.au","A2011/41",null,"No"]
[3487,null,"C57BL/6-IL1rap<tm1Roml>",null,"Recessive","interleukin 1 receptor accessory protein","Il1rap","Unknown","6430709H04Rik, IL-1R AcP, IL-1RAcP","MGI:104975","interleukin 1 receptor accessory protein; targeted mutation 1, Mark A Labow ","Il1raptm1Roml","http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3262","16",{"$nulls":15},"Yes",{"$nulls":12},"Normal.Decreased IL-6 secretion in response to IL-1 injections",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,null,"WEHI #747","true",null,"Ian","Wicks","Walter and Eliza Hall Institute of Medical Research","wicks@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5432,"11B6115b","ENU11B6:115b",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to TB",null,"C57BL/6J x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"6","Sib x sib","No","2011-02-14","Cryopreserved sperm",30,0,"ANU",null,"true",null,"Bernadette","Saunders","Centenary Institute","b.saunders@centenary.usyd.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","APF.14.08","N/A","No"]
[713,"NID5ML5","NOD-Idd5<C57BL/10> Tg(ML5sHEL)5Ccg",null,"Dominant","insulin dependent diabetes susceptibility 5","Idd5","Unknown","Idd-5","MGI:96407","C57BL/10","Idd5<C57BL/10>","MGI:2389023","1",{"$nulls":15},"Yes","transgene insertion 5, Christopher C Goodnow",null,"High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-03",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[7085,"floxed CYP27B1 ","B6.129-Cyp27b1<tm1.1Star>/Apb",null,"Dominant","cytochrome P450, family 27, subfamily b, polypeptide 1","Cyp27b1","Normal","1alpha(OH)ase, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25(OH)D 1alpha-hydroxylase, Cp2b, Cyp1, Cyp27b, Cyp40, P450c1, P450VD1alpha, Pddr, Vdd1, Vddr, VddrI","MGI:1098274","cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1.1, Rene St-Arnaud","Cyp27b1<tm1.1Star>","MGI:2656261","10",{"$nulls":28},"Normal","Normal","C57BL6/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">4",null,null,"No","2012-09-18","Cryopreserved sperm",50,0,null,null,"false",null,"Rachel","Davey","The University of Melbourne","r.davey@unimelb.edu.au","Department of Medicine (AH/NH), University of Melbourne, Level 7, Lance Townsend Building, Studley Road","Heidelberg","Victoria","Rachel","Davey","r.davey@unimelb.edu.au","2012/04565","04561","No"]
[1740,"Aire knockout 384","C57BL/6-Aire<tm1Scot>/Wehi",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Unknown",null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. An increase in the number of activated T cells was evident, and autoantibodies against several organs were detected. At the histological level, lymphocytic infiltration of several organs indicated the development of autoimmunity, although symptoms were mild.Male infertility.They are  immuno-compromised.  They suffer mild  auto-immune disease and the immune response to some infectious agents is impaired.  The -/- C57BL/6 LINE of aireKO mice suffers very mild autoimmune symtoms, particularly in the eye and possibly in the epididymis.  Other strains may have more severe autoimmune symptoms.  Fertility of homozygous males is variable. ","Hetrozygotes are apparently unaffected. ","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,"WEHI","299","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hamish.scott@imvs.sa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[5287,"B6.CD73KO/B6.A2ARKO","C57BL/6-Nt5e<tm1Lft> Adora2a<tm1Jfc>",null,"Recessive","5' nucleotidase, ecto","Nt5e","Nil","CD73, ecto-5'-nucleotidase, Nt5","MGI:99782","5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson","Nt5e<tm1Lft>","MGI:3522017","9",{"$nulls":15},"No",{"$nulls":12},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #406","true",null,"Karen","Dwyer","St Vincent's Hospital Melbourne","karen.dwyer@svhm.org.au",{"$nulls":3},"Karen","Dwyer","karen.dwyer@svhm.org.au","N/A","N/A","No"]
[5287,"B6.CD73KO/B6.A2ARKO","C57BL/6-Nt5e<tm1Lft> Adora2a<tm1Jfc>",null,"Recessive","adenosine A2a receptor","Adora2a","Nil","A2a, Rs, A2AAR, A2aR, AA2AR","MGI:99402","adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen","Adora2a<tm1Jfc>","MGI:2155985","10",{"$nulls":15},"No",{"$nulls":42},"Karen","Dwyer","karen.dwyer@svhm.org.au","N/A","N/A"]
[1551,null,"BALB/c-IL13<tm2Anjm> Tg(iFABPp-IL9)",null,"Recessive","interleukin 13","Il13","Unknown","Il-13","MGI:96541","targeted mutation 2, Andrew NJ McKenzie","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":15},"Yes","interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP  linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences).","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",100,0,null,"ABS #038","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[5290,"CBA/B6/129sv-TgN(HUEPCR)-PAR1 KO","CBA;B6;129-F2r<tm1Ajc> Tg(H2-K<b>-EPCR)",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No","human protein C receptor, endothelial","H2-K<b>","Strong, endothelial cells and neutrophils",{"$nulls":9},"Unknown",null,"C57BL/6 x CBA","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #183","true",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","N/A","N/A","No"]
[3561,null,"C57BL/6-Mnt<fl>",null,"Recessive","max binding protein","Mnt","Normal","Rox","MGI:109150",{"$nulls":3},"11",{"$nulls":15},"No","LoxP, Hygro",{"$nulls":11},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01",null,0,0,null,"WEHI #1348","true",null,"Suzanne","Cory","Walter and Eliza Hall Institute of Medical Research","cory@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","cory@wehi.edu.au","N/A","N/A","No"]
[5291,"B6.EPCR/TBM.Tg.","CBA;B6-Tg(H2-K<b>-TBM) Tg(H2-K<b>-EPCR)",null,"Recessive",{"$nulls":25},"Thrombomodulin","H2-K<b>","Strong, endothelial cells and neutrophils",{"$nulls":9},"Unknown",null,"CBA x C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #184","true",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","N/A","N/A","No"]
[{"$nulls":30},"human protein C receptor, endothelial","H2-K<b>","Strong, endothelial cells and neutrophils"]
[6203,"IFNg","B6.129S7-Ifng<tm1Ts>/J",null,"Recessive","interferon gamma","Ifng    ","Nil","Ifg, IFN-gamma","MGI:107656","interferon gamma; targeted mutation 1, Timothy Stewart ","Ifng<tm1Ts>","MGI:1857184","10",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls.Increased susceptibility to bacterial infection induced morbidity/mortality:*Die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis.Increased susceptibility to parasitic infection induced morbidity/mortality:*Most mice die by 9 days after infection with 1x10<6> Cryptosporidium parvum oocysts.Immune system phenotype:*Do not exhibit defects on either IgE isotype switch or IgE production.      Stomach inflammation:      *5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice.      Increased leukocyte cell number:      *Following infection with BCG.         Increased NK T cell number:         *Unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers.         Increased granulocyte number:         *In the blood, bone marrow and spleen following infection with BCG.         Increased monocyte cell number:         *Following infection with BCG.      Abnormal spleen morphology         Abnormal spleen red pulp morphology:         *Following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue.         Enlarged spleen:         *Develop splenomegaly after infection with BCG.         Abnormal spleen white pulp morphology:         *Following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes.         Pale spleen:         *Spleens become paler as BCG infection proceeds.      Abnormal circulating cytokine level:      *Increase in circulating levels of CSF3 after infection with BCG especially in moribund mice.         Increased circulating interleukin-6 level:         *Following infection with BCG.      Enlarged mesenteric lymph nodes:      *In C. parvum infected mice.      Abnormal dendritic cell physiology:      *Increase in IL12 and decrease in IL10 secretion following LPS stimulation.         Abnormal Langerhans cell physiology:         *Enhancement in hapten induced Langerhan cell migration to the draining lymph nodes.         Abnormal dendritic cell antigen presentation:         *Dendritic cells show a greater ability to stimulate T cell proliferation in vitro.         Abnormal dendritic cell chemotaxis:         *Enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro.         *Enhancement in LPS induced dendritic cell migration to the spleen.      Abnormal macrophage recruitment:      *5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice.      Abnormal type IV hypersensitivity reaction:      *In OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls.         Increased susceptibility to type IV hypersensitivity reaction:         *Display a more severe delayed type hypersensitivity reaction in response to sheep IgG.      Abnormal humoral immune response:      *The magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced.      *However, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels.         Abnormal immunoglobulin level:         *IgG responses are restricted to IgG1 and IgG2b.      Abnormal cytokine secretion:         Decreased interferon-gamma secretion:         *Splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation.         Decreased interleukin-10 secretion:         *Splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen.         *By bone marrow dendritic cells following LPS stimulation.         Increased interleukin-12 secretion:         *By bone marrow dendritic cells following LPS stimulation.         Increased interleukin-4 secretion:         *Splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen.      Abnormal immune tolerance:      *Oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen.      Glomerulonephritis:      *Increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes.      Increased susceptibility to bacterial infection:      *Following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter.      *Following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen.      Increased susceptibility to parasitic infection:      *Background Sensitivity: mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not.      *Background Sensitivity: in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlarged.      Decreased length of allograft survival:      *Decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb.      *Only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice.Increased fear-related response:*Background Sensitivity: increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background.*Prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls.*Make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls.Abnormal response to new environment:*Background Sensitivity: increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background.*The number of rearings is decreased in a novel environment.*Initial locomotor activity is decreased; however, overall distance traveled is not different from controls.Decreased vertical activity:*In a novel environment.Abnormal redox activity:*Unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes.Abnormal urine homeostasis:*1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls.      Albuminuria:      *Increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis.Abnormal nitric oxide homeostasis:*Unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels.Abnormal response to injury:*Decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury.*Fibrotic lesions are sometimes seen after injury.*5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice.      Decreased susceptibility to injury:      *Following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury.      *However, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls.Skeletal muscle fibrosis:*Fibrotic lesions are sometimes seen after injury.Abnormal muscle regeneration:*Decrease in the number and area of regenerating fibers 5 and 10 days after injury.*Fibrotic lesions are sometimes seen after injury.*However, prior to injury no difference in muscle fiber morphology are detected.Stomach inflammation:*5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice.Extramedullary hematopoiesis:*Following infection with BCG.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","115","true",null,"Doug","Hilton","Walter and Eliza Hall Institute of Medical Research","hilton@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1779,"NOD.B6 Idd11A","B6.NOD-Idd11<NOD/ShiLt>/Wehi",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11; NOD/ShiLt","Idd11NOD/ShiLt>","MGI:3036810","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes. It is best to best to begin monitoring development of glycosuria at weekly intervals starting at 10 wks of age.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #894","true",null,"Tom","Brodnicki","Walter and Eliza Hall Institute of Medical Research","brodnicki@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6766,"Ert2/Stat3flox/gp130F ","STOCK Stat3<tm2Aki> Tg(Gpa33-cre/ERT2)/LudApb",null,"Recessive","signal transducer and activator of transcription 3","Stat3","Normal","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 2, Shizuo Akira","Stat3<tm2Aki>","MGI:1926816","11",{"$nulls":16},"cre recombinase","glycoprotein A33 (transmembrane)",{"$nulls":10},"Gastric polyps, maybe developing later and fewer than gp130 ff mice, and maybe additional phenotypes in other tissues.","Unknwon","Mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-16","Cryopreserved sperm",50,0,"Ludwig","ME-233","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","040/2001 & 0304","No"]
[6352,"Y1fCOL3.6?","B6.Cg-Npy1r<tm1wpg> Tg(Col1a1-cre)2Bek/Ausb",null,"Dominant","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","neuropeptide Y receptor Y1; targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":16},"transgene insertion 2, Barbara E Kream","rat Col1a1 promoter",{"$nulls":10},"Increased diameter of femur:*With an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter.Increased bone mineral content:*Whole body and lumbar vertebraeIncreased bone mineral densityIncreased bone trabecula numberIncreased trabecular bone thicknessAbnormal bone ossification:*Bone formation rate in cancellous and cortical bone is increased compared to in wild-type mice.Abnormal osteoblast physiology:*Mice exhibit increased osteoblast activity compared to in wild-type mice.Increased bone strengthIncreased diameter of femur:*With an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter.",null,"Mixed - mice","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","590","true",null,"Paul","Baldock","Garvan Institute","p.baldock@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[1814,"SOCS2 / Ghrhr","Un-Socs2<tm1Wehi> Ghrhr<lit>/Wehi",null,"Recessive","suppressor of cytokine signaling 2","Socs2","Nil","CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2","MGI:1201787","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs2<tm1Wehi>","MGI:1934557","10",{"$nulls":15},"Yes",{"$nulls":12},"The Ghrhr<lit> mutation deletes the SOCS2 -/- phenotype.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #857","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1814,"SOCS2 / Ghrhr","Un-Socs2<tm1Wehi> Ghrhr<lit>/Wehi",null,"Recessive","growth hormone releasing hormone receptor","Ghrhr","Nil","Ghrfr","MGI:95710","little","Ghrhr<lit>","MGI:1856425","6",{"$nulls":61},"N/A","N/A"]
[115,"Ben","C57BL/6JSfdAnu-Tg(IghelMG6)6Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IghelMG6)6Ccg/AnuApb","Dominant",{"$nulls":25},"Low copy number (2H, 2L) anti-HEL transgenic for a chimeric Ig protein (IgM extracellular, and IgG transmembrane and intracellular domains)",null,"High",{"$nulls":9},"B cells express immunoglobulin specific for Hen Egg Lysozyme.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16",null,"No","2006-02-06","Cryopreserved sperm",17,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","AEC","N/A","No"]
[783,"DYN KO","B6.129-Pdyn(tm1(cre)Czer",null,"Recessive","prodynorphin","Pdyn","Nil","Dyn","MGI:97535","targeted mutation 1, Christoph Schwarzer","Pdyn<tm1(cre)Czer>","MGI:3715202","2",{"$nulls":15},"No",{"$nulls":12},"Dyn-/- mice were no different from wild types with regards to body weight and basaland fasting-induced food intake, but fecal output was increased – suggestingdecreased nutrient absorption – and they had significantly less white fat andlost more weight during a 24-hour fast. The neuroendocrine and thermalresponses to fasting were at least as pronounced in Dyn-/- as in wild types, andthere was no stimulatory effect of dynorphin knockout on 24-hour energyexpenditure (kcal heat produced) or physical activity. However, Dyn-/- miceshowed increased circulating concentrations of 3,4-dihydroxyphenlacetic acidand 3,4-dihydroxyphenylglycol, suggesting increased activity of sympatheticnervous system. The respiratory exchange ratio of male but not female Dyn-/-mice was reduced, demonstrating increased fat oxidation. Interestingly,expression of the orexigenic acting neuropeptide Y in the hypothalamic arcuatenucleus was reduced in Dyn-/- mice. However, fasting-induced increases in preprodynorphinexpression in the arcuate nucleus, the paraventricular nucleusand the ventromedial hypothalamus but not the lateral hypothalamus wereabolished by deletion of Y1 but not Y2 receptors. Ablation ofdynorphins results in increases in fatty acid oxidation in male mice, reductionsin adiposity and increased weight loss during fasting",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","8",null,null,"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[784,"NPY KO","B6.129-Npy<tm1(cre)Tkar",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"No",{"$nulls":12},"A significant reduction of food intake after 24 or 48 h fasting.High fat diet did not appear to influence bodyweight or food intake in the NPY knockout young adult NPY knockout mice is the increase (≈30%) in mild seizures when exposed to an unfamiliar environmentsignificant increase in an anxiogenic-like phenotype of these mice NPY−/− mice exhibit significant higher ethanol consumption and lower sensitivity to ethanol compared to control mice with NPY-overexpressing mice showing opposite effects The lack of NPY in NPY−/− mice causes an exaggerated autotomy, a self-mutilation behavior possibly related to pain sensation, in agreement with the analgesic effects of NPY.Increased anxiety-related response:* increased levels of anxiety-related behaviors are detected across different test paradigms with males having more pronounced behaviors.* males have about a two-thirds reduction and females have a third to a half reduction in time spent in the center of an open field.* male mice but not female mice show a reduced amount of time in the open arm of an elevated maze test.* mutant males spend less time in the aversive illuminated compartment of a light-dark test with the ratio of distance traveled in lit areas (to total distance traveled) being half that of sex-matched controls.Decreased exploration in new environment:* vertical activities in a new environment are reduced by two-thirds.* similar results are obtained in an elevated maze test.Decreased vertical activity:* vertical activities of mutant mice are reduced by two-third in open field tests.Hypoactivity:* mice of both sexes have reduced motor activity in an open field tests(371.1 movements vs. 585.5 movements for males)* both mutant and wild-type female mice have higher locomotion than male mice of the same genotype (479.8 movements vs. 630.7 movements for wild-type females)* similar results occur in light-dark field testsmutant mice also have longer resting duration time in an open field test (393.3 seconds vs. 347.2 s in wild-type females)* male mice have increased resting times compared to female mice (462.7s vs. 381.6s).* similar resting results occur in light-dark field testsIncreased defecation:* female mice have increased rates of defecation in elevated maze tests (2.8 vs. 0.1 in controls).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[785,"PYY KO","B6.129-Pyy<tm1(cre)Hhzg>",null,"Recessive","peptide YY","Pyy","Nil",null,"MGI:99924","targeted mutation 1, H Herzog","Pyy<tm1(cre)Hhzg>","MGI:3664105","11",{"$nulls":15},"No","Cre recombinase",{"$nulls":11},"Abnormal body weight:* male mutants do not show significant changes is body weight on a high-fat diet from 4 weeks of age compared to wild type mice.Increased body weight:* on a normal chow diet, female mutants from 4 to 28 weeks of age have significantly increased body weights compared to wild type (area under curve (AUC): wild type, 505g/24 weeks vs Pyy-null, 554g/24 weeks).* females show a marked increase in body weight between 15 and 28 weeks (AUC: mutants 344 g/15-28 weeks; wild type 307.6 g/ 15-28 weeks).Increased susceptibility to age related obesity:* female mutants, not males, develop late-onset obesityIncreased lean body mass:* both 14-week-old male and female mice show a significant increase in whole body lean mass.Increased circulating insulin level:* male and female chow-fed animals show higher serum insulin levels than controls during glucose tolerance test period.* fasting and glucose-induced serum insulin levels are elevated significantly above those observed in wild type mice fed a high fat diet (mutant >200 pmol/l/min vs wild type ~150 pmol/l/min).Increased circulating insulin-like growth factor I level:* male mutants have significantly higher serum levels of IGF-1 when fed a normal chow dietIncreased circulating testosterone level:* in regular chow-fed male mutants, serum testosterone levels are elevated to a statistically significant degree.Impaired glucose tolerance:on a high-fat diet, male mutants are less glucose-tolerant than wild type but difference disappears when data are normalized for bodyweight.Increased white adipose tissue amount:weight of all white fat adipose tissue deposits in females are increased at 28 weeks of age, consistent with increase in body fat.Decreased adipose tissue amount:* females show a decrease in whole body fat mass at 14 weeksIncreased adipose tissue amount:* chow-fed females show a significant 50% increase in fat mass at 28 weeks of age.Abnormal gonadal fat pad:* males fed on a high-fat diet from 4 weeks of age show significant increases in weight of gonadal white fat depositsAbnormal hypothalamus physiology:* 14-week old female mutants show a 51% increase in Pomc expression vs controls in the arcuate nucleus consistent with reduced food intake, while males show a 21% decrease in Npy expression and a 25% increase in Pomc, associated with increased lean mass and serum hormone levels; Ghrh is increased 32% in the ventromedial hypothalamic nucleus of mutants.Behavior/neurological phenotype:* mutants show no alterations in motor activity over a 14 day observation period",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[788,"Y2f","B6.129-Npy2r<tm1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Normal","NPY-Y2 receptor","MGI:108418","targeted mutation 1, Herbert Herzog","Npy2r<tm1Hhz>","MGI:2447395","3",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[1638,"Chloe","C57BL/6-Acan<tm1Afos>",null,"Recessive","aggrecan","Acan","Normal","Agc1, Cspg1","MGI:99602","aggrecan; targeted mutation 1, Amanda J Fosang","Acan<tm1Afos>","MGI:3577026","7",{"$nulls":15},"Yes",{"$nulls":12},"Mutants develop normally with no skeletal abnormalities but do not accumulate aggregan in cartilage even though Agc1 is not cleaved by matrix metalloproteases",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-17",null,0,0,null,null,"true",null,"Amanda","Fosang","Murdoch Childrens Research Institute","amanda.fosang@mcri.edu.au",{"$nulls":3},"Amanda","Fosang","amanda.fosang@mcri.edu.au","N/A","N/A","No"]
[7529,"Sost","C57BL/NTac-Sost<tm1(KOMP)Vlcg/Ausb","C57BL/NTac-Sost<tm1(KOMP)Vlcg/Ausb","Recessive","sclerostin","Sost",null,null,"MGI:1921749","sclerostin; targeted mutation 1, Velocigene","Sost<tm1(KOMP)Vlcg>","MGI:3797839","11",{"$nulls":28},"Skeleton phenotype:\t• mice exhibit normal osteoclast activity.Increased compact bone area.Abnormal osteoblast morphology:• 3-fold increase in bone formation at the distal femur.• increased bone formation at the endocortical surface of the femur midshaft.Abnormal trabecular bone morphology:• lower trabecular separation, increased osteoblast surface and reduced structure model index at 6 months.Increased trabecular bone volume:• at 6 monthsIncreased bone trabecula number:• at 6 monthsIncreased trabecular bone connectivity density:• at 6 monthsIncreased bone mass:• 3-foldAbnormal bone ossification:• 2-fold increase in bone formation at the distal femur.Abnormal bone mineralization:• increased mineral apposition rateAbnormal compact bone morphology:• tibial cortical bone area, bone thickness, and polar moment of inertia are increased compared to in wild-type mice.Increased bone mass:• in the tibiaAbnormal osteoblast physiology:• osteocyte apoptosis is reduced compared to in wild-type mice",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-12-04",null,0,0,"ABR - Moss Vale","3207","true",null,"Peter","Croucher","Garvan Institute","p.croucher@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[3586,"C57BL/6.NOD/Lt-KRN","B6.NOD-Tg(TcraR28,TcrbR28)KRNDim",null,"Dominant",{"$nulls":25},"transgene insertion KRN, Diane Mathis","natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak. These mice develop spontaneous rheumatoid arthritis (RA) joint disease highly reminiscent of man. The trigger for the murine disorder is chance recognition of a NOD-derived major histocompatibility complex (MHC) class II molecule by the transgenic TCR.",null,"C57BL/6 x NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-05",null,0,0,null,"WEHI #1616","true",null,"Ian","Wicks","Walter and Eliza Hall Institute of Medical Research","wicks@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[792,"NPY KO x PYY KO","B6.129-Npy<tm1(cre)Tkar> Pyy<tm1(cre)Hhzg>",null,"Semi-dominant","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"Yes",{"$nulls":12},"Locomotor and exploratory behaviour was decreased in male and female PYY+NPY-/- mice during the photo- and scotophase.Significant decreases in water and food intake were seen in male and female PYY+NPY-/- mice during the photophase.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[792,"NPY KO x PYY KO","B6.129-Npy<tm1(cre)Tkar> Pyy<tm1(cre)Hhzg>",null,"Semi-dominant","peptide YY","Pyy","Nil",null,"MGI:99924","targeted mutation 1, H Herzog","Pyy<tm1(cre)Hhzg>","MGI:3664105","Unknown",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[6678,"ELTON","B6.129S5-Tpsb2<tm1(cre)Adch>/Ausb",null,"Recessive","tryptase beta 2","Tpsb2","Nil","Mcp-6, Mcp6, Mcpt6, MMCP-6 ","MGI:96942","tryptase beta 2; targeted mutation 1, Roberto Adachi","Tpsb2<tm1(cre)Adch>","MGI:3722523","17",{"$nulls":28},"Increased susceptibility to bacterial infection:*A substantially reduced ability to combat K. pneumoniae infections of their peritoneal cavities.*Produced normal-sized litters, showed no obvious developmental abnormality, and had a normal lifespan when maintained in a pathogen-free animal facility.*The peritoneal mast cells showed no substantial alteration in their size or shape or in the numbers, size and density of their secretory granules.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2105","true",null,"Nicole","Hansbro","Moss Vale","nicole.hansbro@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[218,"Pitx2-lacZ","Pitx2-lacZ",null,"Dominant","paired-like homeodomain transcription factor 2","Pitx2","Unknown","Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin","MGI:109340",{"$nulls":3},"3",{"$nulls":15},"Yes","LacZ","Pitx2",{"$nulls":10},"Viable and fertile",null,"C57BL/6 x FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Chrisitne","Biben","biben@wehi.edu.au","N/A","N/A","No"]
[808,"Y2 KO x NPY KO","B6.129-Npy<tm1(cre)Tkar> Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Nil","NPY-Y2 receptor","MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":15},"Yes",{"$nulls":14},"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[808,"Y2 KO x NPY KO","B6.129-Npy<tm1(cre)Tkar> Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[811,"Y1Y5f","B6.129-Npy1r<tm1Wpg> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[811,"Y1Y5f","B6.129-Npy1r<tm1Wpg> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y5","Npy5r","Unknown","Y5R","MGI:108082",{"$nulls":3},"8",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[5632,"B612954 PKd",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6346,"Vavbcl69","C57BL/6-Tg(Vav-BCL2)1Jad",null,"Semi-dominant",{"$nulls":25},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","Overexpression",{"$nulls":9},"Abnormal lymphocyte cell number:*The ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.      Increased B cell number:      *5-fold higher in the spleen at 18 weeks.      Increased T cell number:      *Mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.         Increased CD4-positive T cell number:         *The increase in CD4+ T cells is greater than the increase in CD8+ T cells.         Increased CD8-positive T cell number:         *The increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:*The total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:*22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleenAbnormal spleen germinal center morphology:*Mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.*At 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.*However, expansion of germinal centers is dependent on CD4 T cell help.      Increased spleen germinal center number:      *At 18 weeks.      Increased spleen germinal center size:      *At 18 weeks.Enlarged lymph nodesGlomerulonephritis:*At 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:*12% of mice develop plasma cell tumors.      Increased lymphoma incidence:      *Less than 10% of mice develop lymphoblastic lymphomas.         B cell derived lymphoma:         *Less than 10% of mice develop large cell B lymphomas.            Follicular lymphoma:            *At 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.         Increased histiocytic sarcoma incidence:         *In less than 10% of mice.         Thymic lymphoma:         *In less than 10% of mice.Abnormal renal glomerular capsule:*Bowman epithelium proliferates to form crescents in the most advanced cases.Abnormal renal glomerulus morphology:*Mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits.*Most capillaries are no longer patent.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","55","true",null,"David","Huang","Walter and Eliza Hall Institute of Medical Research","huang_d@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7046,"FST Flox","B6.129-Fst<tm2Zuk>/MarpApb",null,"Dominant","follistatin","Fst",null,null,"MGI:95586","follistatin; targeted mutation 2, Martin M Matzuk","Fst<tm2Zuk>","MGI:3040645","13",{"$nulls":28},"Normal","Normal","C57BL/6J x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-08-13","Cryopreserved sperm",70,0,"Monash",null,"false",null,"Mark","Hedger","Monash University","mark.hedger@monash.edu",{"$nulls":3},"Rosemary ","Genovese","Rosemary.genovese@monash.edu","MMCA 09/24","PC1-N27/09","No"]
[3425,"Crlf1 KO","B6.129-Crlf1<tm1Wsa>/Wehi",null,"Recessive","cytokine receptor-like factor 1","Crlf1","Nil","CLF-1, CRLM3, cytokine receptor like molecule 3, NR6.1","MGI:1340030","targeted mutation 1, Warren S Alexander","Crlf1<tm1Wsa>","MGI:2387956","8",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.Neonatal lethality: at birth, homozygotes are present at the expected Mendelian frequency; however, no homozygotes survive beyond 24 hrs after birth.Absent gastric milk in neonates: newborn homozygotes contain no milk in their stomachs.Abnormal suckling behavior: newborn homozygotes open and close their mouths but fail to suckle effectively, despite the absence of gross or histologic abnormalities in brain (i.e. cortex and hippocampus), olfactory bulb, as well as facial or mouth tissues.Decreased motor neuron number:* newborn homozygotes display a significantly reduced number of motoneurons in the lumbar spinal cord, with no apparent change in the brachial or thoracic cord.* newborn homozygotes also exhibit a significant decrease in the number of motoneurons in the facial but not hypoglossal nucleus; sensory neurons of the dorsal root ganglia remain unaffected.Impaired hematopoiesis:* newborn homozygotes display reduced numbers of hemopoietic progenitor cells in the bone marrow and spleen* no differences in the numbers and lineage commitment of progenitor cells are observed in neonatal liver.",null,"129/Sv x C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2008-07-15",null,0,0,null,"WEHI #204 , 819","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5614,"B16A  (Nod Cg Tg)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7259,"HSA-Cre-ER T2","B6.129S2-Tg(ACTA1-cre/ERT2)97.16Mtz/NrosMarpApb","B6.129S2-Tg(ACTA1-cre/ERT2)97.16Mtz/Nros","Semi-dominant",{"$nulls":25},"transgene insertion 97.16, Daniel Metzger","human skeletal alpha-actin (ACTA1)",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MARP-2011-038-BC ","PC1-N54-10","No"]
[5289,"B6.TBM.Tg.1142-7.PAR1.KO","C57BL/6-F2r<tm1Ajc> Tg(H2-K<b>-TBM)",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No","human thrombomodulin","H2-K<b>","vascular endothelium and neutrophils",{"$nulls":9},"Unknown",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #182","true",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","N/A","N/A","No"]
[3562,null,"C57BL/6-Mnt<tm>",null,"Recessive","max binding protein","Mnt","Nil","Rox","MGI:109150",{"$nulls":3},"11",{"$nulls":15},"No",{"$nulls":12},"Postnatal lethality * homozygotes die within a few days of birthtumorigenesisAltered tumor susceptibility* MEFs infected with c-Myc and H-Ras viruses develop higher numbers of transformed foci* transformed cells capable of anchorage independent growthCellularAbnormal cell physiology * at early passages show improved growth rates and higher cell densities* enter more quickly into S phase* higher apoptosis levels in culture 24 hours after serum withdrawl* faster development of immortalized cell linesGrowth/SizeDecreased embryo size * apparent by E13.5",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01",null,0,0,null,"WEHI #1347","true",null,"Suzanne","Cory","Walter and Eliza Hall Institute of Medical Research","cory@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4935,"Cathepsin-S Knockout","C3H-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C3H","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-24",null,0,0,null,"WEHI #458","true",null,"Christopher","Parish","The Australian National University","christopher.parish@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7432,"Y20A","B6.129-Atp4b<tm1Ird> Tg(Atp4b*Y20A)/Ird/Apb",null,"Dominant","ATPase, H+/K+ exchanging, beta polypeptide","Atp4b","Nil","H+,K+-ATPase, H+/K+-ATPase beta, H,K-ATPase-Beta","MGI:88114","ATPase, H+/K+ exchanging, beta polypeptide; targeted mutation 1, Ian R van Driel","Atp4b<tm1Ird>","MGI:2158258","8",{"$nulls":16},"Mutated form of H+/K+ ATPase β subunit","CMV","moderate to high",{"$nulls":9},"Gastric Parietal cells of these mice lacked a tubulovesicular compartment, and the H/K ATPase was resident exclusively on the apical plasma membrane. Despite the inability of the H/K ATPase to be endocytosed, the gastric acid secretory response to histamine or an antagonist was very similar to that of wild-type mice,","normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">10",null,null,"No","2013-09-10","Cryopreserved sperm",50,0,null,null,"false",null,"Ian","van Driel","The University of Melbourne","i.vandriel@unimelb.edu.au",{"$nulls":3},"Ian","van Driel","i.vandriel@unimelb.edu.au","08091107","2013/042","No"]
[36,"Dopey ; ENU3strain:031","B6;NOD-Ddr2<m1Anu>/AnuApb","B6;NOD-Ddr2<m1Anu>/AnuApb","Recessive","discoidin domain receptor family, member 2","Ddr2",null,"Ntrkr3","MGI:1345277","mutation 1, The Australian National University","Ddr2<m1Anu>","MGI:5008734","1","ENSMUSG00000026674","ENSMUST00000170800","Ddr2-202",{"$nulls":7},"171932145","6",null,null,"TCTCTTCTCTCCTCTTCCCATGGCCTGAGCAGCATGACTGAAGGGCTAGGCCAGTTGACT","Yes",{"$nulls":12},"Dwarf, short face",null,"C57BL/6JSfdAnu x NOD/Lt.Cg-H2<k>","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm",47,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[1947,"C57BL/6-TLR-4<tm1> ; Teague","B6;129P2-Tlr4<tm1Aki>/AnuApb","B6;129P2-Tlr4<tm1Aki>","Recessive","toll-like receptor 4","Tlr4","Nil","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; targeted mutation 1, Shizuo Akira","Tlr4<tm1Aki>","MGI:1860885","4",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-01","Cryopreserved sperm",140,0,"ANU","081","false",null,"Simon","Phipps","The University of Newcastle","Simon.Phipps@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[5586,"3G",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4704,"NODβ2M-/- β2Mb homozygous 8.3TCRαβ","NOD.B6-B2m<tm1Jae> Tg(B2mb)1Rms Tg(TcraTcrbNY8.3)1Pesa/MarpApb",null,"Recessive","beta-2 microglobulin","B2m","Unknown","beta 2 microglobulin, beta2-m, Ly-m11","MGI:88127","targeted mutation 1, Rudolf Jaenisch","B2m<tm1Jae>","MGI:1927183","2",{"$nulls":15},"Yes","transgene insertion 1, Robyn M Slattery",{"$nulls":13},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Robyn","Slattery","Monash University","Robyn.Slattery@med.monash.edu.au",{"$nulls":3},"Robyn","Slattery","Robyn.Slattery@med.monash.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Pere Santamaria"]
[1761,"Caspase-9 knockout","C57BL/6-Casp<tm1Flv>/Wehi",null,"Recessive","caspase 9","Casp9","Nil","Caspase-9, ICE-LAP6, Mch6","MGI:1277950","targeted mutation 1, Richard A Flavell","Casp9<tm1Flv>","MGI:2158755","4",{"$nulls":15},"No",{"$nulls":12},"Perinatal lethality: normal mendelian ratio at E16.5 but fewer than 3% of the pups born are homozygotes.Abnormal neural tube closure: failure of neural tube closure in hindbrain region apparent by E10.5 and persists.Abnormal brain morphology.Abnormal brain development: enlargement of the proliferative zone in the forebrain and midbrain with resultant protrusion of brain mass.Abnormal embryonic neuroepithelial layer differentiation:* lacking pyknotic clusters* lamina terminalis of the forebrain is thicker with increased number and density of cells.Abnormal forebrain development.Abnormal telencephalon development: E16.5 expanded midbrain displaces telencephalic vesicles.Exencephaly: by E16.5 prominent exencephaly of the entire cranial tissues with enlarged and irregularly shaped protruding brain masses.Abnormal brain ventricle morphology: stenosis of the cerebral ventricles, lateral and third ventricles obstructed by E13.5.Abnormal lateral ventricle morphology.Abnormal third ventricle morphology.Abnormal telencephalon morphology: heterotopias and discontinuities of the proliferative ventricular zone lead to invagination and complete interruption of the telencephalic wall.Abnormal cerebral cortex morphology.Abnormal midbrain morphology.Decreased neuron apoptosis:* E13 olfactory epithelium has lower levels of olfactory receptor neuron apoptosis than normal.* absence of activated caspase 3 in the developing brain as assessed by immunohistochemistry with antibody CM1.* nearly 10 fold reduction in TUNEL-positive cells in E12.5 neuroepithelium.* fewer TUNEL-positive cells in the E16.5 spinal cord and E12.5 dorsal root ganglia although there is no change in TUNEL staining in E12.5 liver.Normal apoptosis in interdigital webbing retraction.Abnormal thymocyte apoptosis: thymocytes are delayed in apoptotic response to anti-CD3 + andi-CD28, etoposide, gamma irradiation, and dexamethasone, but have normal apoptotic response to Fas stimulation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10",null,null,"No","2007-08-02",null,0,0,null,"WEHI #317","true",null,"David","Vaux","Walter and Eliza Hall Institute of Medical Research","vaux@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4179,"APN7","B6;29-Ifrd1<Gt(AZ0065)Wtsi>/MIMR",null,"Recessive","interferon-related developmental regulator 1","Ifrd1","Unknown","Ifnl, PC4, Tis7","MGI:1316717","interferon-related developmental regulator 1; gene trap AZ0065, Wellcome Trust Sanger Institute","Ifrd1<Gt(AZ0065)Wtsi>","MGI:3857584","12",{"$nulls":15},"Yes",{"$nulls":12},"Unknown.  Note: Homozygous null mice display impaired muscle regeneration and myogenic differentiation and decreased body weight in older mice.","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1",null,"Chimera x C57BL/6","No","2008-12-18","Cryopreserved sperm",30,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","sue.chapman@monash.edu","N/A","N/A","No"]
[841,"OT2; OTII","C57BL/6-Tg(TcraTcrb)425Cbn",null,"Dominant",{"$nulls":25},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.T cells express T cell receptor specific for chicken ovalalbumin residues 323 - 339 in the context of H2-Ab1 (I-A<b>)Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous transgenic mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[7047,"βA Flox","B6.129S7-Inhba<tm3Zuk>/MarpApb",null,"Dominant","inhibin beta-A","Inhba",null,"activin","MGI:96570","inhibin beta-A; targeted mutation 3, Martin M Matzuk","Inhba<tm3Zuk>","MGI:3758877","13",{"$nulls":28},"Normal","Normal","C57BL/6 x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-08-13","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Mark","Hedger","Monash University","mark.hedger@monash.edu",{"$nulls":3},"Rosemary ","Genovese","Rosemary.genovese@monash.edu","MMCA 09/24","PC1-N27/09","No"]
[4602,null,"MRL/MpJ-Fas<lpr>/MarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"Premature death, decreased B cell number, decreased CD4 and CD8 -positive T cell number, decreased activated T cell number, increased double-negative T cell number, enlarged spleen and lymph nodes, abnormal leukocyte rolling - increased adhesion, development of anti-nuclear antibodies, glomerulonephritis. ",null,"MRL/MpJ","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm",115,0,"Monash",null,"false",null,"Michael","Hickey","Monash University","Michael.Hickey@med.monash.edu.au",{"$nulls":3},"Michael","Hickey","Michael.Hickey@med.monash.edu.au","N/A","N/A","No"]
[7260,"MLC-IGF/F08 (MLC=mIGF-1-8) ","B6(Cg)-Tg(Myl1-Igf1)1Nros/MarpApb","B6(Cg)-Tg(Myl1-Igf1)1Nros","Semi-dominant",{"$nulls":25},"transgene insertion 1, Naida Rosenthal","myosin light chain",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MARP-2011-038-BC ","PC1-N54-10","No"]
[1738,"VavP-BCL2-45","C57BL/6-Tg(Vav-BCL2)45Jad/Wehi",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","transgene insertion 45, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":10},"Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,null,"WEHI #56","true",null,"Jerry","Adams","Walter and Eliza Hall Institute of Medical Research","adams@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[847,"Traf2 floxed","C57BL/6-Traf2<tm1Rbr>",null,"Dominant","Tnf receptor-associated factor 2","Traf2","Normal",null,"MGI:101835","targeted mutation 1, Robert Brink","Traf2<tm1Rbr>","MGI:3511494","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[75,"Theodor","ENU4AT:011",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Low IgG2a response to B. pertussis",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2004-08-18","Cryopreserved sperm",30,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Heather","Domaschenz","heather.domaschenz@anu.edu.au","J.APF.21.08","N/A","No"]
[4601,null,"NOD.B6-Socs3<tm2Wsa>/WehiApb",null,"Dominant","suppressor of cytokine signaling 3","Socs3","Normal","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":15},"Yes",{"$nulls":12},"Normal. When crossed with Cre expressing strain allows deletion of Socs3 in tissue specific manner.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","7",null,"Socs3<tm2Wsa> x NOD","No","2009-03-13","Cryopreserved sperm",130,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[843,"SW{HEL}-H","C57BL/6-Igh<tm1Rbr>",null,"Dominant",{"$nulls":25},"immunoglobulin heavy chain complex; targeted mutation 1, Robert Brink",{"$nulls":11},"B cells express immunoglobulin Heavy chain that recognises hen egg lysozyme.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[4598,null,"B6.129-Apc<Min> Myb<tm1Ssp>",null,"Semi-dominant","adenomatosis polyposis coli","Apc","Nil","Min","MGI:88039","multiple intestinal neoplasia","Apc<Min>","MGI:1856318","18",{"$nulls":15},"Yes",{"$nulls":12},"For Myb<tm1Ssp> Homozygous null fetuses are severely anemic due to defects in fetal hepatic hematopoiesis.  Embryonic lethal at E15.5For Apc<min> Homozygotes are embryonic lethal.","For Apc<min> heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding.For Myb<tm1Ssp> are viable and fecund","C57BL/6 x 129","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Apc<min+/-> Myb<tm1Ssp +/-> x Apc<min+/-> Myb<tm1Ssp +/->","No","2009-03-13",null,0,0,null,null,"true",null,"Robert","Ramsay","Peter MacCallum Cancer Centre","rob.ramsay@petermac.org",{"$nulls":3},"Michael","Buchert",null,"N/A","N/A","No"]
[4598,null,"B6.129-Apc<Min> Myb<tm1Ssp>",null,"Semi-dominant","myeloblastosis oncogene","Myb","Unknown","c-myb","MGI:97249","targeted mutation 1, S Steven Potter","Myb<tm1Ssp>","MGI:2662859","10",{"$nulls":58},"Michael","Buchert",null,"N/A","N/A"]
[6426,"Blys2tg","B6.Cg-Tg(Tnfsf13b)1Fma/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Fabienne Mackay","human liver-specific alpha-1-antitrypsin promoter",{"$nulls":10},"Increased B cell number:*Splenic B cell numbers are about twice that of controls.      Increased transitional stage B cell number:        *Numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled.      Increased marginal zone B cell number:        *The number of splenic marginal zone B cells is increased by about 3-fold.Abnormal B cell activation:*B cells have a vigorous response to T cell independent antigens producing much higher levels of IgG1, IgG2a, IgG2b, IgG3, and IgA class immunoglobulins than controls.Abnormal spleen marginal zone morphology:*The size of the marginal zone is increasedAbnormal marginal zone B cell physiology:*Marginal zone B cells (MZB) mediate autoimmune disease in these transgenic mice as demonstrated by auto-antibody production when MZB are transferred into transgenic mice on a B-cell deficient background.*MZB from transgenic mice have higher integrin adhesion activity.Increased anti-double stranded DNA antibody level:*Anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation.*Titers of these auto-antibodies increase with.*Splenectomy at three weeks of age significantly reduces IgG auto-antibodies and partially reduces auto-antibodies in the other subclasses.Glomerulonephritis:*Kidneys of 10-month old mice have necrotic lesions.*Immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG.Proteinuria:*All 8-month old mice have proteinuria in their urine with most having 100-300 mg/dl.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","56","true",null,"Shane","Grey","Garvan Institute","s.grey@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[848,"Traf3 KO","C57BL/6-Traf3<tm1.1Rbr>",null,"Recessive","Tnf receptor-associated factor 3","Traf3","Unknown","CAP-1, CD40bp, CRAF1, LAP1","MGI:108041","targeted mutation 1.1, Robert Brink","Traf3<tm1.1Rbr>","MGI:3777325","12",{"$nulls":15},"Yes",{"$nulls":12},"Not analysed",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[173,null,"C57BL/6-Tau-GFP",null,"Dominant",{"$nulls":26},"CMV intermediate early enhancer coupled to the chicken beta actin promoter",{"$nulls":10},"Every cell expresses a tau-GFP fusion protein, enabling visualization of microtubules and long cell processes (including axons). Mice homozygous for the transgene do not survive.  ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[1712,"Rag2 gammaC","C57BL/6-IL2rg<tm1Cgn> Rag2<tm1Fwa>",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg","Nil","[g]c, CD132, common cytokine receptor gamma chain, common gamma chain, gamma C receptor, gamma(c), gc","MGI:96551","interleukin 2 receptor, gamma chain; targeted mutation 1, University of Cologne","Il2rg<tm1Cgn>","MGI:1861947","X",{"$nulls":15},"Yes",{"$nulls":12},"Severely immunocompromised throughout life.The common gamma (gc) KO mouse lacks functional receptors for many cytokines including IL-2, IL-4, IL-7, IL-9, and IL-15. As a consequence lymphocyte development is greatly compromised. The mouse lacks Natural Killer (NK) cells and produces only a small number of T and B cells. To eliminate the residual T and B cells this mouse was crossed to the recombinase activating gene 2 (Rag-2) deficient mouse. The double knock-out should now lack T cells, B cells, and NK cells. A preliminary analysis of this strain showed no detectable NK1.1+ cells, B220+ B cells or Thy1+ T cells in the spleen. A small number of the 1-3 million cells obtained were CD45 low and probably are cells in the macrophage/monocyte lineage. Functional tests, performed by Drs. Elias Hadaad and Pierre Henkart of NIH, for NK killing activity in the spleen, with or without poly I:C stimulation, were negative.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-26",null,0,0,null,"WEHI ID #20 ; St V #155","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":3},"Stephen","Nutt","nutt@wehi.edu.au","N/A","N/A","No"]
[1712,"Rag2 gammaC","C57BL/6-IL2rg<tm1Cgn> Rag2<tm1Fwa>",null,"Recessive","recombination activating gene 2","Rag2","Unknown","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2",{"$nulls":58},"Stephen","Nutt","nutt@wehi.edu.au","N/A","N/A"]
[185,null,"OMP-tau:GFP",null,"Recessive","olfactory marker protein","Omp","Nil",null,"MGI:97436","targeted mutation 3, Peter Mombaerts","Omp<tm3Mom>","MGI:3692201","7",{"$nulls":15},"Yes",{"$nulls":12},"All primary olfactory neurons express GFP",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Brian","Key","The University of Queensland","brian.key@uq.edu.au",{"$nulls":3},"Brian","Key","brian.key@uq.edu.au","N/A","N/A","No"]
[186,"P2-IRES-tauLacZ","B6.129-Olfr17<tm1Mom>",null,"Dominant","olfactory receptor 17","Olfr17","Unknown","GA_x6K02T2PBJ9-9470146-9471093, MOR263-5, P2","MGI:109148","targeted mutation 1, Peter Mombaerts","Olfr17<tm1Mom>","MGI:2179510","7",{"$nulls":15},"No",{"$nulls":12},"P2 odorant receptor neurons express LacZ",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Brian","Key","The University of Queensland","brian.key@uq.edu.au",{"$nulls":3},"Brian","Key","brian.key@uq.edu.au","N/A","N/A","No"]
[187,null,"VR1-IRES-tau:GFP",null,"Dominant",{"$nulls":37},"A subpopulation of vomeronasal neruons innervating the rostral accessory olfactory bulb express GFP",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Brian","Key","The University of Queensland","brian.key@uq.edu.au",{"$nulls":3},"Brian","Key","brian.key@uq.edu.au","N/A","N/A","No"]
[647,"AMY","Un-Tg(APPswe,PSEN1dE9)85Dbo",null,"Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","mouse prion promoter",{"$nulls":11},"Amyloidosis.Amyloid beta deposits.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25",null,0,0,null,null,"true",null,"Ray","Yates","Flinders University","Ray.Yates@flinders.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1787,"Bax / Bak knockout","129-Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice lacking bax display limited phenotypic abnormalities. Bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-) bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.      Those that survive are runted and grey.",null,"129/Sv","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #492","true",null,"David","Huang","Walter and Eliza Hall Institute of Medical Research","huang@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1787,"Bax / Bak knockout","129-Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","Bcl2-associated X protein","Bax","Unknown",null,"MGI:99702","targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7",{"$nulls":61},"N/A","N/A"]
[645,null,"IL-12 KO",null,"Dominant","not sure if alpha or beta",null,"Unknown",{"$nulls":5},"1",{"$nulls":15},"Yes",{"$nulls":15},"No","No","No","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25",null,0,0,null,null,"true",null,"Pam","Sykes","Flinders University","pam.sykes@flinders.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7345,"PTEN lox P locus/MMTV CRE","B6.129P2-Pten<tm2Mak> Tg(MMTV-Cre)4Mam/Apb",null,"Dominant","phosphatase and tensin homolog","Pten",null,null,"MGI:109583","phosphatase and tensin homolog; targeted mutation 2, Tak W Mak","Pten<tm2Mak>","MGI:2182005","19",{"$nulls":16},"transgene insertion 4, Lothar Hennighausen","mouse mammary tumor virus (MMTV) long terminal repeat",{"$nulls":10},"Neoplastic proliferation of prostate and skin tissues","Susceptible to tumour development","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-05-28","Cryopreserved sperm",45,0,null,null,"false",null,"Christopher","Hovens","The University of Melbourne","chovens@unimelb.edu.au",{"$nulls":3},"Chris ","Hovens","chovens@unimelb.edu.au","SABC","2008.04","No"]
[7666,"Depdc5-w","B6;C-Depdc5<m1Wehi>/AnuApb","B6.Cg;C-Depdc5<m1Wehi>/AnuApb","Recessive","DEP domain containing 5","Depdc5","Unknown",null,"MGI:2141101","DEP domain containing 5; mutation 1, Walter and Eliza Hall Institute","Depdc5<m1Wehi>","MGI:5648439","5","ENSMUSG00000021431","ENSMUST00000091641","Snrnp48-201","794","828","A to G","ENSMUSE00000117800","7","265","Aspartic acid to Glycine",{"$nulls":4},"CTGGCAGGAAGAGCAGGGGAGAGCAGGAGACGCTGCTGAGAAGAATGAAGAAAGGCGGTCA",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",null,"G3","Het x Het","No","2014-04-28","Cryopreserved sperm",72,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[175,"OVE550","FVB/N-Tg(Cryaa-Tgfbr2*)550/Apb",null,"Dominant",{"$nulls":25},"truncated TGFβ receptor II, kinase deficient","αA-crystallin, Cryaa",{"$nulls":10},"Nuclear cataract, characterised by rapid apoptosis and death of terminally differentiating lens fibres cells at E18.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17","Cryopreserved sperm",50,0,null,null,"false",null,"Robb","de Iongh","The University of Melbourne","r.deIongh@unimelb.edu.au",{"$nulls":3},"Robb","Iongh","r.deIongh@unimelb.edu.au","05068","2008/082","No"]
[202,"TGFbRIII floxed","Tgfbr3<flox>",null,"Recessive","transforming growth factor, beta receptor III","Tgfbr3","Normal","betaglycan, TBRIII","MGI:104637",{"$nulls":3},"5",{"$nulls":15},"Yes",{"$nulls":12},"Phenotypically normal. When crossed to Cre transgenics, will create knockout of TGFbRIII gene",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-20",null,0,0,null,null,"true",null,"Kaye","Stenvers","MIMR-PHI Institute of Medical Research","kaye.Stenvers@princehenrys.org",{"$nulls":3},"Kaye","Stenvers","kaye.Stenvers@princehenrys.org","N/A","N/A","No"]
[7084,"MommeD33","FVB/NJ-MommeD33 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D33","Su-var39h","Unknown",null,null,"modifier of murine metastable epialleles, D33",null,null,"X",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"homo viable","Normal","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"MommeD33<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-14","Cryopreserved sperm",30,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[5214,"mIMPα4FL (low level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)low",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","low level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-08-30","Cryopreserved sperm",40,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[4099,null,"KRN:187",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Hypo response post arthritogenic serum transfer",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"1",null,"No","2008-12-04","Cryopreserved sperm",75,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[1812,"C57BL/6. Socs2 KO","C57BL/6-Socs2<tm1Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 2","Socs2","Nil","CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2","MGI:1201787","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs2<tm1Wehi>","MGI:1934557","10",{"$nulls":15},"Yes",{"$nulls":12},"SOCS-2(-/-) mice grew significantly larger than their wild-type littermates. Increased body weight became evident after weaning and was associated with significantly increased long bone lengths and the proportionate enlargement of most organs. Characteristics of deregulated growth hormone and insulin-like growth factor-I (IGF-I) signalling, including decreased production of major urinary protein, increased local IGF-I production, and collagen accumulation in the dermis, were observed in SOCS-2-deficient mice, indicating that SOCS-2 may have an essential negative regulatory role in the growth hormone/IGF-I pathway. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #462, 856","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5552,"Dravid","C57BL/6-Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":16},"transgene insertion 1100, Michael J Bevan",null,"High - 49 Copies",{"$nulls":9},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-10","Cryopreserved sperm",45,0,"ANU","011","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4079,null,"ENU6PH:058",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"6",null,"No","2008-12-04","Cryopreserved sperm",15,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[7344,"PBCre","B6;DBA2-Tg(Pbsn-cre)4Prb/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 4, Pradip Roy-Burman","rat Pbsn",{"$nulls":11}," Cre recombinase is expressed postnatally in prostatic epithelium with the highest level of expression in the lateral lobe of the prostate gland. A very low level of transgene expression was detected in the seminal vesicles, testes, and ovaries.","(C57BL/6 x DBA/2)F1","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-05-28","Cryopreserved sperm",54,0,null,null,"false",null,"Christopher","Hovens","The University of Melbourne","chovens@unimelb.edu.au",{"$nulls":6},"SABC","2008.04","No"]
[706,null,"NOD.Cg-Igh-6<tm1Cgn> Tg(IghelMD4)4Ccg/Dvs",null,"Recessive","immunoglobulin heavy chain 6 (heavy chain of IgM)","Igh-6","Nil","BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","targeted mutation 1, University of Cologne","Igh-6<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"Yes",{"$nulls":12},"Do not express endogenous IgM, viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.All B lymphocytes in NOD.Igh-6 deficient transgenic mice express Ig molecules specific for HEL.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-02",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[1785,"Cathepsin D knockout","Un-Ctsd<tm1Cptr>",null,"Recessive","cathepsin D","Ctsd","Nil","CatD, CD","MGI:88562","targeted mutation 1, Cristoph Peters","Ctsd<tm1Cptr>","MGI:2182078","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null mutation die in a state of anorexia at ~P26, displaying severe atrophy of the intestinal mucosa, and massive destruction of the thymus and spleen with loss of T and B cells; near the terminal stage, affected mice have seizures, display retinal atrophy, and become blind.",null,null,"Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #471","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1816,"Oct2 deltaC","B6.129-Pou2f2<tm1Lmc>/Wehi",null,"Recessive","POU domain, class 2, transcription factor 2","Pou2f2","Normal","Oct-2, Oct2a, Oct2b, Otf-2, Otf2","MGI:101897","POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran","Pou2f2<tm1Lmc>","MGI:3037094","7",{"$nulls":15},"No",{"$nulls":12},"Neonatal lethality: homozygous mice die shortly after birth.Decreased B cell number: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced.Decreased B-1 B cell number: these mice also lack peritoneal B-1 cells.Arrested B cell differentiation: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling.Decreased immunoglobulin level: in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #957","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5593,"A2Kb ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5594,"Actm0va (actin0va)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[703,"NR4MD4","NOD.NOR-(D4Mit31-D4Mit310) Tg(IghelMD4)4Ccg",null,"Dominant","insulin dependent diabetes susceptibility 9","Idd9","Unknown","Idd-9","MGI:96411","NOR/LtJ","Idd9<NOR/LtJ>","MGI:3582457","4",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":11},"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-02",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[1730,"B6 Bclw -/- 228","B6.129-Bcl2l2<tm1Sco>/Wehi",null,"Recessive","Bcl2-like 2","Bcl2l2","Nil","Bcl-w, bclw, Gtrgal2, Gtrosa41","MGI:108052","targeted mutation 1, Suzanne Cory","Bcl2l2<tm1Sco>","MGI:2158430","14",{"$nulls":15},"Yes",{"$nulls":12},"Most tissues exhibited typical histology, and hematopoiesis was unaffected, presumably due to redundant function with other pro-survival family members. Although female reproductive function was normal, the males were infertile. The testes developed normally, and the initial, prepubertal wave of spermatogenesis was largely unaffected. The seminiferous tubules of adult males, however, were disorganized, contained numerous apoptotic cells, and produced no mature sperm. Both Sertoli cells and germ cells of all types were reduced in number, the most mature germ cells being the most severely depleted.",null,null,"Yes","Yes","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,null,"WEHI #45","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[774,"NIDM5MD4ML5","NOD-Idd5<C57BL/10> Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg",null,"Dominant","insulin dependent diabetes susceptibility 5","Idd5<C57BL/10>","Nil","Idd-5","MGI:2389023","C57BL/10","Idd5<C57BL/10>","MGI:2389023","1",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":12},"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-18",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 5, Christopher C Goodnow","mouse metallothionein I"]
[7609,"Pax7","B6.D2-Tg(Pax7-EGFP)#Tajb/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion, Shahragim Tajbakhsh","Pax7","muscle",{"$nulls":9},"Expression of nGFP in muscle satellite cells.","Expression of nGFP in muscle satellite cells.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-02-28",null,0,0,"ABR - Moss Vale","3135","true",null,"Edna","Hardeman","The University of Sydney","ehardeman@cmri.usyd.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1824,null,"B6.129-H2-Ab1<tm1Gru>",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Nil","A beta, Abeta, H-2Ab, H2-Ab, I-Ab, I-Abeta, Ia-2, Ia2, IAb, Rmcs1","MGI:103070","targeted mutation 1, Michael J Grusby","H2-Ab1<tm1Gru>","MGI:2158420","17",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.Decreased CD4-positive T cell number.Increased CD8-positive T cell number.Abnormal level of surface class II molecules: MHC II complex is not expressed on the surface of cells.Decreased IgG1 level.Decreased IgM level.Abnormal response to transplant:* skin grafts from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen) are indistinguishable from wild-type donor skin grafts for the first 40 days.* rejection starts occurring after 40 days with 25% of the transgenic grafts being completely lost after 115 days.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"The colony is maintained by brother x sister mating of homozygotes.","No","2007-08-06",null,0,0,null,"WEHI #1048","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[781,"VAMP2 KO","C57BL/6-Vamp2<->",null,"Recessive","vesicle-associated membrane protein 2","Vamp2","Nil","Syb-2, Syb2, synaptobrevin II","MGI:1313277",{"$nulls":3},"11",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"David","James","d.james@garvan.org.au","N/A","N/A","No"]
[776,null,"B6.Cg-Tg(Fabp4-cre)1Rev/J",null,"Dominant",{"$nulls":25},"transgene insertion 1, Ronald M Evans","fatty acid binding protein 4, adipocyte, mouse (Fabp4)",{"$nulls":10},"Transgene expressed in brown and white adipose tissue.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-18",null,0,0,null,null,"true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"David","James","d.james@garvan.org.au","N/A","N/A","No"]
[5247,"ENU11B6 45a","ENU11B6:045a",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to infection with TB",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good","0","5","Sib x sib","No","2010-10-19","Cryopreserved sperm",20,0,"ANU",null,"true",null,"Bernadette","Saunders","Centenary Institute","b.saunders@centenary.usyd.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[8574,"MMTV-Neu/FVB/N","FVB-Tg(MMTVneu)/WehiVccc",null,"Dominant",{"$nulls":25},"transgene insertion 202, William Muller","MMTV (mouse mammary tumor virus)",{"$nulls":10},"These mice develop tumours at approximately 6 - 8 months.   Mammary adenocarcinoma.Metastatic potential.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27",null,0,87,null,null,"false",null,"Patrick","Humbert","La Trobe Institute of Medical Science","P.Humbert@latrobe.edu.au",{"$nulls":3},"Samantha","McIntosh","S.McIntosh@latrobe.edu.au",null,null,"No"]
[4086,null,"ENU8PH:025 , Cletus",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Alopecia (Hair loss).",null,"C57BL/6 x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"3",null,"No","2008-12-04","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[4932,"Aire knockout 384","BALB/c-Aire<tm1Scot>/Wehi",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Unknown",null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. An increase in the number of activated T cells was evident, and autoantibodies against several organs were detected. At the histological level, lymphocytic infiltration of several organs indicated the development of autoimmunity, although symptoms were mild.Male infertility.",null,"BALB/c","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-11-19",null,0,0,null,"WEHI #79","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hamish.scott@imvs.sa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[786,"PY1 KO","B6.129-Npy1r<tm1.1Wpg>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Nil","Npyr, Y1-R","MGI:104963","targeted mutation 1.1, William P Gray","Npy1r<tm1.1Wpg>","MGI:3053796","8",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.Increased litter size:* average litter size is 7.64 +/- 0.51 compared to 4.86 +/- 0.32 in wild-type mice.Decreased B cell number: all B cell subsets reducedDecreased transitional stage B cell number: type 1 and type 2 cells both reduced.Decreased mature B cell number.Abnormal T cell number.Decreased CD8-positive T cell number: slightly reduced in the spleen.Increased single-positive T cell number:Increased CD4-positive T cell number: significantly increased in the lymph nodes.Increased CD8-positive T cell number: significantly increased in the lymph nodes.Abnormal immune system organ morphology.Abnormal spleen morphology.Decreased marginal zone B cell number.Abnormal splenic cell ratio: reduced B cell numbers among splenocytes.Small spleen.Abnormal lymph node cell ratio: reduced numbers of B cells.Abnormal immune system physiology.Abnormal immune cell physiology.Abnormal T cell activation: hyper responsive to activation.Abnormal antigen presenting cell physiology: antigen presentation defective as tested by mixed lymphocyte response tests.Abnormal immunoglobulin level.Decreased IgG2a level: both baseline levels and levels in response to antigen are reduced.Increased immunoglobulin level: in response to antigenIncreased IgA level.Increased IgG2b level.Increased IgM level.Abnormal macrophage physiology: levels of Il12 released are reduced.* levels of TNF released are reduced.Abnormal T-helper 1 physiology: impaired* protected against Th1 cell mediated inflammatory conditions such as those resulting from sodium dextran sulfate treatmentAbnormal inflammatory response.Decreased circulating interleukin-12 level: decreased levels released by macrophage.Decreased circulating tumor necrosis factor level: decreased levels released by macrophage.Decreased interferon-gamma secretion: reduced productionDecreased susceptibility to type IV hypersensitivity reaction:* swelling reduced to 55% that of controls* reduced proliferation of lymph node cells* reduced production of IFN-gammaIncreased aggression towards mice:* territorial aggression but not spontaneous aggression is increased in homozygous mutants* injection of an Htr1a agonist reduces aggressive behavior in a dose-dependent mannerHyperactivity: homozygous males display increased movement in an open field test.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[787,"Y2 KO","B6.129-Npy2r<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Nil",null,"MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[3416,"RIP-OVA<hi>","C57BL/6-Tg(Ins2-OVA)59Wehi/Wehi",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 59, Walter and Eliza Hall Institute of Medical ResearchTg(Ins2-OVA)59Wehi","rat insulin 2","High - 49 Copies",{"$nulls":9},"Mice bearing this transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14",null,0,0,null,"WEHI #133","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3426,"anti-Hy transgenic strain","C57BL/6-Tg(TcraH-Y,TcrbH-Y)71Vbo",null,"Dominant",{"$nulls":25},"transgene insertion 71, Harald von Boehmer",{"$nulls":11},"Cells expressing the H-Y antigen were frequent in female but not male transgenic offspring, despite the fact that peripheral T cells in animals of both sexes expressed both transgenes, T cells in male (but not female) mice had an abnormal CD4/CD8 phenotpye: over 90% of T cells in male transgenic mice were CD4-8- or expressed only low levels of CD8 molecules and the numbers of CD4+8- T cells were very small.  This was due to deletion of autospecific thymocytes expressing high levels of CD8 molecules predominantly CD4+8+.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15",null,0,0,null,"WEHI #247","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[790,"Y4f","B6.129-Ppyr1<tm1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Normal","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1, Herbert Herzog","Ppyr<1tm1Hhz>","MGI:2183928","14",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[791,"Y1f","B6.129-Npy1r<tm1Wpg>",null,"Dominant","neuropeptide Y receptor Y1","Npy1r","Normal","Npyr, Y1-R","MGI:104963","targeted mutation 1, William P Gray","Npy1r<tm1Wpg>","MGI:3053795","8",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[807,"NPY KO x DYN KO","B6.129-Npy<tm1(cre)Tkar> Pdyn<tm1(cre)Czer>",null,"Recessive","neuropeptide Y","Npy","Nil",null,"MGI:97374","targeted mutation 1, Tim Karl","Npy<tm1(cre)Tkar>","MGI:3811718","6",{"$nulls":15},"Yes","Cre recombinase",{"$nulls":11},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[807,"NPY KO x DYN KO","B6.129-Npy<tm1(cre)Tkar> Pdyn<tm1(cre)Czer>",null,"Recessive","prodynorphin","Pdyn","Nil","Dyn","MGI:97535","targeted mutation 1, Christoph Schwarzer","Pdyn<tm1(cre)Czer>","MGI:3715202","2",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[7121,"Id3Fva∆","FVB/N(Cg)-Id3<tm1Cmu>/AusbApb",null,"Recessive","inhibitor of DNA binding 3","Id3","Nil","bHLHb25, HLH462, Idb3","MGI:96398","inhibitor of DNA binding 3; targeted mutation 1, Cornelis Murre","Id3<tm1Cmu>","MGI:3046425","4",{"$nulls":28},"Id3 nulls do not breed.Although ID3 deficiency (Id3(-/-) mice) had no noticeable impact on epididymal histology, the targeted mutation adversely affected sperm motility parameters. Moreover, principal component analysis of microarray data indicated that the gene expression signatures for tissues obtained from Id3(-/-) mice and their genotypic controls were distinct from each other in each epididymal region. The predominant effect of the Id3 null mutation was in the cauda region where the expression of many transcription factors, including Hoxb8 and Bclaf1, was markedly affected.Abnormal T cell differentiation: * the total number of thymocytes is unchanged however the percent and total number of CD4 single positive cells is significantly decreased and the percent and total number of CD8 single positive cells is slightly decreased * after 5 generations of backcrossing onto a C57BL/6J background slightly increased compared to wild-typeAbnormal double-positive T cell morphology: a small but consistent increase in CD5 expression is seen compared to wild-type littermates","None","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","6",null,"Heterozygous pairs","No","2012-10-31","Cryopreserved sperm",50,0,"ABR - Moss Vale","2266","false",null,"Alex","Swarbrick","Garvan Institute","a.swarbrick@garvan.org.au",{"$nulls":3},"Andrea","McFarland","a.mcfarland@garvan.org.au","10/04","3001-2007","No"]
[7668,"ASCIZ CD23 Bcl6","B6.Cg-Atmin<tm1.2Jhh> Ighm<tm1(Bcl6)Rdf> Tg(Fcer2a-cre)5Mbu/SviApb",null,"Dominant","ATM interactor","Atmin",null,null,"MGI:2682328","ATM interactor; targeted mutation 1.2, Jorg Heierhorst","Atmin<tm1.2Jhh>","MGI:5463937","8",{"$nulls":16},"transgene insertion 5, Meinrad Busslinger","Fcer2a  ",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","more than 10",null,null,"No","2014-04-30","Cryopreserved sperm",50,0,"St V",null,"true",null,"Jorg","Heierhorst","St Vincent's Institute","jheierhorst@svi.edu.au",{"$nulls":3},"David","Wong","dwong@svi.edu.au","0035/11","69","No"]
[7668,"ASCIZ CD23 Bcl6","B6.Cg-Atmin<tm1.2Jhh> Ighm<tm1(Bcl6)Rdf> Tg(Fcer2a-cre)5Mbu/SviApb",null,"Dominant","immunoglobulin heavy constant mu","Ighm",null,"BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT","MGI:96448","immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera","Ighm<tm1(Bcl6)Rdf>","MGI:3581517","12",{"$nulls":58},"David","Wong","dwong@svi.edu.au","0035/11","69"]
[3467,"Asb1 KO","C57BL/6-Asb1<tm1Wehi>/Wehi",null,"Recessive","ankyrin repeat and SOCS box-containing 1","Asb1","Nil","1700029O08Rik, 1700054C17Rik, mKIAA1146","MGI:1929735","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Asb1<tm1Wehi>","MGI:2178847","1",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutation of this gene results in spleen hypocellularity, decreased spermatogenesis, and thickening of the epithelial layer of the skin in male animals.Abnormal testis morphology:* in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes.* however, this abnormal testicular morphology has no impact on male fertility.Abnormal spermatogenesis: mutant testes frequently show less complete filling of the seminiferous tubules, suggesting reduced spermatogenesis.Hematopoietic system phenotype:* homozygotes show normal hemopoiesis, both at steady state and in response to several forms of hematopoietic stress* also, mutants exhibit no abnormalities of mature blood cells or their progenitors.Small spleen: homozygotes show normal splenic architecture but a mild reduction in spleen size.Spleen hypoplasia: reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset.Thickened epidermis:*56% of male homozygotes display thickening of the epithelial layer of skin, either in discrete patches or in a generalized distribution; only 14% of control C57BL/6 male mice exhibit epithelial thickening.* epithelial thickening is associated with squamous differentiation and some keratin formation; however, mutants show no consistent infiltration of cells in the underlying dermis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #464","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8573,"UBC-Cre/ERT2 Tg x FVB/N ; iCre","FVB/N.Cg-Tg(UBC-cre/ERT2)1Ejb/VcccApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Eric J Brown","human ubiquitin C (UBC) promoter",{"$nulls":11},"Mice display tamoxifen-inducible Cre activity in all tissue types. ","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27",null,0,30,"ANU",null,"false",null,"Patrick","Humbert","La Trobe Institute of Medical Science","P.Humbert@latrobe.edu.au",{"$nulls":3},"Samantha","McIntosh","S.McIntosh@latrobe.edu.au",null,null,"No"]
[1750,"Lck-Cre","B6.129-Tg(Lck-cre)157Jxm/WehiAnuApb",null,"Dominant",{"$nulls":25},"targeted mutation I57, Jamey Marth; transgene insertion I57, Jamey Marth","mouse proximal Lck promoter","active in thymocytes and splenocytes",{"$nulls":9},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10","sib x sib","No","2007-08-02","Cryopreserved sperm",82,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[812,"Y1Y5 KO","B6.129-Npy1r<tm1> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Unknown",null,"MGI:104963",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[812,"Y1Y5 KO","B6.129-Npy1r<tm1> Npy5r<tm1>",null,"Recessive","neuropeptide Y receptor Y5","Npy5r","Unknown","Y5R","MGI:108082",{"$nulls":3},"8",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y1","Npy1r","Nil","Npyr, Y1-R","MGI:104963","targeted mutation 1.1, William P Gray","Npy1r<tm1.1Wpg>","MGI:3053796","8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","neuropeptide Y receptor Y2","Npy2r","Unknown","NPY-Y2 receptor","MGI:108418","targeted mutation 1.1, Herbert Herzog","Npy2r<tm1.1Hhz>","MGI:2447398","3",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[813,"Y1Y2Y4 KO","B6.129-Npy1r<tm1.1Wpg> Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Nil","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[1751,"SOCS<lox>","B6.129-Socs1<tm3Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Normal","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","suppressor of cytokine signaling 1; targeted mutation 3, Walter and Eliza Hall Institute of Medical Research","Socs1<tm3Wehi>","MGI:2656917","16",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,null,"true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4952,"APN 15","B6.129-Slc2a3<Gt(XG611)Byg>/MIMR",null,"Recessive","solute carrier family 2 (facilitated glucose transporter), member 3","Slc2a3","Reduced","Glut-3, Glut3","MGI:95757","solute carrier family 2 (facilitated glucose transporter), member 3; gene trap XG611, BayGenomics","Slc2a3<Gt(XG611)Byg>","MGI:3822325","6",{"$nulls":29},"Nervous system phenotype:* no paroxysmal EEG activity* no epileptic seizuresAbnormal brain wave pattern: absolute EEG power densities show a slight but significant elevation.Decreased prepulse inhibition:* significant reduction in inhibition by a low intensity prepulse* inhibition due to a high intensity prepulse is normalBehavior/neurological phenotype:* performance normal in rotarod, open field, and shuttle box tests.* normal performance in a Morris water maze.* generally normal responses in anxiety related tests although some trends are noted.Increased anxiety-related response:* preference for closed compartment in elevated maze.* increased tendency to stay in illuminated areas in light/dark avoidance tests.Increased startle reflex: increased startle response.","C57BL/6 x 129","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2009-12-14","Cryopreserved sperm",81,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","sue.chapman@monash.edu","N/A","N/A","No"]
[1777,"B6.Bim Knockout clone 339 del","C57BL/6-Bcl2l11<tm1.1Ast>/Wehi",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Reduced","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"No",{"$nulls":12},"Increased numbers of lymphoid and myeloid cells. Spleen and lymph modes are 2-3-fold bigger than in wt. Sternum is sticking out.  Bim-/- females are bad mothers and should not be used for breeding unless necessary.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #422","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4438,"APN14","B6.129-Kdm1a<Gt(XP0207)Wtsi>/MIMR",null,"Recessive","lysine (K)-specific demethylase 1A","Kdm1a","Unknown","Aof2, Kdm1, LSD1, mKIAA0601","MGI:1196256","lysine (K)-specific demethylase 1A; gene trap XP0207, Wellcome Trust Sanger Institute","Kdm1a<Gt(XP0207)Wtsi>","MGI:3858605","4",{"$nulls":15},"No",{"$nulls":12},"Unknown for genetrap. Germline deletion of Aof2 causes early embryonic lethality (E7.5) probably due to defects in pituitary development and hormone production.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","1",null,null,"No","2009-02-17","Cryopreserved sperm",40,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","deborah.bianco@monash.edu","N/A","N/A","No"]
[7206,"classII-mOVA","C57BL/6-Tg(H2-Ab1-TFRC/OVA)3Cbn/Apb","C57BL/6-Tg(H2-Ab1-TFRC/OVA)3Cbn","Dominant",{"$nulls":25},"ovalbumin residues 139-385 fused to transferrin receptor membrane domain","MHC class II","moderate",{"$nulls":9},"NormalClass II mOVA mice express a membrane-bound form of ovalbumin (transferrin receptor membrane domain and OVA residues 139-385) under the control of the MHC class II promoter. OVA expression is directed to the membranes of cells that express MHC class II, such as B cells, macrophages and dendritic cells.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-11-09","Cryopreserved sperm",45,0,null,null,"false",null,"William","Heath","The University of Melbourne","wrheath@unimelb.edu.au",{"$nulls":3},"Gayle","Davey","daveyg@unimelb.edu.au","1112326","2011-032","No"]
[3477,"CBA.Rip-H2-Kb (lineage 50-1)","CBA-Tg(Ins2-H2-K<b>)/Wehi",null,"Dominant",{"$nulls":25},"H-2Kb heavy chain","rat insulin 2","In beta cells",{"$nulls":9},"Spontaneous, non-immune diabetes by 4-6 weeks of age. Diabetes is generally more severe in males (mean=23.0, sd=4.0 mmol/l at 6 weeks) compared to females (mean=16.8, sd=2.2 at 6weeks). Also appears to be more severe in homozygous compared to heterozygous mice although no formal analysis of the latter has been performed. Diabetes is stable and sufficiently mild that most heterozygous mice can be maintained to 40 weeks of age without parenteral insulin.","Diabetes is stable and sufficiently mild that most heterozygous mice can be maintained to 40 weeks of age without parenteral insulin.","CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",null,null,"Maintained as heterozygous line (CBA +/+ female x 50-1/CBA T/+ male)","No","2008-07-22",null,0,0,null,"WEHI #553","true",null,"Andrew","Lew","Walter and Eliza Hall Institute of Medical Research","lew@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[2744,"SXR","B6.CBA-Tg(Sox3)1Pqt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Paul Q Thomas","Sox3 promoter","2 copies; High with aberrant expression in gonads and CNS",{"$nulls":9},"Transgenic line only maintained as hemizygous. ","High Sox3 expression with aberrant expression in gonads and CNS. Heterozygous females will develop phenotypically as males in approximately 80% of cases. These animals also have occasional dwarfism as well as a tendency to develop hydrocephalus due to CNS abnormalities. Sex-reversed XX tg/+ males are sterile","CBA x C57BL/6","No","No","Yes","No","No","Yes","No","Good",null,null,"Tg/+ Male mated to a wildtype female","No","2008-02-10","Cryopreserved sperm",120,0,null,null,"false",null,"Paul","Thomas","The University of Adelaide","paul.thomas@adelaide.edu.au",{"$nulls":3},"Paul","Thomas","paul.thomas@adelaide.edu.au","N/A","N/A","No"]
[3553,null,"C57BL/6.129-Mpl<tm1Wsa>",null,"Recessive","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, thrombopoietin receptor, TPO-R","MGI:97076","targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.  Decreased hematopoietic stem cell number - in clonal culture of bone marrow, total progenotor cell number was 38%- 44% of wildtype.  Neutrophil-CFC, neutrophil-macrophage-CFC and pure erythroid-CFC were present at approximately 50% of normal levels.  Abnormal megakaryocyte progenitor cell morphology -mice are deficient in megakaryocyte progenitor cellsDecreased platelet cell number - mice had only 6% the number platelets detected in controlsAbsent megakaryocytes - mutant mice displayed a loss of megakaryocytes in the spleen and bone marrow",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31",null,0,0,null,"WEHI #1217","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6743,"KIf3LoxP","Klf3-LoxP conditional/Ausb",null,"Recessive",null,"Klf3",{"$nulls":6},"Unknown",{"$nulls":28},"None",null,"BL6/129SV/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2806","true",null,"Richard","Pearson","The University of New South Wales","richard.pearson@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4110,null,"KRN:153",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",30,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[3595,null,"C57BL/6.129-Rag1<tm1Mom> Ly5.1",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.   Mice homozygous for the Rag1tm1Mom mutation produce no mature T cells or B cells. Their phenotype can be described as a \"non-leaky\" severe combined immune deficiency (Prkdcscid/Prkdcscid) (Prkdcscid mice produce some B cells and IgM). They have no CD3+ or T cell receptor (TCR) alpha-beta positive cells. The thymus of the mutant mice contains 15 to 130 times fewer cells than heterozygous or wildtype siblings. The thymocytes are CD8-CD4- and most are IL2 receptor positive. Neither the spleen nor bone marrow contain any IgM or IgD staining cells, indicating an absence of mature B cells. These and other data suggest that B cell and T cell development has been arrested at an early stage. Macroscopically, the mutants are indistinguishable from heterozygotes or normal wildtype siblings. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06",null,0,0,null,"WEHI #1940","true",null,"Catheryn","O'Brien","Walter and Eliza Hall Institute of Medical Research","Obrien@wahi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7230,"KRasG12D","B6.129-Kras<tm4Tyj>/JMarpApb",null,"Dominant","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","Kras","Normal","Ki-ras, K-ras, Kras2, Kras-2","MGI:96680","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks","Kras<tm4Tyj>","MGI:2429948","6",{"$nulls":28},"Normal until mice crossed with Cre expressing strain.Expression of adenovirus controlled Cre recombinase results in lung tun our development.Treatment with adenoviral Cre injection results in ovarian endometriosis like lesions.Abnormal peritoneum morphology: * 47% of mutants develop peritoneal endometriosis following ovarian intrabursal injection of an adenovirus expressing Cre * however, mice injected with adenovirus expressing Cre directly into the peritoneum do not develop peritoneal endometriosis.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-22","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Duangporn","Jamsai","Monash University","duangporn.jamsai@monash.edu",{"$nulls":3},"Duangporn","Jamsai","duangporn.jamsai@monash.edu","N/A","N/A","No"]
[7358,"ENU25 26 TNPO3","C57BL/6NCrlAnu-Tnpo3<m1Anu>/AnuApb","C57BL/6NCrlAnu-Tnpo3<m1Anu>/AnuApb","Recessive","transportin 3","TNPO3","Unknown","5730544L10Rik, C430013M08Rik, D6Ertd313e ","MGI:1196412","transport in 3; mutation 1, The Australian National University","Tnpo3<m1Anu>","MGI:5563403","6","ENSMUSG00000012535","ENSMUST00000012679","Tnpo3-001","1508","1910","A to T","ENSMUSE00001238723","12","503","Leucine to STOP",{"$nulls":4},"CCGGAATCCCCAGTTCCTGGACCCTGTATTGGGCTATTTGATGAAAGGCCTGTGTGAAAAG",{"$nulls":13},"Homozygous mutation appears lethal","Heterozygous mice appear healthy and normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Good",null,"Generation 4","HET x HET","No","2013-06-20","Cryopreserved sperm",36,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"No"]
[7237,"K5rTA-TSLP 0419","C57BL/6-Tg(K5-rTA)04Cbn Tg(TetO-TSLP)19Cbn/Apb",null,"Dominant",{"$nulls":25},"tetracycline-regulated transcriptional transactivator","bovine keratin-5",{"$nulls":10},"In these mice following oral doxycyline treatment, rTA expresssion induced in the skin activates the TetO promoter driving TSLP expression in the skin.In the absence of doxycyline treatment the mice are normal for lifespan and breeding.","As for homozygous mice.","C57Bl/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Tg/+ +/+ x +/+ Tg/+","No","2012-11-28","Cryopreserved sperm",50,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","1112121","2011-032","No"]
[{"$nulls":30},"thymic stromal lymphopoietin","CMV minimal promoter and 7 TetO sequences"]
[3522,"NOD.B6-Idd14","NOD.B6-Idd14<C57BL/6>",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 14","Idd14","MGI:99416","13",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28",null,0,0,null,"WEHI #901","true",null,"Tom","Brodnicki","Walter and Eliza Hall Institute of Medical Research","brodnicki@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1755,"Bmf Del/376","C57BL/6-Bmf<tm1.1Anvi>/Wehi",null,"Recessive","Bcl2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1.1, Andreas Villunger","Bmf<tm1.1Anvi>","MGI:3778610","2",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal spleen morphology.Enlarged spleen: significantly enlarged at 12 months.Spleen hyperplasia: increased by more than 50%.Abnormal immune system cell morphology.Abnormal B cell morphology: increased immature B cell number.Increased pre-B cell number: significantly elevated numbers in bone marrow while pro-B cell numbers are normal.Increased transitional stage B cell number:* both T1 and T2 transitional B cells are elevated* increased T1 transitional B cells in inguinal lymph nodesIncreased mature B cell number: * mature B cell numbers are elevated.* increased numbers in inguinal lymph nodes* increased numbers in peripheral bloodIncreased follicular B cell number: elevated while marginal B cell numbers are normal.Decreased B cell apoptosis: highly resistant to apoptosis caused by dexamethasone.Increased immunoglobulin level: total serum levels elevated at 8-10 weeks but not at 1 year of age.Decreased T cell apoptosis:* double positive T cells with increased resistance to the apoptotic effects of dexamethasone* thymocytes and double positive T cells resistant to the apoptotic effects of suberoylanilide hydroxamic acidTumorigenesis: no B cell neoplasia through 18 months of ageThymic lymphoma: increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #310","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1361,"IL21 KO","B6.129-IL21<tm1Lex>",null,"Recessive","interleukin 21","Il21","Nil",null,"MGI:1890474","targeted mutation 1, Lexicon Genetics","Il21<tm1Lex>","MGI:3528994","3",{"$nulls":15},"No",{"$nulls":12},"Decreased germinal center B cell number:* the percentage of GC B cells that make up the total B cell population in the spleen of immunized mice is reduced by two-thirdsAbnormal CD4-positive T cell morphology:* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Abnormal spleen germinal center morphology:* the number of actively proliferating T cells found within GC is reduced 3- to 4- fold.* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Decreased spleen germinal center number:* there is a paucity of GC in the spleen of mice after immunization with sheep red blood cells (SRBC).Decreased CD4-positive T cell number:* Il-17+ CD4+ cells are absent from lamina propria and spleen in mutants.Abnormal T cell differentiation:* when naive TH cells are subjected to TH17 differentiation, a deficit in generation of Il-17-producing cells is observed with an increased number of Foxp3+ cells compared to wild-type.* one week after immunization with MOG peptide in CFA, restimulation of spleen cells with TPA or MOG peptide results in production of almost no Il-17 producing cells, showing impaired TH17 differentiation.Abnormal gamma-delta T cell morphology:*lamina propria and splenic TCRgd+ T cells show <10-fold decrease in Il-17-expressing cells compared to wild-type cells.Abnormal interleukin level:* CNS-infiltrating and splenic CD4+ T cells produce interferon gamma, in contrast to CD4+ T cells from controls which produce predominantly Il-17.",null,"129/SvEvBrd x C57BL6/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22",null,0,0,null,null,"true",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au",{"$nulls":3},"Cecile","King","c.king@garvan.org.au","N/A","N/A","No"]
[5442,"81.BR ; (ADAR2—/—/AGluR-B<R/R>)","B6;129-Adarb1<tm1Phs> Gria2<tm1.1Phs>",null,"Recessive","adenosine deaminase, RNA-specific, B1","Adarb1","Reduced","ADAR2, D10Bwg0447e, RED1","MGI:891999","adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg","Adarb1<tm1Phs>","MGI:2178079","10",{"$nulls":15},"No",{"$nulls":12},"No abnormal phenotype detected: double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)","Adarb1<tm1Phs>/Adarb1<tm1Phs>Gria2<tm1.1Phs>/Gria2<+>Postnatal lethality: compound mutant mice survive up to P35 (partial rescue; extended postnatal survival).","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","Unknown",null,null,"No","2011-02-17","Cryopreserved sperm",49,0,null,null,"true",null,"Maarten","Kole","The Australian National University","maarten.kole@anu.edu.au",{"$nulls":3},"Maarten","Kole","maarten.kole@anu.edu.au","J.NS.41.08","9.20","No"]
[5442,"81.BR ; (ADAR2—/—/AGluR-B<R/R>)","B6;129-Adarb1<tm1Phs> Gria2<tm1.1Phs>",null,"Recessive","glutamate receptor, ionotropic, AMPA2 (alpha 2)","Gria2",null,"Glur-2, GluR-B, GluR2, Glur2","MGI:95809","glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1.1, Peter H Seeburg","Gria2<tm1.1Phs>","MGI:2178125","3",{"$nulls":15},"Yes",{"$nulls":42},"Maarten","Kole","maarten.kole@anu.edu.au","J.NS.41.08","9.20"]
[4516,null,"ENU8C:011",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm",60,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[7262,"LysM-Cre Rb","B6(Cg)-Lyz2<tm1(cre)Ifo> Rb1<tm3Tyj>/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Normal","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":28},"No obvious phenotype. No effect on lifespan, breeding or skeleton","None observed. LysM-Cre mice are ok as both heterozygous and homozygous alleles","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5","unknown/not collected","LysM-Creki/+ pRBfl/+ male to LysM-Creki/+ pRBfl/+ female","No","2013-01-18","Cryopreserved sperm",50,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","SABC025","IBC168","No"]
[7262,"LysM-Cre Rb","B6(Cg)-Lyz2<tm1(cre)Ifo> Rb1<tm3Tyj>/StvApb",null,"Dominant","lysozyme 2","Lyz2 ","Nil","Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp ","MGI:96897","lysozyme 2; targeted mutation 1, Irmgard Forster ","Lyz2tm1(cre)Ifo","MGI:1934631","10",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","SABC025","IBC168"]
[7244,"CMV-cre","C57BL/6-Tg(CMV-cre)1Cgn/WehiArcApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, University of Cologne","human cytomegalovirus (CMV) promoter",{"$nulls":11},"Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-12-11","Embryo",0,0,"ARC",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A","N/A","No"]
[5297,"CD39 KO","C57BL/6-Entpd1<tm1Rdr>",null,"Recessive","ectonucleoside triphosphate diphosphohydrolase 1","Entpd1","Nil","Cd39, ectoapyrase, NTPDase-1","MGI:102805","ectonucleoside triphosphate diphosphohydrolase 1; targeted mutation 1, Robert D Rosenberg","Entpd1<tm1Rdr>","MGI:2182811","19",{"$nulls":15},"No",{"$nulls":12},"Cardiac fibrosis.Abnormal blood flow velocity: terminal erythrocyte velocity is increased (17.1+/-5.2 compared to 3.3+/-3.3 mm per second in wild-type mice).Abnormal vascular endothelial cell physiology: ATPase and ADPase activities are substantially decreased compared to in wild-type mice.Decreased platelet cell number: platelet count is 20% lower than in wild-type mice (538+/-78x103 per mm3 compared to 740+/-81x103 per mm3 in wild-type mice).Decreased platelet aggregation: * in vitro, platelets fail to aggregate in response to ADP, collagen or low doses of thrombin. * however, treatment with a soluble potato ATPase restores aggregation response.Increased bleeding time: * bleed time is increased to greater than 20 minutes in 4 mice and greater than 7 minutes in 7 mice compared to 1.0+/-0.2 minutes in heterozygous mice. * treatment with ferric chloride revealed a delay in platelet plug formation with no thrombi formation after 20 minutes compared to 100% in wild-type mice.Abnormal neutrophil physiology: * polymorphonuclear (PMN) cells fail to convert etheno-AP into etheno-AMP as do wild-type PMNs. * following activation, the supernatant surrounding PMNs accumulate 1.6+/-0.09-fold more ATP than from wild-type PMNs. * unactivated PMN supernatant accumulates more ATP than wild-type.Fibrosis: mice exhibit increased fibrin deposits in the lungs, heart and spleen and in some mice the liver, kidney and brainPulmonary fibrosis: fibrin deposits are present in the lungs and worsen after thrombogenic challenge.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm",50,0,null,"St V #1","false",null,"Anthony","D'Apice","St Vincent's Hospital Melbourne","anthony.dapice@svhm.org.au",{"$nulls":3},"Anthony","D'Apice","anthony.dapice@svhm.org.au","N/A","N/A","No"]
[5367,"NODTNFR1","NOD.Cg-Tnfrs1a<tm1Blt>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Unknown","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-alpha-R1, TNF-alphaR1, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Horst Bluethmann","Tnfrsf1a<tm1Blt>","MGI:1861040","6",{"$nulls":15},"No",{"$nulls":12},"Absent follicular dendritic cells: organized follicular dendritic cell networks are absent.Abnormal Peyer's patch morphology: the typical subepithelial dome areas fail to form.Abnormal Peyer's patch follicle morphology: B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent.Decreased Peyer's patch number: * average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice * however, T cell populations in the thymus and T and B cell populations in the spleen and lymph nodes are normal.Abnormal lymph node B cell domain: B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however B cells are present and B and T cell areas are segregated.Abnormal immune system physiology.Increased susceptibility to type I hypersensitivity reaction: significant reduction in bronchoalveolar lavage leukocytosis in an ovalbumin-induced allergic asthma model.Decreased interleukin-6 secretion: LPS-induced IL-6 secretion is reduced about 3-fold compared to wild-type mice; however TNF secretion is similar to wild-type.Increased susceptibility to bacterial infection: * infection with as few as 250 colony forming units of Listeria monocytogenes results in 100% mortality by 6 days after infection, all wild-type mice survive this treatment. * D-galactosamine sensitized homozygotes can survive 100-fold higher concentrations of LPS than wild-type; however without D-galactosamine sensitization both types of mice show similar sensitivity to LPS-induced mortality. * however, homozygotes are able to control infections of lymphocytic choriomeningitis virus.Increased susceptibility to parasitic infection: * T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice * however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #63","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7246,"MLC-hAP","C57BL/6-Tg(Myl1-AP)1Nros/MarpApb",null,"Semi-dominant",{"$nulls":25},"human alkaline phosphatase","myosin light chain (MLC)",{"$nulls":10},"Unknown","Normal.Expression of human alkaline phosphatase in skeletal muscle.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-12-12","Cryopreserved sperm",70,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MAS-ARMI-2010-11BC","PC1-N54-10","No"]
[1640,"Bailey","C57BL/6-Col2a1<tm1>",null,"Recessive","procollagen, type II, alpha 1","Col2a1","Normal","Col2a, Col2a-1, Del1","MGI:88452",{"$nulls":3},"15",{"$nulls":15},"Yes",{"$nulls":12},"Mice have shortened and deformed limbs.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-17",null,0,0,null,null,"true",null,"Amanda","Fosang","Murdoch Childrens Research Institute","amanda.fosang@mcri.edu.au",{"$nulls":3},"Amanda","Fosang","amanda.fosang@mcri.edu.au","N/A","N/A","No"]
[5947,"NfixKO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4478,null,"129-Nos2<tm1Mrl>/AnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Unknown","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, John S Mudgett","Nos2<tm1Mrl>","MGI:2158791","11",{"$nulls":15},"No",{"$nulls":14},"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-02-22","Cryopreserved sperm",120,0,"ANU",null,"false",null,"David","Willenborg","The Australian National University","david.willenborg@anu.edu.au",{"$nulls":3},"Sue","Fordham","sue.fordham@anu.edu.au","N/A","N/A","No"]
[7254,"FTL-BALB/C","BALB/c-Tg(fos-tau/LacZ)/Apb",null,"Dominant",{"$nulls":25},"FOS-TAU-LACZ","C-FOS","Distribution and expression similar to engogenous c-fos",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent",">30",null,"FTL+ FEMALE X FTL+ MALE","No","2013-01-09","Cryopreserved sperm",40,0,null,null,"false",null,"Mark","Murphy","The University of Melbourne","m.murphy@unimelb.edu.au",{"$nulls":3},"Yvette","Wilson","y.wilson@unimelb.edu.au","1011698.1","1246/2004","No"]
[5298,"CD39.Tg","C57BL/6-Tg(H2-K<b>-ENTPD1)",null,"Dominant",{"$nulls":25},"human ectonucleoside triphosphate diphosphohydrolase-1","H2-K<b>",{"$nulls":11},"Human CD39 (hCD39) is widely expressed in transgenic mice.hCD39 prolongs bleeding times and protects against induced thrombosis.AMP and adenosine levels are increased in hCD39 transgenic mice.hCD39 protects transgenic mouse cardiac grafts from Ab-mediated rejection.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm",50,0,null,"St V #4","false",null,"Anthony","D'Apice","St Vincent's Hospital Melbourne","anthony.dapice@svhm.org.au",{"$nulls":3},"Anthony","D'Apice","Anthony.dapice@svhm.org.au","N/A","N/A","No"]
[350,"p75<NTR>","129-Ngfr<tm1Jae>",null,"Recessive","nerve growth factor receptor (TNFR superfamily, member 16)","Ngfr","Unknown","LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16","MGI:97323","targeted mutation 1, Rudolf Jaenisch","Ngfr<tm1Jae>","MGI:1857226","11",{"$nulls":15},"No",{"$nulls":12},"Viable and fertile.Homozygotes for targeted mutations exhibit increased perinatal lethality, skin abnormalities, growth retardation, reduced sensory nerve innervation, elevated pain threshold, ataxia, reduced sciatic nerve diameter, and blood vessel abnormalities.Decreased sensory innervation by calcitonin gene-related peptide- and substance P-immunoreactive fibers.The defective innervation was correlated with loss of heat sensitivity and associated with the development of ulcers in the distal extremities. Complicated by secondary bacterial infection, the ulcers progressed to toenail and hair loss. ",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-09-29",null,0,0,null,null,"true",null,"Xin-Fu","Zhou","Flinders University","xin-fu.zhou@flinders.edu.au",{"$nulls":3},"Xin-Fu","Zhou","xin-fu.zhou@flinders.edu.au","N/A","N/A","No"]
[7261,"APN246","C57BL/6N(Ag)-Casp9<tm1a(EUCOMM)Hmgu>MarpApb",null,"Recessive","caspase 9","Casp9 ",null,"Caspase-9, ICE-LAP6, Mch6 ","MGI:1277950 ","\tcaspase 9; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH ","Casp9tm1a(EUCOMM)Hmgu","MGI:4950193","4",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-17","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[1706,"Gin","C57BL/6-Tg(Col2a1-cre)1Asz",null,"Dominant",{"$nulls":25},"transgene insertion 1, Attila Aszodi","Cartilage specific Col2a1 gene promoter",{"$nulls":10},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-25",null,0,0,null,null,"true",null,"Amanda","Fosang","Murdoch Childrens Research Institute","amanda.fosang@mcri.edu.au",{"$nulls":3},"Amanda","Fosang","amanda.fosang@mcri.edu.au","N/A","N/A","No"]
[5615,"B2ca",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5616,"B2M",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[2745,"NSXR","B6.CBA-Tg(Sox3-EGFP)NrPqt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion Nr, Paul Q Thomas","Sox3 promoter","High level of expression at restricted regions in CNS",{"$nulls":9},"N/A as transgenic line is maintained at hemizygous state state","High level of expression at restricted regions in CNS. Hydrocephalus with at least 10% penetrance.","CBA x C57BL/6","No","No","Yes","No","No","Yes","No","Poor",null,null,"Tg/+ male to wt female","No","2008-02-10","Cryopreserved sperm",130,0,null,null,"false",null,"Paul","Thomas","The University of Adelaide","paul.thomas@adelaide.edu.au",{"$nulls":3},"Paul","Thomas","paul.thomas@adelaide.edu.au","N/A","N/A","No"]
[6334,"STAT6/Blimp424","C57BL/6-Prdm1<tm1Nutt> Stat6<tm1Aki>",null,"Semi-dominant","PR domain containing 1, with ZNF domain ","Prdm1 ","Normal","Blimp-1, Blimp1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt ","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1703","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6334,"STAT6/Blimp424","C57BL/6-Prdm1<tm1Nutt> Stat6<tm1Aki>",null,"Semi-dominant","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034 ","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":61},"N/A","N/A"]
[3558,null,"C57BL/6-Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn Ptprc<b>/Wehi",null,"Recessive",{"$nulls":25},"transgene insertion L118-1, Francis R Carbone ","a 2 kb fragment of the H-2Kb and a 700 bp fragment including the Igh enhancer.",{"$nulls":10},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-01",null,0,0,null,"WEHI #1298","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5299,"B6.TBM.Tg","C57BL/6-Tg(H2-K<b>-THBD)",null,"Dominant",{"$nulls":25},"human thrombomodulin","H2-K<b>","Strong on peripheral blood lymphocytes",{"$nulls":10},"hTBM transgenic mice were indistinguishable from WT littermates in appearance, size, level of activity and fertility.Transgenically expressed hTBM protects against pulmonary arterial thromboembolism.Transgenically expressed hTBM protects against venous thrombosis.Transgenically expressed hTBM reduces the inflammatory infiltrate after IVC ligation.Transgenically expressed hTBM reduces HMGB1 levels.Transgenically expressed hTBM prolongs cardiac graft survival and reduces infiltrating T cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05","Cryopreserved sperm",50,0,null,"St V #5","false",null,"Anthony","D'Apice","St Vincent's Hospital Melbourne","anthony.dapice@svhm.org.au",{"$nulls":3},"Anthony","D'Apice","Anthony.dapice@svhm.org.au","N/A","N/A","No"]
[3582,null,"Rb(12.T17<16>65Dn)2Cje",null,"Dominant",null,null,"Increased","Ts(Rb(12.17<16>))2Cje",null,"Robertsonian translocation, Chr 12 and T1716Dn, Charles J Epstein 2","Rb(12.T17<16>65Dn)2Cje","MGI:3531161","Unknown",{"$nulls":15},"Yes",{"$nulls":12},"This strain has three copies of most of the genes on mouse Chromosome16 that are homologues of human Chromosome 21 genes. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04",null,0,0,null,"WEHI #1586","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hscott@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8575,"LGN-VenusC","B6.Cg-Gpsm2<tm1.1(Venus)Fuma>/FumaVcccApb",null,"Dominant","G-protein signalling modulator 2 (AGS3-like, C. elegans)","Gpsm2",null,"6230410J09Rik, LGN, Pins","MGI:1923373","G-protein signalling modulator 2 (AGS3-like, C. elegans); targeted mutation 1.1, Fumio Matsuzaki","Gpsm2<tm1.1(Venus)Fuma>","MGI:3850859","3",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-27",null,0,40,null,null,"false",null,"Patrick","Humbert","La Trobe Institute of Medical Science","P.Humbert@latrobe.edu.au",{"$nulls":3},"Samantha","McIntosh","S.McIntosh@latrobe.edu.au",null,null,"No"]
[6738,"Klf3-8-bY-FV","FVBn-tm<Klf3>.Klf8GT. tg(bYAC)/Ausb",null,"Recessive",null,"Klf3,Klf8,bYAC",{"$nulls":35},"Embryonic lethalDouble homozygous is 100% embryonic lethal. Klf3KO homozygote is 50% embryonic lethal. KlfKO/Klf8 het is 90% embryonic lethal. Klf8KO has no obvious pheontype. bYAC expresses human globin genes- no affect on mouse.",null,"FVBn","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2621","true",null,"Richard","Pearson","The University of New South Wales","richard.pearson@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7362,"Grhl3 flox","B6.129S1-Grhl3<tm3.1Jane>/MarpApb",null,"Recessive","grainyhead-like 3 (Drosophila)","Grhl3","Normal",null,"MGI:2655333","grainyhead-like 3 (Drosophila); targeted mutation 3.1, Stephen M Jane","Grhl3<tm3.1Jane>","MGI:5306651","4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"fl/fl x fl/fl","No","2013-06-26","Cryopreserved sperm",37,0,"Monash",null,"false",null,"Stephen","Jane","Monash University","stephen.jane@monash.edu",{"$nulls":3},"Darren","Partridge","darren.partridge@monash.edu","B/BL-2011/378IL","PC2-N19/11","No"]
[7136,"LRRK1","C57BL/6N-Lrrk1<tm1.1Youy>/JAusb","C57BL/6N-Lrrk1<tm1.1Youy>/JAusb","Recessive",null,"LRRK1",null,null,"MGI:4940302",{"$nulls":34},"C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"Moss Vale","2939","true",null,"Nicolas","Dzamko","The University of New South Wales","n.dzamko@neura.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7082,"Momme D31","FVB/NJ-Trim28<MommeD31> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","tripartite motif-containing 28 ","Trim28","Unknown","KAP-1, KRIP-1, Tif1b","MGI:109274","tripartite motif-containing 28; modifier of murine metastable epialleles, D31","Trim28<MommeD31>",null,"7",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Death at E6-E8","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD31<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-09-13","Cryopreserved sperm",40,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[3538,null,"C57BL/6-Prdm1<tm1Nutt> /  Pou2af1<tm1Pmt>",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Blimp T/T mice die late in gestation, regardless of OBF-1 genotype  ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29",null,0,0,null,"WEHI #1071","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[3538,null,"C57BL/6-Prdm1<tm1Nutt> /  Pou2af1<tm1Pmt>",null,"Recessive","POU domain, class 2, associating factor 1","Pou2af1","Unknown","Bob-1, BOB.1, Bob1, OBF-1, OBF.1, OCA-B, OCAB","MGI:105086","targeted mutation 1, Patrick Matthias","Pou2af1<tm1Pmt>","MGI:2388055","9",{"$nulls":58},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A"]
[5008,"Hbdd5.1","C57BL/6-Ptprc<a> Hbb<d>",null,"Dominant",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","C57BL/6 mice express the a allele of Ptprc and the d allele of hemoglobin beta chain. Both alleles are homozygous.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",100,0,null,null,"true",null,"David","Curtis","Walter and Eliza Hall Institute of Medical Research","dcurtis@wehi.edu.au",{"$nulls":3},"David","Curtis","dcurtis@wehi.edu.au","N/A","N/A","No"]
[5008,"Hbdd5.1","C57BL/6-Ptprc<a> Hbb<d>",null,"Dominant",{"$nulls":28},"hemoglobin beta chain complex","Hbb",null,null,"MGI:96020","hemoglobin beta chain complex; d","Hbb<d>","MGI:1858119","7","C57BL/6 mice express the a allele of Ptprc and the d allele of hemoglobin beta chain. Both alleles are homozygous.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",{"$nulls":4},"true",{"$nulls":8},"David","Curtis","dcurtis@wehi.edu.au","N/A","N/A"]
[7257,"MLC:2IGF-1B_3D (Class 2Eb) ; SP2-IGF-1Eb","B6.FVB-Tg(Myl1-SP2/IGF1Eb)1Nros/MarpApb","B6.FVB-Tg(Myl1-SP2/IGF1Eb)1Nros","Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain","skeletal muscle",{"$nulls":9},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MARP-2011-038-BC ","PC1-N54-10","No"]
[7363,"RhoGEF19 flox","B6.129S1-Arhgef19<tm1Jane>/Marp",null,"Recessive","Rho guanine nucleotide exchange factor (GEF) 19","Arhgef19","Normal","6430573B13Rik, WGEF","MGI:1925912","Rho guanine nucleotide exchange factor (GEF) 19, targeted mutation 1 Stephen Jane","Arhgef19<tm1Jane>",null,"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"fl/fl x fl/fl","No","2013-06-27","Cryopreserved sperm",47,0,"Monash",null,"true",null,"Stephen","Jane","Monash University","stephen.jane@monash.edu",{"$nulls":3},"Darren","Partridge","darren.partridge@monash.edu","B/BL-2011/437IL","PC2-N19/11","No"]
[4812,"ENU8BAT:070:Wash","C57BL/6JSfdAnu-Henmt1<m1Anu>/AnuApb",null,"Recessive","HEN1 methyltransferase homolog 1 (Arabidopsis)","Henmt1","Unknown","4921515J06Rik, Hen1","MGI:1913965",{"$nulls":3},"3","ENSMUSG00000045662","ENSMUST00000106586","4921515J06Rik-204",{"$nulls":7},"108745775","3",null,null,"ATTTAGTGGATCGCCATGAACCCAAGAAGGTAATTATTATTATTATTATTGTTATTATTA","Yes",{"$nulls":12},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",125,0,"ANU",null,"true",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[7258,"MLC-Cre","B6.FVB-Tg(Myl1-cre)13Nros/MarpApb","B6.FVB-Tg(Myl1-cre)13Nros","Semi-dominant",{"$nulls":25},"Tg(Myl1-cre)13Nros","myosin light chain (MLC)",{"$nulls":10},"Unknown","Normal.Expression of cre recombinase in skeletal muscle.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-01-15","Cryopreserved sperm",54,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MARP-2011-038-BC ","PC1-N54-10","No"]
[7310,"K5rTA-Rae1-32","C57BL/6-Tg(K5-rTA)04Cbn Tg(TetO-RaeT1e)32Cbn/Apb",null,"Dominant",{"$nulls":25},"tetracycline-regulated transcriptional transactivator","bovine keratin-5",{"$nulls":10},"In these mice following oral doxycyline treatment, rTA expresssion induced in the skin activates the TetO promoter driving RaeT1e expression in the skin.Following doxycycline treatment, RaeT1e expression is weak in these mice.","As for homozygous mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"4","Tg Tg x Tg Tg","No","2013-04-09","Cryopreserved sperm",45,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","1112345","2011-032","No"]
[{"$nulls":30},"retinoic acid early transcript 1E","CMV minimal promoter and 7 TetO sequences"]
[3589,"Balb/c-Blimp KO","BALB/c-Prdm1<tm1Nutt>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Prenatal lethality - homozygotes die late in gestation.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-05",null,0,0,null,"WEHI #1694","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":3},"Lynn","Corcoran","corcoran@wehi.edu.au","N/A","N/A","No"]
[3625,null,"C57BL/6.129S4-Cxcl10<tm1Adl>",null,"Recessive","chemokine (C-X-C motif) ligand 10","Cxcl10","Nil","C7, CRG-2, gIP-10, Ifi10, INP10, IP-10, IP10, mob-1, Scyb10","MGI:1352450","targeted mutation 1, Andrew D Luster","Cxcl10<tm1Adl>","MGI:2180678","5",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal cytokine secretion * only CCL2 levels are elevated in corneas relative to wild-type or Cxcl9-null mice after HSV-1 infectionIncreased susceptibility to experimental autoimmune encephalomyelitis * higher incidence and greater severity of experimental autoimmune encephalomyelitisCNS inflammation * experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days* monocytes lymphocytes and some granulocytes are involved* increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodesIncreased susceptibility to viral infection * 7 days after infection (day 7 pi) with herpes simplex virus type I (HSV-1), homozygotes have significantly higher HSV-1 titers in the cornea * virus shedding in the tear film is elevated at day 7 pi but not at early points relative to Cxcl9 homozygotes or wild-type controls* mice usually succumb to infection between days 7 and 9 pi",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12",null,0,0,null,"WEHI #2090","true",null,"Diana","Hansen","Walter and Eliza Hall Institute of Medical Research","hansen@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1743,"Bcl-x KO","C57BL/6-Bcl2l1<tm1Dlo>/Wehi",null,"Recessive","Bcl2-like 1","Bcl2l1","Nil","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; targeted mutation 1, Dennis Y Loh","Bcl2l1<tm1Dlo>","MGI:2158303","2",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.","Decreased platelet cell number:* platelet counts are significantly lower than controls (860x10<3>/microliter vs 1100x10<3>/microliter).Abnormal platelet physiology:* platelet half-life is significantly reduced compared to controls (57 hours to 30 hours).","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,null,"WEHI #90","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1783,"Cathepsin B knockout","B6.129-Ctsb<tm1Jde>/Wehi",null,"Recessive","cathepsin B","Ctsb","Nil",null,"MGI:88561","targeted mutation 1, Jan Deussing","Ctsb<tm1Jde>","MGI:2182129","14",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations are born normal without gross abnormalities. Homozygous mutant has resistance to induced pancreatitis. ",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #469","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1762,"E mu-myc","C57BL/6-Tg(IghMyc)22Bri/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 22, Ralph L Brinster","Igh (E mu) enhancer and Myc promoter",{"$nulls":11},"Mice invariably develop lymphomas, 90% succumbing in the first 5 mo of life. to almost invariably develop lymphomas, 90% succumbing in the first 5 mo of life. The tumors typically presented as rapidly progressive lymphadenopathy with thymic involvement and were highly malignant by transplantation assay. Morphologically, they were lymphoblastic lymphomas, usually accompanied by lymphoid leukemia and granulocytosis, and were distinct from the tumors that arose much later in 37% of nontransgenic mice of the same (C57BL/6 x SJL)F2 genetic background.Premature death: mice die at 6 to 15 weeks of age with 94% of mice dying by 4 months of age.Increased tumor incidence: mice occasionally develop thyoma without involvement of peripheral lymphoid organsLeukemia: mice develop multicentric lymphosarcoma associated with leukemia.Lymphoma:* 13 of 15 mice develop lymphomas* mice develop multicentric lymphosarcoma associated with leukemia.B cell derived lymphoma: lymphomas develop from single B-lymphoid clones at different stages of differentiation.Sarcoma: mice develop multicentric lymphosarcoma associated with leukemia.Abnormal lymphopoiesis: mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice.Enlarged spleen: two-fold.Enlarged thymus.Enlarged lymph nodes.","C57BL/6 x SJL","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,null,"true",null,"Jerry","Adams","Walter and Eliza Hall Institute of Medical Research","adams@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1757,"Bmf Deleted Line 372","C57BL/6-Bmf<tm1Anvi>/Wehi",null,"Recessive","Bcl2 modifying factor","Bmf","Normal",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Andreas Villunger","Bmf<tm1Anvi>","MGI:3778609","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #309","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6210,"KO50/266","B6.129S2-Bcl2l11<tm1Ast> Trp53<tm1Tyj>",null,"Recessive","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2181","true",null,"Clare","Scott","Walter and Eliza Hall Institute of Medical Research","scottc@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6210,"KO50/266","B6.129S2-Bcl2l11<tm1Ast> Trp53<tm1Tyj>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod ","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":61},"N/A","N/A"]
[3548,null,"C57BL/6-Tg(Cd11c-mOVA) Cst3<tm1Karl>",null,"Recessive","cystatin C","Cst3","Nil","CysC, cystatin C","MGI:102519","cystatin C; targeted mutation 1, S Karlsson","Cst3<tm1Karl>","MGI:2182140","2",{"$nulls":15},"Yes","membrane bound ovalbumin (chicken) mOVA","CD11c (mouse)",{"$nulls":10},"Normal. Transgenic mice express membrane bound ovalbumin under the control of the CD11c promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-30",null,0,0,null,"WEHI #1165","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7761,"Nsun2-GGTC","B6.129-Nsun2<Gt(D014D11)Wrst>/Ausb",null,"Recessive","NOL1/NOP2/Sun domain family member 2","Nsun2","Nil","Misu","MGI:107252","NOL1/NOP2/Sun domain family member 2; gene trap D014D11, German Gene Trap Consortium","Nsun2<Gt(D014D11)Wrst>","MGI:3873208","13",{"$nulls":28},"Alopecia:• cyclic alopecia develops at around 10 months• normal pelage develops after birthAbnormal hair cycle:• a reduced number of hair follicle bulge stem cells are found in S- or G2/M-phase at the initiation of anagen (day 21 of age)• progression of hair follicle cells through the cell cycle is slower• a 2 fold increase in bulge stem cells is found during telogenAbnormal hair cycle anagen phase:• delayed entry of hair follicles into first and second synchronized hair cycleDecreased body size:• appreciably smaller than controlsMale infertility:• males are sterile",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09",null,0,0,"ABR - Moss Vale","3856","true",null,"John","Mattick","Garvan Institute","director@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[5102,"129.Cat-L","129-Ctsl<tm1Cptr>/Wehi",null,"Recessive","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564",null,null,"MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"129","Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2010-04-29",null,0,0,null,"WEHI #364","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1770,"C3H.Cat-L","C3H-Ctsl<tm1Cptr>/Wehi",null,"Recessive","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"C3H","Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #363, 364","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5173,"Cx40.350 ; Tie2Cx40.350","B6;CBA-Tg(Tie2-Gja5<DN350>)/ABS",null,"Dominant","gap junction protein, alpha 5","Gja5","Increased","connexin 40, Cx40, Gja-5","MGI:95716",{"$nulls":3},"Unknown",{"$nulls":16},"overexpression of Cx40","Tie2 endothelial specific",{"$nulls":10},"Unknown","unknown","N3 B6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","3",null,null,"No","2010-07-06","Cryopreserved sperm",45,0,null,null,"true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au","Building 131, Garran Road","Acton","ACT","Klaus","Matthaei","Klaus.Matthaei@anu.edu.au","JMB.33.07, JNS43.08, ","NLRD ANUID 8.14","No"]
[6535,"IR1?","B6.129S2-Ifnar1<tm1Agt>/ScrAusb",null,"Recessive","interferon (alpha and beta) receptor 1 ","Ifnar1","Nil","Ifar, IFN-alpha/betaR, Ifrc","MGI:107658","interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet","Ifnar1<tm1Agt>","MGI:1930950","16",{"$nulls":28},"Abnormal osteoclast morphology:*Osteoclastogenesis is enhanced.Impaired NK cell cytolysis:*Natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells.Decreased interferon-alpha secretion:*Following infection with Leishmania.Decreased interferon-beta secretion:*Following infection with Leishmania.Abnormal response to infection:*Murine cytomegalovirus replication in macrophages is increased greater than 10,000-fold compared to that in wild-type macrophages.Increased tumor growth/size:*In mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice.Decreased bone mineral density",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","397","true",null,"Jonathan","Sprent","Garvan Institute","j.sprent@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[5152,null,"ENU7B6:039 (ANA)",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6JStdAnu X CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2","1",null,"No","2010-06-11","Cryopreserved sperm",40,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Lina","Tze","lina.tze@anu.edu.au","J.IG.31.04","N/A","No"]
[4957,"BALB/c-Homo Rosa EGFP<tg1>","BALB/c-Gt(ROSA)26Sor<tm1(GAP43)Gld> Alpl<tm1(cre)Nagy",null,"Dominant","alkaline phosphatase, liver/bone/kidney","Alpl","Unknown","Akp-2, Akp2, TNAP, TNSALP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Martyn Goulding",{"$nulls":12},"Expression of GFP in all cells.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-18",null,0,0,null,null,"true",null,"Chris","Parish","The Australian National University","chris.parish@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","A.BS.01.09","N/A","No"]
[6905,"APN 259","C57BL/6N-Ift140<tm1a(KOMP)Wtsi>/Marp",null,"Recessive","intraflagellar transport 140 homolog (Chlamydomonas)","Ift140 ","Unknown","mKIAA0590, Tce5, Wdtc2 ","MGI:2146906 ","\tintraflagellar transport 140 homolog (Chlamydomonas); targeted mutation 1a, Wellcome Trust Sanger Institute ","Ift140tm1a(KOMP)Wtsi","MGI:4363217","17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-06-01","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu","Monash University","Clayton","Vic","Leanne","Cotton","leanne.cotton@monash.edu","MAS/2010/08","PC1-N09/07","No"]
[1771,"Cathepsin-S/Cathepsin-L Knockout","Un-Ctsl<tm1Cptr> Ctss<tm1Hap>/Wehi",null,"Dominant","cathepsin L","Ctsl","Nil","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","3",{"$nulls":15},"No",{"$nulls":12},"Deficient CD4 T cell generation (but not \"visibly\" immunocompromised). Periodic partial hair loss. ",null,null,"No","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #365","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1771,"Cathepsin-S/Cathepsin-L Knockout","Un-Ctsl<tm1Cptr> Ctss<tm1Hap>/Wehi",null,"Dominant","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"No",{"$nulls":45},"N/A","N/A"]
[6225,"Ly5.1/gBT-1/Rel","B6.129-Ptprc<a> Rel<tm1Brv> Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn",null,"Semi-dominant","protein tyrosine phosphatase, receptor type, C","Ptprc","Normal","B220, CD45, Ly-5, Lyt-4, T200 ","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":16},"transgene insertion L118-1, Francis R Carbone",{"$nulls":13},"C57BL/6 then Ly5.1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1442","true",null,"Gabrielle","Belz","Walter and Eliza Hall Institute of Medical Research","belz@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6225,"Ly5.1/gBT-1/Rel","B6.129-Ptprc<a> Rel<tm1Brv> Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn",null,"Semi-dominant","reticuloendotheliosis oncogene","Rel","Normal","c-Rel","MGI:97897","reticuloendotheliosis oncogene; targeted mutation 1, Rodrigo Bravo ","Rel<tm1Brv>","MGI:3639342","11",{"$nulls":61},"N/A","N/A"]
[1782,"Cathepsin-S Knockout","B6;129-Ctss<tm1Hap>/Wehi",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #456","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1809,null,"Cathepsin H knockout",null,"Recessive","cathepsin H","Ctsh","Unknown","Cat H","MGI:107285",{"$nulls":3},"1",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #844","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1810,"Cathepsin W knockout","Un-Ctsw<tm1Ctnp>",null,"Recessive","cathepsin W","Ctsw","Nil","lymphopain","MGI:1338045","cathepsin W; targeted mutation 1, Christine T N Pham","Ctsw<tm1Ctnp>","MGI:3046638","19",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #845","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6916,"FVBNJ-Momme D23","FVB/NJ-Smchd1<MommeD23> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SMC hinge domain containing 1","Smchd1",null,"4931400A14Rik, mKIAA0650, MommeD1","MGI:1921605","SMC hinge domain containing 1; modifiers of murine metastable epiallele D1","Smchd1<MommeD23>",null,"17",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human α-Globin (-570 to +37) (4.1kb of enhancer)","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm",40,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","P1224","No"]
[205,"Nkx2-5 KO","C57BL/6-Nkx2-5<tm4Rph>/Apb",null,"Dominant","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Nil","Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","targeted mutation 4, Richard P Harvey","Nkx2-5<tm4Rph>","MGI:3655239","17",{"$nulls":15},"Yes",{"$nulls":12},"Arrested cardiac development, death E9.5-10","atrial septal abormalities, AV conduction defect","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-20","Cryopreserved sperm",40,0,null,null,"false",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[1818,"Ts1Cje","B6.Cg-Ts(16C-tel)1Cje",null,"Dominant",null,null,"Unknown",null,null,"trisomy, Chr 12 translocation to Chr 16, Charles J Epstein","Ts(1216)1Cje","MGI:3623022","12",{"$nulls":15},"Yes",{"$nulls":12},"Down Syndrome. Behavioral and learning difficulties.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,"WEHI","973","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6227,"B6PLT16","C57BL/6-Bcl2l1<Plt16>",null,"Semi-dominant","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; platelet 16","Bcl2l1<Plt16>","MGI:3847886","2",{"$nulls":28},"Partial prenatal lethality:*Very few fetuses survive until birth.","Decreased platelet cell number:*Platelet counts are significantly lower than controls (596x10<3>/microliter vs 1100x10<3>/microliter).Increased megakaryocyte cell number:*Megakaryocyte numbers are marginally elevated compared to controls.Abnormal platelet physiology:*Platelet half-life is significantly reduced compared to controls (57 hours to 30 hours).","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2166","true",null,"Doug","Hilton","Walter and Eliza Hall Institute of Medical Research","hilton@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1817,"Rac2 knockout","C57BL/6-Rac2<tm1Mddw>/Wehi",null,"Recessive","RAS-related C3 botulinum substrate 2","Rac2","Nil",null,"MGI:97846","targeted mutation 1, Mary C Dinauer and David A Williams","Rac2<tm1Mddw>","MGI:1857701","15",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9",null,null,"No","2007-08-06",null,0,0,null,"WEHI #959","true",null,"Andrew","Roberts","Walter and Eliza Hall Institute of Medical Research","roberts@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1833,"Blimp1 / Rag 2 knockout","C57BL/6-Prdm1<tm1Nutt> Rag2<tm1Fwa>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp1, PRDI-BF1","MGI:99655","targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)",{"$nulls":11},"Blimp-1 homozygotes die late gestation.Rag 2 homzygotes are immunocompromised ",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08",null,0,0,null,"WEHI #1097","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1833,"Blimp1 / Rag 2 knockout","C57BL/6-Prdm1<tm1Nutt> Rag2<tm1Fwa>/Wehi",null,"Recessive","recombination activating gene 2","Rag2","Unknown","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2",{"$nulls":61},"N/A","N/A"]
[7762,"Nsun2-EuComm","C57BL/6N-Nsun2<tm1a(EUCOMM)Wtsi>/Ausb",null,"Recessive","NOL1/NOP2/Sun domain family member 2","Nsun2","Nil","Misu","MGI:107252","NOL1/NOP2/Sun domain family member 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Nsun2<tm1a(EUCOMM)Wtsi>","MGI:4432654","13",{"$nulls":28},"Decreased body size:• appreciably smaller than controlsMale infertilitybehavior/neurologicaldecreased grip strength ( J:175295 )\tWTSI (J:175295)hyperactivity ( J:175295 )\tWTSI (J:175295)craniofacialabnormal cranium morphology ( J:175295 )WTSI (J:175295)abnormal tooth morphology ( J:175295 )WTSI (J:175295)abnormal snout morphology ( J:175295 )\tWTSI (J:175295)short snout ( J:175295 )\tWTSI (J:175295)upturned snout ( J:175295 )\tWTSI (J:175295)growth/sizedecreased percent body fat ( J:175295 )\tWTSI (J:175295)decreased total body fat amount ( J:175295 )WTSI (J:175295)abnormal tooth morphology ( J:175295 )WTSI (J:175295)abnormal snout morphology ( J:175295 )\tWTSI (J:175295)short snout ( J:175295 )\tWTSI (J:175295)upturned snout ( J:175295 )\tWTSI (J:175295)decreased lean body mass ( J:175295 )WTSI (J:175295)decreased body weight ( J:165965 , J:175295 )WTSI (J:175295)\tEuPh (J:165965)decreased body length ( J:175295 )WTSI (J:175295)hematopoietic systemincreased erythrocyte cell number ( J:175295 )WTSI (J:175295)decreased mean corpuscular hemoglobin ( J:175295 )WTSI (J:175295)decreased mean corpuscular volume ( J:175295 )WTSI (J:175295)homeostasis/metabolismdecreased circulating glucose level ( J:175295 )WTSI (J:175295)decreased circulating cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating HDL cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating LDL cholesterol level ( J:175295 )\tWTSI (J:175295)decreased circulating free fatty acid level ( J:175295 )\tWTSI (J:175295)decreased circulating glycerol level ( J:175295 )\tWTSI (J:175295)decreased circulating amylase level ( J:175295 )\tWTSI (J:175295)decreased energy expenditure ( J:175295 )\tWTSI (J:175295)increased energy expenditure ( J:175295 )\tWTSI (J:175295)increased carbon dioxide production ( J:175295 )\tWTSI (J:175295)increased oxygen consumption ( J:175295 )\tWTSI (J:175295)improved glucose tolerance ( J:175295 )\tWTSI (J:175295)integumentabnormal hair cycle anagen phase ( J:175295 )\tWTSI (J:175295)limbs/digits/tailabnormal humerus morphology ( J:175295 )WTSI (J:175295)abnormal deltoid tuberosity morphology ( J:175295 )WTSI (J:175295)skeletonabnormal cranium morphology ( J:175295 )WTSI (J:175295)abnormal humerus morphology ( J:175295 )WTSI (J:175295)abnormal deltoid tuberosity morphology ( J:175295 )WTSI (J:175295)abnormal spine curvature ( J:175295 )WTSI (J:175295)kyphosis ( J:175295 )WTSI (J:175295)lordosis ( J:175295 )\tWTSI (J:175295)decreased bone mineral content ( J:175295 )WTSI (J:175295)decreased bone mineral density ( J:175295 )WTSI (J:175295)abnormal joint morphology ( J:175295 )WTSI (J:175295)vision/eyeabnormal cornea morphology ( J:175295 )WTSI (J:175295)abnormal lens morphology ( J:175295 )WTSI (J:175295)cataracts ( J:175295 )WTSI (J:175295)",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2014-10-09",null,0,0,"ABR - Moss Vale","3857","true",null,"John","Mattick","Garvan Institute","director@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[1853,"PGK-Cre","Un-Tg(Pgk1-cre)1Lni",null,"Dominant",{"$nulls":25},"transgene insertion 1, Peter Lonai","Phosphoglycerate kinase","dominant maternal control",{"$nulls":9},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1367","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7289,"TCRF5","B6(Cg)-Tg(Cd2-TcraF5,CD2-TcrbF5)1Kio/AnuApb","B6(Cg)-Tg(Cd2-TcraF5,CD2-TcrbF5)1KioAnu","Dominant",{"$nulls":25},"transgene insertion 1, Dimitris Kioussis","CD2 minigene",{"$nulls":10},"This clone is CD8+ and recognises amino acids 366-374 of the nucleoprotein (NP 366-374) of influenza virus (A/NT/60/68), in the context of Class I MHC Db (Townsend et al., 1986). The usage of V beta 11 makes this TcR reactive to Class II IE molecules and an endogenous ligand recently identified as a product of the endogenous mammary tumour viruses (Mtv) 8, 9, and 11 (Dyson et al., 1991). The development of F5 transgenic T cells and their function in mice of the appropriate MHC (C57BL/10 H-2b, IE-) or in mice expressing Class II MHC IE (e.g., CBA/Ca H-2k and BALB/c H-2d) and the endogenous Mtv ligands. Positive selection of CD8+ T cells expressing the V beta 11 is seen in C57BL/10 transgenic mice (H-2b). Peripheral T cells from these mice are capable of killing target cells in an antigen-dependent manner after a period of in vitro culture with IL-2. In the presence of Class II MHC IE molecules and the endogenous Mtv ligand, most of the single-positive cells carrying the transgenic T-cell receptor are absent in the thymus. Unexpectedly, CD8+ peripheral T-cells in these (H-2k or H-2d) F5 mice are predominantly V beta 11 positive and also have the capacity to kill targets in an antigen-dependent manner. This is true even following backcrossing of the F5 TcR transgene to H-2d scid/scid mice, in which functional rearrangement of endogenous TcR alpha- and beta-chain genes is impaired.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-03-18","Cryopreserved sperm",27,0,"ANU","022","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4724,"Gpx1 -/-","B6.129-Gpx1<tm1Kola>/MarpApb",null,"Recessive","glutathione peroxidase 1","Gpx1","Unknown","cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1","MGI:104887","targeted mutation 1, Ismail Kola","Gpx1<tm1Kola>","MGI:2388705","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-09","Cryopreserved sperm",100,0,"Monash",null,"false",null,"Paul","Hertzog","Monash University","paul.hertzog@med.monash.edu.au",{"$nulls":3},"Paul","Hertzog","paul.hertzog@med.monash.edu.au","N/A","N/A","No"]
[1846,null,"Un-Tg(ACTB-ECFP)1Nagy/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion CK6, Andras Nagy","chicken beta actin promoter coupled with the cytomegalovirus (CMV) immediate early enhancer",{"$nulls":10},"Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. All tissues from these animals display fluorescence in all cell types under appropriate lighting conditions, except in erythrocytes and adipocytes where fluorescence is negligible or absent.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1267","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1852,null,"Jaw1 knockout",null,"Recessive","lymphoid-restricted membrane protein","Lrmp","Unknown","D6Int3, D6Int4, D6Int5, D6Int7, D6Int8, Jaw1","MGI:108424",{"$nulls":3},"6",{"$nulls":15},"Yes",{"$nulls":12},"Males are sterile. Females are normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1361","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1854,null,"5'endothelial Cre ER-T",null,"Dominant",{"$nulls":25},"Cre recombinase",{"$nulls":14},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1395","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[308,"Inbred Athymic Nude","BALB/c-Foxn1<nu>/Arc",null,"Recessive","forkhead box N1","Foxn1","Unknown","D11Bhm185e, Hfh11, whn","MGI:102949","nude","Foxn1<nu>","MGI:1856108","11",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:some mice die within 1 week of birth55% mortality within 2 weeksPremature death:100% mortality by 25 weeksDecreased body size and weight.Postnatal growth retardation.Abnormal T cell differentiation.Athymia.Abnormal cell-mediated immunity.Abnormal liver morphology:liver lobes were atrophied and covered with red scarsvariable degrees of severity, typically increasing with age at time of death.Small ovaryCoiled sperm flagellum: many sperm had coiled tailsAbnormal estrous cycle: many females exhibited continuous dioestrus and metaoestrus phasesFemale infertility: severely reduced fertilityReduced male fertility.Asthenozoospermia.Nude: sparse hair growth around 5 weeks of agein some mice, cephalo-caudal migration of an irregular band of short sparse hairThin skin:reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skinAbsent vibrissae: absent at birthShort and wavy vibrissae: older mice show repeated growth and loss of short and wavy vibrissae.","Have hair. Enlarged thymus","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","michael.Hall@arc.wa.gov.au",{"$nulls":3},"Michael","Hall","Michael.Hall@arc.wa.gov.au","N/A","N/A","No"]
[4735,"Analiese","ENU5WT:035",null,"Recessive",null,null,"Unknown",null,null,"Analiese",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"9",null,"No","2009-04-19","Cryopreserved sperm",40,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[7305,"RIP-mOVA","C57BL/6-Tg(Ins2-TFRC/OVA)Wehi/WehiApb",null,"Dominant",{"$nulls":25},"transgene insertion, Walter and Eliza Hall Institute of Medical Research","rat insulin 2",{"$nulls":10},"Normal. Mice express OVA in the pancreas beta cells and kidney proximal tubular cells. There is low level expression in the testes. No thymic expression detected but when crossed to OT-I TCR Tg mice, the OT-I T cells were deleted indicating low levels of OVA expression in the thymus.","Normal","C57BL/6","No","Unknown","Yes","No","Unknown","Yes","No","Good",null,">30","Tg x C57BL/6","No","2013-04-05","Cryopreserved sperm",50,0,null,null,"false",null,"William","Heath","The University of Melbourne","wrheath@unimelb.edu.au",{"$nulls":3},"Gayle","Davey","daveyg@unimelb.edu.au","1112326","2011-032","No"]
[4543,null,"C57BL/6-Eed<l7Rn5-3354SB>",null,"Recessive","embryonic ectoderm development","Eed","Nil","l(7)5Rn, l7Rn5","MGI:95286","lethal, Chr 7, Rinchik 5, 3354SB","Eed<l7Rn5-3354SB>","MGI:1856856","7",{"$nulls":15},"Yes",{"$nulls":12},"Lethal shortly after implanatation, extra-embryonic tissue defects",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Good","2",null,"Het x WT","No","2009-03-01",null,0,0,null,null,"true",null,"Marnie","Blewitt","Walter and Eliza Hall Institute of Medical Research","blewitt@wehi.edu.au",{"$nulls":3},"Marnie","Blewitt","blewitt@wehi.edu.au","N/A","N/A","No"]
[6645,"NOD.BID","NOD.B6-Bid<tm1.1Ast>/WehiStvApb",null,"Dominant","BH3 interacting domain death agonist","Bid","Nil","2700049M22Rik","MGI:108093","BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser","Bid<tm1.1Ast>","MGI:4440571","6",{"$nulls":28},"Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas wild-type mice normally die from hepatocellular apoptosis and hemorragic necrosisHomozygous null mice develop spontaneous type 1 diabetes at the same incidence as wild-type NOD mice.","Normal","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","10","Sister x Brother (hom x hom)","Yes","2011-11-14","Cryopreserved sperm",50,0,"St V",null,"false",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":3},"Stacey","Fynch","sfynch@svi.edu.au","016/11","073","Yes"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin alpha chain complex","Hba","Nil",null,"MGI:96014","hemoglobin alpha chain complex; targeted mutation 1, Timothy Townes","Hba<tm1(HBA)Tow>","MGI:3790755","11",{"$nulls":28},"Display sickle cell disease. Mice develop anemia from 3 weeks of age. Lethality occurs at variable rates (after 3 months).  ","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"heterozygous intercrosses","No","2014-04-08","Cryopreserved sperm",60,0,"Monash",null,"true",null,"Fiona","Brown","Monash University","fiona.brown2@monash.edu",{"$nulls":3},"Fiona","Brown","fiona.brown200@gmail.com","B/BL-2011/452IL","PC2-N17/11","No"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin beta chain complex","Hbb","Nil",null,"MGI:96020","hemoglobin beta chain complex; targeted mutation 2, Timothy Townes","Hbb<tm2(HBG1,HBB*)Tow>","MGI:3790753","7",{"$nulls":58},"Fiona","Brown","fiona.brown200@gmail.com","B/BL-2011/452IL","PC2-N17/11"]
[7654,"Hbbtm2(HBG1,HBB*)Tow","C57BL/6-Hba<tm1(HBA)Tow> Hbb<tm2(HBG1,HBB*)Tow> Hbb<tm3(HBG1,HBB)Tow>/MarpApb",null,"Dominant","hemoglobin beta chain complex","Hbb",null,null,"MGI:96020","hemoglobin beta chain complex; targeted mutation 3, Timothy Townes","Hbb<tm3(HBG1,HBB)Tow>","MGI:3790756","7",{"$nulls":58},"Fiona","Brown","fiona.brown200@gmail.com","B/BL-2011/452IL","PC2-N17/11"]
[7341,"MommeD43","FVB/NJ-Setdb1<MommeD43> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","SET domain, bifurcated 1","Setdb1","Unknown","ESET, KMT1E, mKIAA0067","MGI:1934229","SET domain, bifurcated 1; modifiers of murine metastable epiallele D43","Setdb1<MommeD43>",null,"3","ENSMUSG00000015697","ENSMUST00000015841","Setdb1-005",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Normal","Percentage of cells expressing the GFP transgene is decreased (enhancer of variegation).","FVB/NJ","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm",45,0,"QIMR",null,"false",null,"Joanne","Sutton","Queensland Institute of Medical Research","joanne.sutton@qimr.edu.au",{"$nulls":6},"A0812609","P1224/2009","No"]
[1731,"Eµ-BCL2-36","B6.Cg-Tg(Bcl2)36Wehi/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 36, Walter and Eliza Hall Institute of Medical Research","Emu immunoglobulin heavy chain enhancer and SV40 promoter.",{"$nulls":11},"Increased B cell number: mutants show an excess of B lymphocytesIncreased T cell number: mutants have an excess of T lymphocytes.Abnormal B cell physiology: * transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes.Increased immunoglobulin level:* mice display increased serum immunoglobulin concentrationsAbnormal T cell physiology:* transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes.Increased susceptibility to autoimmune disorder:* some transgenic mice develop a systemic autoimmune-like disease.T cell derived lymphoma:* a few mice develop fatal clonal T cell tumors.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,null,"WEHI #46","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4702,"NOD.MRL(C3)-Fas<lpr>/LtJ","NOD.Cg-Fas<lpr>/Apb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.",null,"NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",95,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[291,null,"CBA/CaH-Tg(Il5)1Glx",null,"Dominant",{"$nulls":25},"Interleukin 5, IL5","locus control region (LCR) from the gene encoding the T-cell surface antigen CD2",{"$nulls":10}," The IL-5 mice are macroscopically normal apart from an enlarged spleen which contains numerous eosinophiles at various stages of differentiation. Homozygous mice have higher numbers of eosinophils than heterozygotes but are difficult to breed.","Heterozygous mice have about 8 copies of the IL-5 gene and show a life long blood and tissue eosinophilia.","CBA/CaH","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03",null,0,0,null,null,"true",null,"Lindsay","Dent","The University of Adelaide","lindsay.dent@adelaide.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3500","true",null,"Philippe","Bouillet","Walter and Eliza Hall Institute of Medical Research","bouillet@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":61},"N/A","N/A"]
[6230,"Bak/Bmf/472 ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":61},"N/A","N/A"]
[4517,"anda","ENU8C:014",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[5154,"RRFUR","BALB/c-FLii<tm1Hdc> Gt(ROSA)26Sor<tm1.1(FLII)Hdc>/AnuApb",null,"Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fliih","MGI:1342286","flightless I homolog (Drosophila); targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Hugh D Campbell","SV40","Human FLII is not expressed until genetic exposure to Cre recombinase",{"$nulls":9},"Normal. Rescue of embryonic lethal phenotype of Flii<tm1Hdc> strain.","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","4",null,"Hom x Hom","No","2010-06-15","Cryopreserved sperm",39,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","J.MB.20.04","N/A","No"]
[5215,"mIMPα4FL (very low level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)verylow",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","very low level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-08-30","Cryopreserved sperm",20,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[4116,"Crimpy","ENU12WT:012a",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"First coat appears as wavy or crimped. Affected mice shed coat at 3-5 weeks. New coat growth is short, dense and dull. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",30,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"anusha","subramanium","anusha.subramanium@anu.edu.au","J.APF.13.08","N/A","No"]
[5538,"APN 112","C57BL/6N-Ptpn22<tm1a(EUCOMM)Wtsi>/Marp",null,"Recessive","protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ","Ptpn22","Unknown","70zpep, Ptpn8 ","MGI:107170 ","protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1a, Wellcome Trust Sanger Institute ","Ptpn22tm1a(EUCOMM)Wtsi","MGI:4434268","3",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-07-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"The Australian","Phenomics Network","Monash University","leanne.cotton@monash.edu",null,"Clayton","Victoria","Leanne","Cotton","leanne.cotton@monash.edu","N/A","N/A","No"]
[5603,"Ancient 2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5605,"Ancient Group 1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5305,"Galectin-3 KO","129/Sv;B6;SJL-Lgals3<tm1Poi>",null,"Recessive","lectin, galactose binding, soluble 3","Lgals3","Nil","gal3, galectin-3, L-34, Mac-2","MGI:96778","lectin, galactose binding, soluble 3; targeted mutation 1, Francoise Poirier","Lgals3<tm1Poi>","MGI:2183057","14",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"129/Sv x C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05",null,0,0,null,"St V #177","true",null,"Anthony","D'Apice","St Vincent's Hospital Melbourne","Anthony.Dapice@svhm.org.au",{"$nulls":3},"Anthony","D'Apice","Anthony.Dapice@svhm.org.au","N/A","N/A","No"]
[1759,"Bcl-2 KO","C57BL/6-Bcl2<tm1Dlo>/Wehi",null,"Recessive","B-cell leukemia/lymphoma 2","Bcl2","Nil","Bcl-2","MGI:88138","targeted mutation 1, Dennis Y Loh","Bcl2<tm1Dlo>","MGI:2156165","1",{"$nulls":15},"No",{"$nulls":12},"Homozygotes are runted because they develop polycystic kidney disease. They normally die within 6 weeks from birth. They are also profoundly lymphopenic and they turn grey at the second hair follicle cycle because of the death of melanocyte precursors. These defects are corrected by the concomitant loss of Bim.Postnatal lethality: about 50% die between 1 and 6 weeks after birth.Abnormal coat color: hair color turns gray postnatally between 4 and 5 weeks, however skin is normal.Decreased body size.Decreased body weight: body weight is 30-90% of controls.Small ears.Decreased lymphocyte cell number: number of lymphocytes in the peripheral blood, bone marrow, thymus, spleen, and lymph nodes decreases with age, while the number of segmented neutrophils and other hematopoietic lineages is normal.Decreased pre-B cell number: more than 80% reduction of B220+ surface immunoglobulin-negative pre-B cells in the bone marrow.Decreased mature B cell number: more than 80% reduction of B220+/surface immunoglobulin-positive mature B cells in the bone marrow.Decreased CD8-positive T cell number: accelerated decrease over time in the percentage of CD4-CD8+ cells in the periphery.Decreased thymocyte number.Abnormal T cell differentiation.Abnormal kidney morphology: kidneys have a nonsmooth surface, are pale, and exhibit interstitial hyperproliferation.Abnormal kidney cortex: disarray of the cortex structureDecreased renal glomerulus number.Abnormal kidney medulla morphology: disarray of the medulla structure.Small kidney.Dilated renal tubules: dilated renal tubules with hypertrophic epithelium.Polycystic kidney: kidneys exhibit a polycystic appearancerespiratory system.Abnormal nose morphology: rounder nose.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #428","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1811,"K5-mOVA","Un-Tg(K5-mOVA)",null,"Dominant",{"$nulls":25},"membrane bound chicken ovalbumin","Keratin 5",{"$nulls":10},"Normal. Mice express membrane bound ovalbumin in keratinocytes.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #846","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4600,"Epo-R-Cre pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Rb1<tm3Tyj>/Apb",null,"Dominant","retinoblastoma 1","Rb1","Unknown","pRb, Rb, Rb-1","MGI:97874","targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":15},"Yes",{"$nulls":12},"Compound mutant: Mild anaemia.  Single Epo-R-Cre – lethal as homozygous, heterozygous maintained only.  Single pRbfl/fl – no phenotype until Cre exposed",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Epor<tm1(EGFP/cre)Uk> -ve  Rb1<tm3Tyj> female x Epor<tm1(EGFP/cre)Uk> +ve  Rb1<tm3Tyj> het male","No","2009-03-13","Cryopreserved sperm",39,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":3},"Carl","Walkley","cwalkley@svi.edu.au","N/A","N/A","No"]
[4600,"Epo-R-Cre pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Rb1<tm3Tyj>/Apb",null,"Dominant","erythropoietin receptor","Epor","Unknown",null,"MGI:95408","erythropoietin receptor; targeted mutation 1, Ursula Klingmuller","Epor<tm1(EGFP/cre)Uk>","MGI:3052727","9",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","N/A","N/A"]
[6907,"ENU15NIH49a","C57BL/6JAnu-Satb1<m1Anu>/AnuApb","C57BL/6JAnu-Satb1<m1Anu>/AnuApb","Dominant","special AT-rich sequence binding protein 1","Satb1","Unknown","2610306G12Rik ","MGI:105084","special AT-rich sequence binding protein 1; mutation 1, The Australian National University","Satb1<m1Anu>","MGI:5563413","17","ENSMUSG00000023927","ENSMUST00000144331","Satb1-001","1179","1416","T to A","ENSMUSE00000322390","7","393","Phenylalanine to Leucine",{"$nulls":4},"AAACGAGCCGGAATCTCACAGGCAGTATTTGCACGCGTGGCTTTTAACCGAACTCAGGGAT",{"$nulls":13},"Reduced expression of CD44 on CD4<+> and CD8<+> T cells","Intermediate phenotype of reduced expression of CD44 on CD4<+> and CD8<+> T cells","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"7",null,"No","2012-06-08","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","Chris.Goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","2011/41",null,"No"]
[7343,"MommeD45","FVB/NJ-Klf1<MommeD45> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Dominant","Kruppel-like factor 1 (erythroid)","Klf1","Normal","Eklf, Nan","MGI:1342771","Kruppel-like factor 1 (erythroid); modifiers of murine metastable epiallele D45","Klf1<MommeD45>",null,"8","ENSMUSG00000054191","ENSMUST00000067060","Klf1-201",{"$nulls":12},"Yes","transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"GFP transgene  expression levels are increased (suppressor of variegation) in MommeD45.","GFP transgene  expression levels are increased (suppressor of variegation) in MommeD45.","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-05-27","Cryopreserved sperm",45,0,"QIMR",null,"false",null,"Joanne","Sutton","Queensland Institute of Medical Research","joanne.sutton@qimr.edu.au",{"$nulls":6},"A0812609","P1224/2009","No"]
[5084,"Cas-L KO","C57BL/6-Nedd9<tm1Miku>/AnuApb",null,"Recessive","neural precursor cell expressed, developmentally down-regulated gene 9","Nedd9","Nil","Cas-L, CasL, E230025G09Rik, HEF1","MGI:97302","neural precursor cell expressed, developmentally down-regulated gene 9; targeted mutation 1, Mineo Kurokawa","Nedd9<tm1Miku>","MGI:3700233","13",{"$nulls":15},"No",{"$nulls":12},"Abnormal B cell number.Increased follicular B cell number: follicular zone B cells (FOB, B-2 cells) are concomitantly increased.Decreased lymphocyte cell number: there are reduced lymphocyte numbers in peripheral lymphoid organs in mutants.Decreased marginal zone B cell number: marginal zone B cell numbers are reduced in mutants, as shown by reduced CD1d<high> cell numbers or IgM<high>IgD<low> cell numbers.Spleen hypoplasia: splenocyte number is ~50% of wild-type; both B and T cell numbers are reduced, with B cells more affected.Lymph node hypoplasia: total number of lymphocytes and numbers of T and B cells is significantly reduced compared to wild-type.Abnormal follicular B cell physiology: follicular zone B cells show aberrant migration and adhesion in response to chemotactic stimuli, compared to wild-type cells.Abnormal leukocyte migration: mutant splenocytes injected into wild-type hosts show abnormal homing with numbers of homing mutant cells found in spleen and lymph nodes decreased compared to wild-type cells.Abnormal T cell physiology: splenic T cells show attenuated responses to chemotactic (CXCL12 and CCL21) stimuli.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-04-09","Cryopreserved sperm",50,0,"ANU",null,"false",null,"David","Linares","The Canberra Hospital","david.linares@anu.edu.au",{"$nulls":3},"Sue","Fordham","sue.fordham@anu.edu.au","N/A","N/A","No"]
[5627,"B6.129-Tg(APPSw)40Btla/J ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3414,"RIP-mOVA","C57BL/6-Tg(Ins2-TFRC/OVA)296Wehi/wehi",null,"Dominant",{"$nulls":25},"transgene insertion 296, Walter and Eliza Hall Institute of Medical Research","rat insulin 2","Limited to pancreas",{"$nulls":9},"Express membrane bound ovalbumin in pancreas.",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14",null,0,0,null,"WEHI #128","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5533,"B6NT","C57BL/6-Tg(Nup98-Top1)/MarpApb",null,"Dominant",{"$nulls":25},"Nup98-top1 fusion","Topoisomerase I",{"$nulls":10},"Normal.Normal blood counts at 6mo, no anemia, lymphopenia or thrombocytopenia in mice aged to 600 days","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sibling matings; transgenic male with wildtype female","No","2011-07-07","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Christopher","Slape","Monash University","christopher.slape@monash.edu",{"$nulls":3},"Jesslyn","Saw","jesslyn.saw@monash.edu","0809249","340/2002","No"]
[4986,"K14-Frem1","C57BL/6-Tg(KRT14-Frem1)",null,"Dominant",{"$nulls":25},"Fras1 related extracellular matrix protein 1","keratin 14 (K14)",{"$nulls":10},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-01-27","Cryopreserved sperm",63,0,null,null,"true",null,"Ian","Smyth","Monash University","ian.smyth@med.monash.edu.au",{"$nulls":3},"Ian","Smyth","ian.smyth@med.monash.edu.au","N/A","N/A","No"]
[5611,"AtF3ko",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5612,"B Arrestin KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4797,"PLJ","PLJ",null,"Dominant",{"$nulls":37},"Normal",null,"PLJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",110,0,"ANU",null,"false",null,"David","Willenborg","The Canberra Hospital","sue.fordham@anu.edu.au",{"$nulls":6},"A.BS.01.09","N/A","No"]
[6904,"APN125","C57Bl/6N-Ptcra<tm2a(EUCOMM)Hmgu>/Marp",null,"Recessive","pre T cell antigen receptor alpha","Ptcra","Unknown","pT-alpha, pT[a], pTalpha","MGI:104857","pre T cell antigen receptor alpha; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH","Ptcratm2a(EUCOMM)Hmgu","MGI:4434686","17",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-31","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu","Monash University","Clayton","Vic","Leanne","Cotton","leanne.cotton@monash.edu","MAS/2010/08","PC1-N09/07","No"]
[1980,"Smad1f x Myl2VCre","129;Swiss-Smad<tm2Rob> Myl2<tm1(cre)Krc>",null,"Recessive","MAD homolog 1 (Drosophila)","Smad1","Nil","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":15},"Yes",{"$nulls":12},"Deletion of Smad1 and Myl2 in myosin light polypeptide 2, regulatory, cardia c, slow expressing cells.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1980,"Smad1f x Myl2VCre","129;Swiss-Smad<tm2Rob> Myl2<tm1(cre)Krc>",null,"Recessive","myosin, light polypeptide 2, regulatory, cardiac, slow","Myl2","Unknown","MLC-2, MLC-2v, Mlc2v, Mylpc","MGI:97272","myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien","Myl2<tm1(cre)Krc>","MGI:2385922","5",{"$nulls":61},"N/A","N/A"]
[1976,null,"C57BL/6J-TgN(A<2>K<b>HLA)6HsdArc",null,"Recessive",{"$nulls":25},"Human HLA A<2> specific for H-2K<b>?",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2007-09-04",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","MIchael.Hall@arc.wa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[4926,null,"B6;129-Gfpt2<Gt(352F9)Cmhd>/Apb",null,"Recessive","glutamine fructose-6-phosphate transaminase 2","Gfpt2","Unknown","GFAT2","MGI:1338883","glutamine fructose-6-phosphate transaminase 2; gene trap 352F9, Centre for Modeling Human Disease","Gfpt2<Gt(352F9)Cmhd>","MGI:4965721","11",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-11-11","Cryopreserved sperm",90,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.unsw.edu.au","N/A","N/A","No"]
[7353,"Gnat2c.518A>G","BALB/c-Gnat2<A518G>/MelbApb",null,"Recessive","guanine nucleotide binding protein, alpha transducing 2","Gnat2","Normal","Gnat-2, Gt-2, Tcalpha ","MGI:95779","Gnat2c.518A>G",null,null,"3",{"$nulls":28},"This mouse shows no evidence of cone photoreceptor function as measured by the electroretinogram. This lack of function probably results from a misfolding of the Gnat2 protein. There is also retinal remodelling, opsin mislocalisation by 3 months, increasing in severity by 12 months. At 12 months there is evidence of cone photoreceptor cell loss. At these late ages, there is also evidence of rod phototreceptor functional loss. ","Unknown","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","approximately 4","unknown",null,"No","2013-06-17","Cryopreserved sperm",50,0,null,null,"false",null,"Erica","Fletcher","The University of Melbourne","elf@uniemlb.edu.au",{"$nulls":3},"Andrew","Jobling","aij@unimelb.edu.au","1112260",null,"Yes"]
[276,"TgN(IGF-1)","FVB-Tg(Myl1-Igf1)1Nros",null,"Recessive",{"$nulls":25},"transgene insertion 1, Naida Rosenthal"," regulatory elements from the rat myosin light chain (MLC)-1/3 locus","MSkeletal muscle specific",{"$nulls":11},"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-01",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[1988,"Nkx2-5Cre x Nodal flox","129-Nkx2-5<tm2(cre)Rph> Nodal<tmMku>/Apb",null,"Recessive","Nodal","Nodal","Unknown",null,"MGI:97359",{"$nulls":3},"10",{"$nulls":15},"Yes",{"$nulls":12},"Deletion of Nodal in Nkx2-5 expressing cells.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05","Cryopreserved sperm",50,0,"Victor Chang",null,"false",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1988,"Nkx2-5Cre x Nodal flox","129-Nkx2-5<tm2(cre)Rph> Nodal<tmMku>/Apb",null,"Recessive","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Unknown","Csx, Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","NK2 transcription factor related, locus 5 (Drosophila); targeted mutation 2, Richard P Harvey","Nkx2-5<tm2(cre)Rph>","MGI:2448972","17",{"$nulls":61},"N/A","N/A"]
[1984,"T-box 2","129-Tbx2<tm1Pa>",null,"Recessive","T-box 2","Tbx2","Nil",null,"MGI:98494","T-box 2; targeted mutation 1, Virginia Papaioannou","Tbx2<tm1Pa>","MGI:3505715","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethality during organogenesis: at E12.5 some homozygous embryos are dead.Abnormal atrioventricular canal morphology: at E10.5 the atrioventricular canal fails to constrict in some mutant embryos.   embryonic lethality throughout fetal growth and development.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1989,"MesP1Cre x PitX2flox","Un.129-Pitx2<tm1Sac> Mesp1<tm2(cre)Ysa>",null,"Recessive","paired-like homeodomain transcription factor 2","Pitx2","Normal","Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin","MGI:109340","paired-like homeodomain transcription factor 2; targeted mutation 1, Sally Camper","Pitx2<tm1Sac>","MGI:1857844","3",{"$nulls":15},"No",{"$nulls":12},"Deletion of PitX2 in MesP1 expressing cells",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1989,"MesP1Cre x PitX2flox","Un.129-Pitx2<tm1Sac> Mesp1<tm2(cre)Ysa>",null,"Recessive","mesoderm posterior 1","Mesp1","Normal","bHLHc5","MGI:107785","mesoderm posterior 1; targeted mutation 2, Yumiko Saga","Mesp1<tm2(cre)Ysa>","MGI:2176467","7",{"$nulls":61},"N/A","N/A"]
[1990,"MesP1Cre x Nodal flox","Un-Nodal<tmMku> Mesp1<tm2(cre)Ysa>",null,"Recessive","nodal","Nodal","Nil",null,"MGI:97359",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Deletion of Nodal gene in cells expressing MesP1.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-05",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1990,"MesP1Cre x Nodal flox","Un-Nodal<tmMku> Mesp1<tm2(cre)Ysa>",null,"Recessive","Mesoderm posterior 1","Mesp1","Normal","bHLHc5","MGI:107785","mesoderm posterior 1; targeted mutation 2, Yumiko Saga","Mesp1<tm2(cre)Ysa>","MGI:2176467","7",{"$nulls":61},"N/A","N/A"]
[4526,null,"B6.CBA-Tg(hGMCSF-CK1m)394/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm",30,0,"ANU","186","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[7053,"A33 hfneo","B6;129/Sv-Gpa33<tmhfneo>/LudApb",null,"Recessive","glycoprotein A33 (transmembrane)","Gpa33","Unknown","2010310L10Rik, 2210401D16Rik, A33 antigen","MGI:1891703",{"$nulls":3},"1",{"$nulls":28},"This strain shows no phenotypic signs different from wildtype","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-08-21","Cryopreserved sperm",50,0,"Ludwig","ME-40","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09",null,"No"]
[6774,"DBC2 Flpe ; BRINP2  Flpe","C57BL/6-Brinp2<tm1.2Pib>/PibMarpApb",null,"Recessive","bone morphogenic protein/retinoic acid inducible neural-specific 2","Brinp2","Normal","DBC2, Fam5b, 6430517E21Rik, mKIAA1747","MGI:2443333","bone morphogenic protein/retinoic acid inducible neural-specific 2; targeted mutation 1.2, Phillip I Bird","Brinp2<tm1.2Pib>","MGI:5604617","1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-01-11","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Phil","Bird","Monash University","phil.bird@monash.edu",{"$nulls":3},"Susie","Berkowicz","Susie.berkowicz@monash.edu","SOBS/B/2008/30BC","N/A","No"]
[7247,"MLC:2IGF-1A_1C (Class 2Ea) ; SP2-IGF-1Ea","STOCK Tg(Myl1-Igf1)?Nros/MarpApb",null,"Semi-dominant",{"$nulls":25},"mouse insulin-like growth factor-1","myosin light chain",{"$nulls":10},"Transgenic IGF-1 propeptides are retained in skeletal muscle.E peptides bind to heparin agarose.IGF-1 E peptide moieties bind to extracellular matrix.","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-12-12","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Nadia","Rosenthal","Australian Regenerative Medicine Institute","nadia.rosenthal@monash.edu",{"$nulls":3},"Nadia","Rosenthal","nadia.rosenthal@monash.edu","MARP-2011-038-BC","PC1-N54-10","No"]
[7374,"CB28-KO","B6.129-Calb1<tm1Mpin>/Apb",null,"Dominant","calbindin 1","Calb1",null,"Brain-2, Calb, Calb-1, calbindin, calbindin-D (28k), CalbindinD28K, CB","MGI:88248","calbindin 1; targeted mutation 1, Max-Planck-Institute for Neurobiology","Calb1<tm1Mpin>","MGI:1857460","4",{"$nulls":28},"Ataxia• mutants do not display ataxia in standard environments; when challenged (with a runway test or rotarod test) coordination is severely disturbed compared to controls• mice display a shaky tremor which usually worsens during movement; controls do not show any tremors","Ataxia• 2-month old heterozygotes show significant deficits in initial trials in a thin horizontal rod test compared to controls but are significantly better than homozygotes; after first 2 sessions, no significant difference remains between mutant groups","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-07-11","Cryopreserved sperm",50,0,null,null,"false",null,"Michael","Hubbard","The University of Melbourne","mike.hubbard@unimelb.edu.au",{"$nulls":3},"Jon","Mangum","jon.mangum@unimelb.edu.au","0911511.1","2010/033","No"]
[6612,"ENU19WT 019:G2","ANU:ENU19WT:019:G2",null,"Semi-dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-11","Cryopreserved sperm",10,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","A2011/41","N/A","No"]
[7264,null,"Ggn KO (-Neo)",null,"Recessive","gametogenetin","Ggn","Unknown","GGN1, GGN2, GGN3","MGI:2181461",{"$nulls":3},"7",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic Lethal","Appear normal, not studied extensively.","C57BL/6J x129Sv","No","No","Yes","No","No","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-21","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Duangporn","Jamsai","Monash University","duangporn.jamsai@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[1995,"TgN(IGF) x Chisel KO","B6.129-Smpx<tm1.1Rph> Tg(IGF1)",null,"Recessive","small muscle protein, X-linked","Smpx","Nil","chisel, Csl","MGI:1913356","targeted mutation 1, Richard P Harvey","Smpx<tm1Rph>","MGI:2387819","X",{"$nulls":15},"Yes","insulin like growth factor 1, IGF 1",{"$nulls":14},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-07",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","R.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1815,null,"Interferon consensus binding protein knockout",null,"Semi-dominant","interferon regulatory factor 8","Irf8","Unknown","ICSBP, Icsbp1, IRF-8, Myls","MGI:96395",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Lack CD8+ dendritic cells33% moribund by 50 weeks. Haematological neoplasis, develop leukaemia with age.Abnormal haemopoiesis. Increased susceptibility to viral infection .","9% moribund by 50 weeks. Haematological neoplasia.","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #910","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[2330,null,"C57BL/6-Prf1<tm1sdz> Ifng<tm1Ts> Tg(TcraTcrb)1100Mjb",null,"Recessive","perforin 1","Prf1","Nil","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-04",null,0,0,null,"ABS #009","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[2330,null,"C57BL/6-Prf1<tm1sdz> Ifng<tm1Ts> Tg(TcraTcrb)1100Mjb",null,"Recessive","interferon gamma","Ifng","Unknown","Ifg, IFN-gamma","MGI:107656","targeted mutation 1, Timothy Stewart","Ifng<tm1Ts>","MGI:1857184","10",{"$nulls":61},"N/A","N/A"]
[4950,"Light -/- IFNgR -/-","C57BL/6-Tnfsf14<tm1Kpf> Ifngr1<tm1Agt>",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 14","Tnfsf14","Nil","HVEM-L, LIGHT","MGI:1355317","tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Klaus Pfeffer","Tnfsf14<tm1Kpf>","MGI:2671122","17",{"$nulls":28},"In the experimental model of Active EAE we found no significant difference between the LIGHT-/-IFN GAMMA R-/-BL6 strain and the IFN GAMMA R -/-BL6 strain in both the EAE disease development and daily clinical score.  At the time of termination of experimentation the mice from both the experimental groups were of a similar severe level of EAE disease in comparison with the significantly lower level of EAE in the C57/BL6/Wt control mice. There was also no histopathological difference in the brain and spinal cord samples of the two experimental groups at the completion of the EAE experiment.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-12-04","Cryopreserved sperm",100,0,null,null,"true",null,"Paula","Mana","The Canberra Hospital","paula.mana@anu.edu.au",{"$nulls":3},"Sue","Fordham","sue.fordham@anu.edu.au","F.MS.17.09","NLRD 1952/2006","No"]
[4950,"Light -/- IFNgR -/-","C57BL/6-Tnfsf14<tm1Kpf> Ifngr1<tm1Agt>",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","interferon gamma receptor 1; targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","Unknown",{"$nulls":58},"Sue","Fordham","sue.fordham@anu.edu.au","F.MS.17.09","NLRD 1952/2006"]
[3482,"C57BL/6.CD45 -/-","C57BL/6-Ptprc<tm1Tyb>/Wehi",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Nil","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810","targeted mutation 1, Victor L J Tybulewicz","Ptprc<tm1Tyb>","MGI:3579087","1",{"$nulls":15},"No",{"$nulls":12},"Increased NK cell number:* four- and fivefold increase in the percentage of NK1.1+CD49b+TCR-Beta- NK cells in the spleen and liver, respectively, however percentage of NK precursors was normal.* increase in the turnover of NK cells in the spleen but not liver.Abnormal NK cell physiology:* NK cells secrete less cytokines and chemokines when immunoreceptor tyrosine-based activation motif (ITAM)-containing surface receptors are stimulated.* no calcium flux in NK cells after Ly49D stimulationAbnormal chemokine physiology: Ly49D-stimulated NK cells produce 100-1000-fold less MIP-1alpha and MIP-1beta than controls.Abnormal cytokine secretion: Ly49D-stimulated NK cells secrete less IFN-gamma.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,null,"WEHI #570","true",null,"David","Tarlinton","Walter and Eliza Hall Institute of Medical Research","tarlinton@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5307,"17FOX 025 B6.129-Tg(FoxP3-GFP)","ENU17FOX:025 Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Hyper-IgE phenotypedetected at 10 weeks of age or later.Cells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-11-08","Cryopreserved sperm",20,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":6},"J.APF.19.08","N/A","No"]
[5307,"17FOX 025 B6.129-Tg(FoxP3-GFP)","ENU17FOX:025 Foxp3<tm2Ayr>",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown",{"$nulls":45},"J.APF.19.08","N/A"]
[5949,"Nodal ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3497,null,"BALB/c-H2<k>",null,"Dominant","histocompatibility-2, MHC","H2","Unknown","H-2, MHC-II","MGI:95894","k variant","H2<k>","MGI:3579322","17",{"$nulls":15},"Yes",{"$nulls":12},"Balb/c is usually H2<d>. The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-24",null,0,0,null,"WEHI #808","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[7380,"Batf3 KO","B6.129-Batf3<tm1Kmm>/MelbAnuApb",null,"Recessive","basic leucine zipper transcription factor, ATF-like 3","Batf3","Nil","9130211I03Rik","MGI:1925491","basic leucine zipper transcription factor, ATF-like 3; targeted mutation 1, Kenneth M Murphy","Batf3<tm1Kmm>","MGI:3817232","Unknown",{"$nulls":28},"Mice that are homozygous for this allele are viable and fertile. Batf3 is highly expressed in CD11c+ CD8α+ conventional dendritic cells (cDCs), with low to absent expression in other immune cells.The deletion of Batf3 prevents development of splenic CD8α+ cDCs, which are important for cross-presentation during infections. Lymph nodes and thymi of Batf3-/- mice lack CD8α+ DCs, and DCs generated from Batf3-/- bone marrow (BM) and spleens are deficient in Toll-like receptor (TLR) 3-induced interleukin (IL)-12 production. These mice also lack CD103+CD11b- DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Exhibiting defects in CD8+T cell response priming, including lack of virus-specific responses, results in the inability to reject highly immunogenic syngeneic tumors.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-07-19","Cryopreserved sperm",54,0,"ANU",null,"false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":3},"Ian","Cockburn","ian.cockburn@anu.edu.au","N/A","N/A","No"]
[6908,"BAC(A33:M2rtTA)","B6;129-Tg(Gpa33-rtTAS*M2)1",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane), Gpa33","Mosaic activity in intestinal epithelium",{"$nulls":9},"Not described","The M2rtTA tet transactivator is expressed in the epithelium of the intestine and colon under the control of the intestine-specific A33 promoter. The expression/activety of the transactivator is mosaic, most likely due to stochastic transgene silencing. Approximately 1 to 5 crypts in the proximal small intestine express the transgene, fewer in the distral intestine and colon.","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-06-14","Cryopreserved sperm",50,0,"Ludwig","ME-317","true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"015/09","1451/2004","No"]
[2399,null,"MRL/MpJ",null,"Dominant",{"$nulls":37},"The MRL/MpJ mice are large but docile to the point that males rarely fight. Mice submitted to APB for sperm cryopreservation bred as a control for MRL/MpJ-Faslpr, also exhibit autoimmune disorders but symptoms are manifested much later in life compared to those the MRL/MpJ-Fas<lpr> mice. Starting at about three months of age, levels of circulating immune complexes rise greatly in the MRL-Fas<lpr> mouse but not in the wildtype control, MRL/MpJ. Also beginning at 3 months Fas<lpr> mice exhibit very severe proliferative glomerulonephritis, whereas in the MRL/MpJ controls usually only mild glomerular lesions are detected. The MRL/MpJ lymphoproliferation wildtype females die at 73 weeks of age and males at 93 weeks. This compares to a lifespan of 17 weeks in the female and 22 weeks for males in the mouse homozygous for Fas<lpr>. Mice have increased healing ability.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Sib x Sib","Yes","2007-12-20","Cryopreserved sperm",70,0,null,null,"false",null,"Michael","Hickey","Monash University","michael.hickey@med.monash.edu.au",{"$nulls":3},"Michael","Hickey","michael.hickey@med.monash.edu.au","N/A","N/A","No"]
[5107,"Leaden","C57L/JAnuApb",null,"Dominant",{"$nulls":37},"Normal","Normal","C57L/JABS","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-05-03","Cryopreserved sperm",50,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","A.BS.01.09","N/A","No"]
[5618,"B6 CX3 CR1 and C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5619,"B6 ngfr P75",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5620,"B6 ROSA26A-EGFP  ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3498,null,"C57BL/6-Phex<ska1>/Wehi",null,"X-linked","phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)","Phex","Unknown","HPDR1","MGI:107489","skeletal abnormality 1","Phex<Ska1>","MGI:2429767","X",{"$nulls":15},"No",{"$nulls":12},"Hypophosphatemia, skeletal abnormalities consistent with rickets, including increased width of unmineralized epiphyseal growth plate, reduced bone width in the central metaphysis, and increased trabecular bone volume in the proximal metaphysis.  Abnormal angulation of the hips and knees. In all affected mice many bones appeared shorter than in wild-type mice and the vertebrae of affected mice were elliptical. In 30 to 50% of affected hemizygous male mice, heterozygous female mice and homozygous female mice, exostoses on the ribs were also observed. Ten of the 11 bone measurements were significantly shorter in mutant mice and appeared independent of sex. Only the mandible length was not significantly shorter. exostoses in bone from affected animals. Ska1 mice had markedly reduced serum phosphate levels and markedly elevated serum alkaline-phosphatase levels, modest reductions in serum calcium were also observed.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-24",null,0,0,null,"WEHI #817","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[4960,"TNAP-Cre","129-Alpl<tm1(cre)Nagy>/AnuApb",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase",{"$nulls":11},"Perinatal lethal","Normal","129","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-01-12","Cryopreserved sperm",75,0,"ANU",null,"false",null,"Klaus","Matthaei","The Australian National University","klaus.matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5309,"18FOX 010a B6.129-Tg(FoxP3-GFP)","ENU18FOX:010a Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Reduced lymphocyte population / lymphopenia.Phenotype detected by peripheral blood FACS.Cells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-11-08","Cryopreserved sperm",40,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":3},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","N/A","N/A","No"]
[5309,"18FOX 010a B6.129-Tg(FoxP3-GFP)","ENU18FOX:010a Foxp3<tm2Ayr>",null,"Recessive","DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)","Dclre1c",null,"Art, Artemis","MGI:2441769",{"$nulls":3},"2","ENSMUSG00000026648","ENSMUST00000061852","Dclre1c-001","656","743","T to C","ENSMUSE00000319676","8","219","Unknown to Unknown",{"$nulls":4},"TTATGGCTACGAGTATTTATTCACCAACCTAAGCGAGGAGCTGGGAGTTCAGGTTCATGTG","No",{"$nulls":42},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","N/A","N/A"]
[3504,"Trif KO","B6.129-Ticam1<tm1Aki>/Wehi",null,"Recessive","toll-like receptor adaptor molecule 1 ","Ticam1","Unknown","TICAM-1, Trif","MGI:2147032","toll-like receptor adaptor molecule 1; targeted mutation 1, Shizuo Akira ","Ticam1<tm1Aki>","MGI:3029019","17",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal interleukin level* severely impaired production of IL12p40 and partiallyDecreased circulating interleukin-6 level * following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholineDecreased susceptibility to endotoxin shock * mice were resistant to LPS-induced shockDecreased susceptibility to viral infection * following exposure to inactivated H5N1 virus, acute-lung injury and IL6 production are attenuated compared to in wild-type miceAbnormal interleukin level * severely impaired production of IL12p40 and partiallyDecreased circulating interleukin-6 level * following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholineDecreased susceptibility to injury * following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance, edema, and serum IL6 levels* following exposure to 1-palmitoyl-2-arachidonoyl-phosphatidylcholine, lung function is improved and IL6 production is decreased compared to in similarly treated wild-type mice",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-25",null,0,0,null,"WEHI #847","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[323,"NOD-Scid","NOD.CB17-Prkdc<scid>",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, DNPK1, HYRC1, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":12},"Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Homozygotes have severe combined immunodeficiency.No endogenous T- or B- Lymphocyte function. Most homozygotes have no detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Thymus, lymph nodes, and splenic follicles are virtually devoid of lymphocytes (Lymphopenia).  They have hypogammaglobulinemia, and a normal hematopoietic microenvironment. Normal antigen-presenting cell, myeloid, and NK cell functions are strain dependent. Scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. Develops high incidence of thymoma with age.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-05",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":3},"Michael","Hall","Michael.Hall@arc.wa.gov.au","N/A","N/A","No"]
[2449,null,"Pardon",null,"Recessive","cadherin 23 (otocadherin)","Cdh23","Unknown","ahl, ahl1, bob, mdfw, nmf112, nmf181, nmf252, USH1D","MGI:1890219",{"$nulls":3},"10",{"$nulls":15},"No",{"$nulls":12},"Mutant mice exhibit circling behavior, tilting of the head and are deaf.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14",null,0,0,null,null,"true",null,"Shehnaaz","Manji","Murdoch Childrens Research Institute","Shehnaaz.manji@mcri.edu.au",{"$nulls":3},"Shehnaaz","Manji","Shehnaaz.manji@mcri.edu.au","N/A","N/A","No"]
[7050,null,"B6.129P2-Lipe<tm1Rze>/MarpApb",null,"Recessive","lipase, hormone sensitive","Lipe","Unknown","4933403G17Rik, HSL","MGI:96790","lipase, hormone sensitive; targeted mutation 1, Rudolf Zechner","Lipe<tm1Rze>","MGI:2388334","7",{"$nulls":28},"Abnormal lipid level: diglycerides accumulate in brown fat, white fat, testes, skeletal muscle, and cardiac muscle.Abnormal fatty acid level: shift from reduced short chain fatty acids to elevated long chain fatty acids is seen in the white fat.Abnormal triglyceride level:in white fat the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased.Decreased triglyceride level: decreased by about 70% in cardiac muscle compared to controls.Decreased liver triglyceride level:decreased by about 90% compared to controls.Increased triglyceride level: increased by about 30% in brown fat compared to controls.Abnormal metabolism: * decrease in the formation of free fatty acids in white and brown fat, skeletal and cardiac muscle, liver, and brain * reduced capacity for hydrolysis of diglycerides in all tissue examined * reduced capacity for hydrolysis of triglycerides only in white fat and testesAbnormal brown adipose tissue physiology: diglycerides accumulate in brown fatAbnormal white adipose tissue physiology: * diglycerides accumulate in white fat * the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-08-20","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Matthew","Watt","Monash University","matthew.watt@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[1554,null,"BALB/c-Stat6<tm1Aki> Tg(iFABPp-IL9) ",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Unknown",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No","interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",95,0,null,"ABS #041","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[2451,null,"Tsavo",null,"Recessive","transmembrane channel-like gene family 1","Tmc1","Unknown","Beethoven, Bth","MGI:2151016",{"$nulls":3},"19",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice are characterized by progressive degeneration of the cochlear inner hair cells and concomitant deafness. Different alleles causing progressive deafness or profound congenital deafness",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14",null,0,0,null,null,"true",null,"Shehnaaz","Manji","Murdoch Childrens Research Institute","Shehnaaz.manji@mcri.edu.au",{"$nulls":3},"Shehnaaz","Manji","Shehnaaz.manji@mcri.edu.au","N/A","N/A","No"]
[7395,"B6-Lym1","B6.BALB/c-Nfkb2<Lym1>/WehiAnuApb",null,"Recessive","nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100","Nfkb2","Unknown","NF kappaB2, p52","MGI:1099800","nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Lym1","Nfkb2<Lym1>","MGI:4412046","19",{"$nulls":28},"Increased circulating lymphocytes.A comprehensive histopathological analysis of these mice, however, revealed an absence of peripheral LN (inguinal, brachial, axillary, cervical) and Peyer’s patches. Mesenteric LN were present, but were reduced in size and cellularity.presence of inflammatory cell infiltrates in the lung and liver.The number of mature recirculating B cells was significantly reduced.Nfkb2<Lym1/Lym1> bone marrow was almost completely unresponsive to RANKL with osteoclast formation <0.5% of that seen with wt.Mild osteopetrosis, with significantly increased trabecular bone volume","The ability of Nfkb2<Lym1/+> cells to form osteoclasts in response to RANKL stimulation was significantly reduced","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2013-08-12","Cryopreserved sperm",4,0,"ANU",null,"false",null,"Matthew","Cook","The Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[4448,"APN16","B6;129-Dusp4<Gt(XG164)Byg>/MIMR",null,"Recessive","Dual specificity phosphatase 4","Dusp4","Unknown","MKP2","MGI:2442191","dual specificity phosphatase 4; gene trap XG164, BayGenomics","Dusp4<Gt(XG164)Byg>","MGI:4127030","8",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1","0",null,"No","2009-02-20","Cryopreserved sperm",70,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","deborah.bianco@monash.edu","N/A","N/A","No"]
[2454,null,"ENU6PH:043",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":15},"No",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Matt","Cook","matt.cook@anu.edu.au","N/A","N/A","No"]
[3593,null,"C57BL/6.129-Tcra<tm1Mom>",null,"Recessive","T-cell receptor alpha chain","Tcra","Nil","Tcr alpha, Tcralpha","MGI:98553","targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous mice for the Tcra<tm1Mom> targeted mutation are viable and fertile. They are deficient in the alpha beta T-cell receptor. The thymus is devoid of CD4+CD8- and CD4-CD8+ cells. Normal numbers of CD4+CD8+ cells are retained without the IL2 receptor. There are normal numbers of CD4-CD8- cells. ~1% of the thymocytes express the gamma delta TCR. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age. Increased susceptibility to bacterial infection    •  greatly increased susceptibility to infection with Mycobacterium paratuberculosis. Older mice may have digestive system problems including ulcers and diarrhea.   They will have an impaired immune response but should remain healthy under clean conditions ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06",null,0,0,null,"WEHI #1849","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4962,"Ccr1 +/+","129-Ccr1<WT>",null,"Recessive","chemokine (C-C motif) receptor 1","Ccr1","Nil","Cmkbr1, MIP-1 alphaR, Mip-1a-R","MGI:104618",{"$nulls":3},"9",{"$nulls":15},"No",{"$nulls":12},"Normal.Control for Ccr1 knockout mouse.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-13","Cryopreserved sperm",50,0,null,"ABS #193","false",null,"Paul","Foster","The University of Newcastle","paul.foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[2803,"C57BL/6.Max 41","C57BL/6-Tg(IghMAX)41Wehi/Wehi ",null,"Dominant",{"$nulls":25},"human Max","5' intronic enhancer Eu of the immunoglobulin heavy chain locus",{"$nulls":10},"Excess granulocytes, B cell deficiency, thymic lymphoma.Maximal severity of phenotype according to age.Approx. 30% thymic lymphomas at 6-12 wks.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-02-22",null,0,0,null,"WEHI ID#49","true",null,"Donald","Metcalf","Walter and Eliza Hall Institute of Medical Research","metcalf@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5441,"Men1 del/wt (Martin C)","B6.129T2-Men1<tm2.1Gfk>/Apb","B6.129T2-Men1<tm2.1Gfk>","Recessive","multiple endocrine neoplasia 1","Men1","Nil","menin","MGI:1316736","multiple endocrine neoplasia 1; targeted mutation 2.1, Graham F Kay","Men1<tm2.1Gfk>","MGI:3810641","19",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal","Tumours with age predominantly in pancreas, pituitary and parathyroids.","C57BL/6","No","No","Yes","No","No","Yes","No","Good","14","1","heterozygote cross wildtype","No","2011-02-17","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Nicholas","Hayward","Queensland Institute of Medical Research","nick.hayward@qimr.edu.au","300 Herston Road","Brisbane","QLD","Magdalena","Auret","maggieA@qimr.edu.au","A0502-602M","1859-2012","No"]
[3626,null,"B6.129S4-IL2ra<tm1Dw>",null,"Recessive","interleukin 2 receptor, alpha chain","Il2ra","Nil","CD25, IL-2R alpha chain, Il2r, Ly-43","MGI:96549","targeted mutation 1, Dennis M Willerford","Il2ra<tm1Dw>","MGI:1857192","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.",null,"C57BL/6 x 129","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12",null,0,0,null,"WEHI #2111","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":3},"Stephen","Nutt","Stephen","N/A","N/A","No"]
[6913,"ENU23:G1","ANU:ENU23:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm",1398,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[1552,null,"BALB/c-IL4R<tm1> Tg(iFABPp-IL9)",null,"Recessive","interleukin 4 receptor, alpha","Il4ra","Unknown","CD124, IL-4 receptor alpha chain, Il4r","MGI:105367",{"$nulls":3},"7",{"$nulls":15},"Yes","Interleukin 9","rat intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences). ","High",{"$nulls":9},"Restricted expression of IL9 transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",130,0,null,"ABS #039","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[6911,"ENU22:G1","ANU:ENU22:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm",1096,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7409,"Amigo2 KO ; TF3111","B6.129/SvEv-Amigo2<Gt(AI415330)tac>/TacAnuApb",null,"Recessive","adhesion molecule with Ig like domain 2","Amigo2",null,null,"MGI:2145995",{"$nulls":3},"15",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-08-22","Cryopreserved sperm",11,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Carola","Vinuesa","carola.vinuesa@anu.edu.au","A2012/05","11.16","No"]
[7435,"CSTCR","C.B6-Thy1<a> Tg(TcraTcrbYA26)1/QimrAnuApb",null,"Dominant","thymus cell antigen 1, theta","Thy1",null,"CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":16},"tansgene insertion 1, Fidel Zavala",{"$nulls":11},"The mice express a monoclonal TCR specific for SYVPSAEQI in context of H2Kd – these particular mice are backcrossed to Thy1.1",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-09-16","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":3},"Nikki","Ross","nikki.ross@anu.edu.au","A2013/12","13.08","No"]
[4867,"TNAP:Cre ; TC","BALB/c-Alpl<tm1(cre)Nagy> ",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase","TNAP",{"$nulls":10},"Embryonic Lethal",null,"BALB/c x C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-25",null,0,0,null,null,"true",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","R.MG.11.08","N/A","No"]
[3326,"Chop KO","C57BL/6-Ddit3<tm1Mori>/Wehi",null,"Recessive","DNA-damage inducible transcript 3","Ddit3","Nil","C/EBP homoologous protein 10, chop, CHOP-10, CHOP10, gadd153","MGI:109247","targeted mutation 1, Masakata Mori","Ddit3<tm1Mori>","MGI:2179046","10",{"$nulls":15},"Yes",{"$nulls":12},"Original mutant on 129/C57BL/6 background had larger brains. Decrease neuronal apoptosis in vivo and in vitro.On C57BL/6 background: kidney epithelium, macrophages and thymocytes are resistant to ER stress induced apoptosis.Males are aggressive.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het x WT C57BL/6","No","2008-06-15",null,0,0,null,null,"true",null,"Hamsa","Puthalakath","La Trobe University","h.puthalakath@latrobe.edu.au",{"$nulls":3},"Hasma","Puthalakath","h.puthalakath@latrobe.edu.au","N/A","N/A","No"]
[5144,"ENU15CHINA:002","C57BL/6JAnu-Gmds<m1Anu>/AnuApb","C57BL/6JAnu-Gmds<m1Anu>/AnuApb","Recessive","GDP-mannose 4, 6-dehydratase","Gmds",null,null,"MGI:1891112","GDP-mannose 4, 6-dehydratase; mutation 1, The Australian National University","Gmds<m1Anu>","MGI:5563466","13","ENSMUSG00000038372","ENSMUST00000041859","Gmds-001","561","692","T to A","ENSMUSE00000282995","6","187","Tyrosine to STOP",{"$nulls":4},"CCCTATGGAGCAGCCAAACTCTATGCCTATTGGATTGTGGTGAATTTCCGTGAAGCTTATA","Yes",{"$nulls":12},"Highly activated T cells, expansion of myeloid cells.High CD44<+> B and T cells, Low T cells, Low NK cells.","Unknown","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Poor",null,"2",null,"No","2010-05-28","Cryopreserved sperm",53,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[5261,"Col1-EphB4 Tg","C57BL/6-Tg(Col1a1-EphB4)1Mat",null,"Dominant",{"$nulls":25},"Mouse Eph receptor B4","collagen, type I, alpha 1 (Col1a1)","Restricted to osteoblasts",{"$nulls":9},"EphB4 transgenic mice expressed 6.7-fold higher levels of Ephb4 transcripts in calvaria and 4.8-fold higher in the long bones as measured by RT-PCR.EphB4 transgenic mice exhibited increased bone mass by 10 weeks of age.Quantitative bone histomorphometry further showed that bone volume, osteoid thickness, mineralizing surface, and bone formation rate were significantly increased in transgenic mice versus wild-type controls (Figure 7C). Serum levels of osteocalcin, a marker of bone formation, were also slightly elevated in EphB4 transgenic mice.Osteoclast number, osteoclast surface, and eroded surface were significantly reduced in EphB4 transgenic mice compared towild-type controls, indicating that osteoclast function was inhibited in these mice.EphB4 transgenic mice showed a decrease in urinary deoxypyridinoline (DPD) crosslinks, a marker for osteoclastic bone resorption, indicating that osteoclast function was suppressed. Such reduced osteoclastic activity is not due to reduction in RANKL or M-CSF or to an increase in OPG since there was no significant difference in Rankl, Csf1, and Opg mRNA levels in bone or RANKL and OPG levels in serum between wild-type and EphB4 transgenic mice.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-21",null,0,0,null,"336","true",null,"Natalie","Sims","St Vincent's Institute","nsims@svi.edu.au",{"$nulls":3},"Natalie","Sims","nsims@svi.edu.au","N/A","N/A","No"]
[5288,"B6.PAR1.KO","C57BL/6-F2r<tm1Ajc>",null,"Recessive","coagulation factor II (thrombin) receptor","F2r","Nil","Cf2r, Par1, thrombin receptor, ThrR","MGI:101802","coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly","F2r<tm1Ajc>","MGI:1857306","13",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality during organogenesis: * approximately 50% of homozygotes die between E9.0-10.0. * the remaining 50% survive to adulthood and appear grossly normal. * similar frequencies of embryonic lethality are observed in the C57BL/6J and 129/Sv inbred backgrounds.Abnormal cardiovascular system physiology: * at E8.5, homozygotes have beating hearts and a functional vitelline circulation. * by E9.5, approximately half of the mutant embryos display no heart beat.Abnormal cell physiology: notably, in contrast to platelets, homozygous mutant fibroblasts lack thrombin-induced responses.Decreased embryo size: * at E8.5, homozygotes are morphologically indistinguishable from wild-type embryos. * starting at E9.0, mutant embryos become uniformly smaller than wild-type embryos.Abnormal placenta development: at E9.0 and thereafter, homozygotes display a delay in placental development.Embryonic growth retardation: at E9.0 and thereafter, homozygotes display a global developmental delay.Hematopoietic system phenotype: * surviving homozygotes display normal tail bleeding times and no bleeding diathesis relative to wild-type. * in addition, mutant platelets display strong thrombin-induced responses.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #173","true",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","N/A","N/A","No"]
[3339,"cbfa2t3 -/-","C57BL/6-Cbfa2t3<tm1.1DCal>/Apb",null,"Recessive","core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)","cbfa2t3","Nil","ETO-2, MTGR2","MGI:1338013",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"Hom x Hom","Yes","2008-06-20","Cryopreserved sperm",90,0,null,null,"false",null,"David","Callen","Hanson Institute","david.callen@imvs.sa.gov.au",{"$nulls":3},"David","Cullan","david.callen@imvs.sa.gov.au","N/A","N/A","No"]
[7051,"Aire x Met-Kb","STOCK-Aire<tm1> Tg(sMt1-H2-K<b>)",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire",null,null,"MGI:1338803",{"$nulls":3},"10",{"$nulls":16},"mouse H2-K<b> (MHC class I)","Sheep metallothionein promoter","variable and slightly lower than wild type H2-K<b>. Expression can be induced with Zinc",{"$nulls":9},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"No","2012-08-20",null,0,0,null,null,"true",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":6},"N/A","N/A","No"]
[4963,"Sall-GFP","B6.129-Sall1<tm3Ryn>/Apb",null,"Dominant","sal-like 1 (Drosophila)","Sall1","Normal","Msal-3","MGI:1889585","sal-like 1 (Drosophila); targeted mutation 3, Ryuichi Nishinakamura","Sall1<tm3Ryn>","MGI:3603818","8",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal","Normal.GFP labelled Sall1 structures in embryonic kidney.","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2010-01-15","Cryopreserved sperm",72,0,null,null,"false",null,"Melissa","Little","The University of Queensland","m.little@imb.uq.edu.au",{"$nulls":3},"Melissa","Little","m.little@imb.uq.edu.au","IMB/971/08/APA","NLRD 645/2003","No"]
[4967,"B6-HIPCre","B6.NOD-Tg(INS-cre)2Rms/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Robyn M Slattery","human insulin promoter","beta islet cells",{"$nulls":9},"The human insulin promoter (INS) drives cre expression in beta islet cells. Resistance to development of diabetes and hyperglycemia",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-15","Cryopreserved sperm",100,0,"Monash",null,"false",null,"Robyn","Slattery","Monash University","robyn.slattery@monash.edu","Dept Immunology, 2nd floor Monash bldg, Alfred Hospital, Commercial Rd,","Prahran","Victoria","Robyn","Slattery","Robyn.slattery@med.monash.edu.au","N/A","N/A","No"]
[6200,"CD14","B6.129S-CD14<tm1Frm>/J",null,"Recessive","CD14 antigen","Cd14    ","Nil",null,"MGI:88318","CD14 antigen; targeted mutation 1, Mason W Freeman","Cd14<tm1Frm>","MGI:1934009","18",{"$nulls":28},"Pulmonary edema:*Less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation.Abnormal cytokine level:*Keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide.*Macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide.      Abnormal interleukin level:      *Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide.      Abnormal tumor necrosis factor level:      *TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide.Increased bone mineral content:*Greater mineral content.Increased bone mineral densityIncreased bone mass:*Increased bone area of the tibia.Decreased susceptibility to bone fracture:*Bones resistant to fracture.Pulmonary edema:*Less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation.Decreased total body fat amountIncreased lean body mass",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","451","true",null,"Louis","Schofield","Walter and Eliza Hall Institute of Medical Research","schofield@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6204,"IFNg ","B6.129S7-Ifng<tm1Ts>/J ",{"$nulls":3},"  ifng    ",{"$nulls":35},"\"Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a \"\"clean\"\" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.   Increased sensitivity to xenobiotic induced morbidity/mortality Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU)  Increased susceptibility to bacterial infection induced morbidity/mortality Die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459) Increased susceptibility to parasitic infection induced morbidity/mortality Most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts   (MGI Ref ID J:50832) \"",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","4280","true",null,"Doug","Hilton",{"$nulls":8},"N/A","N/A","No"]
[6915,"ENU25:G2","ANU:ENU25:G2",null,"Recessive",{"$nulls":37},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2012-06-22","Cryopreserved sperm",1438,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6914,"ENU25:G1","ANU:ENU25:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm",497,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6912,"ENU24:G1","ANU:ENU24:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6Crl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-06-22","Cryopreserved sperm",471,26,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[844,"SW{HEL}-L ; LC2 Ig","C57BL/6-Tg(IgkHyHEL10)1Rbr",null,"Dominant",{"$nulls":25},"transgene insertion 1, Robert Brink",{"$nulls":11},"B cells express immunoglobulin light chain that recognises hen egg lysozyme.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-23",null,0,0,null,null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[3407,"MHCII I-A<b> o/o","B6.129-H2-Ab1<tm1Doi>/Wehi",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Nil","A beta, Abeta, H-2Ab, H2-Ab, I-A<b>, I-Abeta, Ia-2, Ia2, IAb, Rmcs1","MGI:103070","histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis","H2-Ab1<tm1Doi>","MGI:1927483","17",{"$nulls":15},"Yes",{"$nulls":12},"MHC II-deficient mice do not develop CD4 (helper) T cells. This results in impaired cellular and antibody mediated immune responses. Mice do not appear different to C57BL/6 mice when housed in a clean environment.  IA/IA mice seem to breed more robustly when first mated at an older age (12 weeks) rather than the standard 8 weeks (observation G. Davey)",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13",null,0,0,"WEHI","102","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7467,"Bm1.OT-1","B6.C-H2<bm1> Tg(TcraTcrb)1100Mjb/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1100, Michael J Bevan","H-2K<b> promoter",null,"histocompatibility 2, K region","H2-K",null,null,"MGI:3040519","histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17","Transgenic mice on a C57BL/6 background are somewhat immunodeficient, and may be used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen.Carry OVA-specific, H-2K<b>-restricted T cell receptor","Normal","B6.C-H2<bm1>/ByJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2013-10-29","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":3},"Patrick","Bertolino","p.bertolino@centenary.org.au","Bertolino 2013/013 (Royal Prince Alfred Hospital AEC)","IBC 02-0025 / OGTR 536-2002 / PC1NLRD ","No"]
[7450,"Lifr fl","B6NTac;B6N-Lifr<tm1a(EUCOMM)Hmgu>/HTacAnuApb",null,"Dominant","leukemia inhibitory factor receptor","Lifr","Normal","A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788","leukemia inhibitory factor receptor; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Lifr<tm1a(EUCOMM)Hmgu>","MGI:4841519","15",{"$nulls":28},"Normal",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-10-04","Cryopreserved sperm",75,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"A2012/05","N/A","No"]
[5617,"B57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3418,"Max.OT-1 transgenic","C57BL/6-Tg(TcraTcrb)1100Mjb Tg(IghMAX)Wehi/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1100, Michael J Bevan",{"$nulls":11},"TCR transgenics are immunocompromised by having a mono-specific T cell receptor however, in a clean envirnoment, mice show no difference in phenoptype from wild-type B6 mice.  Max.OT-I T cells are highly diabetogenic when transferred into RIP-mOVA mice.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14",null,0,0,null,"WEHI #136","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[{"$nulls":30},"human Max","5' intronic enhancer Eu of the immunoglobulin heavy chain locus"]
[6231,"Bak/vavbcl69","B6.129-Bak1<tm1Thsn> Tg(Vav-BCL2)1Jad",null,"Semi-dominant","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":16},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","Overexpression",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1808","true",null,"Suzanne","Cory","Walter and Eliza Hall Institute of Medical Research","cory@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5622,"B6;129P2-Omp<tm(cre)Mom>MomJ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6234,"Bax/Bmf","B6.129-Bax<tm1Sjk> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":28},"Male sterility in -/-. Otherwise, grossly normal. Most -/- mice have grey fur compared to +/- and +/+ which are black.  Double -/- males should be infertile.",null,"129/Sv","Yes","Unknown","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2283","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6234,"Bax/Bmf","B6.129-Bax<tm1Sjk> Bmf<tm1Rjd>",null,"Recessive","BCL2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7",{"$nulls":61},"N/A","N/A"]
[6805,"tenascin C KO","129/Sv-Tnc<tm1Ref>/MelbApb",null,"Recessive","tenascin C","Tnc","Nil","C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C","MGI:101922","tenascin C; targeted mutation 1, Reinhard Fassler","Tnc<tm1Ref>","MGI:2148541","4",{"$nulls":28},"No abnormal phenotype.","No abnormal phenotype.","129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-01-31","Cryopreserved sperm",50,0,null,null,"false",null,"Eleanor","Mackie","The University of Melbourne","ejmackie@unimelb.edu.au",{"$nulls":3},"Charles","Pagel","cpagel@unimelb.edu.au","N/A","N/A","No"]
[4799,"Dimit; ENU13NIH:039ab","C57BL/6JAnu-Ighd<dmit>/AnuApb","C57BL/6JAnu-Ighd<dmit>/AnuApb","Recessive","immunoglobulin heavy constant delta","Ighd","Unknown","IgD","MGI:96447","dimit","Ighd<dmit>","MGI:4819235","12","ENSMUSG00000076616","ENSMUST00000103424","Igh-5-201","241","241","T to A","ENSMUSE00000663372","1","74","Isoleucine to Lysine",{"$nulls":4},"CAGAACTGAACCTCAACCACACTTGCACCATAAATAAACCCAAAAGGAAAGAAAAACCTTT","Yes",{"$nulls":12},"Shifted IgD expression measured by flow cytometry",null,"C57BL/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-10","Cryopreserved sperm",37,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","J.APF.21.08","N/A","Yes"]
[4588,"Seshat ; ENU11B6:169b","C57BL/6JAnu-Cd4<sesh>/AnuApb","C57BL/6JAnu-Cd4<sesh>/AnuApb","Recessive","CD4 antigen","Cd4","Unknown","L3T4, Ly-4","MGI:88335","seshat","Cd4<sesh>","MGI:4819228","6","ENSMUSG00000023274","ENSMUST00000024044","Cd4-001","374","543","T to C","ENSMUSE00000246632","4","125","Valine to Alanine",{"$nulls":4},"GAACAGGAAAGAGGAGGTGGAGTTGTGGGTGTTCAAAGTGACCTTCAGTCCGGGTACCAGC","Yes",{"$nulls":12},"Reduced T cell numbers in peripheral blood. Reduced CD4 expression.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-11","Cryopreserved sperm",97,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","J.APF.14.08","N/A","No"]
[3624,null,"B6.CBA-Tg(Pou5f1-EGFP)",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Enhanced green fluorescent protein (GFP)","Pou domain, class 5, transcription factor 1 (Pou5f1)",{"$nulls":10},"Expression of GFP in primordial germ cells",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-12",null,0,0,null,"WEHI #2089","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hamish.scott@imvs.sa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[6256,"CBA.nu","CBA-Foxn1<nu>/Wehi",null,"Recessive","forkhead box N1","Foxn1","Nil","D11Bhm185e, Hfh11, whn","MGI:102949","forkhead box N1; nude ","Foxn1<nu>","MGI:1856108","11",{"$nulls":28},"Partial postnatal lethality:*Some mice die within 1 week of birth*55% mortality within 2 weeksPremature death:*100% mortality by 25 weeksSmall ovaryDecreased body size      Decreased body weightPostnatal growth retardationAbnormal liver morphology:*Liver lobes were atrophied and covered with red scars.*Variable degrees of severity, typically increasing with age at time of death.Coiled sperm flagellum:*Many sperm had coiled tails.Abnormal estrous cycle:*Many females exhibited continuous dioestrus and metaoestrus phasesFemale infertility:*Severely reduced fertility.Reduced male fertilityAsthenozoospermiaDecreased leukocyte cell numberAthymiaHairless*Sparse hair growth around 5 weeks of age.*In some mice, cephalo-caudal migration of an irregular band of short sparse hair.Absent vibrissae:*Absent at birth.Short vibrissae:*Older mice show repeated growth and loss of short and wavy vibrissae.Wavy vibrissae:*Older mice show repeated growth and loss of short and wavy vibrissae.Thin skin:*Reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin.",null,"CBA","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","938","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5158,"4AT22 ; ANNA","ENU4AT:022",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Anti-nuclear antibodies, high.Both young and older mice.","Normal","C57BL/6 x B10BR X CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-06-25","Cryopreserved sperm",15,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":6},"J.IG.31.04","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[6917,"FVBNJ-Momme D35","FVB/NJ-Smarca5<MommeD35> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5","Smarca5",null,null,"MGI:1935129",{"$nulls":3},"8",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of enhancer region","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm",39,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","P1224","No"]
[1823,"MHC II-EGFP","C57BL/6-Tg(MHCII-EGFP)",null,"Dominant",{"$nulls":25},"MHC class II tagged with Green fluorescent Protein",{"$nulls":11},"Normal.MHC II positive cells are fluorescent (EGFP+).Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #1045","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadengos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5417,"A33:Lgp130YFKO ; line 6 backcross (ME-248)","CB;129-Tg(Gpa33-Il6st*)6Ern/Lud",null,"Dominant",{"$nulls":26},"glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-02-04","Cryopreserved sperm",50,0,"Ludwig","ME-248","true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"019/09","040/2001 & 304","No"]
[6257,"CD40K","B6.129P2-Cd40<tm1Kik>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","CD40 antigen; targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":28},"Hematopoietic system phenotype*Normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles.Abnormal dendritic cell physiology:*Impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7.*Impaired priming of IFN-gamma producing T cells.Increased susceptibility to bacterial infection:*Increased susceptibility to aerosol Mycobacterium tuberculosis infection.*Increased bacterial loads in lung and spleen.*40% of infected mice moribund 3 - 4 weeks postinfection.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","137","true",null,"Andrew","Lew","Walter and Eliza Hall Institute of Medical Research","lew@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6270,"ERTF5/TOM","ERTF5-rttA3-GFP/Tet-O c-myc",{"$nulls":3}," ERTF5TA    c-myc   ",{"$nulls":35},"Contact Researcher  This strain carries the human c-myc gene and the rttA3-IRES-GFP cassette which are controlled by the Tet/O and the ERTF5 promoter respectively.   The expression of myc is induced in ERTF5 expressing cells only in the presence of doxycycline.   No Special monitoring required (This stain should not have any obvious phenotype without treatment of doxycycline.)  DOX - The phenotypes of this strain with treatment of doxycycline remain unknown. But this strain may potentially develop tumors in certain tissues upon treatment with doxycycline. ",null,"FVB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3983","true",null,"Jane","Visvader",{"$nulls":8},"N/A","N/A","No"]
[4848,"Lenie","ENU6AT:32",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",30,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5621,"B6 ROSAeGFPxCol1a2 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6918,"FVBNJ-Momme D36","FVB/NJ-Smchd1<MommeD36> Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","SMC hinge domain containing 1","Smchd1",null,"4931400A14Rik, mKIAA0650, MommeD1","MGI:1921605","SMC hinge domain containing 1; modifiers of murine metastable epiallele D36","Smchd1<MommeD36>",null,"17",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of enhancer region","36 copies",{"$nulls":9},"Lethal","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm",40,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","P1224","No"]
[7457,"C2(129)","129X1-Cited2<tm1Jpmb>/VccriApb","129X1-Cited2<tm1Jpmb>","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Nil","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1, Juan Pedro Martinez Barbera","Cited2<tm1Jpmb>","MGI:2176158","10",{"$nulls":15},"No",{"$nulls":12},"Embryos die during gestation (~E15.5). Heart, left-right axis, neural tube, adrenal gland and placental defects.","None","129X1","No","No","Yes","No","No","Yes","No","Good","10","0","C2B6∆ +/- (heterozygous) mated with 129X1","No","2013-10-22","Cryopreserved sperm",50,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au","Lowy Packer Building, 405 Liverpool St","Darlinghurst","Vic","Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","12/33","N21/2012","No"]
[40,"Flipper","B6;NODAnu-Chkb<flp>/AnuApb","B6;NODAnu-Chkb<flp>/AnuApb","Recessive","choline kinase beta","Chkb","Unknown","Chetk, Chkl, CK/EK-beta","MGI:1328313","flipper","Chkb<flp>","MGI:3847123","15","ENSMUSG00000022617","ENSMUST00000023289","Chkb-201","1","1","A to T","ENSMUSE00000322690","1","1","Methionine to Leucine",{"$nulls":4},"ATGGCGGCAGACGGGACAGGGGTAGTCGGAGG","No",{"$nulls":12},"Homozygotes develop shortened and lateral rotation (valgus?) of radius and ulna leading to short and splayed forelegs. Female homozygotes can breed. Male homozygotes die suddenly during mating with haemorrhages in seminiferous glands (this is currently being re-investigated). Some homozygotes also develop perineal hernias.Chkb<rmd> Homozygous null mice display progressive muscular weakness and dystrophy in the hindlimbs but have normal nerve and neuromuscular junction morphology.",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",70,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[7480,"PbT-I-25/Ly5.1 ; C57BL/6-Tg(TCRaB4-46TcrbB4-46)25Cbn","C57BL/6-Ptprc<a> Tg(H2-K<b>-Tcra,-Tcrb)25Cbn/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 25, Francis Carbone","H-2Kb",null,"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","Majority of CD8 T cells express the transgenic T cell recepter Va8Vb10 specific for Plasmodium berghei (Pb) parasites.","As for homozygous","C57BL/6","Yes","Yes","Yes","Unknown","Unknown","Unknown","No","Excellent",null,"4","brother-sister","No","2013-11-14","Cryopreserved sperm",21,0,"ANU",null,"false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":6},"A2013/12","13/08","Yes"]
[5625,"B6.126Tg(myh6-cre/Ers1)1Jmk/J Cardiac Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[2444,"Lightning ; ENU8B6:045","C57BL/6-Ptprc<ltng>/AnuApb","C57BL/6-Ptprc<ltng>/Apb","Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; lightening","Ptprc<ltng>","MGI:4441612","1","ENSMUSG00000026395","ENSMUST00000027645","Ptprc-201","1583","1681","T to C","ENSMUSE00000595907","14","528","Phenylalanine to Serine",{"$nulls":4},"TACAAAATACAACAAGACAAACTGTCAGTTTTATGTAGATAATCTCTACTATTCAACTGAC","No",{"$nulls":12},"Homozygous null mutants have defective T-cell maturation.Decreased CD4-positive T cell number: SP4 thymocytes are reduced compared to in wild-type mice.Abnormal T cell differentiation: * mice exhibit enhanced negative selection compared with wild-type mice. * positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc<tm1Mak> homozygotes.Decreased double-positive T cell number.Thymus hypoplasia.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-14","Cryopreserved sperm",39,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[3423,"RIP-EYFPss","C57BL/6-Tg(Ins2-EYFP/OVA{257-264}/gB{498-505})/Wehi",null,"Dominant",{"$nulls":25},"yellow fluorescent protein (YFP) linked to two class I epitopes: one from OVA (OVA{257–264}) and one from Herpes simplex virus-1 glycoprotein B (gB{498–505})","Rat insulin 2",{"$nulls":10},"Transgenic mice expressing a hybrid fusion protein under the control of the rat insulin promoter (RIP). This hybrid protein consists of yellow fluorescent protein (YFP) linked to two class I epitopes: one from OVA (OVA257–264) and one from Herpes simplex virus-1 glycoprotein B (gB498–505). The hybrid protein is referred to as YSS and the transgenic line RIP-YSS. YSS was expressed only in Pancreas.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15",null,0,0,null,"WEHI #144, 397","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3447,"SOCS-1 (SOCS box) KO clone 311 (SOCS-1ΔSB)","C57BL/6-Socs1<tm2Wehi>/Wehi",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Normal","cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 2, Walter and Eliza Hall Institute of Medical Research","Socs1<tm2Wehi>","MGI:2177057","16",{"$nulls":15},"Yes",{"$nulls":12},"The SOCS box is a C-terminal domain shared with over 30 other proteins that links SOCS proteins to an E3 ubiquitin ligase activity and the proteasome. Mice have an increased responsiveness to IFN-\u0001 and slowly develop a fatal inflammatory disease.Homozygous \u0005\u0001\u0005 mice (SOCS-1ΔSB) were healthy at birth but died prematurely compared with \u0005\u0001\u0004 or wild-type animals. However,the onset of disease was prolonged compared with SOCS-1\u0001-/-\u0001 mice, and it most closely matched that seen previously for SOCS-1\u0001-/-/\u0001IFN-γ-\u0001-\u0004/\u0001 mice. In fact, the predominant disease states seen in \u0005\u0001\u0005SOCS-1ΔSB mice were remarkably similar in frequency and type to those of moribund SOCS-1\u0001-/- \u0001IFN-γ-\u0001\u0004/-\u0001 mice of the same age. Body weight was reduced and extensive inflammatory lesions were seen in skeletal and heart muscle, as well as in the cornea, sometimes with corneal ulceration. The infiltrating cells were predominantly lymphoid cells and macrophages, but the damage to muscle cells was often more severe than that seen in SOCS-1\u0001-/-\u0001IFN-γ-\u0001\u0004/-\u0001 mice. In addition, lymphoid foci were observed in the salivary glands, lungs, and kidneys of \u0005\u0001\u0005mice, and the ratio of granulocytes to mononuclear (lymphoid and erythroid) cells was elevated in the bone marrow. Like SOCS-1\u0001-/-\u0001 mice, \u0005\u0001\u0005 SOCS-1ΔSB mice showed atrophy and dispersion of pancreatic acinar tissue with lymphoid and macrophage infiltration of both the pancreas and dermis and atrophy or thinning of the thymic cortex. Although liver cells did not show fatty degeneration typical of SOCS-1\u0001-/-\u0001 mice, there were areas where the liver trabeculae were thin and widely separated, suggesting previous damage to hepatocytes. This phenotype suggested that SOCS-1\u0001\u0005/ΔSB acted as a partial loss of function mutant with significantly reduced capacity to inhibit responses to endogenous IFN-\u0001γ.Premature death: mice start dying around weaning age with 80% of mice dead by 80 days of age.Decreased body weight: weights drop as mice develop inflammatory disease.Absent spleen germinal center: 55% of mice have no germinal centers in the spleen.Thymus atrophy: is observed in 95% of mice.Increased inflammatory response: mice die from massive generalized inflammation that affects multiple organs.Myocarditis: 90% of mice have inflammation in heart muscle.Pancreas inflammation: is observed in 55% of mice.Salivary gland inflammation: is observed in 61% of mice.Intestinal inflammation: 15% of mice have GI inflammation.Increased incidence of corneal inflammation: is observed in 53% of mice with 16% of mice having inflammatory ulcers.Glomerulonephritis: is observed in 15% of mice th 5% of mice having polycystic disease and 5% necrosis.Liver inflammation: is observed in 35-40% of mice.Muscle inflammation: 90% of mice have inflammation in skeletal muscle.Skin inflammation: is observed in 50% of mice.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2008-07-17",null,0,0,null,"WEHI #414","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7267,"Tuara","CBA-Stat1<m2Anu>/AnuApb",null,"Recessive","signal transducer and activator of transcription 1","Stat1","Unknown",null,"MGI:103063",{"$nulls":3},"1",{"$nulls":28},"Unknown",null,"CBA","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-01-29","Cryopreserved sperm",50,0,"ANU","484","true",null,"Mario","Lobigs","The Australian National University","mario.lobigs@anu.edu.au",{"$nulls":3},"Shelley","Bolton","Shelley.Bolton@anu.edu.au","N/A","N/A","No"]
[8355,"Srsf3-UbcCreERT2-RFP","C57BL/6N-Srsf3<tm1a(KOMP)Mbp> Tg(UBC-cre/ERT2)1Ejb Tg(RFP)/Apb",null,"Recessive","serine/arginine-rich splicing factor 3","Srsf3",null,"Sfrs3, X16","MGI:98285","serine/arginine-rich splicing factor 3; targeted mutation 1a, Mouse Biology Program, UCDavis","Srsf3<tm1a(KOMP)Mbp>","MGI:4462527","17",{"$nulls":16},"transgene insertion 1, Eric J Brown","human ubiquitin C ",{"$nulls":10},"Constitutive expression of RFP, tamoxifen inducible Srsf3 knockout, no phenotype until induced.","See above","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm",50,0,null,null,"true",null,"Minna-Liisa","Anko","Monash University","minni.anko@monash.edu",{"$nulls":8},"No"]
[{"$nulls":30},"Red Fluorescence Protein"]
[5623,"B6;129S5-Shc1tm1lex/Mmnc - incomplete ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7038,"zeta-C57BL/6 390","B6;129-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Poor","N/A",null,"het x het","No","2012-08-06","Cryopreserved sperm",80,0,null,null,"false",null,"Angel","Lopez","SA Pathology","Angel.lopez@health.sa.gov.au",{"$nulls":3},"Hayley","Ramshaw","hayley.ramshaw@health.sa.gov.au","M/236/11","13/2002","No"]
[4976,"ENU14:G1 ; Chokerre","ENU14China:014",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Embryonic lethal.E14 embryos are alive but look sick.Increase in primitive RBCDecrease in definitive RBC","Possible embryonic blood defect","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm",10,0,null,null,"true",null,"Andrew","Perkins","The University of Queensland","a.perkins@imb.uq.edu.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","J.APF.13.08","N/A","No"]
[5757,"Emx2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5544,"ENU18NIH:064a","C57BL/6JAnu-Dock2<m2Anu>/AnuApb","C57BL/6JAnu-Dock2<m2Anu>/AnuApb","Recessive","dedicator of cyto-kinesis 2","Dock2 ","Unknown","CED-5, Hch, MBC ","MGI:2149010","dedicator of cyto-kinesis 2; mutation 2, The Australian National University","Dock2<m2Anu>","MGI:5563490","11","ENSMUSG00000020143","ENSMUST00000093193","Dock2-001","4311","4380","T to A","ENSMUSE00000376674","43","1437","Tyrosine to STOP",{"$nulls":4},"CAGATCATAAACTTTTACAAGTCTAATTATGTGCAAAAGTTCCACTACTCCAGGCCTGTGC",{"$nulls":13},"Reduced numbers of mature B cells in peripheral blood; reduced numbers of T cells in peripheral blood with increased expression of CD44 protein on CD4<+> and CD8<+> cells.","Unknown","C57BL6/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-07-27","Cryopreserved sperm",36,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Heather","Domaschenz","heather.domaschenz@anu.edu.au","J.APF.16.08","N/A","Yes"]
[4706,"OT1xB6Ly5a","C57BL/6-Ptprc<a> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Cd45, Ly-5, Lyt-4, T200","MGI:97810",null,"Ptprc<a>",null,"1",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",25,0,"ANU",null,"false",null,"Edward","Bertram","The Australian National University","edward.bertram@anu.edu.au",{"$nulls":3},"Edward","Bertram","edward.bertram@anu.edu.au","N/A","N/A","No"]
[5634,"Bat Gal",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6919,"FVBNJ-Momme D17","FVB/NJ-MommeD17 Tg(BA1-Gfp)3Ew/Apb",null,"Semi-dominant","Unknown","unknown",{"$nulls":6},"3",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter (-570 to +37) and 4.1kb of  enhancer region","36 copies",{"$nulls":9},"Lethal.Transgene expressed in red blood cells. Percentage of cells expressing GFP transgene is increased in Momme D17. ","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm",19,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","P1224","No"]
[7056,null,"B6;SWR-Clcn1<adr-mto>",null,"Recessive","chloride channel 1","Clcn1","Unknown","Clc1, Clc-1, nmf310, nmf355, NMF355, SMCC1","MGI:88417","chloride channel 1; myotonia","Clcn1<adr-mto>","MGI:1855953","6",{"$nulls":28},"Altered righting response: mice exhibit an arrested development of righting responseAbnormal voluntary movement: * mice exhibit stiffening of hindlimbs when supine with difficulty righting and stiffening of hindlimbs after rapid movement * abnormal phenotype is visible at 2 weeks of age and is progressive * at 2 weeks of age, mice exhibit stiff extensor postures of the limbs when gently dropped from a height of about 10 cm * when tested after 2 hours at 5 degrees Celsius, extensor posture is elicited more easily and its duration is increased by 50% * unlike in wild-type mice, scratching motion with hindlimb is not rapid * when place in an ice water bath mice exhibit a stiff extensor posture of the hindlimbs that is most prominent in the first minute and gradually subsides.Impaired limb coordination: mice are capable of swimming but alternate movements of the hindlimbs are not well coordinated.Abnormal gait: mice exhibit a slightly stiff gait and walk slower than wild-type mice.Muscle phenotype: mice do not display muscle fiber necrosis, grouped atrophy or inflammatory infiltratesIncreased skeletal muscle mass: by day 70, mice exhibit increased muscle bulk in the neck and shoulder girdle muscles compared to wild-type mice.Abnormal muscle physiology: percussion of muscles occasionally produces a sustained local contraction with sustained posturinghowever, muscle weakness is not observed.Abnormal muscle electrophysiology:  * mice exhibit myotonic discharges in limbs, abdominal, tongue, and eye muscles. * unlike in wild-type mice, myotonic discharges are detected from anesthetized mice whose muscles are percussed or stretched * unlike in wild-type mice, myotonic discharges continue for several minutes after amputation.Impaired muscle relaxation: mice exhibit myotoniaAxon degeneration: * by 225 days, mice exhibit degeneration of myelinated axons in the ventrolateral funiculus at all levels of the spinal cord. * however, nerve roots and mixed peripheral nerves are not affectedDecreased body weight: at 30 days mice weigh 10% less than wild-type mice and this difference increases to 40% in adulthood.Reduced fertility: mice are not reliable breeders.Kyphosis: * Background Sensitivity: mice usually develop mild dorsal kyphosis on a mixed background * at day 80, mice exhibit thoracic kyphosis at the T3 to T5 level.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-08-21",null,0,0,null,null,"true",null,"Brett","Cromer","RMIT","brett.cromer@RMIT.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3469,"Cystatin KO","B6.129-Cst3<tm1Karl>/Wehi",null,"Recessive","cystatin C","Cst3","Unknown","CysC, cystatin C","MGI:102519","targeted mutation 1, S Karlsson","Cst3<tm1Karl>","MGI:2182140","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #470","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4974,"C151 CD9 DKO","C57BL/6-CD151<tm1Lka> CD9<Bcx>",null,"Recessive","Cd151 antigen","Cd151","Nil","PETA-3, SFA-1, Tspan24","MGI:1096360","targeted mutation 1, Leonie K Ashman","Cd151<tm1Lka>","MGI:3050539","7",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm",60,0,null,null,"true",null,"Leonie","Ashman","The University of Newcastle","leonie.ashman@newcastle.edu.au",{"$nulls":3},"Leonie","Ashman","leonie.Ashman@newcastle.edu.au","N/A","N/A","No"]
[4974,"C151 CD9 DKO","C57BL/6-CD151<tm1Lka> CD9<Bcx>",null,"Recessive","CD19 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<Bcx>","MGI:2180795","6",{"$nulls":58},"Leonie","Ashman","leonie.Ashman@newcastle.edu.au","N/A","N/A"]
[5112,"las vegas ; ENU7B6:142","C57BL/6JSfdAnu-Tnfaip3<las>/AnuApb","C57BL/6JSfdAnu-Tnfaip3<las>/AnuApb","Recessive","tumor necrosis factor, alpha-induced protein 3","Tnfaip3","Unknown","A20, Tnfip3, zinc finger protein A20","MGI:1196377","tumor necrosis factor, alpha-induced protein 3; las vegas","Tnfaip3<las>","MGI:5563400","10","ENSMUSG00000019850","ENSMUST00000105527","Tnfaip3-002","974","1162","T to A","ENSMUSE00000098571","5","325","Isoleucine to Asparagine",{"$nulls":4},"AGGCTGGGACCACGGCACGACTCACCTGATCAACGCTGCAAAATTGGATGAAGCTAACTTA","Yes",{"$nulls":12},"Increased myeloid cells, lower % lymphocytes, increased % ofCD44<hi> expressing activated/memory T cells",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-10","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6920,"FVBNJ-Momme D13","FVB/NJ-MommeD13 Tg(HBA1-Gfp)3Ew/Apb",null,"Semi-dominant","Unknown","Unknown","Unknown",{"$nulls":5},"3",{"$nulls":16},"transgene insertion 3, Emma Whitelaw","Human alpha-globin promoter and enhancer region","36 copies",{"$nulls":9},"Lethal.Transgene expressed in red blood cells. Percentage of cells expressing GFP transgene is increased in Momme D13.","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2012-06-25","Cryopreserved sperm",19,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","P1224","No"]
[5637,"BDNF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7045,"Activin BK transgenic ; Inhba BKBK","B6.129S7-Inhba<tm2Zuk>/MarpApb",null,"Dominant","inhibin beta-A","Inhba",null,"activin","MGI:96570","inhibin beta-A; targeted mutation 2, Martin M Matzuk","Inhba<tm2Zuk>","MGI:2386671","13",{"$nulls":28},"Mice are viable, but manifest poor overall health at 7 weeks of age","Normal","C57BL/6 x 129S","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","Unknown",null,"Homozygous matings","No","2012-08-06","Cryopreserved sperm",40,0,"Monash",null,"false",null,"Kate","Loveland","Monash University","kate.loveland@monash.edu",{"$nulls":3},"Kate","Loveland","kate.loveland@monash.edu","SOBSB/B/2009/68","PC1-N22-10","No"]
[4978,"ENU11B6:108b","C57BL/6JAnu-Morc3<m1Anu>/AnuApb",null,"Recessive","microrchidia 3","Morc3","Unknown",null,"MGI:2136841",{"$nulls":3},"16","ENSMUSG00000039456","ENSMUST00000044068","Morc3-201",{"$nulls":7},"93860848","10",null,null,"TAAACTTGCCAGTCGAAGACATACAGTAAGTACTGAGCACTGAATTTTGACATACCGTTA","Yes",{"$nulls":12},"High expression of Ly6c in peripheral blood.Maturation defect in NK cells.","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm",40,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Carla","Roots","carla.roots@anu.edu.au","J.APF.13.08","N/A","No"]
[3473,"Socs3 - Socs Box del","C57BL/6-Socs3<tm1Robb>/Wehi",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Unknown","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 1, Lorraine Robb","Socs3<tm1Robb>","MGI:3835162","11",{"$nulls":15},"Yes",{"$nulls":12},"Normal.  Treatment of the mice with pharmacologic doses of G-CSF, which mimics emergency granulopoiesis and therapeutic use of G-CSF, revealed that SOCS3(Delta SB/Delta SB) mice were hyperresponsive to G-CSF. Compared with wild-type mice, SOCS3(Delta SB/Delta SB) mice developed a more florid arthritis when tested using an acute disease model. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #493","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[7626,null,"C57BL/6NCrlAnu-Zfp831<m1Anu>/Apb",null,"Recessive","zinc finger protein 831","Zfp831","Unknown","ENSMUSG00000050600, OTTMUSG00000017459","MGI:3641861","mutation 1, The Australian National University","Zfp831<m1Anu>",null,"2","ENSMUSG00000050600","ENSMUST00000059452","Zfp831-001","2752","2752","T to C","ENSMUSE00000357407","1","918","Tyrosine to Histidine",{"$nulls":4},"CTCGGTCAGGTGGCTTCTTTCCTCCCAAGTACCTCCTCAGGTTACCTCAGGGAGAGAACCC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-03-30","Cryopreserved sperm",22,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[1542,null,"C57BL/6-Gzmb<tm1Ley> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb",null,"Recessive","granzyme B","Gzmb","Unknown","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06",null,0,0,null,"ABS #008","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1542,null,"C57BL/6-Gzmb<tm1Ley> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Unknown","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","Unknown",{"$nulls":61},"N/A","N/A"]
[5558,"Caspase-1 KO","B6;129S2-Casp1<tm1Sesh>/AnuApb",null,"Recessive","caspase 1","Casp1","Nil","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544","caspase 1; targeted mutation 1, Tara Seshadri","Casp1<tm1Sesh>","MGI:1927822","9",{"$nulls":28},"Cellular phenotype: * macrophages and thymocytes from mutant mice retain their capacity to undergo apoptosis upon ex vivo stimulation by several different signals. * in response to ATP, mutant peritoneal macrophages undergo normal apoptosis relative to wild-type. * in response to dexamethasone, aging or gamma irradiation, thymocytes from young homozygotes undergo normal apoptosis relative to wild-type. * in response to LPS and D-galactosamine, homozygotes undergo normal TNF-induced hepatocyte apoptosis and show normal kinetics of death from hepatic failure relative to wild-type mice.Abnormal apoptosis: * mutant peripheral blood neutrophils display retarded constitutive apoptosis relative to wild-type neutrophils * mutant peripheral blood neutrophils show no LPS-mediated inhibition of apoptosis but remain susceptible to Fas-mediated apoptosis.Abnormal cell migration: in homozygotes lacking bioactive IL-1beta, IL-18 fails to induce the expected migration of epidermal Langerhans cells to draining lymph nodes following skin sensitization; as a result, immunostimulatory dendritic cells fail to accumulate in regional lymph nodes resulting in impaired initiation of cutaneous immune responses.Hematopoietic system phenotype: * homozygotes exhibit normal numbers of leukocytes, erythrocytes, and platelets in peripheral blood * freshly isolated mutant thymuses, spleens and lymph nodes contain a normal % of various T cell subsets and B cells relative to wild-type.Immune system phenotype: * in homozygotes, the % of B lymphocytes and the various T lymphocyte subsets found in mutant thymuses, spleens and lymph nodes appear unaffected relative to wild-type. * the size and lymphocyte counts in these lymphoid organs appear normal; myeolopoiesis remains unaffected.Decreased circulating interleukin-1 alpha level: LPS-treated mice show a 5-fold decrease in IL-1alpha levels in vivo.Decreased circulating interleukin-1 beta level: in vivo, homozygous males injected with a high dose of LPS display undetectable levels of mature IL-1beta in their plasma; females are slightly less affected.Decreased circulating interleukin-6 level: after injection with a high dose of LPS, homozygotes display a moderate reduction in IL-6 levels relative to wild-type mice.Decreased circulating tumor necrosis factor level: after injection with a high dose of LPS, homozygotes display a moderate reduction in TNF levels relative to wild-type mice.Abnormal macrophage physiology: ex vivo, thioglycollate-elicited peritoneal macrophages stimulated with LPS and ATP are defective in IL-1beta processing and release.Abnormal neutrophil physiology: * in addition to delayed apoptosis, mutant neutrophils show absence of LPS-stimulated IL-1beta production relative to wild-type. * in response to LPS-mediated acute lung injury, homozygotes show significantly increased total and percent neutrophil counts at 24 and 48 h; however, these numbers decline to wild-type levels by 72 h suggesting a delay in inflammatory neutrophil apoptosis.Decreased T cell apoptosis: in vitro, thymocytes from young homozygotes are resistant to Fas-induced apoptosis as measured by cell viability.Decreased interleukin-1 alpha secretion: surprisingly, homozygous males are also defective in IL-1alpha production, with macrophages releasing only 20-25% of wild-type IL-1alpha levels after stimulation with LPS and ATP ex vivo.Decreased interleukin-1 beta secretion: * homozygotes are impaired in their capacity to produce mature IL-1beta. * ex vivo, mutant peritoneal macrophages stimulated with LPS and ATP release less that 1% of wild-type IL-1beta levels; however, no decrease in pro-IL-1beta synthesis or release is detected. * in culture, mutant cortical neurons exhibit inhibition of hypoxia-mediated generation of mature IL-1beta.Abnormal inflammatory response: in response to LPS-mediated acute lung injury, homozygotes exhibit a prolonged neutrophilic inflammatory response and evidence of caspase-1-independent IL-1beta production in the lung.Decreased susceptibility to endotoxin shock: * strikingly, homozygotes are significantly resistant to the lethal effects of endotoxic shock after a high dose of LPS. * whereas all LPS-treated wild-type mice die within 30 hours after injection, all homozygotes survive for >45 hours, with only 30% of mutants dying during the next 5 days.Reproductive system phenotype: * homozygotes are fertile and produce a normal litter size relative to wild-type. * in addition, post-lactation involution of mammary glands remains grossly normal in mutant post-partum females.Decreased susceptibility to ischemic brain injury: * following right carotid artery ligation, newborn homozygotes (P9-P10) are resistant to moderate, but not to severe cerebral hypoxic-ischemic insults relative to wild-type mice. * under mild lesioning conditions (right carotid ligation plus 40 min 10% O2), newborn homozygotes show attenuated hypoxia-ischemia induced CCL2 (chemokine (C-C motif) ligand 2; also, MCP-1) expression at 8 h post-hypoxia relative to wild-type; no genotype differences in CCL2 production are observed in animals undergoing longer periods of hypoxia-ischemia (severe insult)>Decreased neuron apoptosis: * cultured cerebrocortical neurons from homozygotes are highly resistant to oxygen/glucose deprivation (OGD)-induced neuronal cell death, showing only 50% of lactate dehydrogenase release relative to wild-type neurons. * also, mutant neurons are highly resistant to Ripk2-mediated cell death; transfecting caspase-1 into mutant neurons restores sensitivity to Ripk2-induced apoptosis. * notably, cultured neurons show inhibition of OGD-mediated processing of various members of the caspase pathway, cleavage of Bid, and hypoxia-associated loss of mitochondrial transmembrane potential; in vivo, these findings are confirmed in a cerebral ischemia model.","Decreased interleukin-1 beta secretion: * heterozygotes are slightly impaired in their capacity to produce mature IL-1beta: ex vivo, heterozygous peritoneal macrophages stimulated with LPS and ATP release 50% of wild-type IL-1beta levels * no decrease in pro-IL-1beta synthesis or release is detected","C57BL/6 x 129S2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12","Cryopreserved sperm",9,0,"ANU",null,"false",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[5559,"Nos2 KO","B6;129S7-Nos2<tm1Mrl>/AnuApb",null,"Recessive","nitric oxide synthase 2, inducible","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2a","MGI:97361","nitric oxide synthase 2, inducible; targeted mutation 1, John S Mudgett","Nos2<tm1Mrl>","MGI:2158791","11",{"$nulls":28},"Abnormal osteoclast morphology.Decreased osteoclast cell number: decreased by 25%Abnormal osteoclast differentiation: in vitro differentiation is markedly attenuated.Abnormal osteoclast physiology: resorption activity is considerably decreased.Increased bone mineral density: bone mineral density of the femur is elevated at both 4 and 9 weeks of age.Increased bone volume: total bone volume is increased.Increased compact bone mass: * increased cortical bone mass * trabecular bone thickness and connectivity unchanged from controls.Abnormal tooth hard tissue morphology: distance between cementoenamel junction and alveolar bone crest is greater than for controls from 6 weeks on (without any bacterial challenge).Abnormal response to infection: * do not respond to oral infection with Porphyromas gingivalis by bone loss * serum levels of specific IgG are comparable to controlsAbnormal involution of the mammary gland: * mammary gland regression after removal of pups is delayed * degree of regression at 72 hours is similar to controls * mammary gland development is normal at 10 days into lactation.Abnormal mammary gland physiology: increase in apoptosis levels of involuting mammary glands is delayed.Abnormal lactation: * elevated milk production * pups nourished by mutant mothers weigh more than pups nourished by control mothers.Increased circulating prolactin level: slightly elevated relative to controls.Abnormal cardiovascular system morphology.Abnormal uterine artery morphology: the large arteries of the uterus during pregnancy have thickened arterial walls and smaller lumina.Atherosclerotic lesions: found in about 35% of homozygotes.Abnormal heart ventricle morphology: total ventricle weights are greater than controls for males only.Abnormal cardiovascular system physiology.Abnormal blood circulation: islet blood flow under basal conditions is increased.Increased systemic arterial blood pressure.Increased mean systemic arterial blood pressure: * relative to controls * streptozotocin induced diabetes for 8 days results in a more modest increase in blood pressure than in similar controls.Increased systemic arterial systolic blood pressure: slightly increased at 3 months of age but not later.Increased infarction size: * area of infarction is greater than for controls in non-diabetic mice after ischemia-reperfusion * reperfusion injury is less in diabetic mice than in diabetic controls.Homeostasis/metabolism phenotype: * normal serum insulin. * obese mice on a high fat diet have normal insulin levels.Abnormal blood homeostasis.Increased circulating creatinine level: slightly elevated levels.Abnormal circulating estradiol level: the cyclic changes in estradiol level are abnormal in homozygous mutant females with the peak in estradiol concentration coming later than in 129/SvEv wild-type females.Increased circulating cholesterol level: levels 1.7 times normal at 9 months of age.Increased circulating triglyceride level: elevated plasma triglycerides.Abnormal circulating serum albumin level: slightly reduced at 3 months and tending to decline with age.Abnormal glucose homeostasis.Abnormal circulating glucose level: resistant to hyperglycemia induced by multiple low doses of streptozotocin.Improved glucose tolerance: * hyperglycemic in the first 30 minutes of a glucose tolerance test. * return to fasting glucose levels by 90 minutes when controls are still hyperglycemic.Increased insulin sensitivity.Abnormal hormone level.Decreased adiponectin level.Abnormal adrenocorticotropin level: plasma ACTH levels increase much more modestly after LPS treatment than for controls.Increased renin activity: plasma renin activity is increased.Decreased cerebral infarction size: * volume of infarction 96 hours after middle cerebral artery occlusion is 28% smaller than controls. * volume of infarction is similar to controls 24 hours after cerebral artery occlusion.Decreased susceptibility to kidney reperfusion injury: * protected from renal ischemia-reperfusion injury as indicated by lower serum creatine levels compared to controls * less tubular necrosis, tubular structure is almost normal * better survival rate at 24 hours after surgeriesAbnormal uterus morphology: the lining of the uterus during pregnancy shows a distinct lack of cellularity in homozygous female mutants compared to wild-type females.Abnormal uterine artery morphology: the large arteries of the uterus during pregnancy have thickened arterial walls and smaller lumina.Prolonged diestrus: diestrus length is increased in homozygous mutant females compared to 129/SvEv wild-type mice without an increase in total oestrus cycle length.Decreased litter size: by mid-gestation homozygous female mutants have significantly fewer viable embryos compared to wild-type females.Nervous system phenotype: chronic nerve constriction does not lead to breakdown of small myelinated fibers.Decreased cerebral infarction size: * volume of infarction 96 hours after middle cerebral artery occlusion is 28% smaller than controls * volume of infarction is similar to controls 24 hours after cerebral artery occlusion.Neuron degeneration: * moderate breakdown of larger caliber myelinated fibers 5 days after chronic nerve constriction at a time when controls have far fewer surviving fibers * fiber numbers are declining at 14 days but at a slower rate than for controls * degenerating myelinated fibers persist longer after nerve crush injuryAbnormal peripheral nervous system regeneration: * no regenerative myelinated sprouts at 21 days when they have begun to appear in controls * regenerating fibers are smaller in caliber after nerve crush injury * similar to controls by 6 weeks after nerve crush injury * nerve fiber regeneration is delayed and new fibers are smaller in diameter after nerve transection.Increased eating behavior: consume 1.6 times as much food as controls on a high fat diet.Abnormal motor capabilities/coordination/movement: motor deficiencies improve between 24 and 96 hours after cerebral artery occlusion unlike controls.Abnormal sensory capabilities/reflexes/nociception.Allodynia: tactile allodynia observed at 3 weeks when neuropathic pain is diminishing in controls.Abnormal response to tactile stimuli: tactile hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls.Abnormal thermal nociception: * thermal hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls * delayed thermal hypersensitivity observed at 3 weeks when neuropathic pain is diminishing in controls.Pancreas inflammation: * low level of islet inflammation as compared to controls when treated with streptozotocin. * islet size is normal.Increased length of allograft survival: * lower rejection rate of CBA/CaJ cardiac grafts * lower levels of apoptosis by all measures usedDecreased susceptibility to kidney reperfusion injury: * protected from renal ischemia-reperfusion injury as indicated by lower serum creatine levels compared to controls * less tubular necrosis, tubular structure is almost normal * better survival rate at 24 hours after surgeries.Increased body weight:body weight is greater than controls for males only.Increased growth rate: experience greater weight gain on a high fat diet.Abnormal digestion: do not respond to gastric luminal acid with as great an increase in gastric blood flow as do controlsvascular resistance is not diminished.Decreased digestive mucosecretion: * mucus accumulation rate about 25% of controls * firmly adherent layer of mucus is thinner than in controlsLiver fibrosis: * fibrotic changes in the livers of mice on a high fat diet particularly around degenerating hepatocytes and the central vein area * collagen fraction is higher than in controls when on a high fat diet.Allodynia: tactile allodynia observed at 3 weeks when neuropathic pain is diminishing in controls.Abnormal response to tactile stimuli: tactile hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls.Abnormal thermal nociception: * thermal hypersensitivity disappears between 5 and 14 days after the start of chronic nerve constriction while it persists through day 14 in controls * delayed thermal hypersensitivity observed at 3 weeks when neuropathic pain is diminishing in controls.",null,"C57BL/6 x 129S7","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12","Cryopreserved sperm",40,0,"ANU",null,"false",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[5624,"B6.126Erbb4Tm2Fej/mmcd FloxedErbB4",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5244,"ENU18NIH 17a; ENU18NIH:017a","C57BL/6JAnu-Tnfsf13b<m1Anu>/AnuApb","C57BL/6JAnu-Tnfsf13b<m1Anu>/AnuApb","Recessive","tumor necrosis factor (ligand) superfamily, member 13b","Tnfsf13b","Unknown","BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4","MGI:1344376","tumor necrosis factor (ligand) superfamily, member 13b; mutation 1, Australian National University","Tnfsf13b<m1Anu>","MGI:5009047","8","ENSMUSG00000031497","ENSMUST00000033892","Tnfsf13b-201","81","81","T to A","ENSMUSE00000638270","1","27","Tyrosine to STOP",{"$nulls":4},"GAGAAAGGAGAAGATATGAAAGTGGGATATGATCCCATCACTCCGCAGAAGGAGGAGGGTG","Yes",{"$nulls":12},"T1 to T2 block in B cell development in spleen and increased % of immature B cells and decreased % of mature B cells in peripheral blood.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"1","Currently breeding at G4. Affected x affected, affected x unaffected, affected x B6","No","2010-10-15","Cryopreserved sperm",45,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","Anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,null,"MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 2, Matthias Ernst","Gpa33<tm1(Ctnnb1*)Ern>",null,"1",{"$nulls":28},"Unknown","Unknown","Mixed","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-01-24","Cryopreserved sperm",40,0,"Ludwig","ME-196 ","false",null,"Matthias","Ernst","Ludwig Institute for Cancer Research, Melbourne","matthias.ernst@ludwig.edu.au",{"$nulls":6},"029/10","040/2001 & 304","No"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","catenin (cadherin associated protein), beta 1","Ctnnb1",null,"beta catenin, beta-catenin, Bfc, Catnb","MGI:88276","catenin (cadherin associated protein), beta 1; targeted mutation 4, Walter Birchmeier","Ctnnb1<tm4Wbm>","MGI:2148594","9",{"$nulls":15},"No",{"$nulls":45},"029/10","040/2001 & 304"]
[5394,"A33/B-cat del/580's","Stock Gpa33<tm2(Ctnnb1*)Ern> Ctnnb1<tm4Wbm>  Apc<tm1Tno>/LudApb",null,"Dominant","adenomatosis polyposis coli","Apc","Reduced","CC1, Min","MGI:88039","adenomatosis polyposis coli; targeted mutation 1, Tetsuo Noda","Apc<tm1Tno>","MGI:1857966","18",{"$nulls":15},"Yes",{"$nulls":45},"029/10","040/2001 & 304"]
[5109,"APN36","B6;129-Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>/Marp",null,"Recessive","Cysteine-rich secretory protien 1 C","Crisp1",null,"Aeg1, CRISP-1","MGI:102553","cysteine-rich secretory protein 1; gene trap CMHD-GT_255A4-3, Centre for Modeling Human Disease","Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>","MGI:3879688","17",{"$nulls":15},"Yes",{"$nulls":12},"N/A: Only bred to heterozygosity","Normal","C57BL/6J","No","Unknown","Yes","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-05-05","Cryopreserved sperm",50,0,"Monash",null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu","Monash University, School of Biomedical Sciences, Level 3, Building 77, Room 306","Melbourne","VIC","Sue","Chapman","sue.chapman@monash.edu","MMCA SOP 2007/02","PC1-N09/07","No"]
[2362,null,"B6.AK-H2<k>/AnuApb","B6.AK-H2<k>/Apb","Dominant","histocompatibility-2, MHC","H2","Unknown","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17",{"$nulls":15},"Yes",{"$nulls":12},"The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Fas<lpr>/J",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-13","Cryopreserved sperm",120,0,"ANU","024","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4849,"ENU6AT:HELxTCR:line014:Infertility:G4","ENU6AT:14:infertility",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Male infertility","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",5,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[4733,null,"B6;B10Br;129-Cblb<tm1Pngr> Tg(MLsHEL)Ccg ",null,"Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","Cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","soluble Hen Egg Lysozyme (HEL)","H-2K<b>","high",{"$nulls":9},"Defect in T cell signalling",null,"C57BL/6 x C57BL/10.Br x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","1","2",null,"No","2009-04-19","Cryopreserved sperm",30,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[4975,"Booreana ; Ped11.28 ; ENU11B6:028","B10;B6-Myb<boo>/AnuApb","B10;B6-Myb<boo>/AnuApb","Recessive","myeloblastosis oncogene","Myb","Unknown","c-myb","MGI:97249","myeloblastosis oncogene; booreana","Myb<boo>","MGI:4867909","10","ENSMUSG00000019982","ENSMUST00000020156","Myb-201","923","1189","A to G","ENSMUSE00000644654","8","308","Glutamic acid to Glycine",{"$nulls":4},"GGAGTTGCTCCTGATGTCAACAGAGAACGAGCTGAAGGGACAGCAGGCATTACCAACACAG","Yes",{"$nulls":12},"E14.5 embryo:15x increase in platelet numbers2x increase in stem cells in foetal liver.Increase in primitive RBCDecrease in definitive RBCIncrease in haemopoietic  progenitor cellsPups are born and survive to adulthood. Adults display a 5x increase in platelet numbers","Normal","C57BL/6 x C57BL/10","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm",30,0,"ANU",null,"false",null,"Andrew","Perkins","The University of Queensland","a.perkins@imb.uq.edu.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","J.APF.13.08","N/A","No"]
[4734,"Cbl-b KO:Hamlet:Charles","B6.129-Cblb<tm1Pngr> Tg(IghelMD4)4Ccg Tg(MLsHEL)Ccg/AnuApb",null,"Semi-dominant","Casitas B-lineage lymphoma b","Cblb","Nil","cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":11},"Defect in T cell signalling",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"10",null,"No","2009-04-19","Cryopreserved sperm",45,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"immunoglobulin kappa chain complex, immunoglobulin heavy chain complex. (IgM and IgD). Genomic clones of H+L genes with normal control elements. soluble HEL (hen egg lysozyme)","H-2K<b>"]
[7268,null,"SJL/J-Ank1<MRI95845>/MriApb","SJL/J-Ank1<MRI95845>","Dominant","ankyrin 1, erythroid","Ank1","Unknown","Ank-1, pale","MGI:88024","ankyrin 1, erythroid; MRI98545","Ank1<MRI98545>",null,"8","ENSMUSG00000031543","ENSMUST00000121802","Ank1-004","445","699","T to A","ENSMUSE00000995112","5","149","Tyrosine to Asparagine",{"$nulls":4},"CCCAGTCTCAGAAAGGCTTTACTCCCCTGTACATGGCTGCTCAGGAGAACCACTTGGAAGT",{"$nulls":13},"Pre and Perinatal mortality with Jaundice, enlarge spleen and fragmented red blood cells","Heterozygous mice display a microcytic anaemia with increase osmotic fragility, splenomegaly and survival advantage to Plasmodium chabaudi ","SJL/J","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-02-05","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7627,"ENU28:G3","ANU:ENU28:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2014-03-31","Cryopreserved sperm",44,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[3488,"Il-1R KO","C57BL/6-Il1r1<tm1>",null,"Recessive","interleukin 1 receptor, type I","Il1r1","Nil","CD121a, IL-1 receptor alpha chain, Il1r-1","MGI:96545",{"$nulls":3},"1",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mice are grossly normal but fail to respond to IL-1. Mildly immunocompromised",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,null,"WEHI #749","true",null,"Ian","Wicks","Walter and Eliza Hall Institute of Medical Research","wicks@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5369,"NODSocs1/Lck","NOD/Lt-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Lck-cre)157Jxm",null,"Recessive","suppressor of cytokine signaling 1","socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research",null,"MGI:2656917","16",{"$nulls":15},"Yes","transgene insertion I57, Jamey Marth","lymphocyte protein tyrosine kinase (Lck)",{"$nulls":10},"Decreased B cell number: large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes.Abnormal T cell subpopulation ratio: * increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1. * increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged.Abnormal T cell differentiation: enhanced differentiation of thymocytes toward CD8+ T cells.Abnormal T cell activation: almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype.Abnormal CD4-positive T cell morphology: mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size.Increased CD4-positive T cell number: increase in CD4+ T cells in the blood.Abnormal CD8-positive T cell morphology: mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size.Increased CD8-positive T cell number:  * large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age. * increase in CD8+ T cells in the bloodAbnormal thymus medulla morphology: enlarged thymic medulla.Thymus hyperplasia: increase in thymus cellularity predominately due to an increase in CD8+ T cell population.Enlarged lymph nodes.Lymph node hyperplasia: lymph nodes contain 2-fold the number of cells in controls.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #67","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5369,"NODSocs1/Lck","NOD/Lt-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Lck-cre)157Jxm",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","suppressor of cytokine signaling 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs1<tm1Wehi>","MGI:1934607","16",{"$nulls":15},"No",{"$nulls":45},"N/A","N/A"]
[3594,null,"C57BL/6-Tlr4 mutant",null,"Recessive","toll-like receptor 4","Tlr4","Unknown","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824",{"$nulls":3},"4",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06",null,0,0,null,"WEHI #1935","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":3},"Ken ","Shortman","shortman@wehi.edu.au","N/A","N/A","No"]
[6242,"Bmf/473","B6.129-Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 2.1, Philippe Bouillet","Bcl2l11<tm2.1Boui>","MGI:4366751","2",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2515","true",null,"Philippe","Bouillet","Walter and Eliza Hall Institute of Medical Research","bouillet@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6242,"Bmf/473","B6.129-Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":61},"N/A","N/A"]
[5446,"ENU12NIH:071b N2","C57BL/6JAnu-Hmbs<m1Anu>/AnuApb","C57BL/6JAnu-Hmbs<m1Anu>/AnuApb","Dominant","hydroxymethylbilane synthase","Hmbs",null,"PBGD, porphobilinogen deaminase, Ups, Uros1","MGI:96112","hydroxymethylbilane synthase; mutation 1, The Australian National University","Hmbs<m1Anu>","MGI:5563463","9","ENSMUSG00000032126","ENSMUST00000077353","Hmbs-201","719","905","A to G","ENSMUSE00000216802","11","240","Aspartic acid to Glycine",{"$nulls":4},"TATCTTGGACCTAGTGAGTGTGTTGCACGATCCTGAAACTCTGCTTCGCTGCATTGCTGAA","Unknown",{"$nulls":12},"Autoflourescence during FACs runs","Autoflourescence during FACs runs","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","1","5","Affected x B6","No","2011-02-28","Cryopreserved sperm",46,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","Anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[6245,"506","C57BL/6-Bcl2l11<tm3.1Boui>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 3.1, Philippe Bouillet","Bcl2l11<tm3.1Boui>","MGI:4366756","2",{"$nulls":28},"Increased leukocyte cell number:*Smaller increase in white blood cells numbers (<1.5 fold).Increased spleen weight:*Smaller increase in spleen weight.Immune system phenotype:*Normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1718","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7482,"Cxcr KO","C57BL/6-Cxcr3<tm1Wwh>/MarpAnuApb",null,"Recessive","chemokine (C-X-C motif) receptor 3","Cxcr3",null,"Cd183, Cmkar3, Cxcr3","MGI:1277207","chemokine (C-X-C motif) receptor 3; targeted mutation 1, Wayne W Hancock","Cxcr3<tm1Wwh>","MGI:2180682","X",{"$nulls":28},"Females:Decreased susceptibility to viral infection induced morbidity/mortality:\t• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive.Impaired macrophage chemotaxis:• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle.Abnormal cellular extravasation:\t• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis.• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells.• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia.Abnormal interferon level:• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days.Lung inflammation:\t• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury.• reduced numbers of CD8+ T cells after bleomycin injury.• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice.Decreased susceptibility to viral infection:• lack symptoms of infection at 7 days after infection with lymphocytic choriomeningitis virus.• less susceptibility to lymphocytic choriomeningitis virus.Increased length of allograft survival:• increased cardiac allograft survival.• grafts with fewer Cd4+ and Cd8+ T cells.Abnormal physiological neovascularization:\t• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls.• poor recovery of blood flow after schema.Abnormal interferon level:\t• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-14","Cryopreserved sperm",11,0,"ANU","522","false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":6},"2013/12","13.08","No"]
[4745,"Lyn:Hamlet","B6.129-Lyn<tm1Ard> Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Unknown","Hck-2","MGI:96892","targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"15",null,"No","2009-04-27","Cryopreserved sperm",150,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@gmail.com","N/A","N/A","No"]
[5626,"B6.129 S2.Oprm1 tm1KGf/J (mu-opoid)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6621,"ENU19WT 029a:G2","ANU:ENU19WT:029:a:G2",null,"Semi-dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-14","Cryopreserved sperm",10,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","A2011/41","N/A","No"]
[7058,"Crisp1 KO","B6;129-Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>/Marp",null,"Recessive","Cysteine-rich secretory protien 1 C","Crisp1",null,"Aeg1, CRISP-1","MGI:102553","cysteine-rich secretory protein 1; gene trap CMHD-GT_255A4-3, Centre for Modeling Human Disease","Crisp1<Gt(CMHD-GT_255A4-3)Cmhd>","MGI:3879688","17",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6J","No","Unknown","Yes","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-08-22","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Duangporn","Jamsai","Monash University","duangporn.jamsai@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[5641,"Box 1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5561,"WT control","B6;129/Sv",null,"Dominant",{"$nulls":37},"WT control for researchers experiments",null,"C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-12",null,0,0,null,null,"true",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[5370,"377SCID","NOD/Lt.Cg-Tg(Ins2-Cd80)377-6Wehi Prkdc<scid>",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes","CD80 antigen","rat insulin promoter","islet cells",{"$nulls":9},"Introduction of the CD80 transgene into the nonobese diabetic (NOD) genetic background resulted in early spontaneous autoimmunity, but splenocytes from the diabetic animals could only transfer diabetes to NOD<scid> recipients that expressed CD80 on their β cells. Islet destruction required continuousCD80 expression by target β cells.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #75","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5371,"B6IL-1R","B6.Cg-Il1r1<tm1Rom>/JWehi",null,"Recessive","interleukin 1 receptor, type I","Il1r1","Nil","CD121a, IL-1 receptor alpha chain, IL-iR, Il1r-1","MGI:96545","interleukin 1 receptor, type I; targeted mutation 1, Mark A Labow","Il1r1<tm1Roml>","MGI:1857441","1",{"$nulls":15},"No",{"$nulls":15},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #76","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7066,"Momme D30","FVB/NJ-MommeD30 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D30","MommeD30",{"$nulls":6},"17",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD30<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm",40,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[5555,"IL-1RA KO","B6;129S-Il1rn<tm1Dih>/Anu",null,"Recessive","interleukin 1 receptor antagonist","Il1rn","Nil","IL-1ra","MGI:96547","interleukin 1 receptor antagonist; targeted mutation 1, David Hirsh","Il1rn<tm1Dih>","MGI:2157398","2",{"$nulls":28},"Decreased body weight: lower body weight apparent by 6 weeks of age.Decreased circulating interleukin-1 level: decreased serum levels of IL1 after endotoxin exposure.Increased circulating interleukin-6 level: increased basal serum IL6 levels.Abnormal circulating serum amyloid protein level: increased basal serum amyloid P levels.Increased acute inflammation: increased hepatic acute phase protein response to subcutaneous turpentine administration, increased mortality to turpentine abscess induction: 50% of mice died by day 5.Increased susceptibility to endotoxin shock: more susceptible to lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to bacterial infection: less susceptible to experimental Listeria monocytogenes infection.Reduced fertility: decreased number of offspring.Decreased circulating cholesterol level: 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks.","Increased susceptibility to endotoxin shock: more susceptible to lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to bacterial infection: less susceptible to experimental Listeria monocytogenes infection, heterozygotes display an intermediate phenotype.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival to ANU",null,"No","2011-08-12",null,0,0,null,null,"true",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[6623,"TG2.129T2","129-Tgm2<tm1.1Rmgr>/Apb",null,"Recessive","transglutaminase 2, C polypeptide","Tgm2","Nil","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 1.1, Robert M Graham","Tgm2<tm1.1Rmgr>","MGI:3527996","2",{"$nulls":15},"No",{"$nulls":12},"Abnormal cell adhesion: fewer homozygous fibroblasts (20% versus 79% of wild-type) adhered to poly-L-coated or fibronectin coated slidesAbnormal T cell physiology: 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired.",null,"129T2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-18","Cryopreserved sperm",50,0,"Victor Chang",null,"false",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[823,"ACTFLPtg","B6.Cg-Tg(ACTFLPe)9205Dym/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 9205, Susan Dymecki","ACTB, actin, beta, human","The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively",{"$nulls":9},"The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively. ","Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,"Moss Vale","495","true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[119,"c-cbl KO","B6.129S1-Cbl<tm1Ddlb>/WlanAnuApb","B6.129S1-Cbl<tm1Ddlb>/WlanAnuApb","Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","11",null,null,"No","2006-02-06","Cryopreserved sperm",145,0,"ANU",null,"false",null,"Wally","Langdon","The University of Western Australia","wlangdon@cyllene.uwa.edu.au",{"$nulls":3},"Wally","Langdon","wlangdon@cyllene.uwa.edu.au","AEC","N/A","No"]
[3530,null,"Balb/c-Rag1",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848",{"$nulls":3},"1",{"$nulls":15},"Yes",{"$nulls":12},"Immuncompromised",null,"Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29",null,0,0,null,"WEHI #960","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[2039,"STAT1 KO","B6;129-Stat1<tm1Rds>/Apb","B6;129-Stat1<tm1Rds>/Apb","Recessive","signal transducer and activator of transcription 1","Stat1","Nil",null,"MGI:103063","targeted mutation 1, Robert D Schreiber","Stat1<tm1Rds>","MGI:1861949","1",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Increased sensitivity to microbial pathogens and viruses due to impaired responsiveness to interferons.Increased Bone mass.Increased osteoclast cell number.","No phenotype reported.","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"homozygous x homozygous","Yes","2007-09-21","Cryopreserved sperm",115,0,"Monash",null,"false",null,"Brendan","Jenkins","Monash University","brendan.jenkins@med.monash.edu.au",{"$nulls":3},"Brendan","Jenkins","brendan.jenkins@med.monash.edu.au","N/A","N/A","No"]
[1861,"Sox2-Cre","CD1-Tg(Sox2-cre)1Amc",null,"Recessive",{"$nulls":25},"transgene insertion 1, Andrew P McMahon","SRY-box containing gene 2 (Sox2)",{"$nulls":10},"Cre expression in epiblast.",null,"CD1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1052","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6876,"BRINP3 Targeted","C57BL/6-Fam5c<tm1>/Marp",null,"Recessive","family with sequence similarity 5, member C","Fam5c",null,"DBC3, B830045N13Rik","MGI:2443035",{"$nulls":3},"1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-23","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Phil","Bird","Monash University","phil.bird@monash.edu",{"$nulls":3},"Susie","Berkowicz","Susie.berkowicz@monash.edu","SOBS/B/2008/30BC","NLRD-3430","No"]
[7062,"Momme D11","FVB/NJ-MommeD11 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D11","MommeD11","Unknown",{"$nulls":5},"8",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~E14.5 dpc)","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD11<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm",20,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[5628,"B6.129P2-Lgr5",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5948,"NOD.CD45.2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[840,"CD40 KO","B6.129P2-Cd40<tm1kik>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.Immune system phenotype: normal numbers and ratios of T and B cells.Decreased neutrophil cell number:* in non-SPF facilities compared to wild-type controlsAbsent spleen germinal center: failed to form.Abnormal humoral immune response.Decreased immunoglobulin level:* reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin.* response to thymus-independent (TI) antigens was in tact.Decreased susceptibility to type II hypersensitivity reaction:*in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis* deposition of IgG and complement in glomeruli not observed* glomeruli almost normal* fibrin deposition in glomeruli not observed* failure to induce proteinuria",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2007-05-23",null,0,0,"Moss Vale",null,"true",null,"Rob","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Rob","Brink","r.brink@garvan.org.au","N/A","N/A","No"]
[5161,"ENU14 NIH 17b","ENU14NIH:017b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Shaky gait, and uncoordinated","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Unknown","Yes","Yes","Poor",null,"1",null,"No","2010-06-28","Cryopreserved sperm",20,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au","117 Garran Rd, ANU","Canberra","ACT","Alanna","Craven","Alanna.Craven@anu.edu.au","J.APF.13.08","N/A","No"]
[7064,"Momme D21","FVB/NJ-MommeD21 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D21","MommeD21",{"$nulls":6},"16",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD21<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[5474,"Rosa 26; MF-05","C57BL/6-Gt(ROSA)26Sor<tm1Sor>/Apb",null,"Recessive",{"$nulls":25},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-04-06","Cryopreserved sperm",50,0,"Ludwig","MF-05","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"018/09","040/2001 &304","No"]
[3405,"C57BL/6. ACT-mOVA - H2b","C57bL/6-H2-K<bm1> Tg(CAG-OVA)916Jen/Wehi",null,"Dominant",null,null,"Normal",null,null,"histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17",{"$nulls":15},"Yes","transgene insertion 916, Marc K Jenkins","chicken β-actin",{"$nulls":10},"Ubiquitously express membrane bound chicken ovalbumin under the control of chicken β-actin promoter. Breed less well than hets",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13",null,0,0,null,"WEHI #100","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5630,"B6.129S6-Erap1tm1Luc/J (ERAP) ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5629,"B6.129S2.Oprm1tm1Kff/J ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3539,null,"C57BL/6-Mixl1-lacZ KO",null,"Recessive","Mix1 homeobox-like 1 (Xenopus laevis)","Mixl1","Normal","Mm1, Mml","MGI:1351322","Mix1 homeobox-like 1 (Xenopus laevis); targeted mutation 1, Lorraine Robb ","Mixl1<tm1Robb>","MGI:2387828","1",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal- embryonic lethality during organogenesis - homozygous embryos are present in normal numbers at E7.5, but are absent after E10.5. Embryos with severely disorganized head folds are only rarely recovered at E9-9.5; such embryos have failed to turn or form a heart tube. At E9.5, axial tissue mass present at E8.5 has grown and developed into huge mass of tail bud-like tissue protruding dorsally from caudal region of embryo, giving impression that axis is bifurcated.  Abnormal embryogenesis/ development - at E8.5, embryos adopt a flattened disc morphology instead of a lordotic shape. Abnormal primitive streak morphology - by E7, mutants display a thickened primitive streakan excess of mesoderm-like cells accumulates in anterior streak and in region lateral to streak at E7. Abnormal Henson's node morphology - homozygotes lack a recognizable node at E7Abnormal rostral-caudal axis patterning - at E8.5, AP axis is markedly shortenedAbnormal axial mesoderm.  Abnormal embryonic tissue morphology - definitive endoderm is specified, but gut morphogenesis is defective in mutants. Abnormal notochord morphology - notochord is replaced by a thick axial mass of flattened neuroectoderm overlying a condensed core of mesodermal tissues. At E9.5, mutants have a poorly organized structure resembling the notochordal plate and a notochord-like structure that ends caudally either in an ectopic protrusion or in a bulbous mass. Abnormal somite development - from two to five somite pairs form in the paraxial mesoderm flanking a thick axial mass of flattened neuroectoderm overlying a condensed core of mesodermal tissues. Enlarged allantois - compared to wild type, allantois is disproportionately large.Abnormal neural fold formation (J:77443)at E8.5, neural folds are small and disorganized with little head mesenchyme found beneath the head folds. Abnormal neural fold elevation formation - in early-neural plate stage (E7.75), elevation of neural folds is retarded and a shallow anterior intestinal portal developscardiovascular system.  Abnormal heart tube morphology - heart tube is absent at E8.25. Abnormal foregut morphology - foregut invagination is rudimentary and no hindgut portal is formed by E8.25.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-29",null,0,0,null,"WEHI #1074","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[4996,"4AT22","ENU4AT:22",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Anti-nuclear antibodies, high.Both young and older mice.","Normal","C57BL/6 x B10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",40,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Gerard","Hoyne","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[4995,"4AT36 ; jellybean","ENU4AT:036",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background.Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",30,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Gerard","Hoyne","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[4898,"129/Sv","129/Sv Wildtype",null,"Dominant",{"$nulls":37},"Normal.",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-10-09","Cryopreserved sperm",60,0,null,null,"false",null,"Alexander","Larcombe","Telethon Institute for Child Health Research","alexanderl@ichr.uwa.edu.au",{"$nulls":3},"Alexander","Larcombe","alexanderl@ichr.uwa.edu.au","TICHR AEEC 160","Exempt R9","No"]
[6887,"APN178","C57Bl/6N-Gpx3<tm1a(KOMP)Wtsi>/MarpApb",null,"Recessive","glutathione peroxidase 3","Gpx3 ","Unknown","EGPx, extracellular GPx, GPx, plasma GPx ","MGI:105102","glutathione peroxidase 3; targeted mutation 1a, Wellcome Trust Sanger Institute ","Gpx3<tm1a(KOMP)Wtsi> ","MGI:4841147","11",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-03","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS 2010/08","PC1 N09/07","No"]
[170,"RetTGM","C57BL/6-Ret<tm1Jmi>",null,"Recessive","ret proto-oncogene","Ret","Nil","RET51, RET9","MGI:97902","targeted mutation 1, Jeffrey Milbrandt","Ret<tm1Jmi>","MGI:2449909","6",{"$nulls":15},"Yes",{"$nulls":12},"All cells expressing Ret express GFP in both the nucleus and cytoplasm. Homozygous null mice die at birth, probably from gut motility defects.","None reported","C57BL/6","No","No","No","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[6924,"ENU20:B6:28:b","ANU:ENU20:028:b",null,"Recessive","Unknown","unknown",{"$nulls":6},"Unknown",{"$nulls":29},"We are currently looking for a prostate phenotype.","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-06-28","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[5159,"NODEYFP","NOD.129-Gt(ROSA)26Sor<tm1(EYFP)Cos>/MarpApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":28},"Normal NOD mouse: reporter mouse for cre expression","Normal NOD mouse: reporter mouse for cre expression","NOD","No","Unknown","Yes","No","Unknown","Yes","No","Unknown","10+",null,null,"No","2010-06-28","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Robyn","Slattery","Monash University","robyn.slattery@monash.edu","Dept Immunology, 2nd floor Monash bldg, Alfred Hospital, Commercial Rd,","Prahran","Victoria","Robyn","Slattery","Robyn.Slattery@monash.edu","E/0905/2009/M","PC1-N42/07","No"]
[6615,"PIPP Floxed","C57BL/6J-Inpp5j<tm1>/Marp",null,"Dominant","inositol polyphosphate 5-phosphatase J","Inpp5j","Unknown","Pib5pa, Pipp","MGI:2158663",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-12","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Christina","Mitchell","Monash University","christina.mitchell@monash.edu",{"$nulls":3},"Lisa","Ooms","lisa.ooms@monash.edu","SOBS/B/2006/57","PC1 N51/07","No"]
[6626,"MH2","FVB-Tg(TetO-Myh6*R403Q)1Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion 1, Robert Graham","tetO-CMV",{"$nulls":10},"Normal",null,"FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[7271,"APN182","C57BL/6N<Atm1Brd> Tnfsf13<tm1(KOMP)Wtsi>/Marp",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 13","Tnfsf13 ","Unknown","2310026N09Rik, APRIL, TALL2, TRDL1","MGI:1916833","tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Wellcome Trust Sanger Institute/Monash Animal Research Platform","Tnfsf13<tm1(KOMP)Wtsi>/Marp ","MGI:4419527","11",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-02-06","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[5652,"C57BL/6J hPG",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7299,"RBC16","C;B6-Cpox<Rbc16>/MarpApb",null,"Dominant","coproporphyrinogen oxidase","Cpox","Unknown","Cpo","MGI:104841",{"$nulls":3},"16",{"$nulls":28},"Embryonic lethal at E10.5","Low mean cell volume and mean cell hemoglobin and anemia","BALB/C","No","No","Yes","No","No","Yes","No","Good",null,null,"Heterozygous intercrosses","No","2013-03-26","Cryopreserved sperm",59,0,"Monash",null,"true",null,"Fiona","Brown","Monash University","fiona.brown2@monash.edu",{"$nulls":6},"E/1134/2011/M","PC2-N17-11 ","No"]
[5376,"HinsA Triple 427","C57BL/6-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427 Tg(Ins2-INS1)/Apb",null,"Dominant",{"$nulls":39},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-22","Cryopreserved sperm",50,0,"St V",null,"false",null,"Stuart","Mannering","St Vincent's Institute","smannering@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6925,"APN151","C57BL/6N-A<tm1Brd> Ptafr<tm1a(KOMP)Wtsi>/MarpApb",null,"Recessive","platelet-activating factor receptor","Ptafr","Unknown","PAFR, PAF receptor","MGI:106066","platelet-activating factor receptor; targeted mutation 1a, Wellcome Trust Sanger Institute ","Ptafr<tm1a(KOMP)Wtsi> ","MGI:4460278","4",{"$nulls":28},"Unknown","Normal","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-06-28","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS 2010/08","PC1N09/07","No"]
[6627,"tTA","FVB.Cg-(myh6-tTA)6Smbf",null,"Dominant",{"$nulls":25},"transgene insertion 6, Section of Myocardial Biology - Fishman Lab","rat Myh6 and tetracycline transactivator sequence","cardiac tissue",{"$nulls":9},"Normal",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[7629,null,"B6/Mrit-131297","B6/Mrit-131297","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a growth delay for a week.","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[3555,null,"B6.C-Lmo4<tm1Sho>/Wehi",null,"Recessive","LIM domain only 4","Lmo4","Normal","A730077C12Rik, Crp3, Etohi4","MGI:109360","LIM domain only 4; targeted mutation 1, Stuart Orkin ","Lmo4<tm1Sho>","MGI:3035911","3",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"C57BL/6 x BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31",null,0,0,null,"WEHI #1291","true",null,"Geoff","Lindeman","Walter and Eliza Hall Institute of Medical Research","lindeman@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6628,"A1A1tg","FVB-Tg(Myh6-Adra1a)A1A1Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion A1A1, Robert M Graham"," rat alpha-myosin heavy chain promoter","heart",{"$nulls":9},"Premature death:  * 83 of 171 die at a mean age of 155 days with a cumulative mortality of 48.5%. * premature death is sudden with no signs of heart failureCardiac fibrosis: develop progressive cardiac fibrosis with age, beginning at 2 months of age.Increased cardiac muscle contractility: exhibit enhanced contractility as evidenced by a 33% increase in fractional shortening, a 72% decrease in left ventricle (LV) internal dimension at end-systole, an 8% decrease in LV internal dimension at end-diastole, an 80% increase in maximum dP/dt, a 76% increase in dP/dt max/LVPinst, and a 104% increase in dP/dt max:dP/dt min.Increased ventricle muscle contractility: * 1-month old mutants exhibit enhanced left ventricle contractility with no change or a slight decrease in LV relaxation, resulting in a marked increase in the ratio of dP/dt max to dP/dt min. * cardiac contractility declines with age and diastolic function is reduced, although older mutants still show an increase in dP/dt max compared to wild-type.Abnormal cardiac muscle relaxation: time constant of isovolumetric relaxation is prolonged by 40%, indicating impaired relaxation.Decreased left ventricle diastolic pressure: LV end-diastolic pressure is significantly lower.Increased heart rate: * heart rate is 16% higher than in controls, however no alterations in systolic or diastolic aortic pressure is seen. * baseline heart rate is increased by 17-27% at 2 months of age, however this difference is no longer seen in older mutants.Decreased QRS amplitude: death is preceded by a marked and progressive decrease in the QRS amplitude.",null,"FVB/N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[340,"TgAPP751 (Tg72-3 line)","B6.SJL-Tg(APP751)72-3Aust ",null,"Dominant",{"$nulls":25},"amyloid beta (A4) precursor protein","moPrP, hamster prion protein promotor",{"$nulls":10},"Transgene primarily expressed in brain.No overt phenotype, normal growth and breeding.","No overt phenotype, normal growth and breeding.","C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Strain is homozygous for transgene. Positive male breeds with female.","Yes","2006-09-22","Cryopreserved sperm",90,0,null,null,"true",null,"Qiao-Xin","Li","The University of Melbourne","q.li@unimelb.edu.au",{"$nulls":3},"Qiao-Xin","Li","q.li@unimelb.edu.au","N/A","N/A","No"]
[6629,"A1A2tg","FVB-Tg(Myh6-Adra1a)A1A2Rmgr",null,"Dominant",{"$nulls":25},"transgene insertion A1A2, Robert M Graham"," rat alpha-myosin heavy chain promoter","heart",{"$nulls":9},"Premature death:  * 83 of 171 die at a mean age of 155 days with a cumulative mortality of 48.5%. * premature death is sudden with no signs of heart failureCardiac fibrosis: develop progressive cardiac fibrosis with age, beginning at 2 months of age.Increased cardiac muscle contractility: exhibit enhanced contractility as evidenced by a 33% increase in fractional shortening, a 72% decrease in left ventricle (LV) internal dimension at end-systole, an 8% decrease in LV internal dimension at end-diastole, an 80% increase in maximum dP/dt, a 76% increase in dP/dt max/LVPinst, and a 104% increase in dP/dt max:dP/dt min.Increased ventricle muscle contractility: * 1-month old mutants exhibit enhanced left ventricle contractility with no change or a slight decrease in LV relaxation, resulting in a marked increase in the ratio of dP/dt max to dP/dt min. * cardiac contractility declines with age and diastolic function is reduced, although older mutants still show an increase in dP/dt max compared to wild-type.Abnormal cardiac muscle relaxation: time constant of isovolumetric relaxation is prolonged by 40%, indicating impaired relaxation.Decreased left ventricle diastolic pressure: LV end-diastolic pressure is significantly lower.Increased heart rate: * heart rate is 16% higher than in controls, however no alterations in systolic or diastolic aortic pressure is seen. * baseline heart rate is increased by 17-27% at 2 months of age, however this difference is no longer seen in older mutants.Decreased QRS amplitude: death is preceded by a marked and progressive decrease in the QRS amplitude.",null,"FVB/N","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[6921,"Recql4 fl/fl","C57BL/6-Recql4<tm2272Arte>/Apb",null,"Dominant","RecQ protein-like 4","Recql4","Nil",null,"MGI:1931028","Recql4 fl/fl",null,null,"15",{"$nulls":28},"homozygous fl/fl mice are normal, viable and fertile",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","generated on pure C57BL/6 so not backcrossed. Only maintained on C57",null,"fl/+ to fl/+","No","2012-06-27","Cryopreserved sperm",97,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":3},"Carl","Walkley","cwalkley@svi.edu.au","044/10","IBC166, GBNML 218","Yes"]
[7633,null,"SJL/ASAM<MRI92482>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[336,"Zfp145<tm1>","129-Zbtb16<tm1Ppp>",null,"Recessive","zinc finger and BTB domain containing 16","Zbtb16","Nil","Green's luxoid, PLZF, Zfp145","MGI:103222","targeted mutation 1, Pier Paolo Pandolfi","Zbtb16<tm1Ppp>","MGI:2182708","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2006-05-05",null,0,0,null,null,"true",null,"Bryan","Williams","Monash University","bryan.williams@med.monash.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6250,"UBC-GFP","C57BL/6-Tg(UBC-GFP)30Scha/J",null,"Dominant",{"$nulls":25},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1266","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5655,"C5aR KO ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7665,"Gsto KO","B6;129/Sv-Gsto1<tm1Tac>/TacAnuApb",null,"Recessive","glutathione S-transferase omega 1","Gsto1",null,"GSTX, p28","MGI:1342273",{"$nulls":3},"19",{"$nulls":28},"Unknown",null,"C57BL/6NTac","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-04-15","Cryopreserved sperm",48,0,null,null,"true",null,"Philip","Board","The Australian National University","Philip.Board@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7522,"TgC100.WT","B6.DBA-Tg(ACTB-APP)1Colm/ArcApb","B6.DBA-Tg(ACTB-APP)1Colm/Arc","Dominant",{"$nulls":25},"transgene insertion 1, Colin L Masters","human beta actin","High",{"$nulls":9},"Abnormal emotion/affect behaviour:• old mice exhibit decreased immobility during a forced swim test compared with wild-type mice.Behavioral despair:• young mice exhibit increased immobility during a forced swim test compared with wild-type mice.Decreased startle reflex:• in young mice but not old miceHyperactivity:• in young, but not old, mice exhibit increased activity in an open field test and entries in a Y-maze compared with wild-type mice• at 9 and 22 months, mice exhibit slight hyperactivity compared with wild-type mice",null,"C57BL/6 x DBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"26","sib x sib","No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Colin","Masters","The University of Melbourne","c.masters@unimelb.edu.au",{"$nulls":3},"Qiao-Xin","Li","q.li@unimelb.edu.au","N/A","N/A","No"]
[7630,null,"SJL/ASAM<MRI53426>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[3485,null,"C57BL/6-Cd8a<tm1Mak>",null,"Recessive","CD8 antigen, alpha chain","Cd8a","Unknown","Ly-2, Ly-35, Ly-B, Lyt-2","MGI:88346","targeted mutation 1, Tak Mak","Cd8a<tm1Mak>","MGI:1857149","6",{"$nulls":15},"Yes",{"$nulls":12},"Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens. CD8-positive T cells are absent resulting in an increased susceptibility to viral infection. There is also demyelination of the nerve cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,"WEHI","656","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5122,"Sox10LacZ","C57BL/6-Sox10<tm1Weg>",null,"Dominant","SRY-box containing gene 10","Sox10","Nil","Sox21","MGI:98358","SRY-box containing gene 10; targeted mutation 1, Michael Wegner","Sox10<tm1Weg>","MGI:2151173","15",{"$nulls":28},"lacZ is expressed by all Sox10-expressing cells","lacZ is expressed by all Sox10-expressing cells","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-05-12",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[7631,null,"SJL/ASAM<MRI26140>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",53,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5657,"C5L2 x C5aR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5658,"C8 (C8 Brca1 Co/Co)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[2774,"BALB/c.hK14-FLII 36","BALB/c-Tg(hK14-FLII)36/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT BALB/c","No","2008-02-16","Cryopreserved sperm",150,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[5120,"endothelin-3+/-","B6.129-Edn3<tm1Ywa>/J",null,"Recessive","endothelin 3","Edn3","Nil","114-CH19, 114CH19, tmgc48","MGI:95285","endothelin 3; targeted mutation 1, Masashi Yanagisawa","Edn3<tm1Ywa>","MGI:1857160","2",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality: mice have a mean life span of 21 days, with a range of 4-65 days.Variable body spotting: * extensive white spotting (70 - 80% of body surface) * white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs.Abnormal colon morphology: distal portion of colon narrow and spastic; proximal portion of colon distended.Aganglionic megacolon: absence of myenteric ganglion neurons in distal, spastic segment of colon.Absent enteric neurons: absence of myenteric ganglion neurons in distal, spastic segment of colon.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10",null,null,"No","2010-05-12",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[7527,"NOD.B6Idd11A","NOD.B6-Idd11<C57BL/6>/ArcApb",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes",{"$nulls":8},"insulin dependent diabetes susceptibility 11; C57BL/6","Idd11<C57BL/6>",null,"4",null,null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A",null,"No"]
[1758,"Apaf-1 knockout","C57BL/6-Apaf1<Gt(IRESBetageo)XIX18Pgr>",null,"Recessive","apoptotic peptidase activating factor 1","Apaf1","Nil","6230400I06Rik, Apaf1l","MGI:1306796","apoptotic peptidase activating factor 1; gene trap XIX18, Peter Gruss","Apaf1<Gt(IRESBetageo)XIX18Pgr>","MGI:1857868","10",{"$nulls":15},"No",{"$nulls":12},"Lethality throughout fetal growth and development: embryonic defects apparent by E12.5, die by E17.       Decreased apoptosis:* induction of apoptosis in mutant embryonic fibroblasts is similar to controls, but mutant fibroblasts show reduced cell death after prolonged treatment with apoptotic stimuli (anti-Fas antibody, C6-ceramide, and staurosporin).* tissues that normally exhibit apoptosis in developmental stages instead exhibit hyperplasia and/or overgrowth.Abnormal craniofacial bone morphology.Absent ethmoidal bone.Impaired ossification of basisphenoid bone.Absent neurocranium: absence of skull vault.Absent vomer bone.Cleft palate: late and imperfect palatial fusion occursMidline facial cleft.Nervous system phenotype: at E13-14 and E18, numbers of spinal motoneurons and dorsal root ganglion neurons are not different from wild-type.Abnormal brain morphology: brain hyperplasia presumably due to lack of apoptosis in the mantle layer of the developing diencephalon, midbrain, cerebellum and ventricular layer of the choroid plexus of the fourth ventricle; an excess of differentiating neurons is observed in these locations.Abnormal brain development.Abnormal embryonic neuroepithelial layer differentiation: overgrowth resulting in abnormal folding and generation of a mantle layer.Abnormal cortical marginal zone morphology.Abnormal folding of telencephalic vesicles: may be due to intense overgrowth (hyperplasia) of diencephalon and midbrain.Small telencephalic vesicles: may be due to intense overgrowth (hyperplasia) of diencephalon and midbrain.Exencephaly.Hydroencephaly: results from obliteration of the lumen of the neural tube.Choroid plexus hyperplasia: hyperplasia of the choroid plexus of the fourth ventricle is seen.Hypothalamus hyperplasia: abnormal overgrowth of ventral side of hypothalamus through the base of the skull.Diencephalon hyperplasia.Midbrain hyperplasia.Abnormal neuron morphology: at E14 and E18, motoneurons and DRG neurons exhibit degenerative-like changes not seen in wild-type.Abnormal neuron physiology: at E14, developing neurons undergo atypical programmed cell death (PCD) in contrast to type 1 (apoptotic-like) mechanism exhibited in wild-type neurons; apoptotic-like degeneration markers (such as TUNEL labeling) are not observed in dying mutant neurons.Abnormal lens polarity.Small lens.Persistence of hyaloid capillary system: eye vascular endothelial cells obliterate the optic cup at E14.5.Retina hyperplasia:* by E12.5, the retina is noticeably thicker* by E14.5, the hyperplastic retina fills the optic cup and is folded.Interdigital webbing: interdigital webbing in limb buds with reduced apoptosis.Abnormal craniofacial bone morphology.Absent ethmoidal bone.Impaired ossification of basisphenoid bone.Absent neurocranium: absence of skull vault.Absent vomer bone.Cleft palate: late and imperfect palatial fusion occursAbnormal embryonic neuroepithelial layer differentiation: overgrowth resulting in abnormal folding and generation of a mantle layer.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #314","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6651,"RBC13","C;B6-Hbb-b1<Rbc13>/WehiMarpApb",null,"Dominant","Hbb-b1  hemoglobin, beta adult major chain","Hbb-b1","Reduced","beta maj, beta major globin, beta1, beta-s","MGI:96021","hemoglobin, beta adult major chain; red blood cell mutant 13","Hbb-b1<Rbc13>","MGI:5460881","7",{"$nulls":28},"Lethal at E18.5 or just after (not present at birth). Embryos are normal until E16.5 where they manifest progressive pallor and reduced fetal liver cellularity.","Microcytic, hypochromic anemia with severe reticulocytosis. Compensatory erythropoiesis with splenic extramedullary hematopoiesis due to red cell destruction. ","C57BL/6 and BALB/c","No","No","Yes","No","No","Yes","No","Excellent",null,null,"Heterozygote intercross and background strain wild type to heterozygote","No","2011-11-28","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Fiona","Brown","Monash University","fiona.brown2@monash.edu",{"$nulls":3},"Fiona","Brown","fiona.brown2@monash.edu","0810865","340/2002","No"]
[7669,"ENU31:G1","ANU:ENU31:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-05-02","Cryopreserved sperm",3829,20,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[5661,"Cardiac Cre ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[1837,"B-CK","B6.129-Ckb<tm1Bew>/Wehi",null,"Recessive","creatine kinase, brain","Ckb","Nil","B-CK, Ck-3","MGI:88407","targeted mutation 1, Be Wieringa","Ckb<tm1Bew>","MGI:3042843","12",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mice have abnormal hippocampal morphology with enlarged mossy fiber field size and display resistance to pharmacologically induced seizures, reduced habituation and spatial learning impairments and are slightly smaller than wildtype littermates.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08",null,0,0,null,"WEHI #1120","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1848,null,"B6.C3-Tg(APPswe,PSEN1dE9)85Dbo",null,"Dominant",{"$nulls":25},"transgene insertion 85, David R Borchelt","Each transgene controlled by mouse prion promoter.",{"$nulls":11},"Cerebral amyloid angiopathy:* exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months* amyloid deposition is observed in leptomeningeal vasculature.Amyloid beta deposits:* sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks.* deposits are more extensive in females.* level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age.* senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age.* plaques are restricted to cortex and hippocampus at time points up to 12 months of age.* plaques increase in number and size over time.* exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months.* insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control.* total amyloid beta levels are increased by 3.6 fold in sucrose fed mice.* amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice.Increased drinking behavior: mice fed sucrose water exhibited increased water consumption.Abnormal spatial learning* transgenic mice fed sucrose water failed to learn Morris water maze test after 5 days of training.* water-fed transgenic mice retained some learning ability over 5 day test period, but did not perform as well in the water maze test as non-transgenic controls.Increased circulating insulin level: fasting plasma insulin levels are increased 3 fold in mice fed sucrose water as compared to water-fed control.Increased circulating cholesterol level: total cholesterol, but not HDL, levels are increased 30% in mice fed sucrose water as compared to water-fed control.Increased circulating triglyceride level: elevated plasma triglyceride levels observed in females at 15 weeks of age.Impaired glucose tolerance: mice fed sucrose water displayed an impaired glucose tolerance as compared to water-fed controlcardiovascular system.Vasculature congestion.Increased body weight:* mice fed sucrose water consistently gained weight over study time period (2 months- 8 months).* sucrose-fed mice increased body weight by 17% over water-fed controls.","C57BL/6 x C3H","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1270","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1849,null,"B6.129-Tnfrsf1a<tm1Mak>/JWehi",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Nil","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","targeted mutation 1, Tak Mak","Tnfrsf1a<tm1Mak>","MGI:1857261","6",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1293","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7632,null,"SJL/ASAM<MRI41948>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07",null,0,0,null,null,"true",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5339,null,"C57BL/6-Tg(CAG-ATP7A)22Jmer/Apb",null,"Dominant",{"$nulls":25},"human ATPase, Cu++ transporting, alpha polypeptide","chicken beta-actin",{"$nulls":10},"The overall phenotype of transgenic mice was normal, and the transgene was transmissible to progeny, but the transgenic mice showed interesting changes in Cu concentration in various organs that were generally consistent with a role for ATP7A in efflux.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9",null,null,"No","2010-12-11","Cryopreserved sperm",40,0,null,null,"false",null,"Julian","Mercer","Deakin University","julian.mercer@deakin.edu.au",{"$nulls":3},"Roxana","Llanos","roxana.llanos@deakin.edu.au","N/A","N/A","No"]
[5666,"Cav-1 WT",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5189,null,"ENU18WT:007a",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm",20,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[6630,"ABKO","B6.129X1-Adra1a<tm1Pcs>",null,"Recessive","Adra1a","adrenergic receptor, alpha 1a","Nil","Adra1c","MGI:104773","adrenergic receptor, alpha 1a; targeted mutation 1, Paul C Simpson","Adra1a<tm1Pcs>","MGI:2387663","14",{"$nulls":28},"Decreased vasoconstriction: homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone.Decreased heart rate variability: by ECG telemetry, conscious homozygotes show a 14% reduction in basal heart rate variability, suggesting increased sympathetic balance.Hypotension: * by tail cuff manometer and arterial catheter, conscious homozygotes are hypotensive at rest, with a ~10-15 mm Hg reduction in blood pressure (8-12% of wild-type mice) * tail cuff pressure is also reduced in a smaller cohort of homozygotes in the C57BL/6 background whereas heart rate is slightly but not significantly higher relative to wild-type mice * no differences in body weight, heart weight, heart histology, blood chemistry, blood cell counts, cardiac output or renal function are observed.","Hypotension: heterozygotes are intermediately hypotensive relative to wild-type and homozygous mutant mice","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[5340,"CTR1 Tg","C57BL/6-Tg(SLC31A1)Jmer",null,"Dominant",{"$nulls":25},"human Solute carrier family 31, member 1",{"$nulls":13},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-12-11",null,0,0,null,null,"true",null,"Julian","Mercer","Deakin University","julian.mercer@deakin.edu.au",{"$nulls":3},"Roxana","Llanos","roxana.llanos@deakin.edu.au","N/A","N/A","No"]
[7636,null,"SJL/ASAM<MRI33532>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",61,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7637,null,"SJL/ASAM<MRI47455>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",55,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7639,null,"SJL/ASAM<MRI135658>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7641,null,"SJL/ASAM<MRI58173>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[1859,"Eµ-myc/Bad ko","Un-Tg(IghMyc)22Bri Bad<tm1Sjk>/Wehi",null,"Dominant","BCL2-associated agonist of cell death","Bad","Nil","Bbc2","MGI:1096330","BCL2-associated agonist of cell death; targeted mutation 1, Stanley J Korsmeyer","Bad<tm1Sjk>","MGI:2675966","19",{"$nulls":15},"Yes","transgene insertion 22, Ralph L Brinster","Lymphoid-specific immunoglobulin heavy chain enhancer (Eμ)","B cell lineage",{"$nulls":9},"Excess pre-B cells in bone marrow. Animals develop high incidence pre-B and B lymphoma - Adult mortality: 80% More than 90% of Emu-myc mice die between 6 and 18 weeks of age (median 11 weeeks). Enlargement of all lymph nodes, spleen, infiltration of thymus (thymoma), bone marrow, liver, lung, weight loss.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1850","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3944,"Line3","FVB/N-Tg(HBA1-GFP)3EW","FVB/N-Tg(HBA1-GFP)3EW","Dominant",{"$nulls":25},"Green Fluorescent Protein","α-Globin (-570 to +37) (4.1kb of enhancer)",{"$nulls":10},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2008-10-17",null,0,0,null,null,"true",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whielaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[7642,null,"SJL/ASAM<MRI132482>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07",null,0,0,null,null,"true",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5673,"CD11c-DTR/GFP x C57 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5447,"Minnie ; ENU12NIH 71b CBA","ENU12NIH:071b CBA",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Small Mice","Normal","C57BL/6JAnu x CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","N/A","2","Sib x sib","No","2011-02-28","Cryopreserved sperm",40,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[5674,"CD11cDTR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7638,null,"SJL/ASAM<MRI132159>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",20,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7640,null,"SJL/ASAM<MRI130367>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays a slight growth retardation phenotype for a week.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",22,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5163,"FVB x FVB.B6; Dirc-1","FVB/N;B6-Dircq1<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":37},"As per parental strain.Once injected with Alloxan mice are resistant to becoming diabetic (check via urine glucose or blood monitor), these mice do not show nephropathy and retinopathy disease consistent with the human conditions as compared to the B6;FVB/N-Dirc-1<FVB/N> strain. ","As per parental strain.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2010-06-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A","N/A","No"]
[7645,null,"B6/Mrit-114906","B6/Mrit-114906","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07",null,0,0,null,null,"true",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[6631,"ABKO","B6.129P2-Adra1b<tm1Cta>",null,"Recessive","adrenergic receptor, alpha 1b","Adra1b","Nil","alpha1B-adrenergic receptor","MGI:104774","adrenergic receptor, alpha 1b; targeted mutation 1, Susanna Cotecchia","Adra1b<tm1Cta>","MGI:2148638","11",{"$nulls":28},"Abnormal heart left ventricle morphology: left ventricular volume is higher.Decreased vasoconstriction: exhibit a reduction in mesenteric vascular responses to endogenous norepinephrine compared to wild-type, indicating reduced vasoconstriction in response to norepinephrine.Decreased cardiac muscle contractility: * phenylephrine-induced contractions of aortic rings are decreased by 25%. * baseline myocardial contractility is lower, as reflected by dP/dt. * transient bilateral carotid occlusion results in a minimal increase in myocardial contractility instead of the enhanced contractility seen in wild-type.Decreased heart rate: transient bilateral carotid occlusion results in a decrease in heart rate compared to a slight increase in treated wild-type, however baseline heart rate is normal.Abnormal systemic arterial blood pressure: * mean arterial blood pressure response to phenylephrine is decreased by 45% * mean arterial blood pressure response to norepinephrine is also decreased although to a lesser extent than seen with phenylephrine.Decreased systemic arterial blood pressure: exhibit impaired pressor response to a hypotensive stimulus, with marked attenuation in the change in systolic blood pressure and in the percent change in the end-systolic pressure-volume relationship after transient bilateral carotid occlusion.Decreased systemic arterial systolic blood pressure: baseline systolic blood pressure and Ea are lower.Impaired passive avoidance behaviour: 4-5 month old homozygotes show impaired retention of an inhibitory avoidance task after receiving a stressful electric stimuli.Decreased exploration in new environment: 4-5 month old homozygotes show significantly reduced horizontal exploratory activity and a reduced rearing behavior (vertical activity) in the open field.Abnormal baroreceptor physiology: transient bilateral carotid occlusion to test cardiovascular responses to a hypotensive stimuli produced an attenuated pressor response, indicating an abnormal baroreflex activity.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[6927,"ENU18:::B6:G1","ANU:ENU18:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm",3067,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41   ",null,"No"]
[7373,"ATARI:kk:Cbl-bKO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> H2<k> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) ","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Ptsn>","MGI:2182940","10",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":11},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sib x sib","No","2013-07-08","Cryopreserved sperm",20,0,"ANU","217","false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[7373,"ATARI:kk:Cbl-bKO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> H2<k> Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb",null,"Cbl-b","MGI:2146430","Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":16},"transgene insertion 1, Mark M Davis",{"$nulls":41},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A"]
[6929,"ENU20:G1","ANU:ENU20:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm",394,40,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[5164,"B6 x B6FVB; Dirc-1","B6;FVB/N-Dircq1<FVB/N>/ArcApb",null,"Dominant",{"$nulls":33},"diabetes induced renal changes 1","Dircq1",null,"6","As per parental strain.Once injected with Alloxan mice become diabetic (check via urine glucose or blood monitor), these mice show nephropathy and retinopathy disease consistent with the human conditions.  Mice are identified by conventional genotyping but on induction of diabetes phenotypes relating to type 1 diabetic complication are observed i.e. Excessive urination, weight loss and proteinuria. ","As per parental strain.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2010-06-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A","N/A","No"]
[6928,"ENU19:G1","ANU:ENU19:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm",471,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[5166,"Idd5","NOD.B6-Idd5<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":37},"As per the parental strain (NOD/Lt).Delayed onset of Type 1 diabetes.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2010-06-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A","N/A","No"]
[4102,null,"KRN:231",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"4",null,"No","2008-12-04","Cryopreserved sperm",100,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[32,"B-thy","C57BL/6JSfdAnu-Trp53<Bhy>/AnuApb","C57BL/6JSfdAnu-Trp53<Bhy>/AnuApb","Semi-dominant","transformation related protein 53","Trp53","Nil","p53","MGI:98834","bthy","Trp53<Bhy>","MGI:3611889","11","ENSMUSG00000059552","ENSMUST00000108658","Trp53-201","412","540","T to C","ENSMUSE00000111826","5","138","Cysteine to Arginine",{"$nulls":4},"ATAAGCTATTCTGCCAGCTGGCGAAGACGTGCCCTGTGCAGTTGTGGGTCAGCGCCACACC","No",{"$nulls":13},"primitive hematopoietic or T cell leukemia,Sudden death,hemorrhage,Thymic lymphomaFibrosarcomaMultinodal lymphomaOsteosarcomaHaemangiosarcomaBrain tumourTeratocarcinoma","C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm",27,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[141,"Pebbles ; DD6","C57BL/6JSfdAnu-Tg(IghelD4)Ccg/AnuApb",null,"Dominant",{"$nulls":25},"IgD-only, anti-HEL H+L chain",null,"low level",{"$nulls":9},"Mice express IgD immunoglobulin reactive to Hen Egg lysozyme",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",20,0,"ANU","180","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[7646,null,"B6/Mrit-107292","B6/Mrit-107292","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07",null,0,0,null,null,"true",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5452,"PD","B6;129/Sv-Eif2ak2<tm1Cwe>/MarpApb",null,"Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Nil","dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449","eukaryotic translation initiation factor 2-alpha kinase 2; targeted mutation 1, Charles Weissmann","Eif2ak2<tm1Cwe>","MGI:2182566","17",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-02","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Bryan","Williams","MIMR-PHI Institute of Medical Research","bryan.williams@monash.edu","MIMR, Monash Medical Centre, 246 Clayton Road","Clayton","Victoria","Anthony","Sadler","Anthony.Sadler@monash.edu","MMCA 2007/42","N/A","No"]
[7647,null,"B6/Mrit-amp","B6/Mrit-amp","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/017",null,"No"]
[4111,null,"KRN:172",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",10,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[6926,null,"c-mycδKI",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Unknown","1500006F24Rik, Bim, Bod","MGI:1197519",{"$nulls":3},"2",{"$nulls":28},"Unknown","Unknown","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-06-29","Cryopreserved sperm",60,0,null,null,"true",null,"Hamsa","Puthalakath","La Trobe University","h.puthalakath@latrobe.edu.au",{"$nulls":3},"Hamsa","Puthalakath","h.puthalakath@latrobe.edu.au","AEC11-47","GMSC 11-12","No"]
[5684,"Chat tm1(cre/ERT)Nat /J",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5685,"ChAT-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7650,null,"B6/Mrit-da","B6/Mrit-da","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a transient growth decrease","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-04-07","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/017",null,"No"]
[5437,"Gq KO","B6.129-Gnaq<tm1>/Apb",null,"Semi-dominant","guanine nucleotide binding protein, alpha q polypeptide","Gnaq","Nil","Dsk1, Dsk10, G alpha q, Galphaq, Gq, GqI","MGI:95776",{"$nulls":3},"19",{"$nulls":28},"Small agouti mouse, gold stomach, black eyes and extremeties.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","6",null,null,"No","2011-02-16","Cryopreserved sperm",50,0,null,null,"false",null,"Sharelle","Sturgeon","Monash University","sharelle.sturgeon@monash.edu",{"$nulls":3},"Sharelle","Sturgeon","sharelle.sturgeon@monash.edu","E/0569/2007/M","E21/02","No"]
[6632,"Kit1","C57BL/6-Tg(Myh6-kit)1.1",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[4436,null,"C57BL/6-Tg(PDHA2-eGFP-MAP2cN)",null,"Recessive",{"$nulls":25},"Enhanced green fluorescent protein (GFP) fused to microtubule-associated protein 2 (human) (EGFP-MAP2cN)","pyruvate dehydrogenase E1 alpha 2 (PDHA2)",{"$nulls":10},"Appears to be infertile",null,null,"Yes","Yes","Yes","No","No","No","No","Poor",{"$nulls":3},"No","2009-02-17","Cryopreserved sperm",18,0,null,null,"true",null,"Kate","Loveland","Monash University","kate.loveland@med.monash.edu.au",{"$nulls":3},"Kate","Loveland","kate.loveland@med.monash.edu.au","N/A","N/A","No"]
[7579,"Spi6 KO x OT-I","C57BL/6J-SerpinB9<tm1.1PIB> Tg(TcraTcrb)1100Mjb/MarpApb",null,"Dominant","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9","Nil","PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","MGI:3054907",{"$nulls":10},"Increased apoptosis:• apoptosis is increased in LCMV- and LM-specific CTLs in mutantsAbnormal CD8-positive, alpha-beta cytotoxic T cell morphology:• upon infection with LCMV Armstrong or a strain of Listeria monocytogenes (LM), numbers of LCMV-specific CTLs are reduced 5-fold and LM-specific CTLs are reduced 9-fold compared to control B6 mice.• frequency of CTLs devoid of Gzmb granules is 3 times greater than in controls; number of Gzmb granules per CTL is 2-fold lower than in controls.Abnormal cytotoxic T cell physiology:• apoptosis is increased in LCMV- and LM-specific CTLs in mutants.Defective cytotoxic T cell cytolysis:• deficit in CTL activity is observed in ex vivo activity assay over course of LCMV infection; on day 10, activity is decrease 6-fold compared to controls.Abnormal enzyme/ coenzyme level:• caspase 3 in cytoplasm is increased.Abnormal enzyme/coenzyme activity:• GranzymeB activity is significantly increased in cytoplasm of mutants compared to controls.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Spi6 KO mice mated with  OT-I mice","No","2014-01-28","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Monica","Prakash","Monash University","monica.prakash@monash.edu",{"$nulls":3},"Phillip","Bird","phil.bird@monash.edu","SOBS/B/2009/35/BC","PC2","No"]
[6633,"Kit2","C57BL/6-Tg(Myh6-kit)1.2",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[4771,"c-cbl KO","C57BL/6-Cbl<tm1Ddlb> ",null,"Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2009-07-28",null,0,0,null,null,"true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":6},"AEC","N/A","No"]
[4829,"6AT:35","ENU6AT:035",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",60,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[207,"Tbx20 floxed","Tbx20<tm1Rph>",null,"Recessive","T-box 20","Tbx20","Nil","Tbx12","MGI:1888496","targeted mutation 1, Richard P Harvey","Tbx20<tm1Rph>","MGI:3579478","9",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[7273,"ENU20 017b ; ENU20:017b","C57BL/6NCrlAnu-Dock2<m3Anu>/AnuApb","C57BL/6NCrlAnu-Dock2<m3Anu>/AnuApb","Recessive","dedicator of cyto-kinesis 2","Dock2","Unknown","CED-5, Hch, MBC ","MGI:2149010","dedicator of cyto-kinesis 2; mutation 3, The Australian National University","Dock2<m3Anu>","MGI:5563488","11","ENSMUSG00000020143","ENSMUST00000093193","Dock2-001","3921","3990","T to A","ENSMUSE00000351317","39","1307","Tyrosine to STOP",{"$nulls":4},"AGCCTGTGCAAGGAACTGGCGGAACAATATGAGATGGAGATCTTTGACTACGAGCTACTCA",{"$nulls":13},"Decreased CD4<+> T cells. Increased CD44<hi> expression in CD4 and CD8 T cells.","Normal","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","0","G6","Het x Het","No","2013-02-12","Cryopreserved sperm",25,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","A2011/41",null,"No"]
[2775,null,"C57BL/6-Tg(hK14-FLII)36",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT C57BL/6","No","2008-02-16",null,0,0,null,null,"true",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[1360,null,"NOD.B6 Idd3r450",null,"Dominant","insulin dependent diabetes susceptibility 3","Idd3","Unknown","Idd-3","MGI:96405",{"$nulls":3},"3",{"$nulls":15},"Yes",{"$nulls":12},"Idd3 is a diabetes susceptibility QTL mapping to a 145 kb interval on mouse Chromosome 3 around 19.2 cM. Il2 colocalizes with Idd3 and has been suggested as a candidate gene.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22",null,0,0,null,null,"true",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au",{"$nulls":3},"Cecile","King","c.king@garvan.org.au","N/A","N/A","No"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Unknown","pRb, Rb, Rb-1","MGI:97874","targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":15},"Yes",{"$nulls":12},"Compound mutant: Mild anaemia.  Single Epo-R-Cre – lethal as homozygous, heterozygous maintained only.  Single pRbfl/fl – no phenotype until Cre exposedeYFP reporter for tracking of deleted cells in vivo","heterozygous mice are normal, viable and non-anaemic (only pRbfl/fl are anaemic)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","5",null,"Epor<tm1(EGFP/cre)Uk> -ve  Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj> female x Epor<tm1(EGFP/cre)Uk> +ve  Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj> het male","No","2014-02-14","Cryopreserved sperm",40,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC166","No"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","erythropoietin receptor","Epor","Unknown",null,"MGI:95408","erythropoietin receptor; targeted mutation 1, Ursula Klingmuller","Epor<tm1(EGFP/cre)Uk>","MGI:3052727","9",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC166"]
[7585,"Epo-R-Cre R26eYFPki/ki pRbfl/fl","B6.129-Epor<tm1(EGFP/cre)Uk> Gt(ROSA)26Sortm1(EYFP)Cos Rb1<tm3Tyj>/StvApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Increased","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC166"]
[1550,null,"BALB/c-Tg(iFABPp-TGFb1)  ",null,"Recessive",{"$nulls":25},"transforming growth factor, beta 1","at intestinal fatty acid binding protein (nucleotides -1178 - +28) - iFABP , i-FABP  linked to nucleotides 3–2,150 of the human growth hormone (hGH) gene (except for its 5' regulatory sequences).","high",{"$nulls":9},"Restricted expression of TGF beta transgene to intestine - duodenum and proximal jejunum.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",150,0,null,"ABS #037","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor","Tnf","Normal","DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha","MGI:104798","targeted mutation 2, Jonathon D Sedgwick","Tnf<tm2Jods>","MGI:3578747","17",{"$nulls":15},"Yes","Neomycin resistance gene",{"$nulls":11},"Normal. Control of APB ID#2395",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",160,0,null,"ABS #016","true",null,"Geeta","Chaudhri","The Australian National University","geeta.chaudhri@anu.edu.au",{"$nulls":3},"Geeta","Chaudri","geeta.chaudri@anu.edu.au","A.BS.01.09","N/A","No"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Unknown","memTNF, memTNFdelta","MGI:1314884","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1a<tm1Imx>","MGI:1857468","Unknown",{"$nulls":58},"Geeta","Chaudri","geeta.chaudri@anu.edu.au","A.BS.01.09","N/A"]
[4782,"WT control","C57BL/6.Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx> WT control",null,"Recessive","tumor necrosis factor receptor superfamily, member 1b","Tnfrsf1b","Unknown","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314883","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1b<tm1Imx>","MGI:1860087","Unknown",{"$nulls":58},"Geeta","Chaudri","geeta.chaudri@anu.edu.au","A.BS.01.09","N/A"]
[6634,"Wv1","C57BL/6-Tg(Myh6-Kit<W-v>)2.1",null,"Dominant",{"$nulls":25},"myosin heavy chain 6 - c-kit<W-v>","myosin, heavy polypeptide 6, cardiac muscle, alpha","Heart",{"$nulls":9},"Expression of c-kit(W-v> allele in heart tissue",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-10-20",null,0,0,"Victor Chang",null,"true",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","N/A","No"]
[638,"HtrA3-KO (MP10 Cre65)","C57BL/6-Htra3<tm1>",null,"Dominant","HtrA serine peptidase 3","Htra3","Nil","2210021K23Rik, 9530081K03Rik","MGI:1925808",{"$nulls":3},"5",{"$nulls":15},"Yes",{"$nulls":12},"Mice are fertile and do not show any clear signs of immunodeficiency.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-04-25","Cryopreserved sperm",55,0,null,null,"true",null,"Guiying","Nie","MIMR-PHI Institute of Medical Research","guiying.nie@princehenrys.org",{"$nulls":3},"Ms","Li","guiying.nie@princehenrys.org","N/A","N/A","No"]
[7068,"Momme D32","FVB/NJ-Dnmt1<MommeD32> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","DNA methyltransferase (cytosine-5) 1","Dnmt1","Unknown","Cxxc9, Dnmt1o, MommeD2, MTase","MGI:94912","MommeD33",null,null,"9",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD32<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-29","Cryopreserved sperm",39,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[208,"Tbx5 KO","Tbx5<tm1.1Jse>",null,"Recessive","T-box 5","Tbx5","Unknown",null,"MGI:102541","targeted mutation 1.1, Jonathan G Seidman","Tbx5<tm1.1Jse>","MGI:2387851","5",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal (do not survive past day E10.5), abnormal cardiac and forelimb development.  ","Model for Holt Oram Syndrome","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[4739,"Wink","C.129-Tg(hGM-CSFRb) Csf2rb<tm1Clsc> Csf2rb2<tm1Cgb>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Unknown","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":15},"Yes","human beta common chain receptor for GM-CSF/IL-3/IL-5","pgk","very low",{"$nulls":9},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10","0","Purchased BALB/c mated with transgenic mouse from colony to maintain colony","No","2009-04-20","Cryopreserved sperm",120,0,null,null,"false",null,"Hayley","Ramshaw","Hanson Institute","hayley.ramshaw@imvs.sa.gov.au",{"$nulls":3},"Hayley","Ramshaw","hayley.ramshaw@imvs.sa.gov.au","N/A","N/A","No"]
[4739,"Wink","C.129-Tg(hGM-CSFRb) Csf2rb<tm1Clsc> Csf2rb2<tm1Cgb>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)","Csf2rb2","Unknown","AIC2A, BetaIl3, Bil3, Il3r, Il3rb2","MGI:1339760","targeted mutation 1, C Glenn Begley","Csf2rb2<tm1Cgb>","MGI:3652583","15",{"$nulls":58},"Hayley","Ramshaw","hayley.ramshaw@imvs.sa.gov.au","N/A","N/A"]
[206,"Tbx20 KO","Tbx20<tm1.1Rph>",null,"Recessive","T-box 20","Tbx20","Nil","Tbx12","MGI:1888496","targeted mutation 1.1, Richard P Harvey","Tbx20<tm1.1Rph>","MGI:3579836","9",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethal ~E10.5.  Abnormal cardiac and yolk sac development.Failure of looping morphogenesis-looping is blocked.","None reported","C57BL/6 x 129","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[5687,"ChAT-EGFP x SOD1G93A",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6932,"Crim1FLOX","B6.129/Ola-Crim1<tm1>/Uqbr",null,"Recessive","cysteine rich transmembrane BMP regulator 1 (chordin like)","Crim1","Nil",null,"MGI:1354756","Crim1FLOX",null,null,"17",{"$nulls":28},"Normal","Normal","Predominantly C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",">6",null,null,"No","2012-07-05",null,0,0,"UQ",null,"true",null,"David","Pennisi","The University of Queensland","d.pennisi@uq.edu.au",{"$nulls":3},"David","Pennisi","d.pennisi@uq.edu.au","SBMS/051/11/NHMRC","IBC/205E/SBMS/2010","No"]
[221,"Chisel KO","C57BL/6-Smpx<tm1Rph>/Apb",null,"Recessive","small muscle protein, X-linked","Smpx","Unknown","chisel, Csl","MGI:1913356","targeted mutation 1, Richard P Harvey","Smpx<tm1Rph>","MGI:2387819","X",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for a null mutation do not exhibit defects in heart or skeletal muscle morphology or development","No reported phenotype","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm",45,0,null,null,"false",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[1937,null,"BALB/c.B6-IL13<tm2Anjm> Ccl11<tm1Mer>/AnuApb",null,"Recessive","interleukin 13","Il13","Unknown","Il-13","MGI:96541","targeted mutation 2, Andrew NJ McKenzie","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":15},"Yes",{"$nulls":14},"BALB/c ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-29","Cryopreserved sperm",150,0,"ANU","055","false",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[1937,null,"BALB/c.B6-IL13<tm2Anjm> Ccl11<tm1Mer>/AnuApb",null,"Recessive","small chemokine (C-C motif) ligand 11","Ccl11","Nil","eotaxin, Scya11","MGI:103576","chemokine (C-C motif) ligand 11; targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11",{"$nulls":58},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A"]
[5693,"CMV Cre (CreDel)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5136,"A9","C57BL/6-Tg(TcrbB3)8Cbn/CbnApb",null,"Dominant",{"$nulls":25},"transgene insertion TcrbB3, Francis R Carbone","Tcrb","More than 10 copies",{"$nulls":9},"The majority of CD8 T cells express the trangenic Vb5.2 T cell receptor.","As for homozygous.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"br","No","2010-05-26","Cryopreserved sperm",50,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","0911339","2009/091","Yes"]
[212,"Nkx2-5 Cre","B6.129-Nkx2-5<tm2(cre)Rph>",null,"Recessive","NK2 transcription factor related, locus 5 (Drosophila)","Nkx2-5","Normal","Csx, Csx, Nkx-2.5, Nkx2.5, tinman","MGI:97350","targeted mutation 2, Richard P Harvey","Nkx2-5<tm2(cre)Rph>","MGI:2448972","17",{"$nulls":15},"No","Cre Recombinase","Nkx2-5",{"$nulls":10},"Normal","Normal","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[6255,"B6 Caspase -2/9","B6.129-Casp2<tm1Vaux> Casp9<tm1Flv>",null,"Recessive","caspase 2","Casp2","Nil","Caspase-2, Ich-1, Nedd2","MGI:97295","caspase 2; targeted mutation 1, David L Vaux","Casp2<tm1Vaux>","MGI:3609949","6",{"$nulls":28},"Perinatal Abnormal brain development:*At E14.5 a majority of embryos display brain over-growth similar to that found in Casp9<tm1Flv> homozygotes.Abnormal T cell physiology:*Thymocytes grown in wildtype hosts have only 10-20% of the DEVD-ase activity of wildtype or thymocytes deficient for only caspase 2.Hematopoietic system phenotype:*Irradiated wildtype hosts reconstituted with E14.5 Casp2<tm1Vaux> Casp9<tm1Flv> double homozygous fetal liver develop normal thymocyte numbers and sub-populations with no thymocyte upregulation of caspases 1, 3, 6, 7, 8, or 9, normal B cell and T cell apoptosis in response to cytokine withdrawal, and normal T cell sensitivity to dexamethasone.*Dexamethasone induced apoptosis of T cells (grown in wildtype hosts from E14.5 fetal liver) is blocked by caspase inhibitors but not by calpain and cathepsin inhibitors.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","316","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6255,"B6 Caspase -2/9","B6.129-Casp2<tm1Vaux> Casp9<tm1Flv>",null,"Recessive","caspase 9","Casp9","Nil","Caspase-9, ICE-LAP6, Mch6","MGI:1277950","caspase 9; targeted mutation 1, Richard A Flavell","Casp9<tm1Flv>","MGI:2158755","4",{"$nulls":61},"N/A","N/A"]
[639,"Vav-rtTA","B6.129-Tg(Vav-rtTA)/Apb",null,"Dominant",{"$nulls":25},"reverse tetracycline transactivator","vav","haemopoietic specific expression",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","9","0",null,"No","2007-04-25","Cryopreserved sperm",40,0,null,null,"false",null,"Richard","D'Andrea","Child Health Research Institute","richard.dandrea@adelaide.edu.au",{"$nulls":3},"Anna","Brown","anna.brown@adelaide.edu.au","N/A","N/A","No"]
[29,"Babe","C57BL/6JSfdAnu-Agtpbp1<babe>/AnuApb","C57BL/6JSfdAnu-Agtpbp1<babe>/AnuApb","Recessive","ATP/GTP binding protein 1","Agtpbp1","Unknown","Nna1","MGI:2159437","ATP/GTP binding protein 1; babe","Agtpbp1<babe>","MGI:3847121","13","ENSMUSG00000021557","ENSMUST00000022040","Agtpbp1-201","2413","2543","C to T","ENSMUSE00000118960","19","804","Arginine to STOP",{"$nulls":4},"ACATTTGTTACTACAAAAATCACTTCTCACGAAGCTCAGTTGCCGCAGGCGGACAGAAGGG","No",{"$nulls":12},"Lethal dilute ataxia, weakness of the hindlimbs and mild uncoordination (ataxia) which is usually detectable at weaning.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"8",null,"No","2006-02-06","Cryopreserved sperm",37,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.04.06","N/A","No"]
[133,"Homer","B10.Cg-H2<k2> Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb","B10.Cg-H2<k2> Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb","Dominant",{"$nulls":25},"transgene insertion 1, Richard J Cornall","dopachrome tautomerase (Dct) ; Trp2, Tyrp2 ","Melanocyte specific","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k2 variant","H2<k2>","MGI:4936842","17","Mice develop a spontaneous autoimmune disease with striking similarity to human vitiligo vulgaris and Vogt-Koyanagi-Harada syndrome. ",null,"C57BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5",null,"No","2006-02-06","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[1532,null,"BALB/c-IL9<tm1Anjm>/AnuApb",null,"Recessive","interleukin 9","Il9","Nil","Il-9, P40","MGI:96563","targeted mutation 1, Andrew NJ McKenzie","IL9<tm1Anjm>","MGI:2656470","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mice are viable and show no overt phenotype, however when challenged, aspects of the inflammatory response are shown to be impaired.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2007-07-05","Cryopreserved sperm",160,0,"ANU","139","false",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[5400,"FVB x FVB.B6 ; Dirc-3","FVB/N;B6-Dircq3<C57BL/6>/ArcApb",null,"Dominant",{"$nulls":28},"Unknown","Unknown",{"$nulls":3},"diabetes induced renal changes 3","Dircq3",null,"6","As per parental strain.Once injected with Alloxan mice are resistant to becoming diabetic (check via urine glucose or blood monitor), these mice do not show nephropathy and retinopathy disease consistent with the human conditions as compared to the B6;FVB/N-Dirc-3<FVB/N> strain. ","As per parental strain.","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","5","Hom x Hom","No","2011-01-31","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[6264,"del 362","C57BL/6-Dnmt3l<tm1Scot>",null,"Dominant","DNA (cytosine-5-)-methyltransferase 3-like ","Dnmt3l","Nil","D6Ertd14e, ecat7","MGI:1859287","DNA (cytosine-5-)-methyltransferase 3-like; targeted mutation 1, Hamish S Scott","Dnmt3l<tm1Scot>","MGI:3574947","10",{"$nulls":28},"Abnormal seminiferous epithelium morphology:*The epithelium has a vacuolated appearance.Azoospermia:*Germ cells are lost through apoptosis and sloughing with many tubules containing only Sertoli cells.Arrest of male meiosis:*At P14 in first spermatogenic wave a build up of leptotene and zygotene spermatocytes is seen with no cells progressing beyond stage IV.*At P70 only leptotene spermatocytes and spermatogonia are present.*The pachytene synaptonemal complex is not seen.Small gonad:*Adults display severe hypogonadism.Infertility",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","298","true",null,"Sarah","Kinkel","Walter and Eliza Hall Institute of Medical Research","kinkel@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7616,"EphA2 Knockout , EphA2 Reporter","B6.129-Epha2<Gt(ROSABetageo)CN3Yiw>/QimrApb",null,"Recessive","Eph Receptor A2","EphA2",null,"Eck, Myk2, Sek2, Sek-2","MGI:95278","Eph receptor A2; gene trap CN3, Yoichiro Iwakura","Epha2<Gt(ROSABetageo)CN3Yiw>","MGI:2448472","4",{"$nulls":28},"Abnormal tail morphology:• abnormal blood vessel formation in the tailsAbnormal caudal vertebrae morphology:• ectopic tail vertebra formationShort tail:• varying degrees of short tails, first seen around E12.5-13.5Kinked tail:• 40% exhibit varying degrees of kinky tails, first seen around E12.5-13.5Abnormal axial mesoderm:• aberrant axial mesoderm formationAbnormal neural tube morphology/development:• the wall of the neural tube in tails is thickened and multi-layeredSplit notochord:• notochord is abnormally bifurcated at the caudal end between E11.5 and E12.5 and the bifurcated notochords are abnormally intertwined• notochordal cells are spread broadly into the tail budAbnormal neural tube morphology/development:• the wall of the neural tube in tails is thickened and multi-layeredAbnormal vascular development:• abnormal blood vessel formation in tails, with the number of blood vessels changed and larger vessel caliberskeletonabnormal caudal vertebrae morphology ( J:69393 )• ectopic tail vertebra formationAbnormal sclerotome morphology• ectopic slerotomes form at the caudal tail where the bifurcated notochords form","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,"Homozygous x Homozygous","No","2014-03-07","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Andrew","Boyd","Queensland Institute of Medical Research","Andrew.Boyd@qimrberghofer.edu.au",{"$nulls":3},"Kirrilee","Beckett","Kirrilee.Beckett@qimrberghofer.edu.au","474","1891","No"]
[6933,"ENU19 WT:001:b:B6:G3","ANU:ENU19WT:001:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",58,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"APF2011/41",null,"No"]
[145,"RAMA:Hamlet","C57BL/6JSfdAnu-Tg(H2-sHEL)Ccg Tg(IghelMD4)4Ccg/AnuApb","C57BL/6JSfdAnu-Tg(H2-sHEL)Ccg Tg(IghelMD4)4Ccg/AnuApb","Recessive",{"$nulls":25},"soluble Hen Egg Lysozyme dimeric molecule","H-2k","Low",{"$nulls":11},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"13",null,"No","2006-02-06","Cryopreserved sperm",99,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.21.08","N/A","No"]
[{"$nulls":30},"transgene insertion 4, Christopher C Goodnow"]
[4831,"6CAT:004","ENU6CAT:004",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[6934,"ENU19 WT:002:b:B6:G3","ANU:ENU19WT:002:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6935,"ENU19 WT:005:b:B6:G3","ANU:ENU19WT:005:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",20,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6937,"ENU19 WT:008:b:B6:G3","ANU:ENU19WT:008:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7670,"ENU31:G2","ANU:ENU31:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-05-02","Cryopreserved sperm",4383,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[1953,"PDGFRa floxed","Un-Pdgfra<tm8Sor>",null,"Recessive","platelet derived growth factor receptor, alpha polypeptide","Pdgfra","Normal","CD140a, Pdgfr-2","MGI:97530","targeted mutation 8, Philippe Soriano","Pdgfra<tm8Sor>","MGI:2449440","5",{"$nulls":15},"Yes",{"$nulls":12},"Normal",null,"129S4","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-03",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7628,"EphA1 Knockout","B6.129-Epha1<tm1Sld>/QimrApb",null,"Recessive","Eph receptor A1","Epha1",null,"5730453L17Rik, Eph, Esk","MGI:107381","Eph receptor A1; targeted mutation 1, Shannon L Duffy","Epha1<tm1Sld>","MGI:3822370","6",{"$nulls":28},"A Homozygous (PLAP/PLAP) mouse will result in the normal phenotype displaying PLAP activity however EphA1 expression will be lost.Endometrium inflammation:\t• mice exhibit endometrium inflammation secondary to hydrometrocolpos.Vaginal inflammation:• mice exhibit inflammation of the vaginal mucosa secondary to hydrometrocolpos.Dilated uterine horn:\t• mice exhibit dilated, attenuated uterine horns secondary to hydrometrocolpos.Enlarged uterus:• mice exhibit an enlarged uterus due to an accumulation of clear uterine fluid (hydrometrocolpos).Increased uterus weight.Vagina atresia:• 18% of mice exhibit a failure of vaginal opening.• despite normal estrogen receptor expression, beta-estradiol treatment fails to induce precocious vaginal opening in P12 mice unlike in wild-type mice and vaginal opening can not be induced by likewise treating affected adult mice.Hydrometrocolpos:\t• mice exhibit inflammation of the vaginal mucosa and endometrium with dilated, attenuated uterine horns secondary to hydrometrocolpos.Female infertility:\t• female mice affected by hydrometrocolpos are sterile.Kinked tail:• up to 80% of mice exhibit a kinky tail due to incorrectly positioned caudal vertebrae.Distended abdomen: • in some mice due to an enlarged uterusAbnormal response/metabolism to endogenous compounds:• treatment with beta-estradiol fails to induce apoptosis in the lower genital tract and precocious vaginal opening unlike in wild-type mice.Skeleton phenotype: • despite a kinky tail, mice exhibit normal skeletal morphology.","Normal PLAP activity with EphA1 expression.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,null,"No","2014-04-04","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Andrew","Boyd","Queensland Institute of Medical Research","Andrew.Boyd@qimrberghofer.edu.au",{"$nulls":3},"Kirrilee","Beckett","Kirrilee.Beckett@qimrberghofer.edu.au","132","1891","No"]
[5202,"Tmem26 conditional knockout","C57BL/6-Tmem26<tm1>/UqbrApb",null,"Recessive","Transmembrane protein 26","Tmem26","Nil",null,"MGI:2143537",{"$nulls":3},"10",{"$nulls":15},"Yes",{"$nulls":12},"Normal,ubiquitous deletion of floxed region also produces normal animals.","normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","2 crosses from founder mouse (derived from a C57 cell line) to C57 mice","approx. 7",null,"No","2010-08-06","Cryopreserved sperm",47,0,"UQ",null,"false",null,"Carol","Wicking","The University of Queensland","c.wicking@imb.uq.edu.au","IMB, QBP, 306 Carmody Rd, St Lucia","Brisbane","Qld","Liam","Town","l.town@imb.uq.edu.au","imb/580/08/PHD(NF)","IBC/506/IMB/2007","No"]
[6936,"ENU19 WT:007:b:B6:G3","ANU:ENU19WT:007:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",50,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[148,"NODScid","NOD;Cg-H2<k> Prkdc<scid>/AnuApb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":12},"SCID mutation prevents TCR and BCR rearrangements. This prevents maturation of B and T cells at very early stages of development. These mice, therefore lack, T and B cells in periphery. Please refer to MGI allele page for further information using the link above.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"19",null,"No","2006-02-06","Cryopreserved sperm",165,0,"ANU","091","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[1946,null,"BALB/c.B6-Gata1<tm6Sho> Il5<tm1Kopf>/AnuApb",null,"Recessive","GATA binding protein 1","Gata1","Unknown","Gata-1, Gf-1","MGI:95661","GATA binding protein 1; targeted mutation 6, Stuart Orkin","Gata1<tm6Sho>","MGI:3037864","X",{"$nulls":15},"Yes",{"$nulls":12},"No eosinophils",null,"BALB/c ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-01","Cryopreserved sperm",135,0,"ANU","073","false",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[1946,null,"BALB/c.B6-Gata1<tm6Sho> Il5<tm1Kopf>/AnuApb",null,"Recessive","interleukin 5","Il5","Unknown","IL-5","MGI:96557","targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11",{"$nulls":58},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A"]
[5516,"Gwendolin","B6.(Cg)-Gstp1/Gstp2<tm1Wolf>",null,"Recessive","glutathione S-transferase, pi 1","Gstp1","Nil","Gst p-1, GstpiB","MGI:95865","targeted mutation 1, C Roland Wolf","Gstp1/Gstp2<tm1Wolf>","MGI:3046099","19",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.  Studying allergic airway disease compared with allergic WT mice, eosinophilia, goblet cell hyperplasia, airway remodeling, lung resistance, and IL-5 were enhanced in allergic Gstp-null mice.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","6",null,null,"No","2011-06-01",null,0,0,"ANU","165","true",null,"Di","Webb","The Australian National University","dianne.webb@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5516,"Gwendolin","B6.(Cg)-Gstp1/Gstp2<tm1Wolf>",null,"Recessive","glutathione S-transferase, pi 2","Gstp2","Nil","Gst p-2, Gst-3, Gst3, GSTpiA","MGI:95864","glutathione S-transferase, pi 2; targeted mutation 1, C Roland Wolf","Gstp1/Gstp2<tm1Wolf>","MGI:3046101","19",{"$nulls":61},"N/A","N/A"]
[4085,null,"ENU7PMH:139, Metabolic Lean 3",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Low percentage of body fat when fed on a high fat diet.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm",40,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[2442,"Koy","C57BL/6JSfdAnu-Coro1a<koy>/Apb","C57BL/6JSfdAnu-Coro1a<koy>/Apb","Recessive","coronin, actin binding protein 1A","Coro1a","Reduced","Clabp, coronin 1, Lmb3, p57","MGI:1345961","coronin, actin binding protein 1A; koyaanisqatsi","Coro1a<koy>","MGI:3818509","7","ENSMUSG00000030707","ENSMUST00000106364","Coro1a-002","76","329","G to A","ENSMUSE00000202191","2","26","Glutamic acid to Lysine",{"$nulls":4},"GACAGCCAGCCAAGGCTGACCAGTGCTATGAGGATGTGCGCGTCTCACAAACCACTTGGGA","Yes",{"$nulls":12},"Mice have few peripheral blood CD4 or CD8 T cells. T cells are also reduced in spleen and LN. There is reduced transwell migration of thymocytes and naive mature T cells to SDF (CXCL12) or to ELC (CCL21). Elevated phalloidin staining (elevated F actin). Decreased CD4-positive T cell number: CD4+ T cell numbers in the periphery are significantly decreased about 5-fold.Decreased CD8-positive T cell number: CD8+ T cell numbers in the periphery are significantly decreased about 5-fold.Decreased thymocyte number: the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice.Abnormal T cell physiology:* in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12.* similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21.","Slight T cell deficit.","C57BL/6JStdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5",null,"No","2008-01-14","Cryopreserved sperm",185,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","N/A","N/A","No"]
[6938,"ENU19 WT:012:a:B6:G3","ANU:ENU19WT:012:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",18,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6466,"LSM16Δ","C57BL/6-Edc3<tm1(KOMP)Vlcg>Ausb ?",null,"Recessive","enhancer of mRNA decapping 3 homolog (S. cerevisiae)","Edc3","Nil","Lsm16, Yjdc","MGI:2142951","enhancer of mRNA decapping 3 homolog (S. cerevisiae); targeted mutation 1, Velocigene","Edc3<tm1(KOMP)Vlcg>","MGI:5292973","9",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","718","true",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6940,"ENU19 WT:014:a:B6:G3","ANU:ENU19WT:014:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[5701,"Crim1 Flox C57 R26R",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[1977,"SMAD1Δ","Swiss-Smad<tm1Rob>",null,"Recessive","MAD homolog 1 (Drosophila)","Smad1","Nil","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 1, Elizabeth J Robertson","Smad1<tm1Rob>","MGI:2155483","8",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality during organogenesis: homozygotes are present at the expected Mendelian ratios at E9.5 but die by E10.5.Abnormal embryogenesis/ development: homozygous mutant embryos are often abnormally positioned within the yolk sac.Incomplete embryo turning: at E9.5-E10.0, a subset of homozygotes exhibit incomplete embryo turning.Abnormal mesoderm development: at E7.0, homozygotes display extensive twisting of the newly formed mesoderm along the proximodistal axis.Decreased embryo size: homozygous mutant embryos are often smaller than wild-type embryos.Abnormal embryonic epiblast morphology: by E7.0, homozygotes display extensive twisting of the epiblast along the proximodistal axis.Disorganized embryonic tissue: homozygotes display severe distortion of the embryonic region.Abnormal extraembryonic tissue morphology.Abnormal allantois morphology:* at E8.0, homozygotes exhibit absence of a recognizable allantoic bud; only a small allantoic rudiment is observed at E8.5.* by E9.5, three allantois phenotypes are observed: a balloon-like structure with peripheral blood-filled vessels; a dense structure filled with compact mesenchyme and small blood-filled sacs; occasionally, an allantoic rudiment that fuses peripherally and non-uniformly with the chorionic surface of the placenta.Abnormal chorion morphology: at E8.5, homozygotes show overproliferation of chorionic tissue, as well as aberrant folding of the chorion within the exocoelomic cavity and defective proximal migration.Abnormal extraembryonic endoderm formation:* at E7.0, homozygotes exhibit a localized outpocketing of the visceral endoderm at the posterior embryonic/extraembryonic junction.* despite ruffling of the visceral endoderm at E8.0-E8.5, the emerging AP axis is symmetrical, headfolds and somites form, gross visceral yolk sac morphology and mesoderm appear normal, and the node is clearly defined.Abnormal placenta morphology: homozygotes fail to establish a functional placental connection.Abnormal chorioallantoic fusion: occasionally, an allantoic rudiment fuses peripherally and non-uniformly with the chorionic surface of the placenta.Abnormal umbilical cord morphology: homozygotes fail to form the umbilical connection to the placenta.Decreased primordial germ cell number:* at E8.5, homozygotes show a significant reduction in the number of primordial germ cells.* 6 of 14 (43%) have no PGCs, 5 of 14 (36%) have fewer than ten and 3 of 14 (21%) have less than 25.Distended pericardium: at E9.5-E10.0, a subset of homozygotes exhibit a distended pericardium.Decreased embryo size: homozygous mutant embryos are often smaller than wild-type embryos.Abnormal ventral body wall: at E9.5-E10.0, a subset of homozygotes exhibit delayed ventral closure.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1978,"Smad1f","Swiss-Smad1<tm2Rob>",null,"Dominant","MAD homolog 1 (Drosophila)","Smad1","Normal","Madh1, Madr1, Smad 1","MGI:109452","MAD homolog 1 (Drosophila); targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-09-04",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6939,"ENU19 WT:012:b:B6:G3","ANU:ENU19WT:012:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",50,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[277,null,"FVB-Tg(Myl1-Igf1)1Nros",null,"Recessive",{"$nulls":25},"transgene insertion 1, Naida Rosenthal","skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus","restricted to skeletal muscle",{"$nulls":9},"Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-1 transgenic models. Expression of GATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic of younger animals.",null,"FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-02",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[6269,"DO11-10","BALB/c-Tg(DO11.10)10Dlo",null,"Semi-dominant",{"$nulls":25},"transgene insertion 10, Dennis Y Loh",{"$nulls":11},"Decreased CD4-positive T cell number:*CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide.Decreased double-positive T cell number:*CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide.Abnormal thymus physiology:*20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes.*Apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas.*3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla.*Peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","126","true",null,"Louis","Schofield","Walter and Eliza Hall Institute of Medical Research","schofield@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6941,"ENU19 WT:018:a:B6:G3","ANU:ENU19WT:018:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6943,"ENU19 WT:019:a:B6:G3","ANU:ENU19WT:019:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",36,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[320,null,"B6.129-Rag1<tm1Mom>/Apb",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-04","Cryopreserved sperm",250,0,"ANU","086","true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","A.BS.01.09","N/A","No"]
[7698,"R26 WT-Hoxa1 ki","C57BL/6-Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"Semi-dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 3237, TaconicArtemis","Gt(ROSA)26Sor<tm3237(CAG-Hoxa1)Arte>",null,"6",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm",50,0,"St V",null,"true",null,"Louise","Purton","St Vincent's Institute","lpurton@svi.edu.au",{"$nulls":3},"Louise","Purton","lpurton@svi.edu.au","N/A","N/A","No"]
[5409,"NOD.IL-12KO","NOD/Lt-IL12b<tm1Jm>/ArcApb",null,"Recessive","interleukin 12b","Il12b","Unknown","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","interleukin 12b; targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":15},"Yes",{"$nulls":12},"Phenotype on NOD/Lt background is unknown to the APB.However, the phenotype on 129 x C57BL/6 is as follows:Decreased circulating interferon-gamma level:* serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls.Abnormal macrophage physiology:* fewer than expected macrophages in the dermis of carcinogen treated skin.Abnormal granulocyte physiology:* fewer than expected granulocytes in the dermis of carcinogen treated skin.Abnormal lymphocyte physiology:* lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased.Abnormal NK cell physiology:* mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls.Abnormal CD8-positive T cell physiology:* dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin.Decreased interleukin-17 secretion:* barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17.Increased susceptibility to bacterial infection:* vaccination does not produce a protective response to M. tuberculosis.Decreased susceptibility to type IV hypersensitivity reaction:* specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type.Decreased incidence of chemically-induced tumors:* resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol.* however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells.Abnormal CD4-positive T cell physiology:* 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type.* 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type.* draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2011-02-03","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[6312,"B6Noxa/339/Ova","Noxa X BIM 216 /Rip-mOva",{"$nulls":3},"  Noxa       Bim     RipmOVA  ",{"$nulls":35},"Increased numbers of lymphoid and myeloid cells. Spleen and lymph nodes are 2-3-fold bigger than in wt. Sternum is sticking out.  Bim-/- females are bad mothers and should not be used for breeding unless necessary.  Bim -/-:  blood - increased lymphocytes (B + T cells), granulocytes & monocytes. - decreased platelets - Increased serum Ig.  Thymus - fewer pre T cells.  Age 1 year - lymphadenopathy - 55% -/-, 35% +/- mice sick with kidney disease or cardiac infarction/vasculitis.  Fewer -/- females born. When born, often have poorly formed reproductive organs.  -/- have protruding sternum.  No phenotype with additional loss of noxa. ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2931","true",null,"Andreas","Strasser",{"$nulls":8},"N/A","N/A","No"]
[7701,"B3K506 Tcra/b","C57BL/6-Tg(CD2-Tcra, -Tcrb)506/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor alpha, T cell receptor beta","Human CD2",{"$nulls":10},"Transgenic mice express the rearranged B3K506 Va4.1 and Vβ8.1 chains using the human CD2 promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm",11,0,"ANU",null,"false",null,"Stephen","Daley","The Australian National University","stephen.daley@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7699,"YAe62 Tcrb","C57BL/6-Tg(CD2-Tcrb)62/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor beta","Human CD2",{"$nulls":10},"YAe62 β mice are biased toward creating TCRs reactive to IAb-3K and the related ligand IAb-P-1K.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm",11,0,"ANU",null,"false",null,"Stephen","Daley","The Australian National University","stephen.daley@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","immunoglobulin heavy chain complex","Igh",null,null,"MGI:96442","immunoglobulin heavy chain complex; targeted mutation 1, Robert Brink","Igh<tm1Rbr>","MGI:3800383","12",{"$nulls":15},"Yes","transgene insertion 1, Robert Brink",{"$nulls":11},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-02-13","Cryopreserved sperm",70,0,"ANU",null,"true",null,"Katrina","Randall","The Australian National University","katrina.randall@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","dedicator of cytokinesis 8","Dock8",null,"1200017A24Rik, 5830472H07Rik, A130095G14Rik","MGI:1921396","primurus","Dock8<pri>","MGI:3835421","19",{"$nulls":16},"nZEG EGFP",{"$nulls":44},"N/A","N/A"]
[7274,"Primurus:swHEL:HcLc:Ly5a x EGFP","C57BL/6-Dock8<pri> Igh<tm1Rbr> Ptprc<a> Tg(IgkHyHEL10)1Rbr Tg(nZeg EGFP)",null,"Dominant","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":61},"N/A","N/A"]
[7700,"B3K506 Tcrb","C57BL/6-Tg(CD2-Tcrb)506/AnuApb",null,"Recessive",{"$nulls":25},"T cell receptor beta","Human CD2",{"$nulls":10},"TCRβ Tg mice express the rearranged B3K506 Vβ8.1 chain using the human CD2 promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm",12,0,"ANU",null,"true",null,"Stephen","Daley","The Australian National University","stephen.daley@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6310,"NOD.scid","NOD.CB17-Prkdc<scid>/JWehi",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":28},"Increased circulating glucose level:*Following treatment with streptozotocin, mice exhibit increased glucose serum levels that can be restored to euglycemic levels by engraftment of human islet cells.*Following intraperitoneal injection of human peripheral blood mononuclear cells, 11 of 12 streptozotocin-treated mice engrafted with human islet cells exhibit increased glucose serum levels although not as high as pre-transplantation.Abnormal response to transplant:*While human islet engrafts in streptozotocin-treated mice appear normal after 4 weeks, subsequent injection of human peripheral blood mononuclear cells results in destructive infiltrate into the human islet graft site, inflammation, loss of engrafted islet beta cells, fibrosis, and necrosis after 3 weeks.*However, this rejection is not due to graft versus host disease.",null,"NOD/LtSz ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1172","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Nil","Cd79a, Ig alpha, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a<tm1(cre)Reth>","MGI:3687451","7",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1695","true",null,"Lynn","Corcoran","Walter and Eliza Hall Institute of Medical Research","corcoran@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","PR domain containing 1, with ZNF domain","Prdm1","Normal","Blimp-1, Blimp1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":61},"N/A","N/A"]
[6333,"STAT3/Blimp/Mb-1Cre","C57BL/6-Cd79a<tm1(cre)Reth> Prdm1<tm1Nutt> Stat3<tm1Vpo>",null,"Semi-dominant","signal transducer and activator of transcription 3","Stat3","Nil","1110034C02Rik, Aprf","MGI:103038","signal transducer and activator of transcription 3; targeted mutation 1, Valeria Poli","Stat3<tm1Vpo>","MGI:2384507","11",{"$nulls":61},"N/A","N/A"]
[4117,"Patchy","ENU12NIH:037a",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"White patch on underbelly. One mouse in G2 seen with white patch as well as curly tail.","White patch on underbelly. One mouse in G2 seen with white patch as well as curly tail.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",20,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jessica","Armstrong","jessica.armstrong@anu.edu.au","A.BS.01.09","N/A","No"]
[31,"Blobby","C57BL/6JSfdAnu-Alms1<bbb>/AnuApb","C57BL/6JSfdAnu-Alms1<bbb>/AnuApb","Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","blobby","Alms1<bbb>","MGI:3611799","6","ENSMUSG00000063810","ENSMUST00000072018","Alms1-001","6392","6507","T to A","ENSMUSE00000552223","10","2130","Leucine to STOP",{"$nulls":4},"TCTTCTTTCTGAAGGTCAGGATTATGAGTTAGAAGAGGTTCAGCATATACCTCAGTCATAC","No",{"$nulls":12},"Late onset obesity (apparent at 3-6 months).  Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss.",null,"C57BL/6JStdAnu","Yes","No","Yes","Yes","No","Yes","Yes","Poor",null,"10",null,"No","2006-02-06","Cryopreserved sperm",109,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[2368,"thiana","ENU5AT:149 ",null,"Recessive",null,null,"Unknown",null,null,"thiana",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",43,0,null,null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Anders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[2371,null,"ENU7B6:021",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",25,0,null,null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[2778,"BALB/c.hK14-FLII 5","BALB/c-Tg(hK14-FLII)5/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT BALB/c","No","2008-02-16","Cryopreserved sperm",130,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[4747,"Gelsolin KO ; Gen","STOCK Gsn<tm1Djk>/AnuApb",null,"Recessive","gelsolin","Gsn","Nil",null,"MGI:95851","targeted mutation 1, David J Kwiatkowski","Gsn<tm1Djk>","MGI:2179509","2",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development. Have defects in cell motility, as might be expected for a protein involved in cytoskeletal actin filament regulation.",null,"Unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2009-04-27","Cryopreserved sperm",170,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","R.MG.11.08","N/A","No"]
[6336,"Tbx1 BAC","Tbx1 BAC Transgenic",{"$nulls":3},"  Tbx1    ",{"$nulls":35},"May die suddenly.",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3631","true",null,"Anne","Voss",{"$nulls":8},"N/A","N/A","No"]
[2463,null,"B6.CBA-Tg(hGMCSF-2CK1)1236/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm",20,0,"ANU","190","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[6942,"ENU19 WT:018:b:B6:G3","ANU:ENU19WT:018:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[3323,"Metallic","ENU10B6:031 ",null,"Recessive",{"$nulls":37},"Silver / grey coat. Mice appear otherwise healthy and are able to breed.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"1",null,"No","2008-06-15","Cryopreserved sperm",45,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramanium","anusha.subramaniam@anu.edu.au","N/A","N/A","No"]
[2380,"Jaffa","ENU8B6:085",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Coat colour defect.Dluted coat colour.Irregular coat pigmentation.Affected mice are born with a brown-coloured coat. Mice appear healthy otherwise. ",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",90,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramanium","anusha.subramaniam@anu.edu.au","N/A","N/A","No"]
[2466,null,"B6.CBA-Tg(hGMCSF-2KB)63/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm",30,0,"ANU","189","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[2468,null,"B6.CBA-Tg(hGMCSF-KBM)498/AnuApb",null,"Dominant",{"$nulls":25},"human GMCSF (GM-CSF)","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm",30,0,"ANU","183","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[6337,"Tbx5 BAC","Tbx5 BAC Transgenic",{"$nulls":3},"  Tbx5    ",{"$nulls":35},"Phenotype does not differ from a wildtype of the same genetic background.",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3704","true",null,"Anne","Voss",{"$nulls":8},"N/A","N/A","No"]
[6340,"VAV-bcl-473","VAV-bcl-473",{"$nulls":3},"  bcl2       Bim    ",{"$nulls":35},"Vavbcl69: Excess B cells throughout life.  Develop glomerulonephritis, lymphoma and plasmacytoma Enlarged spleens Lymphadenopathy (more white blood cells), larger (2-3fold) spleen and lymph nodes  ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2241","true",null,"Andreas","Strasser",{"$nulls":8},"N/A","N/A","No"]
[6342,"MYC10/200VT","vav-Myc 10 x vav-Myc/CTTG-PU1.200",{"$nulls":3}," vav-myc     PU1       TTA    ",{"$nulls":35},"Tumour development  T/+ mice develop thymoma or sub-cutaneous tumours (hystiocytic sarcoma) with a median onset of 41 weeks. T/T mice develop thymoma with a median onset of 13 weeks.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3965","true",null,"Ross","Dickens",{"$nulls":8},"N/A","N/A","No"]
[4531,"TNAP-Cre","C.B6-Alpl<tm1(cre)Nagy>/AnuApb",null,"Recessive","alkaline phosphatase, liver/bone/kidney","Alpl","Nil","Akp-2, Akp2, TNSALP, TNAP","MGI:87983","targeted mutation 1, Andras Nagy","Alpl<tm1(cre)Nagy>","MGI:2177588","4",{"$nulls":15},"Yes","Cre recombinase","TNAP",{"$nulls":10},"Embryonic Lethal",null,"Balb/c x C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","8",null,null,"No","2009-02-27","Cryopreserved sperm",120,0,"ANU",null,"false",null,"Klaus","Matthaei","The Australian National University","klaus.matthaei@anu.edu.au",{"$nulls":3},"Klaus","Matthaei","klaus.mattaei@anu.edu.au","N/A","N/A","No"]
[5174,"Nehmet ; Maat ; ENU15China:011a","C57BL/6JAnu-Cd4<maat>/AnuApb","C57BL/6JAnu-Cd4<maat>/AnuApb","Recessive","CD4 antigen","Cd4","Unknown","L3T4, Ly-4","MGI:88335","Maat","Cd4<Maat>","MGI:4819382","6","ENSMUSG00000023274","ENSMUST00000024044","Cd4-001",{"$nulls":7},"124816702","8",null,null,"GAGGACTGGGACCCTCACGACTACTCTCCTTGTCCCTGGGCAGCGCCAGGCAGCACGAAT","Yes",{"$nulls":12},"Low CD4 expression and CD4<+> T cell numbers.High CD8<+> T cell numbers",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-07-08","Cryopreserved sperm",57,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Lisa","Miosge","lisa.miosge@anu.edu.au","N/A","N/A","No"]
[6350,"NPYGFP","B6.FVB-Tg(Npy-hrGFP)1LOWl/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Bradford B Lowell","Npy promoter",{"$nulls":10},"No abnormal phenotype detected:*Hemizygotes are viable and fertile.*When exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Npy gene.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2554","true",null,"Paul","Baldock","Garvan Institute","p.baldock@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[61,"PieBaldSeizures","ENU3strain:PieBaldSeizures",null,"Recessive",null,null,"Unknown",{"$nulls":5},"16",{"$nulls":15},"Yes",{"$nulls":12},"Mostly white coat with small black flecks and mottles (ie piebald). Eyes are black. Mice also show very subtle shaking/trembling but are otherwise healthy. Defect in melanisation. Seizures were seen in C57BL/6 background.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7",null,"No","2006-02-06","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.04.06","N/A","No"]
[5714,"CYP/FGF9",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4080,null,"ENU6PH:078",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[6944,"ENU19 WT:019:b:B6:G3","ANU:ENU19WT:019:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",90,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4081,null,"ENU6PH:094",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[1362,"IL21RΔ","C57BL/6.129-IL21r<tm1Wjl>",null,"Recessive","interleukin 21 receptor","Il21r","Nil","IL-21R","MGI:1890475","targeted mutation 1, Warren J Leonard","Il21r<tm1Wjl>","MGI:2446509","7",{"$nulls":15},"No",{"$nulls":12},"Although mice deficient in the receptor for IL-21 (IL-21R) have normal lymphoid development, after immunization, these animals have higher production of the immunoglobulin IgE, but lower IgG1, than wild-type animals.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-06-22",null,0,0,null,null,"true",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au",{"$nulls":3},"Cecile","King","c.king@garvan.org.au","N/A","N/A","No"]
[6388,"ML5TG","C57BL/6-Tg(ML5sHEL)5Ccg/AnuAusb","C57BL/6-Tg(ML5sHEL)5Ccg/AnuAusb","Dominant",{"$nulls":25},"transgene insertion 5, Christopher C Goodnow","mouse metallothionein I promoter",{"$nulls":10},"Abnormal B cell anergy:*Abnormally low levels of anti-hen egg lysozyme (HEL) antibodies are made in response to immunization with HEL.*50-fold lower levels of anti-HEL antibodies occur in response to immunization with HEL coupled with sheep red blood cells, which is a T cell-independent method of activating B cells.Abnormal circulating protein level:*Hen egg lysozyme (HEL) is found in circulation at a median level of 17.3 ng ml<-1>",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2601","true",null,"Robert","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6945,"ENU19 WT:021:b:B6:G3","ANU:ENU19WT:021:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",9,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7671,"ENU26:008:IL7R:B6:G5","C57BL/6NCrlAnu-Il7r<m1Anu>/AnuApb",null,"Recessive","interleukin 7 receptor","Il7r","Unknown","CD127, IL-7Ralpha, IL-7 receptor alpha chain","MGI:96562",{"$nulls":3},"15","ENSMUSG00000003882","ENSMUST00000003981","Il7r-201","166","300","T to G","ENSMUSE00000269798","2","56","Threonine to Proline",{"$nulls":4},"TGGAAGTGGATGGAAGTCAACATTTATTGACTTGTGCTTTTAATGACTCAGACATCAACAC",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-05-02","Cryopreserved sperm",55,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[4082,null,"ENU7PMH:036",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm",45,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[6186,"GP139A056","B6;129S1-Mpl<tm1Wsa>/Wehi",null,"Recessive","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, thrombopoietin receptor, TPO-R","MGI:97076","myeloproliferative leukemia virus oncogene; targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":28},"Thrombocytopenic but healthy.  Platelet deficiency and hematopoietic stem cell anomalies. Alexander et al. Deficiencies in progenitor cells of multiple hemopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. ",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2676","true",null,"Doug","Hilton","Walter and Eliza Hall Institute of Medical Research","hilton@wehi.edu.au",{"$nulls":3},"Elaine","Major","emajor@wehi.edu.au","N/A","N/A","No"]
[6570,"R5Δ","R5Δ",null,"Recessive",null,"R5",{"$nulls":37},"SVEV","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo",0,0,"Moss Vale","216","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[6283,"FB/MOF8dec","FVB.C-Myst1<tm1.1Avo>",null,"Recessive","MYST histone acetyltransferase 1","Myst1","Nil","2010203C02Rik, 5830450F21Rik, D7Ertd629e, KAT8, MOF","MGI:1915023","MYST histone acetyltransferase 1; targeted mutation 1.1, Anne K Voss ","Myst1<tm1.1Avo>","MGI:3810976","7",{"$nulls":28},"Complete embryonic lethality before somite formation:*Although embryos implant they cannot develop beyond the E4.5 blastocyst and die by E5.5.Abnormal trophectoderm morphology:*In culture, trophectoderm cells from E.5 embryos exhibit limited growth and spreading compared to wild-type cells.Inner cell mass apoptosis:*Apoptosis in the remnant inner cell masses is increased compared to in wild-type.Abnormal inner cell mass proliferation:*The inner cell mass fails to proliferate and does not form an inner cell mass outgrowth as do wild-type cells.Abnormal chromosome morphology:*Cells exhibit abnormal chromatin distribution that precedes caspase 3 activation.Increased mitotic index",null,"FVB x BALB/c","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1663","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4499,"This and That","ENU4AT:017 ",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-25","Cryopreserved sperm",44,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Anslem","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[85,null,"Trembles",null,"Recessive",null,null,"Unknown",{"$nulls":5},"4",{"$nulls":15},"Yes",{"$nulls":12},"Non-progressive mild-moderate ataxia evident at weaning. Some affecteds have shaggy fur. Full histology as been requested by APN. Video available. Phenotype unique to this chromosome location",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",110,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au","Building 117, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.14.08","N/A","No"]
[4087,null,"ENU8PH:139, Metabolic Obese 1",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"High percentage of body fat on a low fat diet",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm",30,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[6875,"BRINP2 Targetted, DBC2 Targetted","B6.Cg-Brinp2<tm1Pib>/PibMarpApb",null,"Recessive","bone morphogenic protein/retinoic acid inducible neural-specific 2","Brinp2",null,"6430517E21Rik, Fam5b, mKIAA1747","MGI:2443333","bone morphogenic protein/retinoic acid inducible neural-specific 2; targeted mutation 1, Phillip I Bird","Brinp2<tm1Pib>","MGI:5604614","1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-23","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Phil","Bird","Monash University","phil.bird@monash.edu",{"$nulls":3},"Susie","Berkowicz","Susie.berkowicz@monash.edu","SOBS/B/2008/30BC","NLRD-3430","No"]
[640,"Gz alpha knockout","C.B6-Gnaz<tm1Iah>/AnuApb","C.B6-Gnaz<tm1Iah>/AnuApb","Dominant","guanine nucleotide binding protein, alpha z subunit","Gnaz","Nil","Gz","MGI:95780","targeted mutation 1, I A Hendry","Gnaz<tm1Iah>","MGI:3575007","10",{"$nulls":15},"No",{"$nulls":12},"Hypertolerant to morphine, show anxiety.In previously unexposed female homozygotes reduced analgesia at low morphine doses is seen, a similar but not significant effect was seen in males.With repeated morphine doses mutants develop tolerance faster than wild type mice.Morphine treated homozygotes are able to tolerate higher morphine doses compared to wild type mice (LD50 of 800 mg/kg compared to 700 mg/kg for wild type)however no significant difference in the serum levels of morphine or its metabolites is seenreproductive systemLitters from homozygous parents on the C57BL/6 background had increased mortality that was not seen in litters from heterozygous or mixed strain parentstouch/vibrissae.","Decreased sensitivity to xenobiotic induced morbidity/mortality: morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 750 mg/kg compared to 700 mg/kg for wild-type).Abnormal chemically-elicited antinociception: with repeated morphine doses heterozygotes develop tolerance faster than wild-type mice but not as quickly as homozygous mutants.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","20",null,null,"No","2007-04-25","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Ian","Hendry","The Australian National University","ian.hendry@anu.edu.au","NB: Ian has retired",null,null,"Ian","Hendry","ian.hendry@anu.edu.au","N/A","N/A","No"]
[5176,"APN 33 ; VG10452","C57BL/6N-Smcr7<tm1(KOMP)Vlcg>",null,"Recessive","Smith-Magenis syndrome chromosome region, candidate region","Smcr7",null,null,"2144199","Smith-Magenis syndrome chromosome region, candidate 7 homolog (human); targeted mutation 1, Velocigene","Smcr7<tm1(KOMP)Vlcg>","MGI:3808263","11",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6N","No","Unknown","Unknown","No","Unknown","Unknown","No","Good",{"$nulls":3},"No","2010-07-14","Cryopreserved sperm",49,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu","Monash University, School of Biomedical Sciences, Level 3, Building 77, Room 306","Melbourne","VIC","Sue","Chapman","sue.chapman@monash.edu","MMCA SOP 2007/02","PC1-N09/07","No"]
[2367,"Mr Hankey ; ENU8CAT:005","B6;CB-Prkdc<hanky>/AnuApb","B6;CB-Prkdc<hanky>/AnuApb","Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","hankey","Prkdc<hanky>","MGI:4820716","16","ENSMUSG00000022672","ENSMUST00000023352","Prkdc-201","1634","1657","T to A","ENSMUSE00000282431","16","545","Leucine to STOP",{"$nulls":4},"AGGCTGTGACCAGATGGAGGATTTTATTTTAGGAGATGAAACATTTCTCTTTGTGAACTCC","Yes",{"$nulls":12},"Diarrhoea.Lymphopenia",null,"C57BL/6JAnu x CBA/CaJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",51,0,"ANU",null,"false",null,"Ian","van Driel","bio21 Institute","i.vandriel@unimelb.edu.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","N/A","N/A","No"]
[37,"Dwarf","C57BL/6JSfdAnu-Wars<tukku>/Apb",null,"Recessive","tryptophanyl-tRNA synthetase","Wars","Unknown","dwarf","MGI:104630","tukkuburko","Wars<tukku>","MGI:4819385","12","ENSMUSG00000021266","ENSMUST00000078788","Wars-201","89","220","T to C","ENSMUSE00000116158","2","30","Leucine to Proline",{"$nulls":4},"AGCTACTCAAGGGGAGCTCGTGAGGTCCCTCAAAGCTGGAAATGCACCAAAAGATGAGATT","Yes",{"$nulls":12},"Dwarfism; small at weaning/adult 60% of wt sib.Small to non-existant pituitary gland.Low IGF levels in serum.Phenotype unique to this chromosome location",null,null,"Yes","Unknown","Yes","Yes","Unknown","Yes","Yes","Good",null,"6","het x het","No","2006-02-06","Cryopreserved sperm",126,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[1490,"CD40 -/-","B6.129-CD40<tm1Klk>",null,"Recessive","CD40 antigen","Cd40","Nil","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","CD40 antigen; targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":15},"Yes",{"$nulls":12},"Unknown.Phenotype on B6 background described but not for BALB/c background.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-03",null,0,0,null,"WEHI #137","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[6344,"Mcl-1(33)/v-abl40","vavMcl-1(33)/B6.E� SV-v-abl 40 COPY",{"$nulls":3},"  Mcl1     E�vabl   ",{"$nulls":35},"vabl40 - Low incidences of plasmacytoma. Look out for dragging hind legs, enlarged spleen, enlarged menteric lymph nodes - tumours. Visually check.   1-2% will die at 20 weeks of age, 19-20% will die at 1 year. Mice die as a result of plasmcytoma. Mice will bear one of the following tumours: lymphoma, splenomegaly, messentary associated, abdominal, caecal, Peyer's Patches. They may also suffer from small bowel obstruction, intestinal haemorrhage, hind leg paralysis, intussusception,  Mcl-1 - Transgenics may have late onset haematopoietic tumours.  Expect onset of tumours from 2 months of age. Will mainly occur in mesenteric lymph node. Abdomen will look/feel enlarged.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2706","true",null,"Cassandra","Vandenberg",{"$nulls":8},"N/A","N/A","No"]
[6298,"Mcl-1flox/KO50/lckcre","C57BL/6-Mcl1<tm3Sjk> Trp53<tm1Tyj> Tg(Lck-cre)548Jxm",null,"Semi-dominant","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3",{"$nulls":16},"transgene insertion 548, Jamey Marth","mouse lck promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3109","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6298,"Mcl-1flox/KO50/lckcre","C57BL/6-Mcl1<tm3Sjk> Trp53<tm1Tyj> Tg(Lck-cre)548Jxm",null,"Semi-dominant","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11",{"$nulls":61},"N/A","N/A"]
[2464,null,"B6.CBA-Tg(hGMCSF-2CK1)79/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GM-CSF","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-16","Cryopreserved sperm",40,0,"ANU","187","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Frances","Shannon","frances.shannon@anu.edu.au","N/A","N/A","No"]
[5017,null,"BALB/c-SM22/CNX 40 tg1 (N4)",null,"Dominant",{"$nulls":39},"3","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",45,0,null,"xxx","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1511,null,"C57BL/6-Tcra<tm1Mom> Tg(TcrLCMV)327Sdz/AnuApb",null,"Recessive","T-cell receptor alpha chain","Tcra","Unknown","Tcr alpha, Tcralpha","MGI:98553","targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":15},"Yes","transgene insertion 327, Birgit Ledermann",null,"High",{"$nulls":9},"T cell express T cell receptor specific for LCMV P14 protein.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-04","Cryopreserved sperm",150,0,"ANU","030","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[46,"Kenobi ; ENU5strain:045; ENU5WT:054 ","C57BL/6JSfdAnu-Cd79a<m1Anu>/AnuApb","C57BL/6JSfdAnu-Cd79a<m1Anu>/AnuApb","Recessive","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Nil","Cd79a, Ig alpha, Ig-alpha, Iga, Ly54, mb-1","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); mutation 1, The Australian National University","Cd79a<m1Anu>","MGI:5006856","7","ENSMUSG00000003379","ENSMUST00000003469","Cd79a-001","186","327","G to A","ENSMUSE00000199568","2","62","Tryptophan to STOP",{"$nulls":4},"AATGGCAGGAACCCTAATATCACATGGTGGTTCAGCCTTCAGTCTAACATCACATGGCCCC","Yes",{"$nulls":12},"Immune deficiency. Hypogammaglobulinemia. Absolutely no B cells or pre-B cells.",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unknown",{"$nulls":3},"No","2004-04-28","Cryopreserved sperm",66,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[5002,"aFO8 aa262","FVB/N-Tg(Prm1-Pebp1)8Mkob/MarpApb",null,"Dominant",{"$nulls":25},"phosphatidylethanolamine binding protein 1","Protamine 1","low level expression",{"$nulls":11},"FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","0",null,null,"No","2010-02-22","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Gerard","Gibbs","ggibbs@unimelb.edu.au","N/A","N/A","No"]
[5180,null,"ENU15CHINA:075b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"CD4:CD8 T cell ratio skew. Decreased CD4 population and increased CD8 population","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-07-19","Cryopreserved sperm",10,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":3},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","J.APF.19.08","N/A","No"]
[4178,"APN4","B6;129-Rbbp4<Gt(AD0773)Wtsi>/MIMR",null,"Recessive","retinoblastoma binding protein 4","Rbbp4","Unknown","CAF-1 p48 subunit, mRbAp48","MGI:1194912","retinoblastoma binding protein 4; gene trap AD0773, Wellcome Trust Sanger Institute","Rbbp4<Gt(AD0773)Wtsi>","MGI:3863854","4",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","1",null,"Chimera x C57BL/6","No","2008-12-18","Cryopreserved sperm",45,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","deborah.bianco@monash.edu","N/A","N/A","No"]
[4574,"FATT-129Sv/EvTac","129Sv-Lepr<FATT>/Apb",null,"Semi-dominant","Leptin Receptor","LepR","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, OB-RGRP, obese-like, obl, Obr","MGI:104993","FATT",null,null,"4",{"$nulls":15},"No",{"$nulls":12},"The homozygote mutant has juvenile obesity, florid diabetes. The adult is hypogonadal and does not breed, and had an increased body length (10-20%).","There is a slight change in adipose tissue distribution and liver weight but no other significant changes.","129Sv/EvTac","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-03-08","Cryopreserved sperm",144,0,null,null,"false",null,"Brian","Oldfield","Monash University","brian.oldfield@med.monash.edu.au",{"$nulls":3},"Brian","Oldfield","brian.oldfield@med.monash.edu.au","N/A","N/A","No"]
[5718,"Dallaglio KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5719,"Dan Blackmore C57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4730,null,"NOD.B6.Cg-H2<k> Tg(TLK2mHEL)2Ccg/AnuApb","NODB6.Cg-H2<k> Tg(TLK2mHEL)2Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid",{"$nulls":9},"Express low levels of membrane bound HEL in thyroid. Low serum levels of HEL detected.",null,"NOD.Cg-H2<k> x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2009-04-17","Cryopreserved sperm",95,0,"ANU","212","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[5010,"Zedd","FVB/n-Luciferase Tg1 (ASD069)",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",150,0,null,"ABS #069","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6947,"ENU19 WT:023:a:B6:G3","ANU:ENU19WT:023:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",59,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4434,null,"ENU7B6:011",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,"C57BL/6 x C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"3",null,"No","2009-02-17","Cryopreserved sperm",30,0,null,null,"false",null,"Katrina","Randall","The Australian National University","katrina.randall@anu.edu.au",{"$nulls":3},"Katrina","Randall","katrina.randall@anu.edu.au","N/A","N/A","No"]
[4577,null,"NOD.129S7-H2<k> Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Nil","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k2 variant","H2<k2>","MGI:4936842","17","Abnormal immune system",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm",120,0,"ANU",null,"false",null,"David","Willenborg","The Australian National University","david.willenborg@anu.edu.au",{"$nulls":3},"Ms","Fordham",null,"N/A","N/A","No"]
[4578,null,"PLJ.129S7-Ifngr1<tm1Agt>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal immune system",null,"PLJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-03-08","Cryopreserved sperm",60,0,"ANU",null,"false",null,"David","Willenborg","The Australian National University","david.willenborg@anu.edu.au",{"$nulls":3},"Ms","Fordham",null,"N/A","N/A","No"]
[5251,"FHWMKA","B6.129-Fxn<tm1Mkn> Tg(FXN)CSars/Apb",null,"Recessive","Frataxin","Fxn",null,"Frda","MGI:1096879","frataxin; targeted mutation 1, Michel Koenig","Fxn<tm1Mkn>","MGI:2177162","19",{"$nulls":15},"No","Human FRATAXIN gene","FXN endogenous promoter",{"$nulls":10},"Homozygous FXN transgene: Normal.Homozygous Fxn knockout: embryonic lethal, but completely complemented by presence of FXN transgene.","Hemizygous FXN transgene: Normal.Heterozygous Fxn knockout: Normal.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16","Hemizygous FXN transgene and Homozygous Fxn knockout  X Hemizygous FXN transgene and Homozygous Fxn knockout","Yes","2010-10-20","Cryopreserved sperm",45,0,null,null,"false",null,"Joseph","Sarsero","Murdoch Childrens Research Institute","joe@sarsero.com","Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children","Parkville","Victoria","Joseph","Sarsero","joe@sarsero.com","A660","2261/2006","No"]
[5519,"17China 43b","C57BL/6JAnu-Ptprc<m1Anu>/Apb",null,"Dominant","protein tyrosine phosphatase, receptor type, C","Ptprc ","Reduced","B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","mutation 1, The Australian National University","Prtprc<m1Anu>",null,"1",{"$nulls":15},"No",{"$nulls":12},"Blood lymphopenia","Reduced expression of CD45","C57BL/JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"3","Sib x sib","No","2011-06-07","Cryopreserved sperm",50,0,null,null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[5373,"NOD.SCID/BDC2.5","NOD.Cg-Prkdc<scid> Tg(TcraBDC2.5,TcrbBDC2.5)1Doi",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":16},"transgene insertion 1, Christophe Benoist",{"$nulls":12},"InsulitisIncreased activated T cell number","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #79","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4775,"5AT142","ENU5AT:142",null,"Recessive",{"$nulls":25},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter",{"$nulls":10},"Heightened susceptibility to autoimmune diabetes on the transgenically sensitized TCR x insHEL background (see figure). Phenotype Screen: Urine glucose","Normal","C57BL/6 x B10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",50,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Stephen","Daley","stephen.daley@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5374,"Hom.NOD.FADD51","NOD/Lt-Tg(Ins2-dnFADD)51Wehi",null,"Dominant",{"$nulls":25},"dominant negative Fas associated death domain protein","rat insulin promoter (Ins2) (RIP)","2 - 3 copies",{"$nulls":9},"Islets developed normally in these animals.β cells from the transgenic mice were resistant to killing via the Fas pathway in vitro.A reduced incidence of diabetes was found in mice with higher levels of dominant-negative FADD expression.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #80","true",null,"Janette","Allison","St Vincent's Institute","janettea@unimelb.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4918,"CD9 -/-","B6.129-CD9<Bcx>/AusbApb",null,"Recessive","CD9 antigen","Cd9","Nil","Tspan29","MGI:88348","targeted mutation 1, Claude Boucheix","Cd9<tm1Bcx>","MGI:2180795","6",{"$nulls":28},"Reduced female fertility: 40 - 50% of females fail to produce litters.Decreased litter size.Impaired fertilization: impaired sperm - egg fusion.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2009-10-20","Cryopreserved sperm",90,0,"ABR - Moss Vale",null,"false",null,"Leonie","Ashman","The University of Newcastle","Leonie.Ashman@newcastle.edu.au",{"$nulls":3},"Leonie","Ashman","Leonie.Ashman@newcastle.edu.au","N/A","N/A","No"]
[6948,"ENU19 WT:025:b:B6:G3","ANU:ENU19WT:025:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4606,"mIMPα4delta","C57BL/6-Tg(EGFP-Kpna4 dominant negative) ",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"3",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","EGFP fused to dominant negative Kpna4","Protamine 1",{"$nulls":10},"Fertility maybe reduced.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm",20,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[5020,"N4.WB6.Hep.516Kl/+","N4.WB6.Hep.516Kl/+",null,"Dominant",{"$nulls":39},"8","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",120,0,null,"xxx","true",null,"Mark","Hulett","The Australian National University","mark.hulett@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4603,"mIMPα2FL","C57BL/6-Tg(EGFP-Kpna2 full length) ",null,"Recessive","karyopherin (importin) alpha 2","Kpna2","Unknown","Importin alpha, m-importin, m-importin-alpha-P1, pendulin, Rch1","MGI:103561",{"$nulls":3},"11",{"$nulls":15},"Yes","EGFP fused to full length Kpna2","Protamine 1",{"$nulls":10},"Unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm",40,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[3472,"CD11c-mOVA","C57BL/6-Tg(Itgax-mOVA)",null,"Dominant",{"$nulls":25},"membrane bound ovalbumin","CD11c (mouse) (Itgax)",{"$nulls":10},"Normal. Transgenic mice express membrane bound ovalbumin under the control of the CD11c promoter.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #486","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5492,"Ndfip - 2 (SV129 Background)","Ndfip - 2 (SV129 Background)",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Unknown",null,"129Sv","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-05-02","Cryopreserved sperm",40,0,null,null,"true",null,"Sharad","Kumar","Hanson Institute","sharad.kumar@health.sa.gov.au",{"$nulls":3},"Kathryn","Mills","kathryn.mills@health.sa.gov.au","N/A","N/A","No"]
[6810,"L12SLR1R","SJL.B6-L12SLR1R<C57BL/6>/MriApb",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"9","This allele confers normo-susceptibility to Plasmodium chabaudi compared to wildtype SJL.",null,"SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"Yes","2012-02-01","Cryopreserved sperm",70,0,null,null,"false",null,"Gaetan","Burgio","Menzies Research Institute","grburgio@utas.edu.au",{"$nulls":3},"Gaetan","Burgio","grburgio@utas.edu.au","A0101469",null,"No"]
[6950,"ENU19 WT:029:a:B6:G3","ANU:ENU19WT:029:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4520,null,"ENU8C:051",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm",150,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[2780,"C57BL/6.Flii 2.1A","B6.C-Flii<tm1Hdc>/3AnuApb","B6.C-Flii<tm1Hdc>/3AnuApb","Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal","No obvious altered phenotype","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10","11","Het male x WT female","No","2008-02-16","Cryopreserved sperm",105,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[5177,"17FOX 014 B6.129-Tg(FoxP3-GFP)","ENU17FOX:014 Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Reduced B cell population, visualised via flow cytometric analysisCells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Affected x affected","No","2010-07-19","Cryopreserved sperm",20,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":3},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","J.APF.19.08","N/A","No"]
[5177,"17FOX 014 B6.129-Tg(FoxP3-GFP)","ENU17FOX:014 Foxp3<tm2Ayr>",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown",{"$nulls":42},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","J.APF.19.08","N/A"]
[5784,"FGF9",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5788,"Floxed ErbB4 ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4827,"6AT:022","ENU6AT:022",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5117,"TH-GFP","C57BL/6-Tg(Th-EGFP)21-31Koba",null,"Dominant",{"$nulls":25},"transgene insertion 21-31, Kazuto Kobayashi","rat tyrosine hydroxylase gene","High, 10 copies",{"$nulls":9},"Strong GFP fluorescent signal is detected in typical catecholaminergic cell groups and in most dopaminergic neurons of the transgenic adult ventral midbrain. Embryonic expression begins in the dopaminergic neurons of the developing ventral midbrain around E11-E12, is dramatically reduced later in gestation, and gradually resumes postnatally.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-12",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[4714,"Rolex/129","129-Hccs<tm1Tcc>/MarpApb",null,"X-linked","holocytochrome c synthetase","Hccs","Unknown",null,"MGI:106911","targeted mutation 1, Timothy C Cox","Hccs<tm1Tcc>","MGI:3826866","X",{"$nulls":15},"Yes",{"$nulls":12},"NormalHomozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm",150,0,"Monash",null,"false",null,"Timothy","Cox","Monash University","timothy.cox@med.monash.edu.au",{"$nulls":3},"Timothy","Cox","timothy.cox@med.monash.edu.au","N/A","N/A","No"]
[4646,null,"MRL/MpJ-Icam<tmBay> Fas<lpr>/JMarpApb",null,"Recessive","intercellular adhesion molecule 1","Icam1","Nil","CD54, Icam-1, Ly-47, MALA-2, MGC:6195","MGI:96392","targeted mutation 1, Baylor College of Medicine","Icam1<tm1Bay>","MGI:1857183","9",{"$nulls":15},"Yes",{"$nulls":12},"MRL/MpJ-Fas(lpr) (Fas(lpr)) mice develop a rapidly fatal form of systemic autoimmune disease characterized by glomerulonephritis and vasculitis similar to severe cases of systemic lupus erythematosus in humans. ICAM-1 deficiency resulted in a striking improvement in the survival of Fas(lpr) mice (median +/- SEM survival of Fas(lpr) = 26 +/- 1.7 vs ICAM-1/Fas(lpr) = 47 +/- 2.4 wk, p < 0.0001) and the increased survival was associated with delayed elevations of blood urea nitrogen levels in the ICAM-1/Fas(lpr) mice. Histologic examination of the ICAM-1/Fas(lpr) mice revealed an overall reduction in glomerular disease and a significant reduction in vasculitis in the kidney, lung, skin, and salivary glands when compared with Fas(lpr).",null,"MRL/MpJ","Yes","No","Yes","Yes","No","Yes","No","Unknown","10",null,null,"No","2009-03-22","Cryopreserved sperm",105,0,"Monash",null,"true",null,"Michael","Hickey","Monash University","michael.hickey@med.monash.edu.au",{"$nulls":3},"Michael","Hickey","michael.hickey@med.monash.edu.au","N/A","N/A","No"]
[4646,null,"MRL/MpJ-Icam<tmBay> Fas<lpr>/JMarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","Unknown",{"$nulls":58},"Michael","Hickey","michael.hickey@med.monash.edu.au","N/A","N/A"]
[4698,null,"NOD.Cg-Tg(H2-Ea-Atp4b)1Wehi/WehiApb",null,"Dominant",{"$nulls":25},"ATPase, H+/K+ exchanging, beta polypeptide (Atp4b)","1.8-kb fragment encoding nucleotides -1,903 through -39 of the 5' flanking sequence of the MHC Class II gene, H2-Ea (k allele)",{"$nulls":12},"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",155,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[337,"C57BL/6J-Rag1<tm1>TgN(OT-I)","B6.129-Rag1<tm1Bal> Tg(TcraTcrb)1100Mjb",null,"Recessive","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, David Baltimore","Rag1<tm1Bal>","MGI:2448994","2",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",{"$nulls":13},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-05",null,0,0,null,null,"true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6809,null,"SJL/Mrit-MRI47495",null,"Dominant","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Macrocytic anaemia","Macrocytic anaemia","SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-02-01","Cryopreserved sperm",70,0,null,null,"false",null,"Gaetan","Burgio","Menzies Research Institute","grburgio@utas.edu.au",{"$nulls":3},"Gaetan","Burgio","grburgio@utas.edu.au","A0101470",null,"No"]
[5118,"Ednrb-Kik","Un-Tg(Ednrb-Kik)",null,"Dominant",{"$nulls":25},"Kikume","Endothelin receptor B","Unknown",{"$nulls":9},"Ednrb-expressing cells in the gut express the photoconvertible protein, Kikume.",null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-05-12",null,0,0,null,null,"true",null,"Heather","Young","The University of Melbourne","h.young@unimelb.edu.au",{"$nulls":3},"Heather","Young","h.young@unimelb.edu.au","N/A","N/A","No"]
[7063,"Momme D25","FVB/NJ-MommeD25 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D25","MommeD25","Unknown",{"$nulls":5},"3",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD25<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24","Cryopreserved sperm",39,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor","Tnf","Normal","DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha","MGI:104798","targeted mutation 2, Jonathon D Sedgwick","Tnf<tm2Jods>","MGI:3578747","17",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-20","Cryopreserved sperm",100,301,null,"ABS #017","true",null,"Geeta","Chaudhri","The Australian National University","geeta.chaudhri@anu.edu.au",{"$nulls":3},"Geeta","Chaudri","geeta.chaudhri@anu.edu.au","N/A","N/A","No"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1a","Tnfrsf1a","Nil","CD120a, p55, p55-R, TNF receptor alpha chain, TNF-alpha-R1, TNF-alphaR1, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRI, TNFRp55","MGI:1314884","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1a<tm1Imx>","MGI:1857468","6",{"$nulls":58},"Geeta","Chaudri","geeta.chaudhri@anu.edu.au","N/A","N/A"]
[2395,null,"C57BL/6-Tnf<tm2Jods> Tnfrsf1a<tm1IMx> Tnfrsf1b<tm1Imx>",null,"Recessive","tumor necrosis factor receptor superfamily, member 1b","Tnfrsf1b","Nil","CD120b, p75, p75 TNFR, TNF-alphaR2, TNF-R-II, TNF-R2, TNF-R75, TNFalpha-R2, TNFBR, Tnfr-1, Tnfr2, TNFR80, TNFRII","MGI:1314883","targeted mutation 1, Immunex Research and Development Corporation","Tnfrsf1b<tm1Imx>","MGI:1860087","4",{"$nulls":58},"Geeta","Chaudri","geeta.chaudhri@anu.edu.au","N/A","N/A"]
[867,"B6.Fas-/-","B6;129P2-Fas<tm1Osa>/Apb","B6;129P2-Fas<tm1Osa>/Apb","Recessive","Fas (TNF receptor superfamily member)","Fas","Nil","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","targeted mutation 1, Osaka University Medical School","Fas<tm1Osa>","MGI:1861923","19",{"$nulls":15},"No",{"$nulls":12},"Premature death: 50% dead at about 5 months of ageAbnormal hepatocyte morphology: hepatocyte nuclear areas are variable and larger.Liver hyperplasia: * significantly heavier at 12 weeks of age and becomes 50-60% heavier by 16 weeks of age.* number of hepatocytes per each liver lobe is increasedimmune system.Increased leukocyte cell number: 20x higher than in controls, attributable to increased lymphocyte numbers.Increased lymphocyte cell number:* lymphocytosis; progressively accumulate abnromal T cells Thy1<+> B220<+> CD4<-> CD8<->.Increased B cell number: increase in the number of normal B cells.Abnormal T cell clonal deletion:* peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired.Abnormal lymph organ size.Enlarged spleen: spleen becomes progressively larger.Enlarged lymph nodes: lymph nodes become progressively larger.Lymphoid hyperplasia.Increased IgG level: 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age.Increased IgG1 level.Increased IgG2a level.Increased IgG2b level.Increased IgG3 level.Increased autoantibody level:* 50-500x higher levels of dsDNA and ssDNA autoantibodies at 16 weeks of age.Increased anti-double stranded DNA antibody level.Increased anti-single stranded DNA antibody level.Increased susceptibility to parasitic infection:* decreased survival after infection with Trypanosoma cruzi even though were able to clear parasites from blood and affected organs.Hypersensitivity:* occasional infiltration of lymphocytes into tissues such as the lungs and liver.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-25","Cryopreserved sperm",139,0,"ANU","124","false",null,"Arno","Mullbacher","The Australian National University","arno.mullbacher@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4776,"TOMtg","FVB-Tg(tetO-MYC)1Lach/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Lewis A Chodosh","bacterial tetracycline-resistance operon",{"$nulls":10},"Normal",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",95,0,null,null,"false",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Chris","Ormandy","c.ormandy@garvan.org.au","J.APF.12.08","N/A","No"]
[5181,"Mif -/- Fas<lpr>","MRL/MpJ.Cg-Fas<lpr> Mif<tm1Dvd>/MarpApb",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":15},"Yes",{"$nulls":12},"MIF<–/–>MRL/lpr mice had significantly less proteinuria than MIF<+/+>MRL/lpr mice.Ab production in the MRL<lpr> mice was largely unaffected by MIF deficiency.No difference in the percentage of CD4<+> or CD8<+> T cells, B cells (CD3<->B220<+>), CD3<+>CD4<->CD8<->B220<+> double-negative T cells (DNTCs), or CD11b<+>CD11c<+> dendritic cells between MIF<+/+> and MIF<–/–>MRL<lpr> mice.MIF<–/–>MRL<lpr> mice were protected from crescentic glomeruli formation as compared to MRL<lpr> mice.MIF deficiency reduces renal macrophage recruitment and MCP-1 expression.",null,"MRL/MpJ","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-07-19","Cryopreserved sperm",70,0,"Monash",null,"false",null,"Michael","Hickey","Monash University","Michael.Hickey@med.monash.edu.au",{"$nulls":3},"Pam","Hall","Pam.Hall@monash.edu","N/A","N/A","No"]
[5181,"Mif -/- Fas<lpr>","MRL/MpJ.Cg-Fas<lpr> Mif<tm1Dvd>/MarpApb",null,"Recessive","macrophage migration inhibitory factor","Mif","Nil","Glif","MGI:96982","macrophage migration inhibitory factor; targeted mutation 1, John R David","Mif<tm1Dvd>","MGI:2176337","10",{"$nulls":15},"No",{"$nulls":42},"Pam","Hall","Pam.Hall@monash.edu","N/A","N/A"]
[6949,"ENU19 WT:026:a:B6:G3","ANU:ENU19WT:026:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",20,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[657,"transgenic line MBP-c-myc ","B6.129-Tg(Mbp-MYC*)/Apb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","exons 2 and 3 of the human c-myc gene","1.3Kb of the mouse myelin basic protein (Mbp)","very low",{"$nulls":9},"Mice exhibit a transient shivering phenotype over the period corresponding to the peak of central nervous system myelination (4 to 8 weeks postnatally). Thereafter, shivering decreases abruptly and mice go on to live a normal life-span and breed normally.","As for heterozygous, but more pronounced. Death between 4 and 8 weeks has been observed but is rare. ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent","38",null,"transgenic males mated to normal C57BL/6 females between about 7 to 15 weeks of age","No","2007-04-26","Cryopreserved sperm",110,0,null,null,"false",null,"Jacqueline","Orian","La Trobe University","J.Orian@latrobe.edu.au",{"$nulls":3},"Jacqueline","Orian","J.Orian@latrobe.edu.au","N/A","N/A","No"]
[4846,"Pricilla","ENU6CAT:04",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",160,0,null,null,"true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[5113,"Joey-SCO","C57BL/6JAnu-Etv5<sco>/AnuMarpApb","C57BL/6JAnu-Etv5<sco>/AnuMarpApb","Recessive","ets variant gene 5","Etv5","Unknown","ERM","MGI:1096867","ets variant gene 5; sco","Etv5<sco>","MGI:5563470","16","ENSMUSG00000013089","ENSMUST00000079601","Etv5-202","1234","1414","A to T","ENSMUSE00000560895","12","412","Lysine to STOP",{"$nulls":4},"AAGAGGTTGCTCGCCGTTGGGGTATCCAGAAGAATCGGCCAGCCATGAACTATGACAAGCT","No",{"$nulls":12},"Sertoli cells only.Male infertility.Progressive loss of germ cells following the first wave of spermatogenesis.Germ cells appeared to be preferentially lost in a basal to apical direction from the seminiferous epithelium as detected in 7 week old testis.Reduced testis size, compared to WT, at 8 weeks of age.Etv5 mRNA levels 95% reduced compared to WT males.Etv5 mRNA is unstable.Reduced expression of Etv5 target genes Cxcr4 and Ccl9.Increased incidence of embryonic and perinatal lethality.Reduced body weight.Renal asymmetry.Polydactyly.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2010-05-10","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@med.monash.edu.au",{"$nulls":3},"Moira","O'Bryan","Moira.O'Bryan@med.monash.edu.au","N/A","N/A","No"]
[4712,"T3RWT","B6.129-Tlr3<WT>",null,"Dominant","toll-like receptor 3","Tlr3","Unknown",null,"MGI:2156367",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Wild-type strain used as control for Tlr3 knockout, APB ID#630",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm",100,0,null,null,"false",null,"Bryan","Williams","Monash University","bryan.williams@med.monash.edu.au",{"$nulls":3},"Aneta","Dowsing","Aneta.dowsing@med.monash.edu.au","N/A","N/A","No"]
[5778,"FGF8Flox/Rosa26/NesCreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3383,"K14-Grhl3","B6-Tg(K14-Grhl3) ",null,"Dominant",{"$nulls":25},"grainyhead-like 3 (Drosophila) (Grhl3)","keratin 14 (K14)",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"transgenic x transgenic","No","2008-07-09","Cryopreserved sperm",150,0,null,null,"true",null,"Tomasz","Wilanowski","Walter and Eliza Hall Institute of Medical Research","wilanowski@wehi.edu.au",{"$nulls":3},"Tomasz","Wilanowski","wilanowski@wehi.edu.au","N/A","N/A","No"]
[4475,null,"Brooke",null,"Dominant",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm",50,0,null,"ABS #179","true",null,"Paul","Foster","The University of Newcastle","paul.foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair Reid@anu.edu.au","N/A","N/A","No"]
[4845,null,"ENU6AT:53",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Mothers fail to lactate.Pups can be maintained by adding lactating foster mother.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",40,0,null,null,"true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[4721,"TGM2 floxed","C57BL/6-Tgm2<tm1Rmgr>/Apb",null,"Recessive","transglutaminase 2, C polypeptide","Tgm2","Normal","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 1, Robert M Graham","Tgm2<tm1Rmgr>","MGI:3525256","2",{"$nulls":15},"Yes",{"$nulls":12},"Normal - no phenotypic analysis * mice were only used to generate the null allele",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm",59,0,"Victor Chang",null,"false",null,"Robert","Graham","Victor Chang Cardiac Research Institute","b.graham@victorchang.edu.au",{"$nulls":3},"Robert","Graham","b.graham@victorchang.edu.au","N/A","N/A","No"]
[5723,"DCCKanga",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5724,"Dcckanga/Tomato/Satb2Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5456,"ENU14Ch 036b; ENU14China:036b","C57BL/6JAnu-Cd22<m1Anu>/AnuApb","C57BL/6JAnu-Cd22<m1Anu>/AnuApb","Recessive","CD22 antigen","Cd22","Reduced","Lyb-8, Lyb8","MGI:88322","CD22 antigen; mutation 1, Australian National University","Cd22<m1Anu>","MGI:5009050","7","ENSMUSG00000030577","ENSMUST00000019248","Cd22-201","1536","2116","T to A","ENSMUSE00000359124","7","511","Cysteine to STOP",{"$nulls":4},"GTCAGCTGTGCTGCCTGCAACCACAAGTGTTCGTGGGCCCTCCCTGTCATCCTGAATGTCC","Yes",{"$nulls":12},"Block in B cell maturation and reduced number of B cells in peripheral blood.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm",47,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[108,"Alison2 ; AL3","C57BL/6JSfdAnu-Tg(AlsHEL)3Ccg/AnuApb","C57BL/6JSfdAnu-Tg(AlsHEL)3Ccg/AnuApb","Dominant",{"$nulls":25},"soluble Hen Egg Lysozyme (HEL)","liver specific albumin","high",{"$nulls":9},"High ubiquitous expression of soluble Hen Egg Lysozyme (sHEL). Females express approximately 2-fold more sHEL than males of this strain.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","Hom xHom","No","2006-02-06","Cryopreserved sperm",125,0,"ANU","209","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[4731,"Rama","C57BL/6-Tg(H2-K-sHELdimer)/Apb",null,"Dominant",{"$nulls":25},"soluble Hen Egg Lysozyme dimeric molecule","H-2K<b>","Low",{"$nulls":9},"Low serum expression of dimeric soluble HEL.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-17",null,0,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[4803,"Mal ; ENU8BAT:012","B6(Cg);CBA-Rabl2a<mot>/AnuApb",null,"Recessive","RAB, member of RAS oncogene family-like 2A","Rabl2a",null,null,"MGI:1915958","RAB, member of RAS oncogene family-like 2; mot","Rabl2<mot>","MGI:5469381","15","ENSMUSG00000022621","ENSMUST00000023294","Rabl2a-201","218","311","A to G","ENSMUSE00000128937","5","73","Aspartic acid to Glycine",{"$nulls":4},"CACAGTAGACGGCAAGACGATCCTTGTGGACTTCTGGGATACAGCAGGCCAGGAGCGGTTC","Yes",{"$nulls":12},"Male InfertilityDecreased testis weightOligozoospermiaShort sperm flagellumAsthenozoospermia:• low total motility and minimal progressive motility• however, ultrastructure is normal",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",115,0,"ANU",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Moira","O'Bryan","Moira.O'Bryan@monash.edu","J.APF.09.07","N/A","No"]
[2767,"BALB/c.Flii<-/-> FLII<c110H8/c110H8> ; FICR","BALB/c-Flii<tm1Hdc> Tg(FLII)1Hdc/AnuApb","BALB/c-Flii<tm1Hdc> Tg(FLII)1Hdc","Recessive","flightless I homolog (Drosophila)","Flii","Unknown","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"Yes","transgene insertion 1, Hugh D Campbell","human flightless promoter",{"$nulls":10},"Embryonic lethal phenotype of FLii knockout is rescued by human FLII transgene. Ubiquitous expression of human Flightless gene.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"FLii<-/-> FLII<c110H8/c110H8> x FLii<-/-> FLII<c110H8/c110H8>","No","2008-02-15","Cryopreserved sperm",120,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[5725,"DccKangC57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4705,"NOD-HIPCre","NOD-Tg(INS-cre)2Rms/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Robyn M Slattery","human insulin promoter","beta islet cells",{"$nulls":9},"The human insulin promoter (INS) drives cre expression in beta islet cells. Resistance to development of diabetes and hyperglycemia",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",135,0,"Monash",null,"false",null,"Robyn","Slattery","Monash University","Robyn.Slattery@med.monash.edu.au",{"$nulls":3},"Robyn","Slattery","Robyn.Slattery@med.monash.edu.au","N/A","N/A","No"]
[5184,"Vincent ; KRN 14 Vincent B6 F2","KRN:014 Vincent B6 F2",null,"Recessive","glutamate receptor, ionotropic, kainate 4","Grik4","Unknown","6330551K01Rik, GluRgamma1, KA-1, KA1 ","MGI:95817",{"$nulls":3},"9",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-07-26","Cryopreserved sperm",45,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.20.08","N/A","No"]
[7703,"ENU29:G3","ANU:ENU29:G3",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","1",null,null,"No","2014-06-17","Cryopreserved sperm",138,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[5631,"B6.129x1BAX",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7514,"QSi5","Quackenbush Swiss i5",null,"Dominant",{"$nulls":37},"Outbred strain derived from Quackenbusg Swiss.Highly fecund - average litter size 13.4Large litter size.Shorter period between litters.Septum primum or flap valve length (FVL) - long compared to 129 - 1.13mm v 0.6mmMilk yield 3x greater than CBA.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-28","Embryo",0,0,null,null,"true",null,"Ian","Martin","The University of Sydney","ian.martin@sydney.edu.au",{"$nulls":6},"N/A",null,"No"]
[109,"Andrew2 ; ML4","C57BL/6JSfdAnu-Tg(ML4sHEL)4Ccg/AnuApb","C57BL/6JSfdAnu-Tg(ML4sHEL)4Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow ; soluble HEL (hen egg lysozyme)","zinc inducible mouse metallothionein I","High",{"$nulls":9},"Mice homozygous for the TgN(ML5sHEL)5Ccg transgene express a soluble form of hen egg lysozyme.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"10","sib x sib","No","2006-02-06","Cryopreserved sperm",140,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[4737,null,"ENU8C:060",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","1",null,null,"No","2009-04-19","Cryopreserved sperm",70,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","lina.tze@anu.edu.au","N/A","N/A","No"]
[7515,"QSi5","Quackenbush Swiss i5",null,"Dominant",{"$nulls":37},"Highly fecund - large litter sizeShorter time between littersImproved lactation - compared to CBA. Higher milk yield, more efficient milk production.Septum primum or flap valve length (FVL) longer compared to 129T2 - 1.11 mm v 0.6mm.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-28","Embryo",0,0,"ARC",null,"true",null,"Ian","Martin","The University of Sydney","ian.martin@sydney.edu.au",{"$nulls":6},"N/A",null,"No"]
[128,"Deirdre ; IgMdE","C57BL/6JSfdAnu-Tg(IgMδEHEL)Ccg/AnuApb","C57BL/6JSfdAnu-Tg(IgMδEHEL)Ccg/AnuApb","Dominant",{"$nulls":25},"chimeric anti-Hen Egg Lysozyme Ig molecule, the extracellular spacer of IgM was substituted for IgD.",null,"H and L genes are cointegrated",{"$nulls":9},"B cells express chimeric IgM/D molecule with affinity for Hen Egg Lysozyme",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"10","sib x sib","No","2006-02-06","Cryopreserved sperm",20,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[5459,"ENU16Ch:017a, Lyn<T410A>","C57BL/6JAnu-Lyn<m1Anu>/AnuApb","C57BL/6JAnu-Lyn<m1Anu>/AnuApb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog  ","Lyn","Unknown","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; mutation 1, Australian Phenomics Facility","Lyn<m1Apb>","MGI:5501039","4","ENSMUSG00000042228","ENSMUST00000041377","Lyn-001","1228","1483","A to G","ENSMUSE00000605548","12","410","Threonine to Alanine",{"$nulls":4},"GGGAAGGTGCGAAGTTCCCTATCAAGTGGACAGCTCCAGAGGCCATCAACTTCGGCTGCTT","No",{"$nulls":12},"Very low B cells numbers but High IgM<+>IgD<-> cells.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm",45,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","APF.14.08","N/A","No"]
[6356,"KRAS2f","B6.129-Kras<tm4Tyj>/Ausb",null,"Semi-dominant","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","Kras",null,"K-ras, Ki-ras, Kras-2, Kras2 ","MGI:96680 ","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks","Kras<tm4Tyj>","MGI:2429948","6",{"$nulls":28},"Increased lung tumor incidence:*Treatment with adenoviral Cre to induce oncogenic Kras expression results in lung tumor development, but causes a lower tumor burden and decreased overall tumor area compared to induced mutants on a Spry2-null background.",null,"B6/129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","561","true",null,"Andrew","Biankin","Garvan Institute","a.biankin@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","H2A histone family, member B2","H2afb2","Nil","EG624153, H2A.Bbd4, H2afb2-ps","MGI:3644980",{"$nulls":3},"X",{"$nulls":28},"Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","FVB/NJArc","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"het to wt; homo to wt; homo to homo","No","2014-06-18","Cryopreserved sperm",48,0,null,null,"false",null,"David","Tremethick","The Australian National University","david.tremethick@anu.edu.au",{"$nulls":3},"Tatiana","Soboleva","tanya.soboleva@anu.edu.au","A2066/11",null,"Yes"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","H2A histone family, member B3","H2afb3",null,"EG624957, H2A.Bbd3, H2afb3-ps","MGI:3644875",{"$nulls":3},"X",{"$nulls":58},"Tatiana","Soboleva","tanya.soboleva@anu.edu.au","A2066/11"]
[7704,"H2A.Lap1:NM1","FVB/NJArc-H2afb2<tm1> H2afb3<tm1> Gm14920<tm1>/AnuApb",null,"X-linked","predicted pseudogene 14920","Gm14920",null,"ENSMUSG00000067441, H2A.Bbd1","MGI:3642445",{"$nulls":3},"X",{"$nulls":58},"Tatiana","Soboleva","tanya.soboleva@anu.edu.au","A2066/11"]
[5740,"DTA",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5741,"E2F7-/- (295/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7673,"Solox Low x AR 2-/-","B6;CBA-Ifnar2<tm1Pjh> Tg(sIfnar2)Pjh/MarpApb",null,"Recessive","interferon (alpha and beta) receptor 2","Ifnar2","Nil","Ifnar-2 ","MGI:1098243 ","interferon (alpha and beta) receptor 2; targeted mutation 1, Paul J Hertzog","Ifnar2<tm1Pjh>","MGI:2680693","Unknown",{"$nulls":16},"interferon (alpha and beta) soluble receptor 2 low expression ",null,"Low",{"$nulls":9},"Unknown","Unknown","C57BL/6 (tbc)","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2014-05-07","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Paul","Hertzog","Monash University","paul.hertzog@monash.edu",{"$nulls":3},"Kelly","Rodwell","kelly.rodwell@monash.edu","MMCA/2008/25 BC","PC1-N22-14","No"]
[3340,"C57BL/6 Tg(IL5)C2","B6.CBACa-Tg(CD2-Il5)5C2Ldt/Apb [cc]","B6.CBACa-Tg(CD2-Il5)5C2Ldt/Apb [cc]","Dominant",{"$nulls":25},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia. Northern blot analysis identified 11,5 mRNA in the thymus, Peyer's patches, and subcutaneous (pooled inguinal and axillary) lymph nodes. No IL5 mRNA was detected in liver, heart, brain, or skeletal muscle tissues from transgenics, nor in any tissues from normal littermates. Do not maintain as homozygotes. While this is apparently possible, survival of homozygotes likely to be lower.","C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","20",null,"Tg male wild type female","No","2008-06-20","Cryopreserved sperm",75,0,null,null,"false",null,"Lindsay","Dent","The University of Adelaide","Lindsay.Dent@adealide.edu.au",{"$nulls":3},"Lindsay","Dent","Lindsay.Dent@adealide.edu.au","N/A","N/A","No"]
[7277,"SJL.RIIa Tg","SJL.Fcgr2a Tg","HOGA","Semi-dominant","Fcgamma r2a","FcgR2a","Normal",{"$nulls":5},"Unknown",{"$nulls":16},"human FcyR2a","human FcyR2a","normal",{"$nulls":9},"spontaneous arthritis","not known","SJL","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","12",null,null,"Yes","2013-02-15","Cryopreserved sperm",45,0,null,null,"true",null,"Mark","Hogarth","Burnet","pmhogarth@burnet.edu.au",{"$nulls":3},"Eva","Orlowski","eorlowski@burnet.edu.au","B/BL-2008/195IL",null,"Yes"]
[4736,"Anasette","ENU5AT:140 ",null,"Recessive",null,null,"Unknown",null,null,"Anasette",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2009-04-19","Cryopreserved sperm",120,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[18,"Androida","ENU5:028 ",null,"Recessive",null,null,"Unknown",null,null,"Androida",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2006-08-19","Cryopreserved sperm",40,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Lina","Tze","lina.tze@anu.edu.au","j.APF.03.06","N/A","No"]
[2781,"C57BL/6.Flii 1.4A","B6.C-Flii<tm1Hdc>/2AnuApb","B6.C-Flii<tm1Hdc>/2AnuApb","Recessive","flightless I homolog (Drosophila)","Flii","Nil","Fli1, Fliih","MGI:1342286","targeted mutation 1, Hugh D Campbell","Flii<tm1Hdc>","MGI:2179825","11",{"$nulls":15},"No",{"$nulls":12},"Embryonic lethality at implantation: no embryos are recovered after E5.5; embryos develop normally until cellularization, the development arrests before completion of gastrulation blastocysts initiate uterine implantation but embryos fail to develop.embryonic growth arrest: development arrests during gastrulation","Enhanced wound healing: 3 days after a 1 cm full-thickness incision was made in the dorsal skin, surface wound area measurements show smaller, more contracted wounds than in wild-type mice. Length of neoepidermis is significantly greater in mutant animals, and percentage or re-epithelialization of wounds is greater at 5 days after wounding. By day 7, healing is comparable in mutants and wild-type","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown","10","11",null,"No","2008-02-16","Cryopreserved sperm",105,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[4468,"HB9-GFP","129-Tg(Mnx1-GFP)1Slp/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Samuel L Pfaff","Mnx1",{"$nulls":10},"Enhanced Green Fluorescent protein highlights motoneurons in the spinal cord.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"sib x sib","Yes","2009-02-22","Cryopreserved sperm",135,0,"ANU","143","false",null,"Stephen","Redman","The Australian National University","stephen.redman@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4732,null,"B6;B10Br;129-Cblb<tm1Pngr> Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes","transgene insertion 4, Christopher C Goodnow",{"$nulls":11},"T cell signalling defect",null,"C57BL/6 x C57BL/10.Br x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","1","2",null,"No","2009-04-19","Cryopreserved sperm",90,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[9,"Anaconda","ENU4:006 ",null,"Recessive",null,null,"Unknown",null,null,"Anaconda",null,null,"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Screened phenotype = positive for anti-nuclear antibodies",null,"C57BL/6 x C57BL/10.Br","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2004-04-20","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Lina","Tze","lina.tze@anu.edu.au","J.APF.03.06","N/A","No"]
[16,"Anaya","ENU5:134 ",null,"Recessive",null,null,"Nil",null,null,"Anaya",null,null,"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Phenotypic screen= positive for anti-nuclear antibodies",null,"C57BL/6 x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2",null,null,"No","2004-04-20","Cryopreserved sperm",30,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","lina.tze@anu.edu.au",{"$nulls":3},"Chris","Goodnow","lina.tze@anu.edu.au","J.APF.03.06","N/A","No"]
[5458,"ENU16China:051a ; Berty","C57BL/6JAnu-Prkdc<berty>/AnuApb","C57BL/6JAnu-Prkdc<berty>/AnuApb","Recessive","protein kinase, DNA activated, catalytic polypeptide  ","Prkdc","Reduced","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","rotein kinase, DNA activated, catalytic polypeptide; berty","Prkdc<berty>","MGI:5009121","16","ENSMUSG00000022672","ENSMUST00000023352","Prkdc-201","10326","10349","T to A","ENSMUSE00000129337","73","3442","Tyrosine to STOP",{"$nulls":4},"CAGAAGACAAGTGCAGAAATGGAAGCATATCCAGCACTTGTGGTGGAAAAAATGCTGAGAG","Yes",{"$nulls":12},"No B or T cells.",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","Yes","Poor",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm",48,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[7517,"HA-TetO","C57BL/6-Tg(tetO-CYP19A1)2/MarpApb",null,"Dominant",{"$nulls":25},"Human Aromatase ; human cytochrome P450, family 19, subfamily a, polypeptide 1","TetO",{"$nulls":10},"Normal; no phenotype","Normal; no phenotype","C57BL/6J","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-11-29","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Stuart","Ellem","Monash University","Stuart.Ellem@monash.edu",{"$nulls":6},"MARP/2011/070/BC","PC1-N61/09","No"]
[5743,"E2F7/E2F8 floxed -/- (339/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5742,"E2F7/E2F8 flox-/- x K14Cre.FVB ?????",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5744,"E2F8 flox-/- x K14Cre.FVB (339/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6315,"OT-II/Puma/Bim ","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)425Cbn",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":13},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3453","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6315,"OT-II/Puma/Bim ","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)425Cbn",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519 ","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":61},"N/A","N/A"]
[6703,"Gt3","B6.129-Gtf2ird1<tm1Hrd>/Ausb",null,"Recessive","general transcription factor II I repeat domain-containing 1 ","Gtf2ird1","Nil","Alb-c-myc line 166.8, Alb/c-myc line 166.8, BEN, binding factor for early enhancer, c-myc line 166.8, Cream1, ESTM9, GTF3, MusTRD1, Tg(Alb1-Myc)166.8Sst, WBSCR11","MGI:1861942","general transcription factor II I repeat domain-containing 1; targeted mutation 1, Edna Hardeman","Gtf2ird1<tm1Hrd>","MGI:4454555","5",{"$nulls":28},"Impaired coordinationAbnormal nervous system physiology:*Mice exhibit evidence of altered GABAergic neuronal function compared with wild-type mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2192","true",null,"Edna","Hardeman","The University of New South Wales","ehardeman@cmri.usyd.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3385,"Histamine receptor type 2 -/- ","B6.129P2-Hrh2<tm1Wtn>","B6.129P2-Hrh2<tm1Wtn>","Recessive","histamine receptor H2","Hrh2","Nil",null,"MGI:108482","histamine receptor H2; targeted mutation 1, Takeshi Watanabe","Hrh2<tm1Wtn>","MGI:2182949","13",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for a targeted null mutation exhibit enlarged folds in gastric mucosa, elevated serum gastrin levels, increased numbers of parietal and enterochromaffin-like cells, and lack of secretion of gastric acid in response to histamine or gastrin.Abnormal gastric mucosa morphology:* enterochromaffin-like (ECL) cells are increased in number and are found not only in the basal region, but also in the neck region and isthmus.* increase in H+, K+-ATPase negative cells in the isthmus and neck region.* histamine content in the gastric mucosa is elevated.* young mice (4 weeks old) in which hypertrophy of the oxyntic mucosa is not yet seen, exhibit a significant increase in cell proliferation in the mucosa.Abnormal gastric parietal cell morphology: parietal cells are increased in number, are smaller and contain enlarged secretory canaliculi with a lower density of microvilli and few typical tubulovesicles in the narrow cytoplasm.Increased thickness of gastric mucosa:* thickness of the oxyntic mucosa in the glandular region is increased in 16-week old mutants resulting in the formation of enlarged gastric folds.* change in mucosal thickness is most prominent in the isthmus and neck region.Decreased digestive secretion: induction of gastric acid secretion by histamine or gastrin is completely abolished, however carbachol still induced secretion.Abnormal stomach pH: basal gastric pH is normal, however elevation of gastric pH by administration of an Hrh2 antagonist, famotidine, is not observed.Increased circulating gastrin level: 12- to 18-week old mutants exhibit elevated serum gastrin levels (hypergastrinemia).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Brother x sister","No","2008-07-09","Cryopreserved sperm",150,0,null,null,"true",null,"Prue","Hart","Telethon Institute for Child Health Research","prueh@ichr.uwa.edu.au",{"$nulls":3},"Prue","Hart","prueh@ichr.uwa.edu.au","N/A","N/A","No"]
[5222,"C57.Lyn-/-uMT-/-","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Nil","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"No",{"$nulls":12},"Mice are B cell deficient, and do not develop autoimmune disease characteristics of lyn -/- mice.","Not Studied","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-09-29","Cryopreserved sperm",50,0,"Ludwig",null,"false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"031/08","040/2001 & 304","No"]
[5222,"C57.Lyn-/-uMT-/-","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","B6.129-Lyn<tm1Ard> Ighm<tm1Cgn>/Apb","Recessive","immunoglobulin heavy constant mu","Ighm",null,"BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","immunoglobulin heavy chain 6 (heavy chain of IgM); targeted mutation 1, University of Cologne","Ighm<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"No",{"$nulls":45},"031/08","040/2001 & 304"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, CD45 antigen, Cd45, Ly-5, Lyt-4, T200, lymphocyte antigen 5","MGI:97810",null,"Ptprc<a>",null,"1",{"$nulls":15},"Yes","transgene insertion 327, Birgit Ledermann",null,"High",{"$nulls":11},"C57BL/6 x SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-11",null,0,0,null,"ABS #013","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","peptidase C","Pepc","Unknown","Dip-1, Pep-3, Pep3","MGI:97541",null,"Pepc<b>",null,"1",{"$nulls":58},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A"]
[2353,null,"B6.SJL-Ptprc<a>Pep3<b>/Boy Tg(TcrLCMV)327Sdz Tcra<tm1Mom>",null,"Recessive","T-cell receptor alpha chain","Tcra","Nil","Tcr alpha, Tcralpha","MGI:98553","T-cell receptor alpha chain; targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":58},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A"]
[258,null,"C57BL/6-Dpp4<tm1>",null,"Recessive","dipeptidylpeptidase 4","Dpp4","Nil","Cd26, Dpp-4, THAM","MGI:94919","targeted mutation 1, Nicolai Wagtmann","Dpp4<tm1Nwa>","MGI:2150161","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-30",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","michael.Hall@arc.wa.gov.au",{"$nulls":3},"Michael","Hall","michael.Hall@arc.wa.gov.au","N/A","N/A","No"]
[238,"MLR39","FVB/N-Tg(Cryaa-cre)39Mlr/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 39, Mike Robinson","aA-crystallin with tyrosinase cassette",{"$nulls":10},"Nil.  Mice express Cre in lens fibres with very little ectopic expression elsewhere",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm",70,0,null,null,"false",null,"Robb","de Iongh","The University of Melbourne","r.deIongh@unimelb.edu.au",{"$nulls":3},"Robb","de Iongh","r.deIongh@unimelb.edu.au","N/A","N/A","No"]
[6951,"ENU19 WT:030:a:B6:G3","ANU:ENU19WT:030:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",27,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7519,"QSi5 - black","Quackenbush Swiss i5 - black",null,"Dominant",{"$nulls":37},"Superior fecundity. Large litter size even after 50 generations.Mean length of the septum primum or flap valve length (FVL) is linger in QSI5 mice compared to 129T2 - 1.13mm compared to 0.60mm - the mean length of the septum primum or flap valve length (FVL) is strongly inversely correlated with patent foramen ovale (PFO) incidence.Increased lactation.More efficient milk production.Increased platelet count: QSi5 was found to have a mean platelet count of 1062 × 109/L (SD = 8.2 × 109/L, n = 16) versus that of 581 × 109/L (SD = 79 × 109/L, n = 23) in CBA mice.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Ian","Martin","The University of Sydney","ian.martin@sydney.edu.au",{"$nulls":6},"N/A",null,"No"]
[5748,"EKLF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5749,"EKLF/GKLF",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5011,"Ova BCR","B6.129-Ova BCR Tg1",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",150,0,null,"xxx","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4098,null,"KRN:156",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model. Candidate gene position likely to be Chr 3 or 12.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"5",null,"No","2008-12-04","Cryopreserved sperm",106,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[4605,"mIMPα4FL (mid level expression)","C57BL/6-Tg(EGFP-Kpna4 full length)mid",null,"Dominant","karyopherin (importin) alpha 4","Kpna4","Unknown","IPOA3","MGI:1100848",{"$nulls":3},"Unknown",{"$nulls":15},"Yes","EGFP fused to full length Kpna4","Protamine 1","mid level expression",{"$nulls":9},"Fertility maybe reduced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm",72,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[17,"Andrea","ENU4strain:AT007",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Homogeneous anti-nuclear antibodies. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2004-04-20","Cryopreserved sperm",10,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Heather","Domaschenz","heather.domaschenz@anu.edu.au","J.APF.21.08","N/A","No"]
[5347,"B6.hCD4","C57BL/6-Tg(Cd4-CD4)2362Litt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":10},"CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","24",null,null,"No","2010-12-15","Cryopreserved sperm",50,0,null,null,"false",null,"James","McCluskey","The University of Melbourne","jamesm1@unimelb.edu.au",{"$nulls":3},"Catherine","Keech","clkeech@unimelb.edu.au","N/A","N/A","No"]
[4716,null,"129-Shh<tm1Chg>/AnuApb",null,"Recessive","sonic hedgehog","Shh","Unknown","Hhg1, Hx, Hxl3, M100081","MGI:98297","targeted mutation 1, Chin Chiang","Shh<tm1Chg>","MGI:1857796","5",{"$nulls":15},"Yes",{"$nulls":12},"Perinatal Lethality, most die just before birth. abnormal dorsal-ventral axis patterning: indistinct midline at E8.5. Notochord degeneration: rostral-to-caudal loss of notochord tissue. Decreased brain size: abnormal forebrain morphology, ventral forebrain structures are lost. Abnormal diencephalon morphology: most of the diencephalon as an identifiable structure is absent. Abnormal telencephalon morphology: the bilateral lobes of the telencephalon are fused to form a single midline structure.  Abnormal long bone morphology: absence or fusion of the paired distal limb bones. Abnormal humerus morphology: have a bony extension of the humerus in the forelimb. Absent fibula:the fibula is absent in the hindlimb. Absent tibia: the tibia is absent in the hindlimb. Abnormal axial skeleton morphology: most sclerotomal derivatives are absent. Abnormal craniofacial bone morphology: craniofacial bones are severely affected and almost entirely absent. Decreased rib number: most of the ribs are absent, with only 5-6 rib cartilages remaining. Absent vertebrae: most sclerotomal derivatives including the entire vertebral column are absent, with only 5-6 rib cartilages remaining. Absent cartilage: cartilage is absent at the elbow joint.  Abnormal optic vesicle formation: optic vesicles are fused at the midline at E9.5, the optic stalks are deficient or absent, and there is no invagination to form the double-layered optic cups",null,"129SvEv","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Het x 129SvEv","No","2009-04-08","Cryopreserved sperm",105,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[4717,"SmoTgR","C57BL/6-Tg(CMV-RFP/Smo)/MarpApb",null,"Dominant",{"$nulls":25},"red fluorescent protein tagged to Smoothened","cytomegalovirus (CMV)",{"$nulls":10},"Animals express red fluorescent protein, are viable and healthy.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","15","2","Mate positive RFP mice with wild type C57BL/6","No","2009-04-08","Cryopreserved sperm",90,0,"Monash",null,"false",null,"David","Watkins","Monash University","Neil.Watkins@med.monash.edu.au",{"$nulls":3},"David","Watkins","Neil.Watkins@med.monash.edu.au","N/A","N/A","No"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)","Csf2rb1","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, C Glenn Begley","Csf2rb<tm1Cgb>","MGI:2181245","15",{"$nulls":15},"Yes","colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)",null,"High",{"$nulls":9},"None detected","Normal","NOD/SCID","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"Matings of 2 transgenic non-sibling mice","Yes","2009-10-22","Cryopreserved sperm",105,0,null,null,"false",null,"Hayley","Ramshaw","Hanson Institute","hayley.ramshaw@imvs.sa.gov.au",{"$nulls":3},"Hayley","Ramshaw","hayley.ramshaw@imvs.sa.gov.au","N/A","N/A","No"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":58},"Hayley","Ramshaw","hayley.ramshaw@imvs.sa.gov.au","N/A","N/A"]
[4922,"Kylie","NOD.129/Sv-Tg(Csf2rb<Y575>) Csf2rb<tm1Cgb> Csf2rb<tm1Clsc> Prkdc<scid>/Apb",null,"Dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc",null,"DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":58},"Hayley","Ramshaw","hayley.ramshaw@imvs.sa.gov.au","N/A","N/A"]
[5346,"SS-01 ; Vegfd 2.2.36 (SS-01)","B6;129S1/Sv-Figf<tm1Mach>/Apb",null,"X-linked","c-fos induced growth factor","Figf","Nil","VEGF-D, Vegfd","MGI:108037","c-fos induced growth factor; targeted mutation 1, Marc G Achen","Figf<tm1Mach>","MGI:3576785","X",{"$nulls":28},"No abnormal phenotype detected: homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.Mice have reduced numbers of lymphatic vessels in lungs.","Normal","129S1/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","0",null,null,"No","2010-12-15","Cryopreserved sperm",100,0,null,null,"false",null,"Marc","Achen","Peter MacCallum Cancer Centre","marc.achen@petermac.org",{"$nulls":6},"010/09","040/2001 7 304","No"]
[7,"Alberta","C57BL/6JSfdAnu-Lepr<brta>/AnuApb","C57BL/6JSfdAnu-Lepr<brta>/AnuApb","Recessive","leptin receptor","LepR","Unknown","LEPROT, leptin receptor gene-related protein, OB-RGRP, obese-like, obl, Obr","MGI:104993","alberta","Lepr<brta>","MGI:3847119","4","ENSMUSG00000057722","ENSMUST00000037552","Lepr-001",{"$nulls":7},"101768248","10",null,null,"ACCAACGTGTGTCCTTCCTGACTCCGTAGGTACGTCAGACTATATTATGTATTTTCCTTA","Yes",{"$nulls":12},"Homozygotes develop severe obesity evident by 4-8weeks. 50% develop diabetes by 6 weeks of age.Homozygotes don't breed",null,"C57BL/6JSfdAnu","Yes","No","Yes","Yes","No","Yes","Yes","Good",null,"9",null,"No","2006-02-06","Cryopreserved sperm",57,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[7065,"Momme D41","FVB/NJ-MommeD41 Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, D41","MommeD41",{"$nulls":6},"16",{"$nulls":16},"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region","11 copies",{"$nulls":9},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD41<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24",null,0,0,"QIMR",null,"true",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[5224,"BALB.Lyn up/up STAT6 knockout mice; BALB.Lyn-Y508FSTAT6 -/-","BALB/c-Lyn<tm1Mhi> Stat6<tm1Aki>/Apb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Reduced","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Margaret Hibbs","Lyn<tm1Mhi>","MGI:2157016","4",{"$nulls":28},"Not well defined","Not defined","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-01","Cryopreserved sperm",50,0,"Ludwig",null,"true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"031/08","040/2001 &304","No"]
[5224,"BALB.Lyn up/up STAT6 knockout mice; BALB.Lyn-Y508FSTAT6 -/-","BALB/c-Lyn<tm1Mhi> Stat6<tm1Aki>/Apb",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":15},"No",{"$nulls":45},"031/08","040/2001 &304"]
[3401,"IL11R KO","B6.129-Il11ra1<tm1Wehi>/Wehi",null,"Recessive","interleukin 11 receptor, alpha chain 1","Il11ra1","Nil","Il-11ra, Il-11ra-alpha, Il11ra, NR1","MGI:107426","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Il11ra1<tm1Wehi>","MGI:2177778","4",{"$nulls":15},"No",{"$nulls":12},"Normal haemopoeisis. Female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization. A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-11 receptor alpha chain in the developing decidual cells. In both male and female IL-11Ralpha1-/- mice, trabecular bone volume was significantly higher than that of wildtype controls. This was associated with low bone resorption and low bone formation, and the low osteoclast number generated by IL-11Ralpha1-/- precursors was reproduced in ex vivo cultures, whereas elevated osteoblast generation was not.Embryonic lethality during organogenesis:* intercrosses of heterozygotes produce viable homozygous offspring at the expected Mendelian ratios.* however, embryos developing in homozygous mutant mothers appear necrotic at >7.5 dpc, with rare instances (<1%) of intact embryos detected at 9.5 dpc, and no live embryos found after 10.5 dpc.* notably, 2.5 dpc mutant embryos survive normally when transferred in foster uteri, whereas wild-type embryos fail to do so in uteri of mutant mice.Impaired embryo implantation:* at 4.5-7.5 dpc, homozygotes display a normal number of implantation sites relative to wild-type mice.* however, mutants show reduced capillary permeability and blood flow in the uterine vascular bed at the site of blastocyst apposition.Abnormal placenta development:* in most cases, embryos surviving in 9.5 dpc mutant uteri contain fibrinoid material and inflammatory cells in the space normally occupied by the placenta.* in a few cases, embryos surviving in 9.5 dpc mutant uteri display fetal components of the chorioallantoic placenta; however, the decidua basalis is entirely absent, being replaced by multiple layers of trophoblast giant cells, while the decidua capsularis is present but significantly thinner.Abnormal decidualization:* at 4.5 dpc, uteri of pregnant homozygotes display a reduced secondary decidual response to the implanting blastocystat 5.5-7.5 dpc, mutant deciduae are significantly smaller, displaying hemorrhage in the uterine lumen, disruption of the antimesometrium, and overgrowth of giant trophoblast cells in the mesometrial portion of the deciduum.* notably, pseudopregnant homozygotes show reduced deciduoma formation in response to an artificial (oil) stimulus, albeit with partial preservation of mesometrial decidual tissue.Increased trophoblast giant cell number: pregnant homozygotes exhibit a significantly increased number of secondary trophoblast giant cells in the mutant decidua.","Normal","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-07-13",null,0,0,null,"WEHI #69","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3946,"MommeD5","FVB/NJ-Hdac1<MommeD5>/Apb","FVB/NJ-Hdac1<MommeD5>/Apb","Semi-dominant","histone deacetylase 1","Hdac1","Unknown","HD1, RPD3","MGI:108086","modifier of murine metastable epialleles, D5","Hdac1<MommeD5>",null,"4",{"$nulls":15},"Yes","Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Lethality/prenatal-perinatalEmbryonic lethality during organogenesis* homozygotes die at or before E14.5EmbryogenesisEmbryonic growth arrest * around E8-9Embryonic growth retardation * developmentally delayed at E10.5Growth/sizeEmbryonic growth retardation* developmentally delayed at E10.5","Percentage of cells expressing the Line3 GFP transgene is decreased (enhancer of variegation).","FVB/NJ","No","No","Yes","No","No","Yes","No","Poor",null,null,"MommeD5<+/->;Tg(α-Globin-GFP)3EWh<tg/tg> x Tg(α-Globin-GFP)3EWh<tg/tg>","No","2008-10-17","Cryopreserved sperm",95,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whielaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[5809,"GHR 569",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6952,"ENU19 WT:031:a:B6:G3","ANU:ENU19WT:031:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4180,"mNET","C3H.FVB-Tg(Foxa2enhancer.β-globin-LacZ) ",null,"Dominant",{"$nulls":25},"lacZ (Beta-galactosidase)","mouse notochord Foxa2 enhancer element, β-globin minimal promoter",{"$nulls":10},"Normal. LacZ expressed in the 8.0 dpc notochord","Normal. LacZ expressed in the 8.0 dpc notochord","C3H/HeH","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-12-18","Cryopreserved sperm",50,0,null,null,"true",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[6704,"Gt4","B6.129-Gtf2ird1<tm2Hrd>/Ausb",null,"Recessive","general transcription factor II I repeat domain-containing 1","Gtf2ird1","Nil","Alb-c-myc line 166.8, Alb/c-myc line 166.8, BEN, binding factor for early enhancer, c-myc line 166.8, Cream1, ESTM9, GTF3, MusTRD1, Tg(Alb1-Myc)166.8Sst, WBSCR11","MGI:1861942","general transcription factor II I repeat domain-containing 1; targeted mutation 2, Edna C Hardeman MGI ID: \tMGI:3698407","Gtf2ird1<tm2Hrd>","MGI:3698407","5",{"$nulls":28},"Abnormal behavior:*Mice display some behavioral and neurological defects that mimic some aspects of the behavioral deficit of Williams syndrome.Craniofacial phenotype:*Unlike human patients with Williams syndrome, mice do not display craniofacial or dental abnormalities.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2193","true",null,"Edna","Hardeman","The University of New South Wales","ehardeman@cmri.usyd.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6814,"NOD-SBmut10","NOD/Lt-Tn(sb-pTrans-SA-IRESLacZ-CAG-GFP-SD:Neo)10TCB/Apb",null,"Recessive",{"$nulls":25},"TgTn(sb-pTrans-SA-IRESLacZ-CAG-GFP-SD:Neo)2TCB",{"$nulls":11},"unknown","unknown","NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2012-02-08","Cryopreserved sperm",50,0,"St V",null,"false",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":3},"Colleen","Elso","celso@svi.edu.au","052/09","STV IBC Protocol No 185, STV IBC Protocol No 186","No"]
[3947,"mommeD6","FVB/NJ-MommeD6/Apb",null,"Semi-dominant",null,null,"Unknown",null,null,"modifiers of murine metastable epiallele D6","MommeD6","MGI:3586553","14",{"$nulls":15},"Yes","Green fluorescent protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality (~9.5 dpc)","GFP transgene (Line3) expression levels are increased.","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD6<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2008-10-17","Cryopreserved sperm",75,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whielaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[5348,"NOD.hCD4","NOD-Tg(Cd4-CD4)2362Litt/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":10},"CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype.","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","24",null,null,"No","2010-12-15","Cryopreserved sperm",50,0,null,null,"false",null,"James","McCluskey","The University of Melbourne","jamesm1@unimelb.edu.au",{"$nulls":3},"Catherine","Keech","clkeech@unimelb.edu.au","N/A","N/A","No"]
[4131,"Line3c","C57BL/6-Tg(HBA1-GFP)3Ew/Apb",null,"Dominant",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No","Green Fluorescent Protein (GFP)","α-Globin (-570 to +37) (4.1kb of enhancer)",{"$nulls":10},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2008-12-07","Cryopreserved sperm",125,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whielaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[5021,"N1.C57BL6/J.Hep.516 KI/KI","C57BL/6J-Hep.516 KI/KI",null,"Dominant",{"$nulls":39},"7","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",105,0,null,null,"true",null,"Mark","Hulett","The Australian National University","mark.hulett@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4699,"NOD.Cg-Tg(RIP-Socs1)24Wehi NODPfp","NOD.Cg-Tg(Ins2-Socs1)24Wehi Prf1<tm1Sdz>/WehiApb",null,"Dominant","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfn, Pfp, Prf-1","MGI:97551","perforin 1 (pore forming protein); targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":15},"No","suppressor of cytokine signaling 1 (Socs1)","Rat insulin promoter from RIP7 vector",{"$nulls":10},"90–95% of  Pancreatic β cells did not up-regulate class I MHC in response to 100 U/ml IFN-, whereas all other islets cells were responsive, as measured by flow cytometry. SOCS-1 overexpression in  Pancreatic β cells prevents progression to diabetes in CD8+ TCR transgenic NOD8.3 mice",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",150,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[6322,"Puma/Bim/OT-1","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)1100Mjb",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 1100, Michael J Bevan","a 2-kb fragment of the H-2Kb promoter",{"$nulls":12},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3257","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6322,"Puma/Bim/OT-1","C57BL/6-Bbc3<tm1Ast> Bcl2l11<tm1Ast> Tg(TcraTcrb)1100Mjb",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":61},"N/A","N/A"]
[5349,"B6.IAE","C57BL/6-H2<dlAb1-Ea>/JApb",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No",{"$nulls":12},"Mice feature immune system perturbations including a dearth of CD4(+) lymphocytes in the thymus and spleen.Mice are susceptible to infection.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","36",null,"Het x Het","No","2010-12-15","Cryopreserved sperm",50,0,null,null,"true",null,"James","McCluskey","The University of Melbourne","jamesm1@unimelb.edu.au",{"$nulls":3},"Catherine","Keech","clkeech@unimelb.edu.au","N/A","N/A","No"]
[5350,"NOD.IAE","NOD-H2<dlAb1-Ea>/JApb",null,"Recessive","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No",{"$nulls":12},"Mice feature immune system perturbations including a dearth of CD4(+) lymphocytes in the thymus and spleen.Mice are susceptible to infection.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","41",null,"Het x Het","No","2010-12-15","Cryopreserved sperm",50,0,null,null,"true",null,"James","McCluskey","The University of Melbourne","jamesm1@unimelb.edu.au",{"$nulls":3},"Catherine","Keech","clkeech@unimelb.edu.au","N/A","N/A","No"]
[6719,"cre1","B6-Tg(CMV-cre)1Cgn/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, University of Cologne","human cytomegalovirus (CMV) promoter",{"$nulls":12},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2181","true",null,"Peter","Gunning","Moss Vale","p.gunning@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5316,"RKO 44","B6;129S1-Ryk<tm1Stac>/Apb",null,"Recessive","receptor-like tyrosine kinase","Ryk",null,"ERK-3, Vik","MGI:101766","receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker","Ryk<tm1Stac>","MGI:2667542","9",{"$nulls":28},"Neonatal lethality: most mice died within 1 day of birth, though some survived up to 8 days, and 2 to adulthood.Abnormal gait: mice surviving to adulthood dragged their hindlimbs.Short mandible.Abnormal maxilla morphology: in conjunction with shortened nasal bone, resulting in flattened midface.Abnormal neurocranium morphology: slightly smaller and rounder than that of wild-type or heterozygous mutant mice.Short nasal bone: shortened nasal bone, resulting in flattened midface.Cleft secondary palate: * cleft secondary palate observed in 88% of mice * consequence of abnormally high positioning and enlargement of the tongue.Increased tongue size: enlargement observed around E14, resulting in the disruption of the development of the palatal shelf.Short snout.Microcephaly: exhibited by mice that survived to adulthood.Cachexia.Postnatal growth retardation: growth was severely impaired in mice surviving past the first day of life.Cyanosis: mice were largely unable to suckle, became dehydrated, cyanotic, and exhibited gasping respirations.Short ulna: reduced in length.Abnormal hindlimb morphology: hindlimbs were splayed laterally.Short fibula.Short limbs: 18% to 25% reduction in the length of the long bones.Microphthalmia: bilateral microphthalmia was observed in mice that survived to adulthood.",null,"C57BL/6 X 129S1/Sv","No","No","Yes","No","No","Yes","No","Unknown","0",null,null,"No","2010-11-11","Cryopreserved sperm",50,0,"Ludwig",null,"false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria","Steven","Stacker","steven.stacker@petermac.org","003/09","040/2001 & 304","No"]
[5029,"Bertolino","DAS",null,"Recessive",{"$nulls":39},"1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",10,0,null,null,"true",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.usyd.edu.au",{"$nulls":6},"N/A","n/A","No"]
[6357,"NOD/SCIDeGFP","NOD.Cg-Prkdc<scid> Tg(ActBeGFP)/Ausb","NOD.Cg-Prkdc<scid> Tg(ActBeGFP)/Ausb","Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":16},"transgene insertion 1, Research Institute for Microbial Diseases, Osaka University","chicken beta actin promoter",{"$nulls":10},"The mayority of eGFP expressing mice develop normally.A proportion(7%) of the e-GFP had small bodies,with a body weight of only 50% of the NOD/SCID mice",null,"NOD SCID","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo",0,0,"Moss Vale","2608","true",null,"Andrew","Biankin","Garvan Institute","a.biankin@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[3948,"mommeD10","FVB/NJ-Baz1b<MommeD10>/Apb","FVB/NJ-Baz1b<MommeD10>","Semi-dominant","bromodomain adjacent to zinc finger domain, 1B","Baz1b","Unknown","Wbscr9, WSTF","MGI:1353499","modifier of murine metastable epialleles, D10","Baz1b<MommeD10>","MGI:3821601","5",{"$nulls":15},"Yes","Green Fluorescent Protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Most homozygotes die perinatally. One-fifth will survive to weaning and are occasionally fertile. Surviving homozygotes are mostly male and are small in size. Homozygotes display craniofacial abnormalities.Decreased body size: at weaning.Decreased fetal size: noticable in utero at E18.5.Short mandible: mandibular hypoplasia, particularly posteriorly.Micrognathia: mandibular hypoplasia.Small parietal bone: shortened 12% relative to controls.Short nasal bone: * shortened 12% relative to controls. * flattened.Abnormal palatine bone morphology: reduced in width.Malocclusion.Short snout: upward curvature of the nasal tip.Broad head: widened bulbous forehead.","Heterozygotes display subtle craniofacial abnormalities. Percentage of cells expressing the GFP transgene (Line3) is decreased (enhancer of variegation).Decreased litter size.Small parietal bone: shortened 12% relative to controls.Short nasal bone: * shortened 12% relative to controls. * flattened.Abnormal palatine bone morphology: reduced in width.","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD10<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2008-10-17","Cryopreserved sperm",100,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whielaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[7676,"CD4-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Tg(Cd4-Cre)1Cwi/JhmiAnu",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":16},"transgene insertion 1, Christopher B Wilson","CD4",{"$nulls":10},"Egr2 f/f.Egr3-/-.CD4-cre+ mice develop autoimmune disease at around three months of age or older.  Egr2 f/f.CD4-cre+ mice develop milder autoimmune disease and at a slower rate.  Egr3-/- exhibit some neurological defects.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2014-05-09","Cryopreserved sperm",21,0,"ANU",null,"true",null,"Ian","Parish","The Australian National University","ian.parish@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7676,"CD4-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Tg(Cd4-Cre)1Cwi/JhmiAnu",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14",{"$nulls":61},"N/A","N/A"]
[4604,"mIMPα2delta","C57BL/6-Tg(EGFP-Kpna2 dominant negative) ",null,"Dominant","karyopherin (importin) alpha 2","Kpna2","Unknown","Importin alpha, m-importin, m-importin-alpha-P1, pendulin, Rch1","MGI:103561",{"$nulls":3},"11",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","EGFP fused to dominant negative Kpna2","Protamine 1",{"$nulls":10},"Fertility maybe affected",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-03-13","Cryopreserved sperm",30,0,null,null,"true",null,"David","Jans","Monash University","David.Jans@med.monash.edu.au",{"$nulls":3},"David","Jans","David.Jans@med.monash.edu.au","N/A","N/A","No"]
[5330,"RKO C57BL/6","C57BL/6-Ryk<tm1Stac>/Apb",null,"Recessive","receptor-like tyrosine kinase","Ryk","Nil","ERK-3, Vik","MGI:101766","receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker","Ryk<tm1Stac>","MGI:2667542","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes die on the day of birth. Approx. 90% of E18.5 embryos have heart defects, the probable cause of neonatal death. They also have a cleft palate, craniofacial defects, shortened limbs and body axis, inner ear defects and abnormal corpus callosum (brain).Abnormal gait: mice surviving to adulthood dragged their hindlimbs.Short mandible.Abnormal maxilla morphology: in conjunction with shortened nasal bone, resulting in flattened midface.Abnormal neurocranium morphology: slightly smaller and rounder than that of wild-type or heterozygous mutant mice.Short nasal bone: shortened nasal bone, resulting in flattened midface.Cleft secondary palate: * cleft secondary palate observed in 88% of mice * consequence of abnormally high positioning and enlargement of the tongue.Increased tongue size: enlargement observed around E14, resulting in the disruption of the development of the palatal shelf.Short snout.Microcephaly: exhibited by mice that survived to adulthood.Cachexia.Postnatal growth retardation: growth was severely impaired in mice surviving past the first day of life.Cyanosis: mice were largely unable to suckle, became dehydrated, cyanotic, and exhibited gasping respirations.Short ulna: reduced in length.Abnormal hindlimb morphology: hindlimbs were splayed laterally.Short fibula.Short limbs: 18% to 25% reduction in the length of the long bones.Microphthalmia: bilateral microphthalmia was observed in mice that survived to adulthood.","Apparently normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-11-19","Cryopreserved sperm",50,0,"Ludwig",null,"false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria","Steven","Stacker","steven.stacker@petermac.org","003/09","040/2001 & 304","No"]
[4719,"TgAPP751 (Tg80.1 line)","B6.SJL-Tg(APP751)80.1Aust ",null,"Dominant","amyloid beta (A4) precursor protein","APP","Unknown","Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II, A4, AD1","MGI:88059",{"$nulls":3},"16",{"$nulls":15},"Yes","amyloid beta (A4) precursor protein","? moPrP, hamster prion protein promotor",{"$nulls":10},"? Transgene primarily expressed in brain. No overt phenotype, normal growth and breeding.",null,"? C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm",70,0,null,null,"true",null,"Qiao-Xin","Li","The University of Melbourne","q.li@unimelb.edu.au",{"$nulls":3},"Qiao-Xin","Li","q.li@unimelb.edu.au","N/A","N/A","No"]
[7710,"37L1iKO","B6.Cg-Gpr37L1<tm1d(EUCOMM)Wtsi> Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/JVccrApb",null,"Recessive","G protein-coupled receptor 37-like 1","Gpr37l1",null,"CAG-18, D0Kist8","MGI:1928503","G protein-coupled receptor 37-like 1; targeted mutation 1d, Wellcome Trust Sanger Institute","Gpr37L1<tm1d(EUCOMM)Wtsi>",null,"1",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25",null,0,0,"Victor Chang",null,"true",null,"Nicola","Smith","Victor Chang Cardiac Research Institute","n.smith@victorchang.edu.au",{"$nulls":6},"13/30","3025/2010","Yes"]
[6331,"Sey","C57BL/6-Pax6<Sey>",null,"Semi-dominant","paired box gene 6","Pax6","Nil","1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6","MGI:97490","paired box gene 6; small eye","Pax6<Sey>","MGI:1856155","2",{"$nulls":28},"Complete neonatal lethality:*Mice die soon after birth because of inability to breathe during suckling.Anophthalmia:*At E15, homozygotes have no visible eyes.Abnormal nasal cavity morphologyShort snout:*Defects in nasal cavity development results in shortened, imperforate snout.","Abnormal optic cup morphology:*At E15, fissure of optic cup is often delayed in closing.*At E15, there is folding at the margin of the optic cup resulting in a keyhole-shaped opening.Microphthalmia:*At E15 heterozygotes have smaller eyes than wild-type.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","474","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5756,"Emx1CreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7520,"QSi5 - albino","Quackenbush Swiss i5 - albino",null,"Dominant",{"$nulls":37},"Superior fecundity. Large litter size even after 50 generations.Mean length of the septum primum or flap valve length (FVL) is linger in QSI5 mice compared to 129T2 - 1.13mm compared to 0.60mm - the mean length of the septum primum or flap valve length (FVL) is strongly inversely correlated with patent foramen ovale (PFO) incidence.Increased lactation.More efficient milk production.Increased platelet count: QSi5 was found to have a mean platelet count of 1062 × 109/L (SD = 8.2 × 109/L, n = 16) versus that of 581 × 109/L (SD = 79 × 109/L, n = 23) in CBA mice.",null,"Quackenbush Swiss","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Ian","Martin","The University of Sydney","ian.martin@sydney.edu.au",{"$nulls":6},"N/A",null,"No"]
[6953,"ENU19 WT:034:a:B6:G3","ANU:ENU19WT:034:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",56,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4809,"Cooee","ENU8BAT:044",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[6954,"ENU19 WT:035:a:B6:G3","ANU:ENU19WT:035:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[86,"T-wimp","C57BL/6JSfdAnu-Lcp2<twm>/AnuApb","C57BL/6JSfdAnu-Lcp2<twm>/AnuApb","Recessive","lymphocyte cytosolic protein 2","Lcp2","Reduced","SLP-76, SLP76, twm","MGI:1321402","t-wimp","Lcp2<twm>","MGI:3614800","11","ENSMUSG00000002699","ENSMUST00000052413","Lcp2-001",{"$nulls":7},"33978410","12",null,null,"TGCAGCCCTCAGCCCCATTGGGGAGGTAAGTGTCTGTCATACTGTACCAAGTCCAGAATT","No",{"$nulls":12},"Few naïve CD4⁺ and CD8⁺ T cells, autoimmunity, 5 fold decrease in DP Tcells and significantly fewer CD4⁺ and CD8⁺ SP cells, partial block in T cell deveolpment at the Pre TCR checkpoint, very low expression of CD5 on DP thymocytes, defect in TCR signalling, mutation intrinsic to thymocytes, reduced expression of Slp76, Defects in positive selection and reduced negative thymocyte selection, hypergammaglobulinemia and hyper-IgE",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",142,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 117, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[4743,null,"B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","Semi-dominant","Ring finger and CCCH-type zinc finger domains 1","Rc3h1","Unknown","Roquin","MGI:2685397","sanroque","Rc3h1<san>","MGI:3581675","1",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":14},"C57BL/JAnu","Yes","No","Yes","Yes","No","Yes","No","Unknown",null,"1","Rc3h1<san/+> x ICOS -/-","No","2009-04-27","Cryopreserved sperm",90,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4743,null,"B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","B6.129-Rc3h1<san> Icos<tm1Flv>/AnuApb","Semi-dominant","inducible T-cell co-stimulator","Icos","Unknown",null,"MGI:1858745","targeted mutation 1, Richard A Flavell","Icos<tm1Flv>","MGI:2683635","1",{"$nulls":61},"N/A","N/A"]
[7677,"Egr2-GFP","C57BL/6-Egr2<Gfp>/JhmiAnu",null,"Dominant","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296",{"$nulls":3},"10",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-05-09","Cryopreserved sperm",11,0,"ANU",null,"true",null,"Ian","Parish","The Australian National University","ian.parish@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5352,"B6.SOD1.SOD3.Gpx1.Tg","C57BL/6-Tg(H2-K-GPX1,-SOD1,-SOD3/CD55)CCpj/Apb",null,"Dominant",{"$nulls":25},"human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag","H2-K<b>","medium",{"$nulls":9},"Expression of all three enzymes was the only combination protective against hypoxia/reoxygenation. In contrast to single- and double-transgenic grafts, triple-transgenic grafts significantly improved control of blood glucose compared with wild type. In contrast to single- and double-transgenic grafts, triple-transgenic grafts significantly improved control of blood glucose compared with wild type.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10",null,null,"No","2010-12-20","Cryopreserved sperm",45,0,"St V","008","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Lisa","Murray-Segal","Lisa.MURRAY-SEGAL@svhm.org.au","BGMML#21","094","No"]
[{"$nulls":30},"human extracellular superoxide dismutase (SOD3) modified to include a glycosyl phosphatidylinositol (GPI) membrane linkage signal & tagged with a FLAG epitope tag","H2-K<b>"]
[{"$nulls":30},"human cellular glutathione peroxidase (Gpx-1) tagged with a histidine (6xHis) tag","H2-K<b>"]
[122,"CD28 -/-","B6.129S2-Cd28<tm1Mak>/ThwAnuApb","B6.129S2-Cd28<tm1Mak>/ThwAnuApb","Recessive","CD28 antigen","CD28","Nil",null,"MGI:88327","targeted mutation 1, Tak Mak","Cd28<tm1Mak>","MGI:1857150","1",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutation of this gene results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",295,0,"ANU","032","false",null,"Edward","Bertram","The Australian National University","edward.bertram@anu.edu.au",{"$nulls":3},"Edward","Bertram","edward.bertram@anu.edu.au","J.APF.03.06","N/A","No"]
[6955,"ENU19 WT:040:b:B6:G3","ANU:ENU19WT:040:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6956,"ENU20:005:a:B6:G3","ANU:ENU20:005:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[294,"eotaxin<tm1> Tg(IL5)","C;B6-Ccl11<tm1Mer> Tg(CD2-Il5)5C2Ldt",null,"Dominant","small chemokine (C-C motif) ligand 11","Ccl11","Nil","eotaxin, Scya11","MGI:103576","chemokine (C-C motif) ligand 11; targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11",{"$nulls":15},"Yes","transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High",{"$nulls":9},"Eosinophil-deficient. Tumor incidence was greatly increased.Eotaxin(-/-) mice with or without the IL-5 transgene, were no more susceptible than WT or IL-5 Tg mice to protracted primary infections with Heligmosomoides bakeri, a parasitic nematode that is restricted to the gut. ",null,"BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"10",null,"No","2006-05-03",null,0,0,null,"ABS #072","true",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","Na","No"]
[279,null,"129-Ifnar<tm1Agt>/Apb",null,"Recessive","interferon (alpha and beta) receptor 1","Ifnar1","Unknown","CD118, Ifar, Ifrc, INF-a receptor, Infar","MGI:107658","Ifnar1<tm1Agt>","targeted mutation 1, Michel Aguet","MGI:1930950","16",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.",null,"129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-02","Cryopreserved sperm",100,0,"ANU","113","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"ASD",null,null,"N/A","N/A","No"]
[7707,"Adra1aflx","B6(Cg)-Adra1a<tm1c(EUCOMM)Hmgu>/MArpVccrApb",null,"Recessive","adrenergic receptor, alpha 1a","Adra1a",null,"Adra1c","MGI:104773","Adrenergic receptor, alpha 1a; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Adra1a<tm1c(EUCOMM)Hmgu>",null,"14",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25","Cryopreserved sperm",60,0,"Victor Chang",null,"true",null,"Nicola","Smith","Victor Chang Cardiac Research Institute","n.smith@victorchang.edu.au",{"$nulls":6},"12/37","3025/2010","Yes"]
[6958,"ENU20:007:a:B6:G3","ANU:ENU20:007:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[649,"HAP KO","Un.129-Hap1<tm1Xjl>",null,"Recessive","huntingtin-associated protein 1","Hap1","Nil","HAP-1","MGI:1261831","huntingtin-associated protein 1; targeted mutation 1, Xiao-Jiang Li","Hap1<tm1Xjl>","MGI:2670598","11",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:* most homozygotes die at 3 to 4 days after birth.* a few survive beyond 9 days of age, in the absence of skin, bone, or organ abnormalities* no homozygotes survive beyond 15 days of age.Absent gastric milk in neonates: mutant pups contain very little gastric milk, suggesting a feeding defect that may retard postnatal growth.Abnormal hypothalamus morphology:* at P1, TUNEL-positive cells are observed in the paraventricular nuclei (PVN) and the lateral hypothalamus (LH) of mutant but not wild-type mice; very few or no TUNEL-positive cells are noted in the arcuate nucleus (ARC) of mutant mice.* by P3, TUNEL-labeled cells are more widely spread in various regions of the hypothalamus which control eating, food intake, and energy metabolism, including the ventromedial hypothalamic nucleus (VMN).Neurodegeneration:* as early as P1, homozygotes display degeneration in specific regions of the hypothalamus that control feeding behavior, as determined by TUNEL staining.* in contrast, other brain regions (e.g. cortex, striatum, cerebellum, and hippocampus) display significantly fewer TUNEL-positive cells or show no difference relative to wild-type mice.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-04-25",null,0,0,null,null,"true",null,"Xin-Fu","Zhou","Flinders University","Xin-fu.zhou@flinders.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6879,"RBC14","FVB/NJ-Hbb-b1<MommeD7>/MarpApb",null,"Dominant","hemoglobin, beta adult major chain","Hbb-b1","Reduced","beta maj, beta major globin, beta1, beta-s","MGI:96021","hemoglobin, beta adult major chain; modifier of murine metastable epialleles, D7","Hbb-b1<MommeD7>","MGI:3821597","7",{"$nulls":28},"Lethal at E18.5 or just after (not present at birth). Embryos are normal until E16.5 where they manifest progressive pallor and reduced fetal liver cellularity.","Microcytic, hypochromic anemia with severe reticulocytosis. Compensatory erythropoiesis with splenic extramedullary hematopoiesis due to red cell destruction. ","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"Heterozygote intercrosses ","No","2012-04-26","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Fiona","Brown","Monash University","Fiona.Brown2@monash.edu",{"$nulls":3},"Fiona","Brown","fiona.brown2@monash.edu","B/BL-2011/371IL","PC2-N17/11","No"]
[7709,"37L1MCM","B6.Cg-Gpr37L1<tm1d(EUCOMM)Wtsi> Tg(Myh6-cre/Esr1*)1Jmk/JVccrApb",null,"Recessive","G protein-coupled receptor 37-like 1","Gpr37l1",null,"CAG-18, D0Kist8","MGI:1928503","G protein-coupled receptor 37-like 1; targeted mutation 1d, Wellcome Trust Sanger Institute","Gpr37l1<tm1d(EUCOMM)Wtsi>",null,"1",{"$nulls":16},"transgene insertion 1, Jeffery D Molkentin","mouse cardiac-specific alpha-myosin heavy chain","heart",{"$nulls":9},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-06-25","Cryopreserved sperm",60,0,"Victor Chang",null,"true",null,"Nicola","Smith","Victor Chang Cardiac Research Institute","n.smith@victorchang.edu.au",{"$nulls":6},"13/30","3025/2010","Yes"]
[7067,"Gardenia","FVB/NJ-Gardenia Tg(Hba1-Gfp)1Ew",null,"Semi-dominant","modifier of murine metastable epialleles, Gardenia",{"$nulls":4},"Gardenia",null,null,"16",{"$nulls":16},"Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Unknown","Unknown","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"Gardenia<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-24",null,0,0,"QIMR",null,"true",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[6636,null,"GALA-Supreme",null,"Dominant",{"$nulls":37},"To be determined by screening",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-10-25","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[652,"Activin Beta C+ FL1","C57BL/6-Tg(ACTIVIN-β{C})1Grb/Apb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human activin beta C","CMV","low (2 copies)",{"$nulls":9},"Essentially normal at gross level. male fertility decreases from 10 weeks (decreased sperm production, decreased liter size)","Essentially normal at gross level. male fertility decreases from 16 weeks (decreased sperm production, decreased liter size), evidence of liver disease and prostate hyperplasia","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",null,"3","Het x WT or Het x Het","No","2007-04-25","Cryopreserved sperm",70,0,null,null,"false",null,"Gail","Risbridger","Monash University","gail.risbridger@med.monash.edu.au",{"$nulls":3},"Elspeth","Gold","gail.risbridger@med.monash.edu.au","N/A","N/A","No"]
[7525,"B6.3R","B6.3R",null,"Recessive",{"$nulls":37},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A",null,"No"]
[5025,"Hulett 4(het) Knock-In","C57BL/6J-Hep.516 KI/WT ",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",100,0,null,null,"true",null,"Mark","Hulett","The Australian National University","Mark.hulett@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4784,"WT-127","WT Control for hGM-CSF transgenic mutants",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human GM-CSF","human GM-CSF promoter and enhancer (10.5kb)",{"$nulls":10},"Express human GM-CSF. hGM-CSF detected in serum by ELISA. Murine GM-CSF used as internal control.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",70,0,null,"ABS #182","false",null,"Frances","Shannon","The Australian National University","frances.shannon@anu.edu.au",{"$nulls":3},"Jim","Cakouros",null,"A.BS.01.09","N/A","No"]
[6722,"Sg1","B6.129-Sgca<tm1Kcam>/Ausb",null,"Recessive","sarcoglycan, alpha (dystrophin-associated glycoprotein) ","Sgca","Nil","50DAG, adhalin, Asg ","MGI:894698","sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell","Sgca<tm1Kcam>","MGI:1934922","11",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2197","true",null,"Peter","Gunning","Moss Vale","p.gunning@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1930,"OT-1","C57BL/6-Tg(TcraTcrb)1100Mjb",null,"Recessive",{"$nulls":25},"transgene insertion 1100, Michael J Bevan","H-2Kb promoter",{"$nulls":10},"Carries a transgenic T cell receptor that recognizes ovalbumin residues 257-264 (SIINFEKL) in the context of H2K<b>",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-23",null,0,0,null,"ABS #019 ; WEHI #254","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4792,"B6","C57BL/6J",null,"Dominant",{"$nulls":37},"Normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",80,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au","Building 117 Garran Rd Acton","Canberra","ACT",{"$nulls":3},"A.BS.01.09","N/A","No"]
[4793,"CBA","CBA",null,"Dominant",{"$nulls":37},"Normal.",null,"CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",10,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":6},"A.BS.01.09","N/A","No"]
[5135,null,"ENU14NIH:089:G3b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Skin continues to grow over the lifetime of the mouse","Normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","Unknown",{"$nulls":3},"No","2010-05-26","Cryopreserved sperm",9,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Alanna","Craven","Alanna.Craven@anu.edu.au","J.APF.13.08","N/A","No"]
[5227,"129Sv/Ly5.1","129/Sv-Ptprc<a>/Apb",null,"Dominant",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","N/A (homogenous wild type line)","N/A (homogenous wild type line)","129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"More than 10","Sibling mating","No","2010-10-05","Cryopreserved sperm",45,0,null,null,"false",null,"David","Curtis","Royal Melbourne Hospital","dcurtis@wehi.edu.au","C/O Royal Melbourne Hospital Post Office","Parkville","Victoria","Nhu-Y","Nguyen","nhnguyen@wehi.edu.au","2006.050","2008.03","No"]
[4795,"FVB","FVB/NJ",null,"Dominant",{"$nulls":37},"Normal.",null,"FVB/NJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",45,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au","Building 117 Garran Rd Acton","Canberra","ACT",{"$nulls":3},"A.BS.01.09","N/A","No"]
[4788,null,"129/SvJ",null,"Dominant",{"$nulls":37},"Normal.",null,"129/SvJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",73,0,"ANU","154","false",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au","Building 117, Garran Road","Acton","ACT","Alistair","Reid","alistair.reid@anu.edu.au","A.BS.01.09","N/A","No"]
[4790,null,"BALB/c",null,"Dominant",{"$nulls":37},"Normal.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",180,0,"ANU","3","false",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au","Building 117, Garran Road","Acton","ACT",{"$nulls":3},"A.BS.01.09","N/A","No"]
[6206,"vabl40/266Del","STOCK Bcl2l11<tm1.1Ast> Tg(Igh-Abl1)40Sco",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":16},"transgene insertion 40, Suzanne Cory","SV40 early promoter",{"$nulls":10},"Low incidences of plasmacytoma. Look out for dragging hind legs, enlarged spleen, enlarged mesenteric lymph nodes - tumours. Visually check.   1-2% will die at 20 weeks of age, 19-20% will die at 1 year. Mice die as a result of plasmacytoma. Mice will bear one of the following tumours: lymphoma, splenomegaly, messentary associated, abdominal, caecal, Peyer's Patches. They may also suffer from small bowel obstruction, intestinal haemorrhage, hind leg paralysis, intussusception,  vabl40 mice develop plasmocytoma tumours. Onset may be accelerated in Bim -/- vabl40 T/+ and Bim +/- vabl40 T/+  Bim -/- develop autoimmune kidney disease when older.",null,"Unknown","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1651","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5482,"TGF (-/-)  L-05","STOCK Tgfa<tm1Ard>/LudApb",null,"Recessive","transforming growth factor alpha","Tgfa",null,null,"MGI:98724","transforming growth factor alpha; targeted mutation 1, Ashley R Dunn","Tgfa<tm1Ard>","MGI:1856577","6",{"$nulls":15},"No",{"$nulls":12},"Increased incidence of corneal inflammation.Eyelids open at birth.Increased incidence of corneal inflammation.Waved hair: attenuated slightly with age.Increased curvature of hairs.Abnormal hair follicle orientation.Curly vibrissae: attenuated slightly with age.","Normal","Un","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-04-14","Cryopreserved sperm",50,0,"Ludwig","L-05","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"018/09","040/2001 & 304","No"]
[6439,"A2?","B6.129P2-Arnt2<tm1Yfk>/Ausb",null,"Recessive","aryl hydrocarbon receptor nuclear translocator 2","Arnt2","Nil","bHLHe1, mKIAA0307","MGI:107188","aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, Yoshiaki Fujii-Kuriyama","Arnt2<tm1Yfk>","MGI:2178831","7",{"$nulls":28},"Complete postnatal lethality:*No homozygotes survive to 2 weeks after birth.*Homozygotes within 1 day of birth are grossly normal.Abnormal neurohypophysis morphology:*Arginine vasopressin and oxytocin absent in the posterior lobe.*Corticotropin releasing hormone and somatostatin absent in the posterior lobe. Abnormal pituitary secretion:*Arginine vasopressin and oxytocin absent in the posterior lobe.*Corticotropin releasing hormone and somatostatin absent in the posterior lobe .Enlarged third ventricle:*Diameter of third ventricle is increased.Abnormal paraventricular hypothalamic nucleus morphology:*Hypocellular in newborn mice.Abnormal supraoptic nucleus morphology:*Hypocellular in newborn mice.Abnormal pituitary hormone level:*Arginine vasopressin and oxytocin absent in the posterior lobe.*Corticotropin releasing hormone and somatostatin absent in the posterior lobe.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","667","true",null,"Jenny","Gunton","Garvan Institute","j.gunton@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6449,"VDRJ?","B6.129S4-Vdr<tm1Mbd>/JAusb",null,"Recessive","vitamin D receptor","Vdr","Nil","Nr1i1","MGI:103076","vitamin D receptor; targeted mutation 1, Marie B Demay","Vdr<tm1Mbd>","MGI:2183404","15",{"$nulls":28},"Abnormal mineral homeostasis:*hypophosphatemia.Increased width of hypertrophic chondrocyte zone:*Expansion of the growth plate is associated with impaired apoptosis of late hypertrophic chondrocytes.Abnormal chondrocyte morphology:*Impaired hypertrophic chondrocyte apoptosis.*A 'rescue diet' of high-calcium/low-phosphate restores the normal level of apoptosis and the growth plate phenotype.Rickets:*Mutants develop rickets secondary to impaired apoptosis of late hypertrophic chondrocytes.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","762","true",null,"Jenny","Gunton","Garvan Institute","j.gunton@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[168,"Elf3 knockout","B6.129S4-Elf3<tm1Pjh>/Apb","B6.129S4-Elf3<tm1Pjh>/Apb","Recessive","E74-like factor 3","Elf3","Nil","ESE-1, ESX, jen","MGI:1101781","targeted mutation 1, Paul J Hertzog","Elf3<tm1Pjh>","MGI:2662485","1",{"$nulls":15},"Yes","Neomycin resistance gene",{"$nulls":11},"embryonic lethality during organogenesis: only about 71% of expected numbers of homozygotes are still alive at E11.5postnatal lethality: by weaning, only about 27% of expected numbers are still alive.decreased body size: smaller than controls during suckling period although normal in size from E11.5 to birth. After 6 weeks of age, weight gain is normal and mice attain normal sizecachexia: 2-3 days before death, mice begin to display a wasted phenotype, appear malnourished, lethargic, watery diarrhoealethargy: beginning 2-3 days before deathabnormal intestinal epithelium morphology: intestinal endothelium fails to transform from pseudostratified to columnar by E17.5. Formation of villi is delayed and those present are misshapen. Connective tissue under the lamina propria of the villi is disorganized.abnormal enterocyte morphology: absorptive enterocytes are morphologically abnormal. Tightly packed with apical cytoplasmic snouts. Microvilli are short. Increased numbers of mitochondria and ribosomes.abnormal intestinal goblet cells: reduced numbers of goblet cells producing sialomucin.diarrhoea: watery diarrhea in mice that die starting 2-3 days before death. ","No over phenotype","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10",null,"Het x Het OR Het male x WT female OR Het female x WT male","No","2006-04-15","Cryopreserved sperm",60,0,null,null,"false",null,"Melanie","Pritchard","Monash University","melanie.pritchard@med.monash.edu.au",{"$nulls":3},"Melanie","Pritchard","melanie.pritchard@med.monash.edu.au","N/A","N/A","No"]
[5228,null,"Osr-1 GFP",null,"Dominant","odd-skipped related 1 (Drosophila)","Osr1",null,"Odd1","MGI:1344424",{"$nulls":3},"12",{"$nulls":15},"Yes",{"$nulls":12},"Kidney abnormality","Normal","CD1","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-05","Cryopreserved sperm",50,0,"UQ",null,"false",null,"Melissa","Little","The University of Queensland","m.little@imb.uq.edu.au","306 Carmody Rd, UQ, St Lucia","Brisbane","Qld","Fiona","Rae","f.rae@imb.uq.edu.au","IMB/145/10/NHMRC (NF)","N/A","No"]
[4794,"CBA x B6","CBA/CaJ x C57BL/6J:F1",null,"Dominant",{"$nulls":37},"Normal.",null,"CBA x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",3939,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au","Building 117 Garran Rd Acton","Canberra","ACT",{"$nulls":3},"A.BS.01.09","N/A","No"]
[5398,"HK1-Shh","B6;CBA-Tg(KRT1-Shh)/Apb",null,"Dominant",{"$nulls":25},"rat sonic hedgehog","human keratin 1 ","increased",{"$nulls":9},"Unknown","skin anomalies, fore- and hindlimp abnormalities","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"het x wt","No","2011-01-27","Cryopreserved sperm",60,0,"UQ",null,"false",null,"Brandon","Wainwright","The University of Queensland","b.wainwright@imb.uq.edu.au","306 Carmody Rd","St Lucia","QLD","Elaine","Julian","e.haase@uq.edu.au","IMB/869/08/IMB/BREED","IBC/586/IMB/2008","No"]
[1969,"available from Animal Resources Centre - www.arc.wa.gov.au","BALB/c Series (H2<b>, H2<k>) ",null,"Dominant","Congenic albino: A, Tyr<c>, Tyrp1<b>, Congenic partner BALB/c.",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"General Information: Note inbred BALB/c except for usage where histocompatibility differences will be noted between strains.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"Yes","2007-09-04",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[4800,"Rain ; ENU11B6:226b","C57BL/6JAnu-Ptprc<rain>/AnuApb","C57BL/6JAnu-Ptprc<rain>/AnuApb","Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, Ly-5, Lyt-4, T200 ","MGI:97810","rain","Ptprc<rain>","MGI:4819248","1","ENSMUSG00000026395","ENSMUST00000027645","Ptprc-201",{"$nulls":7},"140007727","11",null,null,"TGTTATAAATGTGCAGACAGATTTGGGGAGTAAGTATATCGTTTATGTTTATAAAATAAA","Yes",{"$nulls":12},"Shifted CD45 expression measured by flow cytometry",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-10","Cryopreserved sperm",75,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","J.APF.14.08","N/A","Yes"]
[237,"MLR10","FVB/N-Tg(Cryaa-cre)10Mlr/Apb",null,"Dominant",{"$nulls":25},"transgene insertion 10, Mike Robinson","modified alpha A crystallin promoter with an inserted copy of Pax6 consensus binding site",{"$nulls":10},"Nil. Mice express Cre in lens, vibrissae. Weak expression in maxillary arch at E12.5.  ",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm",70,0,null,null,"false",null,"Robb","de Iongh","The University of Melbourne","r.deIongh@unimelb.edu.au",{"$nulls":3},"Robb","de Iongh","r.deIongh@unimelb.edu.au","N/A","N/A","No"]
[246,"B6.B2m-/-","B6.129S2-B2m<tm1Jae>/AnuApb","B6.129S2-B2m<tm1Jae>/AnuApb","Recessive","beta-2 microglobulin","B2m","Nil","beta 2 microglobulin, beta2-m, Ly-m11","MGI:88127","targeted mutation 1, Rudolf Jaenisch","B2m<tm1Jae>","MGI:1927183","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-26","Cryopreserved sperm",110,0,"ANU","145","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","A.BS.01.09","N/A","No"]
[8478,"ASD777:TNFRSF13b:C76R","C57BL/6NCrlAnu-Tnfrsf13b<em1Anu>/AnuApb",null,"Recessive","tumor necrosis factor receptor superfamily, member 13b","Tnfrsf13b","Unknown","1200009E08Rik, Taci","MGI:1889411",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-30","Cryopreserved sperm",33,0,"ANU","777","false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[6728,"GFP1","C57BL/6-Tg(CAG-EGFP)1Osb/J/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Research Institute for Microbial Diseases, Osaka University ","chicken beta actin promoter",{"$nulls":10},"Complete prenatal lethality:*Homozygous transgenic mice die in the embryonic stage, putatively due to integration site effect.","No abnormal phenotype detected:*Mice are viable and show no functional or morphological abnormalities of the retina.*All tissues, except for erytrhocytes and hair, are green under excitation light.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2340","true",null,"Peter","Gunning","The University of New South Wales","p.gunning@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4490,"EphA1 conditional transgenic","B6.129-Tg(Ubc-Epha1)1Sld",null,"Dominant",{"$nulls":25},"Eph receptor A1","Ubiquitin C","2.5x  wildtype in tissue tested by QPCR",{"$nulls":11},"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"hemizygote x wildtype","No","2009-02-24","Cryopreserved sperm",100,0,null,null,"true",null,"Andrew","Boyd","Queensland Institute of Medical Research","andrew.boyd@qimr.edu.au",{"$nulls":3},"Shannon","Duffy","Shannon.Duffy@qimr.edu.au","N/A","N/A","No"]
[5203,"ENU15 NIH 17","ENU15NIH:017",null,"Dominant","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Kinked tail. Mice have variable types of kinks, some with a small kink at the end of the tail, and others with either a pronounced or slight zigzag. ","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,"3","affected x B6","No","2010-08-09","Cryopreserved sperm",50,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Alanna","Craven","Alanna.Craven@anu.edu.au","J.APF.13.08","N/A","No"]
[210,"NRG1 TM/TM","NRG1 TM/TM",null,"Recessive","neuregulin 1","Nrg1","Nil","GGF, GGFII, heregulin, HGL, Hgl, HRG, HRGalpha, NDF, SMDF, ARIA","MGI:96083",{"$nulls":3},"8",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic NRG1 TM/TM mice die at E10.5 due to severe cardiac defects (lack of cardiac trabeculae). They also have impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells.","Heterozygotes are hyperactive with reduced NMDA receptors.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[5205,"theoden ; ENU4AT:050 ","B6JAnu(Cg)-Fas<theo>/AnuApb","B6JAnu(Cg)-Fas<theo>/AnuApb","Recessive","Fas (TNF receptor superfamily member 6)","Fas","Nil","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","theoden","Fas<theo>","MGI:4455060","19","ENSMUSG00000024778","ENSMUST00000025691","Fas-201","416","422","G to A","ENSMUSE00000144910","4","139","Cysteine to Tyrosine",{"$nulls":4},"CTACTGCGATTCTCCTGGCTGTGAACACTGTGTTCGCTGCGCCTCGTGTGAACATGGAACC","Yes",{"$nulls":12},"Antinuclear autoantibodies, lymphadenopathy.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2010-08-13","Cryopreserved sperm",104,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","J.APF.13.08","N/A","No"]
[209,"Tie2-Cre","C57BL/6-Tg(Tek-cre)12Flv",null,"Dominant",null,null,"Normal",{"$nulls":5},"Unknown",{"$nulls":15},"Yes","transgene insertion 12, Richard A Flavell","mouse endothelial-specific receptor tyrosine kinase promoter/enhancer","Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells.",{"$nulls":9},"Expression in endothelial cells during embryogenesis and adulthood.Hemizigous mice for transgenic insert are viable and fertile.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[214,"Cryptic","C57BL/6-Cfc1<tm1Mms>",null,"Recessive","cripto, FRL-1, cryptic family 1","Cfc1","Nil","cryptic","MGI:109448","targeted mutation 1, Michael M Shen","Cfc1<tm1Mms>","MGI:2179530","1",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal.      postnatal lethality (J:58104)homozygous mutant mice died within the first 2 weeks after birth, probably because of cardiac abnormalitieslife span/agingpremature death (J:58104)five homozygotes (from >90) survived past weaningcardiovascular systemabnormal direction of looping morphogenesis (J:58104)at 8.5-9.5 dpc, mutant embryos exhibited randomization of cardiac loopingat these stages, abnormal cardiac looping and embryo turning were highly correlateddextrocardia (J:58104)in 36% of mutant mice, the cardiac apex pointed to the right as opposed to the normal leftmesocardia (J:58104)in 12% of mutant mice, the cardiac apex pointed to the middle as opposed to the normal leftabnormal atrial septum morphology (J:58104)88% of mutant mice displayed septal defectsabnormal aorta morphology (J:58104)in wild-type mice, the aorta is dorsal to the pulmonary artery and connects to the left ventricle; in contrast, the mutant aorta was ventral to the pulmonary artery and connected to the right ventricleabnormal patterning of the aortic arch (J:58104)the mutant azygos vein could be located on the left side while the aorta arched to the left (as in wild-type), on the right while the aorta arched rightward, or bilaterally while the aorta arched leftwarddigestive/alimentary systemabnormal stomach morphology (J:58104)many newborn homozygotes exhibited a milk spot on their right side, instead of the leftembryogenesisabnormal direction of embryo turning (J:58104)at 8.5-9.5 dpc, homozygous mutant embryos exhibited randomization of embryo turningabnormal left-right axis patterning (J:58104)E18.5 and neonatal mutant mice (<1 week of age) displayed left-right laterality defects including heterotaxia, randomization of organ situs, and isomerism of bilaterally asymmetric tissuesgrowth/sizeright pulmonary isomerism (J:58104)100% of mutant mice displayed right pulmonary isomerismsitus inversus (J:58104)approximately 50% of homozygotes exhibited inverted situs of visceral organs including the stomach, spleen, and pancreashematopoietic systemabsent spleen (J:58104)100% homozygotes exhibited asplenia or severe hyposplenia","Viable and fertile","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[5633,"Backcross B6xCav-1 KO",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[216,"Nodal floxed","Nodal<tm1Mku>",null,"Dominant","Nodal","Nodal","Unknown","early embryo mesoderm formation, Tg.413d","MGI:97359","targeted mutation 1, Michael R Kuehn","Nodal<tm1Mku>","MGI:2158730","10",{"$nulls":15},"Yes",{"$nulls":12},"The floxed allele is hypomorphic. Mice homozygote for this floxed allele are viable and fertile. ",null,"C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-24",null,0,0,null,null,"true",null,"Richard","Harvey","Victor Chang Cardiac Research Institute","r.harvey@victorchang.edu.au",{"$nulls":3},"Richard","Harvey","r.harvey@victorchang.edu.au","N/A","N/A","No"]
[249,null,"Balb/c-Cd40<tm1Kik>/Apb",null,"Recessive","CD40 antigen","Cd40","Unknown","Bp50, Cd40, p50, Tnfrsf5","MGI:88336","targeted mutation 1, Hitoshi Kikutani","Cd40<tm1Kik>","MGI:1857457","2",{"$nulls":15},"Yes",{"$nulls":12},"Absence of germinal center formation in response to TI-I antigen stimulation. Defective IgM and IgG response to TI antigen and TD antigen stimulation. Decreased IgG2b",null,"Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-26","Cryopreserved sperm",105,0,"ANU","125","false",null,"Paul","Foster","The University of Newcastle","Paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[4805,"Akama","ENU8BAT:022",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",45,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[6500,"PKCET2?","B6.129T2-Prkce<tm1Ltg>/Ausb",null,"Recessive","protein kinase C, epsilon","Prkce","Nil","5830406C15Rik, PKC[e], Pkce, PKCepsilon","MGI:97599","protein kinase C, epsilon; targeted mutation 1, Michael Leitges","Prkce<tm1Ltg>","MGI:2680163","17",{"$nulls":28},"Unknown","Unknown","129T2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","275","true",null,"Carsten","Schmitz-Peiffer","Garvan Institute","c.schmitz-peiffer@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7031,"APN 235","C57BL/6N-Cdcp1<tm1(KOMP)Wtsi>/Marp",null,"Recessive","CUB domain containing protein 1","Cdcp1 ","Unknown","9030022E12Rik, E030027H19Rik ","MGI:2442010 ","CUB domain containing protein 1; targeted mutation 1, Wellcome Trust Sanger Institute ","Cdcp1<tm1(KOMP)Wtsi>","MGI:4419722","9",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N ","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-07-30","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MAS/MAS/2010/08","PC1-N09/07","No"]
[7711,"H2A.Lap1:NM10","FVB/NJArc-H2afb2<d5> H2afb3<d160> Gm14920<d17>/AnuApb",null,"X-linked","H2A histone family, member B2","H2afb2","Nil","EG624153, H2A.Bbd4, H2afb2-ps (lap1c)","MGI:3644980",{"$nulls":3},"X",{"$nulls":28},"Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","Normal. Small percentage dies when reaches the age of 7-9 months. Under investigation","FVB/NJArc","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"het to wt; homo to wt; homo to homo","No","2014-06-30","Cryopreserved sperm",105,0,"ANU",null,"false",null,"David","Tremethick","The Australian National University","david.tremethick@anu.edu.au",{"$nulls":3},"Tatiana","Soboleva","tanya.soboleva@anu.edu.au","A2066/11",null,"Yes"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[7523,"NOD.Beta","NOD-Tg(TcrVβ11<b>)1Gem/ArcApb",null,"Dominant",{"$nulls":25},"T cell receptor",{"$nulls":11},"Normal",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A","N/A","No"]
[7713,"Zdhhc2","C57BL/6N-Zdhhc2<tm1a(KOMP)Wtsi>/MarpApb",null,"Dominant","zinc finger, DHHC domain containing 2","Zdhhc2","Nil","5730415P04Rik, 6430583A19Rik","MGI:1923452","zinc finger, DHHC domain containing 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Zdhhc2<tm1a(KOMP)Wtsi>","MGI:4362764","8",{"$nulls":28},"wildtype","wildtype","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","2","4",null,"No","2014-07-01","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":3},"Lynelle","Jones","Lynelle.Jones@monash.edu","SOBS/B/2009/BC","PC1-N26/10","No"]
[7375,"ENU19:B6:Mlkl","C57BL6NCrlAnu-Mlkl<m1Anu>/Anu",null,"Recessive","mixed lineage kinase domain-like","Mlkl",null,"9130019I15Rik","MGI:1921818",null,"Mlkl<m1Anu>",null,"8","ENSMUSG00000012519","ENSMUST00000120432","Mlkl-002","949","1305","T to A","ENSMUSE00000214984","7","317","Arginine to STOP",{"$nulls":4},"ACAGGCTACACCATTCGGAAACACTCCACAGAAACATCAGCAGCTCCAGTTTCCTCGTAGC",{"$nulls":15},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-11","Cryopreserved sperm",30,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[4821,"Myndee","ENU8CAT:017",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",45,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[3419,"OT-1 / Bim KO","C57BL/6-Bcl2l11<tm1.1Ast> Tg(TcraTcrb)1100Mjb/Wehi",null,"Dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Andreas Strasser","Bcl2l11<tm1.1Ast>","MGI:2156498","2",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan","H-2Kb promoter",{"$nulls":10},"Cross used to create Bim knockout,  OVA specific CD8 T cells.Bim -/-   females often lack vaginal opening.",null,"C57BL/6","No","No","Yes","Yes","No","Yes","No","Unknown","10",null,null,"No","2008-07-14",null,0,0,null,"WEHI #138","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6489,"VILcre","B6.SJL-Tg(Vil-cre)997Gum/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 997, Deborah L Gumucio","A 12.4-kb promoter fragment from the villin 1 gene",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","551","true",null,"Maija","Kohonen-Corish","Garvan Institute","m.corish@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[5912,"Min Chen Tubbs",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4828,"6AT:062","ENU6AT:062",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",90,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[5646,"C3aR Het",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4832,"6CAT:006","ENU6CAT:006",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR x CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[7526,"B6.IJ","B6.IJ",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"6","Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-11-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A",null,"No"]
[4818,"Mani","ENU8BAT:092",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Mice carrying the ins-HEL gene have a subclinical predisposition to diabetes due to islet cell failure. Mice carrying the insHEL and TCR transgenes have asubclinical predisposition to autoimmune destruction of the beta cell. Screening mice by urine glucose test. High glucose levels indicate diabetes and thus autoimmunity. \"Early onset diabetes\" definition changed during screen from approx 80 days to 40 days.",null,"C57BL/6 x C57BL/10BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Breed diabetic Double transgenic with a non transgenic sib for next generation","No","2009-09-24","Cryopreserved sperm",75,0,null,null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.09.07","N/A","No"]
[7513,"Epo-R-Cre R26eYFP Recql4fl/fl","STOCK Epor<tm1(EGFP/cre)Uk> Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos>/StVApb","STOCK Epor<tm1(EGFP/cre)Uk> Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos>/StVApb","Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26 ","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sortm1(EYFP)Cos","MGI:2449038","6",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC044/10","IBC166"]
[7513,"Epo-R-Cre R26eYFP Recql4fl/fl","STOCK Epor<tm1(EGFP/cre)Uk> Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos>/StVApb","STOCK Epor<tm1(EGFP/cre)Uk> Recql4<tm2272Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos>/StVApb","Dominant","RecQ protein-like 4","Recql4","Normal",null,"MGI:1931028 ","Recql4tm2272Arte","Recql4 fl/fl",null,"15",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC044/10","IBC166"]
[6520,"2CLY5.1tg","B6.SJL-Ptprc<a> Tg(Tcra2C,Tcrb2C)1Dlo/Ausb",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":16},"transgene insertion 1, Dennis Y Loh",{"$nulls":11},"Abnormal CD8-positive T cell morphology: CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen.",null,"C57BL/6 x SJL","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","399","true",null,"Jonathan","Sprent","Garvan Institute","j.sprent@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[5108,"Plt20","B6.C-Bcl2l1<Plt20>/WehiAnuApb",null,"Recessive","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; platelet 20","Bcl2l1<Plt20>","MGI:3847887","2","ENSMUSG00000007659","ENSMUST00000109820","Bcl2l1-201","44","437","A to G","ENSMUSE00001233620","2","15","Tyrosine to Cysteine",{"$nulls":4},"CCGGGAGCTGGTGGTCGACTTTCTCTCCTACAAGCTTTCCCAGAAAGGATACAGCTGGAGT","No",{"$nulls":12},"Decreased platelet cell number: * platelet counts are 25% of normal * splenectomy only partially restored platelet cell countExtramedullary hematopoiesis: there is a slight increase in splenic erythropoiesis.Increased megakaryocyte cell number: megakaryocyte numbers are significantly elevated compared to controls.Abnormal platelet physiology: platelet half-life is reduced to under 12 hours compared to 57 hours for controls.","Decreased platelet cell number: platelet counts are significantly lower than controls (598x10<3>/microliter vs 1100x10<3>/microliter).Increased megakaryocyte cell number: megakaryocyte numbers are marginally elevated compared to controls.Abnormal platelet physiology: platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours).","BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-04","Cryopreserved sperm",40,0,"ANU",null,"false",null,"Ben","Kile","Walter and Eliza Hall Institute of Medical Research","kile@wehi.edu.au",{"$nulls":3},"Lucy","Coupland","lucy.coupland@anu.edu.au","N/A","N/A","No"]
[4858,"Jersey","ENU8CAT:049",null,"Dominant","two pore channel 1","Tpcn1","Unknown",null,"MGI:2182472",{"$nulls":3},"5","ENSMUSG00000032741","ENSMUST00000046426","Tpcn1-201",{"$nulls":7},"120989697","23",null,null,"TTTATCATGCTCTAGTGGAAGCCTCCCTGTGCCCCCTGACAGGCTCTGGGTATCTGACTA","Yes",{"$nulls":42},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A"]
[7718,"MUL1","MULAN","MUL1","Dominant","mitochondrial ubiquitin ligase activator of NFKB 1","Mul1",null,"0610009K11Rik","MGI:1915600",{"$nulls":3},"4",{"$nulls":28},"Mice are slightly smaller in size but appear healthy and behave normally","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2014-07-18","Cryopreserved sperm",60,0,"Monash",null,"true",null,"Ashley","Mansell","MIMR-PHI Institute of Medical Research","ashley.mansell@monash.edu",{"$nulls":3},"Ashley","Mansell","ashley.mansell@monash.edu","MMCA/2008/25/BC",null,"No"]
[6382,"GREENtg","C57BL/6-Tg(UBC-GFP)30Scha/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2497","true",null,"Robert","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7052,"ENU14:C3H007 G2","ENU14:C3H:007:G2",null,"Semi-dominant","Unknown",{"$nulls":4},"mutation 10, The Australian National University","m10Anu","MGI:5510772","Unknown",{"$nulls":28},"Abnormal kidney morphology:* abnormal kidney morphology ( J:199856 )• renal anomalies more prevalent in male than female mice• abnormal kidney position in 3 of 7 miceHydronephrosis ( J:199856 )• in 3 of 7 miceAbnormal kidney size ( J:199856 )• in 3 of 7 miceAbsent kidney ( J:199856 )• in 1 of 7 miceAbnormal ureter morphology:Double ureter ( J:199856 )• in 1 of 7 miceHydroureter ( J:199856 )• in 1 of 7 mice",null,"C3H/HeH * C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-08-21","Cryopreserved sperm",10,0,"Monash",null,"true",null,"Georgina","Caruana","Monash University","georgina.caruana@monash.edu",{"$nulls":3},"Vicki","Adams","vicki.adams@anu.edu.au","A2011/41",null,"No"]
[6964,"ENU20:015:a:B6:G3","ANU:ENU20:015:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",59,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4884,"NODlpr","NOD-Fas<lpr>",null,"Recessive","Fas (TNF receptor superfamily member 6)","Fas","Unknown","APO-1, CD95, TNFR6, Tnfrsf6","MGI:95484","lymphoproliferation","Fas<lpr>","MGI:1856334","19",{"$nulls":28},"NODlpr homozygotes have lymphadenopathy similar to the NOD.MRL(C3)-Faslpr/LtJ parental strain. This strain also has autoimmune characteristics similar to that seen on the MRL background (eg: immune complex glomerulonephritis).Unlike NOD/Lt mice, NOD.lpr mice do not develop diabetes. By 15 weeks of age lymphadenopathy is severe and mice need to be euthanased.","NODlpr heterozygotes are similar to NOD/LtJ (but there is a possibly reduced incidence of diabetes though not formerly tested).","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","15",null,"No","2009-09-28",null,0,0,null,null,"true",null,"Janette","Allison","St Vincent's Institute","jallison@svi.edu.au",{"$nulls":3},"Stacey","Fynch","sfynch@svi.edu.au","054/08","N/A","No"]
[5001,"aF11 aa278","FVB/N-Tg(Prm1-Pebp1)11Mkob/MarpApb",null,"Dominant",{"$nulls":25},"phosphatidylethanolamine binding protein 1","Protamine 1","low level expression",{"$nulls":11},"FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","0","0",null,"No","2010-02-22","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Gerard","Gibbs","ggibbs@unimelb.edu.au","N/A","N/A","No"]
[6967,"ENU20:021:b:B6:G3","ANU:ENU20:021:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",63,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[4903,null,"BALB/c-IL13<tm2Anjm>/MelbApb",null,"Recessive","interleukin 13","Il13","Nil","Il-13","MGI:96541","targeted mutation 2, Andrew NJ McKenzie","Il13<tm2Anjm>","MGI:1931804","11",{"$nulls":28},"Decreased T-helper 2 cell number.Abnormal T-helper 2 cell differentiaion.Increase immunoglobulin levels.Increase susceptibility to parasitic infection.Impaired eosinophil response to parasitic infection",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-10-09","Cryopreserved sperm",150,0,null,null,"false",null,"Neil","O'Brien-Simpson","The University of Melbourne","neil.obs@unimelb.edu.au",{"$nulls":3},"Jenny","Davis","davisja@unimelb.edu.au","N/A","N/A","No"]
[4894,"Ifngr1<441F>","C57BL/6-Ifngr1<tm1.1Rost>/Apb",null,"Recessive","interferon gamma receptor 1","Ifngr1","Normal","CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar","MGI:107655","interferon gamma receptor 1; targeted mutation 1.1, Robyn Starr","Ifngr1<tm1.1Rost>","MGI:4361521","10",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Homozygous Ifngr1<441F> mice were born in the expected Mendelian ratios and showed no signs of illness or obvious pathological abnormalities to at least 6 mo of age (data not shown). Similarly, the cellularity of lymphoid organs and activation state of lymphocytes was comparable to that of wt mice. the IFNGR1 Y441F mutation had significant effects on IFN-γ sensitivity and tumor resistance in vivo. We have shown improved anti-metastatic activity of GalCer in Ifngr1441F mice, and further that these mice have a subtle but significantly increased innate resistance to tumor formation.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-10-09","Cryopreserved sperm",100,0,null,null,"false",null,"Robyn","Starr","St Vincent's Institute","robynstarr9@gmail.com",{"$nulls":3},"Robyn","Starr","robynstarr9@gmail.com","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[69,"Sweaty","C57BL/6JStdAnu-Scd2<swty>/AnuApb","C57BL/6JStdAnu-Scd2<swty>/AnuApb","Recessive","stearoyl-Coenzyme A desaturase 2","Scd2","Unknown","Scd-2","MGI:98240","stearoyl-Coenzyme A desaturase 2; sweaty","Scd2<swty>","MGI:4888575","19","ENSMUSG00000025203","ENSMUST00000026221","Scd2-201","330","1042","C to T","ENSMUSE00000148829","3","109","Serine to Serine",{"$nulls":4},"CTCTTCGCGTATTTGTACTATGTAATCAGCGCCCTGGGCATCACAGCCGGGGCTCATCGCC","Unknown",{"$nulls":12},"Sweaty/oily thin coat; hyperplasia of sebacious glands, periocular inflammation, homozygote females breed poorly, males OK",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"G15","Het x Het","No","2006-02-06","Cryopreserved sperm",25,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[4910,"MommeR1","FVB-Foxo3<MommeR1>/Apb",null,"Recessive","forkhead box O3","Foxo3","Unknown","Fkhr2, FKHRL1, Foxo3a","MGI:1890081","modifier of murine metastable epialleles, R1","Foxo3<MommeR1>",null,"10",{"$nulls":15},"Yes","Green Fluorescent Protein","human alpha-globin promoter and enhancer region",{"$nulls":10},"Percentage of cells expressing the Line3 GFP transgene is decreased (enhancer of variegation).",null,"FVB/NJ","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Poor",null,null,"MommeD5<+/->;Tg(α-Globin-GFP)3EWh<tg/tg> x Tg(α-Globin-GFP)3EWh<tg/tg>","No","2009-10-09","Cryopreserved sperm",120,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whitelaw","emma.whitelaw@qimr.edu.au","N/A","N/A","No"]
[189,"M72-IRES-tau:GFP","Olfr160<tm6Mom>",null,"Dominant","olfactory receptor 160","Olfr160","Unknown","GA_x6K02T2PVTD-31389446-31388517, M72, MOR171-3, MOR171-3","MGI:1931271","targeted mutation 6, Peter Mombaerts","Olfr160<tm6Mom>","MGI:3692202","9",{"$nulls":15},"No",{"$nulls":12},"M72 odorant receptor neruons express GFP",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Brian","Key","The University of Queensland","brian.key@uq.edu.au",{"$nulls":3},"Brian","Key","brian.key@uq.edu.au","N/A","N/A","No"]
[192,"CD26 -/-","C57BL/6-Dpp<tm1Nwa>",null,"Recessive","dipeptidylpeptidase 4","Dpp4","Nil","Cd26, Dpp-4, THAM","MGI:94919","targeted mutation 1, Nicolai Wagtmann","Dpp4<tm1Nwa>","MGI:2150161","2",{"$nulls":15},"Yes",{"$nulls":12},"Reduced type II diabetes symptoms in diabetes models. Reduced insulin resistance when fed high fat diet.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Mark","Gorrell","Centenary Institute","m.Gorrell@centenary.usyd.edu.au",{"$nulls":3},"Mark","Gorrell","m.Gorrell@centenary.usyd.edu.au","N/A","N/A","No"]
[4928,"Jaffa","DBA1-Acan<tm2Afos>",null,"Recessive","aggrecan","Acan","Normal","Agc1, Cspg1","MGI:99602","targeted mutation 2, Amanda J Fosang","Acan<tm2Afos>","MGI:3713763","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice are phenotypically normal. Mice show part protection against aggrecanolysis and cartilage erosion in models of experimentally induced arthritis.",null,"DBA1","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-11-12",null,0,0,null,null,"true",null,"Amanda","Fosang","Murdoch Childrens Research Institute","amanda.fosang@mcri.edu.au",{"$nulls":3},"Amanda","Fosang","amanda.fosang@mcri.edu.au","N/A","N/A","No"]
[2372,null,"ENU8B6:061",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th2 polarized IgG1 antibody response to chicken gammaglobulin (CGG). ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",10,0,null,null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[6972,"ENU20:027:a:B6:G3","ANU:ENU20:027:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",27,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[3437,"common beta chain KO","C57BL/6-Csf2rb<tm1Cgb>/Wehi",null,"Recessive","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, C Glenn Begley","Csf2rb<tm1Cgb>","MGI:2181245","15",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16",null,0,0,null,"WEHI #335","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6646,"HOM.NOD.FADD51","NOD-Tg(RIP2-dnFADD)51Wehi/WehiStvApb",null,"Dominant",{"$nulls":25},"human dominant negative FADD","rat insulin promoter 2 (RIP)",{"$nulls":10},"NOD.FADD.51 homozygous mice have reduced incidence of diabetes compared to NOD/Lt mice. They are healthy and breed well.","Mice have a slightly reduced incidence of diabetes when compared to NOD/Lt mice","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10+","20+","Sister x Brother (hom x hom)","No","2011-11-15","Cryopreserved sperm",50,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Stacey","Fynch","sfynch@svi.edu.au","016/11","IBC#124 NLRD# 1995/2006","Yes"]
[287,"Tune","BALB/c-Il4<tm2Nnt>/AnuApb",null,"Recessive","interleukin 4","Il4","Unknown","IgG1, Il-4","MGI:96556","targeted mutation 2, Nancy Noben-Trauth","Il4<tm2Nnt>","MGI:1857195","11",{"$nulls":15},"No",{"$nulls":12},"abnormal dendritic cell differentiation:numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirdsdecreased IgE level:reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controlsdecreased IgG1 level:reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controlsabnormal dendritic cell antigen presentation:memory CD4 T cells activated by mutant DCs from inflamed lungs secrete low levels of Th2 cytokinesincreased interferon-gamma secretion:T cells from mice sensitized and challenged with OVA produce more IFN-gamma than controlsdecreased interleukin-13 secretion:lymphocytes from mice sensitized and challenged with OVA produce less IL-13 than controlsdecreased interleukin-5 secretion:lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controlsdecreased susceptibility to autoimmune disorder:mice fail to develop blood eosinophilia after being sensitized and challenged with OVA peptideairway hyperresponsiveness still occurs in these mice though less mucosal cells are found in the inflamed airwayhematopoietic systemabnormal dendritic cell differentiation:numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03","Cryopreserved sperm",100,0,"ANU","057","false",null,"Paul","Foster","The University of Newcastle","paul.Foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[5567,"ENU14Ch:048b","C57BL/6JAnu-Prkdc<m1Anu>/AnuApb","C57BL/6JAnu-Prkdc<m1Anu>/AnuApb","Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; mutation 1, The Australian National University","Prkdc<m1Anu>","MGI:5563438","16","ENSMUSG00000022672","ENSMUST00000023352","prkdc-201",{"$nulls":7},"15714375","34",null,null,"GTTTCTCTCATGTTATATCACCATCTCAGGTAACTATGATCAGTTTGTTTTAACATATCT",{"$nulls":13},"Decreased % of T and B cells","Decreased % of T and B cells","C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","4-6","5","Sib x sib","No","2011-08-24","Cryopreserved sperm",46,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","Anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[7073,"B6-ASCIZ-Nkx2.1-eYFP","C57BL/6-Atmin<tm1Jhh> Gt(ROSA)26Sor<tm(EYFP)Cos> Tg(Nkx2.1-cre)2Sand/J",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":58},"Sabine","Jurado","sjurado@svi.edu.au","GBNML304","069"]
[6771,"Cryo expt","ENU23B6:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Normal",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-12-20","Cryopreserved sperm",97,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","A2011/025","N/A","No"]
[7680,"ENU7PMH:130:RagKO ; Krusty:Rag1 KO","B6.Cg-Ndfip1<kru> Rag1<tm1Mom>/AnuApb",null,"Recessive","Nedd4 family interacting protein 1","Ndfip1",null,"0610010M22Rik","MGI:1929601","krusty","Ndfip1<kru>",null,"18","ENSMUSG00000024425","ENSMUST00000025293","Ndfip1-201",{"$nulls":7},"38612084","5",null,null,"TCTCTAATTAAGTGGATCCTTATTGTCAGGGTAAGTTGCATAGCAGAGAACAGATTGTGA",{"$nulls":13},"Autoimmune disease",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-05-13","Cryopreserved sperm",30,0,"ANU",null,"false",null,"Matthew","Cook","The Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Stephen","Daley","stephen.daley@anu.edu.au","N/A",null,"No"]
[7680,"ENU7PMH:130:RagKO ; Krusty:Rag1 KO","B6.Cg-Ndfip1<kru> Rag1<tm1Mom>/AnuApb",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":58},"Stephen","Daley","stephen.daley@anu.edu.au","N/A"]
[4476,null,"C.B6-TLR2<tm1Aki> TLR4<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 4","Tlr4","Unknown","lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; targeted mutation 1, Shizuo Akira ","Tlr4<tm1Aki>","MGI:1860885","4",{"$nulls":58},"Alistair","Reid","Alistair.reid@anu.edu.au","A.BS.01.09","N/A"]
[4465,null,"C57BL/6-IL5<tm1Kopf> Eotaxin<tm1Mer>/AnuApb",null,"Recessive","chemokine (C-C motif) ligand 11","Ccl11","Unknown","eotaxin, Scya11","MGI:103576","targeted mutation 1, Marc E Rothenberg","Ccl11<tm1Mer>","MGI:2384435","11",{"$nulls":61},"N/A","N/A"]
[6396,"PTPcnLPRHLtg","B6.Cg-Fas<lpr> Igh<tm1Rbr> Pepc<b> Ptprc<a> Tg(IgkHyHEL10)1Rbr>/Ausb",null,"Dominant","peptidase C","Pepc","Normal","Dip-1, Pep-3, Pep3","MGI:97541","peptidase C; b variant","Pepc<b>","MGI:4819861","Unknown",{"$nulls":58},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A"]
[343,"B7C kk","B10.Cg-Tg(SERPINC1-CD86)/Apb",null,"Dominant",{"$nulls":25},"murine CD86","human anti-thrombin III (SERPINC1) + regulatory intronic sequences of MHC class II","low on 15% of hepatocytes",{"$nulls":9},"Express CD86 on 15% of hepatocytes. Expression elsewhere has not been reported.","Express CD86 on 15% of hepatocytes. Expression elsewhere has not been reported.","C57BL/10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","15","B7Ckk X B7Ckk","No","2006-09-22","Cryopreserved sperm",30,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.usyd.edu.au",{"$nulls":3},"Patrick","Bertolino","p.bertolino@centenary.usyd.edu.au","N/A","N/A","No"]
[1507,null,"C57BL/6-IL12b<tm1Jm> IL18<tm1Aki>/Apb",null,"Recessive","interleukin 18","Il18","Nil","Igif, Il-18","MGI:107936","targeted mutation 1, Shizuo Akira","Il18<tm1Aki>","MGI:2136769","9",{"$nulls":58},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A"]
[4992,"c-cbl KO","STOCK H2<k2> Cbl<tm1Ddlb>/AnuApb ",null,"Recessive","Casitas B-lineage lymphoma","Cbl","Nil","c-Cbl, cbl, Cbl-2","MGI:88279","targeted mutation 1, David D L Bowtell","Cbl<tm1Ddlb>","MGI:2180578","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.Abnormal spleen red pulp morphology- expandedenlarged spleen. Spleen is enlarged about 1.2- to 2-fold compared to wild type mice due to expansion of the red pulpspleen hyperplasia.Increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.Abnormal adipocyte morphology- adipocyte volume is reduced by about 64% compared to wild type mice.Decreased adipose tissue amount- despite increased caloric intake, a 40-50% decrease in the size of the adipose tissue depots (including both white and brown fat) is seenthis phenotype is more pronounced in males than in females.Increased lean body mass- balances the decrease in adipose tissue resulting in no significant difference in total body weight.Polyphagia.Hyperactivity- about a 4-fold increase in ambulatory activity is seen, especially during the dark phase.Increased body temperature- rectal temperature is increased by 1 degree C independent of time of day or if the mice are fed or fasted overnight. However, circulating levels of triiodothyronine or thyroxine are similar to wild type in both the fed and fasted states.Decreased circulating leptin level- leptin levels are decreased by 66%; however adiponectin levels are similar to wild type.Abnormal gas homeostasis- increased oxygen consumption:whole body oxygen consumption corrected for the difference in lean mass is increased by 22% compared to wild type mice.Abnormal respiratory quotient- reduced respiratory quotientAbnormal glucose homeostasis- decreased circulating insulin level, after an overnight fast insulin levels are decreased relative to wild type but glucose levels are similar to wild type.Improved glucose tolerance- improved glucose tolerance despite decreased insulin levels throughout the test.Increased insulin sensitivity.Abnormal lipid homeostasis- decreased circulating free fatty acid level.Decreased triglyceride level- triglyceride levels in the liver are decreased but those in the quadriceps muscle are similar to wild type muscleAbnormal muscle physiology- glucose clearance in to glycogen is increased in the soleus and extensor digitorum longus muscles but not in the liver.Abnormal muscle cell glucose uptake- glucose uptake into skeletal muscle is increased about 2-fold; however glucose uptake into white and brown adipose tissue is not different from wild type. Basal and insulin-stimulated glucose uptake are increased in soleus muscle explants by 65% and 30%, respectively; however, glucose uptake is not increased in fat explants basal, but not insulin-stimulated, glucose uptake is increased by 30% in extensor digitorum longus muscle explantscellular.Abnormal mitochondrial morphology- a 2-fold increase in the average size of subsarcolemmal mitochondria is seen; however, no increase in mitochondrial area or cristae density is seen in the subsarcolemmal region.Spleen hyperplasia- increase in the number of megakaryocytes, megakaryoblasts, and myelocytes but no increase in the number of lymphocytes is seen in the spleen.",null,"129/1SV x C57BL/6 x C57BL/10.BR-H2<k2>","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",45,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lina","Tze","lina.tze@anu.edu.au","N/A","N/A","No"]
[1524,null,"C.Cg-Myd88<tm1Aki> Tg(CD2-IL5)5C2Ldt/Apb","C.Cg-Myd88<tm1Aki> Tg(CD2-IL5)5C2Ldt/Apb","Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","targeted mutation 1, Shizuo Akira","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":15},"Yes","transgene insertion 5C2, Lindsay A Dent ","The dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Provide a source of Myd88 deficient eosinophils",null,"BALB/c","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2007-07-05","Cryopreserved sperm",80,0,"ANU","075","false",null,"Simon","Phipps","The University of Newcastle","Simon.Phipps@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[5028,null,"Ym2 Tg(+/+) Balb/c X CC10/rtTA Tg(+/-) Balb/c",null,"Dominant",{"$nulls":39},"6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",60,0,null,"ABS #160","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6975,"ENU20:028:b:B6:G3","ANU:ENU20:028:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",45,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7535,"P14","B6;D2-tg(TcrLMCV)327Sdz/JDvsJWehiAusb","B6;D2-tg(TcrLMCV)327Sdz/JDvsJWehi","Dominant",{"$nulls":25},"transgene insertion 327, Birgit Ledermann",null,"10-20",{"$nulls":11},"(C57BL/6 x DBA/2)F2","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-12-12",null,0,0,"ABR - Moss Vale","3575","true",null,"Stuart","Tangye","Garvan Institute","s.tangye@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[2354,"Azharrudin","B6.129S2-Cd28<tm1Mak> Tg(TcraTcrb)1100Mjb",null,"Recessive",null,null,"Unknown",{"$nulls":3},"Tg(TcraTcrb)1100Mjb","MGI:3054907","Unknown",{"$nulls":58},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A"]
[4777,"CCR +/+","B6.129-Ccr(WT)",null,"Dominant",{"$nulls":37},"Normal.Control for experiments with Ccr5 knockouts.  A control strain in which the CCR gene cluster is derived from the 129/Ola strain was developed by crossing wild-type F1 progeny of 129/Ola × C57BL/6J matings (40). A BglII restriction fragment length polymorphism was found that distinguishes the CCR5 allele in 129/Ola and C57BL/6J; a probe made from a 1.5-kb XbaI fragment located about 1.8 kb upstream of the CCR5 coding exon detects a 3.3-kb BglII fragment in 129/Ola and a 3.6-kb BglII fragment in C57BL/6J genomic DNA.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",150,0,null,"ABS #130","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","A.BS.01.09","N/A","No"]
[65,null,"Rockstar",null,"Recessive",null,null,"Unknown",{"$nulls":5},"2",{"$nulls":15},"Yes",{"$nulls":12},"Microphthalmia or no eyes, weepy eyes; clumpy fur, chocolate coat and some hair loss in older mice",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",35,0,null,null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[7392,"B6.Nramp","B6.129-Slc11a1<r>/Apb",null,"Dominant","solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1","Slc11a1","Normal","Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Lsh, Nramp, Nramp1","MGI:1345275","solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; host resistance (Bcg/Ity/Lsh)","Slc11a1<r>","MGI:1857756","1",{"$nulls":28},"Decreased susceptibility to bacterial infection:the mutation results in Gly at position 105 substitution within predicted transmembrane domain 2 of Nramp.This results in resistance to infection with Mycobacteria, Salmonella and Leishmania","Similar to hom state but resistance is intermediate.","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent","13",null,null,"Yes","2013-08-06","Cryopreserved sperm",50,0,null,null,"false",null,"Odilia","Wijburg","The University of Melbourne","odilia@unimelb.edu.au",{"$nulls":3},"David","Taylor","d.taylor@unimelb.edu.au","1212586",null,"No"]
[4532,"Cat-1-eGFP","C57BL/6-Tg(Tie2-Slc7a1/eGFP)/Apb",null,"X-linked",{"$nulls":25},"solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 fused to eGFP (Atrc-1, Atrc1, Cat1, mCAT-1, Rec-1, Rev-1)","endothelial-specific receptor tyrosine kinase (Tek, Tie2)",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm",95,0,null,null,"false",null,"David","Kaye","Baker IDI Heart and Diabetes Institute","david.kaye@bakeridi.edu.au",{"$nulls":3},"David","Kaye","david.kaye@bakeridi.edu.au","N/A","N/A","No"]
[7728,"ENU32:G2","ANU:ENU32:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2014-08-26","Cryopreserved sperm",3631,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[5032,null,"Control",null,"Dominant",{"$nulls":39},"1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",940,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au","Building 117 Garran Rd Acton","Canberra","ACT","Stuart","Read","stuart.read@anu.edu.au","N/A","N/A","No"]
[5026,"Bertolino","Bertolino",null,"Recessive",{"$nulls":39},"1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",10,0,null,null,"true",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.usyd.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5018,"BALB/cLac I","BALB/c.FVB/n-Lac I (USA) Tg1",null,"Dominant",{"$nulls":39},"10","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",150,0,null,"xxx","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5023,"Waugh","BALB/c-Homo Rosa EGFP<tg1>",null,"Dominant",{"$nulls":39},"9","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",120,0,null,"ABS #050","true",null,"Klaus","Matthaei","The Australian National University","Klaus.Matthaei@anu.edu.au","Building 131, Garran Road","Acton","ACT",{"$nulls":3},"N/A","N/A","No"]
[220,"Z/AP","Tg(CAG-Bgeo/ALPP)1Lbe",null,"Dominant",{"$nulls":25},"transgene insertion 1, Corrinne Lobe","CMV enhancer/chicken beta-actin promoter",{"$nulls":10},"Prenatal lethality","No information is available","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25",null,0,0,null,null,"true",null,"Christine","Biben","Walter and Eliza Hall Institute of Medical Research","biben@wehi.edu.au",{"$nulls":3},"Christine","Biben","biben@wehi.edu.au","N/A","N/A","No"]
[4870,"Bc.HTF1.Tg","BALB/c-Tg(H2-K-huFUT1)1/Apb",null,"Dominant",{"$nulls":25},"human fucosyltransferase 1","H2-K<b>","All blood/tissue samples express human fucosyltransferase 1",{"$nulls":9},"Attempts to breed homozygous animals failed. Unknown if homozygous transgene expression is embryonic lethal.","Normal.All blood/tissue samples express human fucosyltransferase.","BALB/c","No","No","Yes","No","No","Yes","No","Unknown","15",null,null,"No","2009-09-28","Cryopreserved sperm",80,0,"St V",null,"false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML 20","94","No"]
[7729,null,"ENU20:016a",null,"Recessive","caspase recruitment domain family, member 1","Card11","Unknown","0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1","MGI:1916978",{"$nulls":3},"5",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-08-27","Cryopreserved sperm",20,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A",null,"No"]
[6978,"ENU20:033:a:B6:G3","ANU:ENU20:033:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",20,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6218,"B6del478","C57BL/6-Fasl<tm1.1Ast>",null,"Dominant","Fas ligand (TNF superfamily, member 6)","Fasl","Normal","APT1LG1, CD178, CD95L, Fas-L, Tnfsf6","MGI:99255","Fas ligand (TNF superfamily, member 6); targeted mutation 1.1, Andreas Strasser","Fasl<tm1.1Ast>","MGI:4366050","1",{"$nulls":28},"Premature death:*Compared with wild-type mice and Fasl<gld> homozygotes.Immune system phenotype:*Mice mount a normal immune response to influenza.      Enlarged spleen      Increased circulating tumor necrosis factor level      *At 12 to 20 weeks.      Enlarged lymph nodes      Increased immunoglobulin level         Increased IgA level         Increased IgE level         Increased IgG level            Increased IgG1 level            Increased IgG2a level            Increased IgG2b level         Increased IgM level      Defective cytotoxic T cell cytolysis:      *T cells are less efficient than wild-type cells at killing CH1 cells.      Increased susceptibility to systemic lupus erythematosus      *62% of terminally ill mice exhibit systemic lupus erythematosus-like (SLE) autoimmune disease with cellular crescents, protein casts, and compliment in renal glomeruli unlike wild-type mice.      *Mice develop more severe SLE-like disease than Fasl<gld> homozygotes.      *By 57 weeks, 50% of mice develop fatal SLE-like autoimmune kidney disease compared with 15% of Faslgld homozygotes.      Increased anti-nuclear antigen antibody level:      *Higher than in wild-type mice and Fasl<gld> homozygotes.         Increased anti-double stranded DNA antibody level:         *Higher than in wild-type mice and Fasl<gld> homozygotes.      Glomerulonephritis      *Mice develop SLE-like glomerulonephritis unlike wild-type mice and more frequently than Faslgld homozygotes.      Dermatitis:      *30% of mice develop severe dermatitis with lesions on the ears and necks unlike wild-type mice.Increased histiocytic sarcoma incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.Increased liver tumor incidence:*By 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs.Increased circulating tumor necrosis factor level:*At 12 to 20 weeks.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1532","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6822,"MTf knockout","B6.129X1-Mfi2<tm1Drrn>/Apb","B6.129X1-Mfi2<tm1Drrn>","Recessive","antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5","Mfi2","Nil","CD228, melanotransferrin, MTf","MGI:1353421","antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; targeted mutation 1, Des R Richardson","Mfi2<tm1Drrn>","MGI:3691276","16",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"20+",null,"No","2012-02-24","Cryopreserved sperm",50,0,null,null,"false",null,"Des","Richardson","The University of Sydney","d.richardson@sydney.edu.au",{"$nulls":3},"Chai","Lim","edwin.lim@sydney.edu.au","USYD K20/3-2010/3/5251","N/A","No"]
[6992,"ENU20:055:a:B6:G3","ANU:ENU20:055:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6981,"ENU20:036:a:B6:G3","ANU:ENU20:036:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6995,"ENU21:001:a:B6:G3","ANU:ENU21:001:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6993,"ENU20:058:b:B6:G3","ANU:ENU20:058:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-05","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7732,"A/J - Joey-RSA","A/J.B6-Rbm5<sda>/MarpApb",null,"Recessive","RNA binding motif protein 5","Rbm5","Unknown",null,"MGI:1933204","Joey",null,null,"9","ENSMUSG00000032580","ENSMUST00000035199","Rbm5-201","788","940","G to C","ENSMUSE00000251397","10","63","Arginine to Proline",{"$nulls":4},"CTATGCTTCCTTAGCTGTCAATAACATTCGCCTCATAAAAGACAAACAGACACAACAGAAC","Yes",{"$nulls":12},"Embryonic lethal","Round spermatid arrest.","A/JMarp","No","No","Yes","No","No","Yes","No","Unknown","8",null,null,"No","2014-09-05","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Duangporn","Jamsai","Monash University","duangporn.jamsai@monash.edu",{"$nulls":6},"N/A",null,"No"]
[7538,"Rag2","B6N.129S6-Rag2<tm1Fwa>/FwaAusb","B6N.129S6-Rag2<tm1Fwa>/FwaAusb","Recessive","recombination activating gene 2","Rag2","Normal","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2",{"$nulls":28},"Homozygous mice exhibit total inability to initiate V(D)J rearrangement and fail to generate mature T or B lymphocytes.",null,"C57BL/6NTac","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","12",null,null,"No","2013-12-13",null,0,0,"ABR - Moss Vale","3593","true",null,"John","Mattick","Garvan Institute","director@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[5073,"Syrup","FVB/N-MommeD7",null,"Semi-dominant","modifier of murine metastable epialleles, D7","MommeD7","Unknown",null,"MGI:3821590","modifier of murine metastable epialleles, D7","MommeD7","MGI:3821597","7",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes","Green Fluorescent Protein (GFP)","human alpha-globin promoter and enhancer region",{"$nulls":10},"Mice homozygous for a mutation at this locus display semidominant lethality and are never seen at weaning.Postnatal lethality: * semidominant homozygous lethal * never seen at weaning * death occurs within a few days of birthPallor: about 1/4 of mice are pale in color at E17.5Decreased erythrocyte cell number: at E17.5","Percentage of cells expressing the GFP transgene (Line3) is increased (suppressor of variegation). Reticulocytosis: a 3 fold increase in the number of circulating reticulocytes.Enlarged spleen: severe","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD7<+/->;Tg(Hba1-Gfp)3Ew<tg/tg> x Tg(Hba1-Gfp)3Ew<tg/tg>","No","2010-03-25","Cryopreserved sperm",30,0,null,null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Trevor","Epp","trevor.epp@qimr.edu.au","N/A","N/A","No"]
[6930,"ENU21:G1","ANU:ENU21:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-02","Cryopreserved sperm",744,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6996,"ENU21:004:b:B6:G3","ANU:ENU21:004:b:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",27,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6997,"ENU21:007:a:B6:G3","ANU:ENU21:007:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6999,"ENU21:009:a:B6:G3","ANU:ENU21:009:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7543,"ENU28:008:Ndst3","C57BL/6NCrlAnu-Ndst3<m1Anu>/AnuApb","C57BL/6NCrlAnu-Ndst3<m1Anu>/Apb","Recessive","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3","Ndst3",null,"4921531K01Rik, 4930511P15Rik","MGI:1932544","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; mutation 1, The Australian National University","Ndst3<m1Anu>","MGI:5571271","3","ENSMUSG00000027977","ENSMUST00000154668","Ndst3-001","2351","2620","T to C","ENSMUSE00001216254","12","784","Glutamine to Arginine",{"$nulls":4},"TACCCCTGCGACAGTGATGGATGAAGTCCAGAAGTTTCTAGGAGTCTCACCTCATTATAAT",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G3",null,"No","2013-12-13","Cryopreserved sperm",66,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[5821,"HB9-EGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5823,"HDAC Short",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[4107,null,"KRN:069",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",20,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[7003,"ENU21:017:a:B6:G3","ANU:ENU21:017:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",38,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7005,"ENU21:020:a:B6:G3","ANU:ENU21:020:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",30,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[6418,"A20","B6.Cg-Tnfaip3<tm1Ama>/AnuAusb?",null,"Recessive","tumor necrosis factor, alpha-induced protein 3","Tnfaip3","Nil","A20, Tnfip3, zinc finger protein A20","MGI:1196377","tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma","Tnfaip3<tm1Ama>","MGI:3055173","10",{"$nulls":28},"Abnormal cytokine secretion:*Bone marrow derived macrophages produce more TNF, IL-6, and nitric oxide in response to LPS treatment compared to wild-type macrophages.Abnormal inflammatory response:*The absolute number and percentage of myeloid cells is increased in multiple tissues.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2808","true",null,"Shane","Grey","Garvan Institute","s.grey@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[4917,"eed3354","B6.C-Eed<17Rn5-3354SB>/WehiApb",null,"Recessive","embryonic ectoderm development","Eed","Unknown","l(7)5Rn, l7Rn5","MGI:95286","lethal, Chr 7, Rinchik 5, 3354SB","Eed<17Rn5-3354SB>","MGI:1856856","7",{"$nulls":28},"Gastrulation defects.The amnion and chorion are formed.The head process and notochord are absent and somites fail to organise.Unlike eed deletion mutants, Eed<3354SB> embryos develop characteristic folds in the anterior embryonic ectoderm.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2009-10-16","Cryopreserved sperm",100,0,"WEHI",null,"false",null,"Doug","Hilton","Walter and Eliza Hall Institute of Medical Research","hilton@wehi.edu.au",{"$nulls":3},"Marnie","Blewitt","blewitt@wehi.edu.au","N/A","N/A","No"]
[6652,"NOD.HJ12D-18","NOD/Lt-Tg(IL12B)HJ18Gem/Arc",null,"Dominant",{"$nulls":25},"human interleukin 12b",{"$nulls":11},"Mice express human interleukin 12B",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"Hom x Hom","No","2011-11-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",{"$nulls":5},"N/A","N/A","No"]
[7010,"ENU21:027:a:B6:G3","ANU:ENU21:027:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[8163,"Nlrp3 KO","B6.129S6-Nlrp3<tm1Bhk>/J",null,"Recessive","NLR family, pyrin domain containing 3","Nlrp3",null,"Cias1, cryopyrin, Mmig1, NALP3, Pypaf1","MGI:2653833","NLR family, pyrin domain containing 3; targeted mutation 1, Beverly H Koller","Nlrp3<tm1Bhk>","MGI:5465108","11",{"$nulls":28},"Immune system phenotype:N \t• macrophages exhibit normal response to anthrax lethal toxin• bone marrow derived macrophages are not sensitive to the challenge by the bacteria peptidoglycan motif of muramyl dipeptide (MDP).Decreased interleukin-1 beta secretion:\t• in macrophages exposed to titanium oxide with or without muramyl dipeptide or peptidoglycan• in macrophages exposed to L18-muramyl dipeptideDecreased lactate dehydrogenase level:\t• in the bronchoalveolar lavage (BAL) fluids",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-01-23",null,0,0,"ANU",null,"true",null,"Si Ming","Man","The Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[8246,"Aim2 KO","C57BL/6N-Aim2<tm1.1Vmd>/VmdAnu",null,"Recessive","absent in melanoma 2","Aim2","Nil","Ifi210, LOC383619","MGI:2686159","absent in melanoma 2; targeted mutation 1.1, Vishva M Dixit","Aim2<tm1.1Vmd>","MGI:5428935","1",{"$nulls":28},"Abnormal macrophage physiology:• improved cell viability following transfection with poly(dA:dT) or pcDNA3• improved bone marrow derived macrophage viability following infection with F. tularensisAbnormal cytokine secretion.Increased interferon-beta secretion:• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3Decreased interleukin-1 beta secretion:• in LPS-primed bone marrow derived macrophages or peritoneal macrophages stimulated by dsDNA• bone marrow derived macrophages do not secrete IL1B in response to F. tularensisDecreased interleukin-18 secretion:• in LPS-primed bone marrow derived macrophages stimulated by dsDNAIncreased tumor necrosis factor secretion:• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3Increased susceptibility to bacterial infection:• fail to control F. tularensis infection",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-04-20",null,0,0,"ANU",null,"true",null,"Si Ming","Man","The Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[5329,null,"129T2/SvK-Ryk<tm1Stac>/Apb",null,"Recessive","Receptor-like tyrosine kinase","Ryk","Nil","ERK-3, Vik","MGI:101766","receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker","Ryk<tm1Stac>","MGI:2667542","9",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes die on the day of birth. Approx. 90% of E18.5 embryos have heart defects, the probable cause of neonatal death. They also have a cleft palate, craniofacial defects, shortened limbs and body axis, inner ear defects and abnormal corpus callosum (brain).Abnormal gait: mice surviving to adulthood dragged their hindlimbs.Short mandible.Abnormal maxilla morphology: in conjunction with shortened nasal bone, resulting in flattened midface.Abnormal neurocranium morphology: slightly smaller and rounder than that of wild-type or heterozygous mutant mice.Short nasal bone: shortened nasal bone, resulting in flattened midface.Cleft secondary palate: * cleft secondary palate observed in 88% of mice * consequence of abnormally high positioning and enlargement of the tongue.Increased tongue size: enlargement observed around E14, resulting in the disruption of the development of the palatal shelf.Short snout.Microcephaly: exhibited by mice that survived to adulthood.Cachexia.Postnatal growth retardation: growth was severely impaired in mice surviving past the first day of life.Cyanosis: mice were largely unable to suckle, became dehydrated, cyanotic, and exhibited gasping respirations.Short ulna: reduced in length.Abnormal hindlimb morphology: hindlimbs were splayed laterally.Short fibula.Short limbs: 18% to 25% reduction in the length of the long bones.Microphthalmia: bilateral microphthalmia was observed in mice that survived to adulthood.",null,"129T2/Sv/K","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2010-11-19","Cryopreserved sperm",50,0,"Ludwig",null,"false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria","Steven","Stacker","steven.stacker@petermac.org","003/09","040/2001 & 304","No"]
[7014,"ENU21:034:a:B6:G3","ANU:ENU21:034:a:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2012-07-06","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[219,null,"C57BL/6-Gt(ROSA)26Sor/WehiAnuApb",null,"Dominant",{"$nulls":25},"gene trap ROSA 26, Philippe Soriano","unknown endogenous",{"$nulls":10},"Viable and fertile. Mice carrying this mutation are considered to be reporter strains, with successful Cre excision indicated by beta-gal expression in Cre-expressing tissues.  There is no phenotype and mice appear normal.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25","Cryopreserved sperm",43,0,"ANU",null,"false",null,"David","Tscharke","The Australian National University","david.tscharke@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5408,"Gp130Y757f / Stat3+/- / Stat1-/-","STOCK Il6st<tm1Ern> Stat3<tm1Aki> Stat1<tm1Rds>/LudApb",null,"Recessive","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Unknown","C57BL/6 x 129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-02-03","Cryopreserved sperm",50,0,"Ludwig","BJ-24","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"019/09","040/2001 & 304","No"]
[1752,"Hepsin KO","129-Hpn<tm1Qwu>/Wehi",null,"Semi-dominant","hepsin","Hpn","Nil",null,"MGI:1196620","targeted mutation 1, Qingyu Wu","Hpn<tm1Qwu>","MGI:3639336","7",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop normally and are viable and fertile.Mice are deaf.  Mice homozygous for a null mutation are hypothyroidic and develop profound hearing loss associated with structural changes in the tectorial membrane and a myelination defect affecting the compaction of spiral ganglion neurons.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-02",null,0,0,null,"WEHI #240","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hamish.scott@imvs.sa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[5393,"a33 b-neo/b-neo","C57BL/6-Gpa33<tm2Ern>/Apb",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,"A33 antigen","MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 2, Matthias Ernst","Gpa33<tm2Ern>",null,"1",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-01-24","Cryopreserved sperm",50,0,"Ludwig","ME-112","false",null,"Matthias","Ernst","Ludwig Institute for Cancer Research, Melbourne","matthias.ernst@ludwig.edu.au",{"$nulls":6},"029/10","040/2001 7304","No"]
[8480,"KRN TCR transgenic/B10.Br","B10.BR-Tg(TcraR28,TcrbR28)KRNDim/Apb",null,"Dominant",{"$nulls":25},"transgene insertion KRN, Diane Mathis",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-05-03","Cryopreserved sperm",40,0,null,null,"false",null,"Andrew","Cook","The University of Melbourne","adcook@unimelb.edu.au",{"$nulls":8},"No"]
[1737,"VavP-BCL2-69","C57BL/6-Tg(Vav-BCL2)1Jad/Wehi",null,"Dominant",{"$nulls":25},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":10},"Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,null,"WEHI #55, 1602","true",null,"Jerry","Adams","Walter and Eliza Hall Institute of Medical Research","adams@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1766,null,"GATA4 KO",null,"Recessive","GATA binding protein 4","Gata4","Unknown","Gata-4","MGI:95664",{"$nulls":3},"14",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.",null,"C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #329","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1788,"HRIpClg","B6.C-H2<bm1> Tg(Ins-CTLA4/IgFc)/Wehi",null,"Dominant",{"$nulls":25},"Mouse CTLA4 was fused to the Fc of mouse IgG2c","rat insulin promoter","High and Low clones",{"$nulls":9},"No Phenotype, except continue to excrete rotovirus longer than usual. No diabetes developes.  IMMUNOCOMPROMISED",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #555","true",null,"Andrew","Lew","Walter and Eliza Hall Institute of Medical Research","lew@wehi.edu",{"$nulls":6},"N/A","N/A","No"]
[1767,null,"CD3e chain knockout mice",null,"Recessive","CD3 antigen, epsilon polypeptide","Cd3e","Unknown","CD3, CD3epsilon, T3e","MGI:88332",{"$nulls":3},"9",{"$nulls":15},"Yes",{"$nulls":12},"No Mature T cells. No CD4+ or CD8+ cells in thymus or spleen.Arrested T cell development at double negative stage.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03",null,0,0,null,"WEHI #333","true",null,"Li","Wu","Walter and Eliza Hall Institute of Medical Research","wu@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1832,"ICSBP / Blimp-1 knockout","Un-Prdm1<tm1Nutt> Irf8<tm1>/Wehi",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","Blimp-1, Blimp1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":15},"Yes","Green fluorescent protein (GFP)",{"$nulls":11},"Blimp-1 homozygous mice die late gestation -  after fetal liver reconstitution are immunocompromised.ICSBP KO - Immune deficient leukaemia with age.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08",null,0,0,null,"WEHI #1093","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1822,"RelA knockout Bcl-2 transgenic","C57BL/6-Rela<tm1Bal> Tg(Vav-BCL2)1Jad/Wehi",null,"Recessive","v-rel reticuloendotheliosis viral oncogene homolog A (avian)","Rela","Nil","p65, p65 NF kappaB","MGI:103290","targeted mutation 1, David Baltimore","Rela<tm1Bal>","MGI:1857270","19",{"$nulls":15},"Yes","transgene insertion 1, Jerry M Adams","hemopoiesis-specific vav promoter",{"$nulls":10},"Strain may be partially immunocompromised, due to the P65 strain.  P65 homozygous knockouts are embryonic lethal at day 15 gestation",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #1016","true",null,"Steve","Gerondakis","Walter and Eliza Hall Institute of Medical Research","gerondakis@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1844,"Matriptase knockout","NIH Black Swiss-St14<tm1Bug>/Wehi",null,"Recessive","suppression of tumorigenicity 14 (colon carcinoma)","St14","Nil","Epithin, matriptase, MT-SP1, Prss14","MGI:1338881","targeted mutation 1, Thomas H Bugge","St14<tm1Bug>","MGI:2683707","9",{"$nulls":15},"No",{"$nulls":12},"Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within 48hrs of birth.",null,"Black Swiss","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1247","true",null,"Hamish","Scott","Walter and Eliza Hall Institute of Medical Research","hamish.scott@imvs.sa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[1862,"B6.CD19Cre/PU.1","C57BL/6-Cd19<tm1(cre)Cgn> Sfpi1<tm1.2Nutt>/Wehi",null,"Recessive","SFFV proviral integration 1","Sfpi1","Unknown","Dis-1, PU.1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1","MGI:98282","SFFV proviral integration 1; targeted mutation 1.2, Stephen L Nutt","Sfpi1<tm1.2Nutt>","MGI:3578011","2",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop B cells leukemia after > 1/2 year. Only in 15% of all mice, only in aged mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #1090","true",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6448,"ST5?","B6.129S6-Stat5a/Stat5b<tm2.1Mam>/Ausb?",null,"Recessive","signal transducer and activator of transcription 5A","Stat5a","Nil","STAT5","MGI:103036","signal transducer and activator of transcription 5A; targeted mutation 2.1, Lothar Hennighausen","Stat5a/Stat5b<tm2.1Mam>","MGI:3055320","11",{"$nulls":28},"Partial perinatal lethality:*Most of the mice die perinatally.Premature death:*Approximately 1% of the mice reach weaning age, and die within the first 6 weeks after birth.Decreased body size:*Mice surviving to weaning age are smaller than their littermates.      Decreased body weight:        *Reduced body weight in survivor mice at the age of 4 weeks.Decreased total lung capacity:*Reduced lung capacity.Decreased B cell number:*No early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively).*Reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively).*Few mature B-lymphoid cells are present in the periphery.Decreased CD8-positive T cell number:*Reduction of CD8+ T cells (2.5-fold) in the thymus.*Reduction of CD8+ T cells (12-fold) in the lymph nodes.Absent gamma-delta T cells:*Absent CD4- CD8- gamma-delta TCR+ cells in the thymic cell suspension.Arrested B cell differentiation:*B-cell development is arrested at the pre-pro-B-cell stage in survivor mice and in fetal liver-derived cultures.*No pro-B, immature, and mature B cells in cultures derived from fetal livers.*No early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively).*Reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively).*Few mature B-lymphoid cells are present in the periphery.Small spleen:*Smaller spleen than that would be expected from the body size of the mice.Small thymus:*Smaller thymus than that would be expected from the body size and age of the mice.Small lymph nodes:*Smaller lymph nodes than that would be expected from the body size of the mice.Decreased tumor incidence:*No growth factor-independent colonies in cultured fetal livers and bone marrow cells transformed by Abelson oncogene or a murine stem-cell virus.*Abelson-transformed cells fail to induce leukemia in vivo.Anemia:*Severe anemia.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2347","true",null,"Jenny","Gunton","Garvan Institute","j.gunton@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[3403,"NP2 KO","B6.129-Nrp2<Gt(pMS-1)1Hmy/Wehi",null,"Recessive","neuropilin 2","Nrp2","Nil","1110048P06Rik, NP-2, NP2, Npn-2, Npn2","MGI:1100492","neuropilin 2; gene trap 1, Heather M Young","Nrp2<Gt(pMS-1)1Hmy>","MGI:3712239","1",{"$nulls":15},"No",{"$nulls":12},"Overall body size is reduced compared to wild-type. Increased perinatal lethality is observed compared to wild-type.",null,"129 x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13",null,0,0,null,"WEHI #72","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3412,"Conditional SOCS3 knockout","C57BL/6-Socs3<tm2Wsa>/Wehi",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Normal","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":15},"No",{"$nulls":12},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2008-07-14",null,0,0,null,"WEHI #121","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6666,"T286","C57BL6-Camk2a<tm2Sva>/Ausb",null,"Dominant","calcium/calmodulin-dependent protein kinase II alpha","Camk2a","Normal","alpha-CaMKII, CaMKII, mKIAA0968","MGI:88256","calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 2, Alcino Silva","Camk2a<tm2Sva>","MGI:2158733","18",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2117","true",null,"John","Rostas","Moss Vale","john.rostas@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7314,"Epo-R-CreERT2 R26eYFP ADAR1fl/fl","C57BL/6-Epor<tm2285(Cre/ESR1)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Adar<tm1.1Phs>/SviApb",null,"Dominant","adenosine deaminase, RNA-specific","Adar ","Nil","ADAR1, mZaADAR","MGI:1889575","adenosine deaminase, RNA-specific; targeted mutation 1.1, Peter H Seeburg","Adar<tm1.1Phs>","MGI:3828307","3",{"$nulls":28},"Epo-R-CreER is hmozygous lethal due to loss of endogenous Epo-R expression","normal, viable, fertile","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","generated on pure C57BL/6 so not backcrossed. Only maintained on C57",null,null,"No","2013-04-10","Cryopreserved sperm",40,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC168 SABC025","No"]
[3427,"GK5 transgenic","C57BL/6-Tg(TcraCD4,TcrbCD4)",null,"Dominant",{"$nulls":25},"Chimeric anti-mouse CD4 antibody","human cytomegalovirus immediate-early promoter",{"$nulls":10},"No peripheral CD4 cells",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-15",null,0,0,null,"WEHI #249","true",null,"Andrew","Lew","Walter and Eliza Hall Institute of Medical Research","lew@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3436,"relB KO (Line 272)","C57BL/6-Relb<Tg(H2-K1/GH1)106Bri>/Wehi",null,"Recessive","avian reticuloendotheliosis viral (v-rel) oncogene related B","Relb","Nil",null,"MGI:103289","avian reticuloendotheliosis viral (v-rel) oncogene related B; transgene insertion 106, Ralph L Brinster","Relb<Tg(H2-K1/GH1)106Bri>","MGI:2179544","7",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted and insertional null mutations exhibit inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, and epidermal hyperplasia. Runted, swollen abdomens. Scaly feet, ears and tails. Tight skin, hard to scruff.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16",null,0,0,null,"WEHI #332","true",null,"Li","Wu","Walter and Eliza Hall Institute of Medical Research","wu@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3470,"Taube nuss Genetrap","129-Taf8<Gt(pGT1.8geo)9Pgr>/Wehi",null,"Recessive","TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq","Taf8","Nil","Taf8, Tbn","MGI:1926879","gene trap 9, Peter Gruss","Taf8<Gt(pGT1.8geo)9Pgr>","MGI:3033758","17",{"$nulls":15},"Yes",{"$nulls":12},"Embryos homozygous for a gene trap mutation die at E4.0 and exhibit apoptosis of inner mass cells.","Normal","129/SvPas","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-22",null,0,0,null,"WEHI #472","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","voss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3480,"Bm1.RIP-CD5LIg","C57BL/6-Tg(ins2-CD5lIg)/Wehi",null,"Dominant",{"$nulls":25},"CD5 leader sequence (control=CD5LIg) fused to the Fc of mouse IgG2c","Rat insulin 2",{"$nulls":10},"Normal",null,"C57BL/6-H2-K<bm1>","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,null,"WEHI #560","true",null,"Andrew","Lew","Walter and Eliza Hall Institute of Medical Research","lew@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5258,"DMP1.gp130fl/fl","C57BL/6-Il6st<tm1Wme> Tg(Dmp1-cre)1Jqfe",null,"Recessive","interleukin 6 signal transducer","Il6st","Normal","CD130, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Werner Mueller","Il6st<tm1Wme>","MGI:1931239","13",{"$nulls":15},"Yes","transgene insertion 1, Jian Q Feng","dentin matrix protein 1 (Dmp1)","Cre expression restricted to dontoblasts and osteocytes",{"$nulls":9},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-21","Cryopreserved sperm",20,0,null,"276","false",null,"Natalie","Sims","St Vincent's Institute","nsims@svi.edu.au",{"$nulls":3},"Natalie","Sims","nsims@svi.edu.au","N/A","N/A","No"]
[7548,"APN 388","C57BL/6N-A<tm1Brd> Gprc6a<tm1a(EUCOMM)Wtsi>/MarpApb",null,"Recessive"," G protein-coupled receptor, family C, group 6, member A","Gprc6a ",null,null,"MGI:2429498  ","G protein-coupled receptor, family C, group 6, member A; targeted mutation 1a, Wellcome Trust Sanger Institute","Gprc6atm1a(EUCOMM)Wtsi","MGI:4461735","10",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-12-19","Cryopreserved sperm",46,0,"Monash",null,"false",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MARP/2012/105","PC1-N53/13","No"]
[5848,"IFNGR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5263,"RARgamma","C57BL/6-Rarg<tm1Ipc>/StvApb",null,"Recessive","retinoic acid receptor, gamma","Rarg","Nil","MGC:11555, MGC:18523, RAR gamma 2, RARgamma2","MGI:97858","retinoic acid receptor, gamma; targeted mutation 1, Pierre Chambon","Rarg<tm1Ipc>","MGI:1931079","15",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit stunted growth, homeotic transformations of the rostral axial skeleton and tracheal cartilage, Harderian gland agenesis, high postnatal mortality, and male sterility.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-10-21","Cryopreserved sperm",63,0,"St V","227","false",null,"Louise","Purton","St Vincent's Institute","lpurton@svi.edu.au",{"$nulls":3},"Louise","Purton","lpurton@svi.edu.au","N/A","N/A","No"]
[5266,"OsxCre/RARalphaRARgamma","C57BL/6-Rara<tm3lpc> Rarg<tm3lpc> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc",null,"Recessive","retinoic acid receptor, alpha","Rara","Normal","RAR alpha 1, RARalpha1","MGI:97856","retinoic acid receptor, alpha; targeted mutation 3, Pierre Chambon","Rara<tm3Ipc>","MGI:2386106","11",{"$nulls":15},"Yes","transgene insertion 1, Andrew P McMahon","Sp7",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown","10",null,null,"No","2010-10-21",null,0,0,null,"St V #231","true",null,"Louise","Purton","St Vincent's Institute","lpurton@svi.edu.au",{"$nulls":3},"Louise","Purton","lpurton@svi.edu.au","N/A","N/A","No"]
[5268,"LLD KO","C57BL/6-Thdb<tm2Emc>",null,"Recessive","thrombomodulin","Thbd","Nil","CD141, TM","MGI:98736","thrombomodulin; targeted mutation 2, Edward M Conway","Thbd<tm2Emc>","MGI:3712468","2",{"$nulls":15},"No",{"$nulls":12},"Increased sensitivity to induced morbidity/mortality: during hypoxia 7 of 18 mice die with diffuse lung fibrin depositions compared to only one wild-type mouse.Abnormal leukocyte physiology: leukocyte accumulation in the lung is increased.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-24",null,0,0,null,"StV #401","true",null,"Harshal","Nandurkar","St Vincent's Institute","harshal.nandurkar@svhm.org.au",{"$nulls":3},"Harshal","Nandurkar","harshal.nandurkar@svhm.org.au","N/A","N/A","No"]
[3554,null,"C57BL/6-Tg(UBC-GFP)30Scha/JWehi",null,"Semi-dominant",{"$nulls":25},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":10},"Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These mice express GFP in all tissues examined. Expression levels vary between certain hematapoetic cell types. GFP expression is uniform within a cell type lineage and remains constant throughout development. T cells have a 2-fold higher GFP expression than CD19+B220+ B cells or peripheral blood cells. Leukocytes and red blood cells from homozygous transgenic mice fluoresce at approximately twice the level of cells from hemizygous mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31",null,0,0,"WEHI","1266","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7740,"SB12","STOCK Gt(ROSA)26Sor<tm2(sb11)Njen> TgTn(sb-T2/Onc3)12775Njen/Nci",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Nancy A Jenkins","Gt(ROSA)26Sor<tm2(sb11)Njen>","MGI:3839796","6",{"$nulls":16},"transgenic transposon concatemer 12775, Nancy A Jenkins","CAG promoter ",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Poor",{"$nulls":3},"No","2014-09-15","Cryopreserved sperm",60,0,null,null,"false",null,"Giselle","Bellamy","The Canberra Hospital","giselle.bellamy@health.nsw.gov.au",{"$nulls":6},"1309-004A","2013-05","No"]
[3556,"Traube","CBA.129-Aatf<Gt(pGT1.8geo)3Pgr>",null,"Recessive","apoptosis antagonizing transcription factor","Aatf","Nil","Che-1, MGC:35916, Trb, traube","MGI:1929608","gene trap 3, Peter Gruss","Aatf<Gt(pGT1.8geo)3Pgr>","MGI:2176283","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethality before implantation * embryos die after failing to undergo compactionEmbryogenesisDecreased embryo size * 50% reduction in total cell numberAbnormal blastocyst morphology * E1.5 embryos cultured in vitro do not form blastocysts as wild type and instead start to decompact and die after 72 hours of cultureFailure to form blastocele * embryos have not formed a blastocoel cavity by E3.5Embryonic growth arrest * development is arrested at the compacted morula stage at E2.5Growth/SizeDecreased embryo size * 50% reduction in total cell numbercellularAbnormal cell content/ morphology* embryos have few ribosomes, polyribosomes, and rough endoplasmic reticulum* greatly enlarged secretory vesicles are seen in embryosDecreased cell proliferation* embryos exhibit severe reduction in cell proliferation before blastocyst formation",null,"CBA","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2008-07-31",null,0,0,null,"WEHI #1296","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8493,"BALB.Gasa1","BALB/c-Gasa1<C57BL/6>/BaxApb",null,"Recessive",{"$nulls":28},"gastritis type A susceptibility locus 1","Gasa1",null,null,"MGI:1346075","gastritis type A susceptibility locus 1; C57BL/6","Gasa1<C57BL/6>","MGI:2155785","4","This allele confers resistance to autoimmune gastritis compared to BALB/cCrSlc. ",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-05-31","Cryopreserved sperm",49,0,null,null,"false",null,"Alan","Baxter","James Cook University","serrin.rowarth@jcu.edu.au",{"$nulls":8},"No"]
[5366,"RIP7-Socs1","C57BL/6-Tg(Ins2-Socs1)21Wehi",null,"Dominant",{"$nulls":25},"suppressor of cytokine signaling-1","rat insulin promoter 2 (RIP7)",{"$nulls":10},"SOCS-1 overexpression inhibits β cell responsiveness to IFNs.SOCS-1 overexpression in β cells prevents progression to diabetes in CD8<+>TCR transgenic NOD8.3 mice.Transgenic mice develop massive insulitis.SOCS-1 overexpression prevents the induction of Fas expression on β cells in NOD8.3 mice and in response to TNF and IFN-γ.Cells isolated from transgenic mice have a reduced ability to stimulate 8.3 T cell proliferation and IFN-γ production.SOCS-1 overexpression suppresses islet expression of IL-15 in response to TNF and IFN-γ.β cell up-regulation of Fas and class I MHC expression in mice adoptively transferred with diabetogenic splenocytes is also prevented by SOCS-1 overexpression.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #53","true",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8487,"C57BL/6.Myd88-/-","B6.129P2-Myd88<tm1Aki>/BaxApb",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":28},"Increased apoptosis:*5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells.Increased physiological sensitivity to xenobiotic:*Knockout mice are more susceptible to bleomycin-induced lung injury.Increased dendritic cell number:*Increased numbers of dendritic cells in brains of mice infected with Plasmodium.Abnormal dendritic cell differentiation:*Dendritic cell maturation fails to occur in vivo upon exposure to TLR9 agonists.Abnormal immune system physiology:*Response to LPS and CpG is completely abrogated.      Abnormal dendritic cell physiology:      *Cytokine secretion elicited by zymosan or LPS is impaired.      *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40, IL-6 and interferon-gamma relative to wild-type mice.      Abnormal macrophage physiology:      *TNF production is impaired in thioglycollate-elicited macrophages treated with intact zymosan.      *Cytokine production by macrophages cultured with P. carinii cysts is reduced compared to wild-type.      Abnormal NK cell physiology:      *NK cells fail to make IFN-gamma in response to injections of TLR9 agonists.      Abnormal T cell physiology:      *Induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonists, was severely impaired.      Abnormal cytokine secretion:      *LPS-induced cytokine production by BMDCs is almost abolished compared to controls and Myd88-sufficient mutants.         Abnormal chemokine secretion:         *Hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice.         Decreased interferon-alpha secretion:         *CpG-A or RNA polyuridylic acid induced production of interferon-alpha was abolished in plasmacytoid dendritic cells.         Decreased interferon-gamma secretion:         *Less up regulation of INF-gamma in Plasmodium infection.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less interferon-gamma.         Decreased interleukin-12 secretion:         *After stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.         Decreased interleukin-12b secretion:         *Less upregulation of IL-12b in Plasmodium infection.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice.         Decreased interleukin-6 secretion:         *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, IL-6 secretion is reduced.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-6 relative to wild-type mice.         Decreased tumor necrosis factor secretion:         *Less upregulation of TNF-alpha in Plasmodium infection.         *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.         *After stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.      Decreased inflammatory response:      *In a model of induced pneumococcal meningitis-associated labyrinthitis, homozygotes exhibit a significantly lower granulocytic infiltration of the labyrinth and increased bacterial density in the cochlea at 24 hrs post-infection relative to wild-type control mice.      Abnormal response to infection:      *Following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a decreased immune response in terms of TNF and IL-6 secretion and response to CpG.         Decreased susceptibility to parasitic infection:         *Resistant to cerebral malaria but eventually die of extremely high parasitemia.         Increased susceptibility to viral infection:         *Increased susceptibility to encephalomyocarditis virus (EMCV) infection compared to wildtype.Abnormal susceptibility to hearing loss:*In a model of induced pneumococcal meningitis-associated labyrinthitis, homozygotes exhibit significantly less hearing impairment at 24 hrs post-infection in response to click, 1- or 10-kHz stimuli relative to wild-type control mice.Abnormal neuron differentiation:*Improved differentiation of progenitor cells into neurons.*Survival of newly formed neurons is reduced.Abnormal nervous system physiology:*After cold induced cortical injury, recruitment of neutrophiles to lesion site is reduced by 85% in comparison to controls.*Cold induced cortical lesion volume is reduced by 25% compared to controls.*Fewer cortical cells have damaged DNA compared to controls after cold induced cortical injury.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-05-31","Cryopreserved sperm",49,0,"Moss Vale",null,"false",null,"Alan","Baxter","James Cook University","serrin.rowarth@jcu.edu.au",{"$nulls":8},"No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[7742,"ENU19:B6:MRPS34","C57BL/6JAnu-Mrps34<m1Anu>/AnuApb",null,"Recessive","mitochondrial ribosomal protein S34","Mrps34","Unknown","0610007F04Rik, 5330430D13Rik, Tce2 ","MGI:1930188 ",{"$nulls":3},"17","ENSMUSG00000038880","ENSMUST00000043907","Mrps34-001","203","252","T to C","ENSMUSE00000747863","1","68","Leucine to Proline",{"$nulls":18},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","mut x mut","No","2014-09-23","Cryopreserved sperm",22,0,"ANU",null,"false",null,"Oliver","Rackham","The University of Western Australia","Alanna.Osborne@anu.edu.au",{"$nulls":3},"Alanna","Osborne","Alanna.Osborne@anu.edu.au","A2011/41",null,"No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[7555,"ENU25:041:Casd1:B6","C57BL/6NCrlAnu-Casd1<m1Anu>/Apb","C57BL/6NCrlAnu-Casd1<m1Anu>/Apb","Recessive","CAS1 domain containing 1","Casd1","Unknown","Cast1, MGC:6840","MGI:2384865",{"$nulls":3},"6","ENSMUSG00000015189","ENSMUST00000015333","Casd1-001",{"$nulls":7},"4557979","1",null,null,"CTAATATTTACACTACCGTGCTTTACTGTTATAGGCAATGATTCGTGTGAATACCTTCTC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-12-19",null,0,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[5260,"OsxCregp130","C57BL/6-Il6st<tm1Wme> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc",null,"Recessive","interleukin 6 signal transducer","Il6st","Normal","CD130, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Werner Mueller","Il6st<tm1Wme>","MGI:1931239","13",{"$nulls":15},"Yes","transgene insertion 1, Andrew P McMahon","Sp7 transcription factor 7 (Sp7) (osterix, Osx)","Cre expression restricted to bone",{"$nulls":9},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-21",null,0,0,null,"395","true",null,"Natalie","Sims","St Vincent's Institute","nsims@svi.edu.au",{"$nulls":3},"Natalie","Sims","nsims@svi.edu.au","N/A","N/A","No"]
[4697,"NOD260/260","NOD.Cg-Socs1<tm1Wehi>/WehiApb",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Unknown","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 1, Walter and Eliza Hall Institute of Medical Research","Socs1<tm1Wehi>","MGI:1934607","16",{"$nulls":15},"No",{"$nulls":12},"postnatal lethality (J:51281) mice die prior to weaning digestive/alimentary system pancreas inflammation (J:51281) monocytic infiltration postnatal growth retardation (J:51281) hematopoietic system decreased B cell number (J:51281) progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood small thymus (J:51281) thymus hypoplasia (J:51281) fatty liver",null,"NOD","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2009-04-07","Cryopreserved sperm",110,0,"St V","061","false",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[8585,"ENU42:108:P2rx7:G3","C57BL/6NCrlAnu-P2rx7<m1Anu>/AnuApb",null,"Recessive","purinergic receptor P2X, ligand-gated ion channel, 7","P2rx7",null,"P2X(7), P2X7R, P2X7 receptor","MGI:1339957",{"$nulls":3},"5",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-05","Cryopreserved sperm",33,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[5870,"K5Cre;Ptc1/Ptc2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[8561,"Cav1","BALB/c-Cav1<tm1>/OnjcriApb",null,"Recessive","caveolin 1, caveolae protein","Cav1","Unknown","Cav-1, caveolin-1","MGI:102709",{"$nulls":3},"6",{"$nulls":28},"Null mutant females do not breed well and pups may be unable to feed due abnormal mammary gland development during pregnancy and abnormal lactation in the mother and/or low levels of fat tissue.","Normal","BALB/c","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-09-18","Cryopreserved sperm",50,0,null,null,"false",null,"Caroline","Bell","Olivia Newton John Cancer Research Institute","caroline.bell@onjcri.org.au",{"$nulls":8},"No"]
[7557,"ENU27:002:PIK3IP1:B6","C57BL/6NCrlAnu-Pik3ip1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Pik3ip1<m1Anu>/AnuApb","Recessive","phosphoinositide-3-kinase interacting protein 1","Pik3ip1","Unknown","1500004A08Rik, 5830455E04Rik","MGI:1917016","phosphoinositide-3-kinase interacting protein 1; mutation 1, The Australian National University","Pik3ip1<m1Anu>","MGI:5563439","11","ENSMUSG00000034614","ENSMUST00000045153","Pik3ip1-001","313","847","A to G","ENSMUSE00000314294","4","105","Serine to Alanine",{"$nulls":4},"CCTGCGAGGACGTGAGTTGCCCAGAGACCACTTCCCAAGCACCACCGCCATCCTCTGCCAT",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-12-19","Cryopreserved sperm",30,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[5372,"B6 gR/GP","B6.Cg-Tg(Ins2-dnIfngr1)10Wehi Tg(ins2-GP)34-20Olds",null,"Dominant",{"$nulls":25},"dominant negative interferon gamma receptor","rat insulin promoter (Ins2) (RIP)",{"$nulls":10},"These mice were still capable of upregulatingMHC class I on islets, similarly to other cytokine-deficientmice, which was sufficient to render RIP-R/glycoprotein+ islets susceptible to perforin-mediated lysis in vitro. Surprisingly, such double transgenic mice did not develop type 1 diabetes to a significant degree (<10%, 1 of 12 mice F3 or 0 of 5 mice F4, compared with a >50% type 1 diabetes incidence in RIP-glycoprotein single transgenic controls.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-21",null,0,0,null,"StV #77","true",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6674,"NORIEGAS","BALB/c.B6-Stat6<tm1Aki>/ANU/Ausb",null,"Recessive","signal transducer and activator of transcription 6","Stat6","Nil",null,"MGI:103034","signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira","Stat6<tm1Aki>","MGI:2386746","10",{"$nulls":30},"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2093","true",null,"Malcolm","Starkey","Moss Vale","malcolm.starkey@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5886,"Lifeact-RFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7560,null,"SJL/Mrit-MRI28562","SJL/Mrit-MRI28562","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display a slight decrease growth phenotype","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2014-01-07","Cryopreserved sperm",60,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[4188,"(SOCS1/RIP)","B6.Cg-Socs1<tm1Wehi> Socs1<tm3Wehi> Tg(Ins2-cre)25Mgn/Apb",null,"Recessive","suppressor of cytokine signaling 1","Socs1","Unknown","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research","Socs1<tm3Wehi>","MGI:2656917","16",{"$nulls":15},"No",{"$nulls":42},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A"]
[7748,"DBC3-cre","C57BL/6-Brinp3<tm1.1>/MarpApb",null,"Recessive","bone morphogenetic protein/retinoic acid inducible neural specific 3","Brinp3","Nil","B830045N13Rik, Fam5c","MGI:2443035",{"$nulls":3},"1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Unknown","Unknown","Unknown","No","Good","10",null,"From hetrozygous breeding","No","2014-10-02",null,0,0,"Monash",null,"true",null,"Susie","Berkowicz","Monash University","Susie.berkowicz@monash.edu",{"$nulls":6},"SOBS/B/2008/30BC","PC2","No"]
[5568,"Klf3-LoxP","B6;129-Klf3<tm?Merc>",null,"Dominant","Kruppel-like factor 3 (basic)","Klf3",null,"BKLF, Bklf, Tef-2","MGI:1342773",{"$nulls":3},"5",{"$nulls":28},"Unknown","Unknown","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-26","Cryopreserved sperm",50,0,null,null,"true",null,"Merlin","Crossley","The University of New South Wales","m.crossley@unsw.edu.au","BABS","UNSW","NSW","Stella","Lee","s.h.lee@unsw.edu.au","09/128A","N/A","No"]
[5273,"MB (p535) ; B6-TgN(MsLLD-MUSMAlbumin)XMZ","C57BL/6-Tg(Alb-Thdb<sLLD>)Xmz",null,"Dominant",{"$nulls":25},"Mouse soluble lectin-like domain of thrombomodulin with FLAG tag","albumin","Strong",{"$nulls":9},"Strong expression of mouse soluble lectin-like domain in liver and secretion into circulating blood; no deleterious effects  Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-26",null,0,0,null,"StV #168","true",null,"Harshal","Nandurkar","St Vincent's Institute","harshal.nandurkar@svhm.org.au",{"$nulls":3},"Harshal","Nandurkar","harshal.nandurkar@svhm.org.au","N/A","N/A","No"]
[4893,"Phenomix","Phx",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2009-09-30","Cryopreserved sperm",710,0,null,null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","J.APF.13.08","N/A","No"]
[8510,"NOD.H2b.Nkrplb.CD-1","NOD.H2b.Nkrplb.CD-1",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Difficult breeders. Have had to restart the breeding, multiple times due to the difficulty in getting them homozygous. Seems homozygous mice do not breed. Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.Knockout lacking the CD1 antigen complex gene",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2018-06-08","Cryopreserved sperm",49,0,null,null,"false",null,"Alan","Baxter","James Cook University","serrin.rowarth@jcu.edu.au",{"$nulls":8},"No"]
[5046,"KRN14","KRN:014",null,"Recessive","glutamate receptor, ionotropic, kainate 4","Grik4","Unknown","GluRgamma1, KA-1, KA1","MGI:95817",{"$nulls":3},"9",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis, no GPI autoantibodies in KRN/H2g7 model.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2010-02-26","Cryopreserved sperm",107,0,null,null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","J.APF.20.08","N/A","No"]
[5040,"APN21","129/Ola-Rab10<Gt(XC820)Byg>/MAS",null,"Recessive","RAB10, member RAS oncogene family","Rab10","Unknown",null,"MGI:105066","RAB10, member RAS oncogene family; gene trap XC820, BayGenomics","Rab10<Gt(XC820)Byg>","MGI:4125038","12",{"$nulls":28},"Unknown","Unknown","C57BL/6 x 129/OlaHsd","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",80,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","deborah.bianco@monash.edu","MMCA SOP 2007/02","PC1-N09/07","No"]
[5280,"NODBID/8.3","NOD.Cg-Bid<tm1.1Ast> Tg(TcraTcrbNy8.3)1Pesa",null,"Recessive","BH3 interacting domain death agonist","Bid","Nil",null,"MGI:108093","BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser","Bid<tm1.1Ast>","MGI:4440571","6",{"$nulls":15},"No","transgene insertion 1, Pere Santamaria","TCR alpha and beta enhancers",{"$nulls":10},"Mice may develop diabetes faster than wildtype.",null,"NOD/Lt","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-28",null,0,0,null,"StV #418","true",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":3},"Helen","Thomas","hthomas@svi.edu.au","N/A","N/A","No"]
[{"$nulls":30},"human cellular glutathione peroxidase (Gpx-1) tagged with a histidine (6xHis) tag","H2-K<b>"]
[818,"Grb14 KO","B6.129-Grb14<tm1Daly>",null,"Recessive","growth factor receptor bound protein 14","Grb14","Nil",null,"MGI:1355324","targeted mutation 1, Roger J Daly","Grb14<tm1Daly>","MGI:3029164","2",{"$nulls":15},"Yes",{"$nulls":12},"Improved glucose tolerance, lower circulating insulin levels, and increased incorporation of glucose into glycogen in the liver and skeletal muscle.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"true",null,"Roger","Daly","Garvan Institute","r.daly@garvan.org.au",{"$nulls":3},"Roger","Daly","r.daly@garvan.org.au","N/A","N/A","No"]
[7070,"Momme D4","FVB/NJ-Smarca5<MommeD4> Tg(Hba1-Gfp)1Ew/QimrApb",null,"Semi-dominant","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5","Smarca5","Unknown","4933427E24Rik, D030040M08Rik, D330027N15Rik, MommeD4, Snf2h","MGI:1935129","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; modifiers of murine metastable epiallele D4","Smarca5<MommeD4>","MGI:3586551","8","ENSMUSG00000031715","ENSMUST00000043359","Smarca5-001","1558","1959","T to A","ENSMUSE00001218842","12","520","Tryptophan to Arginine",{"$nulls":4},"TATTAGACATTTTGGAAGATTATTGCATGTGGAGAAATTATGAGTACTGCAGGTTGGATGG",null,"transgene insertion 1, Emma Whitelaw","human alpha-globin promoter and enhancer region",{"$nulls":10},"Homozygous lethality E17","Normal","FVB/NJ","No","No","Yes","No","No","Yes","No","Good",null,null,"MommeD4<+/->;Tg(Hba1-Gfp)1Ew<tg/tg> x Tg(Hba1-Gfp)1Ew<tg/tg>","No","2012-08-29","Cryopreserved sperm",49,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","e.whitelaw@qimr.edu.au",{"$nulls":3},"Joanne","Sutton","joanne.sutton@qimr.edu.au","A0812609","p1224","No"]
[7564,"ENU25:048:P2ry10:B6","C57BL/6NCrlAnu-P2ry10<m1Anu>/AnuApb","C57BL/6NCrlAnu-P2ry10<m1Anu>/AnuApb","X-linked","purinergic receptor P2Y, G-protein coupled 10","P2ry10","Unknown","5830408N17Rik, P2Y10","MGI:1926076","purinergic receptor P2Y, G-protein coupled 10; mutation 1, The Australian National University","P2ry10<m1Anu>","MGI:5648450","X","ENSMUSG00000050921","ENSMUST00000053375","P2ry10-001","123","497","T to A","ENSMUSE00000710686","3","41","Serine to Arginine",{"$nulls":4},"ATATTCATCCCGGGTCTCCTGGCTAACAGTGCAGCCCTGTGGGTTCTGTGCCGCTTCATCA",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2014-01-14","Cryopreserved sperm",60,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[8514,"ENU42:G2","ANU:ENU42:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2018-06-12","Cryopreserved sperm",3469,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8516,"MR1-tom","C57BL/6-Mr1<tm1>",null,"Recessive","major histocompatibility complex, class I-related","Mr1","Nil","H2ls, MR1","MGI:1195463",{"$nulls":3},"1",{"$nulls":28},"Essentially normal but lacks a T cell known as a MAIT cell. ","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-14",null,0,0,null,null,"false",null,"Hamish","McWilliam","The Peter Doherty Institute","hamish.mcwilliam@unimelb.edu.au",{"$nulls":8},"No"]
[8568,"ASD801:TgPKR","B6(Cg)-Tg(Vav1-EIF2AK2)#Wsmay/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion, W May","vav1",{"$nulls":11},"peripheral blood counts from TgPKR mice decrease with age in association with dysplastic marrow changes. TgPKR mice have reduced colony-forming capacity and the colonies also are more sensitive to hematopoietic stresses. Furthermore, TgPKR mice have fewer hematopoietic stem/progenitor cells (HSPCs), and the percentage of quiescent (G0) HSPCs is increased. Importantly, treatment of TgPKR bone marrow (BM) with a PKR inhibitor specifically rescues sensitivity to growth factor deprivation. In contrast, marrow from PKR knockout (PKRKO) mice has increased potential for colony formation and HSPCs are more actively proliferating and resistant to stress. Significantly, TgPKR HSPCs have increased expression of p21 and IFN regulatory factor, whereas cells from PKRKO mice display mechanisms indicative of proliferation such as reduced eukaryotic initiation factor 2α phosphorylation, increased extracellular signal-regulated protein kinases 1 and 2 phosphorylation, and increased CDK2 expression.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-21",null,0,0,"ANU",null,"false",null,"Si Ming","Man","The Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[8569,"Cd47 KO","B6.129-Cd47<tm1>/AnuApb",null,"Recessive","CD47 antigen (Rh-related antigen, integrin-associated signal transducer)","Cd47",null,"9130415E20Rik, B430305P08Rik, IAP, integrin-associated protein, Itgp","MGI:96617",{"$nulls":3},"16",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-24","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Chris","Parish","Australian National University","christopher.parish@anu.edu.au",{"$nulls":8},"No"]
[3591,"Phc1 Phc2 KO","Un-Phc1<tm1Os> Phc2<tm1Hko>",null,"Recessive","polyhomeotic-like 2 (Drosophila)","Phc2","Unknown","D130050K19Rik, D4Ertd810e, Edr2, Mph2","MGI:1860454","targeted mutation 1, Haruhiko Koseki","Phc2<tm1Hko>","MGI:3586989","4",{"$nulls":61},"N/A","N/A"]
[3599,null,"C57BL/6-Tg(Wnt1-Cre)",null,"Dominant",{"$nulls":25},"Cre recombinase","wingless-related MMTV integration site 1 (Wnt1), The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer.",{"$nulls":10},"The Wnt1 regulatory sequences initially direct expression of Cre recombinase in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-06",null,0,0,null,"WEHI #2037","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","voss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3518,null,"C57BL/6.Balb/c-Lmr1<C57BL/6J>Lmr2<C57BL/6J>",null,"Recessive","leishmaniasis resistance 1","Lmr1","Unknown",null,"MGI:1277203","leishmaniasis resistance 1; C57BL/6J ","Lmr1C57BL/6J","MGI:2446909","17",{"$nulls":15},"Yes",{"$nulls":12},"These mice are more susceptible to leishmaniasis infection than C57BL/6.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28",null,0,0,null,"WEHI #883","true",null,"Emanuela","Handman","Walter and Eliza Hall Institute of Medical Research","Handman@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[8520,"OGT-flox","B6.129-Ogt<tm1Gwh>/J",null,"Recessive","O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)","Ogt","Unknown","1110038P24Rik, 4831420N21Rik, OGT, Ogtl","MGI:1339639","O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); targeted mutation 1, Gerald W Hart","Ogt<tm1Gwh>","MGI:2387867","X",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-06-14","Cryopreserved sperm",50,0,null,null,"false",null,"Justine","Mintern","Bio21 Institute/UOM","jmintern@unimelb.edu.au",{"$nulls":8},"No"]
[7293,"B6/J - Blue G18","C57BL/6JAnu-redev-BlueG18",null,"Dominant",{"$nulls":39},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-03-21","Cryopreserved sperm",20,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[7112,"ENU22:Stxbp2","C57BL/6NCrlAnu-Stxbp2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Stxbp2<m1Anu>/AnuApb","Recessive","syntaxin binding protein 2","Stxbp2","Unknown","C79054, Munc-18-2, Munc18b, Munc-18b, muSec1, Sxtp2 ","MGI:107370","syntaxin binding protein 2; mutation 1, The Australian National University","Stxbp2<m1Anu>","MGI:5563406","8","ENSMUSG00000004626","ENSMUST00000160708","Stxbp2-001",{"$nulls":7},"3636354","11",null,null,"ACGATCTCTACCCTCTCCTACCATTACCTCAGGCCAACATCAAAGACCTGTCCCACATCC",{"$nulls":13},"Reduced fusion of cytolytic granules with cell membrane","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","none","3","het x het","No","2012-10-24","Cryopreserved sperm",32,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","Lisa.Miosge@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"Yes"]
[6530,"IL12?","B6.129S1-Il12b<tm1Jm>/ScrAusb?",null,"Recessive","interleukin 12b ","Il12b","Nil","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","interleukin 12b; targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*Increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls.Decreased circulating interferon-gamma level:*Serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls.Abnormal macrophage physiology:*Fewer than expected macrophages in the dermis of carcinogen treated skin.Abnormal granulocyte physiology:*Fewer than expected granulocytes in the dermis of carcinogen treated skin.Abnormal lymphocyte physiology:*Lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased.      Abnormal NK cell physiology:      *Mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls.      Abnormal CD8-positive T cell physiology:      *Dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin.Decreased susceptibility to type IV hypersensitivity reaction:*Specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type.Decreased interleukin-17 secretion:*Barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17.Increased susceptibility to bacterial infection:*Vaccination does not produce a protective response to M. tuberculosis.Decreased incidence of chemically-induced tumors:*Resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol.*However, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells.Abnormal alveolar process:*3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","384","true",null,"Jonathan","Sprent","Garvan Institute","j.sprent@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6638,"Circling ; ENU18PiDTau_ TBx1","STOCK Tbx1<enu37> Tg(Thy1-MAPT*K369I)K3Gotz/AnuApb",null,"Dominant","T-box 1","Tbx1",null,null,"MGI:98493","T-box 1; enu37","Tbx1<enu37>","MGI:5490246","16",{"$nulls":16},"transgene insertion K3, Jurgen Gotz","Thy1","neuron specific",{"$nulls":9},"Unknown","Head tilt:• head tilting and weavingBidirectional circling","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2011-11-02","Cryopreserved sperm",18,0,"ANU",null,"true",null,"Juergen","Goetz","Brain and Mind Research Institute","juergen.goetz@sydney.edu.au",{"$nulls":3},"Robert","Tunningley","robert.tunningley@anu.edu.au","J.APF.17.08","na","No"]
[5296,"B6.EPCR.Tg ; CBA/B6-Tg(HUEPCR)","CBA;B6-Tg(H2-K<b>-EPCR)",null,"Recessive",{"$nulls":25},"human protein C receptor, endothelial","H2-K<b>","Strong, endothelial cells and neutrophils",{"$nulls":9},"Unknown",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-29","Cryopreserved sperm",50,0,null,"StV #163 (162, 161)","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","N/A","N/A","No"]
[5179,"16FOX 004 B6.129-Tg(FoxP3-GFP)","ENU16FOX:004 Foxp3<tm2Ayr>",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436",null,null,"MGI:3574964","X",{"$nulls":15},"No",{"$nulls":12},"Malocclusion with secondary immune phenotypeCells from the Foxp3-gfp background strain that express FoxP3 fluoresce green, predominantly T cells","Normal ","129 x C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Good",null,null,"unaffected sib intercross","No","2010-07-19","Cryopreserved sperm",40,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":6},"J.APF.19.08","N/A","No"]
[5179,"16FOX 004 B6.129-Tg(FoxP3-GFP)","ENU16FOX:004 Foxp3<tm2Ayr>",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown",{"$nulls":45},"J.APF.19.08","N/A"]
[3316,"FATT-C57","C57BL/6-Lepr<FATT>/Apb",null,"Recessive","Leptin Receptor","LepR","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, OB-RGRP, obese-like, obl, Obr","MGI:104993","FATT","Lepr<FATT>",null,"4",{"$nulls":15},"Yes",{"$nulls":12},"The homozygote mutant has juvenile obesity, florid diabetes. The adult is hypogonadal and does not breed, and had an increased body length (10-20%).","There is a slight change in adipose tissue distribution and liver weight but no other significant changes. ","129Sv/EvTac x C57BL/6","Yes","No","Yes","Yes","No","Yes","Yes","Good","4",null,"Heterozygous FATT-C57/BL6 mice crossed with C57/BL6 working towards a C57/BL6 background. Homozygous mutants are not fertile/do not breed. ","No","2008-06-09","Cryopreserved sperm",130,0,null,null,"false",null,"Brian","Oldfield","Monash University","brian.oldfield@med.monash.edu.au",{"$nulls":3},"Brian","Oldfield","brian.oldfield@med.monash.edu.au","N/A","N/A","No"]
[5310,"ENU15 CHINA 075c B6 G3","ENU15China:075c",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Reduced B cell population. May possibly be fertility defects too because affecteds don't breed. Phenotyping via peripheral blood FACS.",null,null,"Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-11-08","Cryopreserved sperm",20,0,null,null,"true",null,"Adrian","Liston","University of Leuven","adrian.liston@gmail.com",{"$nulls":3},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","J.APF.19.08","N/A","No"]
[269,null,"C57BL/6-Gzma<tm1Smn> Prf1<tm1Sdz>",null,"Recessive","granzyme A","Gzma","Unknown","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"Yes",{"$nulls":14},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-30",null,0,0,null,null,"true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[269,null,"C57BL/6-Gzma<tm1Smn> Prf1<tm1Sdz>",null,"Recessive","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":61},"N/A","N/A"]
[5543,"ENU14Yaa:032b","B6.SB-Lyn<m2Anu>/AnuApb","B6.SB-Lyn<m2Anu>/AnuApb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn",null,"Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; mutation 2, The Australian National University","Lyn<m2Anu>","MGI:5563397","4","ENSMUSG00000042228","ENSMUST00000041377","Lyn-001",{"$nulls":7},"3683632","9",null,null,"CTACATCATCACCGAGTTCATGGCTAAGGGTGAGTGGCATCACGAGTCTGTACCCCTAAA",{"$nulls":13},"Increased % immature B cells, and reduced % mature B cells (Almost no Mature B cells)",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-07-27","Cryopreserved sperm",45,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Heather","Domaschenz","heather.domaschenz@anu.edu.au","J.APF.16.08","N/A","No"]
[5900,"MacGreen",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[8586,"Mx1Cre.Sphk1floxed.Spk2KO","B6.129-Sphk1<tm2Cgh> Sphk2<tm1Rlp> Tg(Mx1-cre)1Cgn/UsaApb",null,"Recessive","sphingosine kinase 1","Sphk1","Unknown","1110006G24Rik, SK1","MGI:1316649","sphingosine kinase 1; targeted mutation 2, Shaun R Coughlin","Sphk1<tm2Cgh>","MGI:3707997","11",{"$nulls":16},"transgene insertion 1, University of Cologne","Mx dynamin-like GTPase 1 (Mx1)",{"$nulls":10},"Whilst the Cre is inactivated these mice are normal","Whilst the Cre is inactivated these mice are normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-12","Cryopreserved sperm",40,0,null,null,"false",null,"Stuart","Pitson","Centre for Cancer Biology, University of South Australia","stuart.pitson@unisa.edu.au",{"$nulls":8},"No"]
[8586,"Mx1Cre.Sphk1floxed.Spk2KO","B6.129-Sphk1<tm2Cgh> Sphk2<tm1Rlp> Tg(Mx1-cre)1Cgn/UsaApb",null,"Recessive","sphingosine kinase 2","Sphk2","Nil",null,"MGI:1861380","sphingosine kinase 2; targeted mutation 1, Richard L Proia","Sphk2<tm1Rlp>","MGI:3611080","7"]
[8587,"F2rl1 fl","C57BL/6N-F2rl1<tm1c(EUCOMM)Wtsi>/MarpApb",null,"Recessive","coagulation factor II (thrombin) receptor-like 1","F2rl1",null,"Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2","MGI:101910","coagulation factor II (thrombin) receptor-like 1; targeted mutation 1c, Wellcome Trust Sanger Institute","F2rl1<tm1c(EUCOMM)Wtsi>","MGI:6151132","12",{"$nulls":28},"Normal",null,"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-17","Cryopreserved sperm",30,0,null,null,"false",null,"Charles","Pagel","The University of Melbourne","cpagel@unimelb.edu.au",{"$nulls":8},"No"]
[8588,"MDX:PAR2","B6.B10-Dmd<mdx> F2rl1<tm1Cgh>/Apb",null,"Recessive","dystrophin, muscular dystrophy","Dmd",null,"Dp427, Dp71, Duchenne muscular dystrophy, dys, mdx, pke, X-linked muscular dystrophy","MGI:94909","mdx & F2rl1","dystrophin, muscular dystrophy; X linked muscular dystrophy","Dmd<mdx>","X",{"$nulls":28},"Dystrophic (mdx)PAR2 deficiency","Normal","C57BL/6 ; C57BL/10","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-10-17","Cryopreserved sperm",40,0,null,null,"false",null,"Charles","Pagel","University of Melbourne","cpagel@unimelb.edu.au",{"$nulls":8},"No"]
[7768,"ONCtgN","C57BL/6-Tg(Bglap)/Ausb",null,"Dominant",{"$nulls":25},"bone gamma carboxyglutamate protein",{"$nulls":11},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-10-12",null,0,0,"ABR - Moss Vale","3699","true",null,"Paul","Baldock","Garvan Institute","p.baldock@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[3516,"Aiolos Knockout","129-Ikzf3<tm1Kge>/Wehi",null,"Recessive","IKAROS family zinc finger 3","Ikzf3","Nil","5830411O07Rik, Aiolos, Zfpn1a3","MGI:1342542","targeted mutation 1, Katia Georgopoulos","Ikzf3<tm1Kge>","MGI:2388132","11",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE",null,"129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28",null,0,0,null,"WEHI #863","true",null,"Li","Wu","Walter and Eliza Hall Institute of Medical Research","wu@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[8532,"ENU41:G3","ANU:ENU41:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2018-07-10",null,0,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8533,"ENU42:G3","ANU:ENU42:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2018-07-10","Cryopreserved sperm",286,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[6693,"129R","R1-129/Ausb",{"$nulls":39},"None",null,"R1-129","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2177","true",null,"Edna","Hardeman",{"$nulls":8},"N/A","N/A","No"]
[1548,"WB6","C57BL/6-Tyr<c-2j>/AnuApb",null,"Recessive","tyrosinase","Tyr","Nil","skc35","MGI:98880","tyrosinase; albino 2 Jackson","Tyr<c-2J>","MGI:1855985","7",{"$nulls":15},"No",{"$nulls":12},"Absent skin pigmentation:* mice lack pigmentation in the skin and eyes* mice lack detectable amounts of melanin in the hairbulbs",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",150,0,"ANU","002","true",null,"Klaus","Matthaei","The Australian National University","klaus.matthaei@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[2434,"Laxman:Hamlet","C57BL/6-Tg(H2<k>-sHELdimer)/Apb Tg(IghelMD4)4Ccg/AnuApb",null,"Recessive",{"$nulls":25},"soluble Hen Egg Lysozyme dimeric molecule","H-2K<b> promoter","High",{"$nulls":10},"High serum expression of dimeric soluble HEL.B cells express immunoglobulin that has a high affinity for hen egg lysozyme antigen (HEL).","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-01-13","Cryopreserved sperm",75,0,"ANU","229","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","N/A","N/A","No"]
[4474,"SPC-rtTA","C.FVB/N-Tg(SFTPC-rtTA)5Jaw/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 5, Jeffrey A Whitsett","human SFTPC (SPC) (surfactant protein-C)","respiratory epithelial cells",{"$nulls":10},"The human SFTPC promoter is active in respiratory epithelial cells.","BALB/c x FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-02-22","Cryopreserved sperm",165,0,"ANU","166","false",null,"Di","Webb","The Australian National University","dianne.webb@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[7575,"37L1null","B6;129S1/SvImJ-Gpr37l1<tm1>/Apb",null,"Dominant","G protein-coupled receptor 37-like 1","Gpr37l1","Nil","CAG-18, D0Kist8","MGI:1928503",{"$nulls":3},"1",{"$nulls":28},"Elevated blood pressure","Unknown. Potentially elevated blood pressure.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","unknown","unknown","hom x hom","No","2014-01-20","Cryopreserved sperm",50,0,null,null,"false",null,"Nicola","Smith","Victor Chang Cardiac Research Institute","n.smith@victorchang.edu.au",{"$nulls":3},"Nicola","Smith","n.smith@victorchang.edu.au","13/30","2010/3025","No"]
[5208,"Line:TF23","FVB/NJ-Tg(Prm1-Fgfr1*)4-9/MarpApb",null,"Dominant",{"$nulls":25},"mutant fibroblast growth factor receptor 1","Prm1","restricted to sperm",{"$nulls":10},"Mating of transgenic mice showed a significant reduction in pups per litter compared with wild-type littermates. Further analysis demonstrated that this subfertility was driven by a combination of reduced daily sperm output and a severely compromised ability of those sperm that were produced to undergo capacitation prior to fertilization. An analysis of key signal transduction proteins indicated that FGFR-1 is functional on wild-type sperm and probably signals via the phosphatidylinositol 3-kinase pathway. FGFR-1 activation also resulted in the downstream suppression of mitogen activated protein kinase signaling. These data demonstrate the FGFR-1 is required for quantitatively and qualitatively normal spermatogenesis and has a key role in the regulation of the global tyrosine phosphorylation events associated with sperm capacitation.","FVB/NJ","Yes","Yes","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2010-08-23","Cryopreserved sperm",30,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","moira.o'bryan@monash.edu",{"$nulls":3},"Moira","O'Bryan","moira.O'Bryan@monash.edu","N/A","N/A","No"]
[6858,"UNC CF null mouse ","B6.129P2-Cftr<tm1Unc>/J",null,"Recessive","cystic fibrosis transmembrane conductance regulator homolog","Cftr","Nil","Abcc7","MGI:88388","cystic fibrosis transmembrane conductance regulator homolog; targeted mutation 1, University of North Carolina","Cftr<tm1Unc>","MGI:1856709","6",{"$nulls":28},"Poor body weight gain, females have low fertility; early death unless high fat diet with mild diahoreal agent to prevent gut obstruction.  Poor survival.  Upper incisors white chalky and weaker than normal. ","Normal","C57BL/6J (inbred since 1992)","Yes","No","Yes","Yes","Yes","Yes","No","Poor","10","Extensive - colony est 1992, no new stock added since then","Male homozygous for CF with Het female","No","2012-03-16",null,0,0,null,null,"true",null,"David","Parsons","Women's and Children's Hospital, Adelaide","david.parsons@health.sa.gov.au",{"$nulls":3},"David","Parsons","david.parsons@health.sa.gov.au","AE854","Exempt ","No"]
[6859,"18YAA024a","ENU18Yaa:024a",null,"Recessive","accelerated autoimmunity and lymphoproliferation transposition","Yaa","Unknown","Tp(X;Y)1Ekw","MGI:99140",null,null,"MGI:1856277","Y",{"$nulls":15},"Yes",{"$nulls":12},"Low B cell numbers",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-03-20","Cryopreserved sperm",49,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Heather","Domaschenz","heather.domaschenz@anu.edu.au","N/A",null,"No"]
[5494,"APN 106","C57BL/6N-Socs4<tm1a(EUCOMM)Wtsi>/Marp",null,"Recessive","suppressor of cytokine signaling 4 ","Socs4","Unknown","Socs7","MGI:1914546 ","suppressor of cytokine signaling 4; targeted mutation 1a, Wellcome Trust Sanger Institute","Socs4<tm1a(EUCOMM)Wtsi>","MGI:4434370","14",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-05-02","Cryopreserved sperm",50,0,"Monash",null,"true",null,"The Australian","Phenomics Network","Monash University","leanne.cotton@monash.edu",null,"Clayton","Victoria","Leanne","Cotton","leanne.cotton@monash.edu","A2007/02","N/A","No"]
[7770,"SB 9","STOCK Gt(ROSA)26Sor<tm2(sb11)Njen> TgTn(sb-T2/Onc3)12740Njen/NciApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Nancy A Jenkins","Gt(ROSA)26Sor<tm2(sb11)Njen>","MGI:3839796","6",{"$nulls":16},"transgenic transposon concatemer 12740, Nancy A Jenkins",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",{"$nulls":3},"No","2014-10-13","Cryopreserved sperm",50,0,null,null,"false",null,"Giselle","Bellamy","Kolling Institute of Medical Research","giselle.bellamy@health.nsw.gov.au",{"$nulls":6},"1309-004A","2013-05","No"]
[6831,"APN 138","C57Bl/6N-Inpp4a<tm1a(EUCOMM)Hmgu>/MarpApb",null,"Recessive","inositol polyphosphate-4-phosphatase, type I ","Inpp4a","Unknown","107kDa ","MGI:1931123","inositol polyphosphate-4-phosphatase, type I; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Inpp4a<tm1a(EUCOMM)Hmgu> ","MGI:4434756","1",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-03-01","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS 2010/08","PC1-N09/07","No"]
[1491,"Inos-/-","B6;129-Nos2<tm1Mrl>/Apb","B6;129-Nos2<tm1Mrl>","Recessive","nitric oxide synthase 2, inducible, macrophage","Nos2","Nil","iNOS, Nos-2, NOS-II, Nos2, Nos2a","MGI:97361","targeted mutation 1, John S Mudgett","Nos2<tm1Mrl>","MGI:2158791","11",{"$nulls":15},"No",{"$nulls":12},"Abnormal artery morphology:* the large arteries of the uterus during pregnancy have thickened arterial walls and smaller lumina.Abnormal circulating estradiol level:* the cyclic changes in estradiol level are abnormal in homozygous mutant females with the peak in estradiol concentration coming later than in 129/SvEv wild-type females.Abnormal uterus morphology:* the lining of the uterus during pregnancy shows a distinct lack of cellularity in homozygous female mutants compared to wild-type females.Abnormal oestrous cycle:* diestrus length is increased in homozygous mutant females compared to 129/SvEv wild-type mice without an increase in total oestrus cycle lengthDecreased litter size:* by mid-gestation homozygous female mutants have significantly fewer viable embryos compared to wild-type females.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2007-07-03","Cryopreserved sperm",235,0,"ANU","127","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[5,"Buffy","C57BL/6JSfdAnu-Jak3<bfy>/AnuApb","C57BL/6JSfdAnu-Jak3<bfy>/AnuApb","Recessive","Janus kinase 3","Jak3","Normal",null,"MGI:99928","buffy","Jak3<bfy>","MGI:3611885","8","ENSMUSG00000031805","ENSMUST00000051995","Jak3-001","1193","1490","T to C","ENSMUSE00000329342","9","398","Leucine to Proline",{"$nulls":4},"CGCTGGCTCCCTCCCAGGCACCTACATTCTCCGCCGCAGCCCGCAGGACTATGACAGCTTT","No",{"$nulls":12},"Pan-Lymphopenia with hyperactivated CD4⁺ cellsObstructed B cell maturationReduced B cell numbers in peripheryB220⁺CD19⁺cells, IgM⁺IgD⁺ cells or CD21⁺IgD⁺ cells were reduced in the spleen by factor of 3.Peritoneal cavity: reduced IgM⁺IgD⁻ cells and only partially reduced IgM⁺IgD⁺ cell numbersReduced numbers of thymocytes at all stages of T cell maturation.Thymi are smaller than aged-matched controls.50% of CD4⁺ cells compared to controls4 fold lower levels of CD8⁺ cells compared to controlsMutation intrinsic to B and T cells, exaggerated under competitive reconstitution with wild-type cells, SCID mouse. Develop diarrhoea",null,"C57BL/6JSfdAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2005-11-28","Cryopreserved sperm",25,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[34,"Captain Morgan, ENU4AT:038 ","C57BL/6JSfdAnu-Dock8<cpm>/AnuApb","C57BL/6JSfdAnu-Dock8<cpm>/AnuApb","Recessive","dedicator of cytokinesis 8","Dock8","Nil",null,"MGI:1921396","dedicator of cytokinesis 8; captain morgan","Dock8<cpm>","MGI:3835422","19","ENSMUSG00000052085","ENSMUST00000025831","Dock8-201",{"$nulls":7},"25202202","20",null,null,"GCAGCCCATGGTCATTGCTGGCCAAACAGGTAGAGGCCTGTGGGTAGGGAGGAGGCATGG","Yes",{"$nulls":12},"Defective antibody response to immunization: failure to sustain antibody formation, undergo affinity maturation or to mount heightened recall (memory) response upon booster immunization. DOCK8-mutant B cells were unable to form marginal zone B cells or to persist in germinal centers and undergo affinity maturation. Dock8 mutations disrupted accumulation of the integrin ligand ICAM-1 in the B cell immunological synapse but did not alter other aspects of B cell antigen receptor signaling.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2004-04-20","Cryopreserved sperm",26,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Katrina","Randall","katrina.randall@anu.edu.au","J.APF.16.08","N/A","No"]
[8318,"CIB1 Knockout","B6.129S6-Cib1<tm1Prse>/Apb",null,"Recessive","calcium and integrin binding 1 (calmyrin)","Cib1","Nil","Kip","MGI:1344418","calcium and integrin binding 1 (calmyrin); targeted mutation 1, Leslie V Parise","Cib1<tm1Prse>","MGI:3690129","7",{"$nulls":28},"Female, normalDecreased testis weight:• weight of testis at 3-4 months of age is about 47.5% that of controlsAbnormal spermatogenesis:\t• spermatogonia, spematocytes, and round spermatids are present in the testis; however, seminiferous tubules lack advanced spermatids, have multinucleated spermatids near the tubule lumen and no sperm are found in the epididymis• increase in spermatid apoptosis in the testisAzoospermia:\t• sperm production is undetectable in the epididymisAbnormal spermiogenesis.• disruption of the haploid phase of germ cell differentiationarrest of spermatogenesis.• spermatogenic cells complete both mitotic and meiotic divisions, however postmeiotic spermatids do not develop normally and sperm are not producedMale infertility:\t• males are sterile due to disruption of the haploid phase of spermatogenesis","Both female and male are normal","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm",50,0,null,null,"false",null,"Stuart","Pitson","Centre for Cancer Biology, University of South Australia","stuart.pitson@unisa.edu.au",{"$nulls":8},"No"]
[51,"LeukSkywalker,  ENU3strain:004 ","B6JSfdAnu;NODAnu-Eed<lusk>/AnuApb","B6SfdAnu;NODAnu-Eed<lusk>/AnuApb","Recessive","embryonic ectoderm development","Eed","Nil","l(7)5Rn, l7Rn5","MGI:95286","LeukSkywalker","Eed<lusk>","MGI:3611895","7","ENSMUSG00000030619","ENSMUST00000107234","Eed-001",{"$nulls":7},"97120003","4",null,null,"GTTTTTATAGCCCTGGTTTAAGAAATTTGATAAGTACATCAGAACTTTGAAAACGAATTC","No",{"$nulls":12},"Dwarf, dilute coat, possible leukemia ",null,"C57BL/6JSfdAnu x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7",null,"No","2006-02-06","Cryopreserved sperm",121,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.04.06","N/A","No"]
[5931,"NesCreERT2Line4 x IDTR",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7089,"178.3","B10.BR.Cg-Tg(H2-K<b>)178.3/Apb",null,"Dominant",{"$nulls":25},"H-2Kb","H-2Kb",{"$nulls":10},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"No","2012-09-20","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":3},"Patrick","Bertolino","p.bertolino@centenary.org.au","K75/1-2012/3/5632","IBC 02-0023 / PC1 NLRD","No"]
[7567,"Alpha 2 mice","B6.129-Gabra2<tm1.1Geh>/J",null,"Recessive","gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2","Gabra2","Nil","C630048P16Rik, Gabra-2","MGI:95614","gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2; targeted mutation 1.1, Gregg E Homanics","Gabra2<tm1.1Geh>","MGI:5000434","5",{"$nulls":28},"Homozygotes are under represented at birth.  They respond differently to alcohol and anaesthetics ","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-01-15",null,0,0,null,null,"true",null,"Petra","van Nieuwenhuijzen","The University of Sydney","petra.s.van@gmail.com",{"$nulls":3},"Petra","van Nieuwenhuijzen","petra.s.van@gmail.com","l24/8-2013/3/6038",null,"No"]
[5314,"BALB.Lyn up/up ","BALB/c-Lyn<tm1Mhi>/Apb",null,"Semi-dominant","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Reduced","Lyn<up>, Lyn<Y508F>","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Margaret Hibbs","Lyn<tm1Mhi>","MGI:2157016","4",{"$nulls":15},"Yes",{"$nulls":12},"The mice carry a gene-targeted gain-of-function mutation in the Lyn tyrosine kinase (Y508F).  The mice display a severe diminution of mature B cells but have increased numbers of B1a B cells.  Their B cells display marked down-regulation of surface IgM, Ig-beta, CD19, CD21 and CD22, and they are poorly responsive to B cell receptor cross-linking. Unlike mixed genetic background Lyn<up/up> mice, BALB/c background mice are not autoimmune-prone.  Due to the dominant nature of the gain-of-function Lyn mutation, Lyn-expressing cells from Lyn<up/up> mice show hyper-phosphorylation of many signaling proteins.On the BALB/c genetic background, the mice develop a severe inflammatory lung disease that resembles bullous emphysema.  The disease is obvious in 12 wk old mice.","Lyn<+/up> mice show a reduction in numbers of B cells and Lyn-expressing cells show hyper-phosphorylation of many signaling proteins.","Balb/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2010-11-09","Cryopreserved sperm",50,0,null,null,"true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Centre for Medical Research, Royal Pde","Parkville","Victoria",{"$nulls":3},"031/08","040/2001 &304","No"]
[5491,"WWP2","WWP2",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Unknown",null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-05-02","Cryopreserved sperm",60,0,null,null,"true",null,"Sharad","Kumar","Hanson Institute","sharad.kumar@health.sa.gov.au",{"$nulls":3},"Kathryn","Mills","kathryn.mills@health.sa.gov.au","N/A","N/A","No"]
[7076,"APN159","C57BL/6N-A-Recql4<tm3(EUCOMM)Wtsi>/Marp","MGI:5050948","Recessive","RecQ protein-like 4","Recql4","Unknown",null,"MGI:1931028","RecQ protein-like 4; targeted mutation 3, Wellcome Trust Sanger Institute ","Recql4<tm3(EUCOMM)Wtsi>/Marp ","MGI:5050948","15",{"$nulls":28},"Unknown","Normal","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-09-05","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS/2010/08","PC1-N09/07","No"]
[6707,"Tie2cre","B6.Cg-Tg(Tek-cre)1Ywa/Ausb",null,"Semi-dominant",{"$nulls":26},"mouse endothelial-specific receptor tyrosine kinase promoter/enhancer",{"$nulls":10},"Reduced fertility:*Mice mated to Tg(Tek-cre)12Flv mice produce litters that exhibit high lethality.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2572","true",null,"John","Pimanda","Moss Vale","jpimanda@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[201,"TGFbRIII KO","B6;129S1-Tgfbr3<tm1Stv>/Apb","B6;129S1-Tgfbr3<tm1Stv>/Apb","Recessive","transforming growth factor, beta receptor III","Tgfbr3","Nil","betaglycan, TBRIII","MGI:104637","targeted mutation 1, Kaye Stenvers","Tgfbr3<tm1Stv>","MGI:2664514","5",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.Embryonic lethal E16.5-E18.5 of heart and liver defects",null,"C57BL/6 x 129","No","No","Yes","No","No","Yes","Yes","Unknown",{"$nulls":3},"No","2006-04-18","Cryopreserved sperm",210,0,null,null,"false",null,"Kaye","Stenvers","MIMR-PHI Institute of Medical Research","Kaye.Stenvers@princehenrys.org",{"$nulls":3},"Kaye","Stenvers","Kaye.Stenvers@princehenrys.org","N/A","N/A","No"]
[5520,"p47phox knockout","B6.129S2-Ncf1<tm1Shl>/MarpApb",null,"Recessive","neutrophil cytosolic factor 1","Ncf1","Nil","NADPH oxidase subunit (47kDa), Ncf-1, NOXO2, p47<phox>, p47phox","MGI:97283","neutrophil cytosolic factor 1; targeted mutation 1, Steven M Holland","Ncf1<tm1Shl>","MGI:1934143","5",{"$nulls":15},"No",{"$nulls":12},"Animals are immunocompromised and hence highly susceptible to bacterial infection.","Animals are immunocompromised and hence highly susceptible to bacterial infection.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-06-09","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Phil","Bird","Monash University","phil.bird@monash.edu",{"$nulls":3},"Monica","Prakash","monica.prakash@monash.edu","SOBS/B/2008/30/BC","N/A","No"]
[107,"Albert ; KLK4","C57BL/6JSfdAnu-Tg(KLK4mHEL)6Ccg/AnuApb","C57BL/6JSfdAnu-Tg(KLK4mHEL)6Ccg/AnuApb","Dominant",{"$nulls":25},"transgene insertion 6, Christopher C Goodnow","H2-K<b>","Ubiquitous",{"$nulls":9},"Express membrane bound HEL under control of H2-K<b> promoter. Transmembrane domain cloned from H2-K<b> molecule.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"21","hom x hom","No","2006-02-06","Cryopreserved sperm",122,0,"ANU","208","false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.03.06","N/A","No"]
[7092,"Mekk2 ","ENU7PMH 130 B10:B6 (no ndfip1)",null,"Recessive","mitogen-activated protein kinase kinase kinase 2","Map3k2","Unknown","9630061B06Rik, Mekk2, MEK kinase 2","MGI:1346873",{"$nulls":3},"18",{"$nulls":28},"Unknown ","Unknown","C57BL/6SfdAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","unknown","unknown","het x het","No","2012-09-21","Cryopreserved sperm",36,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","Matthew.cook@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","A2011/46",null,"No"]
[7578,"Inpp5efl","C57BL/6-Inpp5e<tm1Cmit>/Marp",null,"Dominant","inositol polyphosphate-5-phosphatase E","Inpp5e","Normal","1200002L24Rik, 72kDa, mKIAA0123","MGI:1927753",{"$nulls":3},"2",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-01-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Christina","Mitchell","Monash University","christina.mitchell@monash.edu",{"$nulls":3},"Sandra","Hakim","sandra.hakim@monash.edu","SOBSB/2009/21","PC1-N31/13","No"]
[8548,"Foz:Tlr9 KO","C57BL/6-Alms1<foz> Tlr9<tm1Aki>/AnuApb",null,"Recessive","toll-like receptor 9","Tlr9","Nil",null,"MGI:1932389","toll-like receptor 9; targeted mutation 1, Shizuo Akira","Tlr9<tm1Aki>","MGI:2660562","9",{"$nulls":58},"Vanessa","Barn","vanessa.barn@anu.edu.au"]
[319,"B6.Prf -/-","C57BL/6-Prf1<tm1Sdz>/AnuApb","C57BL/6-Prf1<tm1Sdz>/Anu","Recessive","perforin 1 (pore forming protein)","Prf1","Nil","perforin, Pfn, Pfp, Prf-1","MGI:97551","targeted mutation 1, Sandoz Pharmaceutical","Prf1<tm1Sdz>","MGI:1857235","10",{"$nulls":28},"Homozygous null mice exhibit increased susceptibility to viral infection and defective cytotoxic T cell cytolysis and NK cell cytolysis.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","19",null,null,"No","2006-05-04","Cryopreserved sperm",100,0,"ANU","018","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","A.BS.01.09","N/A","No"]
[868,"C3H.OH","C3H.OH-H2<o2>/AnuApb","C3H.OH-H2<o2>/AnuApb","Dominant","histocompatibility-2, MHC","H2","Normal","H-2","MGI:95894",{"$nulls":3},"17",{"$nulls":15},"Yes",{"$nulls":14},"C3H/HeSf x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"brother x sister","No","2007-05-25","Cryopreserved sperm",100,0,"ANU","123","true",null,"Arno","Mullbacher","The Australian National University","arno.mullbacher@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","N/A","N/A","No"]
[8547,"Foz:Ppara","C57BL/6-Alms1<foz> Ppara<em1Anu>/AnuApb",null,"Recessive","peroxisome proliferator activated receptor alpha","Ppara","Unknown","4933429D07Rik, Nr1c1, Ppar, PPARalpha, PPAR-alpha","MGI:104740",{"$nulls":3},"15",{"$nulls":58},"Vanessa","Barn","vanessa.barn@anu.edu.au"]
[8601,"ENU44:G2","ANU:ENU44:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2018-11-07","Cryopreserved sperm",1188,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[5650,"C57 x Super16TOPFLASH",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[2010,"Stat3 heterozygous knockout","B6;129P2-Stat3<tm1Aki>/Apb","B6;129P2-Stat3<tm1Aki>","Recessive","Signal transducer and activator of transcription 3","Stat3","Nil","Aprf","MGI:103038","targeted mutation 1, Shizuo Akira","Stat3<tm1Aki>","MGI:1926814","11",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic lethal (E7.5)","Viable, fertile - no apparent abnormalities.","129Sv x C57BL/6","No","No","Yes","No","No","Yes","No","Good",null,null,"heterozygous x heterozygous","No","2007-09-17","Cryopreserved sperm",115,0,"Monash",null,"false",null,"Brendan","Jenkins","Monash University","brendan.jenkins@med.monash.edu.au",{"$nulls":3},"Brendan","Jenkins","brendan.jenkins@med.monash.edu.au","N/A","N/A","No"]
[5178,"ENU18FOX:008 B6.129-Tg(FoxP3-GFP)","B6.129-Dclre1c<m1Anu> Foxp3<tm2Ayr>/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X",{"$nulls":58},"Anusha","Subramaniam","anusha.subramaniam@anu.edu.au","J.APF.19.08","N/A"]
[8543,"CREB-lox","B6.129-Creb1<tm3Gsc>/GscApb",null,"Recessive","cAMP responsive element binding protein 1","Creb1",null,"2310001E10Rik, 3526402H21Rik, Creb, Creb-1","MGI:88494","cAMP responsive element binding protein 1; targeted mutation 3, Gunther Schutz","Creb1<tm3Gsc>","MGI:2181395","1",{"$nulls":28},"Normal phenotype until crossed with a Cre-transgenic mouse","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-08-03","Cryopreserved sperm",50,0,null,null,"false",null,"Theo","Mantamadiotis","University of Melbourne","theom@unimelb.edu.au",{"$nulls":8},"No"]
[5106,"Tesk2 KO","C57BL/6-Tesk2<KO>/MarpApb",null,"Recessive","testis-specific kinase 2","Tesk2","Unknown",null,"MGI:2385204",{"$nulls":3},"4",{"$nulls":15},"Yes",{"$nulls":12},"No apparent phenotype. (No significant differences in weights of i) whole body, testis, reproductive tract, spleen, liver, pancreas, kidney, heart, lungs)","No apparent phenotype. (No significant differences in weights of i) whole body, testis, reproductive tract, spleen, liver, pancreas, kidney, heart, lungs)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-04-30","Cryopreserved sperm",63,0,"Monash",null,"false",null,"Peter","Stanton","MIMR-PHI Institute of Medical Research","Peter.stanton@princehenrys.org",{"$nulls":3},"Peter","Stanton","Peter.stanton@princehenrys.org","MMCB 2007/17","E21/07","No"]
[8551,"Ddit3 tm1c","C57BL/6N-Ddit3<tm1c(EUCOMM)Hmgu>",null,"Recessive","DNA-damage inducible transcript 3","Ddit3",null,"C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153","MGI:109247","DNA-damage inducible transcript 3; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Ddit3<tm1c(EUCOMM)Hmgu>","MGI:5520283","10",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal",null,"C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-08-16","Cryopreserved sperm",12,0,null,null,"false",null,"Doug","Taupin","The Canberra Hospital","doug.taupin@act.gov.au",{"$nulls":3},"Ayumi","Hosaka","Ayumi.Hosaka@act.gov.au",null,null,"No"]
[6580,"GPR43?","B6.Cg-Ffar2<tm1Dgen>/CrlAusb",null,"Dominant","free fatty acid receptor 2","Ffar2","Normal","Gpr43","MGI:2441731","free fatty acid receptor 2; targeted mutation 1, Deltagen","Ffar2<tm1Dgen>","MGI:4367910","7",{"$nulls":28},"Increased sensitivity to xenobiotic induced morbidity/mortality:*In DSS-treated mice.Increased susceptibility to induced colitis:*During the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice.*Mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice.*TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice.*Transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice.Increased T cell number:*CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice.Abnormal granulocyte physiology:*Granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells.      Abnormal neutrophil physiology:      *Neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice.      *Neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells.      *Recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice.         Impaired neutrophil chemotaxis:         *Neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice.         Impaired neutrophil phagocytosis:         *Neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice.Increased susceptibility to induced arthritis:*While mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice.Lung inflammation:*Mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice.",null,"Mixed - mice","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","610","true",null,"David","Zahra","Garvan Institute","d.zahra@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[4877,"B6.B-cell deficient/Gal KO","C57BL/6-Igh-6<tm1Cgn> Ggta<tm1>/Apb",null,"Recessive","glycoprotein galactosyltransferase alpha 1, 3","Ggta1","Nil","alpha Gal, alpha3GalT, Gal, GALT, Ggta, Ggta-1, glycoprotein alpha galactosyl transferase 1","MGI:95704",{"$nulls":3},"2",{"$nulls":58},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML 43","94"]
[4882,null,"C.B6-Socs1<tm3wehi> Tg(Lck-cre)I57Jxm/Apb",null,"Recessive","suppressor of cytokine signaling 1","socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research","Socs1<tm3Wehi>","MGI:2656917","16",{"$nulls":15},"Yes","transgene insertion I57, Jamey Marth","lymphocyte protein tyrosine kinase (Lck)",{"$nulls":10},"Enhanced differentiation of thymocytes toward CD8+ T cells. Thymus hyperplasia.Enlarged lymph nodes",null,"BALB/c","Yes","No","Yes","Yes","No","Yes","No","Poor","10","2",null,"No","2009-09-28","Cryopreserved sperm",20,0,"St V","078?","false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":6},"43/08, BGMML#3","96, 73, #1228/2003","No"]
[2369,"Tilcara ; ENU6WT:121","C57BL/6JSfdAnu-Prkcb<tilc>/AnuApb","C57BL/6JSfdAnu-Prkcb<tilc>/AnuApb","Semi-dominant","protein kinase C, beta 1","Prkcb1","Unknown","PKC-Beta, Pkcb, Prkcb2","MGI:97596","tilcara","Prkcb<tilc>","MGI:4819152","7","ENSMUSG00000052889","ENSMUST00000064989","Prkcb-001","1654","1874","T to C","ENSMUSE00000439236","15","552","Serine to Proline",{"$nulls":4},"AAGGGGAGGATGAGGATGAACTCTTCCAGTCAATCATGGAACACAATGTGGCGTATCCCAA","Yes",{"$nulls":12},"Defective T-cell independent type 2 antibody response to NP-Ficoll.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",56,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[5566,"ENU20Bcl2.05 VavP-BCL2-69; C57BL/6-Tg(Vav-BCL2)1Jad/Wehi","B6(Cg)-Nin<m1Anu> Tg(Vav-BCL2)1Jad/WehiAnuApb",null,"Dominant","ninein","Nin",null,"3110068G20Rik, mKIAA1565","MGI:105108",{"$nulls":3},"12","ENSMUSG00000021068","ENSMUST00000085314","Nin-001","1240","1240","A to G","ENSMUSE00000114325","9","414","Asparagine to Glycine",{"$nulls":4},"TGGACGATCACCACGCGGCCATTGAGCGGAGGAATGAATACAACCTCAGGAAACTGGATGA",null,"transgene insertion 1, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":9},"Increased numbers of Monocytes and Granulocytes in peripheral blood","Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-08-19","Cryopreserved sperm",12,0,"ANU",null,"true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","N/A","N/A","No"]
[7582,"B1-8 High Affinity +/-, (ROSA)td Tomato -/- KI","B6.129-IgH<tm1Mnz> Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>/JMnzAnu",null,"Recessive","immunoglobulin heavy chain complex","Igh",null,null,"MGI:96442","immunoglobulin heavy chain complex; targeted mutation 1, Michel C Nussenzweig","Igh<tm1Mnz>","MGI:3712224","12",{"$nulls":28},"All cells express red colour from Tomato",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Tomato - 8x to B6; B1-8 high >15x to B6",null,null,"No","2014-02-05","Cryopreserved sperm",10,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7582,"B1-8 High Affinity +/-, (ROSA)td Tomato -/- KI","B6.129-IgH<tm1Mnz> Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>/JMnzAnu",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26 ","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Hongkui Zeng","Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>","MGI:3809523","6",{"$nulls":61},"N/A","N/A"]
[3689,"Rose ; ENU11B6:058b","C57BL/6JAnu-Tap1<rose>/AnuApb","C57BL/6JAnu-Tap1<rose>/AnuApb","Recessive","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","Tap1","Unknown","Abcb2, Ham-1, Ham1, MTP1, PSF-1, RING4, TAP, Tap-1","MGI:98483","Rose","Tap1<rose>","MGI:3797750","17","ENSMUSG00000037321","ENSMUST00000041633","Tap1-201","1928","2074","A to T","ENSMUSE00000296635","10","643","Aspartic acid to Valine",{"$nulls":4},"GATCCGGAAGCCACTCCTGCTTATCTTGGATGATGCCACCAGTGCCCTGGATGCTGGCAAC","No",{"$nulls":12},"Very low CD8<+> T cell numbers.Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.",null,"C57BL/6jAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"4","affected x B6","No","2008-08-26","Cryopreserved sperm",100,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","J.APF.14.08","N/A","No"]
[7370,"ENU25:011:Zmym2:B6:G5","C57BL/6NCrlAnu-Zmym2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Zmym2<m1Anu>/AnuApb","Recessive","zinc finger, MYM-type 2","Zmym2","Unknown","FIM, MGC:51607, MYM, RAMP, SCLL, Zfp198","MGI:1923257","zinc finger, MYM-type 2, mutation 1, The Australian National University","Zmym2<m1Anu>","MGI:5648435","14","ENSMUSG00000021945","ENSMUST00000022511","Zmym2-201","3774","3847","T to A","ENSMUSE00000122336","22","1258","Cysteine to STOP",{"$nulls":4},"AATCCTTTAACAATGGAAAATAAAGCATGTCTTCGCTATCAGGTGTCTTCCTTATGTGGAA",{"$nulls":13},"No homozygous animals born. Presume embryonic lethal","Normal","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"5",null,"No","2013-07-05","Cryopreserved sperm",46,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au","N/A",null,"No"]
[6848,"ENU24FoxRag G1","ENu24FoxRag:G1",null,"Dominant","forkhead box P3","Foxp3","Nil","JM2, scurfin","MGI:1891436","forkhead box P3; targeted mutation 1.1, Alexander Y Rudensky","Foxp3<tm1.1Ayr>","MGI:2654936","X",{"$nulls":58},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","APF2011/41","10.2"]
[6848,"ENU24FoxRag G1","ENu24FoxRag:G1",null,"Dominant","recombination activating gene 1","Rag1","Unknown","Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":58},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","APF2011/41","10.2"]
[8607,"DMP1Cre.Socs3","B6-Socs3<tm2Wsa> Tg(Dmp1-cre)1Jqfe/StVApb",null,"Recessive","suppressor of cytokine signaling 3","Socs3","Unknown","CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3","MGI:1201791","suppressor of cytokine signaling 3; targeted mutation 2, Warren S Alexander","Socs3<tm2Wsa>","MGI:2663917","11",{"$nulls":16},"transgene insertion 1, Jian Q Feng","Dmp1","odontoblast-specific expression",{"$nulls":9},"We have assessed the bone phenotype of the osteocyte-specific SOCS3 null mouse, and have found that they have significant sex-specific changes in bone mass.","Normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2018-11-20","Cryopreserved sperm",40,0,"St V",null,"false",null,"Narelle","McGregor","St Vincent's Institue","nmcgregor@svi.edu.au",{"$nulls":8},"No"]
[1541,"Kapil Dev","C57BL/6-Gzma<tm1Simn> Prf1<tm1Sdz> Tg(TcraTcrb)1100Mjb/AnuApb",null,"Recessive","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"Yes","transgene insertion 1100, Michael J Bevan",null,"High - 49 Copies",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-06","Cryopreserved sperm",30,0,"ANU","007","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6224,"B6del535/bakM","B6del535/C57BL/6/Bak knockout ",{"$nulls":3},"   bok       bak    ",{"$nulls":35},"Bak - Homozygous females may have occluded vaginal opening. ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2853","true",null,"Andreas","Strasser",{"$nulls":8},"N/A","N/A","No"]
[5549,"Tg5C2 ; Eales","C.CBA-Tg(CD2-IL5)5C2Ldt/AnuApb","C.CBA-Tg(CD2-IL5)5C2Ldt/AnuApb","Dominant",{"$nulls":25},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia.    Northern blotanalysis identified 11,5 mRNA in the thymus, Peyer's patches, and subcutaneous (pooled inguinal and axillary) lymph nodes. No IL5 mRNA was detected in liver, heart, brain, or skeletal muscle tissues from transgenics, nor in any tissues from normal littermates.   Do not maintain as homozygotes.  While this is apparently possible, survival of homozygotes likely to be lower.","Appear normal with peripheral blood eosinophilia and increased numbers of eosinophils in the spleen (with splenomegaly), bone marrow.  Heterozygous BALB/c and C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","BALB/c","No","No","Yes","No","No","Yes","No","Excellent","20",null,"Transgenic male with wild type female","No","2011-08-08","Cryopreserved sperm",50,0,"ANU","077","false",null,"Paul","Foster","The University of Newcastle","paul.foster@newcastle.edu.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A","N/A","No"]
[7586,"ADAR3+/-","C57BL/6-Adarb2<tm1.1>/StvApb",null,"Dominant","adenosine deaminase, RNA-specific, B2","Adarb2 ","Nil","Adar3, RED2 ","MGI:2151118","Adar3","Adar3+/-",null,"13",{"$nulls":28},"Normal as far as investigator / depositor of strain can tell.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","4",null,"+/- to +/- (can breed -/- to -/- happily also)","No","2014-02-14","Cryopreserved sperm",30,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC022/12","IBC166","No"]
[7587,"Adar3 LacZ","C57BL/6N-Adarb2<tm1a(KOMP)Mbp>/MarpStvApb",null,"Dominant","adenosine deaminase, RNA-specific, B2","Adarb2","Reduced","Adar3, RED2","MGI:2151118","adenosine deaminase, RNA-specific, B2; targeted mutation 1a, Mouse Biology Program, UCDavis","Adarb2<tm1a(KOMP)Mbp>","MGI:4944293","13",{"$nulls":28},"none apparent","none apparent","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","generated on a C57bl6 background",null,"ki/+ to KI/+ or WT female","No","2014-02-14","Cryopreserved sperm",50,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC022/12","IBC166","No"]
[5125,"BALB-ANU\"X\".A2G-Mx1 (Mx1+/+)","BALB/c.A2G-Mx1<r>/AnuApb",null,"Dominant","myxovirus (influenza virus) resistance 1","Mx1","Normal","Mx, Mx-1, myxovirus (influenza) resistance 1 polypeptide","MGI:97243","myxovirus (influenza virus) resistance 1; myxovirus resistance","Mx1<r>","MGI:3715151","16",{"$nulls":28},"Normal, i.e. highly influenza resistant.","Normal.","BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-05-19",null,0,0,"ANU","424","true",null,"Klaus","Matthaei","The Australian National University","klaus.matthaei@anu.edu.au",{"$nulls":3},"Michael","Frese","michael.frese@canberra.edu.au","J.MB.33.07","ANU ID 8.14 and ANU ID 3.11","No"]
[4874,"B6.Myd88.KO","C57BL/6-Myd88<tm1Aki>/StVApb",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","targeted mutation 1, Shizuo Akira","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":15},"Yes",{"$nulls":12},"Increased apoptosis: 5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells.Abnormal response/metabolism to xenobiotics: knockout mice are more susceptible to bleomycin-induced lung injury.Abnormal dendritic cell morphology/development: increased numbers of dendritic cells in brains of mice infected with Plasmodium.Abnormal T cell physiology: induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonists, was severely impaired.Abnormal macrophage physiology:* TNF production is impaired in thioglycollate-elicited macrophages treated with intact zymosan.* cytokine production by macrophages cultured with P. carinii cysts is reduced compared to wild type.Abnormal dendritic cell physiology: cytokine secretion elicited by zymosan or LPS is impaired.Abnormal inflammatory mediator physiology.Abnormal chemokine physiology: hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice.Abnormal cytokine physiology: CpG-A or RNA polyuridylic acid induced production of interferon-alpha was abolished in plasmacytoid dendritic cells.Abnormal TNF physiology: less upregulation of TNF-alpha in Plasmodium infection.Abnormal cytokine secretion:* LPS-induced cytokine production by BMDCs is almost abolished compared to controls and Myd88-sufficient mutants.* after stimulation with zymosan, TNF and Il12 production are significantly reduced in Myd88-deficient animals.Abnormal interferon physiology: less up regulation of INF-gamma in Plasmodium infection.Abnormal interleukin physiology: less upregulation of IL-12b in Plasmodium infection.Altered susceptibility to infection:* decreased susceptibility to parasitic infection.* resistant to cerebral malaria but eventually die of extremely high parasitemia.Increased susceptibility to viral infection: increased susceptibility to encephalomyocarditis virus (EMCV) infection compared to wildtype.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-28","Cryopreserved sperm",80,0,"St V","040","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML 35","94","No"]
[5115,"ENU14Yaa:016a","B6.Cg-Btk<m1Anu> Yaa/AnuApb","B6.Cg-Btk<m1Anu> Yaa/AnuApb","Recessive","Bruton agammaglobulinemia tyrosine kinase","Btk","Unknown","Bruton's tyrosine kinase, X-linked immune deficiency, xid","MGI:88216","Bruton agammaglobulinemia tyrosine kinase; mutation 1, The Australian National University","Btk<m1Anu>","MGI:5563504","X","ENSMUSG00000031264","ENSMUST00000033617","Btk-001",{"$nulls":7},"131089223","11",null,null,"GTGTCTGTGTTTGCTAAATCTACTGGGTACGTGTTATGGTTCCAGTGATATGGGGTTAAA","Yes",{"$nulls":12},"Low B cell numbers in peripheral blood.While mice carry Yaa allele the phenotype does not appear to be dependent upon Yaa.",null,"C57BL/6JAnu x B6.SB-Yaa","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-05-11","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","J.APF.16.08","N/A","No"]
[7591,"R26-CreER Recql4fl/fl pRbfl/fl","C57BL/6-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Recql4<tm2272Arte> Trp53<tm1Brn>/StvApb",null,"Dominant","RecQ protein-like 4","Recql4","Reduced","RECQ4 ","MGI:1931028 ","Recql4<tm2272Arte>","Recql4fl/fl",null,"15",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC044/10","IBC166"]
[7590,"R26-CreER p53fl/fl pRbfl/fl","C57BL/6-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Rb1<tm3Tyj> Trp53<tm1Brn>/StvApb",null,"Dominant","retinoblastoma 1","Rb1","Nil","pRb, Rb, Rb-1","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC044/10","IBC166"]
[6194,"E�Myc/565foxo","B6. E�-myc 292-1/565foxo",{"$nulls":3},"   Myc       565    ",{"$nulls":35},"Animals develop high incidence pre-B and B lymphoma - Adult mortality: 80%  Display excess pre-B cells in bone marrow, and develop lymphoma around 3 months of age. All Emu-myc mice will be visually checked twice a week from 4 weeks of age with particular attention paid to evidence of lymph node enlargement or general signs of ill health. Additionally, commencing at four weeks of age, transgenic animals will be examined once a week for swollen lymph nodes by gentle palpation of lymph node sites (axillary and inguinal regions). Mice with moderately enlarged lymph nodes indicating early lymphoma are usually otherwise healthy and normal. This is the appropriate point in disease progression for therapeutic/experimental intervention (e.g. doxycycline treatment), as lymphoma responses can be readily monitored by changes in lymph node size. Disease progression resulting in visually obvious lymph nodes, presence of ruffled fur, restricted movement, loss of weight, difficulty in breathing or obvious signs of distress will prompt euthanasia. Lymphoma tissue and other organs will be harvested post-euthanasia. ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3982","true",null,"Andreas","Strasser",{"$nulls":8},"N/A","N/A","No"]
[6196,"EμMyc/Fox03","B6.Cg-Foxo3<tm1Nmt> Tg(IghMyc)22Bri/Wehi",null,"Recessive","forkhead box O3","Foxo3",null,"1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a","MGI:1890081","forkhead box O3; targeted mutation 1, Noboru Motoyama","Foxo3<tm1Nmt>","MGI:3719789","10",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Igh (E mu) enhancer and Myc promoter","B cell lineage",{"$nulls":9},"Excess pre-B cells in bone marrow.  Animals develop high incidence pre-B and B lymphoma - Adult mortality: 80%   EμMyc/Fox03 T/+ -/- may have acceleration of tumour onset.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2914","true",null,"Suzanne","Cory","Walter and Eliza Hall Institute of Medical Research","cory@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6197,"EμMyc/Fox03/CHOP","B6.Cg-Ddit<tm1Mori> Foxo3<tm1Nmt> Tg(IghMyc)22Bri/Wehi",null,"Recessive","forkhead box O3","Foxo3","Unknown","1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a","MGI:1890081","forkhead box O3; targeted mutation 1, Noboru Motoyama","Foxo3<tm1Nmt>","MGI:3719789","10",{"$nulls":61},"N/A","N/A"]
[6207,"B6/Moz3/Bmi","B6;129-Bmi1<tm1Brn> Myst3<tm1Avo>",null,"Recessive","Bmi1 polycomb ring finger oncogene","Bmi1","Normal","Bmi-1, Bmi1, Pcgf4","MGI:88174","Bmi1 polycomb ring finger oncogene; targeted mutation 1, Anton Berns","Bmi1<tm1Brn>","MGI:1857632","2",{"$nulls":30},"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2707","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6207,"B6/Moz3/Bmi","B6;129-Bmi1<tm1Brn> Myst3<tm1Avo>",null,"Recessive","MYST histone acetyltransferase (monocytic leukemia) 3","Myst3","Nil","9930021N24Rik, KAT6A, MOZ, Zfp220","MGI:2442415","MYST histone acetyltransferase (monocytic leukemia) 3; targeted mutation 1, Anne K Voss","Myst3<tm1Avo>","MGI:3626344","8",{"$nulls":61},"N/A","N/A"]
[6217,"339/OT-1","B6.129S1-Bcl2l11<tm1Ast> Tg(TcraTcrb)1100Mjb",null,"Semi-dominant","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Nil","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser ","Bcl2l11<tm1Ast>","MGI:2156494","2",{"$nulls":16},"transgene insertion 1100, Michael J Bevan",{"$nulls":11},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3087","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6229,"Bak/Bmf","B6.129-Bak1<tm1Thsn> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor ","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":61},"N/A","N/A"]
[6226,"B6NFKB2/lpr","B6NFKB2/B6.MRL-Fas<lpr>/J COPY",null,"Recessive",null,"  NFKB2    Faslpr   ",{"$nulls":6},"Unknown",{"$nulls":28},"Mice homozygous for the lymphoproliferation spontaneous mutation (Faslpr) show systemic autoimmunity, massive lymphadenopathy associated with proliferation of aberrant T cells, arthritis, and immune complex glomerulonephrosis. Onset and severity of symptoms is dependent on genetic background, with the original MRL/MpJ background being most severely affected beginning about 8 weeks of age. Females die at an average age of 17 weeks of age and males at 22 weeks. This mouse is a model for systemic lupus erythematosus-like autoimmune syndromes.  ",null,"C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3013","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6220,"B6del478/NFKB2","B6del478/NFKB2",{"$nulls":3},"  FasL      NFKB2   ",{"$nulls":35},"B6del478 - KI/KI develop enlarged lymphnodes and spleen. Not tumour at this stage. Mice at 10-12 months of age may develop lukaemia. T cell large granulocytic lukaemia.  May have autoimmune disease.  B6del478/NFKB2 - unknown.",null,"C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2543","true",null,"Lorraine","O'Reilly",{"$nulls":8},"N/A","N/A","No"]
[6237,"Bcl-2ko/myc","B6.129-Bcl2<tm1Sjk> Tg(IghMyc)22Bri",null,"Semi-dominant","B-cell leukemia/lymphoma 2","Bcl2","Nil","Bcl-2, C430015F12Rik, D830018M01Rik","MGI:88138","B-cell leukemia/lymphoma 2; targeted mutation 1, Stanley J Korsmeyer","Bcl2<tm1Sjk>","MGI:1857134","1",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Myc promoter",{"$nulls":12},"C57BL/6 129/SV","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","416","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6240,"Blimp424/CD3","C57BL/6-Cd3e<tm1Mal> Prdm1<tm1Nutt>",null,"Semi-dominant","PR domain containing 1, with ZNF domain","Prdm1","Normal","Blimp-1, Blimp1, PRDI-BF1 ","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt","Prdm1<tm1Nutt>","MGI:3510704","10",{"$nulls":61},"N/A","N/A"]
[6246,"SCID/Arc","CB17-Prkdc<scid>",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":28},"Premature death:*Lifespan is shortened in conventional housing, however, in an SPF environment homozygotes can live to more than one year.Immune system phenotype:*In contrast to homozygotes on the NOD background, spleen cell suspensions from homozygous CB17 mice exhibit NK cell activity.      Salivary gland inflammation:      *In mice injected i.p. with cells from submandibular gland tissue of diseased Fas<lpr> mice, inflammatory lesions are observed in salivary and lacrimal glands.      *Infiltrating cells are CD4<+> and Vbeta8<+> with a minority being CD4<+> and Vbeta6<+>.      *Mice injected with cells pretreated with anti-CD4 or anti-Vbeta8 do not develop inflammatory lesions or only minor lesions are seen in parotid, submandibular, sublingual and lacrimal glands in majority of transplanted mice.      Decreased leukocyte cell number:      *Homozygotes are leukopenic.         Absent B cells:         *B cells cannot be detected in the spleen with Ig or Lyb-8 (Cd22) markers.            Absent pre-B cells:            *Pre-B cells cannot be detected in the bone marrow.      Decreased B cell proliferation:      *Spleen cells do not proliferate in response to LPS.      Decreased T cell proliferation:      *Splenic T cells do not proliferate in response to concanavalin A or to a one-way mixed lymphocyte reaction.      Abnormal spleen white pulp morphology:      *Splenic follicles are devoid of lymphocytic cells.      Abnormal thymus morphology:      *The remaining thymocytes that express the Thy1 marker are larger than normal thymocytes.         Abnormal thymus cortex morphology:         *Lymphocytic cortex is not evident in thymus.         *Mucinous cysts are occasionally found.         Small thymus:         *1/10th to 1/100th normal size.      Absent Peyer's patches:      *Peyer?s patches are rarely visible.      Lymph node hypoplasia:      *Lymph nodes have only a few lymphoid cells, however, sinuses are well-formed and contain macrophages.      Small lymphoid organs         Lymphoid hypoplasia:         *Lymphid organs are 1/10th or less of normal size.         *Lymph organs consist mostly of supportive tissue with varying numbers of fibroblasts, macrophages and histiocytes.      Abnormal humoral immune response:      *Mice are unable to produce specific antibody to two T-independent antigens.         Decreased immunoglobulin level:         *31/206 mice tested have low levels of serum immunoglobulin, all 31 have an IgG isotype and of these, 17 also have an IgM isotype.         *The remaining 175/206 mice do not have detectable serum immunoglobulin.         *Only 1/11 homozygotescan produce greater than 1 ug/ml serum Ig at up to 100 days of age, however, 21/29 homozygotes produce greater than 1 ug/ml between 100-200 days of age.            Decreased IgG level:            *Hypogammaglobulinemic.      Abnormal response to transplant:      *Following injection of human T lymphoblastoid cells, 40% of nucleated spleen cells are of human origin by 4 weeks post injection.         Increased length of allograft survival:         *Homozygotes do not reject full thickness skin allografts.         *1/5 homozygotes (5-6 weeks of age) reject orthotopic tail skin allografts throughout a 3 month observation period.Hematopoietic system phenotype:*In contrast to homozygotes on the NOD background, homozygous CB17 mice exhibit normal erythrocyte mean cell volumes.T cell derived lymphoma:*Spontaneous T cell lymphomas are found in greater than 10% of homozygotes at 5-9 months of age.*Tumors arise in the thymus and are highly invasive and are transplantable.Thymic lymphoma",null,"CB17","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1453","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6244,"Bmf/473/Bax","B6.129-Bax<tm1Sjk> Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857134","7",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2878","true",null,"Philippe","Bouillet","Walter and Eliza Hall Institute of Medical Research","bouillet@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6243,"Bmf/473/Bak ","B6.129-Bak1<tm1Thsn> Bcl2l11<tm2.1Boui> Bmf<tm1Rjd>",null,"Recessive","BCL2-like 11 (apoptosis facilitator)","Bcl2l11","Normal","1500006F24Rik, Bim, Bod","MGI:1197519","BCL2-like 11 (apoptosis facilitator); targeted mutation 2.1, Philippe Bouillet","Bcl2l11<tm2.1Boui>","MGI:4366751","2",{"$nulls":61},"N/A","N/A"]
[6253,"B6/TLR4 x DEC-205 ","B6.129P-Ly75<tm1Mnz> Tlr4<Lps-d>/J ",null,"Recessive","lymphocyte antigen 75","Ly75","Nil","CD205, DEC-205","MGI:106662","lymphocyte antigen 75; targeted mutation 1, Michel C Nussenzweig","Ly75<tm1Mnz>","MGI:3575119","2",{"$nulls":30},"C3H/He & C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","4281","true",null,"Jose","Villadangos","Walter and Eliza Hall Institute of Medical Research","villadangos@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6252,"PLT4/GFP","C57BL/6-Mpl<tm1Wsa> Myb<Plt4> Tg(UBC-GFP)30Scha/JWehi",null,"Semi-dominant","myeloproliferative leukemia virus oncogene","Mpl","Nil","c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, thrombopoietin receptor, TPO-R","MGI:97076","myeloproliferative leukemia virus oncogene; targeted mutation 1, Warren S Alexander","Mpl<tm1Wsa>","MGI:2660811","4",{"$nulls":16},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3379","true",null,"Ken","Shortman","Walter and Eliza Hall Institute of Medical Research","shortman@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6252,"PLT4/GFP","C57BL/6-Mpl<tm1Wsa> Myb<Plt4> Tg(UBC-GFP)30Scha/JWehi",null,"Semi-dominant","myeloblastosis oncogene","Myb","Normal","c-myb","MGI:97249","myeloblastosis oncogene; Plt4 ","Myb<Plt4>","MGI:3045843","10",{"$nulls":61},"N/A","N/A"]
[6265,"del376/266","B6.129S-Bcl2l11<tm1Ast> Bmf<tm1Rjd>",null,"Recessive","BCL2 modifying factor","Bmf","Nil",null,"MGI:2176433","BCL2 modifying factor; targeted mutation 1, Roger J Davis","Bmf<tm1Rjd>","MGI:4421178","2",{"$nulls":61},"N/A","N/A"]
[6266,"Puma/p21","B6.129S-Bbc3<tm1Ast> Cdkn1a<tm1Tyj>",null,"Recessive","cyclin-dependent kinase inhibitor 1A (P21)","Cdkn1a","Nil","CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21<WAF1/CIP1>, p21Cip1, p21WAF, SDI1, Waf1 ","MGI:104556","cyclin-dependent kinase inhibitor 1A (P21); targeted mutation 1, Tyler Jacks","Cdkn1a<tm1Tyj>","MGI:1933751","17",{"$nulls":61},"N/A","N/A"]
[6272,"ERTF5-rttA-GFP","ERTF5-rttA3-IRES-GFP",{"$nulls":3}," ERTF5tA  ",{"$nulls":35},"Phenotype does not differ from a wildtype of the same genetic background.",null,"FVB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3541","true",null,"Jane","Visvader",{"$nulls":8},"N/A","N/A","No"]
[6273,"B6bcl 22","C57BL/6-Tg(BCL2)22Wehi",null,"Semi-dominant",{"$nulls":25},"transgene insertion 22, Walter and Eliza Hall Institute of Medical Research","SV40 promoter",{"$nulls":10},"Increased B cell number",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","47","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6275,"Myc/Puma/Noxa","B6.SJL-Bbc3<tm1Ast> Pmaip1<tm1Ast> Tg(IghMyc)22Bri",null,"Semi-dominant","BCL2 binding component 3","Bbc3","Nil","PUMA","MGI:2181667","BCL2 binding component 3; targeted mutation 1, Andreas Strasser","Bbc3<tm1Ast>","MGI:2681654","7",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Myc promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1621","true",null,"Clare","Scott","Walter and Eliza Hall Institute of Medical Research","scottc@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6278,"E�Myc/Mcl1-1(33)/bim","E�Myc/vavMcl-1(33)/bim",{"$nulls":3},"   Myc      Mcl-1      bim    ",{"$nulls":35},"E�-Myc transgenics succumb to lymphoma from 3-12 months of age. We expect double heterozugous mice to succumb to lymphoma earlier, perhaps around 6 weeks of age. They may have large spleens and lymph nodes.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2075","true",null,"Suzanne","Cory",{"$nulls":8},"N/A","N/A","No"]
[6286,"ID4/Tet GFP","ID4-rttA3-GFP/TRE GFP shLuc",{"$nulls":3}," ID4rtta   TetGFP   ",{"$nulls":35},"No special monitoring required  This stain should not have any obvious phenotype without or with treatment of doxycycline",null,"FVB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3614","true",null,"Jane","Visvader",{"$nulls":8},"N/A","N/A","No"]
[6284,"B6Flpe","C57BL/6-Tg(ACTFLPe)9205Dym",null,"Dominant",{"$nulls":25},"transgene insertion 9205, Susan Dymecki","human ACTB promoter",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","130","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6289,"K/BxN","B6.NOD-Tg(TcraR28,TcrbR28)KRNDim",null,"Semi-dominant",{"$nulls":25},"transgene insertion KRN, Diane Mathis","natural TCR alpha and -beta promoter/enhancer elements",{"$nulls":10},"Abnormal lymphocyte cell number      Increased B cell number:      *Spleen and lymph node B cell numbers are increased 1.75-fold in mice suffering from arthritis.      Decreased CD4-positive T cell number:      *CD4+ T cells are virtually absent in the spleens of mice under 2 weeks of age.      *CD4+ T cell numbers are reduced by 3.1-fold in the spleens of adult mice.      Decreased CD8-positive T cell number:      *CD8+ T cells numbers are reduced in mice under 3 weeks of age.Abnormal T cell activation:*A greater proportion of T cells express late activation markers (CD44<hi> CD62L<lo>, CD45RB<lo>) than in transgene negative controls.      Abnormal T cell proliferation:      *T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2<g7> locus in the absence of any antigen.Abnormal T cell clonal deletion:*Clonal deletion is evident in the thymus of neonatal mice with reduced numbers of total cells and aberrant percentages of single-positive populations.*Single-positive populations normalize by 4 weeks of age though total cell numbers are still reduced.*Clonal deletion affects T cell populations in the periphery with a paucity of single-positive T cells in young mice and chronically reduced CD4<+> population in adults.Enlarged spleen:*Splenomegaly is often observed.Increased IgG1 level:*Serum IgG1 levels are dramatically increased.Abnormal macrophage recruitment:*Macrophage cells make up a large number of cells found in inflamed joints.Impaired neutrophil recruitment:*Neutrophils make up a large number of cells found in inflamed joints.Abnormal T cell anergy:*Background Sensitivity: transgenic T cells from mice on a NOD background have lower levels of T cell receptor expressed.*Background Sensitivity: transgenic T cells from mice on a NOD background have a severe reduction in response to its cognate antigen (RNAse peptide) presented by A<k> than do transgenic T cells from a C57BL/6 background.*Hybridomas created from these T cells respond normally to antigen suggesting a cell intrinsic anergy.Rheumatoid arthritis:*Background Sensitivity: transgenic mice crossed to a NOD background develop rheumatoid arthritis.*Distal paws become red and swollen.*All transgenic mice have significantly swollen ankles by 30 days of age with the degree of swelling symmetrical on either limb.*As mice age hyperextension of the ankle, valgus deviation of the knee and hyperpronation of the toes occur.*Arthritis occurs in almost all joints with the exception of hip joints.*Arthritis starts as fibrinoid material and a few cells are found in the articular cavity; edema sets in under the synovial lining, accompanied by neovascularithezation and some infiltration of inflammatory cells.*After a few weeks, disease is marked by extensive synovitis, affecting all areas of the joint with massive infiltration of inflammatory cells and beginnings of fibrosis.*After several months, the inflammation recedes leaving massive fibrosis, very little cartilage, and irregular shaped bone.Abnormal phalanx morphology:*Bones are eroded from arthritis with anarchic reconstruction occurring afterwards.Clinodactyly:*Rheumatoid arthritis leads to hyperpronation of the toes.Abnormal metatarsal bone morphology:*Bones are eroded from arthritis with anarchic reconstruction occurring afterwards.Abnormal intervertebral disk morphology:*Intervertebral inflammation occurs sporadically in these mice.",null,"C57BL/6 x NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1632","true",null,"Ian","Wicks","Walter and Eliza Hall Institute of Medical Research","wicks@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6295,"Mcl-1 flox/CD19cre/E�-myc","Mcl-1 flox/CD19cre x Mcl-1 flox/E�-myc",{"$nulls":3},"  Mcl-1    CD19cre   E�-myc   ",{"$nulls":35},"Lymphoma Development at around 80 days for T/+ myc mice.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2138","true",null,"Andreas","Strasser",{"$nulls":8},"N/A","N/A","No"]
[6300,"Mcl-1flox/Bcl-xflox","C57BL/6-Bcl2l1<tm1Mam> Mcl1<tm3Sjk>",null,"Recessive","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX","MGI:88139","BCL2-like 1; targeted mutation 1, Lothar Hennighausen","Bcl2l1<tm1Mam>","MGI:2176699","2",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2252","true",null,"Philippe","Bouillet","Walter and Eliza Hall Institute of Medical Research","bouillet@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6300,"Mcl-1flox/Bcl-xflox","C57BL/6-Bcl2l1<tm1Mam> Mcl1<tm3Sjk>",null,"Recessive","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3",{"$nulls":61},"N/A","N/A"]
[6306,"myc/bcl-x","C57BL/6-Bcl2l1<tm1Mam> Tg(IghMyc)22Bri",null,"Semi-dominant","BCL2-like 1","Bcl2l1","Reduced","Bcl(X)L, bcl-x, Bcl-XL, Bcl-Xs, BclX ","MGI:88139","BCL2-like 1; targeted mutation 1, Lothar Hennighausen","Bcl2l1<tm1Mam>","MGI:2176699","2",{"$nulls":16},"transgene insertion 22, Ralph L Brinster","Myc promoter",{"$nulls":12},"C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","1148","true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6308,"N1C1 ","N1C1 ",{"$nulls":3}," Nlrp1a    Casp-1   ",{"$nulls":35},"Phenotype does not differ from a wildtype of the same genetic background.",null,"Balb/c and C57bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","4094","true",null,"Ben","Kile",{"$nulls":8},"N/A","N/A","No"]
[6324,"QkfTg-15","QkfBACRP23-360F23 Transgenic",{"$nulls":3},"   Qkf    ",{"$nulls":35},"Contact Researcher",null,"CBA x C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","4048","true",null,"Anne","Voss",{"$nulls":8},"N/A","N/A","No"]
[6740,"LauraKlf3KO","LauraKlf3KO/Ausb",{"$nulls":3},"Klf3",{"$nulls":35},"Mild.",null,"FVBn","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2712","true",null,"Richard","Pearson",{"$nulls":8},"N/A","N/A","No"]
[6316,"Raf/R26R","B6;129-Gt(ROSA)26Sor<tm1Sor> Pdgfra<tm8Sor>/JWehi",null,"Semi-dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano","Gt(ROSA)26Sor<tm1Sor>","MGI:1861932","6",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3480","true",null,"Owen","Prall","Walter and Eliza Hall Institute of Medical Research","prall@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6320,"Plt4 Rag","C57BL/6-Myb<Plt4> Rag1<tm1(GFP)Imku>",null,"Semi-dominant","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Nobuo Sakaguchi","Rag1<tm1(GFP)Imku>","MGI:2388344","2",{"$nulls":61},"N/A","N/A"]
[6323,"QkfTg","CBA.B6-Myst4<Gt(pKC199)1Pgr>",null,"Dominant","MYST histone acetyltransferase monocytic leukemia 4","Myst4","Normal","B130044K16Rik, KAT6B, monocytic leukemia, Morf, qkf, querkopf","MGI:1858746","MYST histone acetyltransferase monocytic leukemia 4; gene trap 1, Peter Gruss","Myst4<Gt(pKC199)1Pgr>","MGI:2679726","14",{"$nulls":30},"CBA x C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3745","true",null,"Anne","Voss","Walter and Eliza Hall Institute of Medical Research","avoss@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6328,"377SCID","RIP-B7.NOD.SCID",{"$nulls":3},"   Rip    ",{"$nulls":35},"  Phenotype does not differ from a wildtype of the same genetic background.",null,"NOD SCID backcross","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","484","true",null,"Len","Harrison",{"$nulls":8},"N/A","N/A","No"]
[6341,"1010","vav-Myc 10 x vav-Myc 10",{"$nulls":3}," vav-myc  ",{"$nulls":35},"Tumour development  T/+ mice develop thymoma or sub-cutaneous tumours (hystiocytic sarcoma) with a median onset of 41 weeks. T/T mice develop thymoma with a median onset of 13 weeks.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","338","true",null,"Suzanne","Cory",{"$nulls":8},"N/A","N/A","No"]
[6347,"Vavbcl/506","VavP-BCL2-69/BPH3 19B2",{"$nulls":3},"  Bcl-2    Bim/Pum  ",{"$nulls":35},"Excess B cells throughout life.  Develop glomerulonephritis, lymphoma and plasmacytoma  Enlarged spleens  lymphadenopathy (more white blood cells), larger (2-3fold) spleen and lymph nodes  ",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","2339","true",null,"Philippe","Bouillet",{"$nulls":8},"N/A","N/A","No"]
[6877,null,"ABCA1fl/fl ABCG1fl/fl",null,"Semi-dominant","ATP-binding cassette, sub-family A (ABC1), member 1","Abca1","Unknown","ABC1","MGI:99607",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-04-24","Cryopreserved sperm",50,0,null,null,"true",null,"Kerry-Anne","Rye","Heart Research Institute","ryek@hri.org.au",{"$nulls":3},"Blake","Cochran","cochranb@hri.org.au","2011/005",null,"No"]
[6877,null,"ABCA1fl/fl ABCG1fl/fl",null,"Semi-dominant","ATP-binding cassette, sub-family G (WHITE), member 1","Abcg1",null,"Abc8, White","MGI:107704",{"$nulls":3},"17",{"$nulls":58},"Blake","Cochran","cochranb@hri.org.au","2011/005"]
[6373,"BERT","B6.Cg-Cd79a<tm1(cre)Reth>/Max",null,"Dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a","Normal","Cd79a, Ig alpha, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1 ","MGI:101774 ","CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a<tm1(cre)Reth>","MGI:3687451","7",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2807","true",null,"Robert","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6390,"OT2tgTHY1cn40LKO","B6.Cg-Cd40lg<tm1Imx> Thy1<a> Tg(TcraTcrb)425Cbn/Ausb",null,"Recessive","thymus cell antigen 1, theta","Thy1","Normal","CD90, T25, theta, Thy 1.2, Thy-1, Thy-1.2, Thy1.1, Thy1.2 ","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":58},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A"]
[6401,"Stat3fOT2ThyLcre","B6.Cg-Stat3<tm1Desi> Thy1<a> Tg(Lck-cre)548Jxm Tg(TcraTcrb)425Cbn/Ausb",null,"Dominant","thymus cell antigen 1, theta","Thy1","Normal","CD90, T25, theta, Thy 1.2, Thy-1, Thy-1.2, Thy1.1, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":41},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A"]
[6403,"TOMGREtg","B6.129(Cg)-Gt(ROSA)26Sor<tm4(ACTB-tdTomato,-EGFP)Luo>/JAusb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Liqun Luo","Gt(ROSA)26Sor<tm4(ACTB-tdTomato,-EGFP)Luo>","gene trap ROSA 26, Philippe Soriano","6",{"$nulls":28},"Normal","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2495","true",null,"Robert","Brink","Garvan Institute","r.brink@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6412,"LYScre","B6.129P2-Lyz2<tm1(cre)Ifo>/JAusb",null,"Dominant","lysozyme 2","Lyz2","Normal","Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp","MGI:96897","lysozyme 2; targeted mutation 1, Irmgard Forster","Lyz2<tm1(cre)Ifo>","MGI:1934631","10",{"$nulls":28},"Unknown","Enlarged spleen:*Rare","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","294","true",null,"Tatyana","Chtanova","Garvan Institute","t.Chtanova@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6444,"Endo-cre","B6.Cg-Tg(PDGFB-cre)/Ausb?",{"$nulls":39},"?",null,"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2705","true",null,"Jenny","Gunton",{"$nulls":8},"N/A","N/A","No"]
[6441,"BI?","B6.Cg-Hif1a<tm1Stom> Tg(Ins2-cre)25Mgn/Ausb",null,"Semi-dominant","hypoxia inducible factor 1, alpha subunit","Hif1a","Nil","bHLHe78, HIF-1alpha, HIF1alpha, MOP1","MGI:106918","hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Shuhei Tomita","Hif1a<tm1Stom>","MGI:2677892","12",{"$nulls":16},"transgene insertion 25, Mark A Magnuson","rat insulin promoter (Ins2)",{"$nulls":10},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","328","true",null,"Jenny","Gunton","Garvan Institute","j.gunton@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6442,"bVDR","B6.Cg-Vdr<tm1Gcm>/Ausb",null,"Dominant","vitamin D receptor","Vdr","Normal","Nr1i1","MGI:103076","vitamin D receptor; targeted mutation 1, Geert Carmeliet","Vdr<tm1Gcm>","MGI:2183407","15",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2647","true",null,"Jenny","Gunton","Garvan Institute","j.gunton@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6456,"Y7f","B6.129-Npy7r<tm1>?",null,"Recessive",null,"Y7",{"$nulls":6},"Unknown",{"$nulls":30},"B6/129SVJ","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","715","true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[6494,"PRLACZKI","B6.Cg-Pgr<tm1Lyd>/Ausb",null,"Dominant","progesterone receptor","Pgr","Normal","9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 1, John P Lydon","Pgr<tm1Lyd>","MGI:3032652","9",{"$nulls":28},"Unknown","Unknown","129/B6","Yes","No","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","547","true",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6532,"IL2B6?","?",{"$nulls":3},"IL2",{"$nulls":37},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","739","true",null,"Jonathan","Sprent",{"$nulls":8},"N/A","N/A","No"]
[6883,"MKB ; Met-Kb","STOCK-Tg(sMt1-H2-K<b>)",null,"Dominant",{"$nulls":25},"mouse H2-K<b> (MHC class I)","Sheep metallothionein promoter","variable and slightly lower than wild type H2-K<b>. Expression can be induced with Zinc",{"$nulls":9},"Normal","Normal","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,null,"No","2012-05-02",null,0,0,null,null,"true",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":3},"Patrick","Bertolino","p.bertolino@centenary.org.au","K75/1-2012/3/5632","NLRD 536/2002, IBC 02-0025","No"]
[6534,"IL7tg","B6.Cg-Tg(H2-Ea-Il7)10Rhdr/ScrAusb",null,"Semi-dominant",{"$nulls":25},"transgene insertion 10, Rhodri Ceredig","H2-Ea promoter",{"$nulls":10},"Abnormal B cell morphology:*Proportion of pro/pre-B cells in the thymus is significantly increased.Abnormal double-negative T cell morphology:*5.3% of double negative cells in 6 week old thymus are CD19+, a significant increase compared to controls.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","380","true",null,"Jonathan","Sprent","Garvan Institute","j.sprent@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6558,"Gcre","GLIcreER",null,"Recessive",null,"G",{"$nulls":6},"Unknown",{"$nulls":30},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","732","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6568,"MyD88","B6.129P2-Myd88<tm1Aki>/Ausb ?",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira","Myd88<tm1Aki>","MGI:2385681","9",{"$nulls":28},"Increased apoptosis:*5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells.Increased physiological sensitivity to xenobiotic:*Knockout mice are more susceptible to bleomycin-induced lung injury.Increased dendritic cell number:*Increased numbers of dendritic cells in brains of mice infected with Plasmodium.Abnormal dendritic cell differentiation:*Dendritic cell maturation fails to occur in vivo upon exposure to TLR9 agonists.Abnormal immune system physiology:*Response to LPS and CpG is completely abrogated.      Abnormal dendritic cell physiology:      *Cytokine secretion elicited by zymosan or LPS is impaired.      *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40, IL-6 and interferon-gamma relative to wild-type mice.      Abnormal macrophage physiology:      *TNF production is impaired in thioglycollate-elicited macrophages treated with intact zymosan.      *Cytokine production by macrophages cultured with P. carinii cysts is reduced compared to wild-type.      Abnormal NK cell physiology:      *NK cells fail to make IFN-gamma in response to injections of TLR9 agonists.      Abnormal T cell physiology:      *Induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonists, was severely impaired.      Abnormal cytokine secretion:      *LPS-induced cytokine production by BMDCs is almost abolished compared to controls and Myd88-sufficient mutants.         Abnormal chemokine secretion:         *Hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice.         Decreased interferon-alpha secretion:         *CpG-A or RNA polyuridylic acid induced production of interferon-alpha was abolished in plasmacytoid dendritic cells.         Decreased interferon-gamma secretion:         *Less up regulation of INF-gamma in Plasmodium infection.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less interferon-gamma.         Decreased interleukin-12 secretion:         *After stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.         Decreased interleukin-12b secretion:         *Less upregulation of IL-12b in Plasmodium infection.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice.         Decreased interleukin-6 secretion:         *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, IL-6 secretion is reduced.         *Following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-6 relative to wild-type mice.         Decreased tumor necrosis factor secretion:         *Less upregulation of TNF-alpha in Plasmodium infection.         *Following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.         *After stimulation with zymosan, TNF production is significantly reduced in Myd88-deficient animals.      Decreased inflammatory response:      *In a model of induced pneumococcal meningitis-associated labyrinthitis, homozygotes exhibit a significantly lower granulocytic infiltration of the labyrinth and increased bacterial density in the cochlea at 24 hrs post-infection relative to wild-type control mice.      Abnormal response to infection:      *Following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a decreased immune response in terms of TNF and IL-6 secretion and response to CpG.         Decreased susceptibility to parasitic infection:         *Resistant to cerebral malaria but eventually die of extremely high parasitemia.         Increased susceptibility to viral infection:         *Increased susceptibility to encephalomyocarditis virus (EMCV) infection compared to wildtype.Abnormal susceptibility to hearing loss:*In a model of induced pneumococcal meningitis-associated labyrinthitis, homozygotes exhibit significantly less hearing impairment at 24 hrs post-infection in response to click, 1- or 10-kHz stimuli relative to wild-type control mice.Abnormal neuron differentiation:*Improved differentiation of progenitor cells into neurons.*Survival of newly formed neurons is reduced.Abnormal nervous system physiology:*After cold induced cortical injury, recruitment of neutrophiles to lesion site is reduced by 85% in comparison to controls.*Cold induced cortical lesion volume is reduced by 25% compared to controls.*Fewer cortical cells have damaged DNA compared to controls after cold induced cortical injury.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2344","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[6571,"R5RKI","GluR5(Q636R)-N6-bx129S6",null,"Recessive",null,"R5R",{"$nulls":6},"Unknown",{"$nulls":30},"SVEV","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo",0,0,"Moss Vale","792","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[7302,null,"SJL/Mrit<MRI49372>",null,"Dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Severe macrocytosis","Macrocytosis","SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2013-04-03","Cryopreserved sperm",47,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[3484,"uMT","C57BL/6-Igh-6<tm1Cgn>/Wehi",null,"Recessive","immunoglobulin heavy chain 6 (heavy chain of IgM)","Igh-6","Nil","BCR, Ig mu, Igh-M, Igh6, IgM, muH, muMT","MGI:96448","targeted mutation 1, University of Cologne","Igh-6<tm1Cgn>","MGI:1857187","12",{"$nulls":15},"Yes",{"$nulls":12},"B cell deficient and therefore immuno-compromised (no immunoglobulin but CTL intact).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-23",null,0,0,"WEHI","575","true",null,"David","Tarlinton","Walter and Eliza Hall Institute of Medical Research","tarlinton@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[5306,null,"C57BL/6-Mrc1<tm1Mnz>",null,"Recessive","mannose receptor, C type 1","Mrc1","Nil","CD206, MR","MGI:97142","mannose receptor, C type 1; targeted mutation 1, Michel C Nussenzweig","Mrc1<tm1Mnz>","MGI:2448258","2",{"$nulls":15},"No",{"$nulls":12},"Defective macrophage function.MR-/- mice were defective in clearing proteins bearing accessible mannose and N-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-11-05",null,0,0,"St V","178","true",null,"Anthony","D'Apice","St Vincent's Hospital Melbourne","Anthony.Dapice@svhm.org.au",{"$nulls":3},"Anthony","D'Apice","Anthony.Dapice@svhm.org.au","N/A","N/A","No"]
[7021,"SphK1 Tg","C57BL/6-Tg(CAG-Sphk1)/MarpApb",null,"Dominant",{"$nulls":25},"Sphingosine kinase 1a","chicken beta-actin promoter, CAG","Moderate - High",{"$nulls":9},"Normal","Normal","C57BL/6","No","Yes","Yes","No","Yes","Yes","No","Excellent","more than 9 times",null,"WT (-/-) x Het (+/-)","No","2012-07-19","Cryopreserved sperm",40,0,"Monash",null,"false",null,"Clinton","Bruce","Baker IDI Heart and Diabetes Institute","clinton.bruce@monash.edu",{"$nulls":3},"Clinton","Bruce","clinton.bruce@monash.edu","M-596","PC1-N08-08","No"]
[5713,"CYP 26 KO ",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[3581,null,"NOD.Cg-Prkdc<scid> IL2rg<?>",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg","Nil","[g]c, CD132, common cytokine receptor gamma chain, common gamma chain, gamma C receptor, gamma(c)","MGI:96551",{"$nulls":3},"X",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Histological examination of lymphoid tissues reveals absence of lymphoid cells and some cystic structures in the thymus, an absence of follicles in the spleen and markedly diminished celluarity of lymph nodes. Double mutants are deficient in mature lymphocytes, serum Ig is not detectable and natural killer (NK) cell cytotoxic activity is extremely low. These mice are resistant to lymphoma development even after sublethal irradiation treatment. These mice have been shown to readily support engraftment of human CD34+ hematopoietic stem cells and represent a superior, long-lived model suitable for studies employing xenotransplantation strategies.   Hemizygous males display:  • immune system, other dysmorphology:  • thymus: small, hypoplastic, cortex reduced in size, ndistinct corticomedullary junction  • peripheral lymph nodes absent  • mesenteric lymph node: small, contained few lymphoid follicles, contained few lymphocytes, contained no germinal centers, gut-associated lymph tissue absent in small and large intestine  • spleens at 3 weeks: modestly decreased size, severe lymphocyte hypoplasia evident in white pulp, B cell and marginal zones absent  • spleens at 4 to 9 weeks: increase in splenic lymphocytes, splenomegaly, dendritic epidermal T cells absent, gamma-delta-positive intestinal intraepithelial lymphocytes absent, immune system, lymphoid development/T lymphocyte defects:  • thymic T cells showed: reduction in absolute numbers, increase in ratio of CD4+ to CD8+ single-positive cells, increased percentage of CD4+ single-positivecells  • splenic T cells at 3 weeks showed: increase in ratio of CD4+ to CD8+ single-positive cells, decreased percentage of CD8+ single-positive cells, marked increase in CD4 to CD8 ratio at 4 to 9 weeks, NK cells absent  • immune system, lymphoid development/B lymphoid defects: overall decrease in B cell numbers, nearly absent in bone marrow, markedly reduced in spleen, decreased concentrations of immunoglobulins in mice greater than 5 weeks of age  • digestive system, dysmorphology: inflammation of the cecum and colitis","Heterozygous females display:  • no obvious phenotype, no defect detected","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-08-04",null,0,0,"WEHI","1500","true",null,"Catheryn","O'Brien","Walter and Eliza Hall Institute of Medical Research","Obrien@wahi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6744,"LN-KIf3KIf8FV","Laura KIf3KIf8-GT-FVB/N/Ausb",{"$nulls":3},"Klf3,Klf8",{"$nulls":35},"Homozygous lethal",null,"FVBn","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2814","true",null,"Richard","Pearson",{"$nulls":8},"N/A","N/A","No"]
[5717,"D-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6745,"KIf3-Cherry","KIf3m-Cherry/Ausb",{"$nulls":3},"Klf3",{"$nulls":35},"KO generally mild but appear less healthy than WT littermates.KO are smaller than WT littermates.KO lifespan suspected to be reduced.",null,"C57BL6/129SV/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2817","true",null,"Richard","Pearson",{"$nulls":8},"N/A","N/A","No"]
[3935,"RRF","BALB/c-Gt(ROSA)26Sor<tm1(FLII)Hdc>/AnuApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hugh D Campbell","Gt(ROSA)26Sor<tm1(FLII)Hdc>","MGI:4939369","6",{"$nulls":28},"Normal","Normal.No analysis performed","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","4",null,"Hom x Hom","No","2008-10-16","Cryopreserved sperm",80,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Ruth","Arkell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[6886,"APN174","C57Bl/6N-Map3k5<tm1a(EUCOMM)Hmgu>/MarpApb",null,"Recessive","mitogen-activated protein kinase kinase kinase 5","Map3k5","Unknown","7420452D20Rik, ASK, ASK1, Mekk5","MGI:1346876","mitogen-activated protein kinase kinase kinase 5; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH ","Map3k5<tm1a(EUCOMM)Hmgu>","MGI:4434801","10",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-05-03","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS 2010/08","PC1N09/07","No"]
[6591,"TRPC1","B6;129S-Trpc1<tm1Lbi>/Dfat",null,"Recessive","transient receptor potential cation channel, subfamily C, member 1","Trpc1","Nil","Mtrp1, Trp1, Trrp1","MGI:109528","transient receptor potential cation channel, subfamily C, member 1; targeted mutation 1, Lutz Birnbaumer","Trpc1<tm1Lbi>","MGI:3764882","9",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-29",null,0,0,"Victor Chang",null,"true",null,"Diane","Fatkin","Victor Chang Cardiac Research Institute","d.fatkin@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","NLRD 3026/2010","No"]
[8632,"Dmp1Cre.Efnb2","B6.Cg-Efnb2<tm2And> Tg(Dmp1-cre)1Jqfe",null,"Recessive","ephrin B2","Efnb2",null,"ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1","MGI:105097","ephrin B2; targeted mutation 2, David J Anderson","Efnb2<tm2And>","MGI:2176538","8",{"$nulls":16},"transgene insertion 1, Jian Q Feng","Dmp1","odontoblast-specific",{"$nulls":9},"Normal bone shape and cortical width with a low bone material strength due to hypermineralization","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-12-20","Cryopreserved sperm",48,0,"St V",null,"false",null,"Natalie","Sims","St. Vincent's Institute","nsims@svi.edu.au",{"$nulls":8},"No"]
[6608,"BXD-75","BXD75/RwwJArc",null,"Recessive",{"$nulls":37},"Normal","Normal","C57BL/6J x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"brother x sister","No","2011-10-04","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[7592,null,"SJL/ASAM<MRI40941>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","The mice displays an harmonious growth retardation phenotype without other gross abrnomalities. The mice are viable and fertile.","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","5",null,null,"No","2014-02-18","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[6604,"BXD-48","BXD48/RwwJArc",null,"Recessive",{"$nulls":37},"Normal","Normal","C57BL/6J x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"brother x sister","No","2011-10-04","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[6755,"P2X2KO","B6.129-P2rx2<tm1Ckn>/J/Ausb",null,"Recessive","purinergic receptor P2X, ligand-gated ion channel, 2 ","P2rx2","Nil","P2x2, P2X2a ","MGI:2665170","purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Debra A Cockayne ","P2rx2<tm1Ckn>","MGI:2687349","5",{"$nulls":28},"Decreased pulmonary ventilation:*In response to hypoxia (10% O2), adult homozygotes (4-6 months of age) display a significantly reduced ventilatory response showing an increase of only 261 +/- 202 ml/min/kg in minute ventilation (VE) relative to 1008 +/- 154 ml/min/kg in wild-type controls.*In response to further hypoxia (7.5% O2), homozygotes display a severe ventilatory depression with the VE reduced below prehypoxic levels by 606 +/- 209 ml/min/kg, unlike wild-type controls where no additional increase in ventilation is observed but the VE remains above normoxic levels.*However, adult homozygotes display normal resting ventilation during normoxia and show normal ventilatory responses to a mild (15% O2) hypoxia relative to wild-type controls.Abnormal carotid body physiology:*Homozygotes show a dramatic reduction in afferent nerve responses of the carotid sinus nerve to a decrease in oxygen tension (PO2).*Unlike in in vitro carotid body-sinus nerve preparations from wild-type mice where sinus nerve discharge increases from baseline to a peak of 130.82 +/- 10.79 spikes/sec during hypoxia, the afferent discharge in preparations from mutant mice only reaches a peak of 58.13 +/- 9.40 spikes/sec, indicating that carotid body function is impaired.*The average peak firing rate of single units induced by hypoxia is significantly lower in carotid body-sinus nerve preparations from mutant mice (1.64 +/- 0.11 spikes/sec) relative to that observed in wild-type preparations (7.96 +/- 0.88 spikes/sec).Homeostasis/metabolism phenotype:*In response to hypoxia (7.5% O2), adult homozygotes display normal decreases in body temperature relative to wild-type controls (0.9 +/- 0.2 vs 0.8 +/- 0.1 degress Celsius, respectively).",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2156","true",null,"Gary","Housley","Moss Vale","g.housley@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6750,"CD11cDTR","B6.Cg-Tg(Itgax-DTR/EGFP)57Lan/Ausb",null,"Semi-dominant",{"$nulls":25},"transgene insertion 57, Richard A Lang","mouse Itgax promoter (CD11c)",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-02",null,0,0,"ABR - Moss Vale","2500","true",null,"Wendy","Jessup","The University of New South Wales","w.jessup@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7111,"APN278 (ARL SPF)","C57BL/6N-Dsg2<tm1a(EUCOMM)Wtsi>Mu",null,"Recessive","desmoglein 2","Dsg2 ",null,"D18Ertd293e ","MGI:1196466 ","desmoglein 2; targeted mutation 1a, Wellcome Trust Sanger Institute ","Dsg2tm1a(EUCOMM)Wtsi","MGI:4432319","18",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Yes","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-10-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[6892,"Gp130/IL10) (ME-263)","B6-Il6st<tm1Ern> Il10<tm1Cgn>/LudApb",null,"Dominant","interleukin 6 signal transducer","Il6st","Unknown","5133400A03Rik, CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst ","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":28},"Homozygous mice do not breed when mated together.gp130<Y757F> mice develop gastric polyps.","Unknown","C57BL/6","Yes","No","Unknown","Yes","No","Unknown","No","Unknown",{"$nulls":3},"No","2012-05-10","Cryopreserved sperm",49,0,"Ludwig","ME-263","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","304","No"]
[191,"FAP -/-","C57BL/6-Fap<tm1Schn>",null,"Recessive","fibroblast activation protein","Fap","Nil",null,"MGI:109608","targeted mutation 1, Andreas Schnapp","Fap<tm1Schn>","MGI:2386791","2",{"$nulls":15},"No",{"$nulls":12},"None detected. No change in cancer susceptibility",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-17",null,0,0,null,null,"true",null,"Mark","Gorrell","Centenary Institute","M.Gorrell@centenary.usyd.edu.au",{"$nulls":3},"Mark","Gorrell","M.Gorrell@centenary.usyd.edu.au","N/A","N/A","No"]
[229,null,"ECFP",null,"Dominant",{"$nulls":25},"Cyan Fluorescent Protein",{"$nulls":11},"Mice that are homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioural abnormalities.  All tissues from hemizygous animals display fluorescence in all cell types under appropriate lighting conditions.  Homozygotes fluoresce with twice the intensity of the hemizygotes.  Notable exceptions to this phenotype are erythrocytes and adipocytes in with fluorescence is negligible or absent.  Coat colour expected from breeding: albino, agouti",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-25",null,0,0,null,null,"true",null,"Patrick","Tam","Children's Medical Research Institute","ptam@cmri.usyd.edu.au",{"$nulls":3},"Patrick","Tam","ptam@cmri.usyd.edu.au","N/A","N/A","No"]
[7598,"Stk35KO or Clik1KO","B6.129-Stk35<tm1>/MarpApb",null,"Semi-dominant","serine/threonine kinase 35 ","Stk35","Nil","1700054C12Rik, CLIK1, CLP-36 interacting kinase","MGI:1914583",{"$nulls":3},"2",{"$nulls":28},"Male and female subfertility/infertility and abnormal eye development","Variable from subfertility to normal.","SV129/C57Bl6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",{"$nulls":3},"No","2014-02-19","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Kate","Loveland","Monash University","kate.loveland@monash.edu",{"$nulls":3},"Elizabeth (Liz)","Richards","elizabeth.a.richards@monash.edu","MARP2012/107/BC","PC1-N22-10","No"]
[6788,"APN 253","C57BL/6N-Kat5 <Gt(IST12384G7)Tigm>/Marp",null,"Recessive","K(lysine) acetyltransferase 5 ","Kat5 ","Unknown","Htatip, mHTATIP/CPLA2, PLIP, Tip60 ","MGI:1932051 ","\tgene trap IST12384G7, Texas A&M Institute for Genomic Medicine ","Gt(IST12384G7)Tigm","MGI:4076960","19",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2012-01-18","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MAS/MAS 2010/08","PC1-N09/07","No"]
[8643,"Dap10/Dap12 double knock out (Dap10/12 DKO)","B6.129-Hcst/Tyrobp<tm1Ttk>/Ttk",null,"Recessive","hematopoietic cell signal transducer","Hcst","Nil","DAP10, KAP10","MGI:1344360","hematopoietic cell signal transducer; targeted mutation 1, Toshiyuki Takai","Hcst/Tyrobp<tm1Ttk>","MGI:3840566","7",{"$nulls":28},"Normal; Mice lack Ly49H on cell surface\t","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-01-23","Cryopreserved sperm",50,0,null,null,"false",null,"Andrew","Brooks","Peter Doherty Institute for Infection and Immunity","agbrooks@unimelb.edu.au",{"$nulls":8},"No"]
[5668,"CBB6F1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5670,"CD1/Z Red",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[6773,"DBC3 KO Cre deleted ; BRINP3 KO","C57BL/6-Fam5c<tm1.1SBer>",null,"Recessive","family with sequence similarity 5, member C","Fam5c","Nil","B830045N13Rik;  Brinp3","MGI:2443035",{"$nulls":3},"1",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-01-11",null,0,0,null,null,"true",null,"Susie","Berkowicz","Monash University","Susie.berkowicz@monash.edu",{"$nulls":3},"Susie","Berkowicz","Susie.berkowicz@monash.edu","SOBS/B/2008/30BC","N/A","No"]
[7309,"K5rTA-Rae1-29","C57BL/6-Tg(K5-rTA)04Cbn Tg(TetO-RaeT1e)29Cbn/Apb",null,"Dominant",{"$nulls":25},"tetracycline-regulated transcriptional transactivator","bovine keratin-5",{"$nulls":10},"In these mice following oral doxycyline treatment, rTA expresssion induced in the skin activates the TetO promoter driving RaeT1e expression in the skin.","As for homozygous mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"5","Tg Tg x Tg Tg","No","2013-04-09","Cryopreserved sperm",45,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","1112345","2011-032","No"]
[7042,"Loco","ENU20 Bcl2:016:a:B6",null,"Recessive","caspase recruitment domain family, member 11","Card11","Unknown",null,"MGI:1916978","loco",null,null,"5",{"$nulls":16},"transgene insertion 1, Jerry M Adams","mouse Vav promoter",{"$nulls":10},"No Treg cells","Decreased circulating Treg cells.","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor","G6","3","best to maintain clony with Het breeders, hom's produced small litters size","No","2012-08-06","Cryopreserved sperm",65,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","A2011/41",null,"No"]
[7307,"RIP-OVAlo","C57BL/6-Tg(Ins2-OVA)307Wehi/WehiApb","C57BL/6-Tg(Ins2-OVA)307Wehi/WehiApb","Dominant",{"$nulls":25},"transgene insertion 307, Walter and Eliza Hall Institute of Medical Research","rat insulin 2","low (relative to RIP-OVAhi mice)",{"$nulls":9},"Normal. Mice express OVA in the pancreas beta cells. ","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,">30","brother-sister or Tg x C57BL/6","No","2013-04-09","Cryopreserved sperm",50,0,null,null,"false",null,"William","Heath","The University of Melbourne","wrheath@unimelb.edu.au",{"$nulls":3},"Gayle","Davey","daveyg@unimelb.edu.au","1112326","2011-032","No"]
[5542,"Wonggan (Wong); ENU14nih 002","ENU14NIH:002",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Embryos @14.5 appear smaller than normal, have increased KLS cell in fetal liver, increased primitive RBCs and decreased definitive RBCs.","normal","C57BL/6JAnu x C57BL/10","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2011-07-19","Cryopreserved sperm",18,0,null,null,"true",null,"Andrew","Perkins","The University of Queensland","a.perkins@imb.uq.edu.au",{"$nulls":3},"Robert","Tunningley","robert.tunningley@anu.edu.au","J.APF.13.08","N/A","No"]
[5325,"Acc2 floxed","C57BL/6-Acacb<flox>/Apb",null,"Dominant","acetyl-Coenzyme A carboxylase beta","Acacb","Normal","Acc2, Accb","MGI:2140940",{"$nulls":3},"5",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Homozygous pairs","No","2010-11-18","Cryopreserved sperm",50,0,null,null,"false",null,"David","James","Garvan Institute","d.james@garvan.org.au","384 Victoria Street, Darlinghurst","Sydney","NSW","David","James","d.james@garvan.org.au","05/43","2693","No"]
[5554,"N1A-dko","Nox1-ApoE double knockout mouse",null,"Recessive","apolipoprotein E","Apoe",null,null,"MGI:88057",{"$nulls":3},"7",{"$nulls":58},"Courtney","Judkins","courtney.judkins@monash.edu","SOBSB/PHAR/2007/14bc","PC1-N34/09"]
[5326,"Robo1 DuLox","C57BL/6-Robo1<tm1Wlan>",null,"Dominant","roundabout homolog 1 (Drosophila)","Robo1","Nil","DUTT1","MGI:1274781","roundabout homolog 1 (Drosophila); targeted mutation 1, William Andrews","Robo1tm1Wian","MGI:3772898","16",{"$nulls":15},"No",{"$nulls":12},"Homozygous mice viable as adults.Increased number of cortical interneurons.Abnormal embryonic/fetal subventricular zone morphology: cell cultures of ganglionic eminence exhibit increased cell proliferation compared to wild-type cells.Abnormal neurite morphology: in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching.","Heterozygous mice viable as adults.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x hom, Hom x Het, Het x Het, Hom x Wildtype","No","2010-11-18",null,0,0,null,null,"true",null,"Linda","Richards","Queensland Brain Institute","richards@uq.edu.au","QBI Building (#79), Upland Road, The University of Queensland","St. Lucia","QLD","John","Baisden","j.baisden@uq.edu.au","QBI/165/09/BREED/NHMRC/ARC (NF)","NLRD  1595/2005","No"]
[8648,"ENU45:G2","ANU:ENU45:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2019-01-31","Cryopreserved sperm",1957,0,"ANU",null,"false",null,"The Australian ","Phenomics Facility","The Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[7354,"Lck-Cre:Foxo1-flox","B6.129-Foxo1<tm1Flv> Tg(Lck-cre)157Jxm/Anu",null,"Recessive","forkhead box O1","Foxo1","Normal","Afxh, FKHR, Fkhr1, Foxo1a","MGI:1890077","forkhead box O1; targeted mutation 1, Richard A Flavell","Foxo1<tm1Flv>","MGI:3840910","3",{"$nulls":16},"targeted mutation I57, Jamey Marth; transgene insertion I57, Jamey Marth","mouse proximal Lck promoter","active in thymocytes and splenocytes",{"$nulls":11},"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-06-19","Cryopreserved sperm",30,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4879,"Bc.Rag1.KO","C.B6-Rag1<tm1Mom>/ArcStvApb",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.",null,"BALB/c x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","6",null,null,"No","2009-09-28","Cryopreserved sperm",90,0,"St V","038","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML 89","94","No"]
[5331,"Pdx1-GFP","C57BL/6-Pdx1<tm1Egs>/MarpApb",null,"Recessive","Pancreatic and duodedenal homeobox gene 1","Pdx1","Reduced","IDX-1, IPF-1, Ipf1, Mody4, pdx-1, STF-1","MGI:102851","pancreatic and duodenal homeobox 1; targeted mutation 1, Edouard G Stanley","Pdx1<tm1Egs>","MGI:3688420","5",{"$nulls":15},"Yes",{"$nulls":12},"Pdx1 null mice lack a pancreas","Reduce glucose responsiveness","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","more than 15 back-crossed to B6",null,"Pdx1-GFP males mated with C57BL/6 hets ","No","2010-11-24","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Ed","Stanley","Monash University","ed.stanley@monash.edu","Level 3, Building 75, Monash University","Clayton","Vic","Ed","Stanley","ed.stanley@monash.edu","SOBSA/MIS/2008/50 BC","NLRD1333_2004 ","No"]
[5477,"Espresso ; Ts5 flox/flox","C57BL/6-Adamts5<tm1>/Mrch",null,"Dominant","a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)","Adamts5","Normal","ADAM-TS5","MGI:1346321",{"$nulls":3},"16",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","6","no",null,"Yes","2011-04-07","Cryopreserved sperm",57,0,null,null,"true",null,"John","Bateman","Murdoch Childrens Research Institute","john.bateman@mcri.edu.au","Royal Children","Parkville","Victoria","Leonie","Tutolo","leonie.tutolo@mcri.edu.au","A605","2290/2007","No"]
[5105,"APN23, RRR232","B6;129-Tbc1d15<Gt(RRR232)Byg>/Marp",null,"Recessive","TBC1 domain family, member 15","Tbc1d15","Unknown","Ly6dl","MGI:1913937","TBC1 domain family, member 15; gene trap RRR232, BayGenomics","Tbc1d15<Gt(RRR232)Byg>","MGI:4397430","10",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-04-30","Cryopreserved sperm",50,0,"Monash",null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","sue.chapman@monash.edu","MMCA SOP 2007/02","PC1-N09/07","No"]
[5311,"Robo 2 KO","C57BL/6-Robo2<tm1.1Rilm>",null,"Dominant","roundabout homolog 2 (Drosophila)","Robo2",null,null,"MGI:1890110","roundabout homolog 2 (Drosophila); targeted mutation 1.1, Richard Maas","Robo2<tm1.1Rilm>","MGI:3759448","16",{"$nulls":15},"No",{"$nulls":12},"Fail to survive after birth.  Multiple ureter buds resulting in multiple ureters.  May have midline defects in the brain.","Unknown. Heterozygous mice used to maintain colony.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Heterozygous x Wild Type","No","2010-11-08",null,0,0,null,null,"true",null,"Linda","Richards","Queensland Brain Institute","richards@uq.edu.au","QBI Building (#79), Upland Road, The University of Queensland","St. Lucia","QLD","Linda","Richards","richards@uq.edu.au","QBI/165/09/BREED/NHMRC/ARC (NF)","NLRD  1595/2005","No"]
[5439," Men1fl/fl ; Miles","B6;129T2-Men1<tm1Gfk>/Apb","B6;129T2-Men1<tm1Gfk>","Recessive","multiple endocrine neoplasia type 1","Men1","Nil","menin","MGI:1316736","multiple endocrine neoplasia 1; targeted mutation 1, Graham F Kay","Men1<tm1Gfk>","MGI:2384620","19",{"$nulls":15},"No",{"$nulls":12},"Normal.However tissue specific deletion of Men1 using RIP-Cre transgenic mice (C57BL/6-Tg(Ins2-cre)25Mgn/J) results in tumour formation in pancreatic islets and pituitary.","Normal","mixed C57BL/6 and 129T2/SvEms","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","N/A","8","homozygous cross","No","2011-02-17","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Nicholas","Hayward","Queensland Institute of Medical Research","nick.hayward@qimr.edu.au","300 Herston Road","Brisbane","QLD","Magdalena","Auret","maggieA@qimr.edu.au","A0502-602M","1859-2012","No"]
[7057,"Rbm5 KO","B6;129P2-Rbm5<Gt(PST20293)Mfgc>/Marp",null,"Recessive","RNA binding motif protein 5","Rbm5","Unknown",null,"MGI:1933204","RNA binding motif protein 5; gene trap PST20293, Mammalian Functional Genomics Centre","Rbm5<Gt(PST20293)Mfgc>","MGI:3902497","9",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","C57BL/6 x 129P2/OlaHsd","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-08-22","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Duangporn","Jamsai","Monash University","duangporn.jamsai@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[5508,"Fh2","FVB/N-Tg(ACTA1-Fhl1)12Hrd/Apb",null,"Dominant",{"$nulls":25},"human four and a half LIM domains 1","Human Skeletal Actin Promoter",{"$nulls":10},"Unknown","Increased whole-body strength and fatigue resistance","FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","N.A.","N.A.","heterozygote males crossed with FVB/N females","No","2011-05-20","Cryopreserved sperm",100,0,"ABR - Moss Vale",null,"false",null,"Edna","Hardeman","The University of New South Wales","e.hardeman@unsw.edu.au","Wallace Wurth Building (C27) Rm 502A","Sydney","NSW","Edna","Hardeman","e.hardeman@unsw.edu.au","09/26A","09/023","Yes"]
[5488,"B6NRG","C57BL/6-Tg(Vav1-Nup98/Rap1gds1)1Apla/Apb",null,"Dominant",{"$nulls":25},"Nup98-Rap1GDS1","Vav1",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"T/+ male X +/+ female, maintain on c56Bl/6 background","No","2011-04-20","Cryopreserved sperm",50,0,null,null,"false",null,"Christopher","Slape","Walter and Eliza Hall Institute of Medical Research","slape@wehi.edu.au","300 Grattan St","Parkville","Victoria","Jesslyn","Saw","saw@wehi.edu.au","0809249","340/2002","No"]
[7315,"RNAi-9","C57BL/6J-HDAC1 219F<RNAi>",null,"Dominant","histone deacetylase 1","Hdac1","Unknown","HD1, MommeD5, RPD3","MGI:108086",{"$nulls":3},"4",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2013-04-11","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[5539,"Looptail","A.C3H-Vangl2<Lp>/MarpApb",null,"Semi-dominant","vang-like 2 (van gogh, Drosophila)","Vangl2","Reduced"," loop-tail, Lpp1, Ltap, mKIAA1215, ska<m17Jus>, ska17, strabismus","MGI:2135272","vang-like 2 (van gogh, Drosophila); loop tail","Vangl2<Lp>","MGI:1857642","1",{"$nulls":28},"Embryonic lethal - craniorachischisis","Heterozygous mice have a curly tail, abnormal head movement - rocking or wobbling, impaired balance, spina bifida in 5% of mice.","C3H","No","No","Yes","No","No","Yes","Yes","Good",null,null,"wildtype x heterzygote","No","2011-07-18","Cryopreserved sperm",50,0,null,null,"false",null,"Stephen","Jane","Monash University","stephen.jane@monash.edu",{"$nulls":3},"Alana","Auden","alana.auden@monash.edu","0810864","340/2002","No"]
[5388,"Fat Aussie","BALB/c-Alms1<foz>/AnuApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Mice are hyperphagic leading to obesity . Males are sterile. High fat feeding accelerates obesity development. Compared to foz/foz mice on NOD.B10 background, BALB/c foz/foz mice do not develop diabetes and liver disease is less severe.","normal","BALB/c","Yes","Unknown","Yes","Yes","No","Yes","Yes","Good",">10",null,"heterozygote mating","No","2011-01-17","Cryopreserved sperm",39,0,"ANU",null,"false",null,"Geoffrey","Farrell","The Australian National University","geoff.farrell@anu.edu.au","PO Box 11","Woden","ACT","Claire","Larter","claire.larter@anu.edu.au","F.MS.16.08","n/a","Yes"]
[5128,"152","B6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz",null,"Dominant",{"$nulls":25},"transgene insertion 152H, Laurence Ozmen","Thy1 promoter driving expression of the human APP ; Prnp promoter driving the expression of human PSEN2",{"$nulls":11},"Abnormal spatial learning: * in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice. * in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice.Impaired coordination: on at rotarod at 4 months.Amyloid beta deposits: * from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice. * amyloid beta deposits worsen with age.Increased body weight: at 4 to 12 months","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-05-20","Cryopreserved sperm",30,0,null,null,"true",null,"Juergen","Goetz","Brain and Mind Research Institute","jgoetz@med.usyd.edu.au",{"$nulls":3},"Juergen","Goetz","jgoetz@med.usyd.edu.au","K00/1-2009/3/4914 and K00/1-2009/3/4915","IBC#08NO32","No"]
[5226,"APN 55","C57BL/6N-Hsd11b1<tm1a(KOMP)Wtsi",null,"Recessive","hydroxysteroid 11-beta dehydrogenase 1","Hsd11b1","Nil","11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1","MGI:103562","hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1a, Wellcome Trust Sanger Institute","Hsd11b1<tm1a(KOMP)Wtsi>",null,"1",{"$nulls":15},"No",{"$nulls":12},"Unknown","Normal","C57BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Excellent",null,null,"Chimeras mated with wildtype C57BL/6N","No","2010-10-01","Cryopreserved sperm",50,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu","Monash University, School of Biomedical Sciences, Level 3, Building 77, Room 306","Melbourne","VIC","Sue","Chapman","sue.chapman@med.monash.edu.au","MMCA SOP 2007/02","PC1-N09/07","No"]
[5319,"F/F x Mal ; gp130Y757F x Mal","B6;129-Il6st<tm1Ern> Tirap<tm1.1Pjh>/MarpApb",null,"Dominant","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes",{"$nulls":12},"Mice develop gastric and inflammation and tumours, as well as splenomegaly and lymphadenopathy.","If the mice are heterozygous for the gp130 knock-in mutation (F+) then the mice appear normal. ","C57BL/6 x 129Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"homozogous x homozygous","No","2010-11-12","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Brendan","Jenkins","Monash University","brendan.jenkins@monash.edu",{"$nulls":3},"Brendan","Jenkins","brendan.jenkins@monash.edu","asop 2008-25","PC1 - N06/08","No"]
[4863,null,"FVB/N-CD151<floxLka>/Apb",null,"Recessive","CD151 antigen","Cd151","Normal","PETA-3, SFA-1, Tspan24","MGI:1096360",{"$nulls":3},"7",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",135,0,"ABR - Moss Vale",null,"false",null,"Leonie","Ashman","The University of Newcastle","Leonie.Ashman@newcastle.edu.au",{"$nulls":3},"Leonie","Ashman","Leonie.Ashman@newcastle.edu.au","1024","247/2008","No"]
[5232,"Ben","C57BL/6-Tigd2<tm1>",null,"Recessive","tigger transposable element derived 2","Tigd2","Nil",null,"MGI:1915390",{"$nulls":3},"6",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-10-08","Cryopreserved sperm",50,0,null,null,"false",null,"Richard","Saffery","Murdoch Childrens Research Institute","richard.saffery@mcri.edu.au","10th floor Royal Children","Parkville","Victoria","Sophie","Agius","sophie.agius@mcri.edu.au","A539","84ext-2006 PC1-NLRD","No"]
[8660,"SHMR","B6.Cg-Msh2<tm1Ndw> Rag1<tm1Bal> Samhd1<em1Cjo>/Cjo",null,"Recessive","SAM domain and HD domain, 1","Samhd1",null,"E330031J07Rik","MGI:1927468",{"$nulls":3},"2"]
[7603,null,"SJL/ASAM<MRI115158>",null,"Dominant","unknown","unknown","Reduced",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Normal","SJL/J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","2",null,null,"No","2014-02-24","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[5320,"Robo 1 KO","B6,129-Robo1<tm1.1Ljr>/Apb",null,"Dominant","roundabout homolog 1 (Drosophila)","Robo1","Nil","DUTT1","MGI:1274781","roundabout homolog 1 (Drosophila); targeted mutation 1.1, Linda J Richards","Robo1<tm1.1Ljr>","MGI:3641236","16",{"$nulls":15},"No",{"$nulls":12},"Malformation in the corpus callosum (axons tracing a dorso-ventral path instead of medio-lateral). Disruption of the hippocampal commissure. Fornix malformation. Some disruption of midline zipper glia.","Normal callosal projections.","C57BL/6","No","No","Yes","No","No","Yes","No","Good",null,null,"Het x Wt","No","2010-11-16","Cryopreserved sperm",50,0,"UQ",null,"false",null,"Linda","Richards","Queensland Brain Institute","richards@uq.edu.au","QBI Building (#79), Upland Road, The University of Queensland","St. Lucia","QLD","Linda","Richards","richards@uq.edu.au","QBI/165/09/BREED/NHMRC/ARC (NF)","NLRD  1595/2005","No"]
[4770,"B6.Asciz<tm1Jhh>","C57BL/6-Atmin<tm1.2Jhh>/JhhApb",null,"Dominant","ATM interactor","Atmin","Normal","Asciz, MGC:79206, mKIAA0431","MGI:2682328","ATM interactor; targeted mutation 1.2, Jorg Heierhorst","Atmin<tm1.2Jhh>","MGI:5463937","8",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2009-05-06","Cryopreserved sperm",90,0,"St V",null,"false",null,"Jorg","Heierhorst","St Vincent's Institute","jheierhorst@svi.edu.au",{"$nulls":3},"Jorg","Heierhorst","jheierhorst@svi.edu.au","SVH AEC 45/07","SPPL#25 IBC #069","No"]
[5570,"MCC floxed","B6.Cg-Mcc<tm1Maija>/AusbApb","Maija","Recessive","mutated in colorectal cancers","Mcc",null,null,"MGI:96930",{"$nulls":3},"18",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-08-29","Cryopreserved sperm",50,0,"ABR - Moss Vale",null,"false",null,"Maija","Kohonen-Corish","Garvan Institute","m.corish@garvan.org.au",{"$nulls":3},"Maija","Kohonen-Corish","m.corish@garvan.org.au","10/40","2306/2007","Yes"]
[4949,"GreenSox","B6;CBA-Tg(Sox3-IRES-GFP)/Apb",null,"Dominant",{"$nulls":25},"SRY-box containing gene 3 - green fluorescent protein fusion",{"$nulls":11},"Normal","Normal","C57BL/6 x CBA","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",null,null,"Tg/+ male to wt female","No","2009-12-04","Cryopreserved sperm",90,0,null,null,"false",null,"Paul","Thomas","The University of Adelaide","paul.thomas@adelaide.edu.au",{"$nulls":3},"Paul","Thomas","paul.thomas@adealdie.edu.au","S/74/08, S/75/08","NLRD 1952/2006","No"]
[5675,"CD11xC57xBALB/c",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5081,"Slc2a6 (Glut6) conditional KO","C57BL/6-Slc2a6<Flox>",null,"Recessive","solute carrier family 2 (facilitated glucose transporter), member 6","Slc2a6","Normal","Glut6, Glut9","MGI:2443286",{"$nulls":3},"2",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2010-03-25","Cryopreserved sperm",60,0,null,null,"true",null,"The Australian","Phenomics Network","Monash University","sue.chapman@monash.edu",{"$nulls":3},"Sue","Chapman","sue.chapman@monash.edu","MMCA 2007/17","PC1-N09/07","No"]
[5054,"NOD.B6 R11 N12","NOD.B6(D1Mit495-D1Mit286)N12",null,"Recessive",{"$nulls":37},"The incidence of diabetes has not been tested in this mouse strain as yet but may prove useful in the dissection of the Idd5.4 susceptibility locus.","The incidence of diabetes has not been tested in heterozygotes of this mouse strain.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","12","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm",45,0,null,null,"true",null,"Richard","Strugnell","The University of Melbourne","rastru@unimelb.edu.au",{"$nulls":3},"Kim","Simpfendorfer","k.simpfendorfer@pgrad.unimelb.edu.au","0703883","NLRD 2278/2007","No"]
[5500,"H2az","C.129P2-H2afz<tm1Ily>/Apb",null,"Recessive","H2A histone family, member Z","H2afz","Nil","H2A.Z","MGI:1888388","H2A histone family, member Z; targeted mutation 1, Ian Lyons","H2afz<tm1Ily>","MGI:2387764","3",{"$nulls":15},"Yes",{"$nulls":12},"Embryonic Lethality: Homozygous lethal with embryos dying from 3.5-6.5 d.p.c.Abnormal inner cell mass: cells derived from the inner cell mass of cultured blastocysts fail to persist whereas trophectoderm does persist","Heterozygotes appear normal and are fertile.","BALB/c","No","No","Yes","No","No","Yes","No","Good","Unknown but over 10","Unknown","Heterozygous intercross or Heterozygote x WT","No","2011-05-09","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Neil","Youngson","Queensland Institute of Medical Research","neil.youngson@qimr.edu.au","300 Herston Road, Herston","Brisbane","QLD","Emma","Whitelaw","emma.whitelaw@qimr.edu.au","AO608-611","NLRD_P1260","No"]
[5095,"Lzt-I.1","C57BL/6-Tg(TcraP3A4TcrbP3A4)37Cbn/JWehiApb",null,"Dominant",{"$nulls":25},"transgene insertion P3A4 Tcrb, Francis R Carbone","Tcrb",{"$nulls":10},"Preferential CD8 T cell development resulting in a decreased CD4/CD8 ratio. 80% of peripheral CD8 T cells express the transgenic TCR.","As for homozygous mice","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,"9","brother x sister mating","Yes","2010-04-19","Cryopreserved sperm",100,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","0810007","2009/091","No"]
[3312,"DOM5","B6.DBA1-Tg(Thy1-PP2ACα*L309A)",null,"Recessive",{"$nulls":25},"protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (L309A mutant)","murine Thy1",{"$nulls":11},"Transgene expressed in Brain and Harderian (lacrimal) gland.     Slit eye : 100 % penetrance. Tau phosphorylation in brain vimentin.Authors found a delayed postnatal development and hypoplasia of the gland, causing enophthalmos. To determine why expression of the L309A mutant caused this phenotype, we determined the PP2A subunit composition. We found an altered subunit composition in the transgenic gland that was accompanied by pronounced changes of proteins regulating cell adhesion. Specifically, cadherin and β-catenin were dramatically reduced and shifted to the cytosol. Furthermore, we found an inactivating phosphorylation of the cadherin-directed glycogen synthase kinase-3β.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","6",null,"T6 x C57BL/6","No","2008-06-09",null,0,0,null,null,"true",null,"Juergen","Goetz","Brain and Mind Research Institute","Jgoetz@med.usyd.edu.au",{"$nulls":3},"Juergen","Goetz","Jgoetz@med.usyd.edu.au","K00/1-2009/3/4915","08N032","No"]
[5093,"Iggy","SPIF-1 NEO KO",null,"Recessive","SPIF-1","SPIF-1",{"$nulls":6},"15",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-04-16","Cryopreserved sperm",30,0,null,null,"true",null,"Shaun","Roman","The University of Newcastle","shaun.roman@newcastle.edu.au","Univeristy Drive","Callaghan","NSW","Duangporn","Jamsai","Duangporn.Jamsai@med.monash.edu.au","A-2009-119","107/2009","No"]
[5249,"FGFPC","C57BL/6-Tg(FXN/EGFP)CSars/Apb","C57BL/6-Tg(FXN/EGFP)CSars/Apb","Recessive",{"$nulls":25},"Human FRATAXIN gene","FXN endogenous promoter","Normal",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","21","Hemizygous FXN-EGFP transgene X Hemizygous FXN-EGFP transgene","No","2010-10-20","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Jim","Valados","Murdoch Childrens Research Institute","jim.valados@mcri.edu.au","Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children","Parkville","Victoria","Joseph","Sarsero","joe@sarsero.com","A660","2261/2006","No"]
[{"$nulls":30},"T cell receptor alpha, T cell receptor beta"]
[7276,"B6.RIIa Tg","B6.Fcgr 2a Tg","HOGA","Semi-dominant","Fcgamma r2a","FcgR2a","Normal",{"$nulls":5},"Unknown",{"$nulls":16},"human FcyR2a","human FcyR2a","normal",{"$nulls":9},"normal","not known","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good","12",null,null,"Yes","2013-02-15","Cryopreserved sperm",50,0,null,null,"true",null,"Mark","Hogarth","Burnet","pmhogarth@burnet.edu.au",{"$nulls":3},"Eva","Orlowski","eorlowski@burnet.edu.au","B/BL-2008/195IL",null,"Yes"]
[5524,"Gp130dstat/dstat(Balb/C)","C;(Cg)-Il6st<tm1Ard>/LudApb",null,"Recessive","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Ashley R Dunn","Il6st<tm1Ard>","MGI:2388476","Unknown",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality: * numbers deficient at weaning * ratio of homozygotes normal at E18.Premature death (J:79555): * 6 month life span for males * 8 month life span for femalesDecreased body length: 20-30% shorter trunk length at birth.Decreased body weight: 20-30% lower body weight at birth.Abnormal uterine environment: failure of implantation, blastocysts will develop to term in wild-type recipient femalesFemale infertility: females show no external signs of pregnancy regardless of male genotype.Gastrointestinal haemorrhage: faecal blood at 4 months of age.Abnormal digestive system morphology.Rectal prolapse.Gastrointestinal ulcer:  * caecal ulcers * ulceration of the anorectal regionGgastric ulcer: ulceration of the gastric pylorus at 4 months of age.Large intestinal inflammation: caecal inflammation.Increased susceptibility to induced colitis: * severe erosion of the intestinal epithelium from exposure to 3.5% dextran sodium sulfate. * remain moribund when exposure is ended.Abnormal leukocyte cell number: white blood cell count significantly higher than in controls.Decreased immunoglobulin level.Decreased IgA level: * basal IgA levels are reduced * impaired ability to mount an intestinal IgA response after challenge * basal IgM is normalDecreased IgG level: impaired ability to mount an intestinal IgG response after challenge.Conjunctivitis.Increased susceptibility to parasitic infection: tend to carry higher parasitic loads.Abnormal common myeloid progenitor cell morphology: * colony forming cells elevated in the spleen but not in bone marrow * elevated \"CFU-S\" hematopoietic progenitor cells * hematopoietic progenitors elevated in the liver at E14 relative to controls.Abnormal megakaryocyte morphology.Abnormal thrombopoiesis: * impaired maturation of megakaryocytes to produce platelets * 40% reduction in the number of platelets produced per megakaryocyte.Decreased platelet cell number: platelet count reduced 30%.Decreased megakaryocyte cell number: by 23% in bone marrow.Increased megakaryocyte cell number: numbers in spleen increased 2 fold relative to controls.Skeleton phenotype: trabecular bone volume is normal.Abnormal femur morphology.Decreased diameter of femur: significantly reduced femoral width.Short femur.Abnormal joint morphology.Abnormal joint capsule morphology: * cartilaginous nodules in joint capsules that replace menisci and support cartilage in knee joints * erosion of articular surfaces in older mice.Joint swelling: * of weight bearing joints in 60% of adults * observed by 7 days of age * more severe in males than femalesAbnormal joint mobility: * flexion abnormalities of hindlimbs * reluctance to stand * restricted flexion and extension of ankles and wrists * stiffness of one or more limbsIncreased cell proliferation: proliferative response of fibroblasts in culture to Il6 is increased.Gastrointestinal hemorrhage: fecal blood at 4 months of age.",null,"BALB/c","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-06-14","Cryopreserved sperm",50,0,"Ludwig","ME-79","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","040/2001 $ 304","No"]
[5271,"Vegfb knockout","B6.129T2-Vegfb<tm1Gfk>/QimrApb","Gfk","Recessive","vascular endothelial growth factor B","Vegfb","Nil","VEGF-B, Vrf","MGI:106199 ","vascular endothelial growth factor B; targeted mutation 1, Graham F Kay","Vegfb<tm1Gfk>","MGI:2178819","19",{"$nulls":15},"No",{"$nulls":12},"Corneal vascularization: corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice.Small heart.Decreased heart weight: heart weight is reduced in juveniles but not in early postnatal mice, indicating impaired growth of hearts in the first few weeks after birth.Abnormal cardiovascular system physiology: abnormal reactive hyperemic response to coronary occlusion, with a lower overall flow-debt repayment during the initial 60 sec of reperfusion, although peak hyperemic flow was normal.Increased time of peak ischemic contracture: peak contracture during ischemia is greater, diastolic pressure is elevated during reperfusion and recovered only minimally, and the recovery of contractile function is slightly depressed throughout reperfusion, with the rate-pressure product lower at 30 min compared with controls.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","20",null,"sib-mated homozygous mice","No","2010-10-25","Cryopreserved sperm",45,0,"QIMR",null,"false",null,"Graham","Kay","Queensland Institute of Medical Research","Graham.Kay@qimr.edu.au","300 Herston Rd","Herston","Qld","Graham ","Kay","Graham.Kay@qimr.edu.au","QIMR AEC approval # A0703-601B","QIMR IBC NLRD P786/2010 ","No"]
[7610,"DBM/J","BKS.Cg-Dock7<m> +/+ Lepr<db>/JAusb",null,"Dominant","leptin receptor","Lepr",null,"Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP","MGI:104993","leptin receptor; diabetes","Lepr<db>","MGI:1856009","4",{"$nulls":61},"N/A"]
[4455,null,"B6.129-Rel<tm1Grd>/WehiAnuApb",null,"Recessive","reticuloendotheliosis oncogene","Rel","Unknown","c-Rel","MGI:97897","targeted mutation 1, Steve Gerondakis","Rel<tm1Grd>","MGI:2179622","11",{"$nulls":15},"No",{"$nulls":12},"In mice with an inactivated c-rel gene, whereas development of cells from all hemopoietic lineages appeared normal, humoral immunity was impaired and mature B and T cells were found to be unresponsive to most mitogenic stimuli. Phorbol ester and calcium ionophore costimulation, in contrast to certain membrane receptor-mediated signals, overcame the T cell-proliferative defect, demonstrating that T cell proliferation occurs by Rel-dependent and -independent mechanisms.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-20","Cryopreserved sperm",120,0,"ANU","092","false",null,"Steve","Gerondakis","Walter and Eliza Hall Institute of Medical Research","gerondakis@burnet.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","A.BS.01.09","N/A","No"]
[5199,"tghFS288(mFS WT)","Transgenic Human Follistatin 288 on mouse wildtype follistatin background",null,"Dominant",{"$nulls":25},"Human follistatin-288 splice variant","endogenous human promoter","unknown",{"$nulls":9},"Unknown","Hemizygous: normal Note: An abnormal phenotype is not observed until these mice are bred onto a mouse follistatin knockout background","129 x C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2010-08-04","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Jane","Girling","MIMR-PHI Institute of Medical Research","jane.girling@monash.edu","Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, 246 Clayton Road","Clayton","Victoria","Jane","Girling","jane.girling@monash.edu","MMCA 2009/37(BC)","N33/2006","No"]
[5094,"gBT-I.1xA/J","A.B6-Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn/Apb",null,"Dominant",{"$nulls":25},"transgene insertion L118-1, Francis R Carbone","2 kb fragment of the H-2Kb and a 700 bp fragment including the Igh enhancer",{"$nulls":10},"Normal","Normal","A/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10","7","brother x sister mating","Yes","2010-04-19","Cryopreserved sperm",50,0,null,null,"false",null,"Francis","Carbone","The University of Melbourne","fcarbone@unimelb.edu.au","Dept Microbiology & Immunology","Parkville","Victoria","Gayle","Davey","daveyg@unimelb.edu.au","0911339","2009/091","No"]
[5185,"MMP13KO RAG1KO FVBn","FVB/N(Cg)-Mmp13<tm1.1Werb> Rag1<tm1>/Apb",null,"Recessive","matrix metallopeptidase 13","MMP13","Nil","Clg, collagenase-1, Collagenase-3, interstitial collagenase, MMP-13, Mmp1","MGI:1340026","matrix metallopeptidase 13 Knockout","MMP13KO",null,"9",{"$nulls":28},"Increased width of hypertrophic chondrocyte zone: * the hypertrophic zone is expanded in the tibia and metatarsals, at E17 and 1 week after birth, respectively, however by 12 weeks of age the size of the hypertrophic zone is similar to wild-type. * chondrocytes proliferate and differentiate normally but accumulate in the most terminally differentiated hypertrophic state. * establishment of the primary ossification centers is normal.Abnormal cancellous bone morphology: * the amount of trabecular bone is increased in the tibia and metatarsals by 3 weeks or 1 week of age, respectively, however by 1 year of age the amount of trabecular bone was similar to wild-type. * the organization of the trabecular bone is also irregular.OA was surgically induced in the knees of MMP-13-knockout mice. No difference between wildtype and KO mice for aggrecan loss or cartilage erosion at 4 weeks. here was less tibial cartilage erosion in knockout mice than in wild-type mice at 8 weeks. Cartilaginous osteophytes were larger in knockout mice at 4 weeks, but by 8 weeks osteophyte maturity and size were no different from those in wild-type mice. Articular chondrocyte hypertrophy with positive type X collagen and DIPEN staining occurred in both wild-type and knockout mouse joints. Authors conclude Chondrocyte hypertrophy is not regulated by MMP-13 activity in this model and does not in itself lead to cartilage erosion. MMP-13 deficiency can inhibit cartilage erosion in the presence of aggrecan depletion, supporting the potential for therapeutic intervention in established OA with MMP-13 inhibitors.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","10",null,null,"No","2010-07-28","Cryopreserved sperm",50,0,null,null,"false",null,"Erik","Thompson","St Vincent's Institute","rik@medstv.unimelb.edu.au","9 Princes Street, Fitzroy","Melbourne","Victoria","Erik","Thompson","rik@medstv.unimelb.edu.au","SVH AEC BGMML 071","SVH IBC 149","No"]
[5424,"PRrtTAKI","129.Cg-Pgr<tm3(rtTA2S*M2)Lyd>/Apb",null,"Dominant","progesterone receptor","Pgr",null,"NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 3, John P Lydon","Pgr<tm3(rtTA2S*M2)Lyd>","MGI:3768562","9",{"$nulls":15},"Yes",{"$nulls":12},"Abnormal female reproductive system morphology: authors state that the phenotype is identical to that of Pgr<tm1Bwo> homozygotes.Female infertility: authors state that the phenotype is identical to that of Pgr<tm1Bwo> homozygotes.","Unknown","crossed within line","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"4 @ Host institution","All genotypes are viable and fertile, any combination can be used. We often cross Male Het with Female Hom","No","2011-02-09","Cryopreserved sperm",50,0,"ABR - Moss Vale",null,"false",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Anita","Ledger","a.ledger@garvan.org.au","09/35","546/2002","No"]
[7685,"Notch4null","B6(Cg)-Notch4<tm1(KOMP)Vlcg>/Apb",null,"Recessive","notch 4","Notch4","Nil","Int3, Int-3, N4","MGI:107471","notch 4; targeted mutation 1, Velocigene","Notch4<tm1(KOMP)Vlcg>","MGI:4842905","17",{"$nulls":28},"Mild delay in retinal angiogenesis","Normal","C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good","7 generations",null,null,"No","2014-05-22","Cryopreserved sperm",50,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Alexander","James","a.james@victorchang.edu.au","12/33","N21/2012","No"]
[5425,"Tpcn1∆","129S5/SvEvBrd-Tpcn1<Gt(OST359423)Lex>/Apb",null,"Dominant","two pore channel 1","Tpcn1","Unknown",null,"MGI:2182472","two pore channel 1; gene trap OST359423, Lexicon Genetics","Tpcn1<Gt(OST359423)Lex>","MGI:3529820","5",{"$nulls":15},"No",{"$nulls":12},"Unknown","Unknown","129S5/SvEvBrd","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"4 @ Garvan","We keep Homozygous","No","2011-02-09","Cryopreserved sperm",35,0,"ABR - Moss Vale",null,"false",null,"Chris","Ormandy","Garvan Institute","c.ormandy@garvan.org.au",{"$nulls":3},"Anita","Ledger","a.ledger@garvan.org.au","09/35","3010/2008","No"]
[5428,"TnI.1; cTnIwt.1","C57BL/6-Tg(Myh6-TNNI3*wt)1Chs/Apb",null,"Dominant",{"$nulls":25},"transgene insertion wild type 1, Christopher Semsarian","cardiac specific mouse αMHC promoter (alpha myosin heavy chain)","50% of endogenous (hemizygous)",{"$nulls":9},"Unknown","Indistinguishable from non-transgenic wild type C57BL/6 mice ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,"17, of which 13 have been maintaned as homozygous","Homozygous transgenic x homozygous transgenic sibs","No","2011-02-10","Cryopreserved sperm",45,0,null,null,"false",null,"Christopher","Semsarian","Centenary Institute","C.Semsarian@centenary.org.au","Locked Bag No. 6","Newtown","NSW","Tatiana","Tsoutsman","T.Tsoutsman@centenary.org.au","K75/12-2009/3/5185","942/2002","No"]
[5294,"CZ-SOD ; B6.huSOD1.Tg (TD)","C57BL/6-Tg(H2-K<b>-SOD1)Apb",null,"Dominant",{"$nulls":25},"human superoxide dismutase 1, soluble","H2-K<b>",{"$nulls":10},"These mice contain human CuZn superoxide dismutase (SOD1) with a hemagglutinin epitope tag expressed from the mouse H-2Kb (MHC Class I) promoter. The antioxidant enzyme is expressed in most nucleated cells, which should therefore be protected from (superoxide anion) oxidative injury. This has been demonstrated using pancreatic islets isolated from the transgenic mice.The mice show no overt phenotype.  Phenotype does not differ from a wildtype of the same genetic background.",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","10",null,null,"No","2010-10-29","Cryopreserved sperm",50,0,"St V","211","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML#21","094","No"]
[5253,"Hoxb7/GFP","B6;CBA-Tg(Hoxb7-EGFP)33Cos/MarpApb",null,"Dominant",{"$nulls":25},"transgene insertion 33, Franklin Costantini","Hoxb7","High level expression",{"$nulls":9},"GFP is too strong in homozygote state and embryos don't survive","Normal.GFP expression controlled by the activity of the HoxB7 promoter.GFP expressed in ureteric epithelium of the kidney, snout of pup and in regions of the brain.","(C57BL/6 x CBA)F2","No","Unknown","Yes","No","Unknown","Yes","No","Good",{"$nulls":3},"No","2010-10-20","Cryopreserved sperm",90,0,"Monash",null,"false",null,"Georgina","Caruana","Monash University","georgina.caruana@monash.edu",{"$nulls":3},"Georgina","Caruana","georgina.caruana@monash.edu","SOBSA2007_89BC","PC1-N29/02","No"]
[7328,"ENU25:009:BTK","C57BL/6NCrlAnu-Btk<m2Anu>/AnuApb","C57BL/6NCrlAnu-Btk<m2Anu>/AnuApb","Recessive","Bruton agammaglobulinemia tyrosine kinase","Btk","Unknown","Bruton's tyrosine kinase, X-linked immune deficiency, xid","MGI:88216","Bruton agammaglobulinemia tyrosine kinase; mutation 2, The Australian National University","Btk<m2Anu>","MGI:5563503","X","ENSMUSG00000031264","ENSMUST00000033617","Btk-001","454","614","A to G","ENSMUSE00001191399","6","152","Tyrosine to Histidine",{"$nulls":4},"ACCATCCTTGCTTCTGGATTGATGGACAGTATCTCTGCTGCTCTCAGACAGCCAAGAATGC","Unknown",{"$nulls":12},"Mild BTK phenotype. Normal % peripheral B cells, increased numbers of immature B cells. Increased IgM expression on mature B cells.","Hemizygous phenotype same as homozygous females","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Unknown","Yes","No","Excellent",null,"G3",null,"No","2013-05-01","Cryopreserved sperm",37,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"Yes"]
[5486,"ENU20FLT3-ITD:G1(#37)","ENU20FLT3-ITD:G1",null,"Dominant","FMS-like tyrosine kinase 3","Flt3","Increased","CD135, Flk-2, Flk2, Flt-3","MGI:95559","FMS-like tyrosine kinase 3; targeted mutation 1, D Gilliland","Flt3<tm1Dgg>","MGI:3763385","5",{"$nulls":15},"Yes",{"$nulls":12},"Accelerated onset of Acute Myeloid leukaemia.","Accelerated onset of Acute Myeloid leukaemia.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"G1",null,"No","2011-04-19","Cryopreserved sperm",10,0,"ANU",null,"true",null,"Tom","Gonda","Diamantina Institute","t.gonda@uq.edu.au",{"$nulls":3},"Robert","Tunningley","robert.tunningley@anu.edu.au","N/A","N","No"]
[7322,"Pdx1-cre","B6(Cg)-Tg(Ipf1-cre)1Tuv/AusbAnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 6, David A Tuveson","Ipf1","Islet cells of pancreas",{"$nulls":9},"Normal.Islet cells express Cre recombinase","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-04-20","Cryopreserved sperm",66,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Ayla","Lorenzo","ayla.lorenzo@anu.edu.au","N/A","N/A","No"]
[4881,"Bc.Rag1/Gal KO","C.B6-Rag1<tm1Mom> Ggta1<tm1>/Apb",null,"Recessive","recombination activating gene 1","Rag1","Nil","Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":15},"No",{"$nulls":12},"Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.All blood/tissue samples lack Gal expression.Cortical cataracts developed in all GalT-/- mice at 4-6 weeks of age.Mice are deficient in mature B and T cells.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-09-28","Cryopreserved sperm",83,0,"St V","042","false",null,"Peter","Cowan","St Vincent's Hospital Melbourne","Peter.Cowan@svhm.org.au",{"$nulls":3},"Peter","Cowan","Peter.Cowan@svhm.org.au","BGMML 90","94","No"]
[7323,"ENU19:B6:Trim7","C57BL/6-Trim7<m1Anu>/AnuApb","C57BL/6-Trim7<m1Anu>/AnuApb","Recessive","tripartite motif-containing 7","Trim7",null,null,"MGI:2137353","mutation 1, The Australian National University","Trim7<m1Anu>",null,"11","ENSMUSG00000040350","ENSMUST00000109213","Trim7-001","124","370","A to G","ENSMUSE00000679460","2","44","Asparagine to Aspartic acid",{"$nulls":4},"TGCTGTCCCGGGAAGTGACACAGAAACAGAATGAGAACCTGGCCCAGCTGGAGGGTGAGAT",{"$nulls":13},"Unknown",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-04-22","Cryopreserved sperm",20,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","A2011/025",null,"No"]
[6592,"GQI","B6.(Cg)-Tg(Myh6-Gnaq*)Wjk/Vccr",null,"Dominant",{"$nulls":26},"murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter","heart muscle",{"$nulls":9},"Viable, fertile",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-29",null,0,0,"Victor Chang",null,"true",null,"Michael","Feneley","Victor Chang Cardiac Research Institute","mfeneley@stvincents.com.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","N/A","NLRD 3026/2010","No"]
[5051,"NOD.pIgR-/- R2 N15","NOD.B6(pIgR-D1Mit348)N15-Pigr<tm1Rast>",null,"Recessive","polymeric immunoglobulin receptor","Pigr","Unknown",null,"MGI:103080",null,null,"MGI:2651659","1",{"$nulls":15},"No",{"$nulls":12},"Like B6.pIgR-/- mice (described in Uren et al., 2003), this mouse strain does not produce functional pIgR, and therefore lacks IgA in secretions and has increased levels of IgA in serum. The incidence of diabetes in female mice is about 40% after 43-weeks, which is significantly lower than the incidence of diabetes in NOD/Lt mice in our facility (~60% at 43-weeks of age).","Like B6.pIgR+/- mice, heterozygotes of this mouse strain produce functional pIgR, and have normal levels of IgA in secretions, however the levels of IgA in serum are intermediate between NOD/Lt and NOD.pIgR-/-. The incidence of diabetes has not been tested in heterozygotes of this mouse strain.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","15","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm",45,0,null,null,"true",null,"Richard","Strugnell","The University of Melbourne","rastru@unimelb.edu.au",{"$nulls":3},"Kim","Simpfendorfer","k.simpfendorfer@pgrad.unimelb.edu.au","0703883","NLRD 2278/2007","No"]
[5049,"NOD.pIgR-/- R1 N10","NOD.B6(D1Mit495-D1Mit348)N10-Pigr<tm1Rast>",null,"Recessive","polymeric immunoglobulin receptor","Pigr","Unknown",null,"MGI:103080",null,null,"MGI:2651659","1",{"$nulls":15},"No",{"$nulls":12},"Like B6.pIgR-/- mice (described in Uren et al., 2003), this mouse strain does not produce functional pIgR, and therefore lacks IgA in secretions and has increased levels of IgA in serum. The incidence of diabetes in female mice is 60-65% after 43-weeks, which is consistently, but not significantly higher than the incidence of diabetes in NOD/Lt mice in host facility (50-60% at 43-weeks of age). The incidence of diabetes in mice of this strain is not significantly different from NOD/Lt males in our facility.","Like B6.pIgR+/- mice, heterozygotes of this mouse strain produce functional pIgR, and have normal levels of IgA in secretions, however the levels of IgA in serum are intermediate between NOD/Lt and NOD.pIgR-/-. The incidence of diabetes of heterozygote females is 63% at 40-weeks of age.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm",45,0,null,null,"true",null,"Richard","Strugnell","The University of Melbourne","rastru@unimelb.edu.au",{"$nulls":3},"Kim","Simpfendorfer","k.simpfendorfer@pgrad.unimelb.edu.au","0703883","NLRD 2278/2007","No"]
[5050,"NOD.pIgR-/- R1 N14","NOD.B6(D1Mit495-D1Mit348)N14-Pigr<tm1Rast>",null,"Recessive","polymeric immunoglobulin receptor","Pigr","Unknown",null,"MGI:103080",null,null,"MGI:2651659","1",{"$nulls":15},"No",{"$nulls":12},"Like B6.pIgR-/- mice (described in Uren et al., 2003), this mouse strain does not produce functional pIgR, and therefore lacks IgA in secretions and has increased levels of IgA in serum. The incidence of diabetes has not been tested for this strain but it is expected that it would be the same as the NOD.pIgR-/- R1 N10 strain (female mice is 60-65% after 43-weeks, the incidence of diabetes in NOD/Lt mice in host facility is 50-60% at 43-weeks of age). ","Like B6.pIgR+/- mice, heterozygotes of this mouse strain produce functional pIgR, and have normal levels of IgA in secretions, however the levels of IgA in serum are intermediate between NOD/Lt and NOD.pIgR-/-. ","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","14","8","Hom x Hom","No","2010-02-26","Cryopreserved sperm",45,0,null,null,"true",null,"Richard","Strugnell","The University of Melbourne","rastru@unimelb.edu.au",{"$nulls":3},"Kim","Simpfendorfer","k.simpfendorfer@pgrad.unimelb.edu.au","0703883","NLRD 2278/2007","No"]
[7325,null,"SJL-Tfrc<ASAM121957>/Apb",null,"Dominant","transferrin receptor","Tfrc",null,"2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr","MGI:98822",null,"Tfrc<ASAM121957>",null,"16","ENSMUSG00000022797","ENSMUST00000023486","Tfrc-001","218","358","T to G","ENSMUSE00000130494","3","73","Leucine to Arginine",{"$nulls":4},"TGGAAGACTCTGCTTTGCAGCTATTGCACTAGTCATTTTCTTCTTGATTGGATTCATGAGT",{"$nulls":13},"Severe microcytosis associated with erythrocytosis and normochromia. The homozygous are not viable.","Microcytosis associated with erythrocytosis and normochromia","SJL/J","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-04-23","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7327,"B6.SJL","B6.SJL-Ptprc<a> Pep3<b>/BoyJAnuApb",null,"Recessive",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","Unknown","Normal",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-04-24","Cryopreserved sperm",10,0,"ANU","029","false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Shelley","Bolton","shelley.Bolton@anu.edu.au","N/A",null,"No"]
[7114,null,"ENU10B6043a",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Increased susceptibility to infection with Ectromelia.","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-10-29","Cryopreserved sperm",47,0,"ANU",null,"false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","A2011/33",null,"No"]
[7110,"ROS-iePLA","ROS-iePLA",null,"Dominant",{"$nulls":25},"ROS-iePLA",{"$nulls":11},"Mouse express GFP","Mouse express GFP","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-10-19","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nicolas","Plachta","Australian Regenerative Medicine Institute","nicolas.plachta@monash.edu",{"$nulls":3},"Nicolas","Plachta","nicolas.plachta@monash.edu","MARP/2011/065",null,"No"]
[5747,"Eddie",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5753,"Emx1/gad67",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7351,"uGFP","C57BL/6-Tg(UBC-GFP)30Scha/JWehiAnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 30, Brian Schaefer","uman ubiquitin C promoter",{"$nulls":10},"Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These mice express GFP in all tissues examined. Expression levels vary between certain hematapoetic cell types. GFP expression is uniform within a cell type lineage and remains constant throughout development. T cells have a 2-fold higher GFP expression than CD19+B220+ B cells or peripheral blood cells. Leukocytes and red blood cells from homozygous transgenic mice fluoresce at approximately twice the level of cells from hemizygous mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-06-07","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7329,"ENU19 WT:029:a:B6:F3","C57BL/6JAnu-Gucd1<m1Anu>/Anu",null,"Recessive","guanylyl cyclase domain containing 1","Gucd1","Unknown","1110038D17Rik","MGI:1916028","mutation 1, The Australian National University","Gucd1<m1Anu>",null,"10","ENSMUSG00000033416",null,null,"536","721","G to C","ENSMUSE00000226356","5","179","Arginine to Proline",{"$nulls":4},"TACTCCCAGTGGCCACCGCTGCTTCTGCCGCACCCCCGACTACCAAGGCCACTTCATCGTC","Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-05-01","Cryopreserved sperm",50,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7250,"ENU18China:68b","C57BL/6JAnu-Ptpn6<m2Anu>/AnuApb","C57BL/6JAnu-Ptpn6<m2Anu>/AnuApb","Dominant","protein tyrosine phosphatase, non-receptor type 6","Ptpn6 ","Reduced","hcp, Hcph, Ptp1C, SHP-1, Spin","MGI:96055","protein tyrosine phosphatase, non-receptor type 6; mutation 2, The Australian National University","Ptpn6<m2Anu>","MGI:5563434","6","ENSMUSG00000004266","ENSMUST00000112484","Ptpn6-002","4","205","C to T","ENSMUSE00000691827","1","2","Valine to Methionine",{"$nulls":4},"ATGGTGAGGTGGTTTCACCGGGACCTCAGCGGGCC",{"$nulls":13},"Reduced IgM expression on mature B cells. Reduced percentage of mature B cells. Adult homozygous mice are healthy.","Mild reduction in the percent of mature B cells and mild reduction of IgM on mature B cells","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"7","homozygous x homozygous","No","2012-12-13","Cryopreserved sperm",47,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"No"]
[7135,"Moe","B6129S5-Cma1<tm1Lex>/TAC/Ausb",{"$nulls":3},"mMCP5",null,null,"MGI:96941",{"$nulls":34},"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","2918","true",null,"Philip","Hansbro",{"$nulls":8},"N/A","N/A","No"]
[7130,"SIRT5b","Sirtuin5 #38/Ausb",null,"Recessive",null,"Sirt5",{"$nulls":35},"None",null,"C57BL6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","2905","true",null,"Nigel","Turner","The University of New South Wales","n.turner@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7141,"PAR1","Protease receptor 1 deficient mice/Ausb",{"$nulls":3},"PAR1",null,null,"MGI:101802",{"$nulls":32},"Slow breeders; they may have a reduced innate immune response.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","2956","true",null,"Jonathan","Erlich",{"$nulls":8},"N/A","N/A","No"]
[7155,"NMNAT3","B6.J.B6D2-Tg(CAG-Nmnat3)1Ara/Ausb",{"$nulls":3},"NMNAT3",null,null,"MGI:1921330",{"$nulls":34},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3028","true",null,"Nigel","Turner",{"$nulls":8},"N/A","N/A","No"]
[7164,"PUMA","C57BL/6-Bbc3<tm1Ast>/WEHIAusb/Ausb",{"$nulls":3},"Bbc3",null,null,"MGI:2181667",{"$nulls":32},"decreased sensitivity to induced cell death",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3049","true",null,"Chris","Ormandy",{"$nulls":8},"N/A","N/A","No"]
[7167,"GFP-LC3","B6.B6D2-Tg(CAG-RGFP/LC3)53Nmz/NmzRbrc/Ausb",{"$nulls":3},"LC3gFP",null,null,"MGI:3759813",{"$nulls":34},"C57BL/6JJcl","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3052","true",null,"Trevor","Biden",{"$nulls":8},"N/A","N/A","No"]
[7168,"ATG7","B6.Cg-ATg7<tm1Tchi>/Rbrc/Ausb",{"$nulls":3},"ATG7",null,null,"MGI:3587769",{"$nulls":34},"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3053","true",null,"Trevor","Biden",{"$nulls":8},"N/A","N/A","No"]
[7174,"ApoDnullAPP","ApoDnull x B6.Cg-Tg(APPswePSEN1dE9)85Dbo/JAusb",null,"Dominant",null,"ApoD,APP,PSEN1",{"$nulls":6},"Unknown",{"$nulls":28},"Early onset of Alzheimer's disease.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"Moss Vale","3063","true",null,"Brett","Garner","Garvan Institute","dont@know.edu",{"$nulls":6},"N/A","N/A","No"]
[7693,"Tpbpa-Cre","C57BL/6-Tg(Tpbpa-cre,-EGFP)5Jcc",null,"Dominant",{"$nulls":25},"transgene insertion 5, James C Cross","trophoblast specific protein alpha",{"$nulls":10},"Normal","Normal","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2014-05-26","Cryopreserved sperm",50,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","12/33","N21/2012","No"]
[7186,"Spns2","C57BL/6DnkSpns2<tm1a(KOMP)Wtsi> (?)/Ausb",{"$nulls":3},"Spns2",null,null,"MGI:2384936 ",{"$nulls":32},"Absent pinna reflex,abnormal corneal vascularisation,abnormal braistem auditory evoked potencial,decrease leukocyte cell number,altered peripheral blood lymphocytes LSRII,decreased circulating glucose level,abnormal eye pigmenttation,increase bone mineral",null,"BL/6NTac/Den,BL/6J-TTyrcBrd;BL/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3107","true",null,"Peter","Croucher",{"$nulls":8},"N/A","N/A","No"]
[7187,"R-FLPo","unknown/Ausb",null,"Dominant",{"$nulls":39},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","3114","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[7331,"ADAR1 +/-","B6.129-Adar<tm1Phs>/TacStvApb",null,"Dominant","adenosine deaminase, RNA-specific","Adar","Nil","ADAR1, mZaADAR","MGI:1889575","adenosine deaminase, RNA-specific; targeted mutation 1, Peter H Seeburg ","Adar<tm1Phs>","MGI:3029789","3",{"$nulls":28},"Homozygous animals die at E11.5.","Heterozygous animals normal and healthy","C57BL/6","No","Yes","Yes","No","Yes","Yes","No","Excellent","more than 6","unknown/not collected","+/- to +/-","No","2013-05-09","Cryopreserved sperm",30,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","SABC025","IBC168","No"]
[7200,"Thy1-YFP","B6.Cg-Tg(Thy1-YFP)HJrs/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion H, Joshua R Sanes","mouse Thy1",{"$nulls":11},"Hemizygotes will express YFP in motor and sensory neurons and cortical layer V pyramidal cells.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-11-05",null,0,0,"Moss Vale","3265","true",null,"Frederick","Walker","The University of Newcastle","rohan.walker@newcastle.edu.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[5585,"202 KO B57",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7204,"AR2.3-tg","B6(Cg)-Tg(Col1a1*2.3-Ar)/Apb",null,"Dominant",{"$nulls":25},"AR2.3-tg","2.3kb fragment of the rat type 1 alpha 1 collagen gene",{"$nulls":10},"Low bone turnover phenotype with compromised bone quality and strength.","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">10",null,null,"No","2012-11-07","Cryopreserved sperm",50,0,null,null,"false",null,"Rachel","Davey","The University of Melbourne","r.davey@unimelb.edu.au",{"$nulls":3},"Rachel","Davey","r.davey@unimelb.edu.au","A2010/03811","04561","No"]
[6922,"Recql4+/-","C57BL/6-Recql4<tm2 2272Arte>/Apb",null,"Dominant","RecQ protein-like 4","Recql4","Nil",null,"MGI:1931028","Recql4 germ-line knockout",null,null,"15",{"$nulls":28},"homozygous lethal at or before E10.5","apparently normal - viable, fertile","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","generated on pure C57Bl/6 so not backcrossed. Only maintained on C57",null,"+/- to +/-","No","2012-06-27","Cryopreserved sperm",64,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":3},"Carl","Walkley","cwalkley@svi.edu.au","AEC 044/10","IBC168, GBNML #219","No"]
[7203,"Vdr flox","B6-Vdr<tm1Pcn>/Apb",null,"Dominant","vitamin D (1,25-dihydroxyvitamin D3) receptor","Vdr","Normal","Nr1i1","MGI:103076","vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Pierre Chambon","Vdr<tm1Pcn>","MGI:3663379","15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">10",null,null,"No","2012-11-07","Cryopreserved sperm",46,0,null,null,"false",null,"Rachel","Davey","The University of Melbourne","r.davey@unimelb.edu.au",{"$nulls":3},"Rachel","Davey","r.davey@unimelb.edu.au","A2010/04080","04561","No"]
[7034,null,"ENU22 Bcl2:015",null,"Dominant","unknown","unknown",{"$nulls":6},"Unknown",{"$nulls":28},"High Platelet phenotype. Phenotyping technique by Advia. Not: Even though sperm freezing shows medium to low concentration and motility these mice breed extremely well.","Normal.Not: Even though sperm freezing shows medium to low concentration and motility these mice breed extremely well.","C57BL/6NCrl","Unknown","Unknown","Unknown","Unknown","Yes","Yes","No","Excellent","Mice will be frozen at G4",null,"Affected by B6","No","2012-07-31","Cryopreserved sperm",45,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","A211/41",null,"No"]
[7027,"CAG-H2B-GFP","C57BL/6N-Tg(CAG-H2<b>/GFP)/MarpApb",null,"Recessive",{"$nulls":25},"histocompatibility-2","chicken beta actin (CAG)",{"$nulls":10},"Expresses H2B-GFP from CAG promoter","Expresses H2B-GFP from CAG promoter","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2012-07-24","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Nicolas","Plachta","Monash University","nicolas.plachta@monash.edu",{"$nulls":3},"Nicolas","Plachta","nicolas.plachta@monash.edu","MARP/2011/167","PC1-N32/11","No"]
[5587,"49.1A",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[7037,"zeta-SV129 390","129Sv-Ywhaz<Gt(OST405390)Lex>/Apb",null,"Recessive","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide","Ywhaz","Nil","1110013I11Rik, 14-3-3 zeta","MGI:109484","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST405390, Lexicon Genetics","Ywhaz<Gt(OST405390)Lex>",null,"15",{"$nulls":28},"Infertile, reduced survival of KO pups at 21 days","None","129Sv/B6","Yes","No","Yes","Yes","No","Yes","Yes","Good","N/A",null,"het x het","No","2012-08-06","Cryopreserved sperm",50,0,null,null,"false",null,"Angel","Lopez","SA Pathology","Angel.lopez@health.sa.gov.au",{"$nulls":3},"Hayley","Ramshaw","hayley.ramshaw@health.sa.gov.au","M/236/11","13/2002","No"]
[4807,"Jayne","ENU8BAT:023",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",45,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Moira","O'Bryan","moira.O'Bryan@med.monash.edu.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[5175,null,"ENU15China:001b",null,"Recessive","Unknown","Unknown","Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Increased Germinal Centre B cells in unimmunised mice","Unknown","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-07-12","Cryopreserved sperm",10,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","APF.14.08","N/A","No"]
[{"$nulls":30},"transgene insertion 1, Mark M Davis"]
[7071,"APN209","C57Bl/6N(Ag)-Rabl2<tm1(KOMP)Wtsi>/Marp",null,"Recessive","RAB, member of RAS oncogene family-like 2","Rabl2","Unknown","1110031N17Rik, Rabl2a","MGI:1915958 ","RAB, member of RAS oncogene family-like 2; targeted mutation 1, Wellcome Trust Sanger Institute ","Rabl2<tm1(KOMP)Wtsi>/Marp ","MGI:4431454","15",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2012-08-30","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MAS/MAS 2010/08","PC1 N09/07","No"]
[4854,"Shepherd","ENU6AT:045",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":16},"transgene insertion 3, Christopher C Goodnow","Rat insulin promoter","Expression of the inserted sequence specifically to pancreatic islet beta cells",{"$nulls":9},"Male infertility. Mutant found in HEL:TCR ENU library.HEL:TCR transgenes not required for mutant phenotype",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[4853,"Taily ; ENU8CAT:006","CBA;B6JSfdAnu-Katnb1<taily>/AnuApb",null,"Recessive","katanin p80 (WD40-containing) subunit B 1","Katnb1","Unknown","KAT","MGI:1921437","katanin p80 (WD40-containing) subunit B 1; taily","Katnb1<taily>","MGI:5428740","8","ENSMUSG00000031787","ENSMUST00000034239","Katnb1-201","700","972","G to T","ENSMUSE00000212968","9","234","Valine to Phenylalanine",{"$nulls":4},"TGAGCTGCATTGAAGGGGAGCCCGGGCCCGTCAGGAGTGTCCTCTTCAACCCCGACGGCTG","Yes",{"$nulls":12},"Male infertility. Reproductive system phenotype:\t• number of Sertoli cells, spermatogonia and spermatocytes are similar to controls.Small testis:\t• testes from 8-12 week old homozygous mice are 18.7% smaller than controls.Oligozoospermia:\t• epididymes from mutant males contain significantly lower sperm counts.Abnormal sperm flagellum morphology:\t• flimsy or absent outer dense fibers.Abnormal sperm axoneme morphology:• missing central microtubules and hemi-axenomes are present.Globozoospermia:\t• abnormally shaped spermatid heads.• all sperm in the cauda epididymis have abnormally shaped heads.Abnormal spermatid morphology:• ~30% fewer spermatids (round and elongating) compared to controls.Abnormal manchette morphology:• mutant spermatids exhibit constricted perinuclear rings, nuclear distortion and abnormally long microtubules extending in to the distal cytoplasm.• although the manchettes eventually resolved, the removal of manchettes was delayed at step 13.Abnormal male meiosis:\t• abnormal male meiotic cells appear at metaphase-anaphase; many cells are stalled in late anaphase in mutant males.• reduction in spermatid number is due to a decrease in the number of cells exiting meiosis.• apoptotic cells are present in the stage XII and stage I tubules where final events of meiosis occur.• telophase cells with prominent midbody microtubules are seen in testes from mutant male mice• binucleated haploid spermatids frequently appear.Abnormal meiotic spindle morphology:• metaphase spindles are more densely populated with microtubules and project from the poles at a wider angle than controls pole to pole measurements in metaphase spindles are longer than controls.Increased Sertoli cell phagocytosis:\t• 36-fold increase in the number of spermatozoa being phagocytosed by Sertoli cells in stages IX-X1 tubules.Asthenozoospermia:• all sperm in the cauda epididymis display compromised motility, with very few capable of forward (progressive) motility.",null,"C57BL/6 x CBA x C57BL/10BR","Yes","Yes","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2009-09-24","Cryopreserved sperm",175,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","Moira.O'Bryan@monash.edu",{"$nulls":3},"Vicki","Adams","victoria.adams@anu.edu.au","J.APF.13.08","N/A","No"]
[4911,"Per-gAB","C57BL/6-Gzma<tm1Simn> Gzmb<tm1Ley> Prf1<tm1Sdz>/AnuApb",null,"Recessive","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"Yes",{"$nulls":12},"Increased sensitivity to induced morbidity/mortality: West Nile Virus-infected triple homozygotes display prolonged mean survival time (MST) but significantly increased mortality (50%) relative to either wild-type (29%) or Prf1<tm1Sdz> (18%) mice.Immune system phenotype: triple homozygotes develop a normal contact hypersensitivity (CHS) response (based on increase in ear thickness) to trinitrophenyl (TNP) relative to wild-type mice.Increased susceptibility to parasitic infection: decreased clearance and survival after infection with Trypanosoma cruziIncreased susceptibility to viral infection: triple homozygotes display increased susceptibility to West Nile flavivirus (WNV) infection relative to wild-type. Triple mutants show a higher level of infectious virus in brain relative to wild-type or Prf1<tm1Sdz> mice at the same time point",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-10-12","Cryopreserved sperm",50,0,"ANU","018","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[8703,"ASD752:Ssbp4","C57BL/6NCrlAnu-Ssbp4<em1Anu>/Anu",null,"Recessive","single stranded DNA binding protein 4","Ssbp4",null,"1210002E11Rik","MGI:1924150",{"$nulls":3},"8",{"$nulls":28},"Unknown","unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-16","Cryopreserved sperm",92,0,"ANU","752","true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[7335,null,"SJL/Mrit<MRI26194>",null,"Dominant","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Pre and Perinatal mortality with Jaundice, enlarge spleen and fragmented red blood cells","Heterozygous mice display a microcytic anaemia with increase osmotic fragility and splenomegaly","SJL/J","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-05-14","Cryopreserved sperm",70,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7479,"dll1","C57BL/6J-Dll1<tm1Mjo>","C57BL/6J-Dll1<tm1Mjo>","Recessive","delta-like 1 (Drosophila)","Dll1","Nil","Delta1","MGI:104659","delta-like 1 (Drosophila); targeted mutation 1, Michael J Owen","Dll1<tm1Mjo>","MGI:3044907","17",{"$nulls":15},"No",{"$nulls":12},"None","None","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10","0","D1flox homozygous intercross","No","2013-11-13","Cryopreserved sperm",80,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","Garvan Institute of Medical Research/St Vincent’s AEC 12/33","N21/2012","No"]
[5501,"A33crePR2 ","C57BL/6-Gpa33<tm1(cre)Ern>/LudApb",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,"A33 antigen","MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 1, Matthias Ernst","Gpa33<tm1(cre)Ern>",null,"1",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Cre recombinase expressed in the intestinal epithelium.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-05-09","Cryopreserved sperm",50,0,"Ludwig","ME-132","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","040/2001 & 304","No"]
[6765,"A33:Lgp130YFKQ","CBA;129-Tg(Gpa33-Il6*)6Ern/LudApb",null,"Dominant",{"$nulls":25},"transgene insertion 6 Matthias Ernst","glycoprotein A33 (transmembrane)",{"$nulls":10},"Unknown","Unknwon","CBA/129","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2011-12-16","Cryopreserved sperm",50,0,"Ludwig","ME-178","false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","040/2001 & 1451/2004","No"]
[6923,"ERT2/Pten/Gp130F (Black); A33(CreERT2)/Pten loxP/Gp130y757F (ME-276)","STOCK Gpa33<tm1(cre)Ern> Il6st<tm1Ern> Pten<tm2Mak>/Lud",null,"Dominant","glycoprotein A33 (transmembrane)","Gpa33",null,"A33 antigen","MGI:1891703","glycoprotein A33 (transmembrane) targeted mutation 1, Matthias Ernst","Gpa33<tm1(cre)Ern>",null,"1",{"$nulls":28},"Unknown","Unknown","Mixed 129 and C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2012-06-27",null,0,0,"Ludwig","ME-276","true",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"009/09","ME-276","No"]
[8694,"C57/Bl6 Gmcsf-/- Cish-lacZ/lacZ","C57BL/6-Csf2<tm1Ard> Cish<tm1>/",null,"Recessive","colony stimulating factor 2 (granulocyte-macrophage)","Csf2","Nil","Csfgm, Gm-CSf, GMCSF, MGI-IGM","MGI:1339752","colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Ashley R Dunn","Csf2<tm1Ard>","MGI:1930997","11",{"$nulls":28},"Perturbed macrophage biology, disrupted haematopoiesis and metabolism","Normal","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[6903,"ERT2/Pten/Gp130F; A33(CreERT2)/Pten loxP/Gp130y757F (ME-276)","STOCK Gpa33<tm1(cre)Ern> Il6st<tm1Ern> Pten<tm2Mak>/LudApb",null,"Dominant","interleukin 6 signal transducer","Il6st",null,"5133400A03Rik, CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":61},"009/09"]
[5436,"Funky","C.Cg-Ndufs4<fky>/DrthApb","C.Cg-Ndufs4<fky>/Drth","Recessive","NADH dehydrogenase (ubiquinone) Fe-S protein 4","Ndufs4","Reduced","C1-18k","MGI:1343135","funky","Ndufs4<fky>","MGI:4942335","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous mice initially present with fur loss around postnatal day 14, which regrows in the next hair cycle. They show reduced growth and several behavioural abnormalities that appear from postnatal week five, such as tilting of the head, walking in circles and twisting of the body when suspended by the tail. Due to progressively wobbly gait and general deterioration in physical condition, all homozygous mice have to be euthanased around postnatal week eight in compliance with ethical guidelines.","Animals show reduced growth and several behavioural abnormalities that appear from postnatal week five to six, such as a ruffled appearance, tilting of the head, walking in circles and twisting of the body when suspended by the tail. Due to progressively wobbly gait and general deterioration in physical condition, all homozygous mice have to be euthanased around postnatal week nine in compliance with ethical guidelines.","BALB/c","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good","11",null,"het X het","No","2011-02-15","Cryopreserved sperm",80,0,null,null,"false",null,"David","Thorburn","Murdoch Childrens Research Institute","david.thorburn@mcri.edu.au","10th Floor, Royal Children","Parkville ","VIC","Ann","Frazier","ann.frazier@mcri.edu.au","A662","126b/2007 PC1 NLRD","Yes"]
[6794,"S164","SJL/J-tg(TCR1640)/Ausb",null,"Recessive",{"$nulls":39},"SJL/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-01-19",null,0,0,"ABR - Moss Vale","2625","true",null,"David","Brown","St Vincent's Centre for Applied Medical Research","a.irvine@amr.org.au",{"$nulls":6},"N/A","N/A","No"]
[6847,"Slit2","STOCK-Slit2<tm1Matl>/MmmhUqbr",null,"Dominant","slit homolog 2 (Drosophila) ","Slit2","Unknown","Drad-1, E030015M03Rik, E130320P19Rik, Slil3","MGI:1315205","slit homolog 2 (Drosophila); targeted mutation 1, Marc Tessier-Lavigne","Slit2<tm1Matl>","MGI:2179460","5",{"$nulls":28},"Partial perinatal lethality: almost all homozygotes die at birthAbnormal embryonic tissue morphology: * at E11.5 multiple ureteric buds (3 or more buds in 14/16 mutants, and 2 in 2/16) emerge from the nephric duct rather than a single bud as in wild-type mice  * some of these buds project medially rather than dorsallyAbnormal kidney morphology: at E18.5 the region where new nephrons are being generated is not restricted to the periphery as in wild-type mice but extends into the interior of the kidney in homozygotes.Abnormal kidney development: * many of the multiple ureteric buds have developed to give rise to 2 or more adjacent kidneys * fusion of these adjacent kidneys may cause the interior nephrogenesis seen at E18.5.Abnormal ureter morphology: * multiple ureters arising from a single kidney are seen in all homozygous mutants * all of the ureters remain connected to the nephric duct rather than undergoing remodeling to connect to the bladder.Hydroureter: at E18.5 the collecting ducts and ureters are grossly dilated.",null,"CD-1","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown","More than 10.","Unknown","Heterozygous x wild type","No","2012-03-13",null,0,0,"UQ",null,"true",null,"Linda","Richards","Queensland Brain Institute","richards@uq.edu.au",{"$nulls":3},"John","Baisden","j.baisden@uq.edu.au","QBI/165/09/BREDD/NHMRC/ARC(NF)","NLRD 21618/2007","No"]
[6782,"MC4R^","C57BL/6-Mc4r<m1Btlr>/MmcdAusb",null,"Semi-dominant","melanocortin 4 receptor ","Mc4r",null,"Fatboy","MGI:99457 ","melanocortin 4 receptor; mutation 1, Bruce Beutler ","Mc4rm1Btlr","MGI:3723065","18","ENSMUSG00000047259","ENSMUST00000057942","Mc4r-201 ",{"$nulls":25},"Homozygous mice are very obese at 6 weeks of age. Pre weaning mortality 13.9%, hyperphagia, fasting hyperinsulinemia. ","Hets larger than wildtype mice","C57BL/6J ","Yes","Yes","Yes","Yes","Unknown","Yes","No","Unknown",null,null,"het x het or het(F) x homo(M) breeding","No","2012-01-13",null,0,0,"ABR - Moss Vale","777","true",null,"Samuel","Breit","St Vincent's Centre for Applied Medical Research","a.irvine@amr.org.au",{"$nulls":6},"N/A","N/A","No"]
[5186,null,"ENU18WT:005b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm",90,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramanium","anusha.subramaniam@anu.edu.au","J.APF.13.08","N/A","No"]
[5190,null,"ENU18WT:027b",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-08-02","Cryopreserved sperm",47,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","J.APF.13.08","N/A","No"]
[7217,"Sppl2a KO1","C57BL/6N-A<tm1Brd> Sppl2a<tm1a(EUCOMM)Hmgu>/1MarpAnu",null,"Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802","signal peptide peptidase like 2A; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Sppl2a<tm1a(EUCOMM)Hmgu>","MGI:4887673","2",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2012-11-19","Cryopreserved sperm",29,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7221,"G11-68","Gas11-68",null,"Recessive","Unknown","Unknown",{"$nulls":6},"6",{"$nulls":28},"Patterning defects.The homozygous mutant embryos die before 8.5 dpc.","Normal","C3H/HeH","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good","Three generation on C3H/HeH backround followed by  two genertion on C47BL/6.",null,null,"No","2012-11-20","Cryopreserved sperm",79,0,"ANU",null,"true",null,"Ruth","Arkell","The Australian National University","Ruth.Arkell@anu.edu.au",{"$nulls":3},"Alaa","Alzahrani","Alaa.Alzahrani@anu.edu.au","A2011/63",null,"No"]
[5377,"hPI Triple 427","C57BL/6-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427 Tg(TcraINS1,TcrbINS1)/Apb",null,"Dominant","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No","human leukocyte antigen class II",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-12-22","Cryopreserved sperm",50,0,"St V",null,"false",null,"Stuart","Mannering","St Vincent's Institute","smannering@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells"]
[7229,"APN310","C57Bl/6NTac-Ptcd1<tm1(KOMP)Vlcg>/Marp",null,"Recessive","pentatricopeptide repeat domain 1","Ptcd1","Unknown","1110069M14Rik","MGI:1919049","pentatricopeptide repeat domain 1; targeted mutation 1, Velocigene/Marp","Ptcd<1tm1(KOMP)Vlcg/Marp>","MGI:4951221","5",{"$nulls":28},"Unknown","Normal","C57Bl6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-11-22","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[7231,"Sftpc+/+ 129","129/Sv-Sftpc<WT>/MarpApb",null,"Recessive","surfactant associated protein C","Sftpc","Nil","pro-SpC, Sftp2, Sftp-2, SP-C","MGI:109517",{"$nulls":3},"14",{"$nulls":28},"Normal.Wildtype strain developed from Het x het mating of knockout mice.Used as control for experiments.","Normal","129/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">20",null,null,"No","2012-11-27","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Rebecca","Lim","MIMR-PHI Institute of Medical Research","rebecca.lim@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[7227,"APN281","C57Bl/6N-A<tm1Brd> Oas2<tm1a(EUCOMM)Hmgu>/Marp",null,"Recessive","2'-5' oligoadenylate synthetase 2","Oas2","Unknown","2'-5' oligoadenylate synthetase-like 11, Oasl11","MGI:2180852","2'-5' oligoadenylate synthetase 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Oas2<tm1a(EUCOMM)Hmgu>/Marp","MGI:4434541","5",{"$nulls":28},"Unknown","Normal","C57Bl6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2012-11-22","Cryopreserved sperm",40,0,"ABR - Moss Vale",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","deborah.bianco@monash.edu",{"$nulls":3},"Deborah","Bianco","deborah.bianco@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[7282,"Cathepsin-S Knockout","B6NCrl;129-Ctss<tm1Hap>/AnuApb",null,"Recessive","cathepsin S","Ctss","Nil","Cat S","MGI:107341","cathepsin S; targeted mutation 1, Harold A Chapman","Ctss<tm1Hap>","MGI:2182133","3",{"$nulls":15},"Yes",{"$nulls":12},"Defective CD4 T cell response and humoral responses, but no overt immunodeficiency.  Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-02-27","Cryopreserved sperm",20,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","Anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7387,"KRasG12D","B6.129-Kras<tm4Tyj>/JAnuApb",null,"Dominant","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","Kras","Normal","Ki-ras, K-ras, Kras2, Kras-2","MGI:96680","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks","Kras<tm4Tyj>","MGI:2429948","6",{"$nulls":28},"Normal until mice crossed with Cre expressing strain.Expression of adenovirus controlled Cre recombinase results in lung tun our development.Treatment with adenoviral Cre injection results in ovarian endometriosis like lesions.Abnormal peritoneum morphology: * 47% of mutants develop peritoneal endometriosis following ovarian intrabursal injection of an adenovirus expressing Cre * however, mice injected with adenovirus expressing Cre directly into the peritoneum do not develop peritoneal endometriosis.",null,"C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-07-30","Cryopreserved sperm",60,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Ayla","Lorenzo","ayla.lorenzo@anu.edu.au","N/A","N/A","No"]
[7240,"ADAR1 E861A","C57BL/6-Adar<tm1.1Xen>/SviApb",null,"Dominant","adenosine deaminase, RNA-specific","Adar ","Unknown","ADAR1, mZaADAR","MGI:1889575 ","adenosine deaminase, RNA-specific; targeted mutation 2184, TaconicArtemis","Adar1<tm1.1Xen>","MGI:5805648","3",{"$nulls":28},"Homozygous lethal at ~E12.5","heterozygous animals are normal and fertile with no apparent abnormalities","C57BL/6","No","Yes","Yes","No","Yes","Yes","No","Good","on pure C57BL/6 - was derived on C57 ES line",null,"ki/+ crossed to ki/+","No","2012-12-03","Cryopreserved sperm",36,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC032/11","IBC168","No"]
[7445,"ENU29:G1","ANU:ENU29:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2013-09-24","Cryopreserved sperm",1222,38,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anna ","Palkova","anna.palkova@anu.edu.au","A2011/41",null,"No"]
[7554,"ENU25:022:CASC5:B6","C57BL/6NCrlAnu-Casc5<m1Anu>/AnuApb","C57BL/6NCrlAnu-Casc5<m1Anu>/AnuApb","Recessive","cancer susceptibility candidate 5","Casc5","Unknown","2310043D08Rik, 5730505K17Rik","MGI:1923714","cancer susceptibility candidate 5; mutation 1, The Australian National University","Casc5<m1Anu>","MGI:5563500","2","ENSMUSG00000027326","ENSMUST00000028802","Casc5-004","2645","2661","T to A","ENSMUSE00000642270","7","882","Isoleucine to Lysine",{"$nulls":4},"TCTACCAGCAAAAGGCAGCCAGCTAACAATATTAGAGGAAGGGTCTAATAGCGGGCTTGGA",{"$nulls":13},"Possible embryonic lethal.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-12-19","Cryopreserved sperm",50,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[7464,"ENU30:G1","ANU:ENU30:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2013-10-29","Cryopreserved sperm",1361,40,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[7607,"ENU19:Mcm5","C57BL/6JAnu-Mcm5<m1Anu>/AnuApb","C57BL/6JAnu-Mcm5<m1Anu>/AnuApb","Recessive","minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)","Mcm5","Unknown","Cdc46, mCD46, Mcmd5","MGI:103197","minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae); mutation 1, The Australian National University","Mcm5<m1Anu>","MGI:5563450","8","ENSMUSG00000005410","ENSMUST00000164309","Mcm5-202",{"$nulls":7},"77648844","15",null,null,"GGATGCTGCTTTGTCTGGCAATCTGTCGGGTGAGTAAGCGCTGGACTGTGGTCTTGGACG",{"$nulls":13},"Embryonic Lethal.No pups carrying homozygous genotype are born",null,"C57BL/6JAnu","No","No","Yes","No","No","Yes","No","Unknown",null,"G3","Het x Het","No","2014-02-27","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[4977,"ENU11B6:024b ; Servalan","C57BL/6JAnu-Ebf1<serv>/3AnuApb","C57BL/6JAnu-Ebf1<serv>/3AnuApb","Recessive","early B-cell factor 1","Ebf1","Unknown","O/E-1, Olf-1, Olf1","MGI:95275","early B-cell factor 1; Servalan","Ebf1<Serv>","MGI:5007783","11","ENSMUSG00000057098","ENSMUST00000081265","Ebf1-001",{"$nulls":12},"No",{"$nulls":12},"Small decrease in peripheral blood B cell numbers.Slight decrease in spleen B cell numbers","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-22","Cryopreserved sperm",18,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Carla","Roots","carla.roots@anu.edu.au","J.APF.13.08","N/A","No"]
[7608,"BALB/b","BALB/c-H2<b>/AnuApb",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","Balb/c is usually H2<d>.  The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-02-28","Cryopreserved sperm",50,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[5608,"ARC(S)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5575,"Setx; Setx on C57/BL6Jx129Sv background","B6;129-Setx<tm1Mla>/QimrApb","15","Recessive","senataxin","Setx","Nil","AOA2; Als4; Sen1; SCAR1; AW060766; mKIAA0625; A130090N03; A930037J23Rik.","MGI:2443480 ",{"$nulls":3},"2",{"$nulls":28},"Black or bown coat, Normal size, normal body, weight, normal life span. Male sterility","Normal","C57BL/6J x 129Sv","Yes","No","Yes","Yes","No","Yes","Yes","Good",null,"30","Hetrezygotes x Heterozygotes","No","2011-09-01","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Martin","Lavin","Queensland Institute of Medical Research","martin.lavin@qimr.edu.au",{"$nulls":3},"John","Luff","johnLu@qimr.edu.au","A0207-612M","NLRD 386/2011","Yes"]
[5338,"B6.tx","C57BL/6-Atp7b<tx>/Apb",null,"Recessive","ATPase, Cu++ transporting, beta polypeptide","Atp7b","Normal","Atp7a, Wilson protein, WND","MGI:103297","ATPase, Cu++ transporting, beta polypeptide; toxic milk","Atp7b<tx>","MGI:1856220","8",{"$nulls":15},"Yes",{"$nulls":12},"Postnatal lethality:  * mice die at about 14 days of age. * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Reduced female fertility: older female mice exhibit decreased fertility compared to wild-type mice.Abnormal mineral level: mice exhibit an increase in zinc the brain, liver and muscle.Abnormal copper level: mice exhibit an increase copper accumulation in the kidney, spleen, brain, muscle, serum and red blood cells.Decreased circulating copper level.Decreased liver copper level: in postnatal mice.Increased liver copper level: in adult mice.Tremors:  * mice exhibit tremors. * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Ataxia: * mice exhibit difficulty walking, listing from side to side, overbalancing, falling over and exerting great effort in righting themselves. * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Decreased body weight: * mice reach their maximal weight at day 9 (70% of wild-type) and exhibit weight loss until their death. * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Postnatal growth retardation: * apparent within a day or two after birth * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Abnormal muscle physiology: * mice exhibit hyperextension of hindlimbs and hyperflexion of wrists. * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Diluted coat colour: * mice exhibit pale coat color * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age).Hypopigmentation: * pigment contained within melanocytes is lighter than normalseverity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Curly vibrissae: * mice exhibit curly whiskers * severity of defects depends on genetic background (less severe on a mixes C57BL/6 background) and maternal age (decreasing severity with increasing maternal age). * however, fostering with wild-type dams reverses many defects depending on the age of onset of fostering.Maternal effect: pups suckled by homozygous mothers are deficient in copper concentration in their stomach contents and liver, and supplementing the drinking water of the homozygous mother with copper does not increase the copper content of the milk but rather increases the copper accumulation in the mammary gland.Endocrine/exocrine gland phenotype: * mammary glands are structurally normal by histology.Defects are less severe on C57BL/6 background compared to DL background.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2010-12-11","Cryopreserved sperm",70,0,null,null,"false",null,"Julian","Mercer","Deakin University","julian.mercer@deakin.edu.au",{"$nulls":3},"Roxana","Llanos","roxana.llanos@deakin.edu.au","N/A","N/A","No"]
[7568,"Mt3KO:ANU","B6.129-Mt3<tm1Rpa>/Apb",null,"Recessive","metallothionein 3","Mt3","Nil","MT-3","MGI:97173","metallothionein 3; targeted mutation 1, Richard D Palmiter","Mt3<tm1Rpa>","MGI:2389488","8",{"$nulls":28},"Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury.","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Excellent",{"$nulls":3},"No","2014-01-17","Cryopreserved sperm",50,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41","10.02","No"]
[8713,"Kynu null","C57BL/6N-Kynu<em1Dunw>/DunwApb",null,"Recessive","kynureninase","Kynu","Nil","4432411A05Rik, L-kynurenine hydrolase","MGI:1918039","kynureninase; endonuclease-mediated mutation 1, Sally L Dunwoodi","Kynu<em1Dunw>","MGI:6285803","2",{"$nulls":28},"Normal","Normal","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-05-13","Cryopreserved sperm",50,0,null,null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":8},"No"]
[5345,"SS-11 ; Vegfd 2.2.36","C57BL/6-Figf<tm1Mach>/Apb",null,"X-linked","c-fos induced growth factor","Figf","Nil","VEGF-D, Vegfd","MGI:108037","c-fos induced growth factor; targeted mutation 1, Marc G Achen","Figf<tm1Mach>","MGI:3576785","X",{"$nulls":28},"No abnormal phenotype detected: homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.Mice have reduced numbers of lymphatic vessels in lungs.","Normal","129S1/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","0",null,null,"No","2010-12-15","Cryopreserved sperm",100,0,null,null,"false",null,"Marc","Achen","Peter MacCallum Cancer Centre","marc.achen@petermac.org",{"$nulls":6},"010/09","040/2001 & 304","No"]
[7245,null,"NOD.B6 Idd9/11",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11","Idd11<C57BL/6>","MGI:3036811","4",{"$nulls":61},"N/A"]
[7251,"ENU22:4930473A06Rik","C57BL/6NCrlAnu-Ccdc171<m1Anu>/AnuApb",null,"Dominant","coiled-coil domain containing 171","Ccdc171","Unknown","4930418J05Rik, 4930473A06Rik, A330015D16Rik","MGI:1922152","coiled-coil domain containing 171; mutation 1, The Australian National University","Ccdc171<m1Anu>","MGI:5570360","4","ENSMUSG00000052407","ENSMUST00000053414","Ccdc171-001","2586","2913","T to A","ENSMUSE00001208951","18","862","Cysteine to STOP",{"$nulls":4},"CCAAAACATCAGAGGGAACAGTTACGCTGTTTACAGGCACTCGCGTGGCTCACCAGTTCTG",{"$nulls":13},"Reduced peripheral B cells, high IgM and low IgD expression","Reduced peripheral B cells, increased population of IgM very high immature B cells","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Yes","Yes","No","Good",null,"3",null,"No","2012-12-14","Cryopreserved sperm",32,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","Lisa.Miosge@anu.edu.au","A2011/41",null,"No"]
[5357,"B6.427","C57BL/6-Tg(HLA DR4-DQ8)427/Apb",null,"Dominant",{"$nulls":25},"human leukocyte antigen class II",{"$nulls":11},"HLA DR4 and DQ3 expression was evident on B cell but not T cells, dendritic cells and a proportion of macrophages.DR4-DQ3 mice develop protective immunity following infectious challenge with S. typhimurium.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"31",null,"No","2010-12-20","Cryopreserved sperm",45,0,null,null,"false",null,"James","McCluskey","The University of Melbourne","jamesm1@unimelb.edu.au",{"$nulls":3},"Catherine","Keech","clkeech@unimelb.edu.au","N/A","N/A","No"]
[7614,"ENU24:029:Agtr2","C57BL/6NCrlAnu-Agtr2<m1Anu>/AnuApb","C57BL/6NCrlAnu-Agtr2<m1Anu>/AnuApb","Recessive","angiotensin II receptor, type 2","Agtr2","Unknown","AT2 receptor","MGI:87966","angiotensin II receptor, type 2; mutation 1, The Australian National University","Agtr2<m1Anu>","MGI:5648447","X","ENSMUSG00000068122","ENSMUST00000089188","Agtr2-001","353","599","A to T","ENSMUSE00000556750","3","118","Lysine to STOP",{"$nulls":4},"TGATTGGCTTTTTGGACCTGTGATGTGCAAAGTGTTTGGTTCTTTTCTGACTCTGAACATG",{"$nulls":13},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Yes","Yes","No","Excellent",null,"G4",null,"No","2014-03-04","Cryopreserved sperm",36,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[4135,null,"NOD.B6-Prkdc<scid> B2m<tm1Jae> Tg(B2m<b>)1Rms/MarpApb",null,"Semi-dominant","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":58},"Robyn","Slattery","Robyn.Slattery@med.monash.edu.au","N/A","N/A"]
[2393,"BCMA KO; BCMA 49.29 KO:G1","B6.129-Tnfrsf17<tm1Msc>/AnuApb",null,"Recessive","tumor necrosis factor receptor superfamily, member 17","Tnfrsf17","Nil","BCM, Tnfrsf13, Tnfrsf13a","MGI:1343050","targeted mutation 1, Martin L Scott","Tnfrsf17<tm1Msc>","MGI:2387427","16",{"$nulls":15},"No",{"$nulls":12},"Mice homozygous for targeted null mutations in this gene are viable and fertile with no apparent defects in immune system development or function.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-20","Cryopreserved sperm",80,0,"ANU",null,"true",null,"Frederic","Sierro","Garvan Institute","f.sierro@garvan.org.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells"]
[5677,"CD1d -/-",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5682,"Cep55-MMTV-cCe",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5683,"CFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5691,"Clone 741-304 B",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5705,"Crim1 FloxC57 TRANSGELIN-Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5710,"CX3 CR1",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5712,"Cx3cr1; Cx3cr1-GFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5728,"Deb Black NesCreERT2",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5735,"Dicer,Flox,Math1,CRE",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5745,"E2F8-/- (295/09)",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5746,"E7TCR269",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5767,"EPHA4Loxp",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5770,"ExtraToes",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5781,"Fgf8FloxC57/Rosa26/Emx1Cre",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5786,"FgFr2 flox flox",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5792,"FVBN",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5799,"Gbx2 -mCherry",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
[5805,"Gfap-EGFP",{"$nulls":43},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,null,null,"true",null,"Unknown",{"$nulls":9},"N/A","N/A","No"]
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[7399,"Alk5loxp","B6.129P2-Tgfbr1<tm1.1Karl>/UscAusb",null,"Recessive","transforming growth factor, beta receptor I","Tgfbr1","Normal","Alk-5, ALK5, TbetaRI, TbetaR-I","MGI:98728","transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson","Tgfbr1<tm1.1Karl>","MGI:2680164","4",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-08-16",null,0,0,"Moss Vale","3279","true",null,"Sam","Breit","Garvan Institute","sam.breit@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[7617,"Helios floxed","B6.Cg-Ikzf2<tm1.1Etms> Tg(CD4-Cre)/Anu",null,"Recessive","IKAROS family zinc finger 2","Ikzf2",null,"A730095J18Rik, Helios, Zfpn1a2","MGI:1342541","IKAROS family zinc finger 2; targeted mutation 1.1, Ethan M Shevach","Ikzf2<tm1.1Etms>","MGI:4456473","1",{"$nulls":16},"transgene insertion 1, Christopher B Wilson","CD4",{"$nulls":10},"Abnormal regulatory T cell physiology:• regulatory T cells fail to respond to TCR stimulation or IL2 unlike wild-type cells• however, regulatory T cells respond normally to anti-CD3 and IL2 and are as suppressive as wild-type regulatory T cells",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-03-07","Cryopreserved sperm",9,0,"ANU",null,"true",null,"Ian","Parish","The Australian National University","ian.parish@anu.edu.au",{"$nulls":6},"A2011/46 ","11.16","No"]
[7412,"ENU27:007:ETS1","C57BL/6NCrlAnu-Ets1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Ets1<m1Anu>/AnuApb","Recessive","E26 avian leukemia oncogene 1, 5' domain","Ets1","Unknown","Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1","MGI:95455","E26 avian leukemia oncogene 1, 5' domain; mutation 1, The Australian National University","Ets1<m1Anu>","MGI:5563474","9","ENSMUSG00000032035","ENSMUST00000034534","Ets1-001","1001","1363","C to T","ENSMUSE00000537123","7","334","Proline to Leucine",{"$nulls":4},"TGCCCTGGCTGGCTACACAGGAAGTGGGCCGATCCAGCTGTGGCAGTTTCTTCTGGAATTA",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, C4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-08-23","Cryopreserved sperm",29,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[7416,"ENU26:029:WDR89:B6","C57BL/6NCrlAnu-Wdr89<m1Anu>/AnuApb","C57BL/6NCrlAnu-Wdr89<m1Anu>/AnuApb","Recessive","WD repeat domain 89","Wdr89","Unknown","2600001A11Rik","MGI:1919588","WD repeat domain 89; mutation 1, The Australian National University","Wdr89<m1Anu>","MGI:5563398","12","ENSMUSG00000045690","ENSMUST00000062370","Wdr89-201","428","524","A to T","ENSMUSE00000368540","2","143","Leucine to STOP",{"$nulls":4},"TGCAGAGAAAGTTGACGAGGATGCATTGTTGGTATTTTGGGATGCAAGGTTCACATCTCAG",{"$nulls":13},"Normal blood lymphocyte populations phenotype as measured by flow cytometry screen.Parameters tested-Expression of following proteins: B220, CD3, C4, CD44, KLRG1, NK1.1, IgM, IgD.",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",null,"G3",null,"No","2013-08-23","Cryopreserved sperm",15,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[7618,"SVS7 -/-","C57BL/6-Pate4<tm1>",null,"Semi-dominant","Prostate and Testes Expressed 4 (PATE4)","Pate4","Nil","9530004K16Rik, Pate-B, Svs7, SVS VII","MGI:1930790",{"$nulls":3},"9",{"$nulls":28},"Display osteopenia - reduced bone volume in the femur and tibia at 3 months as assessed by microcomputed tomography.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-03-11","Cryopreserved sperm",50,0,null,null,"false",null,"Jiake","Xu","The University of Western Australia","jiake.xu@uwa.edu.au",{"$nulls":6},"RA3/300/091","RA/5/1/407","No"]
[7425,null,"B6/Mrit-MRI95318","B6/Mrit-MRI95318","Dominant","unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Heterozygous mice display an harmonious and transient growth retardation","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2013-08-27","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[7421,null,"SJL/Mrit-Tfrc<MRI97707>Apb",null,"Dominant","transferrin receptor","Tfrc","Reduced","2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr","MGI:98822",{"$nulls":3},"16",{"$nulls":28},"Prenatal mortality (E15) with severe anaemia and fragmented red blood cells","Heterozygous mice display a microcytic anaemia with decrease osmotic fragility.","SJL/J","No","No","Yes","No","No","Yes","No","Good","4",null,null,"No","2013-08-27","Cryopreserved sperm",50,0,null,null,"false",null,"Gaetan","Burgio","Macquarie University","gaetan.burgio@mq.edu.au",{"$nulls":6},"2012/019",null,"No"]
[6589,"BALB/c-2","Nod/Lt.C-Idd5<BALB/c> Idd1<BALB/c> Ubash3a<rs48725557-C>/Arc",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 5","Idd5",null,"Idd-5","MGI:96407","insulin dependent diabetes susceptibility 5; BALB/c","Idd5<BALB/c>",null,"1","As per background strain.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","3",null,null,"No","2011-09-29","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[7692,"Rag2-fl","C57BL/6-Rag2<tm1Cgn>/JAusb",null,"Recessive","recombination activating gene 2","Rag2","Normal","Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, University of Cologne","Rag2<tm1Cgn>","MGI:2654906","2",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2014-05-22",null,0,0,"ABR - Moss Vale","3776","true",null,"John","Mattick","Garvan Institute","director@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[5058,"Cauli ; ENU12B6:C3H:003","B6;C3H-Ift140<cauli>/AnuApb","B6;C3H-Ift140<cauli>/AnuApb","Recessive","intraflagellar transport 140 homolog (Chlamydomonas)","Ift140",null,"mKIAA0590, Tce5, Wdtc2 ","MGI:2146906 ","cauli","Ift140<cauli>","MGI:4458412","17","ENSMUSG00000024169","ENSMUST00000024983","Ift140-001","2564","3109","T to A","ENSMUSE00000551541","19","855","Isoleucine to Lysine",{"$nulls":4},"ACTGGAAGCCAGAGTGGCCATGCTGGCCATACAGCTGGGCATGCTGGAGGAGGCAGAACAA","Yes",{"$nulls":12},"Phenotype found in 13.5 dpc embryo. Phenotype is exencephaly, hind limb polydactyly, forelimbs have a mixture of polydactyly and oligodactyly and midfacial cleft.","Normal","C57BL/6 x C3H","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2007-05-02","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Tiong","Tan","Murdoch Childrens Research Institute","tiong.tan@mcri.edu.au",{"$nulls":3},"Anna ","Chappell","anna.chappell@anu.edu.au","J.APF.13.08","N/A","No"]
[7431,"APN 371","C57BL/6N-A<tm1Brd> Katna1<tm1a(KOMP)Wtsi>MarpApb",null,"Recessive","katanin p60 (ATPase-containing) subunit A1","Katna1 ",null,null,"MGI:1344353 ","katanin p60 (ATPase-containing) subunit A1; targeted mutation 1a, Wellcome Trust Sanger Institute ","Katna1tm1a(KOMP)Wtsi","MGI:4458514","10",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-09-05","Cryopreserved sperm",30,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MARP/2012/105","PC1-N09/07","No"]
[7441,"ENU24:011:Ngf:B6","C57BL/6NCrlAnu-Ngf<m1Anu>/Apb",null,"Recessive","nerve growth factor","Ngf","Unknown",null,"MGI:97321","mutation 1, The Australian National University","Ngf<m1Anu>",null,"3","ENSMUSG00000027859","ENSMUST00000106925","Ngf-202","548","646","A to G","ENSMUSE00001274982","4","183","Histidine to Arginine",{"$nulls":4},"CCATGGTACAATCCCTTTCAACAGGACTCACCGGAGCAAGCGCTCATCCACCCACCCAGTC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-09-19",null,0,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","A2011/41",null,"No"]
[5386,"Fat Aussie","NOD.B10-Alms1<foz>/AnuApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Mice are hyperphagic leading to obesity and diabetes. Males are sterile. High fat feeding accelerates obesity and diabetes development, and leads to nonalcoholic steatohepatitis which progresses to liver fibrosis.Insulin resistance: female mice develop insulin resistance by 200 days of age.Increased eating behavior: mutants eat more than wild-type.Abnormal hepatocyte morphology: mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells.Enlarged liver: mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g).Increased liver weight: liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g).Liver fibrosis: mutant livers show pericellular and pericentral fibrosis.Hepatic steatosis: chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis.","Normal","NOD.B10","Yes","Yes","Yes","Yes","No","Yes","Yes","Excellent",">10",null,"heterozygote mating","No","2011-01-17","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Geoffrey","Farrell","The Australian National University","geoff.farrell@anu.edu.au","PO Box 11","Woden","ACT","Claire","Larter","claire.larter@anu.edu.au","F.MS.16.08","n/a","Yes"]
[7442,"ENU22:SCIN:B6","C57BL/6NCrlANu-Scin<m1Anu>/Apb",null,"Recessive","Scinderin","SCIN","Unknown","adseverin","MGI:1306794","scinderin; mutation 1, The Australian National University","Scin<m1Anu>","MGI:5570658","12","ENSMUSG00000002565","ENSMUST00000002640","Scin-001","1375","1495","G to T","ENSMUSE00000106304","10","459","Glutamine to Lysine",{"$nulls":4},"AACTGACCATGTCCGCGTTTCTGACTGTCCAGTTGGACCGGTCCCTTGGAGGGCAGGCTGT","Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2013-09-20","Cryopreserved sperm",66,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2011/41",null,"No"]
[7452,"Ghsr KO","C57BL/6-Ghsr<tm1Vlcg>/MarpApb",null,"Dominant","Growth hormone secretagogue receptor","Ghsr","Nil","C530020I22Rik","MGI:2441906",{"$nulls":3},"3",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"Yes","2013-10-08","Cryopreserved sperm",37,0,"Monash",null,"false",null,"Mark","Sleeman","Monash University","mark.sleeman@monash.edu",{"$nulls":3},"Mark","Sleeman","mark.sleeman@monash.edu","MARP/2012/007","PC1-N38/13","No"]
[7449,"IL-10R flox","STOCK Il10ra<tm1.1Jack>/WehiAnuApb",null,"Dominant","interleukin 10 receptor, alpha","Il10ra","Normal","CDw210, Il10r, mIL-10R","MGI:96538","interleukin 10 receptor, alpha; targeted mutation 1.1, Robert S Jack","Il10ra<tm1.1Jack>","MGI:4437317","9",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-10-02","Cryopreserved sperm",57,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Rebecca","Sweet","rebecca.sweet@anu.edu.au","A2012/05","13.10","No"]
[6643,"IPO5 FL/FL","C57BL/6-Ipo5<tm1>",null,"Dominant","importin 5","Ipo5","Normal","1110011C18Rik, 5730478E03Rik, IMB3, Kpnb3, Ranbp5","MGI:1917822",{"$nulls":3},"14",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"FL/FL x FL/FL","No","2011-11-07","Cryopreserved sperm",40,0,null,null,"true",null,"Kate","Loveland","Monash University","kate.loveland@monash.edu",{"$nulls":3},"Kate","Loveland","kate.loveland@monash.edu","SOBSB/B/2009/17","N/A","No"]
[7192,null,"ENU17WT049a",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Mice exhibit increased levels of ALT in the serum following administration of Acetaminophen.","NA","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","unknown","unknown","affected by affacted or unaffected by affected","No","2012-11-05","Cryopreserved sperm",40,0,"ANU",null,"true",null,"Edward","Bertram","The Australian National University","edward.betram@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","A2011/41",null,"No"]
[7458,"Ripply2null","ICR;B6CB(Cg)-Ripply2<tm1.1Ysa>/Rbrc",null,"Recessive","ripply2 homolog (zebrafish)","Ripply2","Nil","C030002E08Rik, LOC382089","MGI:2685968","targeted mutation 1, Yumiko Saga","Ripply2<tm1.1Ysa>","MGI:3758856","9",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"No",{"$nulls":12},"Null pups die perinatally with vertebal segmentation defects.","None","C57BL/6","No","No","Yes","No","No","Yes","No","Good","3","0","Rippl2null +/- (heterozygous) mated with C57BL/6","No","2013-10-22","Cryopreserved sperm",50,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","12/33","N21/2012","No"]
[7460,"Mesp2null","B6.Cg-Mesp2<tm13.1(cre/Esr1*)Ysa>/Rbrc",null,"Recessive","mesoderm posterior 2","Mesp2","Nil","bHLHc6","MGI:1096325","mesoderm posterior 2; targeted mutation 13, Yumiko Saga","Mesp2<tm13.1(cre/Esr1*)Ysa>","MGI:3715271","7",{"$nulls":15},"No",{"$nulls":12},"Null pups die perinatally with vertebal segmentation defects.","None","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10","0","Mesp2null +/- (heterozygous) mated with C57BL/6","No","2013-10-22","Cryopreserved sperm",50,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","12/33","N21/2012","No"]
[7461,"Hes7","B6.Cg-Hes7<tm1Kag>",null,"Recessive","hairy and enhancer of split 7 (Drosophila)","Hes7","Nil","bHLHb37","MGI:2135679","hairy and enhancer of split 7 (Drosophila); targeted mutation 1, Ryoichiro Kageyama","Hes7<tm1Kag>","MGI:2652222","11",{"$nulls":15},"No",{"$nulls":12},"Null pups die perinatally with vertebal segmentation defects.","Some heterozygous mice have tail kinks","C57BL/6","No","No","Yes","No","No","Yes","No","Good","10","0","Hes7 +/- (heterozygous) mated with C57BL/6","No","2013-10-22","Cryopreserved sperm",80,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.edu.au","12/33","N21/2012","No"]
[7463,"gp130Y757F/gp130Y757F x ApoE-/- x Stat3-/+","B6.Cg-Apoe<tm1Unc> Il6st<tm1Ern> Stat3<tm1Aki>/MarpApb",null,"Recessive","apolipoprotein E","Apoe","Nil",null,"MGI:88057","apolipoprotein E; targeted mutation 1, University of North Carolina","Apoe<tm1Unc>","MGI:1857129","7",{"$nulls":61},"N/A","N/A"]
[6653,"VavP-BCL2-69; C57BL/6-Tg(Vav-BCL2)1Jad/Wehi","ENU22Bcl2.006",null,"Dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":16},"transgene insertion 1, Jerry M Adams","mouse Vav promoter","High, haemopoietic cells",{"$nulls":10},"Abnormal lymphocyte cell number:* the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice.Increased B cell number: 5-fold higher in the spleen at 18 weeksIncreased T cell number:* mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice.Increased CD4-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Increased CD8-positive T cell number:* the increase in CD4+ T cells is greater than the increase in CD8+ T cells.Abnormal class switch recombination:* the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice.Abnormal somatic hypermutation frequency:* 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found.Enlarged spleen:Abnormal spleen germinal center morphology:* mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice.* at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice.* however, expansion of germinal centers is dependent on CD4 T cell help.Increased spleen germinal center number: at 18 weeks.Increased spleen germinal center size: at 18 weeks.Enlarged lymph nodes.Glomerulonephritis:* at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis.Increased tumor incidence:* 12% of mice develop plasma cell tumorsLymphoma: less than 10% of mice develop lymphoblastic lymphomas.B cell derived lymphoma:* less than 10% of mice develop large cell B lymphomasFollicular lymphoma:* at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma.Thymic lymphoma: in less than 10% of miceHistiocytic sarcoma: in less than 10% of mice.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-12-01","Cryopreserved sperm",10,0,null,null,"true",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":3},"Jennifer","Kofler","jennifer.kofler@anu.edu.au","N/A","N/A","No"]
[7469,"ENU12B6:020:G4","ANU:ENU12B6:020:G4",null,"Recessive","Unknown","Unknown",{"$nulls":6},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6JSfdAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Good",{"$nulls":3},"No","2013-10-31","Cryopreserved sperm",11,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Ayla","Lorenzo","ayla.lorenzo@anu.edu.au","A2011/41",null,"No"]
[7430,"APN 369","C57BL/6N-A<tm1Brd> Katna1<tm1a(KOMP)Wtsi>MarpApb",null,"Recessive","katanin p60 (ATPase-containing) subunit A1","Katna1 ",null,null,"MGI:1344353 ","katanin p60 (ATPase-containing) subunit A1; targeted mutation 1a, Wellcome Trust Sanger Institute ","Katna1tm1a(KOMP)Wtsi","MGI:4458514","10",{"$nulls":28},"Unknown","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2013-09-05","Cryopreserved sperm",20,0,"Monash",null,"true",null,"Australian Phenomics Network","ES Cell to Mouse Service","Monash University","leanne.cotton@monash.edu",{"$nulls":3},"Leanne","Cotton","leanne.cotton@monash.edu","MARP/2012/​105 ","PC1-N09/07​","No"]
[{"$nulls":30},"pRP-1345","proximal protamine 1 (Prm-1) promoter"]
[7484,"Clock Mel","CBA;B6-Clock<m1Jt>/Apb",null,"Semi-dominant","circadian locomotor output cycles kaput","Clock",null,"5330400M04Rik, bHLHe8, KAT13D, mKIAA0334","MGI:99698","circadian locomotor output cycles kaput; Clock","Clock<m1Jt>","MGI:1861634","5",{"$nulls":28},"The mutant animals displays an altered period of rhythmicity of wheel running activity in constant darkness (approx 27 hours), followed by arrythmicity after an extended period.","The heterozygote displays a slightly longer period of behavioural rhythmicity in constant darkness (approx 24.5 hours).","CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor","4","0","Maintain mutant and wild type as separate lines.","No","2013-11-14","Cryopreserved sperm",50,0,null,null,"false",null,"David","Kennaway","The University of Adelaide","david.kennaway@adelaide.edu.au",{"$nulls":3},"David","Kennaway","david.kennaway@adelaide.edu.au","M-2013-020",null,"No"]
[7127,"Ig1","FVB/N-Tg(Myl1-Igf1)1Nros/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Nadia Rosenthal","keletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 ","restricted to skeletal muscle and predominated in muscles enriched in fast fibers, such as the triceps or gastrocnemius.",{"$nulls":9},"Enlarged skeletal muscles especially in the forearms.",null,"FVB/N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-11-02",null,0,0,"ABR - Moss Vale","2194","true",null,"Edna","Hardeman","The University of New South Wales","e.hardeman@unsw.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8725,"ACAD10KO","C57BL/6-Acad10<em1>/Apb",null,"Recessive","Acyl-CoA Dehydrogenase Family Member 10","Acad10",null,"2410021P16Rik","MGI:1919235",{"$nulls":3},"5",{"$nulls":28},"Normal as far as initial experiments have shown","Normal as far as initial experiments have shown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-05","Cryopreserved sperm",50,0,null,null,"false",null,"Darren","Henstridge","Baker Heart Reseach Institute","darren.henstridge@baker.edu.au",{"$nulls":8},"No"]
[4524,null,"C57BL/6-Socs1<tm3wehi> Tg(Lck-cre)157Jxm/Apb",null,"Recessive","suppressor of cytokine signaling 1","socs1","Nil","Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1","MGI:1354910","targeted mutation 3, Walter and Eliza Hall Institute of Medical Research",null,"MGI:2656917","16",{"$nulls":15},"Yes","transgene insertion I57, Jamey Marth","lymphocyte protein tyrosine kinase (Lck)",{"$nulls":10},"Enhanced differentiation of thymocytes toward CD8+ T cells. Thymus hyperplasia.Enlarged lymph nodes",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm",95,0,"St V",null,"false",null,"Thomas","Kay","St Vincent's Institute","tkay@svi.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","43/08, BGMML#3","96, 73, #1228/2003","No"]
[7508,"rag1-cre","129S/SvEv-Rag1<tm1(cre)Thr>/WehiAusb","129S/SvEv-Rag1<tm1(cre)Thr>/WehiAusb","Dominant","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Terence H Rabbitts","Rag1<tm1(cre)Thr>","MGI:3584018","2",{"$nulls":28},"Abnormal lymphopoiesis:* fail to develop lymphocytes",null,"129/SvEv","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2013-11-19",null,0,0,"ABR - Moss Vale","3549","true",null,"John","Mattick","Garvan Institute","director@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[5469,"ENU12B6-C3/H:C3H:022","B6;C3H-Lig1<m1Anu>/AnuApb",null,"Recessive","ligase I, DNA, ATP-dependent","Lig1","Unknown","LigI, mLigI","MGI:101789","ligase I, DNA, ATP-dependent; mutation 1, The Australian National University","Lig1<m1Anu>","MGI:5510743","7","ENSMUSG00000056394","ENSMUST00000148471","Lig-001","1798","2054","A to T","ENSMUSE00000537286","19","600","Isoleucine to Phenylalanine",{"$nulls":4},"TACATGTTCTGGAAGGTGGAGAAGTGAAGATCTTCAGCAGGAACCAGGAAGACAACACAGG","Yes",{"$nulls":12},"Embryonic lethality. Embryos at E13.5 exhibit a pale, orange liver with failure of definitive erythropoiesis","Normal","C57BL/6J X C3H","No","No","Yes","No","No","Yes","Yes","Good",null,"3","het x het","No","2011-03-24","Cryopreserved sperm",45,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramaniamm","anusha.subramaniam@anu.edu.au","J.APF.13.08","N/A","No"]
[5462,"Str ; Stretcher","C.Cg-Ndrg1<str>/Arc","C.Cg-Ndrg1<str>/Arc","Recessive","N-myc downstream regulated gene 1","Ndrg1","Reduced","CAP43, CMT4D, DRG1, Ndr1, Ndrl, PROXY1, TDD5, Tdd5 ","1341799","N-myc downstream regulated gene 1; stretcher","Ndrg1<str>","MGI:5009138","15",{"$nulls":15},"Yes",{"$nulls":12},"Progressive peripheral neuropathy,tremor and the characteristic stretching of the hind-limbs and clasping when suspended, are seen from 5 weeks of age. The mice become progressively more severely affected until by 15 to 20 weeks they are very disabled, being not only weak but unable to control their hind legs which show severe flacid paralysis and highly abnormal positioning. The hind-legs muscles atrophy and the mice weigh less than their normal siblings. Clinically, the mice seem to stabilize after about 30 weeks of age and do not deteriorate further. ","Normal","BALB/c","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Excellent",{"$nulls":3},"No","2011-03-07",null,0,0,"ARC",null,"true",null,"Dora","Angelicheva","The Western Australian Institute for Medical Research","dora.angelicheva@uwa.edu.au","B Block, QEII MC","Nedlands","WA","Dora","Angelicheva","dora.angelicheva@uwa.edu.au","RA/3/300/40","N/A","No"]
[5467,"D6","B6.129/Sv-Ccbp2<tm1Gjg>/Apb",null,"Recessive","chemokine binding protein 2","Ccbp2","Nil","CCR10, CCR9, Cmkbr9, D6","MGI:1891697","chemokine binding protein 2; targeted mutation 1, Gerard J Graham","Ccbp2<tm1Gjg>","MGI:3623613","9",{"$nulls":15},"Yes",{"$nulls":12},"Increased inflammatory response: * subcutaneous injection of complete Freund's adjuvant (CFA) produces a granuloma-like lesion in homozygotes by 3 days post injection and 18 of 28 mutants develop grade 2 or higher lesions by 7 days post injection versus 2 of 28 wild-type mice * at the site of CFA injection increased necrosis, angiogenesis and leukocyte infiltration are seen * 3 days after CFA injection increase lymph node cellularity is seen in homozygotes compared to wild-type mice; however 7 days after injection wild-type contralateral lymph nodes display hyperplasia which is not seen in homozygotes.Dermatitis: * 24 hours after a single exposure of dorsal skin to 12-O-tetradecanoylphorbol-13-acetate (TPA) beta-chemokine levels remain elevated suggesting a defect in post-inflammatory clearance. * after 3 daily applications of TPA homozygotes develop a psoriasis-like skin lesion that is characterized by skin thickening, basal and suprabasal epidermal hyperproliferation, severe epidermal acanthosis, parakeratosis, hyperkeratosis, extensive growth of convoluted blood vessels, and a dense inflammatory cell infiltrate that includes high numbers of T cells * this TPA-induced inflammatory skin lesion persists for 6 to 10 days. * injection of TNF neutralizing antibodies, depletion of CD4+ and CD8+ T cells, or blockage of mast cell degranulation can prevent development of the TPA-induced psoriaform lesion.",null,"129/Sv x C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-03-22","Cryopreserved sperm",50,0,null,null,"false",null,"Cristina","Morganti-Kossmann","Monash University","cristina.morganti-kossmann@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[6553,"Fgf2Δ","B6.129P2-Fgf2<tm1Doe>/JAusb","B6.129P2-Fgf2<tm1Doe>/JAusb","Recessive","fibroblast growth factor 2","Fgf2","Nil","bFGF, Fgf-2, Fgfb","MGI:95516","fibroblast growth factor 2; targeted mutation 1, Thomas Doetschman","Fgf2<tm1Doe>","MGI:1857458","3",{"$nulls":28},"Abnormal vascular endothelial cell migration:*Following de-endothelialization and treatment with 17beta-Estradiol (E2), mice fail to re-endothelialize the site of injury unlike wild-type mice.*Endothelial precursor cell migration in response to E2 is disrupted.",null,"129/B6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","2280","true",null,"Bryce","Vissel","Garvan Institute","b.vissel@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[125,"Ceres ; MM4","C57BL/6SfdAnu-Tg(IghelM)Ccg/AnuApb","C57BL/6SfdAnu-Tg(IghelM)Ccg/AnuApb","Dominant",{"$nulls":25},"IgM-only anti-HEL transgene","Controlled by normal promoter","low, transgene H and L chains are cointergrated and driven under their normal elements",{"$nulls":11},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",37,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[5248,"Lyn STAT6 double knockout ; BALB.Lyn-/-STAT6-/-","C.Cg-Lyn<tm1Ard> Stat6<tm1Aki>/Apb",null,"Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn","Nil","Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; targeted mutation 1, Ashley R Dunn","Lyn<tm1Ard>","MGI:2157129","4",{"$nulls":15},"No",{"$nulls":12},"Mice develop exaggerated autoimmune disease compared with Lyn<-/-> mice.At a time-point where Lyn(-/-) mice showed only mild autoimmune disease, Lyn(-/-)STAT6(-/-) mice had maximal titres of IgG and IgA auto-Abs, impaired renal function, myeloid expansion and a highly activated T cell compartment. Remarkably, low level IgE auto-Abs but not IgG1 auto-Abs were a feature of some aged Lyn(-/-) STAT6(-/-) mice. Furthermore, aged Lyn(-/-)STAT6(-/-) mice showed dramatically increased levels of serum IgE but minimal IgG1, suggesting that class-switching to IgE can occur in the absence of an IgG1 intermediate.","Not defined","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-19","Cryopreserved sperm",50,0,"Ludwig",null,"false",null,"Cassandra","Thumwood","Ludwig Institute for Cancer Research, Melbourne","cassandra.thumwood@ludwig.edu.au","6th floor, Clinical Sciences Building, RMH, Royal Pde","Parkville","Victoria",{"$nulls":3},"031/08","040/2001 & 304","No"]
[2,"Unmodulated","C57BL/6JSfdAnu-Card11<unm>/AnuApb","C57BL/6JSfdAnu-Card11<unm>/AnuApb","Recessive","caspase recruitment domain family, member 11","Card11","Normal","CARMA1, BIMP3","MGI:1916978","unmodulated","Card11<unm>","MGI:3045963","5","ENSMUSG00000036526","ENSMUST00000085786","Card11-201","914","1235","T to A","ENSMUSE00000431473","7","305","Leucine to Glutamine",{"$nulls":4},"TGACTCAGACAAGGCCATCTTGGACATCCTGGAACATGACCGGAAGGAGGCGCTAGAGGAC","Yes",{"$nulls":12},"Diminished antibody formation upon T cell-independent type 2 and T cell-dependent immunization. Diminished B cell NFκB activation and proliferation to antigen receptor engagement, but normal proliferation to TLR4 stimulation. Failure to form normal IgMlow IgDhi follicular B cells, and failure to form peritoneal B1 B cells. Diminished T cell NFκB activation and proliferation to TCR+CD28 stimulation. Spontaneous dermatitis accompanied by dermal mastocytosis and hyper-IgE syndrome.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Poor",{"$nulls":3},"No","2005-11-25","Cryopreserved sperm",125,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Edward","Bertram","edward.bertram@anu.edu.au","J.APF.03.06","N/A","No"]
[8731,"Foxo1flox:Mb1CreERT2:B1-8:Tomato","B6.129-Cd79a<tm3(cre/ERT2)Reth> Foxo1<tm1Flv> Igh<tm1Mnz> Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>/AnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26 ","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Hongkui Zeng","Gt(ROSA)26Sor<tm9(CAG-tdTomato)Hze>","MGI:3809523","6"]
[90,"Willow","C57BL/6JSfdAnu-Jak3<wil>/AnuApb","C57BL/6JSfdAnu-Jak3<wil>/AnuApb","Recessive","Janus kinase 3","Jak3","Nil",null,"MGI:99928","willow","Jak3<wil>","MGI:3611885","8","ENSMUSG00000031805","ENSMUST00000051995","Jak3-001","2474","2771","G to T","ENSMUSE00000213233","18","825","Glycine to Valine",{"$nulls":4},"GAGACACCTTAAGTACATCTCTTTGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGC","No",{"$nulls":12},"Lymphopenia due to reduction of both Thy1.2⁺ and B220⁺ cellsReduced numbers of CD8⁺ cellsB cell block in transition from pro-pre B cells; Develop autoimmune inflammatory bowel disease associated with diarrhoea and prolapse. Homozygotes have reduced life span.? SCID phenotype.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",80,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT",{"$nulls":3},"J.APF.04.06","N/A","No"]
[7583,"ENU26:008:Klotho","C57BL/6NCrlAnu-Kl<m1Anu>/AnuApb","C57BL/6NCrlAnu-Kl<m1Anu>/AnuApb","Recessive","klotho","Kl",null,"alpha-kl","MGI:1101771","klotho; mutation 1, The Australian National University","Kl<m1Anu>","MGI:5563457","5","ENSMUSG00000058488","ENSMUST00000078856","Kl-201","984","1094","G to A","ENSMUSE00000191090","2","328","Tryptophan to STOP",{"$nulls":4},"CAGAAGTCTCTTGACTTTGTGCTAGGCTGGTTTGCCAAACCCATATTTATTGATGGCGACT",{"$nulls":13},"MacropathologyThe mouse displayed moderate dehydration and respiratory distress before euthanasia. Loops of small intestine were noted in the thoracic cavity upon opening of the thoracic cavity indicating the presence of a diaphragmatic hernia. The spleen was very small and the kidneys were bronze. No masses were noted on thepaws at necropsy.HistopathologyBrain, salivary gland, liver, oesophagus, ileum, caecum, colon, pancreas, lung – unremarkable.KidneyThe kidney displays severe mineralisation of the cortex. The areas of mineralisation are multifocal to coalescingand involve the tubular tissues as well as blood vessel walls. There is golden pigment present in the medullarytubules and collecting ducts.DuodenumThe lamina propria of the duodenum is effaced by the presence of large amounts of mineralisation.HeartThe heart displays severe multifocal mineralisation of the aorta and large blood vessels. In addition, there issevere mineralisation of tracheal cartilage rings and submucosa (still attached to heart).StomachThe glandular stomach displays severe dilatation of occasional gastric glands with necrotic cellular content aswell as fragments of calcium. In addition, severe mineralisation of all small blood vessels and the entiresubmucosa of the glandular stomach is apparent. Furthermore, moderate mineralisation of the smooth muscleof the tunica muscularis is also evident.SpleenThe spleen indicates an immunocompromised phenotype with a complete absence of periarteriolar lymphoidsheaths. Minimal haemopoiesis is evident in the red pulp.PawsThere is evidence of small, focal areas of mineralisation in the dermal tissue, connective tissue as well asadjacent to the bone. The bones display moderate medullary haemorrhage and lack of trabeculae which maybe related to excessive bone destruction resulting in hypercalcaemia.DiagnosisSevere, chronic, multifocal mineralisation of glandular stomach, kidney, aorta, duodenum, trachea,dermis/connective tissue of paws.Minimal splenic haemopoiesis and absence of periarteriolar lymphoid sheaths.",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-02-05","Cryopreserved sperm",29,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Lisa","Miosge","lisa.Miosge@anu.edu.au","N/A",null,"No"]
[2164,"Delficio ; ENU8F:005","B6;CBA-Clcn1<m1Anu>/AnuApb","B6;CBA-Clcn1<m1Anu>/AnuApb","Recessive","chloride channel 1","Clcn1","Unknown","Clc-1, Clc1, nmf310, NMF355, nmf355, SMCC1","MGI:88417","chloride channel 1; mutation 1, The Australian National University","Clcn1<m1Anu>","MGI:5563496","6","ENSMUSG00000029862","ENSMUST00000031894","Clcn1-201","99","181","C to A","ENSMUSE00000712505","1","32","Tyrosine to STOP",{"$nulls":4},"TACATGCCCTTTGAACATTGTACCAGCTACGGACTGCCCTCAGAGAATGGGGGCCTTCAGC","Yes",{"$nulls":12},"Progressive hindlimb weakness and ataxia with stiff gait. Develops sensory deficits and shows periods of increased muscular tone/tetany.",null,"C57BL/6JSfdAnu x CBA/H","Yes","No","Yes","Yes","No","Yes","No","Poor",null,"4","Het x Het","No","2007-10-15","Cryopreserved sperm",52,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A","N/A","No"]
[7552,"ENU25:011:Gdpd3:B6","C57BL/6NCrlAnu-Gdpd3<m1Anu>/AnuApb","C57BL/6NCrlAnu-Gdpd3<m1Anu>/AnuApb","Recessive","glycerophosphodiester phosphodiesterase domain containing 3","Gdpd3","Unknown","1110015E22Rik","MGI:1915866","glycerophosphodiester phosphodiesterase domain containing 3; mutation 1, The Australian National University","Gdpd3<m1Anu>","MGI:5563465","7","ENSMUSG00000030703","ENSMUST00000032944","Gdpd3-201","354","411","C to A","ENSMUSE00000202169","4","118","Tyrosine to STOP",{"$nulls":4},"CCCCTCTACAAGGAAGAGTTGGAAATTTACTTCTCACCAGGCCATTTTGCCCACGGGTCAG",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Poor",null,"G4",null,"No","2013-12-19","Cryopreserved sperm",56,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[2377,"Pengu, ENU8B6:075","C57BL/6Apb-Gdf5<png>/AnuApb","C57BL/6Apb-Gdf5<png>/AnuApb","Recessive","growth differentiation factor 5","Gdf5","Unknown","bp, brp, cartilage-derived morphogenetic protein-1, CDMP-1","MGI:95688","growth differentiation factor 5; pengu","Gdf5<png>","MGI:3847115","2","ENSMUSG00000038259","ENSMUST00000040162","Gdf5-001","2","314","T to C","ENSMUSE00000323175","1","1","Methionine to Threonine",{"$nulls":4},"ATGAGACTCCCCAAACTCCTCACTCTTTTGCTG","No",{"$nulls":12},"Limb deformity. Four shortened limbs with angular deformity, most pronounced in hindlimbs",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Good",{"$nulls":3},"No","2007-12-14","Cryopreserved sperm",53,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramanium","anusha.subramaniam@anu.edu.au","N/A","N/A","No"]
[157,"Lochy","C57BL/6JSfdAnu-Ptprc<loc>/AnuApb","C57BL/6JSfdAnu-Ptprc<loc>/AnuApb","Recessive","Protein tyrosine phosphatase, receptor type, C","Ptprc","Nil","B220, CD45, CD45R, Ly-5","MGI:97810","Lochy","Ptprc<loc>","MGI:3611894","1","ENSMUSG00000026395","ENSMUST00000027645","Ptprc-201",{"$nulls":7},"139980367","20",null,null,"TCCATAAATGACTGTTCTCTTTGTGTGTTTTGATCAGGGCTTCAAGGAACCCAGGAAATA","Yes",{"$nulls":12},"Decreased expression of CD45 on CD19⁺ B cellsloc/loc mice have normal numbers of B cellsCell intrinsic defectSlightly reduced levels of IgM⁺IgD⁻, IgM⁺IgD⁺ and IgD⁺CD21⁺ cellsReduced levels of B220loCD19⁺ cells but normal levels of B220⁺CD19⁺ in bone marrow3 fold decrease in DP thymocytes10 fold decrease in CD4 SP thymocytes5 fold decrease in CD8 SP thymocytesDP thymocytes had 2.5 fold increase in expression of CD4 and CD8, cell intrinsic Co-receptor expression on SP T cells was increased 1.5 foldDramatic decrease in CD8⁺CD44lo/med cellsTCRβ is up-regulated on DP thymocytes and down regulated on mature T cells. CD5 is down-regulated on DP thymocytes and up-regulated on peripheral T cells.Decrease in DP thymocytes is not cell intrinsicDecrease in SP thymocytes is cell intrinsicThe decrease of CD69 and CD5 on thymocytes in thymus was cell intrinsicNo CD45 protein visually detected by Western blottingInhibition of DN cells progressing to DPBlock preventing DP thymocytes maturing to SP T cells attributed to defective thymic selectionDecrease in peripheral T cellsReduction in naïve CD8+ T cells and shift to activated/memory CD8⁺ T cell phenotypeLack of TCRβhi and CD69⁺ cells in thymus-implies defect in TCR signalling for positive selection",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent",null,"7",null,"No","2006-03-06","Cryopreserved sperm",75,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.21.08","N/A","No"]
[7553,"ENU25:021:MAP4K1:B6","C57BL/6NCrlAnu-Map4k1<m1Anu>/AnuApb","C57BL/6NCrlAnu-Map4k1<m1Anu>/AnuApb","Recessive","mitogen-activated protein kinase kinase kinase kinase 1","Map4k1","Unknown","Hpk1","MGI:1346882","mitogen-activated protein kinase kinase kinase kinase 1; mutation 1, The Australian National University","Map4k1<m1Anu>","MGI:5563448","7","ENSMUSG00000037337","ENSMUST00000085835","Map4k1-201","400","502","A to G","ENSMUSE00000473624","6","134","Isoleucine to Leucine",{"$nulls":4},"GACTGGCCTACCTGCATTCAGAGAAGAAGATACATCGAGACATCAAGGGAGCCAACATCCT",{"$nulls":13},"Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, CD4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2013-12-19","Cryopreserved sperm",26,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[6,"Face","C57BL/6JSfdAnu-Stat1<fae>/AnuApb","C57BL/6JSfdAnu-Stat1<fae>/AnuApb","Recessive","signal transducer and activator of transcription 1","Stat1","Unknown","STAT-1","MGI:103063","face","Stat1<fae>","MGI:3611892","1","ENSMUSG00000026104","ENSMUST00000070968","Stat1-201","1978","2329","T to A","ENSMUSE00000630003","22","660","Methionine to Lysine",{"$nulls":4},"TCCCAGATATTATTCGCAACTACAAAGTCATGGCTGCCGAGAACATACCAGAGAATCCCCT","Yes",{"$nulls":12},"Diminished Th1 antibody formation upon immunization with heat-killed Bordetella pertussis bacilli. Increase proportion of CD44hi activated/memory T cells in a subset of animals and increased IgE.",null,"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"16","hom x hom","No","2005-11-28","Cryopreserved sperm",140,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Edward","Bertram","edward.bertram@anu.edu.au","J.APF.03.06","N/A","No"]
[123,"CD40L -/- TCR","B10JAnu.Cg-H2<k2> Cd40lg<tm1Flv> Tg(TcrHEL3A9)1Mmd/AnuApb","B10JAnu.Cg-H2<k2> Cd40lg<tm1Flv> Tg(TcrHEL3A9)1Mmd/AnuApb","Recessive","CD40 ligand","Cd40lg","Nil","CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5","MGI:88337","targeted mutation 1, Richard A Flavell","Cd40lg<tm1Flv>","MGI:2182733","X",{"$nulls":15},"No","transgene insertion 1, Mark M Davis","TCR",{"$nulls":10},"Homozygous mice display: - immune system, lymphoid development/B lymphocyte defects: -  B cells failed to undergo isotype switching -  failed to produce germinal centers in spleen in response to T-dependent antigens -  reduced serum immunoglobulin concentrations (IgG1, IgG2a, IgG2b, IgG3), at 12 weeks of age, but not at 6 weeks of age -  decreased IgM response to T-dependent antigens -  failed to produce antigen-specific IgG1 after immunization -  immune system, no defect detected: -  no alterations in B or T lymphocyte development -  T lymphocytes responded normally to mitogen stimulation -  B lymphocytes had normal responses to T-independent antigens",null,"C57BL/10J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"16",null,"No","2006-02-06","Cryopreserved sperm",150,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Chris","Goodnow","chris.goodnow@anu.edu.au","J.APF.02.05","N/A","No"]
[7621,"EGFL6 His Siamese","C57BL/6J-Tg(CMV-Egfl6/His)",null,"Dominant",{"$nulls":25},"EGF-like-domain, multiple 6","cytomegalovirus (CMV)",{"$nulls":10},"Generally the EGFL6 transgenic mice appear normal and have not displayed any adverse effects due to genetic modifications. ","Unknown","C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",{"$nulls":3},"No","2014-03-24","Cryopreserved sperm",50,0,null,null,"false",null,"Jennifer","Tickner","The University of Western Australia","jennifer.tickner@uwa.edu.au",{"$nulls":6},"RA/3/300/70","RA/5/1/417","No"]
[114,"Bcl-6 -/-","B6.129-Bcl6<tm1Sdt>/AnuApb","B6.129-Bcl6<tm1Sdt>/AnuApb","Recessive","B-cell leukemia/lymphoma 6","Bcl-6","Nil","Bcl5","MGI:107187","targeted mutation 1, Louis M Staudt","Bcl6<tm1Sdt>","MGI:2158439","16",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness. Mice frequently die before reaching maturation.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2006-02-06","Cryopreserved sperm",100,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Carola","Vinuesa","carola.vinuesa@anu.edu.au","J.APF.04.06","N/A","No"]
[166,"Cited<LacZ>","B6;129S4-Cited1<tm1Fmar>/Apb","B6;129S4-Cited1<tm1Fmar>/Apb","X-linked","Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1","Cited1","Nil","Msg1","MGI:108023","targeted mutation 1, Finian Martin","Cited1<tm1Fmar>","MGI:3623213","X",{"$nulls":15},"Yes",{"$nulls":12},"Results in retarded mammary ductal growth at puberty.","Females have no overt phenotype","C57BL/6","No","No","No","Yes","Yes","Yes","No","Good","3","11","Cited1<lacZ>/Y x +/Cited1<lacZ>","No","2006-04-15","Cryopreserved sperm",135,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.unsw.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.unsw.edu.au","03/28","465/2002","No"]
[165,"C2B6∆","B6.129P2-Cited2<tm1Jpmb>/Apb","B6.129P2-Cited2<tm1Jpmb>/Apb","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Nil","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1, Juan Pedro Martinez Barbera","Cited2<tm1Jpmb>","MGI:2176158","10",{"$nulls":15},"No",{"$nulls":12},"Embryos die during gestation (~E15.5). Heart, left-right axis, neural tube, adrenal gland and placental defects.","None","C57BL/6","No","No","No","No","No","Yes","No","Good","10","4","C2B6∆ +/- (heterozygous) mated with C57BL/6","No","2006-04-15","Cryopreserved sperm",130,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.unsw.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.unsw.edu.au","N/A","N/A","No"]
[5412,"NOD.IL-12SV x IL-12KO","NOD/Lt-IL12b<tm1Jm> Tg(IL12B)HJ15-3Gem/ArcApb",null,"Recessive","interleukin 12b","Il12b","Unknown","IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40","MGI:96540","interleukin 12b; targeted mutation 1, Jeanne Magram","Il12b<tm1Jm>","MGI:1857201","11",{"$nulls":15},"Yes","human interleukin 12b",null,"over-expression",{"$nulls":9},"Unknown.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2011-02-03","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[270,"gB -/-","C57BL/6-Gzmb<tm1Ley>/Apb",null,"Recessive","granzyme B","Gzmb","Nil","CCP-1/C11, CCP1, Ctla-1, Ctla1","MGI:109267","targeted mutation 1, Timothy J Ley","Gzmb<tm1Ley>","MGI:1857156","14",{"$nulls":15},"No",{"$nulls":12},"Homozygous mutant mice develop normally, with normal lymphopoiesis and hematopoiesis. However, CTLs from mutant mice are unable to induce rapid fragmentation of DNA and apoptosis in target cells; with long incubation, fragmentation is partially and cell lysis completely rescued (J:23560). Natural killer (NK) cells also release granzyme-bearing granules, and rapid cytoxicity by these cells is dependent on granzyme B. Granzyme B independent mechanisms of cytotoxicity exist, since CTLs from null homozygotes can lyse target cells after extended incubation, but these mechanism are not active in null mutant NK cells (J:28160).specific activity of caspase 3 executioner protease in cytoplasm of CTLs is decreaseddefective cytotoxic T cell cytolysis (J:23560)cytotoxic T lymphocytes (CTLs) defective in ability to induce rapid DNA fragmentation and apoptosis in allogeneic target cellswith long incubation, fragmentation is partially and cell lysis completely rescuednormal activation and proliferation of cytotoxic T lymphocytes (CTLs) in mixed lymphocyte cultures (MLCs)defective NK cell cytolysis (J:113213)impaired ability of NK cells to induce DNA fragmenting but normal ability to induce membrane damage",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2006-04-30","Cryopreserved sperm",90,0,"ANU","128","false",null,"Arno","Mullbacher","The Australian National University","arno.mullbacher@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[347,"C2f","B6;129S1-Cited2<tm1.1Dunw>/Apb","B6;129S1-Cited2<tm1.1Dunw>/Apb","Semi-dominant","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal","Cited2","Nil","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1.1, Sally L Dunwoodie","Cited2<tm1.1Dunw>","MGI:3696062","10",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Mice homozygous for the conditional allele of Cited2 are viable and no phenotype has been observed.","Normal","75% C57BL/6, 25% 129S1/Sv","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","2","2","Homozygous sib-matings to propagate the line in the homozygous state","No","2006-09-25","Cryopreserved sperm",106,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.unsw.edu.au",{"$nulls":3},"Sally","Dunwoodie","s.dunwoodie@victorchang.unsw.edu.au","N/A","N/A","No"]
[338,"Activin Beta C+ FL2","C57BL/6-Tg(ACTIVIN-β{C})3Grb/Apb",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":15},"No","human activin beta C","CMV","Greater than 20 copies, mRNA upregulated at least 3 fold in tissues assessed to date",{"$nulls":9},"Essenitally normal at gross level, male fertility decreased from 10 weeks (decreased sperm production and litter size), liver disease (mild fibrosis) from 14 weeks, prostate hyperplasia from 20 weeks.","Essenitally normal at gross level, male fertility decreased from 14 weeks (decreased sperm production and litter size), liver disease (mild fibrosis), prostate hyperplasia from 25 weeks.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Good",null,"3","het x wt OR het x het","No","2006-09-20","Cryopreserved sperm",55,0,null,null,"false",null,"Gail","Risbridger","Monash University","gail.risbridger@med.monash.edu.au",{"$nulls":3},"Elspeth","Gold","gail.risbridger@med.monash.edu.au","A.BS.01.09","N/A","No"]
[1494,"B6.C1q-/-","B6;129S-C1qa<tm1Mjw>/Apb","B6;129S-C1qa<tm1Mjw>/Apb","Recessive","complement component 1, q subcomponent, alpha polypeptide","C1qa","Nil","C1q","MGI:88223","complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport","C1qa<tm1Mjw>","MGI:2158701","4",{"$nulls":15},"No",{"$nulls":12},"Premature death: 15% die at 4 - 6 months of ageIncreased anti-nuclear antigen antibody level:* mutants develop high titers of anti-nuclear antibodiesIncreased anti-histone antibody level.Glomerulonephritis:* Background Sensitivity: severe proliferative crescentic glomerulonephritis evident in 27% mice.* Background Sensitivity: striking feature is presence of multiple apoptotic bodies in diseased glomeruli.* among mutants without glomerulonephritis, significantly greater numbers of glomerular apoptotic bodies are seen than in controls.Increased susceptibility to bacterial infection:* animals challenged with virulent pneumococci develop bacteremia and pneumonia after passive immunization with human IgG1 or human IgG2 unlike wild-type mice that are protected after immunization.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-07-03","Cryopreserved sperm",136,0,"ANU","020","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[631,"Pkr KO","B6;129-Eif2ak2<tm1Cwe>/Apb","B6;129-Eif2ak2<tm1Cwe>/Apb","Recessive","eukaryotic translation initiation factor 2-alpha kinase 2","Eif2ak2","Nil","dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, Eif2ak2, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Pkr, Prkr, Tik","MGI:1353449","targeted mutation 1, Charles Weissmann","Eif2ak2<tm1Cwe>","MGI:2182566","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.  Enlarged lymph nodes. Altered susceptibility to viral infection.increased T cell proliferation.Proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increasedabnormal inflammatory mediator physiology.A 2 fold increase in Il4 production by CD44+ cellsincreased susceptibility to viral infection.Susceptibility to encephalomyocarditis virus testedresponse to infection and survival were similar to control mice; however, pretreatment of mice with IFNgamma failed to improve survival as it did in controlsincreased susceptibility to type IV hypersensitivity reaction. Exaggerated response to challenge after presensitization in contact hypersensitivity testeffect can be transferred to naive mice using CD8+ cells from sensitized mice.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent",null,null,"Hom x Hom","No","2007-04-25","Cryopreserved sperm",96,0,null,null,"false",null,"Bryan","Williams","Monash University","bryan.williams@med.monash.edu.au",{"$nulls":3},"Aneta","Dowsing","Aneta.dowsing@med.monash.edu.au","N/A","N/A","No"]
[778,"MPDtg","C57BL/6-Tg(Ckm-hPDGF-BB)/Apb",null,"Dominant",{"$nulls":25},"human platelet derived growth factor receptor b","a mouse muscle creatine kinase 6.5-kb enhancer/promoter/first intron segment",{"$nulls":10},"Transgenic mice that specifically express the PDGF receptor in skeletal muscle. In these mice, PDGF stimulated glucose transport into skeletal muscle in vitro and in vivo. The degree of glucose uptake in vivo reached ∼60% of that by insulin injection in skeletal muscle, but blood glucose levels were not decreased by PDGF in these mice. ",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-18","Cryopreserved sperm",50,0,null,null,"false",null,"David","James","Garvan Institute","d.james@garvan.org.au",{"$nulls":3},"David","James","d.james@garvan.org.au","N/A","N/A","No"]
[5419,"IL21 KO NOD","NOD.129-IL21<tm1Lex>/Apb",null,"Recessive","interleukin 21","Il21","Nil",null,"MGI:1890474","targeted mutation 1, Lexicon Genetics","Il21<tm1Lex>","MGI:3528994","3",{"$nulls":15},"No",{"$nulls":12},"Protected from diabetes on NOD background.Decreased germinal center B cell number:* the percentage of GC B cells that make up the total B cell population in the spleen of immunized mice is reduced by two-thirdsAbnormal CD4-positive T cell morphology:* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Abnormal spleen germinal center morphology:* the number of actively proliferating T cells found within GC is reduced 3- to 4- fold.* the percentage of follicular T helper cells (defined as CXCR5+ICOS+CD4+ T cells) is reduced by a third.Decreased spleen germinal center number:* there is a paucity of GC in the spleen of mice after immunization with sheep red blood cells (SRBC).Decreased CD4-positive T cell number:* Il-17+ CD4+ cells are absent from lamina propria and spleen in mutants.Abnormal T cell differentiation:* when naive TH cells are subjected to TH17 differentiation, a deficit in generation of Il-17-producing cells is observed with an increased number of Foxp3+ cells compared to wild-type.* one week after immunization with MOG peptide in CFA, restimulation of spleen cells with TPA or MOG peptide results in production of almost no Il-17 producing cells, showing impaired TH17 differentiation.Abnormal gamma-delta T cell morphology:*lamina propria and splenic TCRgd+ T cells show <10-fold decrease in Il-17-expressing cells compared to wild-type cells.Abnormal interleukin level:* CNS-infiltrating and splenic CD4+ T cells produce interferon gamma, in contrast to CD4+ T cells from controls which produce predominantly Il-17.","Normal","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","10","0","intercross hets to derive homozygous for experiments","No","2011-02-04","Cryopreserved sperm",60,0,"ABR - Moss Vale",null,"false",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au","384 Victoria Street","Darlinghurst","NSW","Helen","McGuire","h.mcguire@garvan.org.au","08/29","1701/2005","No"]
[1526,"B6.LMP2-/-","B6.129P2-Psmb9<tm1Stl>/AnuApb",null,"Recessive","proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)","Psmb9","Nil","Lmp-2, Lmp2","MGI:1346526","targeted mutation 1, Susumu Tonegawa","Psmb9<tm1Stl>","MGI:2152729","17",{"$nulls":15},"Yes",{"$nulls":12},"Mice homozygous for disruptions in this gene have a grossly normal phenotype but suffer from increased susceptibility to some viruses and have an increased risk of tumor development.Decreased CD8-positive T cell number:* by 36% in blood* by 22% in spleen* by 49% in thymusAbnormal CD8-positive, alpha-beta cytotoxic T cell morphology :* 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virusAbnormal immune system physiology:* splenic lymphoblasts and peritoneal exudates cells are less efficient stimulators of CD8+ T cells.Increased susceptibility to viral infection:* 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus.",null,"C57BL/6 x 129S2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Brother x Sister","No","2007-07-05","Cryopreserved sperm",150,0,"ANU","104","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[8744,"ASD572:Shn-2 KO:AIRE KO","B6.Cg-Aire<tm1Pltn> Hivep2<tm1Sis>/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Pltn>","MGI:2182940","10",{"$nulls":28},"unknown","unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-02","Cryopreserved sperm",55,0,"ANU",null,"true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[1626,"C2X1f","129X1;129S1-Cited2<tm1.1Dunw>/Apb","129X1;129S1-Cited2<tm1.1Dunw>/Apb","Recessive","Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2","Cited2","Normal","ER154-like, Mrg1, Msg2, p35srj","MGI:1306784","targeted mutation 1.1, Sally L Dunwoodie","Cited2<tm1.1Dunw>","MGI:3696062","10",{"$nulls":15},"No",{"$nulls":12},"Normal","None","129X1/SvJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3","0","Backcrossed into 129X1/SvJ to increase health as ES origin is not as viable.","No","2007-07-16","Cryopreserved sperm",200,0,"Victor Chang",null,"false",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":3},"Jost","Preis","j.preis@victorchang.edu.au","N/A","N/A","No"]
[2355,"Patel","B6.129S2-Cd28<tm1Mak> Tg(TcrLCMV)327Sdz Tcra<tm1Mom>/AnuApb",null,"Recessive","CD28 antigen","CD28","Nil","Tcr alpha, Tcralpha","MGI:88327","targeted mutation 1, Tak Mak","Cd28<tm1Mak>","MGI:1857150","1",{"$nulls":15},"Yes","transgene insertion 327, Birgit Ledermann",null,"High",{"$nulls":9},"Homozygous mutation of this CD28 results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-11","Cryopreserved sperm",25,0,"ANU","015","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[2355,"Patel","B6.129S2-Cd28<tm1Mak> Tg(TcrLCMV)327Sdz Tcra<tm1Mom>/AnuApb",null,"Recessive","T-cell receptor alpha chain","Tcra","Unknown","Tcr alpha, Tcralpha","MGI:98553","targeted mutation 1, Peter Mombaerts","Tcra<tm1Mom>","MGI:1857255","14",{"$nulls":58},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A"]
[2476,"Toll 3 Receptor, Pkr double KO","B6.129-Tlr3<tm1Flv> Eif2ak2<tm1Cwe>/MarpApb",null,"Recessive","toll-like receptor 3","Tlr3","Nil","2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, Eif2ak2, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Pkr, Prkr, Tik","MGI:2156367","toll-like receptor 3; targeted mutation 1, Richard A Flavell","Tlr3<tm1Flv>","MGI:2653138","8",{"$nulls":15},"Yes",{"$nulls":12},"Splenomegaly developing between 8 and 10 weeks of agewas observed in tlr3<-/-> and tlr3<-/-> pkr<-/-> mice.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Excellent",null,null,"Hom x Hom","No","2008-01-18","Cryopreserved sperm",100,0,"Monash",null,"false",null,"Aneta","Dowsing","Monash University","Aneta.dowsing@med.monash.edu.au",{"$nulls":3},"Aneta","Dowsing","Aneta.dowsing@med.monash.edu.au","N/A","N/A","No"]
[2352,"Tg (F5 TCR)","B6.SJL-Ptprc<a>Pep3<b> Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/AnuApb",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc","Unknown","B220, CD45, CD45 antigen, Cd45, Ly-5, Lyt-4, T200, lymphocyte antigen 5","Ptprc","Ptprc<a>",null,null,"1",{"$nulls":15},"Yes","transgene insertion 1, Dimitris Kioussis","CD2 minigene",{"$nulls":10},"Transgenic mice have TCRs recognizing, in the context of D<b>, a peptide of the influenza virus A/NT/60/68 nucleoprotein [NP-(366-379)].  ",null,"SJL/JxC57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-12-11","Cryopreserved sperm",80,0,"ANU","012","true",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8360,"ASD866","C57BL/6NCrlAnu:Orange",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04",null,0,0,"ANU","866","true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":8},"No"]
[2474,null,"B6.129-Bmi1<tm1Brn>/WehiApb",null,"Recessive","Bmi1 polycomb ring finger oncogene","Bmi1","Nil","Bmi-1, Bmi1, Pcgf4","MGI:88174","targeted mutation 1, Anton Berns","Bmi1<tm1Brn>","MGI:1857632","2",{"$nulls":15},"Yes",{"$nulls":12},"Homozygous null mutants display decreased hematopoietic cell number, immune deficiency, neurological abnormalities, and posterior transformation, while transgenic overexpressing mice show an opposite dose-dependent anterior transformation of vertebral identity.Postnatal lethality.","Vertebral transformation",null,"No","No","Yes","No","No","Yes","No","Poor",{"$nulls":3},"No","2008-01-18","Cryopreserved sperm",150,0,"WEHI",null,"false",null,"Marnie","Blewitt","Walter and Eliza Hall Institute of Medical Research","blewitt@wehi.edu.au",{"$nulls":3},"Marnie","Blewitt","blewitt@wehi.edu.au","N/A","N/A","No"]
[8750,"Gsdmd KO","C57BL/6N-Gsdmd<em1Gne>/GneAnu",null,"Recessive","gasdermin D","Gsdmd",null,"1810036L03Rik, DF5L, Dfna5l, Gsdmdc1, M2-4","MGI:1916396","gasdermin D; endonuclease-mediated mutation 1, Genentech","Gsdmd<em1Gne>","MGI:6259809","15",{"$nulls":30},"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-09",null,0,0,"ANU",null,"false",null,"Si Ming","Man","Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[2772,"BALB/c.Flii<+/+> FLII<c17.8/+> ; FIT","BALB/c-Tg(FLII)2Hdc/AnuApb","BALB/c-Tg(FLII)2Hdc","Dominant",{"$nulls":25},"Human Flightless gene","Human Flightless",{"$nulls":10},"Ubiquitous expression of human Flightless protein",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het x wt BALB/c","No","2008-02-16","Cryopreserved sperm",80,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[2779,"C57BL/6.hK14-FLII 5","C57BL/6-Tg(hK14-FLII)5/AnuApb",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","Human Flightless","Human Keratin 14",{"$nulls":10},"Not bred to Homozygous state","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","5",null,"Het FLII transgenic x WT C57BL/6","No","2008-02-16","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Hugh","Campbell","ruth.arkell@anu.edu.au","N/A","N/A","No"]
[8751,"Db","B6-Lepr<db>/AnuApb",null,"Recessive","leptin receptor","Lepr",null,"Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP","MGI:104993","leptin receptor; diabetes","Lepr<db>","MGI:1856009","4",{"$nulls":28},"ObesityDiabetes",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2019-07-17","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Charmaine","Simeonovic","Australian National University","Charmaine.Simeonovic@anu.edu.au",{"$nulls":8},"No"]
[4196,null,"NOD.129P2/Ola-Csf2<tm1Ard>/WehiApb","NOD.129P2/Ola-Csf2<tm1Ard>/WehiApb","Recessive","colony stimulating factor 2 (granulocyte-macrophage)","Csf2","Nil","Csfgm, Gm-CSf, MGI-IGM","MGI:1339752","targeted mutation 1, Ashley R Dunn","Csf2<tm1Ard>","MGI:1930997","11",{"$nulls":15},"Yes",{"$nulls":12},"These mice may develop diabetes beginning at around 12 weeks of age. When these mice are used for incidence curves, the longest they are kept alive is 300 days.Mice develop pulmonary pathology from 10 weeks onwards. They are more susceptible to lung infections caused by bacterial or fungal organisms.","Phenotype as for wild type NOD/Lt mice- develop type 1 diabetes starting around 12-15 weeks of age","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","16","2","sib x sib","No","2008-12-20","Cryopreserved sperm",135,0,null,null,"false",null,"Ashley","Dunn","The University of Melbourne","dunna@unimelb.edu.au",{"$nulls":3},"Thomas","Kay","tkay@svi.edu.au","N/A","N/A","No"]
[3395,"C3H/HeJARC","C3H/HeJArcApb","C3H/HeJArcApb","Recessive","toll-like receptor 4","Tlr4",null,"lipopolysaccharide response, Lps, Rasl2-8","MGI:96824","toll-like receptor 4; wild type revertant","Tlr4<Lps-d+>","MGI:4943781","4",{"$nulls":15},"Yes",{"$nulls":42},"Mathew","Martin-Iverson","Mathew@cyllene.uwa.edu.au","N/A","N/A"]
[4449,null,"C57BL/6-Gpx4<tm1Prol>/Apb",null,"Dominant","glutathione peroxidase 4","Gpx4","Reduced","mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase","MGI:104767","targeted mutation 1, Tomas A Prolla","Gpx4<tm1Prol>","MGI:2651590","10",{"$nulls":15},"No",{"$nulls":12},"Lethality/Prenatal-PerinatalEmbryonic lethality before somite formation * embryos die around E7.5Embryogenesis*Failure to gastrulate*Abnormal triploblastic development","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Good",{"$nulls":3},"No","2009-02-20","Cryopreserved sperm",100,0,null,null,"false",null,"Ian","Trounce","St Vincent's Institute","i.trounce@unimedlb.edu.au",{"$nulls":3},"Ian","Trounce","ianat@medstv.unimelb.edu.au","N/A","N/A","No"]
[4454,null,"C57BL/6-Tg(CD2-IL5)5C2Ldt/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia. Northern blot analysis identified 11,5 mRNA in the thymus, Peyer's patches, and subcutaneous (pooled inguinal and axillary) lymph nodes. No IL5 mRNA was detected in liver, heart, brain, or skeletal muscle tissues from transgenics, nor in any tissues from normal littermates. Do not maintain as homozygotes. While this is apparently possible, survival of homozygotes likely to be lower. These mice appeared macroscopically normal apart from splenomegaly. Eosinophils were at least 65- and 265-fold higher in blood from transgenics, relative to normal littermates, and approximately two- or sevenfold more numerous relative to blood from mice infected with the helminth Mesocestoides corti. Much more modest increases in blood neutrophil, lymphocyte, and monocyte numbers were noted in transgenics, relative to normal littermates (less than threefold). Thus IL-5 in vivo is relatively specific for the eosinophil lineage. Large numbers of eosinophils were present in spleen, bone marrow, and peritoneal exudate, and were highest in the line with the greatest transgene copy number. Eosinophilia was also noted in histological sections of transgenic lungs, Peyer's patches, mesenteric lymph nodes, and gut lamina propria but not in other tissues examined. IL-5 was detected in the sera of transgenics at levels comparable to those seen in sera from parasite-infected animals.","Appear normal with peripheral blood eosinophilia and increased numbers of eosinophils in the spleen (with splenomegaly), bone marrow. Heterozygous BALB/c and C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",null,null,"Transgenic male with wild type female","No","2009-02-20","Cryopreserved sperm",50,0,"ANU","065","false",null,"Paul","Foster","The University of Newcastle","paul.foster@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5443,"NODGrzA","NOD.B6-Gzma<tm1Simn>/LtJApb",null,"Dominant","granzyme A","Gzma","Nil","BLT esterase, Ctla-3, Ctla3, H factor, Hanukah factor, Hf, SE1, serine esterase 1, TSP-1, TSP1","MGI:109266","granzyme A; targeted mutation 1, Markus M Simon","Gzma<tm1Simn>","MGI:2449926","13",{"$nulls":15},"No",{"$nulls":12},"Mice are healthy and develop normally, but develop diabetes at a slightly accelerated rate compared to NOD/Lt mice.","Mice are healthy and develop normally, but will develop diabetes similar to NOD/Lt mice.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","11","5","Sister X Brother","Yes","2011-02-23","Cryopreserved sperm",50,0,"St V",null,"false",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au","9 Princes St","Fitzroy","Vic","Stacey ","Fynch","sfynch@svi.edu.au","043/08, SABC025","073","Yes"]
[4533,"Drasic -/-","B6.129-Asic3<tm1Wsh>/Apb",null,"Recessive","acid-sensing (proton-gated) ion channel 3","Asic3","Unknown","Accn3, DRASIC","MGI:2159339","acid-sensing (proton-gated) ion channel 3; targeted mutation 1, Michael J Welsh ","Asic3<tm1Wsh>","MGI:2429689","5",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors.  Hyperglasia- at site of injury (carrageenan-induced inflammation), mice showed increased sensitivity to mechanical stimuli, but not to noxious thermal stimulus. Responses to somatosensory stimuli under normal conditions were similar to wild-type littermates",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-02-27","Cryopreserved sperm",100,0,null,null,"false",null,"Ashley","Blackshaw","Hanson Institute","Ashley.blackshaw@health.sa.gov.au",{"$nulls":3},"Ashley","Blackshaw","Ashley.blackshaw@health.sa.gov.au","N/A","N/A","No"]
[4785,"Line3","FVB-Tg(HBA1-GFP)3Ew/Apb",null,"Dominant",null,null,"Increased",{"$nulls":5},"Unknown",{"$nulls":15},"No","transgene insertion 3, Emma Whitelaw","α-Globin (-570 to +37) (4.1kb of enhancer)","36 copies",{"$nulls":9},"Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation.","Fluorescence in erythrocytes can be observed by FACS or fluorescent microscopy. The allele is subject to variegation","FVB","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,null,"Hom x Hom","No","2009-09-06","Cryopreserved sperm",150,0,"QIMR",null,"false",null,"Emma","Whitelaw","Queensland Institute of Medical Research","emma.whitelaw@qimr.edu.au",{"$nulls":3},"Emma","Whitelaw","emma.whitelaw@qimr.edu.au","A.BS.01.09","N/A","No"]
[4769,"C57BL/6J.i-K<btm1>","C57BL/6-H2-K1<tm1Bpe>/AnuApb",null,"Recessive","histocompatibility 2, K1, K region","H2-K1","Unknown","H2-K1tm1Bpe","MGI:95904","targeted mutation 1, Beatrice Perarnau","H2-K1<tm1Bpe>","MGI:1931444","17",{"$nulls":15},"Yes",{"$nulls":12},"increased CD4-positive T cell number: numbers increase in parallel to decrease in CD8+ cells.decreased CD8-positive T cell number: 30-50% reduction of single positive CD8<+> peripheral T cells.Abnormal susceptibility to viral infections",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10","2","Sib x sib","No","2009-05-06","Cryopreserved sperm",150,0,"ANU","120","false",null,"Guna","Karupiah","The Australian National University","guna.karupiah@anu.edu.au",{"$nulls":3},"Guna","Karupiah","guna.karupiah@anu.edu.au","N/A","N/A","No"]
[4786,"Blades","C.129-IL5<tm1Kopf> Eotaxin<tm1Mer>/AnuApb",null,"Recessive","interleukin 5","Il5","Unknown","Il-5","MGI:96557","targeted mutation 1, Manfred A Kopf","Il5<tm1Kopf>","MGI:1861948","11",{"$nulls":15},"Yes",{"$nulls":12},"Unknown",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2009-09-06","Cryopreserved sperm",125,0,"ANU","051","false",null,"Paul","Foster","The Australian National University","paul.foster@anu.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","A.BS.01.09","N/A","No"]
[5454,"Phc2","C57BL/6-Phc2<tm1Hko>/WehiApb",null,"Recessive","polyhomeotic-like 2 (Drosophila)","Phc2","Nil","Edr2, Mph2","MGI:1860454","polyhomeotic-like 2 (Drosophila); targeted mutation 1, Haruhiko Koseki","Phc2<tm1Hko>","MGI:3586989","4",{"$nulls":28},"Minor skeletal abnormalities. Female infertilityAbnormal axial skeleton morphology: * all homozygotes have at least a few alterations to the axial skeleton characteristic of posterior transformations; however, the skull is similar to wild-type. * an ectopic bone floats between the occipital bones and the first cervical vertebra.Abnormal rib morphology.Increased rib number: ectopic ribs are associated with C7 in 67% of homozygotes.Rib fusion: C7 ectopic ribs are imperfect and fused to the middle part of the first ribs; the rest of the ribs are perfect and directly associated with the cranially shifted sternum.Abnormal sternum morphology: the sternum is shifted cranially.Asymmetric rib-sternum attachment: the 7th rib pair are detached from the sternum and the 13th rib pair are missing or floating.Fusion of atlas and odontoid process: the odontoid process is fused to the first cervical vertebra (C1).Split cervical atlas: the dorsal part of the C1 is often bifurcated.Split cervical axis: the dorsal part of C2 is often bifurcated.Vertebral transformation: the thoracolumbar and lumbosacral boundaries are shifted anteriorly.Thoracic vertebral transformation: a prominent spinous process normally associated with the second thoracic vertebra (T2) is associated with T1 in all homozygotes.Cervical vertebral transformation: in the lateral view C2 resembles C3.Decreased cell proliferation: MEFs grow more slowly and stop dividing earlier.","Normal","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good","10",null,"Het x WT or Het x Het or Hom male x Het or WT female","No","2011-03-03","Cryopreserved sperm",60,0,"WEHI",null,"false",null,"Marnie","Blewitt","Walter and Eliza Hall Institute of Medical Research","blewitt@wehi.edu.au",{"$nulls":3},"Marnie","Blewitt","blewitt@wehi.edu.au","N/A","N/A","No"]
[5484,"MPSIIIA-GFP","B6.Cg-Sgsh<mps3a> Tg(UBC-GFP)30Scha/JApb",null,"Recessive","N-sulfoglucosamine sulfohydrolase (sulfamidase)","Sgsh","Reduced","sulphamidase","MGI:1350341","N-sulfoglucosamine sulfohydrolase (sulfamidase); mucopolysaccharidosis IIIA","Sgsh<mps3a>","MGI:2151181","11",{"$nulls":15},"Yes","transgene insertion 30, Brian Schaefer","Human ubiquitin C","Increased",{"$nulls":9},"The phenotype of the mice has not been fully characterised but is expected to be similar to MPS IIIA mice that do not express the GFP gene (Crawley et al (2006) Brain Research 1104:1-17). Newborn MPS IIIA-GFP mice are no different to their unaffected counterparts. It is not until around 10 weeks of age that we begin to see increased aggression in MPS IIIA-GFP males.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Homozygous x homozygous","No","2011-04-15","Cryopreserved sperm",50,0,null,null,"false",null,"Kim","Hemsley","Women's and Children's Hospital, Adelaide","kim.hemsley@adelaide.edu.au","72 King William Road, North Adelaide","Adelaide","South Australia",{"$nulls":3},"835/6/2013","B0098/0310","No"]
[7683,"TG2KI.B6","B6.Cg-Tgm2<tm2.1Rmgr>/Apb","MGI:5521582","Recessive","transglutaminase 2, C polypeptide","Tgm2","Normal","G[a]h, protein-glutamine gamma-glutamyltransferase, TG C, TG2, tissue transglutaminase, tTG, tTGas","MGI:98731","targeted mutation 2.1, Robert M Graham","Tgm2<tm2.1Rmgr>","MGI:5521582","2",{"$nulls":15},"No",{"$nulls":12},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","Maintained on C57BL/6J","N/A","Het x het matings","No","2014-05-15","Cryopreserved sperm",50,0,"Victor Chang",null,"false",null,"Siiri","Iismaa","Victor Chang Cardiac Research Institute","s.iismaa@victorchang.unsw.edu.au",{"$nulls":3},"Siiri","Iismaa","s.iismaa@victorchang.unsw.edu.au","12_29","NLRD3015-2010","No"]
[4916,"IL-4ra -/-","BALB/c-IL4ra<tm1Sz>/AnuApb",null,"Recessive","interleukin 4 receptor, alpha","Il4ra","Unknown","CD124, IL-4 receptor alpha chain, Il4r","MGI:105367","targeted mutation 1, Leonard Shultz","Il4ra<tm1Sz>","MGI:1861951","7",{"$nulls":28},"Abnormal microglial cell morphology:microglial cells fail to express the cell marker Ym1 (Chi3l3)Decreased IgE level:lower circulating levels of IgE in normal and bacterial infected miceDecreased IgG1 level:lower circulating levels in normal and bacterial infected miceIncreased IgG2a levelAbnormal T-helper 2 physiology:mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cellsDecreased interleukin-10 secretion:decrease production by T cells from mice infected with N. brasiliensis bacteriaDecreased interleukin-4 secretion:decrease production of IL-4 by T cells from mice infected with N. brasiliensis bacteriaDecreased interleukin-5 secretion:decrease production of IL-5 by T cells from mice infected with N. brasiliensis bacteria",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-10-16","Cryopreserved sperm",100,0,"ANU","058","false",null,"Paul","Foster","The University of Newcastle","paul.foster@newcastle.edu.au",{"$nulls":3},"Alistair","Reid","alistair.reid@anu.edu.au","A.BS.01.09","N/A","No"]
[4940,"Linie 659","Swiss-Tg(tPA-LacZ)659/MarpApb",null,"Dominant",{"$nulls":25},"Beta-galactosidase","9.5kb of human t-PA gene promoter",{"$nulls":10},"Normal.Expression of LacZ in brain. Very high expression in hippocampus, dentate gyrus and cortex.",null,"Swiss white","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",null,null,"Tg Het x WT Swiss white","No","2009-12-04","Cryopreserved sperm",40,0,"Monash",null,"false",null,"Robert","Medcalf","Monash University","Robert.medcalf@med.monash.edu.au",{"$nulls":3},"Robert","Medcalf","Robert.medcalf@med.monash.edu.au","E/0321/2004/M","N40/03","No"]
[5065,"Zic5 V504G: C3H/HeH","C3H.C-Zic5<V504G>/AnuApb",null,"Recessive","Zinc finger protein of the cerebellum 5","Zic5","Unknown","odd-paired related, Opr","MGI:1929518",{"$nulls":3},"14",{"$nulls":15},"Yes",{"$nulls":12},"Viable and fertile","Viable and fertile","C3H/HeH","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"Homozygote male paired with homozygote female","No","2010-03-25","Cryopreserved sperm",40,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":3},"Anna ","Chappell","anna.chappell@anu.edu.au","R.MG.11.08 ","N/A","No"]
[4959,"K5-crePR1 , K5crePR1 ; K5C","C(Cg)-Tg(KRT5-cre/PGR)1Der/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, Dennis R Roop","bovine keratin 5",{"$nulls":10},"To activate or inactivate conditional alleles in murine stratified epithelia, a novel system has been developed. It is based on the generation of transgenic mice that express an inducible Cre recombinase under the control of a promoter specific for stratified epithelia. The inducible features of Cre were achieved by fusing Cre to a deletion mutant of the human progesterone receptor (PR), which fails to bind progesterone but can be activated by progesterone antagonists, such as RU486. This fusion protein (CrePR1) is sequestered in the cytoplasm. After activation with RU486, CrePR1 translocates to the nucleus, where it mediates the excision of DNA sequences flanked by LoxP sites. Mice generated express CrePR1 under the control of the K5 which is expressed in the basal cells of stratified epithelia",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2010-01-12","Cryopreserved sperm",138,0,"ANU",null,"false",null,"Ruth","Arkell","The Australian National University","ruth.arkell@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4987,"BYAC","B6.SJL-Tg(YACA201F4)/Apb",null,"Dominant",{"$nulls":25},"human β-globin locus","β-globin",{"$nulls":10},"Transgenic human β-globin locus expression was limited to spleen and blood.To establish the pattern of expression of the transgenichuman β-globin locus during development, RNA was analyzedby primer extension. At day 8.5, the first human gene expressed was the foetal γ-globin gene. In day 10.5 yolk sac, the percentage of γ-globin mRNA decreased, while theε-globin mRNA level increased, and this trend continued on day 11.5. At day 12.5, expression of the ε-globin gene hadlargely been switched off. There is an abrupt shift to β-globingene expression that exceeds the level of γ-globin mRNA.Human β-globin expression continued to increase at day 14.5as the dominant globin mRNA. Quantitation by Phosphorlmageranalysis revealed that the ratio of adult mouse toadult human β-globin gene activity per gene copy was 1.35.Thus, the expression level of the single, integrated humanβ-globin locus was comparable to that of the endogenousmurine β-globin locus. The pattern of ε- and β-globin geneactivity followed the expression of the mouse embryonic andadult genes, respectively. However, expression ofthe humanγ-globin gene preceded ε-globin gene expression at day 8.5and persisted throughout the fetal stage. In adult transgenicanimals, low-level human fetal gene expression was occasionally detected. This may be a consequence of theextreme erythroid hyperplasia observed after treatment withphenylhydrazine.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-01-28","Cryopreserved sperm",100,0,null,null,"false",null,"Andrew","Perkins","The University of Queensland","a.perkins@imb.uq.edu.au",{"$nulls":3},"The Australian","Phenomics Facility","contact@australianphenomics.org.au","N/A","N/A","No"]
[7786,"Dynll-KO","C57BL/6-Dynll1<tm1.2Jhh>/StvApb",null,"Dominant","dynein light chain LC8-type 1","Dynll1","Nil","8kDa LC, DLC8, Dnclc1, Pin","MGI:1861457","dynein light chain LC8-type 1; germline knockout 1.2, Jorg Heierhorst","Dynll1<tm1.2Jhh>",null,"5",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"Yes",{"$nulls":12},"Embryonic Lethal","Normal","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent",{"$nulls":3},"No","2014-11-17","Cryopreserved sperm",50,0,"St V",null,"false",null,"Jorg","Heierhorst","St Vincent's Institute","jheierhorst@svi.edu.au",{"$nulls":3},"Ashleigh","King","aking@svi.edu.au","019/13","069","No"]
[5146,"Aire KO","B6.129-Aire<tm1Pltn>/AnuApb",null,"Recessive","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)","Aire","Nil",null,"MGI:1338803","autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 1, Leena Peltonen","Aire<tm1Pltn>","MGI:2182940","10",{"$nulls":15},"No",{"$nulls":12},"Targeted mutations that inactivate the gene result in immune system dysfunction characterized by multiorgan lymphocytic infiltration and circulating autoantibodies.Absent adrenal gland: absence of the adrenal glands is seen with incomplete penetrance; however, the thyroid and pancreas are normal.Abnormal T cell morphology: the TCR-Vbeta repertoire is altered in peripheral T cells.Increased T cell proliferation: immunization with hen egg lysozyme antigen results in a 4-5-fold increase in proliferating response of peripheral T cells, with mutants showing twice as many T cells in the lymph nodes than controls.Thymus atrophy: thymic atrophy is seen in 2 of 14 mutants.Increased autoantibody level: 73% of homozygous mice generated autoantibodies against at least one of the organs (liver, testis, pancreas and adrenal gland) tested and 40% of mice contain autoantibodies against two or more of the organs.Liver inflammation: 50% of mutants exhibit accumulation of lymphocytes in periportal regions.Infertility: 85% of male or female mutants fail to produce any litters.",null,"C57BL/6","Yes","No","Yes","Yes","No","Yes","No","Poor",{"$nulls":3},"No","2010-06-02","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au","Building 131, Garran Road","Acton","ACT","Stuart","Read","stuart.read@anu.edu.au","J.APF.21.08","N/A","No"]
[5160,"NODCD19cre","NOD.129-Cd19<tm1(cre)Cgn>/MarpApb",null,"Dominant","CD19 antigen","Cd19","Nil",null,"MGI:88319","CD19 antigen; targeted mutation 1, University of Cologne","Cd19<tm1(cre)Cgn>","MGI:1931143","7",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"No CD19 expression.Decreased B-1 B cell number: reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo).Abnormal B cell differentiation.Absent spleen germinal center: failure of germinal center formation.Abnormal B cell physiology: impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate.Abnormal immunoglobulin level: failure of affinity maturation of serum antibodies.Decreased IgE level.Decreased IgG1 level: absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate.Decreased IgM level: reduction in serum IgM.","Mice express Cre recombinase under the control of Cd19 promoter, B cell specific.","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",">10",null,null,"No","2010-06-28","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Robyn","Slattery","Monash University","robyn.slattery@monash.edu","Dept Immunology, 2nd floor Monash bldg, Alfred Hospital, Commercial Rd,","Prahran","Victoria","Robyn","Slattery","Robyn.Slattery@monash.edu","E/0867/2009M","PC1-N42/07","No"]
[5557,"T16; IL1RA T16OX","B6;CBA-Tg(Il1rn)1Dih/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, David Hirsh","IL1RA promoter",{"$nulls":10},"Increased circulating interleukin-1 level: serum IL-1 levels are higher following lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection.","Abnormal angiogenesis: reduced angiogenesis observed in stromal keratitis caused by herpes simplex virus (HSV) ocular infection, reduced vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) levels.Decreased circulating interleukin-6 level: reduced IL-6 levels in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Abnormal circulating serum amyloid protein level: 30% decrease in serum amyloid P levels after subcutaneous turpentine administration.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.Decreased inflammatory response: reduced polymorphonuclear leukocyte infiltration in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Decreased susceptibility to viral infection: severity of stromal keratitis caused by herpes simplex virus (HSV) ocular infection is diminished.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12","Cryopreserved sperm",95,0,"ANU",null,"false",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[5577,"∆SRI ","C.129T2-Atm<tm1Mfl>/QimrApb",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Reduced","C030026E19RIK","MGI:107202","ataxia telangiectasia mutated homolog (human); targeted mutation 1, Martin F Lavin","Atm<tm1Mfl>","MGI:2181756","9",{"$nulls":28},"Premature death: 50% mortality by 40 weeks of age Decreased body size: smaller size persists through adulthood Postnatal growth retardation: 20% growth reduction in males and 18% reduction in females from birth to 45 days of age. Increased tumor incidence: mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas Thymic lymphoma: found in all mice dying before 40 weeks, diverse cell types involved, spongy tumors with a high proportion of cells undergoing apoptosis Abnormal immune system cell morphology: occasional increase in thymocyte size. Abnormal T lymphocyte development: lymph node T cells are primarily at early stages of development. Increased double-negative T cell count: occurs at random Abnormal effector T cell morphology/development: randomly observed increases in single positive T cells. Decreased thymocyte number: 10% reduction in thymocytes, 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3. Abnormal immune system organ morphology: enlarged spleen: usually found in mice dying after 40 weeks of age. small spleen: in mice under 40 weeks of age small thymus small lymph nodes Abnormal chromosome morphology: 3 fold increase in radiation induced chromosomal aberrations. Increased cellular sensitivity to ionizing radiation: increased sensitivity of thymocytes and splenocytes to ionizing radiation. Seminiferous tubule degeneration: tubules disrupted Abnormal testis development: poorly developed Abnormal gametogenesis: abnormal oogenesis: disrupted, lack of maturing follicles and oocytes. Abnormal spermatogenesis: disrupted spermatogenesis, degenerating spermatocytes, loss of spermatids Nervous system phenotype: no gross neuronal degeneration at time points between 2 and 16 months of age. Abnormal Purkinje cell morphology: survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day, survival of cultured cells improves if cultured with cerebellar astroglial cells, develop simpler dendritic arboritization with reduced secondary branching, nitroxide free radicals improve survival and arborization Seminiferous tubule degeneration: tubules disrupted","Increased tumor incidence: average age at onset 18.6 months, varying tumor types including dermatoid cysts adenoma: 13% of total leukemia: 5% of total lymphoma:24% of total ovary tumor: 8% of total sarcoma: 32% of total, half of sarcomas are in Mammary glands","BALB/c","Yes","No","Yes","Yes","No","Yes","No","Good","22","14","Hetrezygotes x Heterozygotes","Yes","2011-09-05","Cryopreserved sperm",47,0,"QIMR",null,"false",null,"Martin","Lavin","Queensland Institute of Medical Research","martin.lavin@qimr.edu.au",{"$nulls":3},"Martin","Lavin","Martin.Lavin@qimr.edu.au","030400610","NLRD P178/2010 ","No"]
[5229,"Ripk2tm1Flv","C57BL/6-Ripk2<tm1Flv>/Apb",null,"Recessive","receptor (TNFRSF)-interacting serine-threonine kinase 2","Ripk2",null,"CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2","MGI:1891456","receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Richard A Flavell","Ripk2<tm1Flv>","MGI:2660793","4",{"$nulls":15},"No",{"$nulls":12},"Abnormal macrophage physiology:        * bone marrow derived macrophages produce less IL-6 and TNF when cultured in the presence of L. monocytogenes        * in macrophages pre-treated with TLR ligands (i.e. \"tolerized\"), macrophages produce significantly less inflammatory cytokines upon incubation with L. monocytogenes than controls that were LPS pre-treatedDecreased interleukin-6 secretion:        * bone marrow derived macrophages secrete half the amount of IL-6 as wild-type controls in response to culturing with L. monocytogenes        * IL-6 secretion is 22% that of controls when macrophages are pre-treated with LPS prior to L. monocytogenes incubation        * bone marrow derived macrophages fail to produce IL-6 when pre-treated with LPS prior to NOD2 stimulationDecreased tumor necrosis factor secretion:        * bone marrow derived macrophages secrete 61% TNF as wild-type controls in response to culturing with L. monocytogenes        * IL-6 secretion is about 20% that of controls when macrophages are pre-treated with LPS or LTA prior to L. monocytogenes incubation        * bone marrow derived macrophages fail to produce TNF when pre-treated with LPS prior to NOD2 stimulation","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-10-05","Cryopreserved sperm",50,0,null,null,"false",null,"Laercio R","Porto Neto","The University of Queensland","l.portoneto@uqconnect.edu.au",{"$nulls":6},"IMB/NRAVS/195/09/CRCBT (The University of Queensland)","IBC/592/NRAVS/2008 (The University of Queensland)","No"]
[8765,"F8 KO (72B)","C57BL/6-F8<tm1Csl>/72BCslApb",null,"Recessive","coagulation factor VIII","F8","Nil","Cf8, Cf-8, Factor VIII, FVIII","MGI:88383",{"$nulls":3},"X",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Mice are haemophilic as they are deficient in the clotting factor, FVIII.","Mice may be haemophilic.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[7696,"Spi6 conditional KO clone 1D","C57BL/6J-SerpinB9<tm2.1Pib>1D/PibMarpApb",null,"Dominant","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9",null,"ovalbumin, PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-06-09","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Monica","Prakash","Monash University","monica.prakash@monash.edu",{"$nulls":3},"Phillip","Bird","phil.bird@monash.edu","MARP/2014/034/BC","PC1","No"]
[243,null,"B6.129P2-Apoe<tm1Unc>/Arc",null,"Recessive","apolipoprotein E","Apoe","Nil",null,"MGI:88057","targeted mutation 1, University of North Carolina","Apoe<tm1Unc>","MGI:1857129","7",{"$nulls":15},"No",{"$nulls":12},"premature death (J:73202)35% dead by 18 monthscardiovascular systemincreased heart weight (J:108154)at 13 months, homozygotes show a 23% increase in heart weight relative to wild type mice (186 ? 7.1 vs. 151 ? 2.5 mg)cardiac hypertrophy (J:108154)at 13 months, homozygotes show a 59% increase in heart weight-to-body weight ratio relative to wild type miceabnormal aorta morphology (J:101576)at 24 weeks of age, homozygotes fed a normal diet (but not similarly-fed C57BL/6J control mice) show obvious atherosclerotic lesions in the aortic sinus and ascending aortathe number of atherosclerotic lesions in aortic sinus and ascending aorta is significantly increased in homozygotes fed an atherosclerotic diet vs a normal dietendothelial nitric oxide synthase (eNOS) in mutant aortic wall is distinctly reducedabnormal spiral modiolar artery morphology (J:101576)homozygotes fed an atherosclerotic diet develop atherosclerotic alterations in the spiral modiolar artery (SMA)in contrast, no such changes are detected in the SMA of homozygotes fed a normal dietspiral modiolar artery stenosis (J:101576)lumen stenosis of the spiral modiolar artery in the cochlea is exacerbated by an atherosclerotic diet relative to a normal dietarteriosclerosis (J:108154)homozygotes exhibit a 13% increase in aortic pulse-wave velocity (PWV) relative to wild type mice (428 ? 14.5 cm/s vs 379 ? 10.1 cm/s), indicating increased arterial stiffness and reduced vascular elasticityatherosclerotic lesions (J:73202, J:108154, J:97385, J:101576)advanced atherosclerotic lesions (J:73202)at 13 months, homozygotes display atherosclerotic lesions extending from the carotid arteries, heart, and aorta down to the renal arteries and the iliac bifurcation (J:108154)lesions are most severe in the proximal aorta and at the bifurcation of carotid arteries; the proximal carotid arteries are relatively free of lesions (J:108154)regular exercise does not reduce atherosclerotic lesion formation in homozygotes, as shown by a comparable % oil red-O staining of whole aortas from sedentary and exercised mutant mice (J:97385)at 24 weeks of age, homozygotes fed a normal diet (but not similarly-fed C57BL/6J control mice) show obvious atherosclerotic lesions in the aortic sinus and ascending aorta (J:101576)the number of atherosclerotic lesions in aortic sinus and ascending aorta is significantly increased in homozygotes fed an atherosclerotic diet vs a normal diet (J:101576)plaques in the luminal surface of the aorta are significantly larger in atherosclerotic diet homozygotes than in normal diet homozygotes (J:101576)increased susceptibility to atherosclerosis (J:101576)severity of atherosclerosis is 2-fold and 99-fold higher in atherosclerotic diet homozygotes than in normal diet homozygotes and C57BL/6J control mice, respectivelyvascular stenosis (J:101576)vascular stenosis is significantly increased in homozygotes fed an atherosclerotic diet vs a normal dietabnormal blood flow velocity (J:108154)anesthetized homozygotes show significantly increased transaortic blood velocities relative to wild type mice with peak aortic velocity at 133.4 ? 7.8 cm/s vs 89.2 ? 5.8 cm/s, and mean aortic velocity at 35.9 ? 2.7 vs 22.0 ? 1.6 cm/s, respectivelyin addition, anesthetized homozygotes show significantly increased transmitral blood velocities relative to wild type mice with peak mitral velocities at 92 ? 7.2 cm/s vs 47.2 ? 5.3 cm/s, and mean mitral velocities at 20.6 ? 1.7 vs 11.4 ? 1.3 cm/s, respectivelyno significant differences in heart rate, peak aortic acceleration or ejection time are observed in the conscious or anesthetized state, when normalized to body weighthowever, homozygotes show alterations in aortic arch acceleration suggestive of increased peripheral wave reflectionsincreased cardiac output (J:108154)under anesthesia, homozygotes exhibit elevated flow velocities suggesting elevated cardiac outputabnormal cardiac stroke volume (J:108154)under anesthesia, homozygotes appear to exhibit significantly increased stroke volumedecreased systemic vascular resistance (J:108154)under anesthesia, homozygotes appear to exhibit significantly reduced peripheral vascular resistance and compliance in the presence of normal blood pressuresabnormal blood-brain barrier function (J:69455)impairment of blood-brain barrier (BBB) functionimpairment of blood-nerve barrier (BNB) functiondecreased vasodilation (J:101576)homozygotes fed a normal or atherosclerotic diet show severely impaired endothelium-dependent relaxation to acetylcholine in aortic rings relative to age-matched C57BL/6J control micehomeostasis/metabolismabnormal circulating homocysteine level (J:73202)decreased plasma total homocysteine levelsdecreased circulating glucose level (J:73202)in plasmaabnormal circulating cholesterol level (J:73202)decreased HDL/total cholesterol ratiodecreased HDL/LDL ratioincreased circulating cholesterol level (J:73202, J:97385, J:101576)increasing with age (J:73202)exercise (15 or 60 min/day swim) causes no significant changes in total cholesterol levels among homozygotes or wild type mice relative to sedentary, genotype-matched controls (J:97385)on a normal diet, homozygotes display significantly increased plasma total cholesterol (TC) levels relative to C57BL/6J control mice (J:101576)on an atherosclerotic diet, homozygotes show a further significant increase in plasma TC levels relative to homozygotes on a normal diet (J:101576)increased circulating LDL cholesterol level (J:101576)on a normal diet, homozygotes display significantly increased plasma LDL cholesterol levels relative to C57BL/6J control miceon an atherosclerotic diet, homozygotes show a further significant increase in plasma LDL levels relative to homozygotes on a normal dietincreased circulating VLDL cholesterol level (J:101576)on a normal diet, homozygotes display significantly increased plasma VLDL cholesterol levels relative to C57BL/6J control miceon an atherosclerotic diet, homozygotes show a further significant increase in plasma VLDL cholesterol levels relative to homozygotes on a normal diethyperlipidemia (J:101576)homozygotes develop hyperlipidemia; however, HDL cholesterol levels, body weight and blood glucose remain unchanged relative to C57BL/6J control mice on a normal diet, with no further differences noted on an atheroscletoric dietincreased circulating triglyceride level (J:73202, J:101576)in plasma (J:73202)on a normal diet, homozygotes display significantly increased plasma triglyceride levels relative to C57BL/6J control mice (J:101576)on an atherosclerotic diet, homozygotes show a further significant increase in plasma triglyceride levels relative to homozygotes on a normal diet (J:101576)skin/coat/nailsskin lesions (J:73202)eruptive xanthomas on shoulder and back areas with lipids and extracellular matix as the predominant componentsgrowth/sizedecreased body weight (J:108154)at 13 months, homozygotes show a 22% reduction in body weight relative to wild type mice (34.5 ? 0.9 vs. 44.5 ? 1.1 g)hematopoietic systemdecreased hematocrit (J:108154)at 13 months, awake, unanesthetized homozygotes display slightly but significantly reduced hematocrits ( 11%) relative to wild type mice at 41.7 ? 1.1% vs 46.6 ? 0.4%; in contrast, systolic blood pressures remain unaffected (140 ? 7.6 mmHg vs 136 ? 7.4 mmHg)cellularoxidative stress (J:97385)regular exercise fails to reduce endogenous oxidant load and mitochondrial damage in hypercholesterolemic mutant micein contrast, regular exercise results in reduced mitochondrial damage and oxidant load and increased SOD2 and adenine nucleotide translocator activities in normocholesterolemic control micehearing/vestibular/earabnormal cochlea morphology (J:101576)endothelial nitric oxide synthase (eNOS) in mutant cochlea is distinctly reducedabnormal basilar membrane (J:101576)on an atherosclerotic diet, homozygotes display a sclerosed and atrophic basilar membraneorgan of Corti degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show significant degeneration of the organ of Corti in the basal turn while the middle turn is relatively normaldegeneration of the organ of Corti is excerbated by an atherosclerotic diet, with complete loss noted in the basal turn in some animalscochlear inner hair cell degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show almost complete loss of IHCs in the basal turn and some IHC loss in the middle turnIHC loss at the base turn is exacerbated by an atherosclerotic dietcochlear outer hair cell degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show almost complete loss of OHCs in the basal turn and some OHC loss in the middle turnOHC loss at the base turn is exacerbated by an atherosclerotic dietabnormal stria vascularis (J:101576)on an atherosclerotic diet, homozygotes display a sclerosed and atrophic stria vascularisabnormal tectorial membrane morphology (J:101576)on an atherosclerotic diet, homozygotes display a sclerosed and atrophic tectorial membranedecreased brainstem auditory evoked potential (J:101576)at 10 weeks, homozygotes fed a normal diet display higher ABR thresholds than C57BL/6J control mice at all test frequencies, with more hearing loss noted at 32 kHz; by 24 weeks, further hearing loss is detected at all test stimuli levelshomozygotes fed an atherosclerotic diet show higher ABR thresholds than homozygotes fed a normal dietdeafness (J:101576)homozygotes fed a normal diet display hearing loss esp. at high frequencies as compared with C57BL/6J control micea high positive correlation between ABR thresholds at 16 and 8 kHz, or click and atherosclerotic lesions, and atherosclerotic plaque area of the aorta, and plasma total choelsterol levels is observed in both normal diet and high-fat diet homozygotesnervous systemabnormal blood-brain barrier function (J:69455)impairment of blood-brain barrier (BBB) functionimpairment of blood-nerve barrier (BNB) functioncochlear inner hair cell degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show almost complete loss of IHCs in the basal turn and some IHC loss in the middle turnIHC loss at the base turn is exacerbated by an atherosclerotic dietcochlear outer hair cell degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show almost complete loss of OHCs in the basal turn and some OHC loss in the middle turnOHC loss at the base turn is exacerbated by an atherosclerotic dietcochlear ganglion degeneration (J:101576)at 24 weeks, homozygotes fed a normal diet show a reduced number of spiral ganglion cells in the basal turn of the cochlealoss of ganglion cells is excerbated by an atherosclerotic diet",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2006-04-25",null,0,0,null,null,"true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":3},"Michael","Hall","Michael.Hall@arc.wa.gov.au","N/A","N/A","No"]
[298,null,"129P1/ReJ-Lama2<dy>",null,"Recessive","laminin, alpha 2","Lama2","Unknown","mer, merosin, nmf417","MGI:99912","dystrophia muscularis","Lama2<dy>","MGI:1856026","10",{"$nulls":15},"No",{"$nulls":12},"This mutation arose spontaneously in the 129/Re inbred strain at The Jackson Laboratory in 1951. Homozygotes are deficient in merosin (J:18187). Partial restoration of the ability to express Lama2 can be achieved by transplantation of a primary muscle cell culture (J:32227). Lama2dy homozygotes are characterized by progressive weakness and paralysis beginning at about 3 1/2 weeks of age. The hindlimbs are affected first, later the axial and forelimb musculature. Death usually occurs before 6 months of age, and the mice are usually sterile (J:13125). Skeletal muscle shows degenerative changes with proliferation of sarcolemmal nuclei, increase in amount of interstitial tissue, and size variation among individual muscle fibers (J:13125). In the dorsal and ventral roots of the peripheral nerves, both spinal and cranial, Schwann cells fail to separate and ensheathe axons so that groups of closely apposed naked axons, normally seen only in early stages, persist into adulthood (J:5331). At birth there is a deficiency of Schwann cells in the spinal roots, but many undifferentiated cells are present which are probably uncommitted Schwann cells that can differentiate when transplanted to a normal environment (J:12727). In the rest of the peripheral nervous system, the basement membrane of Schwann cells is interrupted by gaps (J:5565), the internodal gap in the nodes of Ranvier is lengthened (J:5866, J:6188), and there is delayed onset of myelination with fewer myelinated axons and shorter internode length (J:12730). There is reduced conduction velocity in spinal roots and peripheral nerves (J:5948) and evidence of defective axonal transport in the sciatic nerve (J:5709, J:5906). It is probable that the myelination defects of the peripheral nerves are due to an intrinsic defect in the dystrophic Schwann cells but the evidence from transplantation experiments, chimeras, and cell cultures is somewhat conflicting (J:30709, J:5580, J:5904, J:7618). There is some evidence for defective myelination in the central nervous system also (J:7911). In culture, myogenic cells from homozygous Lama2dy mice develop muscle properties just as well as cells from control mice (J:5909) and there is no peripheral block of neuromuscular transmission (J:5851, J:5922). Muscle of Lama2dy homozygous mice transplanted into normal hosts is indistinguishable from transplanted control muscle by 100 days (J:8221). There is an extensive literature on morphological and biochemical defects in Lama2dy/Lama2dy muscle.",null,"129","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2006-05-03",null,0,0,null,null,"true",null,"Gary","Smith","La Trobe University","gary.smith@latrobe.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8772,"F9 human KI, mouse KO (195A)","C57BL/6-F9<tm1(F9)Csl>/195ACslApb",null,"Recessive","coagulation factor IX","F9","Nil","Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[326,"spasmodic","B6.C3Fe a/a-Glra1<spd>",null,"Recessive","glycine receptor, alpha 1 subunit","Glra1","Unknown","B230397M16Rik, nmf11, oscillator, ot","MGI:95747","spasmodic","Glra1<spd>","MGI:1856362","11",{"$nulls":15},"Yes",{"$nulls":12},"Impaired righting response:exhibit difficulty in regaining an upright posture when turned on their sides.response improved in mice receiving IP injections of aminooxyacetic acid, 15 micrograms/gm body weightLimb grasping:tend to clasp their hind feet when picked up by the tail and spunTremors: at rest, in a quiet cage, appear normal but are hyperexcitable and shake rapidly when disturbed.Exhibit a rapid tremor when picked up by the tail, however show no differences in the levels of the major CNS and PNS myelin proteins of lipidsAbnormal posture: stiff postureHyperactivity: mimics sublethal strychnine intoxicationAbnormal gait: walk slowly and on their toesMale infertility: males appear unable to breedImpaired acrosome reaction: the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-typeImpaired fertilization: in mutants, the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type",null,"C57BL/6 x C3HeB/Fe","Yes","Yes","Yes","Yes","No","Yes","Yes","Poor",{"$nulls":3},"No","2006-05-05",null,0,0,null,null,"false",null,"Peter","Schofield","Prince of Wales Medical Research Institute","p.schofield@unsw.edu.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[1729,"Grid2 Lc","B6.CBA-Grid2<Lc>/Wehi",null,"Semi-dominant","glutamate receptor, ionotropic, delta 2","Grid2","Unknown","B230104L07Rik, GluRdelta2, tpr","MGI:95813","lurcher","Grid2<Lc>","MGI:1857337","6",{"$nulls":15},"No",{"$nulls":12},"Neonatal lethality: mice are dead or dying within the first 12 hours after birth.Abnormal hindbrain morphology:* there is a general loss of neurons between E15.5 and birthAbnormal cerebellum development: conspicuous absence of Purkinje cells.Abnormal trigeminal motor nucleus morphology:* there is a conspicuous absence of large neurons* beginning at E15.5 large numbers of pyknotic cells are evident and an obvious increase in the number of pyknotic neurons in E16.5 mice is evident.* results in loss of muscle control required for suckling* abnormalities occur after its formation.","Reduced linear vestibular evoked potential:* elevated threshold and reduced amplitudesAtaxia: due to progressive loss of Purkinje cellsPurkinje cell degeneration: occurs within the first three weeks of life.","C57BL/6 x CBA","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-01",null,0,0,"WEHI","031","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7825,"MICki","C57BL/6-Gdf15<GDF15>/Ausb",null,"Recessive","growth differentiation factor 15","Gdf15",null,"macrophage inhibiting cytokine-1, MIC-1, NAG-1","MGI:1346047",{"$nulls":3},"8",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-01-04",null,0,0,"ABR - Moss Vale","3848","true",null,"Sam","Breit","Garvan Institute","breit@garvan.org.au",{"$nulls":6},"N/A","N/A","No"]
[1847,null,"B6By.Cg-Sd Mcoln3<Va-J> Krt25<Re>/JWehi",null,"Semi-dominant","mucolipin 3","Mcoln3","Unknown","6720490O21Rik, TRPML3, Va, varitint-waddler","MGI:1890500","mucolipin 3; varitint waddler Jackson","Mcoln3<Va-J>","MGI:1856231","3",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes are white with small patches of color and show severe behavioral abnormalities, poor postnatal viability and are nearly infertile.","Heterozygotes show normal/diluted/white hair patches, circling, hyperactivity, deafness, and reduced fertility.",null,"Yes","No","Yes","Yes","No","Yes","Yes","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,"WEHI","1269","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1956,"available from Animal Resources Centre - www.arc.wa.gov.au","129X1/SvJ",null,"Dominant",{"$nulls":37},"Inbred albino. Most other substrains carry the white-bellied agouti gene AW though only a subset have the agouti pattern as many carry albino or chinchilla and/or the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, P/J and FS/Ei).",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-09-04",null,0,0,"ARC",null,"true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":3},"WA",null,null,"N/A","N/A","No"]
[1965,"available from Animal Resources Centre - www.arc.wa.gov.au","DBA/2JArc",null,"Dominant","Inbred grey (Dilute Brown): a, Tyrp1<b>, Myo5a<d>, H-2<d>",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":15},"No",{"$nulls":12},"Poor breeding performance 0.5 young/female/wk., average litter 4.5. High incidence of sterility. Moderate life span (males and females 2 years). Moderate to high mammary tumour incidence in unfostered mice (70% in breeding females and 50% in virgin females). High incidence of spontaneous calcification of the heart muscle, up to 90% in older mice. Fairly docile, low blood pressure, high RBC count. Males susceptible to chloroform fumes.Susceptible to audiogenic seizures (begins at 2 weeks, peaks at 3 weeks, gradually declines with age). Recommended host for fibrosarcoma SaD2, lymphatic leukaemia P1534, mammary adenocarcinoma CaD2. Hybrids involving DBA/2 are often used as hosts of transplantable leukaemia L1210, melanoma S91 and MOPC myeloma. C5 deficient. This strain has been embryo rederived using enrofloxacin treated egg donor dams.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"Yes","2007-09-04",null,0,0,"ARC",null,"true",null,"Michael","Hall","Animal Resources Centre","Michael.Hall@arc.wa.gov.au",{"$nulls":6},"N/A","N/A","No"]
[3404,"ACT-mOVA-II","C57BL/6-Tg(CAG-OVA)916Jen",null,"Dominant",{"$nulls":25},"transgene insertion 916, Marc K Jenkins","chicken β-actin",{"$nulls":10},"Ubiquitously express membrane bound chicken ovalbumin under the control of chicken β-actin promoter.  Breed less well than hets",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13",null,0,0,"WEHI","099","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3410,"IL-6 KO","B6.129-Il6<tm1Kopf>/Wehi",null,"Recessive","interleukin 6","Il6","Nil","Il-6","MGI:96559","targeted mutation 1, Manfred Kopf","Il6<tm1Kopf>","MGI:1857197","5",{"$nulls":15},"No",{"$nulls":12},"Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-14","Cryopreserved sperm",40,0,"WEHI","112","true",null,"Warren","Alexander","Walter and Eliza Hall Institute of Medical Research","alexandw@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3520,"NOD.Idd11D","NOD.B6-Idd11<C57BL/6>/Wehi",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11; C57BL/6","Idd11<C57BL/6>","MGI:3036811","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes. It is best to best to begin monitoring development of glycosuria at weekly intervals starting at 10 wks of age.  Use of the strains generated defines the IDD region to between D4Mit72 ad D4Mit203",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2008-07-28",null,0,0,"WEHI","453","true",null,"Tom","Brodnicki","Walter and Eliza Hall Institute of Medical Research","brodnicki@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4464,"D/N","CBA-Tmc1<dn>/JAnuApb",null,"Recessive","transmembrane channel-like gene family 1","Tmc1","Unknown","dn , Beethoven, Bth","MGI:2151016","deafness","Tmc1<dn>","MGI:1856845","19",{"$nulls":15},"Yes",{"$nulls":12},"Mutant mice are characterized by progressive degeneration of the cochlear inner hair cells and concomitant deafness. Profound congenital deafness.",null,"CBA","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm",150,0,"ANU","126","true",null,"Bruce","Walmsley","The Australian National University","bruce.walmsley@anu.edu.au",{"$nulls":3},"Alistair","Reid","Alistair.Reid@anu.edu.au","N/A","N/A","No"]
[5035,"NDL2-5","FVB/N-Tg(MMTV-Erbb2*)NDL2-5Mul/JAusbApb",null,"Dominant",{"$nulls":25},"transgene insertion NDL2-5, William J Muller","mouse mammary tumor virus LTR",{"$nulls":11},"Females from several independent lines develop multiple mammary tumors that frequently metastasize to the lung. Tumor progression in these strains was associated with elevated levels of tyrosine-phosphorylated Neu and ErbB-3. ","FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",100,0,"Moss Vale",null,"true",null,"Leonie","Ashman","The University of Newcastle","leonie.ashman@newcastle.edu.au",{"$nulls":3},"Severine","Roselli","severine.roselli@newcastle.edu.au","N/A","N/A","No"]
[5041,"ICAM-1 null","B6.129S7-Icam1<tm1Bay>/JApb",null,"Recessive","intercellular adhesion molecule 1","Icam1","Normal","CD54, Icam-1, Ly-47, MALA-2, MGC:6195","MGI:96392","intercellular adhesion molecule 1; targeted mutation 1, Baylor College of Medicine","Icam1<tm1Bay>","MGI:1857183","9",{"$nulls":15},"No",{"$nulls":12},"Increased body weight: mice are ~20% heavier than wild-type or Sell<tm1Tft> mutant mice.Increased lymphocyte cell number: number of circulating lymphocytes is increased over wild-type (47% of wild-type number).Increased eosinophil cell number: increased significantly compared to wild-type (178% of wild-type).Increased neutrophil cell number: * 4-5 fold increase in numbers of circulating neutrophils. * number of circulating neutrophils is increased over wild-type (190% of wild-type number).Increased monocyte cell number: number of circulating monocytes is increased over wild-type (223% of wild-type number).Abnormal leukocyte migration: Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 64% after 4 hours.Abnormal cellular extravasation: 2 hours after thioglycollate-induced peritonitis, neutrophil entry into peritoneum is significantly inhibited by 61% compared to wild-type.Abnormal leukocyte rolling: * Tnfa (TNFalpha) treatment increases leukocyte rolling flux fraction slightly compared to wild-type. * rolling velocities of leukocytes are slightly greater compared to wild-type mice at times <30 minutes after surgery; >60 minutes after surgery-induced inflammation, rolling velocities are significantly faster than wild-type (58 vs 38 um/second). * similar results on rolling velocity are observed with Tnfa-activated rolling as induced by surgical trauma.Decreased susceptibility to endotoxin shock: * following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours. * mice only develop mild liver injury in response to low doses of LPS at 8 hours that does not worsen compared to wild-type mice that exhibit liver severe injury at 6 hours.Increased tumor growth/size: when injected with melanoma cells, mice exhibit a 2.6 fold increase in tumor volume on day 14 compared to wild-type mice.Decreased angiogenesis: in a disk angiogenesis assay, no increase in capillary density in response to Vegfa is observed in the dermal vasculature overlying implanted disks, whereas wild-type mice show a clear increase in capillary density in response to Vegfa.Abnormal cell physiology: endothelial cells show attenuated chemotactic response to Vegfa in transwell chemotactic assays compared with wild-type control cells.Abnormal cell migration.Abnormal nitric oxide homeostasis: in endothelial cell culture, Vegf-dependent and basal nitric oxide production is attenuated relative to wild-type cells.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",70,0,null,null,"true",null,"Rebecca","Robker","The University of Adelaide","rebecca.robker@adelaide.edu.au",{"$nulls":3},"Lisa","Akison","lisa.akison@adelaide.edu.au","M-107-2009","20060928-993","No"]
[6602,"BXD-32","BXD32/TyJArc",null,"Recessive",{"$nulls":37},"Normal","Normal","C57BL/6J x DBA/2","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"brother x sister","No","2011-10-04","Embryo",0,0,"ARC",null,"true",null,"Grant","Morahan","The Western Australian Institute for Medical Research","gem@waimr.uwa.edu.au","MRF Building Level 6 50 Murray St, Perth WA 6000 ",null,null,"Grant","Morahan","gem@waimr.uwa.edu.au","N/A","N/A","No"]
[7020,"CXCR5tg OT2; CXCR5tg OTII","B6;129-Il21r<tm1Wjl> Tg(Lck-Cxcr5)Cys Tg(TcraTcrb)425Cbn/JAusbApb",null,"Dominant","interleukin 21 receptor","Il21r","Nil","NILR","MGI:1890475","interleukin 21 receptor; targeted mutation 1, Warren J Leonard","Il21r<tm1Wjl>","MGI:2446509","7",{"$nulls":16},"transgene insertion 425, Frank Carbone",{"$nulls":11},"Homozygous mice are viable and fertile. In OTIItg mice there is a four-fold increase in the CD4 to CD8 peripheral T-cell ratio, and lymph node T-cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.T cells express T cell receptor specific for chicken ovalalbumin residues 323 - 339 in the context of H2-Ab1 (I-A<b>)Transgenic mice express the mouse alpha-chain and beta-chain T-cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. CXCR5tg mice express CXCR5 in naive T cells and in mature B cells. IL-21R knockout mice show a mild reduction in IgG1 isotype antibodies in response to infection or vaccination.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2012-07-17","Cryopreserved sperm",50,0,"Moss Vale",null,"true",null,"Cecile","King","Garvan Institute","c.king@garvan.org.au",{"$nulls":3},"Helen","McGuire","h.mcguire@garvan.org.au","09/15","1701/2005","No"]
[8363,"ASD867","BALB/cNCrlAnu:Yellow",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-04",null,0,869,"ANU","867","false",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":8},"No"]
[7775,"MyD88 knockout","B6.129P2(SJL)-Myd88<tm1.1Defr>/JMarpApb",null,"Recessive","myeloid differentiation primary response gene 88","Myd88","Nil",null,"MGI:108005","myeloid differentiation primary response gene 88; targeted mutation 1.1, Anthony L DeFranco","Myd88<tm1.1Defr>","MGI:4421295","9",{"$nulls":28},"Homozygous mice are viable and fertile. The Myd88-deficient allele encodes a deletion of exon 3 of the myeloid differentiation primary response gene 88 gene. MYD88 is a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. MyD88 signaling is required to limit bacterial burden and prolong survival during infection. Myd88-deficiency is associated with a number of immune system abnormalities, as well as hematopoietic system, molecular signaling, and apoptotic abnormalities. These mice have increased susceptibility to bacterial and viral infection and should be maintained in a specific pathogen free environment.","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","3",null,"homo x homo","No","2014-10-24","Cryopreserved sperm",80,0,"Monash",null,"true",null,"Mark","Hedger","Monash University","mark.hedger@monash.edu",{"$nulls":3},"Rosemary","Genovese","rosemary.genovese@mimr-phi.org","MMCB11/14","PC1-N31-11","No"]
[7787,"Dynll-SHH","C57BL/6-Dynll1<tm1.1Jhh> Shh<tm1(EGFP/Cre)Cjt>/StvApb",null,"Dominant","dynein light chain LC8-type 1","Dynll1","Normal","8kDa LC, DLC8, Dnclc1, Pin","MGI:1861457","dynein light chain LC8-type 1; targeted mutation 1.1, Jorg Heierhorst","Dynll1<tm1.1Jhh>",null,"5",{"$nulls":15},"Yes",{"$nulls":12},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"No","2014-11-17","Cryopreserved sperm",50,0,"St V",null,"false",null,"Jorg","Heierhorst","St Vincent's Institute","jheierhorst@svi.edu.au",{"$nulls":3},"Ashleigh","King","aking@svi.edu.au","019/13","069","No"]
[8780,"Tph2-GFP","CD1.FVB/N-Tg(Tph2-EGFP)LO210Gsat/Apb",null,"Dominant",{"$nulls":25},"transgene insertion LO210, GENSAT Project at Rockefeller University","Tph2",{"$nulls":10},"GFP expressed in Tph2-expressing cells. No other phenotype abnormalities. Breeding not great as Homs","GFP expressed in Tph2-expressing cells. No other phenotype abnormalities. prefer maintain line as hets for breeding.","Crl:CD1(ICR) ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-19","Cryopreserved sperm",50,0,null,null,"false",null,"Lincon","Stamp","University of Melbourne","lstamp@unimelb.edu.au",{"$nulls":8},"No"]
[7797,"Favola ; Cx40T202STg ; DeltaF","B6.CBA-Tg(Tie2-Gja5*T202S/EGFP)1/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, ","endothelial-specific receptor tyrosine kinase; Tie2, Tek",{"$nulls":11},"Expression of mutant form of Cx40 (Gja5) (amino acid substitution T202S at endothelial gap junctions.Body weight, blood pressure and heart rate are normal.Expression of transgene results in significant decrease in Cx37 expression.Endothelial Cx40T202S expression enhances myogenic activation and impairs endothelium-derived hyperpolarization (EDH) in mesenteric resistance arteries.Endothelial Cx40T202S expression increases stiffness of mesenteric resistance arteries. ","C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","8",null,null,"No","2014-11-25","Cryopreserved sperm",63,0,"ANU",null,"false",null,"Caryl","Hill","The Australian National University","caryl.hill@anu.edu.au",{"$nulls":3},"Klaus","Matthaei","klaus.matthaei@anu.edu.au","A2011/172","12.06","No"]
[7798,"DeltaG ; Cx40T152ATg","C57BL/6JAnu-Tg(Tie2-Gja5*T152A/EGFP)1/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 1, ","endothelial-specific receptor tyrosine kinase; Tie2, Tek",{"$nulls":12},"C57BL/6JAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","8",null,null,"No","2014-11-25","Cryopreserved sperm",48,0,"ANU",null,"false",null,"Caryl","Hill","The Australian National University","caryl.hill@anu.edu.au",{"$nulls":3},"Klaus","Matthaei","klaus.matthaei@anu.edu.au","A2011/172","12.06","No"]
[7804,"R26CreER RARaRARg R26eYFP","B6.Cg-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> RARa<tm1Ipc> RARg<tm1Ipc> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive",{"$nulls":37},"In absence of tamoxifen cells are wildtype, when treated with tamoxifen loss of the vitamin A receptors, RARa and RARg occur, causing different phenotypes in distinct cell types.","Unknown","C57BL/6","Yes","Unknown","Unknown","Yes","Unknown","Unknown","No","Excellent","At least 10",null,null,"No","2014-12-03","Cryopreserved sperm",50,0,"St V",null,"false",null,"Louise","Purton","St Vincent's Institute","lpurton@svi.edu.au",{"$nulls":3},"Louise","Purton","lpurton@svi.edu.au","025/11","243","No"]
[7810,"R26CreER RARaRARg R26eYFP","B6.Cg-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> RARa<tm1Ipc> RARg<tm1Ipc> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":58},"Louise","Purton","lpurton@svi.edu.au","025/11","243"]
[7263,"R26-CreERT2 Recql4fl/fl","B6.129-Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj> Recql4<tm2272Arte>/SviApb",null,"Dominant","RecQ protein-like 4","Recql4","Nil","RECQ4","MGI:1931028","RecQ protein-like 4; targeted mutation 1.1, TaconicArtemis","Recql4<tm1.1Arte>","MGI:5645319","15",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC044/10","IBC168"]
[7814,"SGSH Flox","C57Bl/6-Sgsh<tm1Ldru>/LdruApb","ldru","Recessive","N-sulfoglucosamine sulfohydrolase (sulfamidase)","Sgsh","Normal","4632406A19Rik, sulphamidase","MGI:1350341",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","0","6","brother X sister","No","2014-12-15","Cryopreserved sperm",50,0,null,null,"true",null,"Kim","Hemsley","South Australian Health and Medical Research Institute","kim.hemsley@sahmri.com",{"$nulls":3},"Kim","Hemsley","kim.hemsley@sahmri.com","990/10/17","005/2014","No"]
[8317,"CIB1 Transgenic ","C57BL/6-Tg(CAG-CIB1)/CcbApb",null,"Dominant",{"$nulls":25},"human Calcium and Integrin Binding Protein 1","Chicken Beta actin",{"$nulls":10},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-10-03","Cryopreserved sperm",50,0,null,null,"true",null,"Stuart","Pitson","Centre for Cancer Biology, University of South Australia","stuart.pitson@unisa.edu.au",{"$nulls":8},"No"]
[7784,"403, MHC-403","B6.129-Myh6<tm1Jse>/Apb",null,"Dominant","myosin, heavy polypeptide 6, cardiac muscle, alpha","Myh6","Unknown","A830009F23Rik, alpha cardiac MHC, alpha-MHC, alpha myosin, cardiomyopathy, hypertrophic 1, Myhca, Myhc-a","MGI:97255","myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jonathan G Seidman","Myh6<tm1Jse>","MGI:2182704","14",{"$nulls":28},"Lethal","Hypertrophy of myocytes with large hyperchromatic nuclei by 30 weeks of age, myocardial fiber disarray becoming marked by 30 weeks of age, moderate diffuse interstitial fibrosis by 30 weeks of age, starting as early as 15 weeks","C57BL/6","No","No","Yes","No","No","Yes","No","Good","9","15","Myh6tm1Jse/MYH6+ x MYH6/MYH6 ","No","2014-11-12","Cryopreserved sperm",70,0,null,null,"false",null,"Christopher","Semsarian","Centenary Institute","C.Semsarian@centenary.org.au","Locked Bag No. 6","Newtown","NSW","Tatiana","Tsoutsman","t.tsoutsman@centenary.org.au","Leonhard 2012-024","13-027","No"]
[7821,"ENU15NIH:085:Cd19-cre:Ikk2ca-Tg:G2","C57BL/6JAnu-Cd19<tm1(Cre)Cgn> Gt(ROSA)26Sor<tm4(Ikbkb)Rsky> Sppl2a<m1Anu>/AnuApb",null,"Recessive","CD19 antigen","Cd19",null,null,"MGI:88319","targeted mutation 1, University of Cologne","Cd19<tm1(Cre)Cgn>","MGI:1931143","7",{"$nulls":58},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A"]
[7821,"ENU15NIH:085:Cd19-cre:Ikk2ca-Tg:G2","C57BL/6JAnu-Cd19<tm1(Cre)Cgn> Gt(ROSA)26Sor<tm4(Ikbkb)Rsky> Sppl2a<m1Anu>/AnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Klaus Rajewsky","Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>","MGI:3687199","6",{"$nulls":58},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A"]
[8784,"R26-LSL-Adar1 Za","C57BL/6-Gt(ROSA)26Sor<tm5(Adar1Za)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",null,"Gt(ROSA)26Sor<tm5(Adar1Za)Cwa>",null,"6",{"$nulls":28},"normal (requires Cre to express Adar1 cDNA)","Normal (requires Cre to express Adar1 cDNA)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-04","Cryopreserved sperm",60,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[7830,"MH2-403","FVB-Tg(tetO7-hCMVmin-aMHCR403Q)1Rmgr/VccriApb",null,"Dominant",{"$nulls":25},"tetO7-hCMVmin-aMHCR403Q","tetO7-hCMVmin",{"$nulls":10},"Unknown","Normal","FVB/n","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Excellent","more than 10","N/A","FVB/n female x hemizygous MH2-403 male","No","2015-01-13","Cryopreserved sperm",70,0,"Victor Chang",null,"false",null,"Diane","Fatkin","Victor Chang Cardiac Research Institute","d.fatkin@victorchang.edu.au",{"$nulls":3},"Karen","Brennan","k.brennan@victorchang.edu.au","14/20","3026/2010","No"]
[7833,null,"C57BL/6-Klf5<flox>/Apb",null,"Dominant","Kruppel-like factor 5","Klf5",null,"4930520J07Rik, Bteb2, CKLF, IKLF","MGI:1338056",{"$nulls":3},"14",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,null,"No","2015-01-23","Cryopreserved sperm",80,0,null,null,"false",null,"Anna","Brown","University of South Australia","anna.brown2@unisa.edu.au",{"$nulls":3},"Anna ","Brown","anna.brown2@unisa.edu.au","30/10"," PC1 NLRD 14/2010","No"]
[7836,"Louise:TCR:Ly5a::N12","C57BL/6JSfdAnu-Tg(TLK2mHEL)2Ccg TCR:Ly5a::N12 /AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 2, Christopher C Goodnow","rat thyroglobulin","expression limited to thyroid","Ly5a",{"$nulls":7},"Unknown","Express low levels of membrane bound HEL in thyroid. Low serum levels of HEL detected.",null,"C57BL/6JStdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5","sib x sib","No","2015-01-25","Cryopreserved sperm",22,0,"ANU",null,"false",null,"Stephen","Daley","The Australian National University","stephen.daley@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7835,"Foxp3-gfp:kk:TCR:N12","B6.B10.BR-H2<k2> Foxp3<tm2Ayr> Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","forkhead box P3","Foxp3","Normal","JM2, scurfin","MGI:1891436","targeted mutation 2, Alexander Y Rudensky","Foxp3<tm2Ayr>","MGI:3574964","X",{"$nulls":15},"No","transgene insertion 1, Mark M Davis",null,null,"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","Histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Normal. Cells expressing FoxP3 fluoresce green, predominantly T cells.T cell express T cell receptor alpha and beta (Tcra and Tcrb, respectively) chains from the hen egg lysozyme (HEL)-specific T cell hybridoma 3A9",null,"129 x C57BL/6 x C57BL10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-01-25","Cryopreserved sperm",23,0,"ANU",null,"false",null,"Stephen","Daley","The Australian National University","stephen.daley@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8787,"hScl-CreER R26eYFP Srsf2P95H/+","B6-Srsf2<tm2874(P95H)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Tg(Tal1-cre/ERT)42-056Jrg/Apb",null,"Recessive","serine/arginine-rich splicing factor 2","Srsf2",null,"D11Wsu175e, MRF-1, SC35, Sfrs10, Sfrs2","MGI:98284",{"$nulls":3},"11",{"$nulls":16},"transgene insertion 42-056, Joachim R Gothert",{"$nulls":11},"\"normal\" - requires tamoxifen treatment to induce Srsf2 mutation to heterozygosity","\"normal\" - requires tamoxifen treatment to induce Srsf2 mutation to heterozygosity","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-06","Cryopreserved sperm",41,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[7842,"Foxo1-flox","B6.129-Foxo1<tm1Flv>/AnuApb",null,"Recessive","forkhead box O1","Foxo1","Normal","Afxh, FKHR, Fkhr1, Foxo1a","MGI:1890077","forkhead box O1; targeted mutation 1, Richard A Flavell","Foxo1<tm1Flv>","MGI:3840910","3",{"$nulls":28},"Normal",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-02-05","Cryopreserved sperm",22,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4713,"Rolex/C57","B6.129-Hccs<tm1Tcc>/MarpApb",null,"X-linked","holocytochrome c synthetase","Hccs","Unknown",null,"MGI:106911","targeted mutation 1, Timothy C Cox","Hccs<tm1Tcc>","MGI:3826866","X",{"$nulls":15},"Yes",{"$nulls":12},"NormalHomozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-04-08","Cryopreserved sperm",100,0,"Monash",null,"false",null,"Timothy","Cox","Monash University","timothy.cox@med.monash.edu.au",{"$nulls":3},"Timothy","Cox","timothy.cox@med.monash.edu.au","N/A","N/A","No"]
[7851,"ENU34:G1","ANU:ENU34:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-03-04","Cryopreserved sperm",1964,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Ayla","Lorenzo","apf.scientific.programs@anu.edu.au","A2014/61",null,"No"]
[7857,"Sppl2a:Ctss KO","C57BL/6JAnu-Sppl2a<m1Anu> Ctss<tm1Hap>/AnuApb","C57BL/6JAnu-Sppl2a<m1Anu> Ctss<tm1Hap>/AnuApb","Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802 ","signal peptide peptidase like 2A; mutation 1, The Australian National University","Sppl2a<m1Anu>","MGI:5432126","2","ENSMUSG00000027366","ENSMUST00000028844","2010106G01Rik-001",{"$nulls":7},"126746052","7",null,null,"ATTCATAGGATGCCATGTGGACAGTGCACGTACGTATCTGTTAGCCTATGATGCAATTAG",{"$nulls":13},"Unknown","Normal","C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-03-10","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[7313,"Epo-R-CreERT2 R26eYFP pRbfl/fl","C57BL/6-Epor<tm2285(Cre/ESR1)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Rb1<tm3Tyj>/SviApb",null,"Dominant","retinoblastoma 1","Rb1","Nil","pRb, Rb, Rb-1 ","MGI:97874","retinoblastoma 1; targeted mutation 3, Tyler Jacks ","Rb1<tm3Tyj>","MGI:2450162","14",{"$nulls":28},"Epo-R-CreER is lethal as a homozygous allele as it discrupts expression of endogenous Epo-R","none - tamoxifen inducible Cre knockin to Epo-R locus. ","C57BL/6","No","No","Yes","No","No","Yes","No","Excellent","on pure C57BL/6 - was derived on C57 ES line",null,"Epo-R-CreERT2 ki/+ to Epo-R-CreERT2+/+ (homozygous for all other alleles)","No","2013-04-10","Cryopreserved sperm",30,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC168 SABC025","No"]
[7313,"Epo-R-CreERT2 R26eYFP pRbfl/fl","C57BL/6-Epor<tm2285(Cre/ESR1)Arte> Gt(ROSA)26Sor<tm1(EYFP)Cos> Rb1<tm3Tyj>/SviApb",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor ","Unknown","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini ","Gt(ROSA)26Sor<tm1(EYFP)Cos>","MGI:2449038","6",{"$nulls":58},"Carl","Walkley","cwalkley@svi.edu.au","AEC040/10","IBC168 SABC025"]
[7860,"Rosa26-Cryab floxed knockin","B6;C-Gt(ROSA)26Sor<tm1(Cryab-FLAG)Kkha>/KkhaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Increased","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","Rosa26-Cryab-KI","Cryab-FLAG",null,"6",{"$nulls":28},"Floxed mice are viable and fertile","floxed mice are viable and fertile","C57BL/6 and Balb/C mixed background","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-03-18","Cryopreserved sperm",50,0,"UQ",null,"true",null,"Kum Kum","Khanna","QIMR Berghofer Medical Research Institute","KumKum.Khanna@qimrberghofer.edu.au",{"$nulls":3},"Amanda","Bain","Amanda.Bain@qimrberghofer.edu.au","A0707-606M","232/2002 NLRD","No"]
[1236,"Pinky ; ENU8C:027","B6JSfdAnu;CBA(Cg)-Zbtb16<pnky>/AnuApb","B6JSfdAnu;CBA(Cg)-Zbtb16<pnky>/AnuApb","Recessive","zinc finger and BTB domain containing 16","Zbtb16","Unknown","Green's luxoid, PLZF, Zfp145","MGI:103222","pinky","Zbtb16<pnky>","MGI:4462277","9","ENSMUSG00000066687","ENSMUST00000093852","Zbtb16-201","210","457","T to A","ENSMUSE00000584531","2","70","Tyrosine to STOP",{"$nulls":4},"ATCCTCTTCCACCGAAACAGCCAGCACTATACTCTAGACTTCCTCTCGCCAAAAACCTTCC","Yes",{"$nulls":12},"Limb deformity. Shortening and angular deformity of hindlimbs with extra digits present in some cases. Deformity affects mouse mobility.   Previously described homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.",null,"C57Bl6JSfdAnu x CBA/HAnu","Yes","No","Yes","Yes","No","Yes","Yes","Good","1 to B6JSfdAnu, 1x CBH/CaJ",null,null,"No","2007-06-15","Cryopreserved sperm",175,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anusha","Subramanium","anusha.subramanium@anu.edu.au","J.APF.13.08","N/A","No"]
[8790,"Slc1a5:Eif2ak4","C57BL/6NCrlAnu-Eif2ak4<m1Anu> Slc1a5<m1Anu>/AnuApb",null,"Recessive","eukaryotic translation initiation factor 2 alpha kinase 4","Eif2ak4","Unknown","GCN2","MGI:1353427",{"$nulls":3},"2",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-17","Cryopreserved sperm",22,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[7872,"Sppl2a KO2 conditional","B6.Cg-Sppl2a<tm1c(EUCOMM)Hmgu> Tg(ACTFLPe)9205Dym/2MarpAnuApb",null,"Recessive","signal peptide peptidase like 2A","Sppl2a","Unknown","2010106G01Rik, C130089K23Rik","MGI:1913802","signal peptide peptidase like 2A; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Sppl2a<tm1c(EUCOMM)Hmgu>","MGI:4887673","2",{"$nulls":16},"transgene insertion 9205, Susan Dymecki","ACTB, actin, beta, human","The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively",{"$nulls":9},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7879,"Spotty","STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/JAusb",null,"Dominant",{"$nulls":25},"transgene insertion 47, Elaine Fuchs","tetracycline-responsive promoter element (TRE) and cytomegalovirus regulatory elements (mCMV)",{"$nulls":10},"Normal","Normal","Mixed","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16",null,0,0,"ABR - Moss Vale","4111","true",null,"Pradeep","Tanwar","The University of Newcastle","Pradeep.Tanwar@newcastle.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7885,"C57BL/6-Nabp1-KO strain 2","STOCK Nabp1<tm1.1Kkha>/2KkhaApb",null,"Recessive","nucleic acid binding protein 1","Nabp1","Normal","Nbp1, Obfc2a, Ssb2","MGI:1923258","targeted mutation 1.1, Kum Kum Khanna","Nabp<tm1.1Kkha>",null,"1",{"$nulls":28},"Viable and Fertile","Viable and Fertile","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"homozygous x homozygous","No","2015-04-21",null,0,0,"QIMR",null,"true",null,"Kum Kum","Khanna","QIMR Berghofer Medical Research Institute","KumKum.Khanna@qimrberghofer.edu.au",{"$nulls":3},"Amanda","Bain","Amanda.Bain@qimrberghofer.edu.au","A0707-606M","232/2002 NLRD","Yes"]
[8794,"Tpbeta - Transgenic","C57BL/6-Tg(Tp beta)/Apb",null,"Dominant",{"$nulls":25},"Tb beta",{"$nulls":11},"Unknown","Unknown",null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-09-17","Cryopreserved sperm",50,0,null,null,"true",null,"Roshlien","Prakash","Kearns Facility","roshlien.prakash@health.nsw.gov.au",{"$nulls":8},"No"]
[7702,"Mot","B6.Cg-Rabl2a<mot>/MarpApb",null,"Recessive","RAB, member of RAS oncogene family-like 2A","Rabl2a",null,null,"MGI:1915958","RAB, member of RAS oncogene family-like 2; mot","Rabl2<mot>","MGI:5469381","15","ENSMUSG00000022621","ENSMUST00000023294","Rabl2a-201","218","311","A to G","ENSMUSE00000128937","5","73","Aspartic acid to Glycine",{"$nulls":4},"CACAGTAGACGGCAAGACGATCCTTGTGGACTTCTGGGATACAGCAGGCCAGGAGCGGTTC","Yes",{"$nulls":12},"Male InfertilityDecreased testis weightOligozoospermiaShort sperm flagellumAsthenozoospermia:• low total motility and minimal progressive motility• however, ultrastructure is normal",null,"C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Poor","15",null,null,"No","2014-06-13","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":3},"Jennifer","Lo","jennifer.lo@monash.edu","SOBSA/A/2009/96 ",null,"No"]
[4456,null,"B6;C-Gstz1<tm1Pgb>/AnuApb",null,"Recessive","glutathione transferase zeta 1 (maleylacetoacetate isomerase)","Gstz1","Nil","maleylacetoacetate isomerase","MGI:1341859","targeted mutation 1, Philip G Board","Gstz1<tm1Pgb>","MGI:3050206","12",{"$nulls":15},"No",{"$nulls":12},"Increased sensitivity to induced Morbidity/Mortality * 3% phenylalanine in the water is lethal to young homozygotes, less than 28 days old, but not to older homozygotes, greater than 66 days oldpremature death * several mutants died after 1 year of age from heart pathologiesDystrophic cardiac calcinosis* in some mutants over 1 year of age Calcification of the myocardium in the right atrium and/or ventricle is seen* calcification is also seen in 3 of 8 young mutants that died after 3% phenylalanine exposurecellular necrosis* in some mutants over 1 year of age myocyte necrosis is seen* myocyte necrosis is also seen in 2 of 8 young mutants that died after 3% phenylalanine exposureDecreased leukocyte cell number* 3% phenylalanine in the water results in decreased total white cell counts in mutants but not in wild-type micedecreased spleen weight * spleen weight is significantly decreased in female homozygotes and tends to be decreased in male homozygotes compared to wild-type mice* 3% phenylalanine in the water results in a dramatic decrease in spleen weight in homozygotes with reduction in both white and red pulp, but an increase in spleen weight in wild-type micechronic inflammation* in some mutants over 1 year of age chronic inflammation is seen in the heartliver inflammation* at 6 weeks and 6 months of age multifocal hepatitis is seenLiver inflammation* at 6 weeks and 6 months of age multifocal hepatitis is seenAbnormal hepatocyte morphology* large pleomorphic mitochondria are seen in hepatocytes from mutantsIncreased liver weight* on a normal diet liver weight is greater in homozygotes compared to wild-type miceHepatic necrosis* at 6 months of age 3 of 7 homozygotes show hepatocyte necrosis* 3 out of 8 homozygotes that died after 3% phenylalanine exposure displayed hepatocyte necrosisHepatic steatosis * 5 out of 8 homozygotes that died after 3% phenylalanine exposure displayed macrovesicular steatosis",null,"C57BL/6 x BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-20","Cryopreserved sperm",149,0,"ANU","148","false",null,"Philip","Board","The Australian National University","phillip.board@anu.edu.au",{"$nulls":3},"ASD",null,null,"N/A","N/A","No"]
[7622,"Shiraz KO ; SCN1B C121W","C57BL/6J-Scn1b<tm1.1Bion>/Apb",null,"Dominant","sodium channel, voltage-gated, type I, beta","Scn1b","Normal",null,"MGI:98247","sodium channel, voltage-gated, type I, beta; targeted mutation 1.1, Bionomics Limited","Scn1b<tm1.1Bion>","MGI:4829975","7",{"$nulls":28},"Seizures:• spontaneous and heat-inducedenvironmentally induced seizures.• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice• febrile seizures rapidly evolve into tonic-clonic seizures unlike in wild-type mice• mice exhibit febrile seizures at lower temperatures than wild-type miceTonic-clonic seizures:• febrile seizures rapidly evolve into tonic-clonic seizures unlike in wild-type miceAbnormal brain wave pattern.Postnatal growth retardation.Tremors: • severe","Environmentally induced seizures:• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice• mice exhibit febrile seizures at lower temperatures than wild-type miceAbnormal nervous system electrophysiology:• average burst duration in subicular pyramidal neurons is lengthened compared to in wild-type cells• neurons exhibit axonal hyperexcitability, increased spike gain, and increased burst firing compared with wild-type cells• however, total burst events and frequency of action potentials within bursts is normalAbnormal action potential:• the number of action potentials (APs) per bursts is increased compared to in wild-type mice• neurons begin firing APs at lower drive currents compared to in wild-type mice• the threshold for AP initiation is more negative than in wild-type cells• the amplitude of first APs is higher than in wild-type cells• the AP half-width is decreased compared to in wild-type cells• however, the frequency of action potentials within bursts is normal","C57BL/6J","Yes","No","Yes","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2014-03-24","Cryopreserved sperm",50,0,null,null,"false",null,"Steven","Petrou","The Florey","Steven.Petrou@brainsrus.org",{"$nulls":3},"Lynley","Cordeiro","lynley.cordeiro@florey.edu.au","010-090","2014_011","Yes"]
[5497,"PAF","C57BL/6-Ptafr<tm1Tksh>/Apb",null,"Recessive","platelet-activating factor receptor","Ptafr",null,"PAF receptor, PAFR","MGI:106066","platelet-activating factor receptor; targeted mutation 1, Takao Shimizu","Ptafr<tm1Tksh>","MGI:3036770","4",{"$nulls":15},"No",{"$nulls":12},"Normal.Increased susceptibility to type I hypersensitivity reaction: * homozygous mutants have a marked reduction in systemic anaphylactic symptoms when challenged with ovalbumin (OVA) * compared to controls, homozygous mice did not develop anaphylactic hypotension, anaphylactic tachycardia followed by bradycardia nor do they develop any anaphylaxis dependent changes in the lungs or suffer lethal affects in response to antigen challenge * homozygous mutants do respond normally to endotoxins and develop endotoixc shock at the same level as controls.Decreased inflammatory response: inflammatory response to S. venezuelensis worm infection is lower at 7 days after infection as indicated by lower numbers of eosinophils and globlet cells in tissue and diminished cytokine production, with a reduction in the production of Th2 cytokines (IL-4, IL-5, and IL-10) in the small intestine and by specific antigen-stimulated spleen or MLN cells.Increased susceptibility to parasitic infection: while the fecundity of the worm, Strongyloides venezuelensis, is decreased in mutant mice, overall elimination is delayed.",null,"C57BL/6","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",{"$nulls":3},"No","2011-05-04","Cryopreserved sperm",50,0,null,null,"false",null,"Christopher","O'Neill","The University of Sydney","chris.Oneill@sydney.edu.au",{"$nulls":3},"Giselle","Bellamy","gbellamy@nsccahs.health.nsw.gov.au","0905-004","N/A","No"]
[8796,"Casp1 KO","B6.Cg-Casp1<em1Vnce>/JAnuApb",null,"Recessive","caspase 1","Casp1","Nil","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544","caspase 1; endonuclease-mediated mutation 1, Russell Vance","Casp1<em1Vnce>","MGI:6246541","9",{"$nulls":31},"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-09-30",null,0,0,"ANU",null,"false",null,"Si Ming","Man","Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[7193,"CAG-Flpe","C57BL/6NTac-Tg(CAG-Flpe)2Arte/Ausb",null,"Dominant",{"$nulls":25},"transgene insertion 2, TaconicArtemis","chicken--actin promoter and an hCMV immediate early enhancer (CAG)",{"$nulls":10},"Ubiquitous expression of FLPe recombinase.","Ubiquitous expression of FLPe recombinase.","C57BL/6NTac","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2012-11-05",null,0,0,"ABR - Moss Vale","3157","true",null,"John","Mattick","Garvan Institute","j.mattick@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7892,null,"ENU24:045:unknown",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Incidental phenotype of lower CD44 MFI on CD4 T cells (inheritence unclear)",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-05-15","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","lisa.miosge@anu.edu.aua","N/A",null,"No"]
[7900,"L3mbtl1 KO","B6.129-L3mbtl1<tm1.1Haho>/Marp",null,"Recessive","l(3)mbt-like (Drosophila)","L3mbtl1","Nil","L3MBTL1","MGI:2676663","l(3)mbt-like (Drosophila); targeted mutation 1.1, Hanno Hock","L3mbtl1<tm1.1Haho>","MGI:4840260","2",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-05-27","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Harshal","Nandurkar","Monash University","harshal.nandurkar@monash.edu",{"$nulls":3},"Carly","Selan","carly.selan@monash.edu","N/A","N/A","No"]
[7901,"Cd19-cre","C57BL/6JAnu-Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","CD19 antigen","Cd19",null,null,"MGI:88319","targeted mutation 1, University of Cologne","Cd19<tm1(Cre)Cgn>","MGI:1931143","7",{"$nulls":29},"Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-06-01","Cryopreserved sperm",44,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8801,"ENU46:269:Stat2","C57BL/6NCrlAnu-Stat2<m1Anu>/AnuApb",null,"Recessive","signal transducer and activator of transcription 2","Stat2","Unknown","1600010G07Rik","MGI:103039",{"$nulls":3},"10",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-10-04","Cryopreserved sperm",47,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[7910,"CAG-rtTA3","B6(Cg).129-Tg(CAG-rtTA3)#Slowe/Anu",null,"Dominant",{"$nulls":25},"transgene insertion, Scott Lowe","cytomegalovirus (CMV) early enhancer element and chicken beta-actin",{"$nulls":11},"Ubiquitous expression of Cre recombinase","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","5",null,null,"No","2015-06-18","Cryopreserved sperm",54,0,"ANU","583","false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7918,"Mb1-cre","B6.C-Cd79a<tm1(cre)Reth>/Anu",null,"Dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a",null,"Cd79a, Iga, Igalpha, Ig alpha, Ig-alpha, Ly54, Ly-54, mb-1","MGI:101774","CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a<tm1(cre)Reth>","MGI:3687451","7",{"$nulls":29},"Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm",154,0,"ANU",null,"false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7919,"Ubf fl","STOCK Ubtf<tm1.1Moss>/Anu",null,"Recessive","upstream binding transcription factor, RNA polymerase I","Ubtf",null,"A930005G04Rik, Tcfubf, UBF, UBF1","MGI:98512","upstream binding transcription factor, RNA polymerase I; targeted mutation 1.1, Tom Moss","Ubtf<tm1.1Tmss>","MGI:5708602","11",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal",null,null,"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm",66,0,"ANU",null,"false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7925,"Il22-DY","C57BL/6NTac-Tg(Il22-DY)01Stsc/Anu",null,"Recessive","interleukin 22","Il22",null,"IL-22, Iltif, IL-TIF","MGI:1355307",{"$nulls":3},"10",{"$nulls":28},"Reporter for IL22 cytokine expression, no pathological phenotype",null,"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-06-19","Cryopreserved sperm",21,0,"ANU",null,"false",null,"Anne","Bruestle","The Australian National University","anne.Bruestle@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7927,"Mdm2<C305F>  S6<fl> Mx1-Cre","B6(Cg).129(Cg)-Mdm2<tm1.1Ypz> Rps6<tm1Gtho> Tg(Mx1-Cre)1Cgn/JAnu",null,"Recessive","ribosomal protein S6","Rps6","Normal","S6R","MGI:98159","ribosomal protein S6; targeted mutation 1, George Thomas","Rps6<tm1Gtho>","MGI:2387471","4",{"$nulls":61},"N/A","N/A"]
[7936,"ENU18:Recql4::B6","C57BL/6JAnu-Recql4<m2Anu>/AnuApb",null,"Recessive","RecQ protein-like 4","Recql4","Unknown",null,"MGI:1931028",{"$nulls":3},"15","ENSMUSG00000033762","ENSMUST00000036852","Recql4-201","1039","1122","G to A","ENSMUSE00000237138","5","347","Arginine to STOP",{"$nulls":4},"CAGCTTCCCTAGACAGAGGGAACTATATTCGACTCAACATGAAAAACAAACGCTTTGTACG","Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-06-26","Cryopreserved sperm",44,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"A2014/61",null,"No"]
[7932,"Ampd3 KO","C57BL/6N-Ampd3<tm1b(KOMP)Wtsi> Tg(CMV-cre)1Cgn/AnuApb",null,"Recessive","adenosine monophosphate deaminase 3","Ampd3",null,null,"MGI:1096344","adenosine monophosphate deaminase 3; targeted mutation 2a, Wellcome Trust Sanger Institute","Ampd3<tm1b(KOMP)Wtsi>",null,"7",{"$nulls":16},"transgene insertion 1, University of Cologne","Cytomegalovirus (CMV) early enhancer element and chicken beta-actin",{"$nulls":10},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2015-06-22",null,0,0,"ANU",null,"true",null,"Gaetan","Burgio","The Australian National University","Gaetan.burgio@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7942,"ENU33:G3","ANU:ENU33:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-07-02","Cryopreserved sperm",111,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":6},"A2014/61",null,"No"]
[8788,"R26-CreER Srsf2 P95H/+ Tet2fl/fl","B6-Srsf2<tm2874(P95H)Arte>  Tet2<tm1.1Iaai> Gt(ROSA)26Sor<tm1(EYFP)Cos>/Apb",null,"Recessive","serine/arginine-rich splicing factor 2","Srsf2",null,"D11Wsu175e, MRF-1, SC35, Sfrs10, Sfrs2","MGI:98284",{"$nulls":3},"11",{"$nulls":28},"normal - require tamoxifen treatment to induce Cre activity and gene modification","normal - require tamoxifen treatment to induce Cre activity and gene modification","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-06","Cryopreserved sperm",20,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[7948,"ENU35:G2","ANU:ENU35:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-07-23","Cryopreserved sperm",2996,30,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[7949,"ENU36:G1","ANU:ENU36:G1",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2015-07-23","Cryopreserved sperm",2648,22,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":6},"N/A",null,"No"]
[7895,"HOM.bm1.407","B6-H2-K<bm1> Tg(RIP1-Bcl2)407Wehi/J","WEHI","Dominant","histocompatibility 2, K region","H2-K","Unknown",null,"MGI:3040519","histocompatibility 2, K region; b haplotype mutation 1","H2-K<bm1>","MGI:3618114","17",{"$nulls":16},"human BCL2","rat insulin promoter","islet b cells",{"$nulls":9},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"Brother x sister and C57BL/6 x Positive","No","2015-05-18","Cryopreserved sperm",50,0,"St V",null,"false",null,"Helen","Thomas","St Vincent's Institute","hthomas@svi.edu.au",{"$nulls":3},"Stacey","Fynch","sfynch@svi.edu.au","020/14","249","Yes"]
[7954,"ENU30:078:Polr3b:B6","C57BL/6NCrlAnu-Polr3b<m2Anu>/AnuApb",null,"Recessive","polymerase (RNA) III (DNA directed) polypeptide B","Polr3b",null,"2700078H01Rik, A330032P03Rik, RPC2","MGI:1917678",{"$nulls":3},"10","ENSMUSG00000034453","ENSMUST00000077175","Polr3b-201","283","313","A to T","ENSMUSE00000292314","5","95","Arginine to STOP",{"$nulls":4},"CTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCATGAGTGCCGTCTGAG",{"$nulls":15},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-07-27","Cryopreserved sperm",55,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Lucy","Morris","lucy.morris@anu.edu.au","N/A",null,"No"]
[7959,"Ghrelin","B6.129-Ghrl<tm1> Mboat4<tm1>/Marp",null,"Dominant","ghrelin","Ghrl","Nil","2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP","MGI:1930008",{"$nulls":3},"6",{"$nulls":28},"Body weight, neuroprotection, blood glucose","unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"het x het","No","2015-08-05",null,0,0,null,null,"true",null,"Zane","Andrews","Monash University","zane.andrews@monash.edu",{"$nulls":3},"Zane","Andrews","zane.andrews@monash.edu","MARP 2012/042","PC1-N03-12","No"]
[7959,"Ghrelin","B6.129-Ghrl<tm1> Mboat4<tm1>/Marp",null,"Dominant","membrane bound O-acyltransferase domain containing 4","Mboat4","Nil","GOAT","MGI:2685017",{"$nulls":3},"8",{"$nulls":58},"Zane","Andrews","zane.andrews@monash.edu","MARP 2012/042","PC1-N03-12"]
[5537,"APN 75","C57BL/6N-Trim35<tm1(KOMP)Vlcg>/Marp",null,"Recessive","tripartite motif-containing 35 ","Trim35","Unknown","0710005M05Rik, A430106H13Rik, Hls5, Mair, mKIAA1098 ","MGI:1914104 ","tripartite motif-containing 35 ; targeted mutation 1, Velocigene","Trim35<tm1(KOMP)Vlcg>",null,"14",{"$nulls":15},"Yes",{"$nulls":12},"Unknown - Not bred to homozygocity ","Normal ","C57BL/6N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-07-14","Cryopreserved sperm",60,0,"Monash",null,"true",null,"The Australian","Phenomics Network","Monash University","leanne.cotton@monash.edu",null,"Clayton","Victoria","Leanne","Cotton","leanne.cotton@monash.edu","N/A","N/A","No"]
[7971,"Srsf7-flox","B6;129-Srsf7<tm1>/MarpApb",null,"Recessive","serine/arginine-rich splicing factor 7","Srsf7",null,"9430065L19Rik, 9G8, NX-96, Sfrs7","MGI:1926232",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-09-22",null,0,0,"Monash",null,"true",null,"Minna-Liisa","Anko","Monash University","minni.anko@monash.edu",{"$nulls":3},"Minna-Liisa ","Anko","minni.anko@monash.edu","MARP-2014-003-BC-Anko","PC2-N02-14","No"]
[7569,"ENU14Yaa:032:b:-Yaa:G5","B6(SB)-Lyn<m2Anu>/AnuApb","B6(SB)-Lyn<m2Anu>/AnuApb","Recessive","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog","Lyn",null,"Hck-2","MGI:96892","Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; mutation 1 Anu","Lyn<m2Anu>","MGI:5563397","4","ENSMUSG00000042228","ENSMUST00000041377","Lyn-001",{"$nulls":7},"3683632","9",null,null,"CTACATCATCACCGAGTTCATGGCTAAGGGTGAGTGGCATCACGAGTCTGTACCCCTAAA",{"$nulls":13},"Increased % immature B cells, and reduced % mature B cells (Almost no Mature B cells)",null,"C57BL/6JAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-01-17","Cryopreserved sperm",10,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7889,"alpha-syn X MPS IIIa Cg","B6.Cg;129X1-Sgsh<mps3a> Snca<tm1Rosl>/J",null,"Recessive","synuclein, alpha","Snca","Nil","alpha-Syn-; alpha-Synko;","MGI:1277151","targeted mutation 1, Arnon Rosenthal","Snca(tm1Rosl)","alpha-Syn-; alpha-Synko","6",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Yes","No","Good",null,null,"brother x sister","No","2015-05-11","Cryopreserved sperm",50,0,null,null,"true",null,"Kim","Hemsley","South Australian Health and Medical Research Institute","kim.hemsley@sahmri.com",{"$nulls":3},"Kim ","Hemsley","kim.hemsley@sahmri.com","978/4/2017","B141-PC1","No"]
[7415,"ENU25:040:MAST4:B6","C57BL/6NCrlAnu-Mast4<m1Anu>/AnuApb","C57BL/6NCrlAnu-Mast4<m1Anu>/AnuApb","Recessive","microtubule associated serine/threonine kinase family member 4","Mast4","Unknown","4930420O11Rik, mKIAA0303","MGI:1918885","microtubule associated serine/threonine kinase family member 4; mutation 1, The Australian National University","Mast4<m1Anu>","MGI:5563453","13","ENSMUSG00000034751","ENSMUST00000167058","Mast4-001","2176","2444","C to A","ENSMUSE00000483603","17","726","Glutamic acid to STOP",{"$nulls":4},"GATTAATGAGCATGACCACCAATCTCTATGAAGGCCACATAGAGAAGGACGCTCGAGAGTT",{"$nulls":13},"Malocclusion.Normal blood lymphocyte populations as measured by expression of following proteins: B220, CD3, C4, CD44, KLRG1, NK1.1, IgM, IgD by flow cytometry.",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",null,"G4",null,"No","2013-08-23","Cryopreserved sperm",45,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A",null,"No"]
[7735,"Duane ; ENU6NIHB:019","B6(Cg)-Tbx21<duane>/AnuApb","B6(Cg)-Tbx21<duane>/AnuApb","Recessive","T-box 21","Tbx21","Reduced","T-bet, Tblym, TBT1","MGI:1888984","T-box 21; Duane","Tbx21<duane>","MGI:4367995","11","ENSMUSG00000001444","ENSMUST00000001484","Tbx21-001",{"$nulls":7},"96962921","2",null,null,"CTGGTCGATACTTGACAATAAGGTTAACTGTCCACAGGGAACCGCTTATATGTCCACCCA","Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. Few circulating NK cells.Decreased NK cell number: the percent of NK cells in the blood, spleen, and liver is lower than in wild-type mice.Increased NK cell number:* the frequency of NK cells in the peripheral lymph nodes and bone marrow is increased compared to in wild-type mice.* NK cells accumulate in lymph nodes due to defective egression.Absent NK T cells: mice exhibit a near complete absence of invariant natural killer T cells unlike in wild-type mice.Abnormal NK cell differentiation:* NK cells exhibit an immature phenotype unlike in wild-type mice.* NK cells accumulate in lymph nodes due to defective egression.* in reconstitution experiments, derived NK cells accumulate in the peripheral lymph nodes due to defective egression.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","4","G5N4","Het x Het ; Hom x Hom","No","2014-09-06","Cryopreserved sperm",14,64,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A",null,"No"]
[7973,null,"RBC10","RBC10","Dominant","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Unknown","Microcytosis","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2015-09-24","Cryopreserved sperm",30,0,"ANU",null,"false",null,"Gaetan","Burgio","The Australian National University","gaetan.burgio@anu.edu.au",{"$nulls":6},"2014/55",null,"No"]
[7972,"Tau KO","B6.129X1-Mapt<tm1Hnd>/J ",null,"Dominant","microtubule-associated protein tau","Mapt","Nil","Mtapt, Tau","MGI:97180","microtubule-associated protein tau; targeted mutation 1, Hana N Dawson","Mapt<tm1Hnd>","MGI:2385630","11",{"$nulls":28},"Decreased susceptibility to pharmacologically induced seizures:• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type miceAbnormal axon extension:• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-typeAbnormal dendrite morphology:• between 4 and 7 days in culture, total dendritic length of mutant neurons is less than in wild-type; after 7 days in culture, neurons still lag behind wild-type showing more developmental delay.","Decreased susceptibility to pharmacologically induced seizures:• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent",{"$nulls":3},"Yes","2015-09-24",null,0,0,null,null,"true",null,"Christopher","Hovens","The University of Melbourne","chovens@unimelb.edu.au",{"$nulls":6},"1212596",null,"No"]
[7978,"C3 ; Fgf10 c.505_507del CRISPR","C57BL/6-Fgf10<em1>/Marp",null,"Recessive","fibroblast growth factor 10","Fgf10","Unknown","AEY17, FGF-10, Gsfaey17 ","MGI:1099809",{"$nulls":3},"13",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Good",{"$nulls":3},"No","2015-10-05","Cryopreserved sperm",40,0,"Monash",null,"true",null,"Warwick","Teague","Murdoch Childrens Research Institute","Warwick.Teague@rch.org.au",{"$nulls":3},"Leanne","Hawkey","leanne.hawkey@monash.edu","MARP/2012/105","PC1-N53/13","No"]
[7516,"PB-Tet","B6.FVB-Tg(Pbsn-rtTA*M2)42Xy/MarpApb","B6.FVB-Tg(Pbsn-rtTA*M2)42Xy/MarpApb","Dominant",{"$nulls":25},"transgene insertion 42, Xin Yuan","anterior prostate-specific rat promoter",{"$nulls":10},"Prostate specific rtTA expression; no other phenotype ","None/Unknown","C57BL/6J","No","Yes","Unknown","No","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2013-11-29","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Stuart","Ellem","Monash University","Stuart.Ellem@monash.edu",{"$nulls":6},"MARP/2011/070/BC","PC1-N61/09","No"]
[7988,"PTX3 knockout","B6.129-Ptx3<tm1Mant>",null,"Semi-dominant","pentraxin related gene","Ptx3",null,"pentraxin 3, TSG-14","MGI:104641","pentraxin related gene; targeted mutation 1, Alberto Mantovani","Ptx3<tm1Mant>","MGI:2675283","3",{"$nulls":28},"Reduced female fertility:\t• homozygotes display a severe defect in female fertilityLung inflammation:• lungs from Aspergillus fumigatus infected homozygotes display a massive inflammatory response, the presence of hyphae and numerous, mostly extracellular, conidia, relative to similarly infected wild-type controlsAbnormal T-helper 1 physiology:• upon challenge with Aspergillus fumigatus, homozygotes fail to develop an appropriate TH1-type response and display a cytokine profile skewed towards a TH2-type response, as revealed by reduced IFN-gamma and IL-12 levels and increased IL-4 levels in mutant lungsAbnormal macrophage physiology:• homozygotes exhibit defective recognition of Aspergillus fumigatus conidia by alveolar macrophagesImpaired macrophage phagocytosis:• in vitro, the ability of mutant alveolar macrophages to ingest and kill resting Aspergillus fumigatus conidia is impaired relative to wild-type macrophages","Normal.","C57BL/6","Yes","No","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-11-03","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Reading","The University of Melbourne","preading@unimelb.edu.au",{"$nulls":3},"Patrick","Reading","preading@unimelb.edu.au","1112311","2014/032","No"]
[7989,"Muc13 knockout","B6.129-Muc13<tm1>",null,"Dominant","mucin 13, epithelial transmembrane","Muc13","Nil","114/A10, Ly64","MGI:103190",{"$nulls":3},"16",{"$nulls":28},"No unchallenged phenotype and more severe intestinal inflammation and epithelial apoptosis under stress.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","12",null,"This strain can be maintained by het x het or hom x hom.","No","2015-11-04","Cryopreserved sperm",50,0,"UQ",null,"false",null,"Michael","McGuckin","Mater Research Institute - The University of Queensland","michael.mcguckin@mater.uq.edu.au",{"$nulls":3},"Hui","Tong","hui.tong@mater.uq.edu.au","MRI-UQ/288/12/UQ/BREED",null,"Yes"]
[8875,"Mal fl","C57BL/6-Mal<tm1Pjh>/PjhApb",null,"Recessive","myelin and lymphocyte protein, T cell differentiation protein","Mal","Normal","VIP17","MGI:892970",{"$nulls":3},"2",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-07","Cryopreserved sperm",50,0,null,null,"false",null,"Paul","Hertzog","Hudson Institute of Medical Research","paul.hertzog@hudson.org.au",{"$nulls":3},"Georgie","Wray-McCann","georgie.wray-mccann@hudson.org.au",null,null,"No"]
[6488,"p53 delta","B6.129S2-Trp53<tm1Tyj>/WehiAusbApb",null,"Semi-dominant","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11",{"$nulls":28},"Abnormal retinal vasculature morphology:*Background Sensitivity: abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes.*Abnormally dilated peripheral retinal blood vessels.Abnormal posterior eye segment morphology:*Background Sensitivity: on the C57BL/6J background aberrant ocular phenotypes are observed as early as 14 days of age.      Abnormal optic nerve morphology:        *Background Sensitivity: the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds.        Optic nerve degeneration:          *Background Sensitivity: degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background.        Optic nerve hypoplasia:          *Background Sensitivity: bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background.      Abnormal ocular fundus morphology:        *Background Sensitivity: pigmented or nonpigmented fibrous retrolental tissue is commonly found in homozygotes on the C57BL/6J background.        Abnormal retina morphology:        *Background Sensitivity: retinal folds are found in some homozygotes on the C57BL/6J background.          Abnormal retinal vasculature morphology:          *Background Sensitivity: abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes.          *Abnormally dilated peripheral retinal blood vessels.      Opacity of vitreous body:        *Background Sensitivity: fine snowflake-like vitreal opacities can be found on the C57BL/6J background by 21 days of age and may result from the accumulation of fibrous and vascular debris in the vitreous.Abnormal optic nerve morphology:*Background Sensitivity: the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds.      Optic nerve degeneration:        *Background Sensitivity: degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background.      Optic nerve hypoplasia:        *Background Sensitivity: bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13","Cryopreserved sperm",50,0,"Moss Vale","33","false",null,"Maija","Kohonen-Corish","Garvan Institute","m.corish@garvan.org.au",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[8003,"FcRn-","C.Cg-Fcgrt<tm1Dcr>/DcrJApb",null,"Dominant","Fc receptor, IgG, alpha chain transporter","Fcgrt","Nil","FcRn, neonatal Fc receptor","MGI:103017","Fc receptor, IgG, alpha chain transporter; targeted mutation 1, Derry C Roopenian","Fcgrt<tm1Dcr>","MGI:3511510","7",{"$nulls":28},"Decreased circulating serum albumin, decreased circulating IgG, decreased IgG halflife, increased albumin/IgG catabolism, impaired IgG-mediated cross presentation, impaired IgG transcytosis, deminished perinatal maternal IgG transport, ","Impaired","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",">9",null,"Normal","No","2015-12-08","Cryopreserved sperm",90,0,null,null,"false",null,"Kenneth","Beagley","Institute of Health and Biomedical Innovation","k2.beagley@qut.edu.au",{"$nulls":3},"Charles","Armitage","charles.armitage@qut.edu.au","1500000606","1100001476","No"]
[8002,"PEP-Delta 87\t\t\t\t\t","C57BL/6-Ptpn22<PEP-Delta87>MarpApb\t\t\t",null,"Recessive","protein tyrosine phosphatase, non-receptor type 22 (lymphoid)","Ptpn22","Unknown","70zpep, Ptpn8","MGI:107170",{"$nulls":3},"3",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Unknown","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-12-07","Cryopreserved sperm",50,0,null,null,"true",null,"Tony","Tiganis","Monash University","tony.tiganis@monash.edu",{"$nulls":3},"Tony","Tiganis","Tony.Tiganis@monash.edu","MARP/2012/066/BC","PC2-N05/14","No"]
[8013,"Aicda fl","C57BL/6N(Cg)-Aicda<tm1a(EUCOMM)Hmgu>/MarpAnuApb",null,"Recessive","activation-induced cytidine deaminase","Aicda","Normal","Aid","MGI:1342279","activation-induced cytidine deaminase; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Aicda<tm1a(EUCOMM)Hmgu>","MGI:4460367","6",{"$nulls":28},"Normal",null,"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"4",null,"No","2015-12-17","Cryopreserved sperm",80,0,"ANU","656","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Jonathon","Roco","jonathan.roco@anu.edu.au","N/A","N/A","No"]
[4746,"Rag:KK","B6.Cg-H2<k> Rag1<tm1Mom>/AnuApb",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17",{"$nulls":61},"N/A","N/A"]
[8020,"ICExiNOSxRKO/BL6","B6;129S2-Casp1<tm1Sesh> Ifngr1<tm1Agt> Nos2<tm1Mrl>/AnuApb",null,"Recessive","caspase 1","Casp1","Nil","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544","caspase 1; targeted mutation 1, Tara Seshadri","Casp1<tm1Sesh>","MGI:1927822","9",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown",null,"Hom X hom","No","2016-02-09","Cryopreserved sperm",43,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A","N/A","No"]
[8020,"ICExiNOSxRKO/BL6","B6;129S2-Casp1<tm1Sesh> Ifngr1<tm1Agt> Nos2<tm1Mrl>/AnuApb",null,"Recessive","interferon gamma receptor 1","Ifngr1",null,"CD119, Ifgr, IFN-gammaR, IFN-gamma R, Ifngr, Nktar","MGI:107655","interferon gamma receptor 1; targeted mutation 1, Michel Aguet","Ifngr1<tm1Agt>","MGI:1857286","10",{"$nulls":58},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A","N/A"]
[8023,"LysMcre","B6.129P2-Lyz2<tm1(cre)Ifo>/JAusbAnu",null,"Dominant","lysozyme 2","Lyz2","Normal","Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp","MGI:96897","lysozyme 2; targeted mutation 1, Irmgard Forster","Lyz2<tm1(cre)Ifo>","MGI:1934631","10",{"$nulls":28},"Unknown","Enlarged spleen:*Rare","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-02-16","Cryopreserved sperm",44,0,"ANU","668","false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[7653,"RBC12","C57BL/6-Dnm2<Rbc12>/WehiMarpApb",null,"Dominant","Dynamin 2","Dnm2","Reduced","Dyn2","MGI:109547",{"$nulls":3},"9",{"$nulls":28},"Lethal","Display microcytic anemia","C57BL/6","No","No","Yes","No","No","Yes","No","Good",null,"10","heterozygous intercrosses","No","2014-04-08",null,0,0,"Monash",null,"true",null,"Fiona","Brown","Monash University","fiona.brown2@monash.edu",{"$nulls":3},"Fiona","Brown","fiona.brown200@gmail.com","B/BL-2011/370IL","PC2-N17/11","No"]
[8029,"Ndst1 fl","B6.129-Ndst1<tm1Je>/UcsdAnu",null,"Recessive","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1","Ndst1","Normal","1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1","MGI:104719","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Jeffrey D Esko","Ndst1<tm1Je>","MGI:3589211","18",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",">10",null,null,"No","2016-03-24","Cryopreserved sperm",57,0,"ANU","677","false",null,"Chris","Parish","The Australian National University","david.simondavis@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8032,"CD11c-cre x Atg7","C57BL/6-Atg7<tm1Tchi> Tg(Itgax-cre)1-1Reiz/Wehi",null,"Recessive","autophagy related 7","Atg7","Normal","1810013K23Rik, Apg7l","MGI:1921494","autophagy related 7; targeted mutation 1, Tomaki Chiba","Atg7<tm1Tchi>","MGI:3587769","6",{"$nulls":16},"transgene insertion 1-1, Boris Reizis","mouse integrin alpha X (Cd11c)",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-03-31","Cryopreserved sperm",10,0,"WEHI",null,"true",null,"Justine","Mintern","The University of Melbourne","jmintern@unimelb.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8035,"B6Bst2","B6.129-Bst2<tm1Cln>/Wehi",null,"Recessive","bone marrow stromal cell antigen 2","Bst2",null,"2310015I10Rik, Bst-2, C87040, GREG","MGI:1916800",{"$nulls":3},"8",{"$nulls":30},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-04-04","Cryopreserved sperm",30,0,"WEHI",null,"true",null,"Justine","Mintern","The University of Melbourne","jmintern@unimelb.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8042,"gp130Y757F x sgp130Fc","B6.129- Il6st<tm1Ern> Tg(Hbb-sgp130Fc)/MarpApb",null,"Recessive","interleukin 6 signal transducer","Il6st","Unknown","CD130, D13Ertd699e, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst","Il6st<tm1Ern>","MGI:2388478","13",{"$nulls":15},"Yes","soluble gp130 fused to Fc portion of IgG1","beta globin",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,"heterozogous x homozygous","No","2016-04-13","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Brendan","Jenkins","Monash University","brendan.jenkins@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[5172,"Mir146 -/-","C57BL/6-Mir146<tm1.1Bal>/BalAnuApb",null,"Recessive","microRNA 146","Mir146","Nil","miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a","MGI:2676831","microRNA 146; targeted mutation 1.1, David Baltimore","MIr146<tm1.1Bal>","MGI:4882045","11",{"$nulls":28},"Premature death:• mice become moribund by 18 to 22 months of ageAbnormal lymphopoiesis:• at 6 months, mice develop lympho- and myeloproliferative syndrome compared with wild-type mice• however, mice exhibit normal lymphoid cell numbers at 6 to 8 weeks and disease is not present in mice treated with an IFNgamma blockerMyeloid hyperplasia:• at 6 months, mice develop lympho- and myeloproliferative syndrome compared with wild-type mice• however, mice exhibit normal myeloid cell numbers at 6 to 8 weeks and disease is not present in mice treated with an IFNgamma blocker• chronic myeloproliferation and myelofibrosis in the bone marrowExtramedullary hematopoiesis:• in the spleenAnemia:Abnormal bone marrow cell morphology/development:• by 18 to 22 months, mice develop end-stage fibrosis or a hypercellular bone marrow and pale bone marrow unlike wild-type miceIncreased bone marrow cell number:• by 18 to 22 monthsDecreased erythrocyte cell number:Decreased hematocrit:Decreased hemoglobin contentThrombocytopenia:Increased regulatory T cell number:• in the periphery but not thymus• not rescued by treatment with an IFNgamma blockerDecreased leukocyte cell number:Decreased lymphocyte cell numberDecreased monocyte cell numberEnlarged spleen:• progressive starting at 5 to 6 months of age• 6 to 7 times on necropsyIncreased spleen weightAbnormal regulatory T cell physiology:• increased proliferation and suppressive function (measured by Th1 cytokine production)Increased T cell derived lymphoma incidence:• some mice develop lymphomas of B cell or mixed T and B cell lineage in the cervical lymph node, gastrointestinal tract, liver and kidneyIncreased B cell derived lymphoma incidence:• some mice develop lymphomas of B cell or mixed T and B cell lineage in the cervical lymph node, gastrointestinal tract, liver and kidney• some mice develop high-grade diffuse large B cell lymphoma with apoptotic bodies and atypical mitosisIncreased follicular lymphoma incidence:• low-grade in some miceIncreased myeloid sarcoma incidence:• in the spleen and occasionally in the liver and kidney• myeloid tumors are transplantable into immunocompromised miceIncreased spleen neoplasm incidence:• spleen tumors with myeloid sarcoma histology in many miceMyelofibrosis:• myelofibrosis in the bone marrow",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-07-02","Cryopreserved sperm",93,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8043,"B6:Thy1.1","B6.Cg-Thy1<a>/AnuApb",null,"Recessive","thymus cell antigen 1, theta","Thy1",null,"CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2","MGI:98747","thymus cell antigen 1, theta; a variant","Thy1<a>","MGI:3579311","9",{"$nulls":28},"Normal",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-04-15","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[4988,"ATM 7271 T⇒G ; Adonis","C.B6-ATM<tm1Gct> ",null,"Recessive","ataxia telangiectasia mutated homolog (human)","Atm","Normal","C030026E19Rik","MGI:107202","targeted mutation 1, Georgia Chenevix-Trench","ATM<tm1Gct>",null,"9",{"$nulls":9},"Unknown to Unknown",{"$nulls":5},"No",{"$nulls":12},"Infertile. Increased sensitivity to ionizing radiation. Immune deficiencies. Increased susceptability to lymphoid tumours","Normal","BALB/c","Yes","No","Yes","Yes","No","Yes","Yes","Good","8",null,null,"No","2010-01-28","Cryopreserved sperm",163,0,"QIMR",null,"false",null,"Georgia","Chenevix-Trench","Queensland Institute of Medical Research","georgiaT@qimr.edu.au",{"$nulls":3},"Jeremy","Arnold","jeremyA@qimr.edu.au","N/A","N/A","No"]
[8049,"Slc6a19 fl","C57BL/6-Slc6a19<tm1Anu>/MarpAnu",null,"Recessive","solute carrier family 6 (neurotransmitter transporter), member 19","Slc6a19","Normal","4632401C08Rik, B<0>AT1","MGI:1921588",{"$nulls":3},"13",{"$nulls":28},"Normal",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-05-11","Cryopreserved sperm",94,0,"ANU",null,"true",null,"Stefan","Broer","The Australian National University","stefan.broer@anu.edu.au",{"$nulls":6},"N/A","N/A","Yes"]
[8065,"ENU32:085","ENU32:085",null,"Recessive",null,null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Abnormal population of B220+ CD4+ cells.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"5",null,"No","2016-07-05","Cryopreserved sperm",44,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","lisa.miosge@anu.edu.au","N/A",null,"Yes"]
[8058,"Mid1 Fxy","B6(Cg).129-Mid1<tm1Aash>/AnuApb",null,"X-linked","midline 1","Mid1","Nil","61B3-R, DXHXS1141, Fxy, Trim18","MGI:1100537","midline 1; targeted mutation 1, Alan Ashworth","Mid1<tm1Aash>","MGI:5562687","X",{"$nulls":28},"Viable. Reduced / delayed fertility. Litter size may be slightly reduced. No other phenotype described as yet.Abnormal axon morphology:• axon length and branch number are increased in cultured cortical neurons• callosal axons grow further into the contralateral hemisphere at P4• at P14, axon distribution in the corpus callosum is disturbed with a greater number of axon terminals, with a wider distribution in both the S1 and S2 regions• broader distribution of the contralateral axon projection pattern in the corpus callosumEmbryogenesis phenotype:• no obvious midline defects, unlike in Opitz Syndrome patients","Breeder pairs often only litter down after 3 months together, if they litter down at all. Around 1 in 3 produce litters.","C57BL/6NCrlAnu","Yes","Yes","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-06-22","Cryopreserved sperm",55,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","N/A","N/A","No"]
[8059,"BTBR","BTBR T<+> Itpr3<tf>/J",null,"Recessive","disrupted in schizophrenia 1","Disc1<del>","Nil","C1orf136; SCZD9","MGI:2447658","disrupted in schizophrenia 1; deletion","Disc1<del>","MGI:3623217","8",{"$nulls":28},"Abnormal allogrooming behaviour:number of bouts of social grooming, in which one member of the pair grooms the other, is less in 21 day old miceAbnormal locomotor activation:locomotion and exploratory activity in a novel open field is initially higher, but mice show normal activity levels after habituation.Abnormal social investigation:mice show reduced social approach, low reciprocal social interactions and impaired juvenile play.Abnormal vocalisation:pups show an usual pattern of calls, emitting high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls.Decreased anxiety-related response:percentage of time spent on the open segments of the elevated zero maze is higher, indicating very low anxiety-like traits.Excessive vocalization:pups call more loudly and more frequently when separated from their mothers and siblings.Impaired social transmission of food preference:mice eat less of the food familiarized by interacting with their demonstrator cage mate than of a completely unfamiliar foodmice sniff the whiskers and mouth of their demonstrator cage mate less frequently and for shorter periods of time.Increased grooming behaviour:both juvenile and adult mice exhibit high levels of repetitive self-grooming.Abnormal brain commissure morphology:Probst bundles are present on both sides of the midline in 100% of miceneocortices are not connected by the corpus callosum, through other forebrain commissures, nor via ectopic forebrain connections.no streamline connections between homologous interhemispheric areas via the anterior or hippocampal commissure are seen.Abnormal cerebral cortex morphology:changes in cortical thickness is not due to an increase in cell number of a specific cortical laminar population or due to increased apoptosisthickness of V1 cortical area is increased at P7 but not in adults.Abnormal neocortex morphology:V1 area of the neocortex is reducedlength of the cortex is reduced at P10, the width is reduced at P22the relative position of V1 and the posterior medial barrel subfield of the neocortex are shifted towards the midlinethe relative size of the posterior medial barrel subfield of the neocortex is reduced at P10 and the relative size of the visual area is reduced at P10 and P22the third barrel in row C (C3) of the posterior medial barrel subfield of the neocortex is located in a more medial relative position than in controlsAbsent corpus callosum:agenesis of the corpus callosumDecreased anterior commissure size:anterior commissure is reduced in size and volumeDecreased hippocampal commissure size:hippocampal commissure is greatly reduced in size and volume. Increased body weight:mice are heavier than C57BL/6 controls on P4, 6, 8, and 12Increased growth rate:mice show faster growth and development, having a fully developed righting reflex response by P2 compared to P6 in C57BL/6 controls, full negative geotaxis response acquired by P4 versus P8, earlier detachment of pinnae, opening of the eyes and incisor eruption, shorter latencies on the homing test suggesting more rapid development social olfactory and cognitive abilities, accelerated acquisition of various reflexes, and greater response to an acoustic stimulus on P12","Unknown","C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Excellent",null,null,"brother X sister","Yes","2016-06-24","Cryopreserved sperm",50,0,null,null,"true",null,"Kim","Hemsley","South Australian Health and Medical Research Institute","kim.hemsley@sahmri.com",{"$nulls":3},"Kim","Hemsley","kim.hemsley@sahmri.com","1004/6/18",null,"No"]
[8068,"Cx3cr1-cre","B6.129P2(Cg)-Cx3cr1<tm2.1(cre/ERT2)Litt>/WganJAnuApb",null,"Dominant","chemokine (C-X3-C motif) receptor 1","Cx3cr1","Unknown",null,"MGI:1333815","chemokine (C-X3-C motif) receptor 1; targeted mutation 2.1, Dan R Littman","Cx3cr1<tm2.1(cre/ERT2)Litt>","MGI:5450813","9",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-07-05","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Riccardo","Natoli","The Australian National University","Riccardo.natoli@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8071,"Ggt1-cre","STOCK Tg(Ggt1-cre)M3Egn/JAnuApb",null,"Dominant",{"$nulls":25},"transgene insertion M3, Eric G Neilson","rat proximal",{"$nulls":11},"Cre expression was limited to cortical tubular epithelium of the kidney, and was first detected around 7 days of age.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-07-06","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Stefan","Broer","The Australian National University","stefan.broer@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8078,"SJL Jax","B6(Cg).SJL-Ptprc<a>/JAnuApb",null,"Recessive",{"$nulls":37},"T cells express the Ptprc<a> allele instead of Ptprc<b> allele usually carried by Lymphocytes isolated from C57BL/6 mice.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8","1","a x a","No","2016-07-25","Cryopreserved sperm",55,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@phenomics.anu.edu.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A",null,"No"]
[8079,"SJL NCrl","B6(Cg).SJL-Ptprc<a>/NCrlAnuApb",null,"Recessive",{"$nulls":28},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1","T cells express the Ptprc<a> allele instead of Ptprc<b> allele usually carried by Lymphocytes isolated from C57BL/6 mice.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","9","2","a x a","No","2016-07-25","Cryopreserved sperm",87,0,"ANU","619","false",null,"The Australian","Phenomics Facility","The Australian National University","contact@phenomics.anu.edu.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A",null,"No"]
[8082,"ASD661:Pique:7","C57BL/6NCrlAnu-Zfr2<em1Anu>/AnuApb",null,"Recessive","zinc finger RNA binding protein 2","Zfr2","Unknown","2010013I23Rik, 9130206N08Rik","MGI:2143792",{"$nulls":3},"10",{"$nulls":28},"Unknown at this stage",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","Yes","Poor",{"$nulls":3},"No","2016-08-11","Cryopreserved sperm",11,0,"ANU","661","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Suzanne","Fowler","suzanne.fowler@anu.edu.au","A2015/25","13.10","No"]
[8088,"RHBDF1 KO","C57BL/6-Rhbdf1<em1Arl>/MarpApb",null,"Recessive","rhomboid 5 homolog 1","Rhbdf1","Unknown","Dist, Dist1, Egfr-rs","MGI:104328",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-08-24",null,0,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":6},"N/A",null,"No"]
[8089,"RHBDF1 KO","C57BL/6-Rhbdf1<em2Arl>/MarpApb",null,"Recessive","rhomboid 5 homolog 1","Rhbdf1",null,"Dist, Dist1, Egfr-rs","MGI:104328",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-08-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":6},"N/A",null,"No"]
[8097,"Cliff79B-A4","C57BL/6NCrlAnu-Cd79b<em2Anu>/AnuApb",null,"Recessive","CD79B antigen","Cd79b","Unknown","B29, Igb, Igbeta, Ig-beta","MGI:96431",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-07","Cryopreserved sperm",22,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Keisuke","Horikawa","keisuke.horikawa@anu.edu.au","N/A",null,"No"]
[8103,"Kca3.1","B6.129-Kcnn4<tm1Jemn>/Apb",null,"Recessive","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4","Kcnn4","Unknown","IK1, IKCa1, KCa3.1, mIKCa1, SK4","MGI:1277957","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, James E Melvin","Kcnn4<tm1Jemn>","MGI:3521668","7",{"$nulls":28},"Increased parotid gland size:• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seenAbnormal hematopoietic system physiology:• A23187-stimulated, clotrimazole sensitive uptake of 86Rb into red blood cells is nearly eliminated in homozygous mutants and A23187 has no effect on the tonicity at which 50% of mutant red cells lyseAbnormal T cell physiology:• shrinkage of T lymphocytes induced by the Ca2+ ionophore, ionomycin, is greatly reduced",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-15","Cryopreserved sperm",45,0,null,null,"false",null,"Giselle","Bellamy","The University of Sydney","giselle.bellamy@health.nsw.gov.au",{"$nulls":6},"N/A",null,"No"]
[8104,"Cliff79B-A2","C57BL/6NCrlAnu-Cd79b<em5Anu>/AnuApb",null,"Recessive","CD79B antigen","Cd79b","Unknown","B29, Igb, Igbeta, Ig-beta","MGI:96431",{"$nulls":3},"11",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-21","Cryopreserved sperm",11,0,"ANU",null,"false",null,"Keisuke","Horikawa","The Australian National University","keisuke.horikawa@anu.edu.au",{"$nulls":6},"N/A",null,"No"]
[8106,"T1germTg","Germline SIRT1 transgenics",null,"Dominant",{"$nulls":37},"Improved glucose tolerance,resistance to ageing, expected prolonged lifespan.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-09-21","Cryopreserved sperm",50,0,"ABR - Moss Vale",null,"false",null,"Giselle","Bellamy","The University of Sydney","giselle.bellamy@health.nsw.gov.au",{"$nulls":6},"N/A",null,"No"]
[8114,null,"ASD565:Hummels:F1#12:Mertk:Timd4",null,"Recessive","T cell immunoglobulin and mucin domain containing 4","Timd4",null,"B430010N18Rik, Tim4, TIM-4","MGI:2445125",{"$nulls":3},"11"]
[8119,null,"ASD565:Hummels:F1#12:Timd4",null,"Recessive","T cell immunoglobulin and mucin domain containing 4","Timd4",null,"B430010N18Rik, Tim4, TIM-4","MGI:2445125",{"$nulls":3},"11",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-10-26","Cryopreserved sperm",12,0,"ANU","565","true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8116,"ENU18:Olfr603:B6","C57BL/6NCrlAnu-Olfr603<m2Anu>/AnuApb",null,"Recessive","olfactory receptor 603","Olfr603","Unknown","GA_x6K02T2PBJ9-6092550-6092362, GA_x6K02T2PBJ9-6096387-6095449, MOR32-14_i, MOR32-2, Olfr604","MGI:3030437",{"$nulls":3},"7","ENSMUSG00000059874","ENSMUST00000071844.1","Olfr603-001",{"$nulls":25},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-10-26","Cryopreserved sperm",42,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8122,"ENU31:065","C57BL/6NCrlAnu-Eif2ak4<m1ANU>/AnuApb",null,"Recessive","eukaryotic translation initiation factor 2 alpha kinase 4","Eif2ak4","Unknown","GCN2","MGI:1353427",{"$nulls":3},"2",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-10-27","Cryopreserved sperm",48,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8117,null,"ASD565:Hummels:F1#12: MerTK",null,"Recessive","c-mer proto-oncogene tyrosine kinase","Mertk","Unknown","Eyk, Mer, nmf12, Nyk, Tyro 12","MGI:96965",{"$nulls":3},"2",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-10-26","Cryopreserved sperm",12,0,"ANU","565","true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8132,"WEHIG1:Fcho1:C57Crl","B6.Cg-Fcho1<m1Wehi>/Anuapb",null,"Recessive","FCH domain only 1","Fcho1","Unknown","3322402E17Rik","MGI:1921265",{"$nulls":3},"8",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-11-04","Cryopreserved sperm",33,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8136,"Ai32; ChR2(H134R)-EYFP","B6.129S6-Gt(ROSA)26Sor<tm32(CAG-COP4*H134R/EYFP)Hze>/JAusb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 32, Hongkui Zeng","Gt(ROSA)26Sor<tm32(CAG-COP4*H134R/EYFP)Hze>","MGI:5013789","6",{"$nulls":28},"No analysis performed",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-11-16","Cryopreserved sperm",88,0,null,null,"false",null,"Greg","Stuart","The Australian National University","greg.stuart@anu.edu.au",{"$nulls":8},"No"]
[8137,"Rosa26-FlagCep55 Tg","BALB/c-Gt(ROSA)26Sor<flag-Cep55>",null,"Dominant","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Increased","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","Flag-Cep55 Floxed",null,null,"6",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","5",null,null,"No","2016-11-16","Cryopreserved sperm",50,0,"QIMR",null,"false",null,"Amanda","Bain","QIMR Berghofer Medical Research Institute","Amanda.Bain@qimrberghofer.edu.au",{"$nulls":8},"No"]
[8159,"NODlga","NOD-Ifnlr1<em13Tcb> Ifngr1<em15Tcb> Ifnar1<em16Tcb>",null,"Recessive","Interferon gamma receptor 1","Ifngr1","Unknown","CD119, Ifgr, IFN-gammaR, IFN-gamma R, Ifngr, Nktar","MGI:107655",null,"em15Tcb",null,"10"]
[8143,"Alcam KO","B6.129(FVB)-Alcam<tm1Jawe>/JAnu",null,"Recessive","activated leukocyte cell adhesion molecule","Alcam","Nil","BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1","MGI:1313266","activated leukocyte cell adhesion molecule; targeted mutation 1, Joshua A Weiner","Alcam<tm1Jawe>","MGI:3056579","16",{"$nulls":28},"Abnormal retina morphology:\t• in 75% of mutant eyes retinal dysplasia is seen with finger like projections of photoreceptor cells protruding into the outer nuclear layer and/or invagination of the retina without disrupting the cell layers• dysplasia can be detected on P1Abnormal photoreceptor outer segment morphology:\t• photoreceptor outer segments appear elongated and disorganizedAbnormal retinal ganglion layer morphology:\t• axons are loosely bundled and occasionally have aberrant trajectories however all exit the optic disc normallyAbnormal motor neuron innervation pattern:\t• motor neurons are loosely bundled with some axons exiting the bundles at a right angle to the adjacent nerve and ending blindly or forming bridges to neighboring bundles",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-11-24","Cryopreserved sperm",44,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8154,"NODlga","NOD-Ifnlr1<em13Tcb>",null,"Recessive","Interferon lambda receptor 1","Ifnlr1","Unknown","CRF2-12, IFNLR1, Il28ra","MGI:2429859",null,"em13Tcb",null,"4",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-12-16","Cryopreserved sperm",70,0,"St V",null,"true",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":8},"No"]
[8151,"NODCrisprGzmA","NOD-Gzma<em3Tcb>",null,"Recessive","granzyme A","Gzma","Unknown","BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1","MGI:109266",null,"em3Tcb",null,"13",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2016-12-15","Cryopreserved sperm",50,0,"St V",null,"true",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":8},"No"]
[8160,null,"ENU36:080:Car2",null,"Recessive","carbonic anhydrase 2","Car2","Unknown","CAII, CA II, Car-2, Ltw-5, Lvtw-5","MGI:88269",{"$nulls":3},"3","ENSMUSG00000027562","ENSMUST00000029078.8","Car2-001","140","465","T to A","ENSMUSE00000371047","2","47","Leucine to Glutamine",{"$nulls":4},"TGCCCAGCATGACCCTGCCCTACAGCCTCTGCTCATATCTTATGATAAAGCTGCGTCCAAG",{"$nulls":13},"Red blood cells are resistent to lysis",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-12-22","Cryopreserved sperm",36,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":3},"Lisa","Miosge","lisa.miosge@anu.edu.au",null,null,"No"]
[8172,"Prox1enhCRISPR-Rafiki","C57BL/6-Prox1<em4Nlh>",null,"Recessive","prospero homeobox 1","Prox1","Unknown","A230003G05Rik","MGI:97772",{"$nulls":3},"1",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-01-23","Cryopreserved sperm",50,0,null,null,"true",null,"Natasha","Harvey","University of South Australia","Natasha.Harvey@unisa.edu.au",{"$nulls":8},"No"]
[8176,"ENU35:180:Nlrp3","C57BL/6NCrlAnu-Nlrp3<m1Anu>/Anu",null,"Recessive","NLR family, pyrin domain containing 3","Nlrp3","Unknown","Cias1, cryopyrin, Mmig1, NALP3, Pypaf1","MGI:2653833",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-03","Cryopreserved sperm",22,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":8},"No"]
[8178,"ENU37:055:Casp4","C57BL/6NCrlAnu-Casp4<m1Anu>/AnuApb",null,"Recessive","caspase 4, apoptosis-related cysteine peptidase","Casp4","Unknown","Casp11, Caspase-11, ich-3","MGI:107700",{"$nulls":3},"9",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-03","Cryopreserved sperm",36,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":8},"No"]
[7679,"ENU7PMH:130:B10:B6-ATkk:G9 ; Krusty:3A9:H2<k>","B6.Cg-H2<k> Ndfip1<kru> Tg(TcrHEL3A9)1Mmd/AnuApb",null,"Recessive","Nedd4 family interacting protein 1","Ndfip1","Unknown","0610010M22Rik","MGI:1929601","krusty","kru",null,"18","ENSMUSG00000024425","ENSMUST00000025293","Ndfip1-201",{"$nulls":7},"38612084","5",null,null,"TCTCTAATTAAGTGGATCCTTATTGTCAGGGTAAGTTGCATAGCAGAGAACAGATTGTGA",null,"transgene insertion 1, Mark M Davis","TCR",null,"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17","Spontaneous mast cell-rich dermatitis with median onset age 90 d, followed by weight loss and premature mortality at a median age of 160 d. This was accompanied by lymph- adenopathy, splenomegaly, increased CD86 and CD23 activation markers on B cells, expansion of the activated/memory subset of CD4<+> and CD8<+> T cells, greatly elevated serum IgE, and for- mation of a prominent population of IL-4<+> and IFN-γ<+> CD4<+>.Autonomous accumulation of CD4<+> effector cells not corrected by normal Foxp3<+> cells.Absence of Ndfip1 did not result in spontaneous activation of naïve CD4+ T cells. Naive Ndfip1<kru/kru> Tg(TcrHel3A9) CD4<+> transferred to congenic B10.BR CD45 mice injected with hen egg lysozyme. After 6 days continued to increase in frequency, a further 4 fold over d3 levels, whereas WT cells decreased 5 fold from d3 levels.",null,"C57BL/6JSfdAnu x B10.BR-H2<k2>","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2014-05-13","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Matthew","Cook","The Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Stephen","Daley","stephen.daley@anu.edu.au","N/A",null,"No"]
[8181,"Tap1/Tap2 KO ET26","C57BL/6J-Tap1/Tap2<em1Anu>/26MarpAnu",null,"Recessive","transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)","Tap2","Nil","Abcb3, Ham2, Ham-2, HAM2, MTP2, PSF2, Tap-2","MGI:98484",{"$nulls":3},"17"]
[8189,"ENU36:091:Rag2","C57BL/6NCrlAnu-Rag2<m1Anu>/AnuApb",null,"Recessive","recombination activating gene 2","Rag2","Unknown","Rag-2","MGI:97849",{"$nulls":3},"2","ENSMUSG00000032864","ENSMUST00000044031.3","Rag2-001","173","414","A to G","ENSMUSE00000230533","3","58","Lysine to Glutamic acid",{"$nulls":4},"TGATATAAAACAAAATCATCTCAAACTGAAGCCTGCAATCTTCTCTAAAGATTCCTGCTAC",{"$nulls":13},"FACS phenotype: Low B cells numbers in peripheral blood","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-02-16","Cryopreserved sperm",35,0,"ANU",null,"true",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":8},"No"]
[8187,"WEHIG1:Srgap1:C57Crl","B6.Cg-Srgap1<m1Wehi>/WehiAnuApb",null,"Recessive","SLIT-ROBO Rho GTPase activating protein 1","Srgap1","Unknown","4930572H05Rik, Arhgap13","MGI:2152936",{"$nulls":3},"10","ENSMUSG00000020121","ENSMUST00000081688.12","Srgap1-201","1994","2116","G to A","ENSMUSE00001215240","17","665","Proline to Leucine",{"$nulls":18},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-10","Cryopreserved sperm",48,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":8},"No"]
[8192,"Tg(Thy1-EGFP)MJrs/J x B6.Cg-Sgshmps3a/Ldru","B6.Cg-Sgsh<mps3a> Tg(Thy1-EGFP)MJrs/J",null,"Recessive","N-sulfoglucosamine sulfohydrolase (sulfamidase)","Sgsh",null,"4632406A19Rik, sulphamidase","MGI:1350341","Mucopolysaccharidosis IIIA","N-sulfoglucosamine sulfohydrolase (sulfamidase); mucopolysaccharidosis IIIA","Sgsh<mps3a>","11",{"$nulls":16},"transgene insertion M, Joshua R Sanes","Thy1, thymus cell antigen 1, theta, mouse, laboratory",{"$nulls":10},"These Thy1-GFP-M transgenic mice may be useful in neurobiological studies for fluorescent labeling of neural tissues, especially for mossy fibers in the cerebellum and intense, yet sparse, labeling of a variety of neuronal subsets. These mice carry a spontaneous mutation at the  Sgsh  locus characterized by scruffy coat, hunched posture, and reduced activity, and corneal opacity as a result of extensive lysosomal accumulation of heparin sulfate most prominently in neuronal tissue and liver and, to a lesser degree, in the spleen. ","These Thy1-GFP-M transgenic mice may be useful in neurobiological studies for fluorescent labeling of neural tissues, especially for mossy fibers in the cerebellum and intense, yet sparse, labeling of a variety of neuronal subsets. Mice that are heterozygous for the Sgsh gene appear normal but express 50% SGSH activity. ","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-17","Cryopreserved sperm",48,0,null,null,"true",null,"Kim","Hemsley","South Australian Health and Medical Research Institute","kim.hemsley@sahmri.com",{"$nulls":8},"No"]
[8194,"ASD552:Cahill:V203I","C57BL/6NCrlAnu-Ikbkb<em1Anu>/3AnuApb",null,"Recessive","inhibitor of kappaB kinase beta","Ikbkb","Unknown","IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta","MGI:1338071",{"$nulls":3},"8",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-02-20","Cryopreserved sperm",24,0,"ANU","552","true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au",null,null,"No"]
[8199,"B/c.BlGpA; B/c.TgN(HUFUT1-HUGTA-MUSMICAM2)","C.B6-Tg(Icam2-FUT1, GTA)",null,"Dominant",{"$nulls":25},"human H-transferase and human A-transferase","ICAM2",{"$nulls":10},"These mice are transgenic for two human genes encoding enzymes responsible for the synthesis of the blood group A antigen, which mice do not normally express. They express human blood group A on the surface of blood vessels throughout the body, and on erythrocytes and neutrophils. They develop and behave normally, and do not require special monitoring or care.","These mice are transgenic for two human genes encoding enzymes responsible for the synthesis of the blood group A antigen, which mice do not normally express. They express human blood group A on the surface of blood vessels throughout the body, and on erythrocytes and neutrophils. They develop and behave normally, and do not require special monitoring or care.","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","11",null,null,"No","2017-02-24","Cryopreserved sperm",50,0,"St V",null,"true",null,"Peter","Cowan","St Vincent's Hospital Melbourne","peter.cowan@svha.org.au",{"$nulls":8},"No"]
[8825,null,"ASD892:Rye:F0",null,"Recessive","GBP chrom5 C2 KO",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-11-12","Cryopreserved sperm",12,0,"ANU","892","true",null,"Gaetan","Burgio","Australian National University","gaetan.burgio@anu.edu.au",{"$nulls":8},"No"]
[8207,"Tap1/Tap2 KO x Tg(hTAP1/hTAP2) BAC #2","C57BL/6J-Tap1/Tap2<em1Anu> Tg(hTAP1/hTAP2)20/2MarpAnu",null,"Recessive","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","Tap1","Nil","Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1","MGI:98483",{"$nulls":3},"17",{"$nulls":16},"human transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / human transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)",{"$nulls":11},"Unknown","Unknown","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-02","Cryopreserved sperm",12,0,"ANU",null,"true",null,"David","Tscharke","The Australian National University","david.tscharke@anu.edu.au",{"$nulls":8},"No"]
[8206,"Tap1/Tap2 KO ET33","C57BL/6J-Tap1/Tap2<em1Anu>/33MarpAnu",null,"Recessive","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","Tap1","Nil","Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1","MGI:98483",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-02","Cryopreserved sperm",24,0,"ANU",null,"true",null,"David","Tscharke","The Australian National University","david.tscharke@anu.edu.au",{"$nulls":8},"No"]
[8216,"PV-Cre","B6.129-Pvalb<tm1(cre)Arbr/Anu",null,"Recessive","parvalbumin","Pvalb",null,"Parv, PV, Pva","MGI:97821","parvalbumin; targeted mutation 1, Silvia Arber","Pvalb<tm1(cre)Arbr>","MGI:3590684","15",{"$nulls":28},"Unknown",null,"C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-03-15",null,0,0,"ANU",null,"true",null,"Nathalie","Dehorter","The Australian National University","nathalie.dehorter@anu.edu.au",{"$nulls":8},"No"]
[8215,"R1584P KI ; Cav3.2 R1584P Knock-in","C57BL/6-Cacna1h<emR1584P>",null,"Dominant","calcium channel, voltage-dependent, T type, alpha 1H subunit","Cacna1h","Unknown","alpha13.2, Cav3.2, mKIAA1120, T-type Cav3.2","MGI:1928842",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Good",null,null,"Brother x Sister","No","2017-03-09","Cryopreserved sperm",50,0,null,null,"false",null,"Kim","Powell","The University of Melbourne","kpowell@unimelb.edu.au",{"$nulls":3},"Kim","Powell","kpowell@unimelb.edu.au",null,null,"No"]
[8218,"Roquin fl:Lck-cre","B6.Cg-Rc3h1<tm1.1Cgv> Tg(Lck-cre)157Jxm/AnuApb",null,"Recessive","RING CCCH (C3H) domains 1","Rc3h1","Unknown","5730557L09Rik, roquin","MGI:2685397","RING CCCH (C3H) domains 1; targeted mutation 1.1, Carola Vinuesa","Rc3h1<tm1.1Cgv>","MGI:5508920","1",{"$nulls":16},"targeted mutation I57, Jamey Marth; transgene insertion I57, Jamey Marth","mouse proximal Lck promoter","active in thymocytes and splenocytes",{"$nulls":10},"No phenotypic analysis","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"15",null,"No","2017-03-19","Cryopreserved sperm",84,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8219,"Sap KO:Ly5a","B6.Cg-Ptprc<a> Sh2d1a<tm1Pls>/AnuApb",null,"X-linked","SH2 domain protein 1A","Sh2d1a","Nil","Duncan disease homolog, SAP","MGI:1328352","targeted mutation 1, Pamela L Schwartzberg","Sh2d1a<tm1Pls>","MGI:2388241","X",{"$nulls":15},"No",{"$nulls":3},"protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","ptprc<a>","MGI:4819849","1","Decreased IgE level: * after immunization with ovalbumin, severe deficit in IgE is observed with little or no Ig E detected.Abnormal lymphocyte cell number:* although lymphocyte numbers were generally normal, occasional animals had increased T cell and NK cell numbers together with decreased B cell numbers in the spleen.Increased T cell proliferation:* tendency for T-cell proliferation to be increased even in the absence of infection.Abnormal T-helper 1 cell morphology:* biased toward the production of the Th1 cytokines Il-2 and IFN-gamma.Abnormal T-helper 2 cell morphology:* biased toward decreased production of the Th2 cytokine Il-4Decreased IgE level:* although levels of IgM, IgG, and IgA were normal, IgE levels were reduced.Increased susceptibility to infection.Increased susceptibility to parasitic infection:* elevated T-cell response to Toxoplasma gondii infectionlower titers of Ig isotypes directed against Toxoplasma antigensIncreased susceptibility to viral infection:* increased T-cell response to infection with lymphocyte choriomeningitis virus (LCMV).* Elevated activity of CD8+ cytotoxic T lymphocytes in spleenCD4+ cells also increased 2-3X.* decrease in antibody secreting cells in spleen and bone marrow.* more virulent strains led to increased morbidity.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-03-19","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8221,"ASDxxx:TCF-Lef_H2B-GFP","STOCK Tg(TCF/Lef1-HIST1H2BB/EGFP)61Hadj/J",null,"Dominant",{"$nulls":25},"transgene insertion 61, Anna-Katerina Hadjantonakis","T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) DNA binding site and a heat shock protein 1B (Hspa1b) minimal promoter",{"$nulls":10},"Mice homozygous for the transgene are viable, fertile, and normal in size.GFP expression is evident in cells of the extraembryonic visceral endoderm, the primitive streak, the mature node, presomitic mesoderm and newly formed somites, posterior neural plate, cranial neural crest, face, and branchial arches. By E12.5 fluorescence is also seen in the kidney, gonads, and some neuronal subsets in the brain.",null,"Unknown","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-20",null,0,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":8},"No"]
[8249,"ENU37:044","ENU37:044",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-04-28","Cryopreserved sperm",46,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8227,"CD28KO:H2G7","B6.NOD-Cd28<tm1Mak> H2<g7>/MarpAnu",null,"Recessive","CD28 antigen","Cd28",null,null,"MGI:88327","CD28 antigen; targeted mutation 1, Tak Mak","Cd28<tm1Mak>","MGI:1857150","1",{"$nulls":19},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; g7 variant","H2<g7>","MGI:3579321","17","CD28 KO mice:Increased T cell apoptosis:• after 96 hours in culture, only 68% of T cells are alive compared to 83% of controls• more mutant T cells are apoptotic after radiation dosage than in controlsAbnormal NK cell physiology:• alpha-galactosylceramide-induced cytotoxic activity of splenic and hepatic mononuclear cells was reduced compared to wild-type• alpha-galactosylceramide-induced anti-metastatic effect was substantially reduced compared to wild-type, indicating that natural killer cells are not able to fight off cancer cellsDecreased T cell proliferation:• T cells have markedly impaired proliferation in response to T cell co-stimulation (anti-CD3 + anti-CD28)Decreased circulating interferon-gamma level:• alpha-galactosylceramide-induced serum IFN-gamma levels were reduced compared to wild-typeDecreased circulating interleukin-4 level:• alpha-galactosylceramide-induced (an antigen that activates invariant natural killer T cells) serum IL-4 levels were reduced compared to wild-typeIncreased susceptibility to type I hypersensitivity reaction:• mice have reduced airway hyperresponsiveness after sensitization and challenge with OVADecreased interleukin-2 secretion:• T cells secrete less IL-2 when activated compared to controlsDecreased susceptibility to experimental autoimmune encephalomyelitis:• mice fail to develop EAE after immunization with MOG and even lack inflammatory infiltrates into the spinal cord","H2G7 mice are resistant to type 1 diabetes","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-28","Cryopreserved sperm",34,0,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[8237,null,"NOD-Gzma<em3Tcb> Tmem173<em1Tcb>",null,"Recessive","Transmembrane protein 173","Tmem173","Unknown","2610307O08Rik, ERIS, MPYS, Sting","MGI:1919762",{"$nulls":3},"18",{"$nulls":28},"Unknown","Unknown","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-03-31","Cryopreserved sperm",50,0,"St V",null,"true",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":8},"No"]
[8242,"Cntnap2 KO","B6.129(Cg)-Cntnap2<tm1Pele>/JAnu",null,"Recessive","contactin associated protein-like 2","Cntnap2","Nil","5430425M22Rik, Caspr2, mKIAA0868","MGI:1914047","contactin associated protein-like 2; targeted mutation 1, Elior Peles","Cntnap2<tm1Pele>","MGI:2677631","6",{"$nulls":28},"Seizures:• mutants older than 6 months of age commonly exhibit spontaneous seizuresEnvironmentally induced seizures:• seizures are induced by mild stressors during routine handlingAbnormal brain interneuron morphology:• mutants exhibit a reduction in parvalbumin+ interneurons in the hippocampus• mutants exhibit a decrease in the number of GABAergic interneurons in all laminae and in the striatumAbnormal corpus callosum morphology:• ectopic neurons are seen in the corpus callosum of mutants at P14; ectopic neurons are seen through adulthoodAstrocytosis:• reactive astrocytosis is seen throughout the hippocampus after onset of seizures, especially in the hilus• however, neuronal loss is not seen in the hippocampusAbnormal brain wave pattern:• at 8 months of age, freely moving mutants exhibit generalized interictal spike discharges during slow-wave sleepAbnormal neuron physiology:• mutants exhibit reduced cortical neuronal synchrony as indicated by two-photon calcium imaging of layer II/III neurons from somatosensory cortex showing that neuronal firing pattern is highly asynchronous compared to wild-type mice• however, neither the average firing amplitude nor the average firing rate are changed, suggesting that the defect is due to a network dysfunction rather than abnormalities in neuronal activity or conduction per seAbnormal neuronal migration:• ectopic neurons are seen in the corpus callosum of mutants at P14• mutants exhibit abnormal migration of cortical projection neurons as evidenced by the higher numbers of CUX1+ cells in deep cortical layersAbnormal olfaction:• mutants perform better than wild-type mice in the buried food test, indicating better olfactionBehavior/neurological phenotype:N\t• no differences are seen in the light-dark exploration test between mutants and wild-type mice• mutants treated with the drug Risperidone exhibit rescue of the hyperactivity, repetitive behavior/perseveration and nesting deficitsAbnormal inhibitory learning:• mutants perform similarly to wild-type mice in the Morris water maze probe trials, however in a classic reversal task using the Morris water maze, mutants show impaired learning of the new location of the platform and perform poorly in the probe testIncreased grooming behavior:• mutants spend almost 3 times more time grooming than wild-type miceAbnormal motor coordination/ balance:• mutants perform better than wild-type mice on the rotorodHyperactivity:• mutants show greater locomotor activity than wild-type mice in the open field test• mutants treated with the drug Risperidone exhibit rescue of the hyperactivityIncreased stereotypic behaviour:• in the spontaneous alternation T maze test, mutants show higher number of no alternations in a standard 10 trial test, indicating preservation• mutants treated with the drug Risperidone exhibit rescue of the repetitive behavior/perseverationDecreased thermal nociceptive threshold:• mutants exhibit hyperreactivity to thermal sensory stimuli• however, no differences seen in the acoustic startle response or prepulse inhibitionAbnormal nest building behaviour:• mutants are impaired in nest-building behavior, scoring less than half of the wild-type criterion• mutants treated with the drug Risperidone exhibit rescue of the nesting deficitsSocial withdrawal:• in a juvenile play test, mutants at P21 spend less time interacting with each other and instead show increased repetitive behaviors such as grooming and digging• in a three-chamber social interaction test in adults, mutants do not show a preference for the cup with a mouse as seen in wild-type miceDecreased vocalization:• mutants emit a lower number of ultrasonic calls than wild-type mice at all ages",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-31",null,0,50,"ANU",null,"false",null,"Nathalie","Dehorter","The Australian National University","nathalie.dehorter@anu.edu.au",{"$nulls":8},"No"]
[8241,"TgDNPKR","C57BL/6-Tg(Vav1-EIF2AK2*K296R)1Wsmay/JAnu",null,"Dominant",{"$nulls":25},"transgene insertion 1, W May","mouse vav 1 oncogene",{"$nulls":10},"Mice express a catalytically-null/dominant-negative (K296R) mutant variant of human PKR (DNPKR) exclusively in hematopoietic cells/tissues under control of the mouse HS21/45-vav regulatory elements.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-03-31","Cryopreserved sperm",55,0,"ANU",null,"true",null,"Si Ming","Man","The Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[8236,"IFNAR-/- IFNGR-/- ADAR1 E861A/+","B6-Ifnar1<tm1Agt> Ifngr1<tm1Agt> Adar<tm1.1Xen>",null,"Recessive","interferon (alpha and beta) receptor 1","Ifnar1","Nil","Ifar, IFN-alpha/betaR, Ifrc ","MGI:107658","interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet","Ifnar1<tm1Agt>","MGI:1930950","16",{"$nulls":28},"Homozygous triple nulls are not viable (embryonic lethal - time point not determined yet).","Viable, fertile and apparently normal","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2017-03-31","Cryopreserved sperm",50,0,"St V",null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au","Stem Cell Regulation Laboratory St. Vincent's Institute 9 Princes St","Fitzroy ","VIC","Carl","Walkley","cwalkley@svi.edu.au","032/11","233/234","No"]
[8254,null,"ASD733:Forge:::F0",null,"Recessive","RING CCCH (C3H) domains 1","Rc3h1",null,"5730557L09Rik, roquin","MGI:2685397",{"$nulls":3},"1",{"$nulls":28},"Unknown","TBA","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-05-12","Cryopreserved sperm",11,0,"ANU",null,"true",null,"Vicki","Athanasopoulos","The Australian National University","vicki.athanasopoulos@anu.edu.au",{"$nulls":3},"Lucy","Morris","lucy.Morris@anu.edu.au",null,null,"No"]
[8832,"Csf2rb fl/fl","C57BL/6N-Csf2rb<tm1c(EUCOMM)Hmgc>",null,"Recessive","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb",null,"AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Csf2rb<tm1c(EUCOMM)Hmgu>","MGI:5792881","15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-12-04","Cryopreserved sperm",50,0,null,null,"false",null,"John","Hamilton","University of Melbourne","jahami@unimelb.edu.au",{"$nulls":8},"No"]
[8259,"PbT-II","C57BL/6-Tg(Tcra,TcrbPbA)1Cbn",null,"Dominant",{"$nulls":25},"T cell receptor alpha, T cell receptor beta",{"$nulls":11},"Expression of a TCR specific for the malaria parasite Plasmodium",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-05-24","Cryopreserved sperm",14,0,"ANU",null,"false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":8},"No"]
[8258,null,"ASD696:Thunderbird:1del::F2",null,"Recessive",{"$nulls":37},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-05-22","Cryopreserved sperm",24,0,"ANU","696","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8061,"Thy1-YFP","B6.Cg-Tg(Thy1-YFP)HJrs/JApb",null,"Dominant",{"$nulls":25},"transgene insertion H, Joshua R Sanes","Thy1, thymus cell antigen 1, theta, mouse, laboratory",{"$nulls":10},"Unknown","These thy1-YFP-H transgenic mice express yellow fluorescent protein at high levels in motor and sensory neurons, as well as subsets of central neurons. Axons are brightly fluorescent all the way to the terminals. This line provides a strong and specific \"Golgi-like\" vital marker for several widely studied neuronal subsets, with minimal labeling of nearby axons. ","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-06-30","Cryopreserved sperm",50,0,null,null,"true",null,"Kim","Hemsley","South Australian Health and Medical Research Institute","kim.hemsley@sahmri.com",{"$nulls":6},"N/A","N/A","No"]
[4796,"NODLt","NOD/Lt",null,"Dominant",{"$nulls":37},"Predisposed to diabetes",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06","Cryopreserved sperm",150,0,"ANU","131","false",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au","Building 117, Garran Road","Acton","ACT",{"$nulls":3},"A.BS.01.09","N/A","No"]
[4466,"B10.PD1","C57BL/10-Tg(PD1)/AnuApb",null,"Dominant",{"$nulls":25},"porcine class I major histocompatibility complex (SLA) gene",{"$nulls":11},"This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.",null,"C57BL/10","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-22","Cryopreserved sperm",150,0,"ANU","136","false",null,"Charmaine","Simeonovic","The Australian National University","charmaine.simoeonovic@anu.edu.au",{"$nulls":3},"Alistair ","Reid","Alistair.Reid@anu.edu.au","N/A","N/A","No"]
[4088,null,"KRN:001",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Hypo response post arthritogenic serum transfer. Candidate gene position likely to be Chr 6 or 14.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm",30,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[8271,"nZegEGFP:Hamlet","C57BL/6JSfdAnu-Tg(IghelMD4)4Ccg Tg(/AnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"low copy number",{"$nulls":9},"Bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background. Transgenic mice, more than 90% of B-cells in the spleen are derived from the transgene (a allotype) and are predominantly IgM and IgD. There is a moderate reduction in B cell frequency and number in spleen and lymph node. B cells did not express Ly-1 or Mac-1. The Ig phenotype of splenic B cells in adult mice (IgMhiIgDlo-hi) resembled that of splenic B cells in non-transgenic 1 - 2-week-old mice.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"17",null,"No","2017-07-05","Cryopreserved sperm",22,0,"ANU",null,"false",null,"David","Simon Davis","The Australian National University","David.SimonDavis@anu.edu.au",{"$nulls":8},"No"]
[4096,null,"KRN:123",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"Hypo response post arthritogenic serum transfer. Candidate gene position likely to be Chr 5 or 11.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"2",null,"No","2008-12-04","Cryopreserved sperm",45,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[4097,null,"KRN:026",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model. Candidate gene position likely to be Chr 1 or 5.",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",null,"3",null,"No","2008-12-04","Cryopreserved sperm",15,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[4106,null,"KRN:037",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":15},"Yes","transgene insertion KRN, Diane Mathis","Natural TCR alpha and -beta promoter/enhancer elements.",{"$nulls":10},"No arthritis in KRN/H2g7 model",null,"C57BL/6 x NODk x C57BL/10 x Balb/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-05","Cryopreserved sperm",10,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[8266,null,"ENU37:009",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Homozygous mice have increased immature B cells in the blood and absence of marginal zone B cells in the spleen.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-06-07","Cryopreserved sperm",24,0,"ANU",null,"false",null,"Chris","Goodnow","The Australian National University","chris.goodnow@anu.edu.au",{"$nulls":8},"No"]
[8277,"CXCR5tg:P14","B6.Cg-Tg(Lck-Cxcr5)Cys Tg(TcrLCMV)#Sdz/MarpAnu",null,"Dominant",{"$nulls":25},"chemokine (C-X-C motif) receptor 5","lymphocyte protein tyrosine kinase",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-08-02","Cryopreserved sperm",24,0,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[{"$nulls":30},"transgene insertion, Birgit Ledermann"]
[8279,"Tet2fl/fl","B6.129-Tet2<tm1.1Iaai>/J",null,"Recessive","tet methylcytosine dioxygenase 2","Tet2",null,"Ayu17-449, E130014J05Rik, mKIAA1546","MGI:2443298","tet methylcytosine dioxygenase 2; targeted mutation 1.1, Iannis Aifantis","Tet2<tm1.1Iaai>","MGI:5141120","3",{"$nulls":28},"Normal (conditional line)","Normal (conditional line)","C57Bl/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-08-09","Cryopreserved sperm",40,0,null,null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[8283,"hIL21R:P14","B6.Cg-Il21r<IL21R> Tg(TcrLCMV)#Sdz/Marp",null,"Recessive","interleukin 21 receptor","Il21r",null,"NILR","MGI:1890475",{"$nulls":3},"7",{"$nulls":16},"transgene insertion, Birgit Ledermann","H-2K<b> promoter",{"$nulls":11},"Carry LCMV-specific, H-2K<b>-restricted T cell receptor. Express human IL21R instead of mouse Il21R.","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-15",null,0,0,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[8286,"ASD749:Tacr3","C57BL/6NCrlAnu-Tacr3<en1Anu>/Anu",null,"Recessive","tachykinin receptor 3","Tacr3","Unknown","neuromedin K receptor, Nk3r, Tac3r","MGI:892968",{"$nulls":3},"3",{"$nulls":28},"Unknown",null,"C57BL/6JAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-08-21","Cryopreserved sperm",15,0,"ANU","749","true",null,"Nathalie","Dehorter","The Australian National University","nathalie.dehorter@anu.edu.au",{"$nulls":8},"No"]
[8289,"AMPK a1(T481/S487A) KI","C57BL/6-Prkaa1<em2(T481/S487A)>/Ausb",null,"Recessive","protein kinase, AMP-activated, alpha 1 catalytic subunit","Prkaa1","Unknown","AMPKalpha1, C130083N04Rik","MGI:2145955",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2017-08-22","Cryopreserved sperm",70,0,"St V",null,"true",null,"Bruce ","Kemp","St Vincent's Institute of Medical Reserach","bkemp@svi.edu.au",{"$nulls":3},"Lisa","Murray-Segal","lmsegal@svi.edu.au",null,null,"No"]
[8295,"HeparanaseKO","B6.129-Hpse<tm1Jpli>/AnuApb",null,"Recessive","heparanase","Hpse","Nil","Hpa","MGI:1343124","heparanase; targeted mutation 1, Jin-Ping Li","Hpse<tm1Jpli>","MGI:3844469","5",{"$nulls":28},"Heparanase KO mice are fertile with no immunological phenotype observed.","Normal.","C57BL/6JAnu","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-29","Cryopreserved sperm",58,0,"ANU",null,"false",null,"Chris","Parish","The Australian National University","Christopher.Parish@anu.edu.au",{"$nulls":8},"No"]
[8302,"IGFBP-3-null ","B6J.129S-Igfbp3<tm1Jep>",null,"Recessive","insulin-like growth factor binding protein 3","Igfbp3","Nil","IGFBP-3","MGI:96438","insulin-like growth factor binding protein 3; targeted mutation 1, John E Pintar","Igfbp3<tm1Jep>","MGI:3663361","11",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-12","Cryopreserved sperm",30,0,null,null,"false",null,"Giselle","Bellamy","Kolling Institute","Giselle.bellamy@health.nsw.gov.au",{"$nulls":8},"No"]
[8304,"Gpx4 fl","B6.129S6-Gpx4<tm1.1Qra>/JAnu",null,"Recessive","glutathione peroxidase 4","Gpx4","Unknown","1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase","MGI:104767","glutathione peroxidase 4; targeted mutation 1.1, Qitao Ran","Gpx4<tm1.1Qra>","MGI:5425616","10",{"$nulls":28},"Normal",null,"C57L/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-14",null,0,66,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[8303,"ObR fl","B6.129P2-Lepr<tm1Rck>/JAnu",null,"Recessive","leptin receptor","Lepr","Unknown","Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP","MGI:104993","leptin receptor; targeted mutation 1, Jeffrey M Friedman","Lepr<tm1Rck>","MGI:2176774","4",{"$nulls":28},"Normal",null,"C57L/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-09-14",null,0,0,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[8309,"CD19-cre.Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi> Cd19<tm1(Cre)Cgn>/AnuApb",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[8313,null,"ASD696:Thunderbird:19del::N1",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-09-28","Cryopreserved sperm",11,0,"ANU","696","true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":8},"No"]
[8311,"Surge","C57BL/6NCrlAnu-Foxb1<em1Anu>/AnuApb",null,"Recessive","forkhead box B1","Foxb1","Unknown","C43, Fkh5, Foxb1a, Foxb1b, Hfh-e5.1, Mf3, TWH","MGI:1927549",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2017-09-28","Cryopreserved sperm",7,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8326,null,"C57BL/6NCcb",null,"Dominant","N/A",{"$nulls":4},"N/A",null,null,"Unknown",{"$nulls":28},"Wild type","Wild type","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-10-05","Cryopreserved sperm",80,0,null,null,"false",null,"Claudine","Bonder","Centre for Cancer Biology","Claudine.Bonder@unisa.edu.au",{"$nulls":8},"No"]
[8329,"ASD613:Pyro:8","C57BL/6NCrlAnu-Ptpn22<em1Anu>/AnuApb",null,"Recessive","protein tyrosine phosphatase, non-receptor type 22 (lymphoid)","Ptpn22","Unknown","70zpep, Ptpn8","MGI:107170",{"$nulls":3},"3",{"$nulls":28},"Unknown",null,"C57BL/6CrlAnu","Yes","Unknown","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2017-10-10","Cryopreserved sperm",33,0,"ANU","613","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Lucy","Morris","lucy.morris@anu.edu.au",null,null,"No"]
[1781,"Cathepsin L Knockout","C57BL/6-Cstl<tm1Cptr>/WehiAnuApb",null,"Recessive","cathepsin L","Ctsl","Unknown","1190035F06Rik, Cat L, major excreted protein, MEP","MGI:88564","cathepsin L; targeted mutation 1, Christoph Peters","Ctsl<tm1Cptr>","MGI:2136432","13",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-03","Cryopreserved sperm",60,0,"ANU",null,"false",null,"Christopher","Parish","The Australian National University","christopher.parish@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8338,"Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi>/AnuApb",null,"Recessive","early growth response 2","Egr2",null,"Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25","MGI:95296","early growth response 2; targeted mutation 3, Patrick Charnay","Egr2<tm3Pch>","MGI:2183227","10",{"$nulls":28},"Unknown",null,"C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",">10",null,null,"No","2017-10-27","Cryopreserved sperm",24,0,"ANU",null,"false",null,"Ian","Parish","The Australian National University","ian.parish@anu.edu.au",{"$nulls":8},"No"]
[8338,"Egr2f/f.Egr3-/-","B6.129-Egr2<tm3Pch> Egr3<tm1Jmi>/AnuApb",null,"Recessive","early growth response 3","Egr3","Nil","Pilot","MGI:1306780","early growth response 3; targeted mutation 1, Jeffrey Milbrandt","Egr3<tm1Jmi>","MGI:2180063","14"]
[8343,"ASD867","BALB/cNCrlAnu:Pink",null,"Dominant",{"$nulls":40},"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-11-03",null,0,51,"ANU","867","true",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":8},"No"]
[8350,"ASD726:Taco:3::N1F1","C57BL/6NCrlAnu-Tax1bp1<em2Anu>/AnuApb",null,"Recessive","Tax1 (human T cell leukemia virus type I) binding protein 1","Tax1bp1","Unknown","1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151","MGI:1289308","TAX1BP1-L307l",null,null,"6",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-14","Cryopreserved sperm",36,0,"ANU",null,"true",null,"Matthew","Cook","The Australian National University","Matthew.cook@anu.edu.au",{"$nulls":8},"No"]
[8358,"ASD869:Sumo","C57BL/6NCrlANU-Irak2<em1ANU>/AnuApb",null,"Recessive","interleukin-1 receptor-associated kinase 2","Irak2",null,"6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d","MGI:2429603",{"$nulls":3},"6",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-29","Cryopreserved sperm",11,0,"ANU","869","true",null,"The Australian","Phenomics Facility","The Australian National University","jenna.lowe@anu.edu.au",{"$nulls":8},"No"]
[8353,"TetTXNIP/Ve-cdh5-rtTA","C57BL/6-Tg(TetO-TXNIP) Tg(Cdh5-tTA)D5Lbjn/Apb",null,"Recessive",{"$nulls":25},"Human thioredoxin interacting protein",{"$nulls":11},"Human TXNIP expressed in endothelial cells after treatment with tetracycline.",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm",50,0,null,null,"true",null,"Jessica","Toolan","Heart Research Institute","jessica.toolan@hri.org.au",{"$nulls":8},"No"]
[8368,"Aire:Cbl-b:Rag1 KO","C57BL/6JSfdAnu-Aire<tm1Pltn> Cblb<tm1Pngr> Rag1<tm1Mom>/AnuApb",null,"Recessive","Casitas B-lineage lymphoma b","Cblb",null,"Cbl-b","MGI:2146430","Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":30},"C57BL/6JSfdAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,null,"sib x sib","No","2017-12-08","Cryopreserved sperm",22,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8367,"Cblb KO","B6(Cg)-Cblb<tm1Pngr>/AnuApb","B6(Cg)-Cblb<tm1Pngr>/AnuApb","Recessive","Casitas B-lineage lymphoma b","Cblb","Nil","Cbl-b","MGI:2146430","targeted mutation 1, Josef M Penninger","Cblb<tm1Pngr>","MGI:2180570","16",{"$nulls":15},"Yes",{"$nulls":12},"Homozygotes for targeted null mutations exhibit elevated IL2 production by T cells, develop spontaneous autoimmunity, and are highly susceptible to experimental autoimmune encephalomyelitis.",null,"C57BL/NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","2",null,null,"No","2017-12-08","Cryopreserved sperm",33,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8372,"NOD.H2b.SCID-/-","NOD.Cg-H2<b> Prkdc<scid>/BaxApb",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Nil","DNA-PK, DNA-PKcs, DNAPDcs, slip, XRCC7","MGI:104779","severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":15},"Yes",{"$nulls":3},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","SCID mutation prevents TCR and BCR rearrangements. This prevents maturation of B and T cells at very early stages of development. These mice, therefore lack, T and B cells in periphery. Please refer to MGI allele page for further information using the link above.Mice that are homozygous for the SCID mutation are viable, fertile, normal in size. This strain is immunocomprimised. Mice homozygous for the severe combined immune deficiency spontaneous mutation (Prkdcscid, commonly referred to as scid) are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Normal antigen-presenting cell, myeloid, and NK cell functions are strain dependent. scid mice carry a DNA repair defect and a defect in the rearrangement of genes that code for antigen-specific receptors on lymphocytes. Most homozygotes have no detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Thymus, lymph nodes, and splenic follicles are virtually devoid of lymphocytes. scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. Some scid mice will spontaneously develop partial immune reactivity. scid mice that have serum Ig levels greater than 1 ug/ml are considered \"leaky.\" scid leakiness is highly strain dependent, increases with age, and is higher in mice housed under non-SPF conditions. In general, scid leakiness is high on the C57BL/6J and BALB/cBy genetic backgrounds, low on the C3H/HeJ background, and even lower on the NOD/ShiLtSz background. NOD/ShiLtSz-Prkdcscid mice are both insulitis- and diabetes-free throughout life and serve as a diabetes-free control for comparison to NOD/ShiLtJ mice. Thymic lymphomas occur with high frequency, however, and life span typically is limited to only 8.5 months under specific pathogen-free conditions.Also contains congenic markers MHC haplotype H2ᵇThe NOD.H2ᵇstrain does not develop insulitis, cyclophosphamide-induced diabetes, or spontaneous diabetes, but does develop extensive lymphocytic infiltrates in the pancreas and the submandibular glands.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"19",null,"No","2017-12-11","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8373,"NOD.Nkrp1b.Nkt1","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au",{"$nulls":8},"No"]
[8380,"NOD.Nkrp1b.Nkt2e","NOD-Klrb1b<C57BL/6> Nktcn2e<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.","Differences in susceptibility to autoimmunity.","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-11",null,0,0,null,null,"true",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8385,"Prox1enhCRISPR-Banzai","C57BL/6-Prox1<em5Nlh>",null,"Recessive","prospero homeobox 1","Prox1",null,"A230003G05Rik","MGI:97772",{"$nulls":3},"1",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-12-18","Cryopreserved sperm",50,0,null,null,"true",null,"Natasha","Harvey","University of South Australia","Natasha.Harvey@unisa.edu.au",{"$nulls":8},"No"]
[8371,"NOD.H2b.Nkrp1b","NOD-H2<b> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; b variant","H2<b>","MGI:3579319","17","Mice that are homozygous for this allele are viable, fertile, normal in size.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@anu.edu.au",{"$nulls":8},"No"]
[8371,"NOD.H2b.Nkrp1b","NOD-H2<b> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm",{"$nulls":4},"false"]
[8377,"NOD.Nkrp1b.Slam1D","NOD-Klrb1b<C57BL/6> Nkt1<C57BL/6> Slam1D<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"natural killer T cell numbers 1","Nktcn1",null,"Nkt1","MGI:2681136","natural killer T cell numbers 1; C57BL/6J","Nktcn1<C57BL/6J>","MGI:2681149","1","Mice that are homozygous for this allele are viable, fertile and normal in size.Congenic Nk Cell Marker. Congenic Marker for NKT1 region. Congenic Marker for Slam1d region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-11","Cryopreserved sperm",{"$nulls":4},"true"]
[8395,"NOD.Nkrplb.Slam1D.CD-1","NOD-CD1<tm1Gru> Klrb1b<C57BL/6> Slamf1D<C57BL/6>/Bax",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.\"Mice can have trouble breeding. Keep a close eye on progress and increase breeders as required to maintain line. If a case of breeding ceasing, may need to cross back onto a parental line. Ideally NOD.Nkrplb.Nktl.SlamlD to reduce genotyping.Nkrplb:Congenic Nk Cell Marker. Nktl:Congenic Marker for NKT1 region. Increased Nkt cell numbers.CD-1:Knockout lacking the CD1 antigen complex gene.  Lack an NK-like cell subset.SlamlD:Congenic Marker for Slam1D region. Increased Nkt cell numbers.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8394,"NOD.Idd13.Nkrp1b.Cd-1-/-","NOD-CD1<tm1Gru> Idd13<C57BL/6> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"insulin dependent diabetes susceptibility 13","Idd13",null,null,"MGI:99415","insulin dependent diabetes susceptibility 13; C57BL/6","Idd13<C57BL/6>","MGI:3044074","2","Animals homozygous for CD1 KO mutation lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.Idd13:Idd13 is congenic for a 32 cM segment of Chr 2 extending from D2Mit274 through D2Mit343 that includes the insulin dependent diabetes susceptibility locus Idd13.H2b:Congenic markers MHC haplotype H2ᵇ. Nkrplb:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2ᵇ\"",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm",{"$nulls":4},"false"]
[8396,"NOD.Nkrp1b.Nkt2b.CD-1","NOD-Cd1<tm1Gru> Klrb1b<C57BL/6> Nktcn2b<C57BL/6>/Bax",null,"Recessive","CD1 antigen complex","Cd1","Nil",null,"MGI:102561","CD1 antigen complex; targeted mutation 1, Michael Grusby","Cd1<tm1Gru>","MGI:1857482","3",{"$nulls":19},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Difficult breeders. Have had to restart the breeding, multiple times due to the difficulty in getting them homozygous. Seems homozygous mice do not breed. Congenic Nk Cell Marker. Congenic Marker for NKT2 region. Increased Nkt cell numbers.Knockout lacking the CD1 antigen complex gene",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2017-12-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8400,"NOD.Trail","NOD.129-Tnfsf10<tm1Mjs>/MjsBax",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 10","Tnfsf10","Nil","A330042I21Rik, APO-2L, Trail","MGI:107414","tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Mark J Smyth","Tnfsf10<tm1Mjs>","MGI:2179709","3",{"$nulls":28}," Thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis.",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-12-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8405,"BALB.931-203.344-3855","BALB/c-Gasa<C57BL/6(931-203.344-3855)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au",{"$nulls":8},"No"]
[8410,"NOD.H2d.Nkrp1b","NOD-H2<d> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; d variant","H2<d>","MGI:3579320","17","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2d:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2d. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8410,"NOD.H2d.Nkrp1b","NOD-H2<d> Klrb1b<C57BL/6>/Bax",null,"Recessive",{"$nulls":28},"killer cell lectin-like receptor subfamily B member 1B","Klrb1b",null,"Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D","MGI:107539",{"$nulls":3},"6","Mice that are homozygous for this allele are viable, fertile, normal in size.Nkrplb:Congenic Nk Cell Marker.H2d:Congenic Nk Cell Marker. Congenic markers MHC haplotype H2d. ",null,"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,"Hom x Hom","No","2017-12-19","Cryopreserved sperm",{"$nulls":4},"false"]
[8418,"ENU39:064:Casp1:G3","C57BL/6NCrlAnu-Casp1<m1Anu>/AnuApb",null,"Recessive","caspase 1","Casp1","Unknown","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-17","Cryopreserved sperm",44,0,"ANU",null,"true",null,"The Australian","Phenomics facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au",null,null,"No"]
[8424,"ASD735:Cannonball:F0","C57BL/6NCrlAnu-Camk2d<em1Anu>/Anu",null,"Recessive","calcium/calmodulin-dependent protein kinase II, delta","Camk2d","Unknown","2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852","MGI:1341265","Camk2d C273s",null,null,"3",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-24","Cryopreserved sperm",56,0,"ANU",null,"true",null,"Nikki","Ross","The Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[8426,"RBC19","SJL-Tpi<RBC19>",null,"Semi-dominant","triosephosphate isomerase 1","Tpi1","Unknown","Tpi-1","MGI:98797","Tpi^F57S/F57S",null,null,"6",{"$nulls":28},"Macrocytosis and haemolytic anaemia, high MCV, low RBC, splenomegaly, viable and fertile.","Macrocytosis, high MCV.","SJL","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-01-25","Cryopreserved sperm",50,0,null,null,"false",null,"Ashlee","Conway","Australian Centre for Blood Diseases, Monash University","ashlee.conway@monash.edu",{"$nulls":8},"No"]
[8430,"RBC16","BALB/c-Cpox<m1Wehi>/WehiMarpApb",null,"Dominant","coproporphyrinogen oxidase","Cpox","Nil","cac, clone 560, Cpo, nct","MGI:104841","Cpox<W373X>",null,null,"16",{"$nulls":28},"Lethal (e9.5) ","Microcytosis (low MCV), low Hb","BALB/c","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-02-02",null,0,0,"Monash",null,"false",null,"Ashlee","Conway","Australian Centre for Blood Diseases","ashlee.conway@monash.edu",{"$nulls":8},"No"]
[8438,"TREML4 KO","C57BL/6-Treml4<em2>/Apb",null,"Recessive","triggering receptor expressed on myeloid cells-like 4","Treml4",null,"5031403H21Rik","MGI:1923239",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-02-16",null,0,0,null,null,"true",null,"Hamsa","Puthalakath","La Trobe University","h.puthalakath@latrobe.edu.au",{"$nulls":8},"No"]
[8436,null,"Actc1-TRE",null,"Dominant",{"$nulls":37},"Unknown",null,null,"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-02-09","Cryopreserved sperm",50,0,null,null,"false",null,"Rachel","Davey","The University of Melbourne","r.davey@unimelb.edu.au",{"$nulls":8},"No"]
[8450,"BALB.931-343","BALB/c-Gasa<C57BL/6(931-343)>/Bax",null,"Recessive",{"$nulls":28},"Unknown",{"$nulls":7},"Unknown","Altered response to induced neonatal thymectomy induced gastritis compared to BALB/c mcie.",null,"BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Hom x Hom","No","2018-03-19","Cryopreserved sperm",50,0,null,null,"false",null,"Alan","Baxter","James Cook University","alan.baxter@jcu.edu.au","Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University","Townsville, 4811","QLD",{"$nulls":5},"No"]
[8444,"ASD541:Lifr flox:Flpe:Cre-ERT2","B6(Cg)-Lifr<tm1c(EUCOMM)Hmgu>/AnuApb",null,"Recessive","leukemia inhibitory factor receptor","Lifr",null,"A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788",{"$nulls":3},"15",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-03-09","Cryopreserved sperm",36,0,"ANU","541","true",null,"Julia","Ellyard","Australian National University","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[8449,"35bp del","C57BL/6NCrlAnu-Arpc1b<em2Anu>/Anu",null,"Recessive","actin related protein 2/3 complex, subunit 1B","Arpc1b","Normal","L72, p41-ARC, SOP2Hs","MGI:1343142","actin related protein 2/3 complex, subunit 1B; targeted mutation 1a, Wellcome Trust Sanger Institute",null,null,"5",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm",22,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[773,"NMD4NML5","NOD-Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":10},"Abnormal B cell morphology:* there is no decrease in the number of B cells expressing the transgenic antibody compared to singly transgenic NOD mice that carry just the antibody transgene.* this suggests defect in the NOD strain of deleting B cells that recognize soluble self antigens.Abnormal B cell clonal deletion:* Background Sensitivity: the normal number of B cells found in these mice demonstrate a defect in the NOD strain of deleting B cells that recognize soluble self antigens.Decreased IgM level:* very little IgM is detectable in the sera despite the presence of soluble antigen for the transgenic antibody.Abnormal B cell anergy:* B cells expressing the transgenic antibody are anergic as determined by the lack of HEL specific antibody found in the sera.* anergy occurs both centrally (i.e. in the bone marrow) and in the periphery.* this anergy can be reversed by stimulating B cells in vitro.* when compared to singly transgenic controls, antibody production following BCR and CD40 stimulation is less suppressed in doubly transgenic NOD mice than in doubly transgenic C57BL/6 mice (2.6-fold less vs 4.5 fold less).","NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2007-05-18",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[700,null,"NOD.Cg-Igh-6<tm1Cgn> Tg(IghelMD4)4Ccg/Dvs",null,"Dominant",{"$nulls":25},"transgene insertion 4, Christopher C Goodnow",null,"High",{"$nulls":9},"Do not express endogenous IgM, viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.All B lymphocytes in NOD.Igh-6 deficient transgenic mice express Ig molecules specific for HEL.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-01",null,0,0,null,null,"true",null,"Pablo","Silveira","Garvan Institute","p.silveira@garvan.org.au",{"$nulls":3},"Pablo","Silveira","p.silveira@garvan.org.au","N/A","N/A","No"]
[789,"Y4 KO","B6.129-Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Nil","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14",{"$nulls":15},"Yes",{"$nulls":12},"Decreased body weight:* 4-week old females weigh significantly less than controlsWeight gain:* males and females gain significantly less weight between 4 and 16 weeks of age.Homeostasis/metabolism phenotype:* levels of leptin, insulin, and glucose do not differ from wild type.* testosterone tends to be lower in mutants but this does not become significant.Abnormal circulating pancreatic peptide level:males exhibit 2- to 3-fold higher plasma levels of pancreatic polypeptide (PP).Abnormal drinking behavior:* mutants drink more water during the dark phase, but this is only significant on the second and third days of the 3 day observation period.* this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan.Abnormal water consumption:* daily water intake is elevated only on second and third day compared to controls.* this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan.Abnormal food intake:* males have lower food intake/24 hours than wild type controlsIncreased aggression to other mice:* male mutants show very aggressive behavior, with instances of fighting between littermates causing injuries.* female mutants become aggressive toward littermates after 20-24 weeks of age.Decreased white adipose tissue amount:* male mice have a significantly lower mass of white adipose tissue (WAT) compared to controls.Abnormal fat pad:* mesenteric WAT is major contributor to reduced WAT mass (0.65 % of body weight in male mutant vs 0.84% in male wild type and 0.53% in female mutant vs 0.76% in female wild type).Abnormal mammary gland growth during pregnancy:* lobuloalveolar development is accelerated compared to wild type (lobuloalveolar content on day 16 is 18.74% area of 4th gland compared to 15.79% in wild type).",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-19",null,0,0,null,null,"true",null,"Herbert","Herzog","Garvan Institute","h.herzog@garvan.org.au",{"$nulls":3},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A","No"]
[809,"Y2 KO x Y4 KO","B6.129-Npy2r<tm1.1Hhz> Ppyr1<tm1.1Hhz>",null,"Recessive","pancreatic polypeptide receptor 1","Ppyr1","Unknown","Npy4r, NYYR-D, Y4","MGI:105374","targeted mutation 1.1, Herbert Herzog","Ppyr1<tm1.1Hhz>","MGI:2183929","14",{"$nulls":58},"Herbert","Herzog","h.herzog@garvan.org.au","N/A","N/A"]
[1835,"X linked GFP","Un-Tg(CAG-EGFP)D4Nagy/Wehi",null,"X-linked",{"$nulls":25},"transgene insertion D4, Andras Nagy","chicken beta-actin promoter and CMV intermediate early enhancer","Ubiquitous",{"$nulls":9},"Hemizygous males/Homozygous females will be fluorescent under dertain conditions due to the expression of GFP.  Transgene expression is seen as early as ~E2.75, as morula stage embryos begin to compact. Expression of GFP is spatiotemporally ubiquitous, though levels differ between different lineages (e.g., expression is slightly higher in the heart).",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-08",null,0,0,null,"WEHI #1118","true",null,"Elaine","Major","Walter and Eliza Hall Institute of Medical Research","emajor@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6233,"BXK","B6.129-Bak1<tm1Thsn> Bax<tm1Sjk>",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":28},"Partial neonatal lethality:*Majority die within 48 hours of birth, although some survive to adulthood.Interdigital webbing:*Mutants retain interdigital webs on both fore and rear paws.Vagina atresia:*Seen in all adult females.Circling:*Display circling behavior when exposed to external stress.Seizures:*Stress-induced seizure activity.Abnormal hearing physiology:*Unresponsive to auditory stimuli.Abnormal hematopoiesis:*Hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units.      Anemia:      *Mild anemia.      Increased leukocyte cell number:         Increased lymphocyte cell number:         *Increases within the circulation and the peripheral lymphoid organs.         *Lymphocytic infiltration is seen in parenchymal organs, liver, and kidney.      Decreased platelet cell number      Abnormal B cell morphology:      *B220+ B cells present in the lymph node and spleen are skewed toward a B220<bright>IgD- phenotype, indicating an increase in the number of class-switched or memory B cells.      Abnormal T cell morphology:      *T cells that accumulate in mutants are skewed toward a memory cell phenotype.Increased spleen red pulp amount:*Expanded red pulp contains a large increase in the number of plasma cells and histiocytes.Enlarged spleenIncreased spleen white pulp amount:*Pronounced hyperplasiaAbnormal splenocyte physiology:*Isolated splenocytes cultured in suspension show enhanced survival.Enlarged lymph nodesAbnormal brain morphology:*Increase in the number of neurons in multiple regions of the brain.*Large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region.      Increased brain sizeIncreased neuron number:*In multiple regions of the brain.Decreased cellular sensitivity to gamma-irradiation:*Thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation.Decreased physiological sensitivity to xenobiotic:*Thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death.",null,"C57BL/6","No","No","Yes","No","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"WEHI","3241","true",null,"David","Huang","Walter and Eliza Hall Institute of Medical Research","huang_d@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[6233,"BXK","B6.129-Bak1<tm1Thsn> Bax<tm1Sjk>",null,"Recessive","BCL2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7",{"$nulls":61},"N/A","N/A"]
[3434,"common beta chain + IL3 beta chain double KO","B6.129-Csf2rb<tm1Csc> Csf2rb2<tm2Cgb>/Wehi",null,"Recessive","colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)","Csf2rb","Nil","AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb","MGI:1339759","targeted mutation 1, Clare L Scott","Csf2rb<tm1Clsc>","MGI:3653883","15",{"$nulls":15},"Yes",{"$nulls":12},"Cells from mice generated with the doublytargeted embryonic stem cells wereunresponsive to GM-CSF, IL3 and IL5 cytokines. Alveolar proteinosis, normal lifespan.",null,"C57BL/6 x 129","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-16",null,0,0,null,"WEHI #307","true",null,"Lorraine","Robb","Walter and Eliza Hall Institute of Medical Research","robb@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[5556,"T14; IL1RA T14OX","B6;CBA-Tg(Il1rn)1Dih/Anu",null,"Dominant",{"$nulls":25},"transgene insertion 1, David Hirsh","IL1RA promoter",{"$nulls":10},"Increased circulating interleukin-1 level: serum IL-1 levels are higher following lipopolysaccharide (LPS) endotoxin challenge.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection.","Abnormal angiogenesis: reduced angiogenesis observed in stromal keratitis caused by herpes simplex virus (HSV) ocular infection, reduced vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) levels.Decreased circulating interleukin-6 level: reduced IL-6 levels in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Abnormal circulating serum amyloid protein level: 30% decrease in serum amyloid P levels after subcutaneous turpentine administration.Decreased susceptibility to endotoxin shock: less susceptible to lipopolysaccharide (LPS) endotoxin challenge, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.Decreased inflammatory response: reduced polymorphonuclear leukocyte infiltration in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection.Decreased susceptibility to viral infection: severity of stromal keratitis caused by herpes simplex virus (HSV) ocular infection is diminished.Increased susceptibility to bacterial infection: more susceptible to experimental Listeria monocytogenes infection, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown","2 since arrival at ANU",null,"No","2011-08-12",null,0,0,null,null,"true",null,"Julio","Licinio","The Australian National University","julio.licinio@anu.edu.au",{"$nulls":3},"Llara","Weaver","llara.weaver@anu.edu.au","N/A","N/A","No"]
[8455,"ASD866:F2","C57BL/6NCrlAnu:Orange:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"2","No","2018-04-06",null,0,0,"ANU","866","false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8456,"ASD866:F2","C57BL/6NCrlAnu:Yellow:F2",null,"Dominant",{"$nulls":37},"Normal",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06",null,0,279,"ANU","866","false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8461,"ASD872:F2","B6.SJL-Ptprc<a>/CrlAnu:Line A:F2",null,"Recessive","protein tyrosine phosphatase, receptor type, C","Ptprc",null,"B220, CD45, Ly-5, Lyt-4, T200","MGI:97810","protein tyrosine phosphatase, receptor type, C; a variant","Ptprc<a>","MGI:4819849","1",{"$nulls":30},"C57BL/6NCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,"2",null,"No","2018-04-06",null,0,255,"ANU","872","false",null,"The Australian","Phenomics Facility","The Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[8470,"Clec7a KO","B6.129-Clec7a<tm1Gdb>/JAnuApb",null,"Recessive","C-type lectin domain family 7, member a","Clec7a","Nil","beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1","MGI:1861431","C-type lectin domain family 7, member a; targeted mutation 1, Gordon D Brown","Clec7a<tm1Gdb>","MGI:3695710","6",{"$nulls":28},"Abnormal circulating interleukin level:• IL-22 production in response to Aspergillus fumigatus challenge is severely reducedDecreased circulating interleukin-17 level:• lower levels of IL-17A after lung infection with Aspergillus fumigatusLung inflammation:• impaired inflammatory reactivity of alveolar macrophage• impaired recruitment of macrophage to lungs• highly susceptible to lung infection with Aspergillus fumigatus• little antifungal activity in lung lavage fluidIncreased susceptibility to fungal infection:• highly susceptible to lung infection with Aspergillus fumigatusIncreased sensitivity to induced morbidity/mortality:• mice infected with sublethal dose of C. albicans have much lower survival rate compared to controlsAbnormal neutrophil physiology:• cells do not have beta-glucan dependent recognition of unopsonized zymosan; respiratory burst is attenuated when cultured with unopsonized yeast, and response is not fully restored when opsonized zymosan particles are usedAbnormal macrophage physiology:• thioglycollate-elicited macrophages show impaired recognition of zymosan (fungal beta-glucan particle); prior opsonization with mouse serum restores binding by macrophages• elicited mutant macrophages show impairment of cytokine production when cultured with zymosan• recognition of unopsonized yeast by macrophages is impaired compared to controlsAbnormal cytokine secretion:• mutant macrophages show impaired production of Il10 and Il12 when cultured with zymosanAbnormal inflammatory response:• inflammatory response to zymosan fails to occur; defect is specific for fungal particles as other microbial stimuli elicit a response• inflammatory response to yeast is not restored after opsonization of yeast with mouse serum, although fungal recognition is restored to macrophagesIncreased susceptibility to fungal infection:• mice infected with sublethal dose of C. albicans have much lower survival rate compared to controls• at day 9 after infection, mutant mice have higher fungal burdens than controls in the gastrointestinal tract; enhanced systemic dissemination of C. albicans is evident within 24 hours of infection• at time of death, mutant kidneys show enhanced fungal colonization by C. albicans, particularly in pelvic region with extension up renal tubules compared to controls which lack such colonization• fungal hyphae extend through tubular epithelium into interstitium and are surrounded by acute neutrophilic inflammation (invasive candidiasis)Enlarged stomach:• mice which succumb to infection show macroscopic enlargement of stomachAbnormal digestive system physiology:• mice which succumb to infection have stomachs full of food, suggesting blockage of gastrointestinal tract",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-13","Cryopreserved sperm",31,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.du.au",{"$nulls":8},"No"]
[3523,"NOD.B6 Idd1B","NOD.B6-Idd11<C57BL/6>",null,"Recessive",null,null,"Unknown",null,null,"insulin dependent diabetes susceptibility 11","Idd11","MGI:3036811","4",{"$nulls":15},"Yes",{"$nulls":12},"Non obese diabetic (NOD) mice exhibit a susceptibility to Spontaneous development of type 1 diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-28",null,0,0,null,"WEHI #903","true",null,"Tom","Brodnicki","Walter and Eliza Hall Institute of Medical Research","brodnicki@wehi.edu.au",{"$nulls":3},"Catheryn A","O'Brien","Obrien@wehi.edu.au","N/A","N/A","No"]
[8448,"W140S","C57BL/6NCrlAnu-Arpc1b<em1Anu>/Anu",null,"Recessive","actin related protein 2/3 complex, subunit 1B","Arpc1b","Normal","L72, p41-ARC, SOP2Hs","MGI:1343142","actin related protein 2/3 complex, subunit 1B; targeted mutation 1a, Wellcome Trust Sanger Institute",null,null,"5",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-03-19","Cryopreserved sperm",12,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8855,"Naip1-6 KO","B6.Cg-Del(13Naip1-Naip5)1Vnce Naip2<em2Vnce>/JAnu",null,"Recessive",{"$nulls":5},"deletion, Chr 13, Russell Vance 1","Del(13Naip1-Naip5)1Vnce","MGI:6246513","13",{"$nulls":28},"Homozygous Naip1-6Δ mice fail to respond to cytosolic flagellin, consistent with previous biochemical data implicating Naip6 in flagellin detection. They also fail to respond to type III secretion system needle or inner rod protein.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-02-12",null,0,30,"ANU",null,"false",null,"Si Ming","Man","Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[8862,"foz","BALB/c-Alms1<foz>/AnuTchApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Mice are hyperphagic leading to obesity . Males are sterile. High fat feeding accelerates obesity development. Compared to foz/foz mice on NOD.B10 background, BALB/c foz/foz mice do not develop diabetes and liver disease is less severe.","normal","BALB/c","Yes","Unknown","Yes","Yes","No","Yes","Yes","Good",">10",null,"heterozygote mating","No","2020-02-20",null,0,34,"ANU",null,"false",null,"Chris","Nolan","Australian National University","viviane.augusto@anu.edu.au",{"$nulls":8},"Yes"]
[8893,"ENU32:002","C57BL/6NCrlAnu-Pcgf5<m1Anu>/AnuApb",null,"Recessive","polycomb group ring finger 5","Pcgf5","Unknown",null,"MGI:1923505",{"$nulls":3},"19",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8",null,null,"No","2020-03-17","Cryopreserved sperm",22,0,"ANU",null,"true",null,"Lisa","Miosge","The Australian National University","lisa.miosge@anu.edu.au",{"$nulls":8},"No"]
[8881,"Nampt knockout","C57BL/6J-Nampt<em1Dunw>/DunwApb",null,"Recessive","nicotinamide phosphoribosyltransferase","Nampt","Unknown","1110035O14Rik, Pbef1, Visfatin","MGI:1929865",{"$nulls":3},"12",{"$nulls":28},"Homozygous loss of Nampt is embryonic lethal","Nampt heterozygous mice reported to have hydroencephaly, abnormal skin morphology and enlarged heart. No reported lethality","C57BL/6J","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2020-03-11","Cryopreserved sperm",40,0,null,null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":8},"No"]
[8463,"ASD598:Albiol:AireKO","B6.129-Aire<tm1Pltn> Hivep2<em1Anu>/AnuApb",null,"Recessive","human immunodeficiency virus type I enhancer binding protein 2","Hivep2",null,"Gm20114, MIBP1, Schnurri-2, Shn-2","MGI:1338076",{"$nulls":3},"10"]
[{"$nulls":30},"tetracycline transactivator","IEa"]
[8468,"Tcf7-GFP","C57BL/6-Tcf7<tm1Hhx>/HhxAnu",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1, Hai-Hui Xue","Tcf7<tm1Hhx>","MGI:5805838","11",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Using newly-generated Tcf7GFP reporter mice, we identified novel early innate lymphoid progenitors that express high levels of TCF-1 but lack surface markers of adaptive and innate lymphocyte lineages. These early innate lymphoid progenitors closely resemble bone marrow lymphoid progenitors at the transcriptome level, but lack efficient T and B lymphocyte potential. Instead, they efficiently gave rise to various ILC lineages, including conventional NK cells as well as cytokine-producing helper ILC at the clonal level, indicating that they are the earliest identifiable ILC progenitors. ",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-12","Cryopreserved sperm",19,0,"ANU",null,"true",null,"Di","Yu","The Australian National University","di.yu@anu.edu.au",{"$nulls":8},"No"]
[8888,"ASD723:Beast:DH314","C57BL/6NCrlAnu-Dhx58<em1Anu>/AnuApb",null,"Recessive","DEXH (Asp-Glu-X-His) box polypeptide 58","Dhx58","Unknown","B430001I08Rik, D11Lgp2e, LPG2","MGI:1931560",{"$nulls":3},"11",{"$nulls":28},"Unknown ","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-17","Cryopreserved sperm",33,0,"ANU","723","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8889,"ASD742:ZFRKO:ZF1bpins","C57BL/6NCrlAnu-Zfr<em1Anu>/AnuApb",null,"Recessive","zinc finger RNA binding protein","Zfr","Unknown","C920030H05Rik","MGI:1341890",{"$nulls":3},"15",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-17","Cryopreserved sperm",60,0,"ANU","742","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8846,null,"SJL/JAnu",null,"Dominant",{"$nulls":37},"Normal","Normal","SJL/J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-01-31","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Gaetan","Burgio","The Australian National University","gaetan.burgio@anu.edu.au",{"$nulls":8},"No"]
[8845,"Scn2a K905N conditional ","C57BL/6-Scn2a<em3>/Apb",null,"Recessive","sodium channel, voltage-gated, type II, alpha","Scn2a","Unknown",null,"MGI:98248",{"$nulls":3},"2",{"$nulls":28},"Unknown ","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-01-23","Cryopreserved sperm",50,0,null,null,"true",null,"Lynley","Cordeiro","Florey Institute of Neuroscience and Mental Health","lynley.cordeiro@florey.edu.au",{"$nulls":8},"No"]
[8849,"ASD1035:Melon:AC424","C57BL/6NCrlANu-Actr5<em1Anu>/AnuApb",null,"Recessive","ARP5 actin-related protein 5","Actr5","Unknown","B430109J19Rik","MGI:1924748",{"$nulls":3},"2",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-02-10","Cryopreserved sperm",72,0,"ANU","1035","true",null,"Qian","Shen","The Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8856,"Gp130Y757F;Dclk1(tm1a)","B6-Dclk1<tm1a(EUCOMM)Wtsi> Il6st<tm1Ern>/Apb",null,"Recessive","doublecortin-like kinase 1","Dclk1","Unknown","1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369","MGI:1330861","doublecortin-like kinase 1; targeted mutation 1a, Wellcome Trust Sanger Institute","Dclk1<tm1a(EUCOMM)Wtsi>","MGI:5543459","3",{"$nulls":28},"Gp130Y757F: spontaneous development of gastric adenomasDclk1(tm1a): targeted Dclk1 allele - hypomorph Dclk1  allele","Gp130Y757F: normalDclk1(tm1a): normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-02-14","Cryopreserved sperm",50,0,null,null,"true",null,"Michael","Buchert","Olivia Newton-John Cancer Research Institute","michael.buchert@onjcri.org.au",{"$nulls":8},"No"]
[8865,"Amigo2 KO:::A1A2A3","B6.Cg-Amigo1<tm1(KOMP)Vlcg> Amigo2<Gt(AI415330)tac> Amigo3<em1Anu>/AnuApb",null,"Dominant","adhesion molecule with Ig like domain 2","Amigo2","Unknown",null,"MGI:2145995",null,"Amigo2<Gt(AI415330)Tac>",null,"15"]
[8899,"DmdS3059E","C57BL/6-Dmd<em2>/Apb",null,"Recessive","Dystrophin, muscular dystrophy","Dmd","Unknown","Dp427, Dp71, Duchenne muscular dystrophy, dys, mdx, pke, X-linked muscular dystrophy","MGI:94909",{"$nulls":3},"X",{"$nulls":28},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-18","Cryopreserved sperm",40,0,null,null,"true",null,"Gordon","Lynch","The University of Melbourne","gsl@unimelb.edu.au",{"$nulls":8},"No"]
[7911,"B6.p53","B6.129-Trp53<tm1Tyj>/AnuApb",null,"Dominant","transformation related protein 53","Trp53","Nil","p44, p53","MGI:98834","transformation related protein 53; targeted mutation 1, Tyler Jacks","Trp53<tm1Tyj>","MGI:1857263","11",{"$nulls":28},"Premature death:* 90% had succumbed to tumors and died by 7 months of age.*average life span 160 days.Increased tumor incidence.Adenoma.Lymphoma.Thymic lymphoma: 75% of observed tumors were thymic lymphomasCarcinoma.Sarcoma.Abnormal apoptosis.Chromosome breakage: aneuploidyIncreased cellular sensitivity to ionizing radiation:* at P10, pattern and extent of oocyte loss in ovaries of mutants after exposure to 0.45 Gy radiation on P5 is similar to wild-type and much more sever than Trp63<tm2Fmc> mutants","Increased tumor incidence: age of onset 9 monthsLymphoma.Sarcoma","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2015-06-18","Cryopreserved sperm",120,0,"ANU","588","false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8904,null,"B6.D2-CHR12-STR1-Tg(fos-tau/LacZ)/Apb",null,"Dominant",{"$nulls":25},"FOS-TAU-LACZ",null,null,"Stress response QTL",{"$nulls":7},"12","Decreased activity in open field activity test. Increased stress responsiveness.Decreased fear memory.","Decreased activity in open field activity test. Increased stress responsiveness.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-19","Cryopreserved sperm",50,0,null,null,"false",null,"Yvette","Wilson","The University of Melbourne","y.wilson@unimelb.edu.au",{"$nulls":8},"No"]
[8911,"ASD765:Tnip1:TN346","C57BL/6NCrlAnu-Tnip1<em1Anu>/AnuApb",null,"Recessive","TNFAIP3 interacting protein 1","Tnip1","Unknown","A20-binding inhibitor of NF-kappa B activation, ABIN1, Nef, VAN","MGI:1926194",{"$nulls":3},"11",{"$nulls":28},"autoimmune phenotype","autoimmune phenotype","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-23","Cryopreserved sperm",32,0,"ANU",null,"true",null,"Carola ","Vinuesa",null,"carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8920,"Spi6 KO:Spi6 fl","C57BL/6-Serpinb9<GFP> Serpinb9<tm2.1Pib>/AnuApb",null,"Recessive","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9","Unknown","ovalbumin, PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-24","Cryopreserved sperm",22,0,"ANU","861","true",null,"David","Tscharke","Australian National University","david.tscharke@anu.edu.au",{"$nulls":3},"Lisa","Miosge","lisa.miosge@anu.edu.au",null,null,"No"]
[8920,"Spi6 KO:Spi6 fl","C57BL/6-Serpinb9<GFP> Serpinb9<tm2.1Pib>/AnuApb",null,"Recessive","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9",null,"ovalbumin, PI-9, Spi6","MGI:106603",{"$nulls":3},"13",{"$nulls":58},"Lisa","Miosge","lisa.miosge@anu.edu.au"]
[8933,"Aicda fl:mT/mG:mb1CreERT2","C57BL/6N(Cg)-Aicda<tm1c(EUCOMM)Hmgu> Gt(ROSA)26Sor<tm4(ACTB-tdTomato,-EGFP)Luo> Cd79a<tm3(cre/ERT2)Reth>/AnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Liqun Luo","Gt(ROSA)26Sor<tm4(ACTB-tdTomato,-EGFP)Luo>","MGI:3716464","6"]
[8927,"Aicdafl Mb1Cre ERT2:TCF7-GFP","B6(Cg)-Aicda<tm1c(EUCOMM)Hmgu> Cd79a<tm3(cre/ERT2)Reth> Tcf7<tm1Hhx>/MarpAnuApb ",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1, Hai-Hui Xue","Tcf7<tm1Hhx>","MGI:5805838","11"]
[8935,"ASD1059:WizzFizz","C57BL/6NCrlAnu-Fads2<em1Anu>/AnuApb",null,"Recessive","fatty acid desaturase 2","Fads2",null,"2900042M13Rik, Fads2a","MGI:1930079",{"$nulls":3},"19",{"$nulls":28},"Unknown.Mice homozygous for a null allele display absence of long-chain polyunsaturated fatty acids, infertility, arrest of spermiogenesis and folliculogenesis, and impaired platelet function. ",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-27","Cryopreserved sperm",23,0,"ANU","1059","true",null,"Giel","van Dooren","The Australian National University","giel.vandooren@anu.edu.au",{"$nulls":8},"No"]
[8477,"Traj18 KO","BALB/c-Traj18<em1>/Apb",null,"Recessive","T cell receptor alpha joining 18","Traj18","Nil","Gm17009","MGI:4440521",{"$nulls":3},"14",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-04-27","Cryopreserved sperm",30,0,null,null,"true",null,"Marcin","Ciula","University of Melbourne","mciula@unimelb.edu.au",{"$nulls":8},"No"]
[8943,"Ai14D:Cx3cr1-cre","B6.Cg-Cx3cr1<tm2.1(cre/ERT2)Litt> Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/JAnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor","Normal","beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 14, Hongkui Zeng","Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>","MGI:3809524","6",{"$nulls":30},"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-29","Cryopreserved sperm",56,0,"ANU","824","true",null,"Riccardo","Natoli","The Australian National University","riccardo.natoli@anu.edu.au",{"$nulls":8},"No"]
[8939,"ENU33:003:Ramos:1bp del","C57BL/6NCrlAnu-Tlr7<em1Anu> Trex1<m1Anu>/AnuApb",null,"Recessive","three prime repair exonuclease 1","Trex1",null,null,"MGI:1328317",{"$nulls":3},"9"]
[8954,"ASD1035:Melon:AC18bpdel","C57BL/6NCrlAnu-Actr5<em2Anu>/AnuApb",null,"Recessive","ARP5 actin-related protein 5","Actr5","Unknown","B430109J19Rik","MGI:1924748",{"$nulls":3},"2",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-30","Cryopreserved sperm",48,0,"ANU","1035","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8934,"Ighg1-cre Igk KO:Ly5a","B6.129P2(Cg)-Ighg1<tm1(cre)Cgn> Igk<tm1Dhu> Ptprc<a>/AnuApb",null,"Recessive","immunoglobulin kappa chain complex","Igk","Nil","kappa","MGI:96494","immunoglobulin kappa chain complex; targeted mutation 1, Dennis Huszar","Igk<tm1Dhu>","MGI:2429510","6",{"$nulls":28},"Homozygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioural abnormalities. They do exhibit a reduction in IgG1+ memory B cells and in IgG1 serum antibody titers.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-27","Cryopreserved sperm",24,0,"ANU",null,"false",null,"Carola ","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8953,"Blimp1 fl:CD23-cre","B6.Cg-Prdm1<tm2.1Nutt> Tg(Fcer2a-cre)5Mbu/WehiMarpAnuApb",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1",null,"b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1","MGI:99655","PR domain containing 1, with ZNF domain; targeted mutation 2.1, Stephen L Nutt","Prdm1<tm2.1Nutt>","MGI:4355900","10",{"$nulls":16},"transgene insertion 5, Meinrad Busslinger","Fcer2a",{"$nulls":12},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","10",null,null,"No","2020-03-30","Cryopreserved sperm",44,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8965,"ASD1041:Lettuce ; Irf4<L116R>","C57BL/6NCrlAnu-Irf4<em9Anu>/AnuApb",null,"Recessive","interferon regulatory factor 4","Irf4","Unknown","IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":28},"FACS Phenotype",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-04-05","Cryopreserved sperm",54,0,"ANU","1041","true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8963,"Fcho2Del2Ins","C57BL/6NCrlAnu-Fcho2<em2Anu>/AnuApb",null,"Recessive","FCH domain only 2","Fcho2","Unknown","5832424M12Rik","MGI:3505790",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-04-05","Cryopreserved sperm",58,0,"ANU","748","true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8356,"ASD666:Ramos:TtoC","C57BL/6NCrlAnu-Tlr7<em2Anu>/AnuApb",null,"X-linked","toll-like receptor 7","Tlr7",null,null,"MGI:2176882",null,"Tlr7<em2Anu>/Anu",null,"X",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-11-27","Cryopreserved sperm",33,108,"ANU","666","true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8967,"ENU7B6:039 (CD8)","B6(Cg)-Senp2<m1Anu>/AnuApb","B6(Cg)-Senp2<m1Anu>/AnuApb","Recessive","SUMO/sentrin specific peptidase 2","Senp2","Unknown",null,"MGI:1923076","SUMO/sentrin specific peptidase 2; mutation 1, The Australian National University","Senp2<m1Anu>","MGI:5563407","16","ENSMUSG00000022855","ENSMUST00000023561"," Senp2-201","939","1097","A to G","ENSMUSE00000131327","11","313","Glycine to Glycine",{"$nulls":4},"CTCCGATTTGAAAAGGAAGGTACAAGAGGACACCAAATGGAGCCTGATCTGTCAGAAGAAG","Yes",{"$nulls":12},"Subclinical autoimmune susceptibility. Antinuclear autoantibodies: homogeneous nuclear.Low CD8 protein expression and reduced T cell numbers.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","8 onto B6JAnu and then 3 onto C57BL/6NCrlAnu",null,null,"No","2020-04-05","Cryopreserved sperm",44,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8976,"ASD666:Ramos:1bp del","C57BL/6NCrlAnu-Tlr7<em1Anu>/AnuApb",null,"X-linked","toll-like receptor 7","Tlr7","Unknown",null,"MGI:2176882",{"$nulls":3},"X",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-04-11","Cryopreserved sperm",36,0,"ANU","666","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8974,"ASD940:Lef1 fl Tcf7 fl","B6(Cg)-Lef1<tm1Hhx> Tcf7<tm1c(EUCOMM)Wtsi> Gt(ROSA)26Sor<tm2Sho>/HhxAnuApb",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1c, Wellcome Trust Sanger Institute","Tcf7<tm1c(EUCOMM)Wtsi>","MGI:5816259","11"]
[8974,"ASD940:Lef1 fl Tcf7 fl","B6(Cg)-Lef1<tm1Hhx> Tcf7<tm1c(EUCOMM)Wtsi> Gt(ROSA)26Sor<tm2Sho>/HhxAnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Stuart Orkin","Gt(ROSA)26Sor<tm2Sho>","MGI:2136519","6"]
[8979,"NOD.B6 Idd11D","NOD/Lt-C57BL/6<(D4Mit72-D4Mit339)>/TcbApb",null,"Recessive","Insulin dependent diabetes locus 11","Idd11","Unknown",null,null,"Idd11","Idd11<C57BL/6>","96402","4",{"$nulls":19},"Insulin dependent diabetes locus 11","Idd11",null,null,"96402","insulin dependent diabetes susceptibility 11; C57BL/6","Idd11<C57BL/6>",null,"4","These homozygous congenic mice exhibit a decreased diabetes incidence compared to NOD/Lt wildtype mice.","Unknown","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Unknown","No","Good","10",null,null,"No","2020-04-12","Cryopreserved sperm",50,0,"St V",null,"false",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":8},"No"]
[8948,"ASD886:Cavendish:SH2bpdel","C57BL/6NCrlAnu-Sh2b3<em3Anu>/AnuApb",null,"Recessive","SH2B adaptor protein 3","Sh2b3",null,"Lnk","MGI:893598",{"$nulls":3},"5",{"$nulls":28},"unknown","unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-29","Cryopreserved sperm",35,0,"ANU","886","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8978,"NOD.B6Idd11G","NOD/Lt-C57BL/6<(D4Mit72 -rs27507071)>/TcbApb",null,"Recessive","insulin dependent diabetes susceptibility 11","Idd11","Unknown",null,"MGI:96402","insulin dependent diabetes susceptibility 11; C57BL/6 ","Idd11<C57BL/6>",null,"4",{"$nulls":19},"insulin dependent diabetes susceptibility 11; C57BL/6 ","Idd11",null,null,"96402","Idd11<C57BL/6>",null,null,"4","These homozygous congenic mice exhibit a decreased diabetes incidence compared to NOD/Lt wildtype mice.","Unknown","NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","10",null,null,"No","2020-04-12","Cryopreserved sperm",50,0,"St V",null,"false",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":8},"No"]
[8900,"Tip2#65","NOD/Lt-Tg(TetO-Ins2) Tg(H2-IEa-tTA)/Apb",null,"Dominant",{"$nulls":25},"transgene insertion",{"$nulls":11},"Normal","Normal","NOD/LtJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-18","Cryopreserved sperm",50,0,"St V",null,"false",null,"Gaurang ","Jhala","St.Vincents Institute for Medical Research","gjhala@svi.edu.au",{"$nulls":8},"No"]
[8778,"NODk","NOD.Cg-H2<k>/AnuApb",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; k variant","H2<k>","MGI:3579322","17",{"$nulls":28},"NODk mice are resistant to diabetes.",null,"NOD","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-15","Cryopreserved sperm",44,0,"ANU",null,"false",null,"Chris","Nolan","The Canberra Hospital","christopher.nolan@anu.edu.au",{"$nulls":8},"No"]
[8982,"Progesterone receptor; Isoform B (PRBKO)","B6;129S7-Pgr<tm2Omc>/J",null,"Recessive","progesterone receptor","Pgr","Nil","9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 2, Orla M Conneely","Pgr<tm2Omc>","MGI:2674932","9",{"$nulls":28},"Abnormal mammary gland growth during pregnancy:\t• reduction in both ductal sidebranching and development of alveolar lobules during pregnancy, seen as early as 7.5 days of pregnancy.Abnormal mammary gland epithelium morphology:\t• mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit a 30% decrease in proliferation of the ductal epithelium• mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit an increase in apoptosis in the alveolar epithelium.Abnormal branching of the mammary ductal tree:• reduction in the ductal sidebranching during pregnancy• mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in ductal sidebranching.Abnormal mammary gland alveolus morphology:• reduction in the development of alveolar lobules during pregnancy• at day 1 of lactation, glands show lower density of alveolar lobules than wild-type glands, however they do not appear underdeveloped• mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in lobuloalveolar development.Abnormal lactation:• even though females are able to lactate, offspring of homozygous mothers are growth retarded independent of their genotype, indicating lactational defectsReproductive system phenotype:N \t• in contrast to female mice lacking isoform A, female mice ovulate normally and are fertile.Abnormal mammary gland growth during pregnancy:• reduction in both ductal sidebranching and development of alveolar lobules during pregnancy, seen as early as 7.5 days of pregnancy",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-04-23","Cryopreserved sperm",50,0,null,null,"false",null,"Rebecca","Robker","The University of Adelaide","rebecca.robker@adelaide.edu.au",{"$nulls":8},"No"]
[8985,"BecSGTI/GFPLC3Tg","C57BL/6-Becn1<em2> Tg(CAG/CMV-GFP/LC3)/Apb",null,"Recessive","beclin 1, autophagy related","Becn1",null,"Atg6, MGC:6843","MGI:1891828",{"$nulls":3},"11",{"$nulls":16},"LC3-GFP",{"$nulls":11},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-04-28","Cryopreserved sperm",50,0,null,null,"true",null,"Erinna","Lee","La Trobe University","Erinna.Lee@latrobe.edu.au",{"$nulls":8},"No"]
[8019,"ePet-cre","B6.Cg-Tg(Fev-cre)1Esd/JAnu",null,"Dominant",{"$nulls":25},"transgene insertion 1, Evan S Deneris","ETS oncogene family","serotonergic-specific",{"$nulls":9},"NormalCre recombinase is expressed in serotonergic cells",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-01-26","Cryopreserved sperm",59,0,"ANU","664","true",null,"Guilherme","Silva","The Australian National University","Guilherme.Silva@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8989,"ENU15NIH:036a:uGFP","C57BL/6JAnu-Itgal<m2Anu> Tg(UBC-GFP)30Scha/AnuApb",null,"Recessive","integrin alpha L","Itgal","Unknown","Cd11a, LFA-1, Ly-15, Ly-21","MGI:96606",{"$nulls":3},"7",{"$nulls":16},"transgene insertion 30, Brian Schaefer","human ubiquitin C promoter",{"$nulls":12},"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-05-06","Cryopreserved sperm",33,0,"ANU",null,"false",null,"Ian","Cockburn","The Australian National University","ian.cockburn@anu.edu.au",{"$nulls":8},"No"]
[8980,"Progesterone receptor null mouse (PRKO) ","C.129S7(B6)-Pgr<tm1Bwo>/OmcJ",null,"Recessive","progesterone receptor","Pgr","Nil","9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B","MGI:97567","progesterone receptor; targeted mutation 1, Bert W O'Malley","Pgr<tm1Bwo>","MGI:1857933","9",{"$nulls":28},"Abnormal decidualization:• following estrogen and progesterone treatment and mechanical stimulation of the left uterine horn, female homozygotes fail to elicit a typical decidual response, whereas similarly-treated age-matched wild-type females show a greater than 20-fold increase in weight and extensive vascularization of the stimulated horn.Absent corpus luteum:• unlike wild-type mice, PMSG- and hCG-treated female homozygotes show absence of functional corpora lutea at 24 hrs after hCG administration.Increased mature ovarian follicle number:• unlike wild-type mice, PMSG- and hCG -treated female homozygotes display an unexpectedly large number of intact mature preovulatory follicles (unruptured follicles) even at 24 hrs after hCG administration• notably, these follicles are able to undergo strong cumulus cell expansion and dispersion.Uterus inflammation:• following estrogen and progesterone treatment, ovariectomized virgin female homozygotes display abnormal thickening of the uterine wall by extracellular edema, acute inflammatory cells, and proliferation of mucosal and glandular epithelia.• inflammatory changes are restricted to the mucosa, submucosa, and stromal components of the endometrium• a moderate PMN leukocyte infiltration is noted in both endometrial stroma and the overlying luminal epithelium, which appears hyperplastic and disorganized.Abnormal uterus morphology:• following estrogen and progesterone treatment, ovariectomized virgin female homozygotes display an abnormal uterine structure, including hyperplastic luminal and hypertrophic grandular epithelia, loosely arranged stromal layer, and presence of PMN leukocytes.• in contrast, uteri isolated from intact untreated female homozygotes show a normal myometrial and endometrial compartment relative to wild-type females.Enlarged endometrial glands:• following estrogen and progesterone treatment, ovariectomized female homozygotes display greatly enlarged endometrial glands lined by hypertrophied epithelia.Uterus hyperplasia:• following estrogen and progesterone treatment, 6-wk-old ovariectomized virgin female homozygotes display hyperplastic luminal and hypertrophic glandular epithelia.Dilated uterus:• following estrogen and progesterone treatment, 6-wk-old ovariectomized virgin female homozygotes display an abnormally distended fluid-filled uterus relative to age-matched, similarly-treated wild-type females.Anovulation:• unlike wild-type mice, female homozygotes fail to undergo superovulation and produce no oocytes following treatment with exogenous gonadotropins (PMSG and hCG).Female infertility:• adult female homozygotes are infertile when mated with wild-type male mice• in contrast, male homozygotes are fully fertile.Impaired luteinization:• granulosa cells located near the oocyte or positioned near the intact basal lamina of unruptured follicles from PMSG- and hCG -treated female homozygotes display no signs of luteinizationAbnormal mammary gland development:• following treatment with pregnancy levels of estrogen and progesterone, ovariectomized female homozygotes show a severely reduced mammary gland development relative to similarly-treated wild-type females.Abnormal branching of the mammary ductal tree:• following estrogen and progesterone treatment, inguinal mammary glands of ovariectomized female homozygotes exhibit a striking absence of lobuloalveolar development in terminal end buds and a less complex ductal structure with fewer dichotomous and lateral side branches than wild-type mammary glands.Abnormal osteoclast morphology:• at 26 weeks, mice exhibit a tendency towards reduced osteoclast perimeter/bone perimeter and osteoclast perimeter/tissue area compared with wild-type mice.Abnormal humerus morphology:• at 12 weeks, total humoral volume is increased compared to in wild-type mice• the humorus exhibit a tendency for increased cross-sectional volume compared to in wild-type mice• mice exhibit an increase in total, cancellous, and cortical bone mass compared with wild-type mice.Abnormal tibia morphology:• between 6 weeks and 26 weeks, mice exhibit an increase in tibia cross-section area unlike in wild-type mice.Increased compact bone thickness:• at the midshaft of the humorus.Abnormal trabecular bone morphology:• at 6 weeks, mice exhibit less trabecular separation than in wild-type mice• mice fail to exhibit a difference in trabecular separation between week 6 and week 12 unlike wild-type mice• at 26 weeks, mice exhibit an increase in trabecular number and a decrease in trabecular separation unlike in wild-type mice• cancellous bone volume at the epiphysis of the humerus is increased due to increased trabecular thickness compared to in wild-type mice.Increased trabecular bone thickness:• in the humorus.Increased bone mass:• mice exhibit an increase in total, cancellous, and cortical bone mass compared with wild-type mice• however, cortical and cancellous bone mass in the tibia is normal at 12 weeks.Abnormal bone ossification:• at 26, mice exhibit increased mineralizing perimeter/bone perimeter and bone formation rate/tissue area compared with wild-type mice","Normal","BALB/cx129xB6","Yes","No","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-04-23","Cryopreserved sperm",50,0,null,null,"false",null,"Rebecca","Robker","The University of Adelaide","rebecca.robker@adelaide.edu.au",{"$nulls":8},"No"]
[8527,"ASD778:Lrrfip1","C57BL/6NCrlAnu-Lrrfip1<em1Anu>/AnuApb",null,"Recessive","leucine rich repeat (in FLII) interacting protein 1","Lrrfip1","Unknown","FLAP (FLI LRR associated protein), Fliiap1","MGI:1342770",{"$nulls":3},"1",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-06-27","Cryopreserved sperm",11,0,"ANU","778","false",null,"Si","Ming","ANU","siming.man@anu.edu.au",{"$nulls":8},"No"]
[8994,"CaMK4(M306V) KI","C57BL/6-Camk4<em1(M306V)>/StVApb",null,"Recessive","calcium/calmodulin-dependent protein kinase IV","Camk4",null,"A430110E23Rik, Ca2+/calmodulin-dependent protein kinase type IV/Gr, CaMKIV, CaMKIV/Gr, D18Bwg0362e ","MGI:88258",{"$nulls":3},"18",{"$nulls":28},"Unknown","Normal","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown","once",null,null,"No","2020-05-26","Cryopreserved sperm",50,0,"St V",null,"true",null,"John","Scott","St Vincent's Institute of Medical Research","jscott@svi.edu.au",{"$nulls":8},"No"]
[8535,"TLR9-/-","B6.129-Tlr9<tm1Aki>/AkiApb",null,"Recessive","toll-like receptor 9","Tlr9",null,null,"MGI:1932389","toll-like receptor 9; targeted mutation 1, Shizuo Akira","Tlr9<tm1Aki>","MGI:2660562","9",{"$nulls":28},"Abnormal immune system physiology:• response to LPS and CpG is completely abrogatedImpaired natural killer cell mediated cytotoxicity :• no NK cell activation is observed following infection with L. infantum.Decreased interferon-alpha secretion:• following infection with Leishmania baziliensis• however, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.Decreased interferon-beta secretion:• following infection with Leishmania baziliensis• however, secretion could be restored by treatment with GU-rich ssRNA, a TLR7 ligand.Decreased interleukin-12b secretion:\t• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice (J:118954)• unlike in wild-type mice, IL-12p40 production from dendritic cells following infection with Leishmania infantum is indetectable.Decreased tumor necrosis factor secretion:\t• following treatment with PbA(Plasmodium bergbei ANKA)-parasitized erythrocytes or LPS-stimulation, TNF secretion is reduced.Decreased susceptibility to experimental autoimmune encephalomyelitis:\t• myelin oligodendrocyte glycoprotein injection results in delayed onset of disease, 17.9 days after injection rather than 15.9 days as in controls• fewer infiltrating foci in the spinal cord.Abnormal response to infection:• following treatment with PbA (Plasmodium bergbei ANKA)-parasitized erythrocytes, mice have a partially decreased immune response in terms of TNF secretion and response to CpG.Decreased susceptibility to parasitic infection:• resistant to cerebral malaria• reduced accumulation of hemozoin• less upregulation of TNF-alpha in Plasmodium infection","Normal.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-07-10",null,0,0,null,null,"true",null,"Eden","Whitlock","Peter Doherty Institute of Infection and Immunity","eden.whitlock@unimelb.edu.au",{"$nulls":8},"No"]
[8997,"Irf4TomatoGfp","C57BL/6-Irf4<tdTomato/GFP>/Apb",null,"Dominant","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip","MGI:1096873",{"$nulls":3},"13",{"$nulls":28},"Normal in homeostasis, but immune response is altered.","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-05-27","Cryopreserved sperm",50,0,null,null,"true",null,"Axel","Kallies","The University of Melbourne","axel.kallies@unimelb.edu.au",{"$nulls":8},"No"]
[9005,"Ndst1 fl x FoxN1 cre","B6.129-Ndst1<tm1Je> Foxn1<tm3(cre)Nrm>/AnuApb",null,"Recessive","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1","Ndst1","Normal","1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1","MGI:104719","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Jeffrey D Esko","Ndst1<tm1Je>","MGI:3589211","18",{"$nulls":29},"Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",">10",null,null,"No","2020-06-12","Cryopreserved sperm",11,0,"ANU",null,"false",null,"Chris","Parish","Australian National University","christopher.parish@anu.edu.au",{"$nulls":8},"No"]
[9003,"Cd11c-cre-GFP:Ndst1 fl","B6.129-Ndst1<tm1Je> Tg(Itgax-cre,-EGFP)4097Ach/AnuApb",null,"Recessive","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1","Ndst1","Normal","1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1","MGI:104719","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Jeffrey D Esko","Ndst1<tm1Je>","MGI:3589211","18",{"$nulls":16},"transgene insertion 4097, Alexander V Chervonsky","Itgax",{"$nulls":11},"Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",">10",null,null,"No","2020-06-12","Cryopreserved sperm",42,0,"ANU",null,"false",null,"Chris","Parish","Australian National University","christopher.parish@anu.edu.au",{"$nulls":8},"No"]
[9007,"Hs6st1 fl x FoxN1 cre:TCRb-transgenic","B6.129-Hs6st1<tm1Wvc> Foxn1<tm3(cre)Nrm> Tg(CD2-mTcrb)/AnuApb",null,"Recessive","heparan sulfate 6-O-sulfotransferase 1","Hs6st1","Normal","6)ST1","MGI:1354958","heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Wellington V Cardoso","Hs6st1<Wvc>","MGI:3793786","1",{"$nulls":16},"CD2-mTcrb",{"$nulls":12},"Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",">10",null,null,"No","2020-06-12",null,0,0,"ANU",null,"false",null,"Chris","Parish","Australian National University","christopher.parish@anu.edu.au",{"$nulls":8},"No"]
[9017,"Kingsleys #7","C57BL/6NCrlAnu-Rab13<em2Anu>/AnuApb",null,"Recessive","RAB13, member RAS oncogene family","Rab13","Unknown","610007N03Rik, B230212B15Rik","MGI:1927232",{"$nulls":3},"3",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-06-18","Cryopreserved sperm",59,0,"ANU","1058","false",null,"The Australian","Phenomics Facility","Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[9036,"Lifr fl:LysMcre","B6.129P2-Lifr<tm1c(EUCOMM)Hmgu> Lyz2<tm1(cre)Ifo>/JAusbAnuApb",null,"Recessive","lysozyme 2","Lyz2","Normal","Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp","MGI:96897","lysozyme 2; targeted mutation 1, Irmgard Forster","Lyz2<tm1(cre)Ifo>","MGI:1934631","10",{"$nulls":28},"Unknown","Enlarged spleen:*Rare","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-06-26","Cryopreserved sperm",33,0,"ANU","975","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[9036,"Lifr fl:LysMcre","B6.129P2-Lifr<tm1c(EUCOMM)Hmgu> Lyz2<tm1(cre)Ifo>/JAusbAnuApb",null,"Recessive","leukemia inhibitory factor receptor","Lifr",null,"A230075M04Rik, soluble differentiation-stimulating factor receptor","MGI:96788","leukemia inhibitory factor receptor; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Lifr<tm1c(EUCOMM)Hmgu>",null,"15"]
[9046,"IRF3","B6.Cg-Irf3<tm2.2Ttg>",null,"Recessive","interferon regulatory factor 3","Irf3","Unknown",null,"MGI:6353293",{"$nulls":3},"7","ENSMUSG00000003184","ENSMUST00000003284.15","Irf3-201",{"$nulls":16},"Irf3",{"$nulls":7},"7","Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level.","Unknown","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown",null,"Homozygote x Homozygote, Homozygous x B6, Het x het","Yes","2020-07-21",null,0,42,"ANU",null,"false",null,"Simon","Jiang","JCSMR Immunology and Infectious Diseases","simon.jiang@anu.edu.au",{"$nulls":3},"Dominik","Spensberger","dominik.spensberger@gmail.com",null,null,"No"]
[{"$nulls":30},"transgene insertion 1, Derek LeRoith","Albumin"]
[9060,"MDM2 C305F","B6(Cg).129(Cg)-Mdm2 <tm1.1Ypz>/AnuNCrl",null,"Recessive","Transformed mouse 3T3 cell double minute 2","MDM2","Normal","1700007J15Rik, Mdm-2 ","MGI:96952","Transformed mouse 3T3 cell double minute 2; targeted mutation 1.1, Yangping Zhang","Mdm2<tm1.1Ypz>","MGI:4836988","10",{"$nulls":28},"Homozygote animals smaller in size but otherwise normal","Heterozygote animals smaller in size (less pronounced than homozygotes) but otherwise normal.","C57.BL6 AnuNCrl","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-08-14","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Ross","Hannan","Australian National University","ross.hannan@anu.edu.au",{"$nulls":8},"No"]
[9066,"ENU48:125:St3gal5","C57BL/6NCrl<ENU48>/ApbAnu",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-08-28","Cryopreserved sperm",40,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[9030,null,"B6.Cg-Rag1<tm1> Ptprc<a> Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/JApb",null,"Recessive","recombination activating 1","Rag1",null,"Rag-1","MGI:97848",{"$nulls":3},"2",{"$nulls":16},"transgene insertion P25, Kiyoshi Takatsu","H-2Kb promoter",{"$nulls":10},"These P25 TCR-Tg transgenic mice contain CD4 + T cells expressing a T-cell antigen receptor that recognizes Mycobacterium tuberculosis antigen. They are bred onto the RAg-1-/- and express the congenial marker Ly5.1. These mice may be useful for studying the process of the adaptive immune response to M. tuberculosis infection in the lungs.","same as homozygous","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-06-24",null,0,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":8},"No"]
[9033,"Hardy","C57BL/6NCrlAnu-Igf1r<em1Anu>/AnuApb",null,"Recessive","insulin-like growth factor I receptor","Igf1r","Unknown","A330103N21Rik, CD221, hyft, IGF-1R, line 186","MGI:96433",{"$nulls":3},"7",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-06-26","Cryopreserved sperm",55,0,"ANU","972","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Paula","Gonzalez","paula.gonzalez@anu.edu.au",null,null,"No"]
[7366,"BCL6-flox ","B6.129-Bcl6<tm1.1Dent>/AnuApb",null,"Recessive","B cell leukemia/lymphoma 6","Bcl6","Normal","Bcl5","MGI:107187","B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent","Bcl6<tm1.1Dent>","MGI:5518542","16",{"$nulls":28},"Normal",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-03","Cryopreserved sperm",77,0,"ANU",null,"true",null,"Carola","Vinuesa","The Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8992,"GAD67","B6.Cg-Gad1<tm1.1Tama>/AnuApb",null,"Dominant","glutamate decarboxylase 1","Gad1",null,"EP10, Gad-1, GAD25, GAD44, GAD67, Z49976","MGI:95632","glutamate decarboxylase 1; targeted mutation 1.1, Nobuaki Tamamaki","Gad1<tm1.1Tama>","MGI:3590301","2",{"$nulls":28},"Homozygous animals die at birth.","Expresses enhanced GFP (green fluorescent protein) in GABA-expressing inhibitory neurons in the brain.","C57BL/6NCrlAnu","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2020-05-20","Cryopreserved sperm",55,0,"ANU","134","true",null,"John","Bekkers","Australian National University","John.Bekkers@anu.edu.au",{"$nulls":8},"No"]
[{"$nulls":30},"transgene insertion 10395, Bernd Arnold"]
[9049,"ENU33::Prkcd:Ifnar-/-","C57BL/6NCrlAnu-Prkcd<m1Anu>Ifnar1<tm1Agt>/AnuApb ",null,"Recessive","protein kinase C, delta","Prkcd ","Unknown","D14Ertd420e, Pkcd, PKC[d], PKCdelta ","MGI:97598",{"$nulls":3},"14",{"$nulls":28},"Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.","Unknown","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-07-31","Cryopreserved sperm",22,0,"ANU",null,"true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[8665,null,"ASD1000:Corn",null,"Recessive","Corn",{"$nulls":7},"Unknown",{"$nulls":31},"Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-26","Cryopreserved sperm",11,0,"ANU","1000","true",null,"The Australian","Phenomics Facility","The Australian National University","jenna.lowe@anu.edu.au",{"$nulls":8},"No"]
[9069,"ASD891:Sorghum","C57BL/6N-NLRP9a<em1Ming>/Apb",null,"Recessive","NLR family, pyrin domain containing 9A","Nlrp9a ",null,"D7Ertd565e, Nalp9a, Nalp-theta","MGI:2675292","NLR family, pyrin domain containing 9A ","Nlrp9a<em1Ming>",null,"7",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2020-09-01","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Si Ming","Man","JCSMR Immunology and Infectious Diseases","Siming.man@anu.edu.au",{"$nulls":3},"Chinh","Ngo","Chinh.ngo@anu.edu.au",null,null,"No"]
[9039,"FANCM KO","C57BL/6-FancM<em1>/Apb",null,"Recessive","Fanconi anemia, complementation group M","Fancm",null,"C730036B14Rik, D12Ertd364e","MGI:2442306",{"$nulls":3},"12","ENSMUSG00000055884","ENSMUST00000058889.4\t","Fancm-201",{"$nulls":25},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2020-07-10","Cryopreserved sperm",50,0,null,null,"true",null,"Wayne ","Crismani","St Vincent’s Institute of Medical Research ","wcrismani@svi.edu.au",{"$nulls":3},"Vanessa","Tsui","vtsui@svi.edu.au",null,null,"No"]
[9061,"GBPchrom3","B6.Gbp<chr3>",null,"Recessive","Guanylate binding protein 3","Gbp3","Reduced",null,"MGI:1926263",{"$nulls":3},"3","ENSMUSG00000028268","ENSMUST00000106221.7","Gbp3-202",{"$nulls":55},"Si Ming ","Man ","Siming.man@anu.edu.au"]
[9041,"Asciz<fl> Mb-1<Cre> Dynll1<fl>","Atmin<tm1.2Jhh> Cd79<atm1(cre)Reth> Dynll1<tm1.1Jhh>",null,"Recessive","ATM interactor","Atmin ","Reduced","Asciz, gpg6, MGC:79206, mKIAA0431 ","MGI:2682328","ATM interactor; targeted mutation 1.2, Jorg Heierhorst","Atmin<tm1.2Jhh>","MGI:5463937","8",{"$nulls":16},"CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth","Cd79a","Unknown",{"$nulls":9},"Severe reduction of B cell numbers (in Asciz f/f Mb1-Cre Ki/+ Dynll1 f/f conditional cKO mice)","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2020-07-14","Cryopreserved sperm",50,0,null,null,"false",null,"Joerg","Heierhorst","St. Vincent's Institute of Medical Research","jheierhorst@svi.edu.au",{"$nulls":8},"No"]
[9041,"Asciz<fl> Mb-1<Cre> Dynll1<fl>","Atmin<tm1.2Jhh> Cd79<atm1(cre)Reth> Dynll1<tm1.1Jhh>",null,"Recessive","Dynein light chain LC8-type 1","Dynll1 ",null,"8kDa LC, DLC8, Dnclc1, Pin","MGI:1861457","Dynein light chain LC8-type 1; targeted mutation 1.1, Jorg Heierhorst","Dynll1<tm1.1Jhh>","MGI:5755433","5"]
[8564,"CD4MLL1EED","B6.129-Kmt2a<tm1.2Erns>/Apb",null,"Recessive","lysine (K)-specific methyltransferase 2A","Kmt2a","Nil","All1, ALL-1, Cxxc7, HTRX1, Mll, Mll1, trithorax Drosophila","MGI:96995","lysine (K)-specific methyltransferase 2A; targeted mutation 1.2, Patricia Ernst","Kmt2a<tm1.2Erns>","MGI:3839795","9",{"$nulls":28},"normal","normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-09-18",null,0,0,null,null,"true",null,"Sebastian","Scheer","Monash University","sebastian.scheer@monash.edu",{"$nulls":8},"No"]
[9070,"Myostatin KO","BALB/c-Mstn<tm1Sjl>/APB",null,"Recessive","Myostatin","Mstn","Reduced","Gdf8","MGI:95691","myostatin; targeted mutation 1, Se-Jin Lee","Mstntm1Sjl","MGI:2148177","1","NCBI Gene: 17700",{"$nulls":27},"Increased muscle mass","Increased muscle mass","BALB/c","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-09-03","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Andrew","Jarnicki","University of Melbourne","andrew.jarnicki@gmail.com",{"$nulls":8},"No"]
[7371,"ENU26:044:G6pc:B6:G2","C57BL/6NCrlAnu-G6pc<m1Anu>/AnuApb",null,"Recessive","glucose-6-phosphatase, catalytic","G6pc","Unknown","G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha","MGI:95607","mutation 1, The Australian National University","G6pc<m1Anu>",null,"11","ENSMUSG00000078650","ENSMUST00000019469","G6pc-001","248","484","G to T","ENSMUSE00000113003","2","83","Arginine to Leucine",{"$nulls":4},"CGTCTTCAAGTGGATTCTGTTTGGACAACGCCCGTATTGGTGGGTCCTGGACACCGACTAC",{"$nulls":13},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2013-07-05","Cryopreserved sperm",55,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au","N/A",null,"No"]
[4508,"ENU7B6:071","C57BL/6JAnu-Ltb<m1Anu>/AnuApb",null,"Recessive","lymphotoxin B","Ltb",null,"LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3","MGI:104796",null,"Ltb<m1Anu>",null,"17","ENSMUSG00000024399","ENSMUST00000025262","Ltb-001","623","706","G to A","ENSMUSE00000930622","3","208","Arginine to Lysine",{"$nulls":4},"CTATTACCTCTACTGCCACGTCGGGTACAGGGGCAGGACGCCCCCTGCCGGCCGAAGCCGT","Yes",{"$nulls":12},"Defective antibody response to immunization: failure to mount a normal Th1 polarized IgG2c antibody response to heat killed B pertussis bacteria. ",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2009-02-26","Cryopreserved sperm",83,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Anselm","Enders","anselm.enders@anu.edu.au","N/A","N/A","No"]
[8579,"Tweak KO/C57BL/6 ","C57BL/6-Tnfsf12<tm1>/Apb",null,"Recessive","tumor necrosis factor (ligand) superfamily, member 12","Tnfsf12",null,"APO3L, DR3L, Tweak","MGI:1196259",{"$nulls":3},"11",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-10-02","Cryopreserved sperm",50,0,null,null,"true",null,"Amelia","Johnston","La Trobe University","a.johnston@latrobe.edu.au",{"$nulls":8},"No"]
[8706,"Pedro:PR36 SJ","C57BL/6-Prdm1<em3Anu>/AnuApb",null,"Recessive","PR domain containing 1, with ZNF domain","Prdm1","Unknown","b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1","MGI:99655",{"$nulls":3},"10",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-05-03","Cryopreserved sperm",36,0,"ANU",null,"true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8735,"ASD976:Gomez:2:N1","C57BL/6NCrlAnu-Ryr2<em3Anu>/AnuApb",null,"Recessive","ryanodine receptor 2, cardiac","Ryr2","Unknown","9330127I20Rik","MGI:99685",{"$nulls":3},"13",{"$nulls":28},"Normal","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-19","Cryopreserved sperm",11,0,"ANU","976","true",null,"Nikki","Ross","Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[9077,"Rag1 KO:Charles","RAG:CharlesHom:B6",null,"Dominant",".",".",{"$nulls":6},"Unknown",{"$nulls":28},"unknown","unknown",".","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-09-10",null,0,0,null,null,"true",null,"Dominik","Spensberger",null,"Dominik.Spensberger@anu.edu.au",{"$nulls":8},"No"]
[9040,"FANCM-LoxP","C57BL/6-FancM<em1(loxP)>/Apb",null,"Recessive","Fanconi anemia complementation group M","FancM",null,"C730036B14Rik, D12Ertd364e ","MGI:2442306",{"$nulls":3},"Unknown",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2020-07-10","Cryopreserved sperm",50,0,null,null,"true",null,"Wayne ","Crismani","St Vincent’s Institute of Medical Research ","wcrismani@svi.edu.au",{"$nulls":3},"Vanessa","Tsui","vtsui@svi.edu.au",null,null,"No"]
[9099,"B10.BR","B10.BR-H2<k2> H2-T18<a>/SgSnJ",null,"Semi-dominant",{"$nulls":28},"Histocompatibility 2, T region locus 18; a variant","H2-T18<a>",null,"Tla<a>","MGI:4820507",{"$nulls":3},"17",{"$nulls":3},"Yes","Yes","Unknown","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-11-25",{"$nulls":3},"ANU",null,"false",{"$nulls":8},"Viviane","Augusto","Viviane.augusto@anu.edu.au"]
[8622,"Zeb1 fl K5-creERt R26-YAP5SA","STOCK Zeb1<tm1.1Mpst> Gt(ROSA)26Sor<(CAGGS-Yap5SA,LacZ)Mao> Tg(KRT5-cre/ERT2)2Ipc",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",{"$nulls":3},"6",{"$nulls":16},"transgene insertion 2, I Pierre Chambon",{"$nulls":11},"Overexpression of activated YAP (NLS-YAP-5SA) with Keratin-5 (K5-CreERt) is sufficient to induce rapid formation of both SCC and spSCC in mice. spSCC tumours arise at sites of epithelial scratch wounding, where tumour-initiating epithelial cells undergo EMT to generate spSCC. Expression of the EMT transcription factor ZEB1 arises upon wounding and is a defining characteristic of spSCC in mice and humans. Thus, the wound healing response synergises with YAP to drive metaplastic transformation of SCC to spSCC.",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-12-18","Cryopreserved sperm",55,106,"ANU",null,"true",null,"Barry","Thompson","The Australian National University","barry.thompson@anu.edu.au",{"$nulls":8},"No"]
[8622,"Zeb1 fl K5-creERt R26-YAP5SA","STOCK Zeb1<tm1.1Mpst> Gt(ROSA)26Sor<(CAGGS-Yap5SA,LacZ)Mao> Tg(KRT5-cre/ERT2)2Ipc",null,"Recessive","zinc finger E-box binding homeobox 1","Zeb1","Unknown","3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a ","MGI:1344313","zinc finger E-box binding homeobox 1; targeted mutation 1.1, Marc Stemmler","Zeb1<tm1.1Mpst>","MGI:5901939","18"]
[8626,"Oleoyl-ACP H KO Line5","C57BL/6-Olah<em3>/5",null,"Recessive","oleoyl-ACP hydrolase","Olah","Unknown","E230009B14Rik, Thedc1","MGI:2139018",{"$nulls":3},"2",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-12-18","Cryopreserved sperm",40,0,null,null,"true",null,"Katherine","Kedzierska","Doherty Institute","kkedz@unimelb.edu.au",{"$nulls":8},"No"]
[9051,"Stock No: 000664","C57BL/6J","MGI:3028467","Recessive",{"$nulls":37},"This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.","C57BL/6J is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6J mice breed well, are long-lived, and have a low susceptibility to tumors. Primitive hematopoietic stem cells from C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J. This is a dominant trait. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) portosystemic shunts (~5%); 7) hairloss associated with overgrooming; 8) a preference for alcohol and morphine; 9) late-onset hearing loss; and 10) increased incidence of hydrocephalus and malocclusion.C57BL/6J mice fed a high-fat diet develop obesity, mild to moderate hyperglycemia, and hyperinsulinemia (see JAX® Diet-induced Obesity (DIO) Models). C57BL/6J mice fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat) for 14 weeks develop lesions in the range of 4500 to 8000 um2 atherosclerotic aortic lesions/aortic cross-section. The variation in aortic lesions found among various inbred strains has led to the identification of the existence of eight genes affecting atherosclerosis, Ath1 to Ath8. C57BL/6J mice also develop severe and progressive hearing loss later in life, with the disruption of both outer and inner hair cells, due to the Cdh23Ahl allele. Cheers and McKenzie found C57BL/6J resistant to listeriosis. A naturally occurring deletion in nicotinamide nucleotide transhydrogenase (Nnt) exons 7-11 occurred in C57BL/6J sometime prior to 1984. This deletion results in the absence of the NNT protein, and is associated with impaired glucose homeostasis control and reduced insulin secretion. This mutation is not found in C57BL/6JEi, C57BL/6N, C57BL/6NJ, C57BL/6ByJ, C57BL/10J, C57L/J, or C58/J (Toye AA, et al, Diabetologia, 2005). Since C57BL/6JEi separated from C57BL/6J in 1976, the Nnt deletion arose sometime between 1976 and 1984. Because of the n-Tr20m1J point mutation, which is also present in C57BL/6JEiJ but not C57BL/6NJ or C57BL/6ByJ, extracts from the cerebellum of C57BL/6J mice have increased ribosomal pausing at AGA codons compared with that of other inbred strains (Ishimura et al., 2014). Additionally, an intronic point deletion in Gabra2, which arose sometime between the early 1970's and 1990's, results in decreased transcript and protein expression of this chloride channel component in the brain.C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M (rs3709624) is T; 11-004367508-M (rs3659787) is G; 13-041017317-M (rs3722313) is T; 15-057561875-M (rs3702158) is A; 19-049914266-M (rs3724876) is G (Petkov and Wiles, 2004.) Others have subsequently identified further SNP differences between sublines of C57BL/6 (Mekada et al., 2009, Zurita et al., 2010). ","C57BL/6J ","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","35",null,null,"No","2020-08-05","Embryo",0,646,"ANU","C57BL/6J","false",null,"The Australian","Phenomics Facility","Australian Phenomics Facility","phenbank@anu.edu.au",{"$nulls":3},"Dominik","Spensberger","dominik.spensberger@anu.edu.au",null,null,"No"]
[8635,null,"Fut 7 KO line 2",null,"Semi-dominant","Fut 7 ","Fut 7",{"$nulls":6},"Unknown",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2019-01-15",null,0,0,null,null,"true",null,"Clare","Oates","Doherty Institute, Melbourne University","c.oates@unimelb.edu.au",{"$nulls":8},"No"]
[8645,"p60 KO","C57BL/6N-Katna1<tm1a(KOMP)Wtsi>/MarpApb",null,"Recessive","katanin p60 (ATPase-containing) subunit A1","Katna1","Nil","http://www.informatics.jax.org/marker/MGI:1344353","MGI:1344353","katanin p60 subunit A-like 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Katna1<tm1a(KOMP)Wtsi>","MGI:4458514","10",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6N","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-01-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[9102,"C57Bl/6-Mstn-/-","B6N.129-Mstn<tm1Sjl>",null,"Recessive","Myostatin","Mstn","Reduced","Gdf8","MGI:95691","Mstn<tm1Sjl>",null,"MGI:3790519","1",{"$nulls":19},"Myostatin","Mstn ",null,"Gdf8 ","95691",{"$nulls":3},"1","Hyperplasia and hypertrophy of muscle tissues.","Mild hyperplasia and hypertrophy of muscle tissues.","C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-11-26","Cryopreserved sperm",50,0,null,null,"false",null,"Gary","Anderson","University of Melbourne","gpa@unimelb.edu.au",{"$nulls":8},"No"]
[9098,"CD8 Cre","Tg(ECD-CACG-Cre)",null,"Semi-dominant","CD8 Cre",{"$nulls":7},"Unknown",{"$nulls":16},"CD8 Cre","CAGG","Unknown",{"$nulls":9},"Normal","Normal","C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-11-12","Cryopreserved sperm",50,0,null,null,"false",null,"Tin","Kyaw","Baker Heart and Diabetes Institute","tinsoe.kyaw@baker.edu.au",{"$nulls":8},"No"]
[9101,null,"B6.Abca12<Tm1c>;Tg(KRT14-cre/ERT)",null,"Semi-dominant","ATP-binding cassette, sub-family A (ABC1), member 12","Abca12","Reduced","4832428G11Rik, 4833417A11Rik ","MGI:2676312 ","ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1c","Abca12<tm1c>",null,"1",{"$nulls":16},"Transgene insertion 1","KRT14","Unknown",{"$nulls":9},"normal","normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-11-25","Cryopreserved sperm",50,0,null,null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[9111,"ASD538:Nfkb2<D865G>:Kenobi","C57BL/6JSfdAnu-Nfkb2<am1Anu>/AnuApb ",null,"Semi-dominant","Nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100","Nfkb2",null,"NF kappaB2, p52 ","MGI:1099800 ","Nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100","Nfkb2<m1ANU>",null,"19",{"$nulls":28},"Immune deficiency. Hypogammaglobulinemia. Absolutely no B cells or pre-B cells due to kenobi mutation.D865G mutation confers autoimmune disease.Mice develop organ-specific autoimmune disease due to poor T cell selection in the thymus. Mice lose body weight and become unwell between 150 and 200 days old due to major pancreatitis. Homozygous females struggle to feed their pups and so do not maintain litters well.","Heterozygous mice have a mild autoimmune disease phenotype.","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-12-04","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Matthew","Cook","Australian National Unviersity","matthew.cook@anu.edu.au",{"$nulls":8},"No"]
[9111,"ASD538:Nfkb2<D865G>:Kenobi","C57BL/6JSfdAnu-Nfkb2<am1Anu>/AnuApb ",null,"Semi-dominant","CD79A antigen (immunoglobulin-associated alpha)","Cd79a ",null,"Cd79a, Ig alpha, Ig-alpha, Iga, Ly54, mb-1 ","MGI:101774 ","CD79A antigen (immunoglobulin-associated alpha); mutation 1, The Australian National University ","Cd79<am1Anu>","MGI:5006856 ","7"]
[8652,"PKHD1 KO","C57BL/6-Pkhd1<em1Smy>/SmyMarp",null,"Recessive","polycystic kidney and hepatic disease 1","Pkhd1",null,"FPC, tigmin","MGI:2155808",{"$nulls":3},"1",{"$nulls":28},"unknown","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-02-05","Cryopreserved sperm",50,0,null,null,"true",null,"Ian","Smyth","Monash University","ian.smyth@monash.edu",{"$nulls":8},"No"]
[8653,"HRGKO","C57BL/6-Hrg<tm1>",null,"Recessive","histidine-rich glycoprotein","Hrg","Nil","D16JH2, D18020","MGI:2146636","HRG",null,null,"16",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-02-08","Cryopreserved sperm",50,0,null,null,"true",null,"Mark","Hulett","La Trobe Institute for Molecular Science","a.mayfosh@latrobe.edu.au",{"$nulls":8},"No"]
[8633,"Katnal2 Flox","C57BL/6N-Katnal2<tm1c(EUCOMM)Wtsi>/MarpApb",null,"Recessive","katanin p60 subunit A-like 2","Katnal2",null,"3110023G01Rik, 4933439B08Rik","MGI:1924234","katanin p60 subunit A-like 2; targeted mutation 1c, Wellcome Trust Sanger Institute","Katnal2<tm1c(EUCOMM)Wtsi>","MGI:6164199","18",{"$nulls":28},"Normal","Normal","C57/BL6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-01-10","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O\"Bryan","Monash University","moira.o'bryan@monash.edu",{"$nulls":8},"No"]
[8656,"LMR","B6.Cg-Msh2<tm1Ndw> Rag1<tm1Bal> Tg(IgkHyHEL10)1Rbr/Cjo",null,"Recessive","mutS homolog 2","Msh2",null,null,"MGI:101816",{"$nulls":3},"17",{"$nulls":16},"transgene insertion 1, Robert Brink",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-02-15","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Jolly","Centenary Institute","c.jolly@centenary.org.au",{"$nulls":8},"No"]
[8656,"LMR","B6.Cg-Msh2<tm1Ndw> Rag1<tm1Bal> Tg(IgkHyHEL10)1Rbr/Cjo",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, David Baltimore","Rag1<tm1Bal>","MGI:2448994","2"]
[8657,"P18.B6","C57BL/6JAusb-Ipo4<em1Cjo>/Cjo",null,"Recessive","importin 4","Ipo4",null,"8430408O15Rik","MGI:1923001",{"$nulls":3},"14",{"$nulls":28},"Unknown",null,"C57BL/6JAusb","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-15","Cryopreserved sperm",50,0,null,null,"true",null,"Chris","Jolly","Centenary Institute","c.jolly@centenary.org.au",{"$nulls":8},"No"]
[8658,"S25HR","B6(Cg)-Igh<tm1Rbr> Rag1<tm1Mom> Samhd1<em1Cjo>/Cjo",null,"Recessive","immunoglobulin heavy chain complex","Igh",null,null,"MGI:96442","immunoglobulin heavy chain complex; targeted mutation 1, Robert Brink","Igh<tm1Rbr>","MGI:3800383","12",{"$nulls":28},"Unknown",null,"C57BL/6JAusb","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-15","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Jolly","Centenary Institute","c.jolly@centenary.org.au",{"$nulls":8},"No"]
[8658,"S25HR","B6(Cg)-Igh<tm1Rbr> Rag1<tm1Mom> Samhd1<em1Cjo>/Cjo",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2"]
[8658,"S25HR","B6(Cg)-Igh<tm1Rbr> Rag1<tm1Mom> Samhd1<em1Cjo>/Cjo",null,"Recessive","SAM domain and HD domain, 1","Samhd1",null,"E330031J07Rik","MGI:1927468",{"$nulls":3},"2"]
[8659,"S41LR","B6(Cg)-Rag1<tm1Mom> Samhd1<em2Cjo> Tg(IgkHyHEL10)1Rbr/Cjo",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","recombination activating gene 1; targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":16},"transgene insertion 1, Robert Brink",{"$nulls":11},"Unknown",null,"C57BL/6JAusb","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-15","Cryopreserved sperm",50,0,null,null,"false",null,"Chris","Jolly","Centenary Institute","c.jolly@centenary.org.au",{"$nulls":8},"No"]
[8659,"S41LR","B6(Cg)-Rag1<tm1Mom> Samhd1<em2Cjo> Tg(IgkHyHEL10)1Rbr/Cjo",null,"Recessive","SAM domain and HD domain, 1","Samhd1",null,"E330031J07Rik","MGI:1927468",{"$nulls":3},"2"]
[9118,"Fancl-del336_337","C57BL/6J-Fancl<em1>/Richard Dandrea",null,"Semi-dominant","Fanconi anemia, complementation group L","Fancl",null,"2010322C19Rik, B230118H11Rik, gcd, Phf9, Pog ","MGI:1914280","endonuclease mediated targeting 1; Richard D'Andrea","Fancl-del336_337",null,"Unknown",{"$nulls":28},"Slightly smaller than wild type, microphtalmia in one or both eyes.","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-18","Cryopreserved sperm",50,0,null,null,"true",null,"Richard","Dandrea","University of South Australia","richard.dandrea@unisa.edu.au",{"$nulls":8},"No"]
[9117,"Coro2a","C57BL/6-Coro2a<tm1(KOMP)Wtsi>",null,"Semi-dominant","coronin, actin binding protein 2A","Coro2a",null,"9030208C03Rik, coronin 4, IR10 ","MGI:1345966","Coro2a targeted mutation 1 (KOMP)","Coro2a<tm1(KOMP)Wtsi>",null,"4",{"$nulls":28},"Minor alterations in T cell development, but essentially wildtype","Wildtype","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-11","Cryopreserved sperm",50,0,null,null,"false",null,"Mark","Chong","St Vincent's Institute of Medical Research","mchong@svi.edu.au",{"$nulls":8},"No"]
[8664,"C169 (Gabrg2 PM)","C57BL/6J-Gabrg2<em1Mgmp>/Mgmp",null,"Recessive","gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2","Gabrg2",null,"GABAA-R, Gabrg-2, gamma2","MGI:95623",{"$nulls":3},"11",{"$nulls":28},"Unknown","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-26","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Michael","Bowen","The University of Sydney","michael.bowen@sydney.edu.au",{"$nulls":8},"No"]
[9130,"Kcnt1 P905L","C57BL/6-Kcnt1 <em1P905L>",null,"Semi-dominant","potassium channel, subfamily T, member 1","Kcnt1 ",null,"C030030G16Rik, Slack, slo2","MGI:1924627 ","potassium channel, subfamily T, member 1 P905L","Kcnt1 <em1P905L>",null,"2",{"$nulls":28},"Mice have spontaneous seizure and early mortality","Normal","C57Bl6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-20","Cryopreserved sperm",50,0,null,null,"true",null,"Lynley","Cordeiro",null,"lynley.cordeiro@florey.edu.au",{"$nulls":8},"No"]
[9131,"Kcnt1 KO","C57BL/6 - Kcnt1",null,"Semi-dominant","potassium channel, subfamily T, member 1","Kcnt1","Unknown","C030030G16Rik, Slack, slo2","MGI:1924627",{"$nulls":3},"2",{"$nulls":28},"Normal","Normal","C57Bl6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-20","Cryopreserved sperm",50,0,null,null,"true",null,"Lynley","Cordeiro",null,"lynley.cordeiro@florey.edu.au",{"$nulls":8},"No"]
[9135,"ENU47:092:Ikbkb","C57BL/6Ncrl<ENU47>/ApbAnu",null,"Semi-dominant","inhibitor of kappaB kinase beta","Ikbkb ",null,"IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta ","MGI:1338071",{"$nulls":3},"8",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-23","Cryopreserved sperm",55,0,null,null,"true",null,"Anna","Palkova","APF","anna.palkova@anu.edu.au",{"$nulls":8},"No"]
[8661,"Nmnat2 knockout","C57BL/6J-Nmnat2<em1Dunw>/Dunw",null,"Recessive","nicotinamide nucleotide adenylyltransferase 2","Nmnat2",null,"D030041I09Rik, mKIAA0479, PNAT1","MGI:2444155",{"$nulls":3},"1",{"$nulls":28},"Perinatal lethality, neuromuscular malformations,lack of functional organ and muscle innervation, distended bladder","Normal","C57BL/6J","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-02-25","Cryopreserved sperm",40,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":8},"No"]
[8662,"CCDC112KO","C57BL/6J-Ccdc112<em1Mkob>/MkobMarp",null,"Recessive","coiled-coil domain containing 112","Ccdc112",null,"8430438M01Rik","MGI:1918800",{"$nulls":3},"18",{"$nulls":28},"Males are infertile, females are normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2019-02-26","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8667,"Haao knockout","C57BL/6J-Haao<em1Dunw>/Dunw",null,"Recessive","3-hydroxyanthranilate 3,4-dioxygenase","Haao",null,"0610007K21Rik, 0610012J07Rik, 3HAO, 3-HAO, 3-HAOxase","MGI:1349444",{"$nulls":3},"17",{"$nulls":28},"Mice homozygous for a knock-out allele exhibit reduced LPS-induced depressive behaviors and altered kynurenine metabolism.","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-02-28","Cryopreserved sperm",50,0,"Victor Chang",null,"true",null,"Sally","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":8},"No"]
[8674,null,"ASD981:Pecan:15::N1 ",null,"Recessive","Ku70cKO",{"$nulls":7},"Unknown",{"$nulls":28},"Unknown","Unknown","Charles River B6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-03-07","Cryopreserved sperm",6,0,"ANU","981","true",null,"Nikki","Ross","Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[8675,"Fcho2","C57BL/6NCrlAnu-Fcho2<em1Anu>/AnuApb",null,"Recessive","FCH domain only 2","Fcho2","Unknown","5832424M12Rik","MGI:3505790",{"$nulls":3},"13",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-03-12","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[7589,null,"C57BL/6-Grb10-global",null,"Dominant","growth factor receptor bound protein 10","Grb10","Reduced","5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207","MGI:103232",null,"Grb10Δ",null,"11",{"$nulls":28},"Homozygotes are rare. If produced, they have the phenotype of being very large at birth","Paternal heterozygotes - normalMaternal heterozygotes - large during embryogenesis and large at birth","C57BL/6","Unknown","No","Yes","Unknown","Unknown","Yes","No","Good",null,null,"paternal heterozygotes x WT to be used for breeding","No","2014-02-14","Cryopreserved sperm",50,0,"ABR - Moss Vale",null,"false",null,"Roger","Daly","Monash University","roger.daly@monash.edu",{"$nulls":3},"Lowenna","Holt","lowennaholt@gmail.com","10/39","TBC","No"]
[6417,"GRB7Δ","B6.CBA-Grb7<tm1>/Ausb",null,"Recessive","growth factor receptor bound protein 7","Grb7","Unknown",null,"MGI:102683",{"$nulls":3},"11",{"$nulls":28},"Cell metastasis",null,"C57BL/6 x CBA","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2011-09-13","Embryo",0,0,"Moss Vale","2053","false",null,"Roger","Daly","Monash University","roger.daly@monash.edu",{"$nulls":6},"N/A","N/A","No"]
[6416,"G14Δ","B6.129SV-Grb14<tm1Daly>/Ausb",null,"Dominant","growth factor receptor bound protein 14","Grb14","Normal",null,"MGI:1355324","growth factor receptor bound protein 14; targeted mutation 1, Roger J Daly","Grb14<tm1Daly>","MGI:3029164","2",{"$nulls":28},"Improved glucose tolerance:*Males exhibit increased glucose tolerance between 16 and 24 weeks of age.*Circulating level of insulin is lower in males in response to the same glucose load.*Males exhibit an increase in glucose incorporation into tissue glycogen.Increased insulin sensitivity:*Decrease in blood glucose than wild-type males.*Fasting plasma insulin levels in males are lower at 28-30 and 54-56 weeks of age.*Male skeletal muscle and liver exhibits enhanced insulin-induced glucose uptake.Increased heart weight:*28 week old males exhibit an 18% increase in heart weight.Decreased body weight:*Small but significant decrease in body weight for both males (5-10%) and females (5%).Decreased spleen weight:*28 week old males exhibit a disproportionate decrease (29%) in spleen weight.Decreased liver weight:*28 week old males exhibit a disproportionate decrease (16%) in liver weight.",null,"B6/129SV","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","11","false",null,"Roger","Daly","Monash University","roger.daly@monash.edu",{"$nulls":3},"Jenny","Kingham","j.kingham@garvan.org.au","N/A","N/A","No"]
[7697,"IFNe 202 flp<#65>(FF)","C57BL/6-Ifne<tm1.1Pjh>/MarpApb",null,"Recessive","Interferon epsilon","Ifne","Normal","Ifne1, Ifnt1 ","MGI:2667156","interferon epsilon; targeted mutation 1.1, Paul J Hertzog","Ifne<tm1.1Pjh>","MGI:5503221","4",{"$nulls":28},"Normal wild-type","Normal wild-type","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2014-06-12","Cryopreserved sperm",48,0,"Monash",null,"false",null,"Kelly","Rodwell","MIMR-PHI Institute of Medical Research","kelly.rodwell@monash.edu",{"$nulls":3},"Kelly ","Rodwell","kelly.rodwell@monash.edu","MMCA/2008/25 BC","PC1-N22-14","No"]
[8689,"Cish wt/wt","BALB/c-Cish<wt>/",null,"Dominant","cytokine inducible SH2-containing protein","Cish",null,"Cis, CIS1, cytokine-inducible SH2 protein, F23","MGI:103159",{"$nulls":3},"9",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[6414,"G10Δ","B6.CBA-Grb10<Gt(Betageo)1Ward>/Ausb",null,"Recessive","growth factor receptor bound protein 10","Grb10","Nil","5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207","MGI:103232","growth factor receptor bound protein 10; gene trap 1, Andrew Ward","Grb10<Gt(Betageo)1Ward>","MGI:2668436","11",{"$nulls":28},"Enlarged placenta:*The size of the placenta was also increased ~30% relative to wild-type.Increased birth body size:*Neonates are ~30% larger than wild-type.Increased fetal size:*Embryonic overgrowth resulting in neonates that are ~30% larger than wild-type.Enlarged liver:*Disproportionate overgrowth of the liver.","Partial perinatal lethality:*Approximately 12% of mice with a maternally inherited allele die shortly after birth.Paternal imprinting:*Only heterozygotes inheriting the allele from the mother display a phenotype.Enlarged placenta:*The size of the placenta is increased ~30% relative to wild-type.Increased birth body size:*Neonates are ~30% larger than wild-type.Increased fetal size:*Embryonic overgrowth resulting in neonates that are ~30% larger than wild-type.Enlarged liver:Disproportionate overgrowth of the liver.Increased glycogen level:*Hepatocytes have a very high glycogen content.Abnormal pulmonary alveolus morphology:*Mice that die shortly after birth exhibit blood-filled alveoli.Abnormal trachea morphology:*Mice that die shortly after birth exhibit a blood-filled trachea.","CBA/B6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-09-13",null,0,0,"Moss Vale","16","false",null,"Roger","Daly","Monash University","roger.daly@monash.edu",{"$nulls":3},"Jenny","Kingham","enquires@abr.org.au","N/A","N/A","No"]
[819,"Grb10 KO x  Grb14 KO","C57BL/6-Grb10<Gt(Betageo)1Ward> Grb14<tm1Daly>",null,"Recessive","growth factor receptor bound protein 10","Grb10","Nil","5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207","MGI:103232","gene trap 1, Andrew Ward","Grb10<Gt(Betageo)1Ward>","MGI:2668436","11",{"$nulls":15},"Yes",{"$nulls":12},"Double KOs do not show increased insulin signalling over single KOs.Compound KOs exhibit an increase in lean mass.Compound KOs are protected from impaired glucose tolerance that results from high-fat diet whereas sible KOs are not protected.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-05-21",null,0,0,null,null,"false",null,"Roger","Daly","Monash University","roger.daly@monash.edu",{"$nulls":3},"Roger","Daly","roger.daly@monash.edu","N/A","N/A","No"]
[819,"Grb10 KO x  Grb14 KO","C57BL/6-Grb10<Gt(Betageo)1Ward> Grb14<tm1Daly>",null,"Recessive","growth factor receptor bound protein 14","Grb14","Nil",null,"MGI:1355324","targeted mutation 1, Roger J Daly","Grb14<tm1Daly>","MGI:3029164","2",{"$nulls":58},"Roger","Daly","roger.daly@monash.edu","N/A","N/A"]
[9155,"ASD1073:Wombok","C57BL/6NCrlAnu-Zc3h12b<em1Anu>/AnuApb",null,"Semi-dominant","P377L","Zc3h12b","Unknown","A130028J20Rik, LOC245523","MGI:2442133 ","P377L","C57BL/6NCrlAnu-Zc3h12b<P377L>/AnuApb",null,"X",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-03-09","Cryopreserved sperm",69,0,"ANU",null,"true",null,"Anselm","Enders","Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[9156,"Irf4 K59R; Kale","C57BL/6NCrlAnu-Irf4<em7Anu>/Anu",null,"Dominant","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip ","MGI:1096873","endonuclease mediated targeting 7; Anselm Enders","Irf4<K59R>","Kale","13",{"$nulls":28},"unknown","reduced B1a cells","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-03-09","Cryopreserved sperm",36,0,null,null,"true",null,"Anselm","Enders",null,"anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[8692,"C57/Bl6 Cish-lacZ/lacZ","C57BL/6-Cish<tm1>/",null,"Recessive","cytokine inducible SH2-containing protein","Cish",null,"Cis, CIS1, cytokine-inducible SH2 protein, F23","MGI:103159","lacZ",null,null,"9",{"$nulls":28},"Disrupted haematopoiesis and metabolism","Normal","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[8693,"C57/Bl6 Gmcsf-/- Cish-wt-wt","C57BL/6-Csf2<tm1Ard> Cish<wt>/",null,"Recessive","colony stimulating factor 2 (granulocyte-macrophage)","Csf2",null,"Csfgm, Gm-CSf, GMCSF, MGI-IGM","MGI:1339752","colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Ashley R Dunn","Csf2<tm1Ard>","MGI:1930997","11",{"$nulls":28},"Altered macrophage biology","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[8690,"Balb/c Cish-lacZ/lacZ","BALB/c-Cish<tm1>/",null,"Recessive","cytokine inducible SH2-containing protein","Cish",null,"Cis, CIS1, cytokine-inducible SH2 protein, F23","MGI:103159","lacZ",null,null,"9",{"$nulls":28},"Disrupted haematopoiesis and metabolism","Normal","BALB/c","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[8691,"C57/Bl6 Cish-wt/wt","C57BL/6-Cish<wt>/",null,"Dominant","cytokine inducible SH2-containing protein","Cish",null,"Cis, CIS1, cytokine-inducible SH2 protein, F23","MGI:103159","wt (wild-type)",null,null,"9",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-11",null,0,0,null,null,"true",null,"Alister","Ward","Deakin University","award@deakin.edu.au",{"$nulls":8},"No"]
[8669,"CBE1-5","C57BL/6-Cbe1<em1Marp>/MarpMob",null,"Recessive","RIKEN cDNA 1110017D15 gene","1110017D15Rik","Unknown","Cbe1, Smrp1","MGI:1920971",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-03-01","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8679,"C2KO-8B","C57BL/6-C2<em1>/8b",null,"Recessive","omplement component 2 (within H-2S)","C2","Nil","classical-complement pathway C3/C5 convertase","MGI:88226",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal ","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-03-26","Cryopreserved sperm",50,0,null,null,"true",null,"Anabel","Silva","CSL ltd","anabel.silva@csl.com.au",{"$nulls":8},"No"]
[8683,null,"C57BL/6NCrlAnu-Ikbkb<em2Anu>/1AnuApb",null,"Recessive","inhibitor of kappaB kinase beta","Ikbkb",null,"IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta","MGI:1338071",{"$nulls":3},"8",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-03","Cryopreserved sperm",60,0,"ANU",null,"true",null,"Chelisa","Cardinez","Australian National University","chelisa.cardinez@anu.edu.au",{"$nulls":8},"No"]
[8685,"IL2Rg del","C57BL/6-Il2rg<em1>/Csl",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg",null,"CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gammaC, gamma C receptor, gc, [g]c","MGI:96551",{"$nulls":3},"X",{"$nulls":28},"Impaired response to polyclonal T cell activators, deficits in their helper function, and a reduction in natural killer cell activity","Unknown",null,"Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-04","Cryopreserved sperm",50,0,null,null,"true",null,"Julie","Pasquet","CSL ltd","julie.pasquet@csl.com.au",{"$nulls":8},"No"]
[8686,"Rag2 del 15A","C57BL/6-Rag2<em1Csl>/15ACsl",null,"Recessive","recombination activating gene 2","Rag2",null,"Rag-2","MGI:97849",{"$nulls":3},"2",{"$nulls":28},"Fail to generate mature T or B lymphocytes.",null,null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-04","Cryopreserved sperm",40,0,null,null,"true",null,"Julie","Pasquet","CSL ltd","julie.pasquet@csl.com.au",{"$nulls":8},"No"]
[8699,"INHBB","C57BL/6-Inhbb<em1Mkob>/Marp",null,"Recessive","inhibin beta-B","Inhbb",null,"activin beta-B","MGI:96571",{"$nulls":3},"1",{"$nulls":28},"Sub-fertile","Normal","C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8701,"Cep76KO","C57BL/6J-Cep76<em1Mkob>/MkobMarp",null,"Recessive","centrosomal protein 76","Cep76",null,"6230425F05Rik","MGI:1923401",{"$nulls":3},"18",{"$nulls":28},"Sub-fertile male","Normal","C57BL/6J","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8700,"SCRN1KO","C57BL/6J-Scrn1<em1Mkob>/MkobMarp",null,"Recessive","secernin 1","Scrn1",null,"2810019K23Rik, 6330535A03Rik, mKIAA0193, SES1","MGI:1917188",{"$nulls":3},"6",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8697,"Katnb1KO","C57BL/6N-Katnb1<tm1a9EUCOMM)Hmgu>/Marp",null,"Recessive","katanin p80 (WD40-containing) subunit B 1","Katnb1",null,"2410003J24Rik, KAT","MGI:1921437","katanin p80 (WD40-containing) subunit B 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Katnb1<tm1a(EUCOMM)Hmgu>","MGI:4436305","8",{"$nulls":28},"Embryonic lethal","Normal","C57BL/6N","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8698,"Katbn1 flox","C57BL/6N-Katnb1<tm1c(EUCOMM)Hmgu>/Marp",null,"Recessive","katanin p80 (WD40-containing) subunit B 1","Katnb1",null,"2410003J24Rik, KAT","MGI:1921437","katanin p80 (WD40-containing) subunit B 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH","Katnb1<tm1c(EUCOMM)Hmgu>",null,"8",{"$nulls":28},"Normal","Normal","C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-15","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8710,"Fut7 KO (line 2) ","C57BL/6-Fut7<em1>/Apb",null,"Recessive","fucosyltransferase 7","Fut7","Unknown","FTVII, Fuc-TVII, FucT-VII","MGI:107692",{"$nulls":3},"2",{"$nulls":28},"Unknown. These mice have a defect in immune cell migration, which may make them more susceptible to infections. Regular monitoring is important to establish phenotype of these CRISPR mice. ","Unknown. These mice have a defect in immune cell migration, which may make them more susceptible to infections. Regular monitoring is important to establish phenotype of these CRISPR mice. ","C57BL/6","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-05-06","Cryopreserved sperm",40,0,null,null,"true",null,"Andrew","Brooks","Peter Doherty Institute for Infection and Immunity","agbrooks@unimelb.edu.au",{"$nulls":8},"No"]
[9171,"Rpl41:F0:19","C57BL/6NCrlAnu-Rpl41<em1Anu>/AnuApb",null,"Semi-dominant","ribosomal protein L41","Rpl41",null,"1810055P16Rik, 2210411K19Rik ","MGI:1915195","Rpl41<em1(APF)PTF>","Rpl41:F0:19",null,"10",{"$nulls":28},"unknown ","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-04-07","Cryopreserved sperm",12,0,"ANU",null,"true",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":3},"Rachel","Milne","rachel.milne@anu.edu.au",null,null,"No"]
[8696,"C2 (line 8B) ko","C57BL/6-C2<em1>/Apb",null,"Recessive","complement component 2 (within H-2S)","C2","Nil","classical-complement pathway C3/C5 convertase","MGI:88226",{"$nulls":3},"17",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-04-12",null,0,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8707,"Katnal2 KO","C57BL/6N-Katnal2<tm1a(EUCOMM)Wtsi>/MarpApb",null,"Recessive","katanin p60 subunit A-like 2","Katnal2","Nil","3110023G01Rik, 4933439B08Rik","MGI:1924234","katanin p60 subunit A-like 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Katnal2<tm1a(EUCOMM)Wtsi>","MGI:4842422","18",{"$nulls":28},"Male homozygous mice are infertile","Normal","C57BL/6N","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2019-05-06","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8712,"Tube1 Flox","C57BL/6J-Tube1<tm1>/MarpApb",null,"Recessive","epsilon-tubulin 1","Tube1","Unknown","2310061K05Rik","MGI:1919174","Tube1 Flox",null,null,"10",{"$nulls":28},"Normal","Normal","C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-05-06","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.o'bryan@monash.edu",{"$nulls":8},"No"]
[8716,"Wbp11","C57BL/6-Wbp11<em1Dunw>/DunwApb",null,"Recessive","WW domain binding protein 11","Wbp11",null,"2510026P17Rik, D6Wsu113e, Npwbp, SIPP1","MGI:1891823","Wbp11<em1Dunw>",null,null,"6",{"$nulls":28},"Embryonic lethal","Multiple congenital defectsPartial lethality","FVB x C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-05-14","Cryopreserved sperm",50,0,null,null,"true",null,"Sally ","Dunwoodie","Victor Chang Cardiac Research Institute","s.dunwoodie@victorchang.edu.au",{"$nulls":8},"No"]
[7890,"Ets1f/fxLysMCre","B6.Cg-Ets1<fl> Lyz2<tm1(cre)Ifo>/Marp",null,"Dominant","E26 avian leukemia oncogene 1","Ets1",null,"Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1","MGI:95455","Ets 1 floxed","Ets1<f/f>",null,"9",{"$nulls":28},"Normal but conditionally gives a macrophage specific knockout.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2015-05-11","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Kelly","Rodwell","MIMR-PHI Institute of Medical Research","kelly.rodwell@monash.edu",{"$nulls":3},"Kelly","Rodwell","kelly.rodwell@monash.edu","MMCA/2008/25 BC","PC1-N22-14","No"]
[7890,"Ets1f/fxLysMCre","B6.Cg-Ets1<fl> Lyz2<tm1(cre)Ifo>/Marp",null,"Dominant","lysozyme 2","Lyz2 ",null,"Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp","MGI:96897","Lysozyme 2; targeted mutation 1, Irmgard Forster","Lyz2<tm1(cre)Ifo>","MGI:1934631","10",{"$nulls":58},"Kelly","Rodwell","kelly.rodwell@monash.edu","MMCA/2008/25 BC","PC1-N22-14"]
[8798,"dKO Il2Rg RAg2","BALB/c-Il2rg<tm1> Rag2<em1Csl>/CslApb",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg",null,"D132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gammaC, gamma C receptor, gc, [g]c","MGI:96551",{"$nulls":3},"X",{"$nulls":28},"Normal","Normal","BALB/c","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-10-04","Cryopreserved sperm",40,340,null,null,"true",null,"Julie","Pasquet","CSL Limited","julie.pasquet@csl.com.au",{"$nulls":8},"No"]
[8798,"dKO Il2Rg RAg2","BALB/c-Il2rg<tm1> Rag2<em1Csl>/CslApb",null,"Recessive","recombination activating gene 2","Rag2",null,"Rag-2","MGI:97849",{"$nulls":3},"2"]
[4951,"Ifne<f/f>","C57BL/6-Ifne<tm1Phe>",null,"Recessive","interferon epsilon","Ifne",null,"Ifne1, Ifnt1","MGI:2667156",{"$nulls":3},"4",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-12-10",null,0,0,null,null,"false",null,"Paul","Hertzog","Monash University","Paul.Hertzog@med.monash.edu.au",{"$nulls":3},"Paul","Hertzog","paul.hertzog@med.monash.edu.au","A2006/15","2008-1013","No"]
[9175,"Vcp fl/fl","C57BL/6J-Vcp<em1Wei>/APF",null,"Semi-dominant","valosin containing protein","Vcp ",null,"AAA ATPase p97, CDC48, p97, p97/VCP ","MGI:99919","valosin containing protein","Vcp ",null,"4",{"$nulls":28},"Knockout muscle demonstrated a necrotic myopathy with increased macroautophagic/autophagic proteins and damaged lysosomes","Unknown","C57BL/6N APB","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-04-23",null,0,0,"ANU",null,"false",null,"Si Ming","Man","JCSMR","Siming.man@anu.edu.au",{"$nulls":3},"Si Ming","Man","Siming.man@anu.edu.au",null,null,"No"]
[8722,"ASD783:Man2a1:1bp ins","C57BL/6NCrlAnu-Man2a1<m1Anu>/AnuApb",null,"Recessive","mannosidase 2, alpha 1","Man2a1",null,"Mana2, Mana-2, Map-2","MGI:104669",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-05-31","Cryopreserved sperm",48,0,"ANU","783","true",null,"Julia","Ellyard","Australian National University","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[8724,"Adar1E861A/E861A Ifih1-/- Adar2-/- Gria2R/R","B6.129-Adar<tm1.1Xen> Adarb1<tm1PhS> Gria2<tm1Phs> Ifih1<tm1.1Cln>/StVApb",null,"Recessive","adenosine deaminase, RNA-specific","Adar",null,"ADAR1, Adar1p110, Adar1p150, mZaADAR","MGI:1889575","adenosine deaminase, RNA-specific; targeted mutation 1.1, Taconic Biosciences","Adar<tm1.1Xen>","MGI:5805648","3",{"$nulls":28},"Compound homozygous animals are normal","Compound heterozygous animals are normal. Note all Adar2-/-Gria2R/+ and Adar2-/-Gria2+/+ die shortly after birth independent of the Adar1/Ifih1 genotypes","C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-04","Cryopreserved sperm",40,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[8724,"Adar1E861A/E861A Ifih1-/- Adar2-/- Gria2R/R","B6.129-Adar<tm1.1Xen> Adarb1<tm1PhS> Gria2<tm1Phs> Ifih1<tm1.1Cln>/StVApb",null,"Recessive","adenosine deaminase, RNA-specific, B1","Adarb1",null,"1700057H01Rik, ADAR2, D10Bwg0447e, RED1","MGI:891999","adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg","Adarb1<tm1Phs>","MGI:2178079","10"]
[8724,"Adar1E861A/E861A Ifih1-/- Adar2-/- Gria2R/R","B6.129-Adar<tm1.1Xen> Adarb1<tm1PhS> Gria2<tm1Phs> Ifih1<tm1.1Cln>/StVApb",null,"Recessive","glutamate receptor, ionotropic, AMPA2 (alpha 2)","Gria2","Reduced","GluA2, Glur2, Glur-2, GluR2, GluR-B","MGI:95809","glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, Peter H Seeburg","Gria2<tm1Phs>","MGI:2178124","3"]
[8724,"Adar1E861A/E861A Ifih1-/- Adar2-/- Gria2R/R","B6.129-Adar<tm1.1Xen> Adarb1<tm1PhS> Gria2<tm1Phs> Ifih1<tm1.1Cln>/StVApb",null,"Recessive","interferon induced with helicase C domain 1","Ifih1",null,"9130009C22Rik, Helicard, MDA5, MDA-5","MGI:1918836","interferon induced with helicase C domain 1; targeted mutation 1.1, Marco Colonna","Ifih1<tm1.1Cln>","MGI:3663677","2"]
[8726,"NR.Triple427.huPI","NOD.129S7B6-Rag1<tm1Mom> H2<d1Ab1Ea2> Ins1<em1(INS)Tkay> Tg(hCD4) Tg(HLA-DR4, HLA-DQ8)/Tkay",null,"Recessive","insulin I","Ins1",null,null,"MGI:96572","INS knockin","em1(INS)Tkay",null,"19",{"$nulls":16},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells",{"$nulls":9},"Normal","Normal","NOD.129S7.B6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-06","Cryopreserved sperm",50,0,"St V",null,"true",null,"Stuart","Mannering","St Vincent's Institute","smannering@svi.edu.au",{"$nulls":8},"No"]
[8726,"NR.Triple427.huPI","NOD.129S7B6-Rag1<tm1Mom> H2<d1Ab1Ea2> Ins1<em1(INS)Tkay> Tg(hCD4) Tg(HLA-DR4, HLA-DQ8)/Tkay",null,"Recessive","recombination activating gene 1","Rag1",null,"Rag-1","MGI:97848","targeted mutation 1, Peter Mombaerts","Rag1<tm1Mom>","MGI:1857241","2",{"$nulls":16},"human leukocyte antigen class II"]
[8726,"NR.Triple427.huPI","NOD.129S7B6-Rag1<tm1Mom> H2<d1Ab1Ea2> Ins1<em1(INS)Tkay> Tg(hCD4) Tg(HLA-DR4, HLA-DQ8)/Tkay",null,"Recessive","histocompatibility-2, MHC","H2",null,"H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17"]
[8291,"NSG.DQ8.HuPI","NOD.Cg-Prkdc<scid> H2-Ab1<tm1Gru> Il2rg<tm1Wjl> Ins1<em1(INS)Tkay> Tg(HLA-DQA1,HLA-DQB1)1Dv ",null,"Recessive","protein kinase, DNA activated, catalytic polypeptide","Prkdc","Unknown","DNAPDcs, DNA-PK, DNA-PKcs, DOXNPH, dxnph, slip, XRCC7","MGI:104779","protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency","Prkdc<scid>","MGI:1857113","16",{"$nulls":16},"transgene insertion 1, Chella David",{"$nulls":11},"Immunocompromised.Expresses HLA-DQ8 and human insulin.","Immunocompromised.Expresses HLA-DQ8 and human insulin.","NOD (NSG)","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2017-08-22","Cryopreserved sperm",50,0,"St V",null,"true",null,"Stuart","Mannering","St Vincent's Institute","smannering@svi.edu.au",{"$nulls":8},"No"]
[8291,"NSG.DQ8.HuPI","NOD.Cg-Prkdc<scid> H2-Ab1<tm1Gru> Il2rg<tm1Wjl> Ins1<em1(INS)Tkay> Tg(HLA-DQA1,HLA-DQB1)1Dv ",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Nil","Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-Ab, I-Abeta, Rmcs1","MGI:103070","histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Michael J Grusby","H2-Ab1<tm1Gru>","MGI:2158420","17"]
[8291,"NSG.DQ8.HuPI","NOD.Cg-Prkdc<scid> H2-Ab1<tm1Gru> Il2rg<tm1Wjl> Ins1<em1(INS)Tkay> Tg(HLA-DQA1,HLA-DQB1)1Dv ",null,"Recessive","interleukin 2 receptor, gamma chain","Il2rg","Nil","CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gammaC, gamma C receptor, gc, [g]c","MGI:96551","interleukin 2 receptor, gamma chain; targeted mutation 1, Warren J Leonard","Il2rg<tm1Wjl>","MGI:1857455","X"]
[8291,"NSG.DQ8.HuPI","NOD.Cg-Prkdc<scid> H2-Ab1<tm1Gru> Il2rg<tm1Wjl> Ins1<em1(INS)Tkay> Tg(HLA-DQA1,HLA-DQB1)1Dv ",null,"Recessive","insulin I","Ins1","Nil",null,"MGI:96572",{"$nulls":3},"19"]
[8730,null,"ASD852:Tempeh",null,"Recessive",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2019-06-12","Cryopreserved sperm",11,0,"ANU",null,"true",null,"Nikki","Ross","Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[5455,"ENU13NIH:069b","C57BL/6JAnu-Pax5<m1Anu>/AnuApb","C57BL/6JAnu-Pax5<m1Anu>/AnuApb","Recessive","paired box gene 5","Pax5","Reduced","EBB-1, Pax-5","MGI:97489","paired box gene 5; mutation 1, The Australian National University","Pax5<m1Anu>","MGI:5563444","4","ENSMUSG00000014030","ENSMUST00000014174","Pax5-001","1053","1307","T to A","ENSMUSE00000660796","9","351","Tyrosine to STOP",{"$nulls":4},"TCTGGAAGTCCCTACAGCCACCCTCAGTATTCTTCCTACAATGATTCTTGGAGGTTCCCCA","Yes",{"$nulls":12},"No B cells.Small and sick looking.",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2011-03-07","Cryopreserved sperm",79,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":3},"Bhavani","Balakishnan","bhavani.balakishnan@anu.edu.au","J.APF.14.08","N/A","No"]
[9178,"Arap2 F0:19","C57BL/6NCrlAnu-Arap2<em3>/AnuApb",null,"Semi-dominant","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2","Arap2",null,"Centd1, mKIAA0580","MGI:2684416 ","endonuclease mediated targeting 3;","Arap2 F0:19",null,"Unknown",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-05-07","Cryopreserved sperm",11,0,null,null,"true",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":8},"No"]
[8708,"Katnal2 KO x Katna1 Flox","C57BL/6N-Katna1<tm1c(KOMP)Wtsi> Katnal2<tm1a(EUCOMM)>/MarpApb",null,"Recessive","katanin p60 (ATPase-containing) subunit A1","Katna1",null,null,"MGI:1344353","katanin p60 (ATPase-containing) subunit A1; targeted mutation 1a, Wellcome Trust Sanger Institute","Katna1<tm1a(KOMP)Wtsi>","MGI:4458514","10",{"$nulls":28},"Male infertile","Normal","C57BL/6N","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2019-05-06","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8708,"Katnal2 KO x Katna1 Flox","C57BL/6N-Katna1<tm1c(KOMP)Wtsi> Katnal2<tm1a(EUCOMM)>/MarpApb",null,"Recessive","katanin p60 subunit A-like 2","Katnal2",null,"3110023G01Rik, 4933439B08Rik","MGI:1924234","katanin p60 subunit A-like 2; targeted mutation 1a, Wellcome Trust Sanger Institute","Katnal2<tm1a(EUCOMM)Wtsi>","MGI:4842422","18"]
[8727,"ENU43:270:Nr4a3","C57BL/6NCrlAnu-Nr4a3<m1Anu>/AnuApb",null,"Recessive","nuclear receptor subfamily 4, group A, member 3","Nr4a3",null,"MINOR, Nor1, NOR-1, TEC","MGI:1352457",{"$nulls":3},"4",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-09","Cryopreserved sperm",24,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":3},"Anna","Palkova","apf.scientific.programs@anu.edu.au",null,null,"No"]
[8728,"ENU43:375:Nr4a3","C57BL/6NCrlAnu-Nr4a3<m1Anu>/AnuApb",null,"Recessive","nuclear receptor subfamily 4, group A, member 3","Nr4a3",null,"MINOR, Nor1, NOR-1, TEC","MGI:1352457",{"$nulls":3},"4",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-09","Cryopreserved sperm",66,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8729,"ENU43:395:Nr4a3","C57BL/6NCrlAnu-Nr4a3<m1Anu>/AnuApb",null,"Recessive","nuclear receptor subfamily 4, group A, member 3","Nr4a3",null,"MINOR, Nor1, NOR-1, TEC","MGI:1352457",{"$nulls":3},"4",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-09","Cryopreserved sperm",12,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8733,"ENU31:075:Irf2","C57BL/6NCrlAnu-Irf2<m1Anu>/AnuApb",null,"Recessive","interferon regulatory factor 2","Irf2",null,"9830146E22Rik, Irf-2","MGI:96591",{"$nulls":3},"8",{"$nulls":30},"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-17","Cryopreserved sperm",72,0,"ANU",null,"true",null,"Anna","Palkova","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8734,"Swiss:TOP UP ONLY","Swiss Webster Outbred:TOP UP ONLY",null,"Dominant",{"$nulls":37},"Normal.High fecundity, excellent mothers, ideal for recipients.",null,"Swiss Webster","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-06-19",null,0,289,"ANU",null,"true",null,"Holly","Burke","Australian National University","animal.shipments@anu.edu.au",{"$nulls":8},"No"]
[8736,null,"ASD1005:Polenta",null,"Recessive",{"$nulls":40},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2019-06-19","Cryopreserved sperm",11,0,"ANU",null,"true",null,"Jenna","Lowe","Australian National University","jenna.lowe@anu.edu.au",{"$nulls":8},"No"]
[8745,"ASD873:Pear:XB151","C57BL/6NCrlAnu-Xbp1<em1Anu>/AnuApb",null,"Recessive","X-box binding protein 1","Xbp1",null,"D11Ertd39e, TREB5, TREB-5, XBP-1","MGI:98970",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-02","Cryopreserved sperm",44,0,"ANU",null,"true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[9188,"Drosha","B6.129P2-Drosha<tm1Litt>/AnuApb",null,"Recessive","drosha, ribonuclease type III","Drosha","Nil","1110013A17Rik, Etohi2, Rnasen","MGI:1261425","drosha, ribonuclease type III; targeted mutation 1, Dan R Littman","Drosha<tm1Litt>","MGI:3801076","15",{"$nulls":28},"When bred to mice with a cre recombinase gene under the control of a promoter of interest, exon 9 is excised in the tissue of interest. Full knockouts of this gene are embryonic lethal before embryonic day 10.5 (E10.5).","These mice possess loxP sites on either side of exon 9 of the ribonuclease III, nuclear gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. ","C57BL/6J ","No","Yes","Yes","No","Yes","Yes","No","Unknown","Unknown",null,null,"Yes","2021-05-14","Live",0,30,"ANU",null,"false",null,"David ","Tcharke","JCSMR","David.Tscharke@anu.edu.au",{"$nulls":3},"Riccardo ","Natoli","riccardo.natoli@anu.edu.au",null,null,"No"]
[8747,"ASD960:Orange:XB131","C57BL/6NCrlAnu-Xbp1<em3Anu>/AnuApb",null,"Recessive","X-box binding protein 1","Xbp1","Unknown","D11Ertd39e, TREB5, TREB-5, XBP-1","MGI:98970",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-02","Cryopreserved sperm",66,0,"ANU",null,"true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[9190,"Ago2","B6.129P2(129S4)-Ago2<tm1.1Tara>/AnuApb",null,"Recessive","argonaute RISC catalytic subunit 2","Ago2","Nil","1110029L17Rik, 2310051F07Rik, argonaute 2, Eif2c2, mKIAA1567","MGI:2446632","argonaute RISC catalytic subunit 2; targeted mutation 1.1, Alexander Tarakhovsky","Ago2<tm1.1Tara>","MGI:4839762","15",{"$nulls":28},"These mice possess loxP sites on either side of exons 9-11 in the Eif2c2 (eukaryotic translation initiation factor 2C, 2) gene, also known as Ago2. Mice that are homozygous for this floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, the Mid domain is deleted and Ago2 expression is lost, causing functional inactivation of the gene.","Unknown","C57BL/6J ","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown","Unknown",null,null,"Yes","2021-05-21","Live",0,30,"ANU",null,"false",null,"David","Tcharke","JCSMR","David.Tscharke@anu.edu.au",{"$nulls":3},"Riccardo","Natoli","riccardo.natoli@anu.edu.au",null,null,"No"]
[6641,"NOD.HinsATriple427","NOD.Cg-H2<dlAb1-Ea> Tg(Cd4-CD4)2362Litt Tg(HLA DR4-DQ8)427 Tg(Ins2-INS1)/Apb",null,"Dominant","histocompatibility-2, MHC","H2","Nil","H-2, MHC-II","MGI:95894","histocompatibility-2, MHC; targeted deletion, H2 complex","H2<dlAb1-Ea>","MGI:2658725","17",{"$nulls":15},"No","human leukocyte antigen class II",{"$nulls":13},"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2011-11-03","Cryopreserved sperm",45,83,"St V",null,"false",null,"Stuart","Mannering","St Vincent's Institute","smannering@svi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[{"$nulls":30},"transgene insertion 2362, Dan R Littman","murine Cd4 and human CD4","equivalent to human CD4+ cells"]
[{"$nulls":30},"human insulin","rat insulin promoter (RIP) (Ins2)"]
[8739,"LAMA5 HS PM","C57BL/6-Lama5<em1Marp>/MarpApb",null,"Recessive","Laminin, alpha 5","Lama5","Unknown","mKIAA0533","MGI:105382",{"$nulls":3},"2",{"$nulls":28},"Lethal","unknown","C57BL/6","No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2019-06-26","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[9076,"R26-YAP5SA","C57BL/6-Gt(ROSA)26Sor<(CAGGS-Yap5SA,LacZ)Mao>/Apb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",{"$nulls":3},"6",{"$nulls":28},"Overexpression of activated YAP (NLS-YAP-5SA) with Keratin-5 (K5-CreERt) is sufficient to induce rapid formation of both SCC and spSCC in mice. spSCC tumours arise at sites of epithelial scratch wounding, where tumour-initiating epithelial cells undergo EMT to generate spSCC. Expression of the EMT transcription factor ZEB1 arises upon wounding and is a defining characteristic of spSCC in mice and humans. Thus, the wound healing response synergises with YAP to drive metaplastic transformation of SCC to spSCC.",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-09-09","Cryopreserved sperm",50,0,"ANU","994","false",null,"Barry","Thompson","The Australian National University","barry.thompson@anu.edu.au",{"$nulls":8},"No"]
[8740,"ASD977:Zambrero:6","C57BL/6NCrlAnu-Ryr2<em2Anu>/AnuApb",null,"Recessive","ryanodine receptor 2, cardiac","Ryr2","Unknown","9330127I20Rik","MGI:99685",{"$nulls":3},"13",{"$nulls":28},"Unknown","Normal","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-06-28","Cryopreserved sperm",33,0,"ANU","977","true",null,"Nikki","Ross","Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[7957,"Castella","C.Cg-Rag2<tm1Fwa> Tg(CD2-IL5)5C2Ldt/AnuApb",null,"Recessive","recombination activating gene 2","Rag2",null,"Rag-2","MGI:97849","recombination activating gene 2; targeted mutation 1, Frederick W Alt","Rag2<tm1Fwa>","MGI:1858556","2",{"$nulls":16},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":9},"Constitutive expression of the IL5 gene is sufficient to induce lifelong high-level eosinophilia.    ","Appear normal with peripheral blood eosinophilia and increased numbers of eosinophils in the spleen (with splenomegaly), bone marrow.  Heterozygous BALB/c and C57BL/6 IL-5 Tg2 mice are resistant to methylcholanthrene-induced carcinogenesis - see Simson, L, et al., 2007, Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol., 178:4222-4229.","BALB/c","No","No","Yes","No","No","Yes","No","Excellent","20",null,"Transgenic male with wild type female","No","2015-07-28","Cryopreserved sperm",22,0,"ANU","176","false",null,"The Australian","Phenomics Facility","The Australian National University","contact@australianphenomics.org.au",{"$nulls":3},"Katrina","Bowditch","katrina.bowditch@anu.edu.au","N/A","N/A","No"]
[9032,"Youngs","C.Cg-Tg(CD2-IL5)5C2Ldt/AnuApb",null,"Recessive",{"$nulls":25},"transgene insertion 5C2, Lindsay A Dent","the dominant control region (DCR) of the gene encoding human CD2","High - 49 Copies",{"$nulls":11},"BALB/c","No","No","Yes","No","No","Yes","No","Excellent","20",null,"Transgenic male with wild type female","No","2020-06-26","Cryopreserved sperm",55,0,"ANU","176","false",null,"Chris","Parish","Australian National University","christopher.parish@anu.edu.au",{"$nulls":8},"No"]
[8125,"Er81 fl:PV-Cre","B6.129-Etv1<tm1Wds> Pvalb<tm1(cre)Arbr>/Anu",null,"Recessive","ets variant 1","Etv1","Unknown","ER81, Etsrp81","MGI:99254","ets variant 1; targeted mutation 1, William D Snider","Etv1<tm1Wds>","MGI:2663693","12",{"$nulls":28},"Unknown",null,"C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2016-10-28","Cryopreserved sperm",24,0,"ANU","791","true",null,"Nathalie","Dehorter","The Australian National University","nathalie.dehorter@anu.edu.au",{"$nulls":8},"No"]
[8125,"Er81 fl:PV-Cre","B6.129-Etv1<tm1Wds> Pvalb<tm1(cre)Arbr>/Anu",null,"Recessive","parvalbumin","Pvalb",null,"Parv, PV, Pva","MGI:97821","parvalbumin; targeted mutation 1, Silvia Arber","Pvalb<tm1(cre)Arbr>","MGI:3590684","15"]
[9194,"Dmd S3059A","BALB/c-Dmd<em1>/Anu Apb",null,"Semi-dominant","Dystrophin ","Dmd",null,"Dp427, Dp71, Duchenne muscular dystrophy, dys, mdx, pke, X-linked muscular dystrophy","MGI:94909","Dmd","Dmd<S3059A>",null,"X",{"$nulls":28},"Unknown","Unknown","Balb/cJ","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-02","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Kristy","Swiderski",null,"kristys@unimelb.edu.au",{"$nulls":8},"No"]
[9193,"DmdS3059E","Balb/c-Dmd<tm1>/AnuApb",null,"Semi-dominant","Dystrophin","Dmd",null,"Dp427, Dp71, Duchenne muscular dystrophy, dys, mdx, pke, X-linked muscular dystrophy ","MGI:94909","Dmd","Dmd<em1(S3059E)>",null,"X",{"$nulls":28},"Unknown","Unknown","Balb/cJ","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-02","Cryopreserved sperm",50,0,null,null,"true",null,"Kristy","Swiderski",null,"kristys@unimelb.edu.au",{"$nulls":8},"No"]
[8284,"Spi6 KO ; Spi6<GFP>","C57BL/6-Serpinb9<tm1.1Pib>/Marp",null,"Recessive","serine (or cysteine) peptidase inhibitor, clade B, member 9","Serpinb9","Unknown","ovalbumin, PI-9, Spi6","MGI:106603","serine (or cysteine) peptidase inhibitor, clade B, member 9; targeted mutation 1.1, Phillip I Bird","Serpinb9<tm1.1Pib>","MGI:5140012","13",{"$nulls":28},"immune system phenotype ( J:252016 )N \t• mice exhibit normal thymus and spleen cellularity and numbers of dendritic cells, splenic CD4 T cells, CD8 T cells, NK cells and CD103+CD8+ dendritic cellsabnormal immune system morphology ( J:252016 )\t• authors state that the base phenotype resembles that of Serpinb9tm1Arpabnormal immune system physiology ( J:252016 )\t• authors state that the base phenotype resembles that of Serpinb9tm1Arpdecreased cytotoxic T cell apoptosis ( J:252016 )\t• in mice immunized with apoptotic cells displaying ovalbumin due to a dendritic cell dependent priming deficitabnormal dendritic cell antigen presentation ( J:252016 )\t• impaired cross-presentation• however, dendritic cells exhibit normal antigen uptake, survival after antigenic challenge and antigen degradation machinery",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2017-08-16","Cryopreserved sperm",12,0,"ANU","860","true",null,"David","Tscharke","The Australian National University","david.tscharke@anu.edu.au",{"$nulls":8},"No"]
[8614,"Ubtf<E210K>","C57BL/6J-Ubtf<tm1.1Ldx>/AnuApb",null,"Recessive","upstream binding transcription factor, RNA polymerase I","Ubtf",null,"A930005G04Rik, Tcfubf, UBF, UBF1","MGI:98512","pstream binding transcription factor, RNA polymerase I; targeted mutation 1, Mark LeDoux","Ubtf<tm1.1Ldx>","MGI:6695077","11",{"$nulls":28},"Unknown",null,"C57BL/6J","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2018-11-27","Cryopreserved sperm",10,0,"ANU",null,"false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":3},"Rita","Ferreira","Rita.Ferreira@anu.edu.au",null,null,"No"]
[8938,"ENU33:Trex1:cGAS KO","B6.Cg-Cgas<tm1d(EUCOMM)Hmgu> Trex1<m1Anu>/AnuApb",null,"Recessive","cyclic GMP-AMP synthase","Cgas","Nil","E330016A19Rik, Mb21d1","MGI:2442261","cyclic GMP-AMP synthase; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH","Cgas<tm1d(EUCOMM)Hmgu>","MGI:5578170","9",{"$nulls":28},"unknown","unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-03-28","Cryopreserved sperm",20,0,"ANU",null,"true",null,"Carola ","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8938,"ENU33:Trex1:cGAS KO","B6.Cg-Cgas<tm1d(EUCOMM)Hmgu> Trex1<m1Anu>/AnuApb",null,"Recessive","three prime repair exonuclease 1","Trex1",null,null,"MGI:1328317",{"$nulls":3},"9"]
[9197,"ASD1109:Ezr:20:F0","C57BL/6NCrlAnu-Ifr4<em2>/AnuApb",null,"Semi-dominant","ezrin","Ezr",null,"cytovillin, ezrin, p81, Vil2","MGI:98931","Ezr<em2>","Ezr:20:F0",null,"17",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-03","Cryopreserved sperm",12,0,null,null,"true",null,"Carola","Vinueasa","ANU","carola.vinueasa@anu.edu.au",{"$nulls":8},"No"]
[8546,"Foz:Jnk1 KO","B6(Cg)-Alms1<foz> Mapk8<tm1Flv>/AnuApb",null,"Recessive","Alstrom syndrome 1 homolog (human)","Alms1","Unknown",null,"MGI:1934606","Alstrom syndrome 1 homolog (human); fat aussie","Alms1<foz>","MGI:3621984","6",{"$nulls":15},"Yes",{"$nulls":12},"Mice are hyperphagic leading to obesity. Males are sterile. High fat feeding accelerates obesity development, and leads to nonalcoholic steatohepatitis which progresses to liver fibrosis. Steatohepatitis also develops in chow-fed animals.Hyperglycemia: female mice are diabetic by 200 days of age.Increased circulating insulin level: female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type).Insulin resistance: female mice develop insulin resistance by 200 days of age.Increased eating behavior: mutants eat more than wild-type.Abnormal hepatocyte morphology: mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells.Enlarged liver: mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g).Increased liver weight: liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g).Liver fibrosis: mutant livers show pericellular and pericentral fibrosis.Hepatic steatosis: chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis.Jnk1 KO mice are susceptible to infection when challenged with the intracellular pathogen, Leishmania major. Primary murine embryonic fibroblasts prepared from mutant embryos are partially protected from UV-induced apoptosis.","Normal","C57BL/6","Yes","Unknown","Yes","Yes","No","Yes","Yes","Good",">10",null,"heterozygote mating","No","2018-08-06","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Geoff","Farrell","The Canberra Hospital","geoff.farrell@anu.edu.au",{"$nulls":3},"Vanessa","Barn","vanessa.barn@anu.edu.au",null,null,"Yes"]
[8546,"Foz:Jnk1 KO","B6(Cg)-Alms1<foz> Mapk8<tm1Flv>/AnuApb",null,"Recessive","mitogen-activated protein kinase 8","Mapk8","Nil","c-Jun N-terminal kinase, JNK1, Prkm8 ","MGI:1346861","mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell","Mapk8<tm1Flv>","MGI:2176239","14",{"$nulls":58},"Vanessa","Barn","vanessa.barn@anu.edu.au"]
[8752,"LAMA5 HS","C57BL/6-Lama5<em2Marp>/MarpApb",null,"Recessive","Laminin, alpha 5","Lama5","Unknown","mKIAA0533","MGI:105382",{"$nulls":3},"2",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-18","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[8753,"CLDN10 PM","C57BL/6-Cldn10<em1Marp>/MarpApb",null,"Recessive","claudin 10","Cldn10","Unknown","6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e","MGI:1913101",{"$nulls":3},"14",{"$nulls":28},"Affects ion transport in the kidney","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-18",null,0,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[8738,"CRISP4 KO","C57BL/6N-Crisp4<tm1(KOMP)>/MarpApb",null,"Recessive","cysteine-rich secretory protein 4","Crisp4","Nil","9230112K08Rik","MGI:1925331","cysteine-rich secretory protein 4; targeted mutation 1a, Wellcome Trust Sanger Institute","Crisp4<tm1a(KOMP)Wtsi>","MGI:4363007","1",{"$nulls":28},"Sub-fertile","Nomrmal","C57BL/6N","Yes","Yes","Yes","Yes","No","Yes","No","Unknown",{"$nulls":3},"No","2019-06-24","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Moira","O'Bryan","Monash University","moira.obryan@monash.edu",{"$nulls":8},"No"]
[8757,"R26-LSL-Adar1 E861A","C57BL/6-Gt(ROSA)26Sor<tm4(Adar1E861A)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",null,"Gt(ROSA)26Sor<tm4(Adar1E861A)Cwa>",null,"6",{"$nulls":28},"Normal (requires Cre to induce expression of editing deficient Adar1 - both p110 and p150 isoforms)","Normal (requires Cre to induce expression of editing deficient Adar1 - both p110 and p150 isoforms)","C57BL/6","Yes","Yes","Unknown","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-31","Cryopreserved sperm",70,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[8758,"ASD783:Man2a1:GtoC","C57BL/6NCrlAnu-Man2a1<m2Anu>/AnuApb",null,"Recessive","mannosidase 2, alpha 1","Man2a1",null,"Mana2, Mana-2, Map-2","MGI:104669",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-31","Cryopreserved sperm",22,0,"ANU","783","true",null,"Julia","Ellyard","Australian National University","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[9204,"Tek-cre","B6.Cg-Tg<(Tek-cre)1Ywa>/J",null,"Dominant",{"$nulls":8},"Unknown",{"$nulls":16},"transgene insertion 1, Masashi Yanagisawa","mouse Tek promoter and enhancer","Unknown","sortilin-related VPS10 domain containing receptor 2","Sorcs2 ",null,"mKIAA1329, VPS10 domain receptor protein","MGI:1932289",{"$nulls":3},"5","Normal","Normal","C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-17","Cryopreserved sperm",50,0,null,null,"false",null,"Jessica","Briffa","University of Melbourne","jessica.briffa@unimelb.edu.au",{"$nulls":8},"No"]
[8756,"R26-LSL-Adar1 p110","C57BL/6-Gt(ROSA)26Sor<tm2(Adar1p1100)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735",null,"Gt(ROSA)26Sor<tm2(Adar1p110)Cwa>",null,"6",{"$nulls":28},"Normal (requires Cre to induce expression of Adar1 p110 isoform ectopically)","Normal (requires Cre to induce expression of Adar1 p110 isoform ectopically)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-07-31","Cryopreserved sperm",40,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[8760,"ASD873:XBP1:indel","C57BL/6NCrlAnu-Xbp1<em4Anu>/AnuApb",null,"Recessive","X-box binding protein 1","Xbp1","Unknown","D11Ertd39e, TREB5, TREB-5, XBP-1","MGI:98970",{"$nulls":3},"11",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-08-02","Cryopreserved sperm",11,0,"ANU","873","true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[8762,"ENU25:041:Casd1:comp","C57BL/6NCrlAnu-Casd1<m2Anu>/AnuApb",null,"Recessive","CAS1 domain containing 1","Casd1","Unknown","Cast1, MGC:6840","MGI:2384865",{"$nulls":3},"6","ENSMUSG00000015189","ENSMUST00000015333","Casd1-001",{"$nulls":8},"1",{"$nulls":16},"TER119 negative RBCs","Normal","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-08","Cryopreserved sperm",57,0,"ANU",null,"true",null,"Robert","Tunningley","Australian National University","robert.tunningley@anu.edu.au",{"$nulls":8},"No"]
[8786,"R26-LSL-Adar1 p150","C57BL/6-Gt(ROSA)26Sor<tm3(Adar1p150)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,null,"MGI:104735",null,"Gt(ROSA)26Sor<tm3(Adar1p150)Cwa>",null,"6",{"$nulls":28},"Normal (requires Cre treatment to activate expression of Adar1 p150 isoform)","Normal (requires Cre treatment to activate expression of Adar1 p150 isoform)","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-06","Cryopreserved sperm",40,0,"St V",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[8776,"ENU35:042:B6","B6(Cg)-Ifih1<m1Anu>/Anuapb",null,"Recessive","interferon induced with helicase C domain 1","Ifih1",null,"9130009C22Rik, Helicard, MDA5, MDA-5","MGI:1918836",{"$nulls":3},"Unknown",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-12","Cryopreserved sperm",67,0,"ANU",null,"true",null,"Julia","Ellyard","ANU","julia.ellyard@anu.edu.au",{"$nulls":8},"No"]
[9221,null,"Drosha CD4-cre Foxp3-GFP",null,"Dominant","Drosha & Foxp3",{"$nulls":4},"Flox (Drosha) & IRES-GFP knockin (Foxp3)",null,null,"Unknown",{"$nulls":16},"CD4-cre","CD4 promoter/enhancer/silencer",{"$nulls":10},"Reduction of certain T cell populations. All Treg cells are labelled with GFP. Older animals (at least 6 months) can develop spontaneous inflammatory disease, which reduces lifespan","Normal. However, in females there are heterozygous for the Foxp3-GFP knockin, only half of the Treg cells in the animal will be labelled with GFP.","C57BL/6 (backcrossed >10 generations)","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-08","Cryopreserved sperm",49,0,null,null,"false",null,"Mark","Chong","St Vincent's Institute of Medical Research","mchong@svi.edu.au",{"$nulls":8},"No"]
[9123,"Becn1 floxed","C57BL/6NTac-Becn1<tm1c(KOMP)Wtsi>",null,"Semi-dominant","beclin 1, autophagy related","Becn1 ",null,"Atg6","MGI:1891828","beclin 1, autophagy related; targeted mutation 1c, Wellcome Trust Sanger Institute","Becn1<tm1c(KOMP)Wtsi>","MGI:6449262","Unknown",{"$nulls":28},"Normal","Normal","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-20","Cryopreserved sperm",40,0,"ANU",null,"true",null,"Erinna","Lee",null,"erinna.lee@onjcri.org.au",{"$nulls":8},"No"]
[8782,"R26-Adar1","C57BL/6-Gt(ROSA)26Sor<tm1(Adar1)Cwa>/CwaApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,null,"MGI:104735","Gt(ROSA)26Sor<tm1(Adar1)Cwa>",null,null,"6",{"$nulls":28},"Normal (Rosa26 Lox-Stop-Lox Adar1 cDNA); needs Cre exposure to activate Adar1 expression","Normal (Rosa26 Lox-Stop-Lox Adar1 cDNA); needs Cre exposure to activate Adar1 expression","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-09-04","Cryopreserved sperm",60,0,null,null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[9247,"Ntsr1-cre","FVB/N-Tg(Ntsr1-cre)<GN209Gsat>",null,"Semi-dominant","neurotensin receptor 1","Ntsr1",null,"NT-1R, NTR1, NTR-1, Ntsr1","Ntsr1","ransgene insertion GN209, GENSAT Project at Rockefeller University","Tg(Ntsr1-cre)GN209Gsat","MGI:4367043","Unknown",{"$nulls":16},"cre recombinase","Ntsr1",{"$nulls":10},"Undetermined","Undetermined","FVB/N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"N1F2"," hemizygous state","No","2021-08-09",null,0,0,null,null,"false",null,"Greg","Stuart","ANU","greg.stuart@anu.edu.au",{"$nulls":8},"No"]
[8415,"Mdm2<WT>  S6<WT>","B6(Cg).129(Cg)-WT/JAnu",null,"Recessive",{"$nulls":37},"Normal",null,"C57BL/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-01-15","Cryopreserved sperm",55,0,"ANU",null,"false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":8},"No"]
[9223,"Alb-Kb B10.BR"," Tg(Alb-H2-Kb)/Apb or Alb-Kb",null,"Semi-dominant","H-2Kb (histocompatibility 2, K region; b haplotype)","h2-k1","Normal",{"$nulls":5},"Unknown",{"$nulls":16},"H-2Kb (histocompatibility 2, K region; b haplotype)","mouse albumin promoter",{"$nulls":10},"This transgenic mouse line expresses a mouse MHC Class I molecule H-2Kb under the control of the mouse albumin promoter, allowing restricted expression of H-2Kb in hepatocytes in addition to endogenous H-2K molecules expression in all cells (Including hepatocytes). The original mouse line was originally generated in the DBA2 background (H-2 d haplotype). To generate Alb-Kb on the B10.BR background (k background), the original line was backcrossed  for >10 generations with B10BR mice. Mice have a normal phenotype and no liver anomaly.","Same as above.","B10.BR","Yes","Yes","Yes","Yes","Yes","Yes","No","Excellent","more than 10",null,"Homozygous mice are intercrossed","No","2021-07-08","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Bertolino","Centenary Institute","p.bertolino@centenary.org.au",{"$nulls":8},"No"]
[8779,"Maggott:13","NOD/Lt-Slc6a19<em1Anu>/13AnuApb",null,"Recessive","solute carrier family 6 (neurotransmitter transporter), member 19","Slc6a19",null,"4632401C08Rik, B<0>AT1","MGI:1921588",{"$nulls":3},"13",{"$nulls":30},"NOD/Lt","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-15","Cryopreserved sperm",55,0,"ANU",null,"true",null,"Chris","Nolan","The Canberra Hospital","christopher.nolan@anu.edu.au",{"$nulls":8},"No"]
[7870,"MHC II KO","B6NCrl.Cg-H2-Aa<tm1Blt>/AnuApb",null,"Recessive","histocompatibility 2, class II antigen A, alpha","H2-Aa",null,"Aalpha, A alpha, H-2Aa, Ia1, Ia-1, I-Aalpha","MGI:95895","histocompatibility 2, class II antigen A, alpha; targeted mutation 1, Horst Bluethmann","H2-Aa<tm1Blt>","MGI:2157977","17",{"$nulls":28},"enlarged thymus ( J:16372 )• slightly enlargedthymus hyperplasia ( J:16372 )• slightly increased cell numberabnormal T cell morphology ( J:16372 )decreased CD4-positive, alpha beta T cell number ( J:16372 )• very few or no CD4+ T-cells in thymus• about 4% CD4+ peripheral T-cells as opposed to 60% normallyincreased CD8-positive, alpha-beta T cell number ( J:16372 )• about 90% of lymph node T-cells are CD8+abnormal MHC II cell surface expression on macrophages ( J:67924 )• Class II expression is absent on bone-marrow derived macrophagesabnormal splenocyte physiology ( J:16372 )• no splenocyte response to staphylococcal enterotoxin B• response to T-cell independent antigens is normalenlarged lymph nodes ( J:16372 )• slightly enlarged",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-04-16","Cryopreserved sperm",43,0,"ANU",null,"false",null,"Anselm","Enders","The Australian National University","anselm.enders@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[8781,"ENU23:039:Pola1","C57BL/6NCrlAnu-Pola1<m1Anu> Pola1<m2Anu>/AnuApb",null,"Recessive","polymerase (DNA directed), alpha 1","Pola1",null,"Pola","MGI:99660",{"$nulls":3},"X",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-08-30","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Qian ","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[9245,"Ggnbp2 fl/fl","C57Bl6/J-Ggnbp2<(tm1.1)Crwy>/AnuApb",null,"Recessive","gametogenetin binding protein 2","Ggnbp2",null,"D330017P12Rik, DIF-3, Zfp403 ","MGI:2387356","Ggnbp2<(tm1.1)Crwy>",null,null,"Unknown",{"$nulls":28},"conditional allele; no phenotype in homozygous state; currently unknown after somatic deletion","normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-08-04","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[5015,"MHC II KO","B6.129-H2-Aa<tm1Blt>/AnuApb",null,"Recessive","histocompatibility 2, class II antigen A, alpha","H2-Aa","Nil","Aalpha, A alpha, H-2Aa, Ia1, Ia-1, I-Aalpha","MGI:95895","histocompatibility 2, class II antigen A, alpha; targeted mutation 1, Horst Bluethmann","H2-Aa<tm1Blt>","MGI:2157977","17",{"$nulls":28},"enlarged thymus ( J:16372 )• slightly enlargedthymus hyperplasia ( J:16372 )• slightly increased cell numberabnormal T cell morphology ( J:16372 )decreased CD4-positive, alpha beta T cell number ( J:16372 )• very few or no CD4+ T-cells in thymus• about 4% CD4+ peripheral T-cells as opposed to 60% normallyincreased CD8-positive, alpha-beta T cell number ( J:16372 )• about 90% of lymph node T-cells are CD8+abnormal MHC II cell surface expression on macrophages ( J:67924 )• Class II expression is absent on bone-marrow derived macrophagesabnormal splenocyte physiology ( J:16372 )• no splenocyte response to staphylococcal enterotoxin B• response to T-cell independent antigens is normalenlarged lymph nodes ( J:16372 )• slightly enlarged",null,"C57BL/6JAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2010-02-22","Cryopreserved sperm",80,0,"ANU","088","false",null,"The Australian","Phenomics Facility","The Australian National University","alistair.reid@anu.edu.au",{"$nulls":6},"N/A","N/A","No"]
[9228,"Ocn-Cre","B6.FVB-Tg<BGLAP-cre>1/Clem/J",null,"Semi-dominant",{"$nulls":25},"transgene insertion 1, Thomas Clemens","human bone gamma carboxyglutamate protein (BGLAP)","Unknown",{"$nulls":9},"Transgenic ","unknown","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-19","Cryopreserved sperm",50,0,null,null,"false",null,"Roshlien","Prakash","Kearns Facility","roshlien.prakash@health.nsw.gov.au",{"$nulls":8},"No"]
[9233,"ENU51:019","C57BL/6Ncrl:ENU51<019>/Anu",null,"Dominant","Not known yet",{"$nulls":7},"Unknown",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-26","Cryopreserved sperm",12,0,null,null,"true",null,"Anna","Palkova","APF","anna.palkova@anu.edu.au",{"$nulls":8},"No"]
[9258,"Ezr:Q339R","C57BL/6NCrlAnu-Ezr<em1(Q339R)Anu>/AnuApb ",null,"Semi-dominant","Ezrin","Ezr",null,"cytovillin, ezrin, p81, Vil2 ","MGI:98931","Ezrin","Ezr<Q339R> ",null,"17",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-08-12","Cryopreserved sperm",53,0,"ANU",null,"true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Koula","Diamand","koula.diamand@anu.edu.au",null,null,"No"]
[9257,"Irf2bp2:R38C ","C57BL/6NCrlAnu-Irf2bp2<em1(R38C)Anu>/AnuApb ",null,"Semi-dominant","interferon regulatory factor 2 binding protein 2","Irf2bp2",null,"E130305N23Rik ","MGI:2443921","Interferon regulatory factor 2 binding protein 2","Irf2bp2 <R38C>",null,"8",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-08-12","Cryopreserved sperm",55,0,"ANU",null,"true",null,"Matthew","Cook","Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Koula","Diamand","koula.diamand@anu.edu.au",null,null,"No"]
[9250,"Akirin F0:#23","C57BL/6NCrlAnu-Akirin<em5>/AnuApb",null,"Semi-dominant","akirin 1","Akirin1",null,"6330407G11Rik","MGI:1915300","endonuclease mediated targeting 5;","Akirin F0:#23",null,"Unknown",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-08-11","Cryopreserved sperm",11,0,null,null,"true",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":8},"No"]
[8791,"ASD739:ELK KO","C57BL/6NCrlAnu-Elk1<em1Anu>/AnuApb",null,"Recessive","ELK1, member of ETS oncogene family","Elk1",null,"Elk-1","MGI:101833",{"$nulls":3},"X",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-09-17","Cryopreserved sperm",58,0,"ANU","739","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8792,"ASD739:ELK KO:37bp-Del","C57BL/6NCrlAnu-Elk1<em2Anu>/AnuApb",null,"Recessive","ELK1, member of ETS oncogene family","Elk1",null,"Elk-1","MGI:101833",{"$nulls":3},"X",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-09-17","Cryopreserved sperm",56,0,"ANU","739","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8793,"Ubl3","C57BL/6-Ubl3<em1>/Apb",null,"Recessive","ubiquitin-like 3","Ubl3",null,null,"MGI:1344373",{"$nulls":3},"5",{"$nulls":28},"Unknown",null,"C57BL/6","Yes","Unknown","Yes","Yes","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-09-17","Cryopreserved sperm",50,0,null,null,"true",null,"Justine","Mintern","Bio21","jmintern@unimelb.edu.au",{"$nulls":8},"No"]
[8748,"S1ECN*Smad1-ERT-cre-neu","STOCK Smad1<tm2Rob> Tg(Elf5-rtTa-TetO) Tg(MMTVneu)202Mul/Apb",null,"Recessive","SMAD family member 1","Smad1",null,"Madh1, Madr1, Smad 1","MGI:109452","SMAD family member 1; targeted mutation 2, Elizabeth J Robertson","Smad1<tm2Rob>","MGI:2155484","8",{"$nulls":16},"Elf5-rtTa-TetO",{"$nulls":11},"These mice are normal and breed well, and develop normally. Adult mice older than 6 month may develop multiple tumours in mammary glands.Younger mice seem to be more active than wild type mice. At the moment the phenotype of smad1 CRE/ERT mediated deletion is unknown.Doxycycline is required from a young age for effective knockout of Smad1.","ERT/CRE  and NEU modifications are active in heterozygous setting, so the above phenotype is the same. Smad1 flox is required in the homozygous state for effective knockout.","mixed-mainly BALBc and FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-04","Cryopreserved sperm",50,0,null,null,"true",null,"Robin","Anderson","Olivia Newton John Cancer Research Institute","robin.anderson@onjcri.org.au",{"$nulls":8},"No"]
[{"$nulls":30},"transgene insertion 202, William Muller","MMTV"]
[8755,null,"FVB(Cg)-Ccnd1<tm5.1Pisc> Tg(CAG-cre/Esr1*)5Amc Tg(MMTV-rtTA) Tg(tetO-HER2)",null,"Recessive","cyclin D1","Ccnd1","Unknown","bcl-1, cD1, CycD1, Cyl-1, PRAD1 ","MGI:88313 ","cyclin D1; targeted mutation 5.1, Piotr Sicinski","Ccnd1<tm5.1Pisc>","MGI:5468336","7",{"$nulls":16},"transgene insertion 5, Andrew P McMahon",{"$nulls":13},">87.5% FVB","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-07-30","Cryopreserved sperm",44,0,"ANU",null,"true",null,"Shom","Goel","Peter MacCullum Cancer Centre","shom.goel@petermac.org",{"$nulls":8},"No"]
[{"$nulls":30},"transgene insertion 1, Lewis A Chodosh"]
[{"$nulls":30},"transgene insertion, Jean J Zhao"]
[8763,"F9 human KI, mouse KO (165D) ","B6-F9<tm1(F9)Csl>/165DCslApb",null,"Recessive","coagulation factor IX","F9",null,"Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8764,"F8 KO (72A)","C57BL/6-F8<tm1Csl>/72ACslApb",null,"Recessive","coagulation factor VIII","F8","Nil","Cf8, Cf-8, Factor VIII, FVIII","MGI:88383",{"$nulls":3},"X",{"$nulls":28},"Mice are haemophilic as they are deficient in the clotting factor, FVIII","Mice may show signs of being haemophilic","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",40,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8770,"F9 human KI, mouse KO (165B) ","C57BL/6-F9<tm1(F9)Csl>/165BCslApb",null,"Recessive","coagulation factor IX","F9",null,"Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8769,"F9 human KI, mouse KO (165A) ","C57BL/6-F9<tm1(F9)Csl>/165ACslApb",null,"Recessive","coagulation factor IX","F9",null,"Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8775,"F9 human KI, mouse KO (202B)","C57BL/6-F9<tm1(F9)Csl>/202BCslApb",null,"Recessive","coagulation factor IX","F9","Nil","Cf9, Cf-9","MGI:88384",{"$nulls":3},"X",{"$nulls":28},"Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","Mice may exhibit haemophilia B - it is unknown to what degree the human F9 clotting factor compensates.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8766,"F8 KO (80A)","C57BL/6-F8<tm1Csl>/80ACslApb",null,"Recessive","coagulation factor VIII","F8","Nil","Cf8, Cf-8, Factor VIII, FVIII","MGI:88383",{"$nulls":3},"X",{"$nulls":28},"Mice are haemophilic as they are deficient in the clotting factor, FVIII.","Mice may be haemophilic.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",30,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[8767,"F8 KO (80B)","C57BL/6-F8<tm1Csl>/80BCslApb",null,"Recessive","coagulation factor VIII","F8",null,"Cf8, Cf-8, Factor VIII, FVIII","MGI:88383",{"$nulls":3},"X",{"$nulls":28},"Mice are haemophilic as they are deficient in the clotting factor, FVIII.","Mice may be haemophilic.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-08-09","Cryopreserved sperm",50,0,null,null,"true",null,"Amanda","Turner","CSL Ltd","Amanda.Turner@csl.com.au",{"$nulls":8},"No"]
[9241,"PANX1nc","C57BL/6N-PANX1nc<em D375A/D378A>/APB",null,"Semi-dominant","Pannexin 1","Panx1 ",null,null,"MGI:1860055 ","Pannexin","PANX1nc<em D375A/D378A>",null,"9",{"$nulls":28},"Normal","Normal","C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-29","Cryopreserved sperm",70,0,null,null,"true",null,"Ivan","Poon",null,"I.Poon@latrobe.edu.au",{"$nulls":8},"No"]
[8802,"ASD1034:Blackcurrant:1:N1","C57BL/6NCrlAnu-Slc7a9<em1Anu>/AnuApb",null,"Recessive","solute carrier family 7 (cationic amino acid transporter, y+ system), member 9","Slc7a9","Unknown","b<o>, + amino acid transporter, b<o>, +AT, CSNU3","MGI:1353656",{"$nulls":3},"7",{"$nulls":28},"Mice may develop lupus-like symptoms","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-10","Cryopreserved sperm",12,0,"ANU","1034","true",null,"Nikki","Ross","Australian National University","nikki.ross@anu.edu.au",{"$nulls":8},"No"]
[8803,"ASD899:Lychee:Ct4bpdel","C57BL/6NCrlAnu-Ctbp1<em1Anu>/AnuApb",null,"Recessive","C-terminal binding protein 1","Ctbp1","Unknown","BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115","MGI:1201685",{"$nulls":3},"5",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-11","Cryopreserved sperm",29,0,"ANU","899","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8805,"ASD900:Dragonfruit:PH196","C57BL/6NCrlAnu-Phrf1<em1Anu>/AnuApb",null,"Recessive","PHD and ring finger domains 1","Phrf1",null,null,"MGI:2141847",{"$nulls":3},"7",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-21","Cryopreserved sperm",44,0,"ANU","900","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8808,"ASD924:Longan:PA56","C57BL/6NCrlAnu-Pacsin1<em1Anu>/AnuApb",null,"Recessive","protein kinase C and casein kinase substrate in neurons 1","Pacsin1","Unknown","A830061D09Rik, mKIAA1379, Syndapin I","MGI:1345181",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-21",null,0,0,"ANU","924","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8810,"ASD951:Mangosteen:RA203","C57BL/6NCrlAnu-Rasal1<em1Anu>/AnuApb",null,"Recessive","RAS protein activator like 1 (GAP1 like)","Rasal1","Unknown","MRASAL","MGI:1330842",{"$nulls":3},"5",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-21","Cryopreserved sperm",46,42,"ANU","951","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8817,"ASD950:Rambutan:::F1","C57BL/6NCrlAnu-Tet2<em1Anu>/Anuapb",null,"Recessive","tet methylcytosine dioxygenase 2","Tet2","Unknown","Ayu17-449, E130014J05Rik, mKIAA1546","MGI:2443298",{"$nulls":3},"3",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-22","Cryopreserved sperm",57,50,"ANU","950","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8820,"ASD924:Longan:PA1bpdel","C57BL/6NCrlAnu-Pacsin1<em2Anu>/AnuApb",null,"Recessive","protein kinase C and casein kinase substrate in neurons 1","Pacsin1","Unknown","A830061D09Rik, mKIAA1379, Syndapin I","MGI:1345181",{"$nulls":3},"17",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-10-24","Cryopreserved sperm",65,41,"ANU","924","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[9280,"Tg(mAce2-hACE2)","C57BL/6J <Tg(mAce2-hACE2)26MGMP>/AnuApb",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"pAMP-mAce2 promoter-hACE2 cDNA-pA ","mouse Ace2 promoter","Unknown",{"$nulls":9},"Unknown","Unknown","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-10-05","Cryopreserved sperm",60,0,"Monash",null,"false",null,"Jeanette","Rientjes","Monash Genome Modification Platform, Monash University","mgmp@monash.edu",{"$nulls":8},"No"]
[9277,"LSA","B6;Balb-Gt(ROSA)26Sor<tm1(LgBit-SNAP-Actb)Aprj>/AnuApb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1 ","MGI:104735 ","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor<tm1(LgBit-SNAP-Actb)Aprj>",null,"6",{"$nulls":28},"Unknown","Unknown","Balb/c, C57BL/6J","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Unknown",{"$nulls":3},"No","2021-09-30",null,0,0,"ANU",null,"false",null,"Angus","Johnston",null,"angus.johnston@monash.edu",{"$nulls":8},"No"]
[9279,"Pthrpflox, PTHrPL2","B6;129-Pthlh<tm1Ack>/AnuApb","MGI:2387462","Recessive","parathyroid hormone-like peptide","Pthlh","Normal","parathyroid hormone-like hormone, parathyroid hormone-related peptide, parathyroid hormone-related protein, PTH-like, PTH-related peptide, Pthrp ","MGI:97800 ","parathyroid hormone-like peptide; targeted mutation 1, Andrew C Karaplis","Pthlh<tm1Ack>","MGI:2387462","6",{"$nulls":28},"Normal","Normal","C57Bl/6;129","Yes","Yes","Unknown","Yes","Yes","Unknown","No","Good",{"$nulls":3},"No","2021-10-05","Cryopreserved sperm",50,0,null,null,"false",null,"Natalie","Sims","St Vincent's Institute of Medical Research","nsims@svi.edu.au",{"$nulls":3},"Natalie","Wee","nwee@svi.edu.au",null,null,"No"]
[9275,"Irf4 em11.2^47bp","C57BL/6NCrlAnu-Ifr4<em11.2>/AnuApb",null,"Semi-dominant","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip","MGI:1096873","endonuclease mediated targeting 11.2;","Irf4 em11.2^47bp",null,"13",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-09-28","Cryopreserved sperm",11,0,null,null,"false",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":8},"No"]
[8823,"ASD951:Mangosteen:RA1bpdel","C57BL/6NCrlAnu-Rasal1<em2Anu>/AnuApb",null,"Recessive","RAS protein activator like 1 (GAP1 like)","Rasal1","Unknown","MRASAL","MGI:1330842",{"$nulls":3},"5",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-11-07","Cryopreserved sperm",65,35,"ANU","951","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[8824,"hIl3_GMCSF 20B","BALB/c-Csf2/Il3<tm1.1(CSF2,IL3)Flv>",null,"Dominant","colony stimulating factor 2 (granulocyte-macrophage)","Csf2",null,"Csfgm, Gm-CSf, GMCSF, MGI-IGM","MGI:1339752","colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1.1, Richard A Flavell","Csf2/Il3<tm1.1(CSF2,IL3)Flv>","MGI:4887879","11",{"$nulls":28},"mouse IL3 and GM-CSF have been KO and human IL3 and GM-CSF have been KI","unknown","balbc","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-11-08","Cryopreserved sperm",50,0,null,null,"true",null,"Julie","Pasquet","CSL ltd","julie.pasquet@csl.com.au",{"$nulls":8},"No"]
[8824,"hIl3_GMCSF 20B","BALB/c-Csf2/Il3<tm1.1(CSF2,IL3)Flv>",null,"Dominant","interleukin 3","Il3",null,"BPA, Csfmu, HCGF, Il-3, MCGF, PSF","MGI:96552","interleukin 3; targeted mutation 1.1, Richard A Flavell","Csf2/Il3<tm1.1(CSF2,IL3)Flv>","MGI:4887881","11"]
[8828,"ASD950:Rambutan:TE1806","C57BL/6NCrlAnu-Tet2<em2Anu>/Anuapb",null,"Recessive","tet methylcytosine dioxygenase 2","Tet2","Unknown","Ayu17-449, E130014J05Rik, mKIAA1546","MGI:2443298",{"$nulls":3},"3",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-11-22","Cryopreserved sperm",73,25,"ANU","950","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[9282,"Tg(DCLK1-CreERT2)Ernst;Dclk1tm1(EUCOMM)","C57Bl/6N-Tg<(DCLK1-CreERT2)Ernst>;Dclk1<tm1(EUCOMM)>/AnuApb",null,"Recessive","doublecortin-like kinase 1","DCKL1",null,"1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369 ","MGI:1330861","doublecortin-like kinase 1; targeted mutation 1a, Wellcome Trust Sanger Institute","Dclk1<tm1a(EUCOMM)Wtsi>","MGI:5543459","3",{"$nulls":16},"cre recombinase fused to the human estrogen receptor ligand binding domain","DCLK1",{"$nulls":10},"Normal","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-10-05",null,0,0,null,null,"false",null,"Michael","Buchert","Olivia Newton-John Cancer Research Institute","michael.buchert@onjcri.org.au",{"$nulls":8},"No"]
[9288,"ASD929:Gala:623del:Ly5a:N4  ","C57BL/6NCrlAnu-Gm14718<em1Anu> Ptprc<a>/Anu",null,"Dominant","predicted gene 14718","Gm14718","Unknown","lncRNA gene","MGI:3705113 ","endonuclease mediated targeting 1","lncRNA <623del>",null,"X",{"$nulls":28},"A slight decrease in CD40L expression in CD4 T cells when activated in vitro",null,"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-10-21","Cryopreserved sperm",46,0,null,null,"false",null,"Pablo","Fernandez De Canete Nieto","ANU","pablo.fernandez@anu.edu.au",{"$nulls":8},"No"]
[9148,"Stra8-iCre","C57BL6/J-Tg(Stra8-iCre)1Reb/LguJ",null,"Semi-dominant",{"$nulls":8},"Unknown",{"$nulls":16},"Tg(Stra8-icre)1Reb","Stra8",{"$nulls":10},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-02-17","Cryopreserved sperm",50,0,null,null,"false",null,"Moira","Obryan","Monash University / Melbourne University","moira.obryan@unimelb.edu.au",{"$nulls":8},"No"]
[9259,"Alox5AP:G75R","C57BL/6NCrlAnu-Alox5AP<em1(G75R)Anu>/AnuApb",null,"Semi-dominant","Arachidonate 5-lipoxygenase activating protein","Alox5AP ",null,"arachidonate 5 lipoxygenase activating protein, Flap ","MGI:107505","Arachidonate 5-lipoxygenase activating protein","Alox5AP <G75R> ",null,"Unknown",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-08-12","Cryopreserved sperm",57,0,"ANU",null,"true",null,"Carola","Vinuesa ","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":3},"Koula","Diamand","koula.diamand@anu.edu.au",null,null,"No"]
[9242,"Wdr26: 1bp insertion","C57BL/6NCrlAnu-Wdr26<em1Anu>/AnuApb",null,"Semi-dominant","WD repeat domain 26","Wdr26 ",null,"1600024A01Rik, Gid7","MGI:1923825",{"$nulls":3},"1",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-29","Cryopreserved sperm",33,0,"ANU",null,"true",null,"Matthew","Cook","Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Koula","Diamand","koula.diamand@anu.edu.au",null,null,"No"]
[9243,"Kif13a: G318R substitution","C57BL/6NCrlAnu-Kif13a<em1(G318R)Anu>/AnuApb ",null,"Semi-dominant","kinesin family member 13A","Kif13a",null,"1600024A01Rik, Gid7","MGI:1098264","kinesin family member 13A","Kif13a <G318R> ",null,"13",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-29","Cryopreserved sperm",58,0,"ANU",null,"true",null,"Matthew","Cook","Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Koula","Diamand","koula.diamand@anu.edu.au",null,null,"No"]
[9274,"Hoxb7-EGFP","C57BL/6J-Tg<(Hoxb7-EGFP)33Cos>/AnuApb",null,"Semi-dominant",{"$nulls":25},"EGFP","homeobox B7 promoter/enhancer sequences",{"$nulls":10},"not viable","normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-09-23","Cryopreserved sperm",50,0,"ANU",null,"false",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[8830,"ASD899:Lychee:Ct96","C57BL/6NCrlAnu-Ctbp1<em2Anu>/AnuApb",null,"Recessive","C-terminal binding protein 1","Ctbp1","Unknown","BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115","MGI:1201685",{"$nulls":3},"5",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-11-28","Cryopreserved sperm",19,0,"ANU","899","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[9291,"Col1a2-cre_ERFGFR1OP2floxed","C57Bl/6J-Tg<Col1a2-cre>-FGFR1OP2<tm1(floxed)>/AnuApb",null,"Recessive","FGFR1 oncogene partner 2","Fgfr1op2 ",null,"1500031J01Rik ","MGI:1914779 ","FGFR1 oncogene partner 2","Fgfr1op2 <tm1(floxed)>",null,"6",{"$nulls":16},"Col1a2-cre","Procollagen",{"$nulls":10},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-10-26","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Stuart","Pitson","University of South Australia","stuart.pitson@unisa.edu.au",{"$nulls":8},"No"]
[9293,null,"Adidas:Cahill:Ikbkb-V203I:GFP-Fox",null,"Dominant","only for L2 reder","only for L2 reder",{"$nulls":6},"Unknown",{"$nulls":28},"normal","normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-03",null,0,0,null,null,"true",null,"Chelisa","Cardinez","ANU","Chelisa.Cardinez@anu.edu.au",{"$nulls":3},"Nathalie","Doucet","nathalie.oucet@anu.edu.au",null,null,"No"]
[9294,"Juric:2","C57BL/6N-IL21R<em1>/AnuApb",null,"Semi-dominant","interleukin 21 receptor","IL21R",null,"NILR ","MGI:1890475","interleukin 21 receptor","IL21R<S489R>",null,"7",{"$nulls":28},"Normal","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-05","Cryopreserved sperm",45,0,"ANU",null,"true",null,"Matthew","Cook","Australian National University","matthew.cook@anu.edu.au",{"$nulls":3},"Kristy","Kwong","kristy.kwong@anu.edu.au",null,null,"No"]
[9278,"ENU53:G3","ANU:ENU53:G3",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2021-10-03","Cryopreserved sperm",80,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au",null,null,"No"]
[9267,"ENU54:G2","ANU:ENU54:G2",null,"Recessive","Unknown",{"$nulls":7},"Unknown",{"$nulls":15},"Unknown",{"$nulls":12},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",null,"1",null,"No","2021-08-23","Cryopreserved sperm",6704,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","Australian National university","apf.scientific.programs@anu.edu.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au",null,null,"No"]
[9239,"Itk:KO:10","C57BL/6N-Itk<em1Anu>/AnuApb",null,"Recessive","IL2 inducible T cell kinase","Itk",null,"Emt, Tcsk, Tsk","MGI:96621 ","Itk<em1Anu>AnuApb","Itk",null,"11",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-27","Cryopreserved sperm",12,0,null,null,"true",null,"Dominik","Spensberger","Australian National University","Dominik.Spensberger@anu.edu.au",{"$nulls":3},"Harish","Padmanabhan","Harish.Padmanabhan@anu.edu.au",null,null,"No"]
[9299,"Wnt11 KO","129:B6- Wnt11 <tm1Amc>",null,"Semi-dominant","wingless-type MMTV integration site family, member 11","Wnt11",null,null,"MGI:101948 ","wingless-type MMTV integration site family targeted mutation; Andrew McMahon","Wnt11 <tm1Amc>",null,"7",{"$nulls":28},"These mice display incomplete embryonic and perinatal lethality in a homozygous state with defects in kidney development","Normal, with slightly smaller kidneys","129S1/B6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-09","Cryopreserved sperm",50,0,null,null,"false",null,"Alexander","Combes","Monash University","alex.combes@monash.edu",{"$nulls":8},"No"]
[8833,null,"AMPK A2(S345A) KI",null,"Recessive","Prkaa2",{"$nulls":7},"Unknown",{"$nulls":28},"Normal","Normal","C57BL/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2019-12-10","Cryopreserved sperm",50,0,null,null,"true",null,"Jon","Oakhill","St Vincent's Institute of Medical Reserach","joakhill@svi.edu.au",{"$nulls":8},"No"]
[9172,"ENU53:G2","ANU:ENU53:G2",null,"Recessive","Not known yet",{"$nulls":7},"Unknown",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-04-08","Cryopreserved sperm",10829,0,"ANU",null,"false",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au",null,null,"No"]
[9295,null,"ASD663:Kennedy:4",null,"Dominant","BTLA",{"$nulls":4},"1bpInsertion",null,null,"Unknown",{"$nulls":28},"Normal","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-05","Cryopreserved sperm",60,0,null,null,"true",null,"Kristy","Kwong","Australian National University","kristy.kwong@anu.edu.au",{"$nulls":8},"No"]
[9296,null,"ASD663:Kennedy:6",null,"Dominant","BTLA",{"$nulls":4},"L188F",null,null,"Unknown",{"$nulls":28},"Normal","Normal","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-05","Cryopreserved sperm",58,0,null,null,"true",null,"Kristy","Kwong","Australian National University","kristy.kwong@anu.edu.au",{"$nulls":8},"No"]
[8834,"Nasp fl","C57BL/6N-Nasp<tm1c((EUCOMM)>/MarpApb",null,"Recessive","nuclear autoantigenic sperm protein (histone-binding)","Nasp","Unknown","5033430J04Rik, D4Ertd767e, Epcs32, Nasp-T","MGI:1355328","nuclear autoantigenic sperm protein (histone-binding); targeted mutation 1c, Wellcome Trust Sanger Institute","Nasp<tm1c(EUCOMM)Wtsi>",null,"4",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal",null,"C57BL/6N","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2019-12-11",null,0,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","phenbank@anu.edu.au",{"$nulls":8},"No"]
[9270,"Tg(mAce2-hACE2)","C57BL/6J<Tg(mAce2-hACE2)52MGMP>/AnuApb",null,"Recessive",{"$nulls":8},"Unknown",{"$nulls":16},"pAMP-mAce2 promoter-hACE2 cDNA-pA ","mouse Ace2 promoter","Unknown",{"$nulls":9},"Unknown","Unknown","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-09-17","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Jeanette","Rientjes","Monash Genome Modification Platform, Monash University","mgmp@monash.edu",{"$nulls":8},"No"]
[9115,"Drosha:CreER","B6:129-Drosha<tm1Litt>:Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/AnuApb",null,"Semi-dominant","drosha, ribonuclease type III","Drosha","Unknown","1110013A17Rik, Etohi2, Rnasen ","MGI:1261425","drosha, ribonuclease type III; targeted mutation 1, Dan R Littman","Drosha<tm1Litt>","http://www.informatics.jax.org/allele/key/61744","15",{"$nulls":16},"gene trap ROSA 26, Philippe Soriano; targeted mutation 9, TaconicArtemis","Gt(ROSA)26Sor",{"$nulls":10},"N/A","N/A","C57BL/6NTac:129P2/OlaHsd","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-11","Cryopreserved sperm",50,0,null,null,"false",null,"Mark","Chong","St Vincent's Institute of Medical Research","mchong@svi.edu.au",{"$nulls":8},"No"]
[5257,"CathepsinK.gp130fl/fl","C57BL/6-Il6st<tm1Wme> Ctsk<tm1(cre)Ska>",null,"Recessive","interleukin 6 signal transducer","Il6st","Normal","CD130, gp130","MGI:96560","interleukin 6 signal transducer; targeted mutation 1, Werner Mueller","Il6st<tm1Wme>","MGI:1931239","13",{"$nulls":15},"Yes",{"$nulls":12},"Unknown","Unknown","C57BL/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2010-10-21","Cryopreserved sperm",169,0,"St V",null,"false",null,"Natalie","Sims","St Vincent's Institute","nsims@svi.edu.au",{"$nulls":3},"Natalie","Sims","nsims@svi.edu.au","N/A","N/A","No"]
[5257,"CathepsinK.gp130fl/fl","C57BL/6-Il6st<tm1Wme> Ctsk<tm1(cre)Ska>",null,"Recessive","cathepsin K","Ctsk",null,"catK, Cat K","MGI:107823","cathepsin K; targeted mutation 1, Shigeaki Kato","Ctsk<tm1(cre)Ska>","MGI:3764465","3",{"$nulls":58},"Natalie","Sims","nsims@svi.edu.au","N/A","N/A"]
[8835,"ENU43:101:abcg8","C57BL/6NCrlAnu-Abcg8<m1Anu>/AnuApb",null,"Recessive","ATP binding cassette subfamily G member 8","Abcg8","Unknown","1300003C16Rik, Sterolin-2","MGI:1914720",{"$nulls":3},"17",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-12-12","Cryopreserved sperm",24,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","phenbank@anu.edu.au",{"$nulls":3},"Anna","Palkova","anna.palkova@anu.edu.au",null,null,"No"]
[9303,"Ntsr1-cre","C57BL/6J-Tg<(Ntsr1-cre)GN209Gsat>/AnuApb",null,"Semi-dominant","neurotensin receptor 1","Ntsr1",null,"NT-1R, NTR1, NTR-1, Ntsr1","MGI:97386",{"$nulls":3},"2",{"$nulls":16},"Cre recombinase","neurotensin receptor 1 gene",{"$nulls":10},"Unknown","Unknown","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-16","Live",0,0,"ANU",null,"false",null,"Greg","Stuart","Australian National University","Greg.stuart@anu.edu.au",{"$nulls":8},"No"]
[8055,"Sox2-GiDREADD","B6(Cg).129-Sox2<tm1(cre/ERT2)Hoch> Gt(ROSA)26Sor<tm1(CAG-CHRM4*,-mCitrine)Ute>/JAusb",null,"Recessive","SRY (sex determining region Y)-box 2","Sox2",null,"lcc, Sox-2, ysb","MGI:98364","SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger","Sox2<tm1(cre/ERT2)Hoch>","MGI:5295990","3",{"$nulls":28},"Bi-transgenic mice will enable expression of target gene (i.e. DREADD receptor) in sox2-expressing cells upon tamoxifen administration, which will persist as the cells differentiate and mature.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2016-06-03",null,0,0,"Moss Vale",null,"true",null,"Bryce","Vissel","Garvan Institute","bryce.vissel@garvan.org.au",{"$nulls":3},"Lyndsey","Konen","l.konen@garvan.org.au","N/A",null,"No"]
[8055,"Sox2-GiDREADD","B6(Cg).129-Sox2<tm1(cre/ERT2)Hoch> Gt(ROSA)26Sor<tm1(CAG-CHRM4*,-mCitrine)Ute>/JAusb",null,"Recessive","gene trap ROSA 26, Philippe Soriano","Gt(ROSA)26Sor",null,"beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1","MGI:104735","gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ute Hochgeschwender","Gt(ROSA)26Sor<tm1(CAG-CHRM4*,-mCitrine)Ute>","MGI:5614050","6",{"$nulls":58},"Lyndsey","Konen","l.konen@garvan.org.au","N/A"]
[9304,null,"ENU34:001:62b:Foxp3GFP:F9",null,"Dominant","only for L2 reder",{"$nulls":7},"Unknown",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-17",null,0,0,null,null,"true",null,"Cindy","Lee","ANU","Eunhee.Lee@anu.edu.au",{"$nulls":3},"Nathalie","Doucet","nathalie.oucet@anu.edu.au",null,null,"No"]
[9308,"Adar1 em2Crwy","C57Bl/6J-Adar1<em2Crwy>/AnuApb",null,"Semi-dominant","adenosine deaminase, RNA-specific","Adar",null,"ADAR1, Adar1p110, Adar1p150, mZaADAR ","MGI:1889575","adenosine deaminase, RNA-specific targeted mutation 2, Carl Walkley","Adar1<em2Crwy>",null,"3",{"$nulls":28},"Adar1 P195A mutation - homozygous P195A/P195A viable and fertile","heterozygous mice normal (both males and females)","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-26","Cryopreserved sperm",30,0,null,null,"false",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]
[9310,"mettl3 flox/flox","C57BL/6J-Mettl3<tm1Jhha>/AnuApb",null,"Semi-dominant","methyltransferase like 3","Mettl3 ",null,"2310024F18Rik, M6A, Spo8","MGI:1927165","methyltransferase like 3; targeted mutation 1, Jacob Hanna","Mettl3<tm1Jhha>","MGI:5911703","14",{"$nulls":30},"C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-12-01",null,0,0,"ANU",null,"false",null,"Si Ming","Man","Australian National University","siming.man@anu.edu.au",{"$nulls":8},"No"]
[9202,"C57BL/6J","ASD1136:C57BL/6JAusb.ANU:::EXP",null,"Dominant","N/A","N/A",{"$nulls":6},"Unknown",{"$nulls":28},"wildtype - normal","wildtype - normal","C57Bl6/J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-09",null,0,87,null,null,"true",null,"Nathalie","Doucet","ANU","nathalie.doucet@anu.edu.au",{"$nulls":3},"Nathalie","Doucet","nathalie.doucet@anu.edu.au",null,null,"No"]
[9182,null,"SwHel:Hc.Lc:Ly5a:Ptprca/NCrl",null,"Dominant","protein tyrosine phosphatase, receptor type","only for L2 reder",{"$nulls":6},"Unknown",{"$nulls":31},"Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-05-07",null,0,0,null,null,"true",null,"Pablo ","Fernandez De Canete Nieto ","ANU","pablo.fernandez@anu.edu.au",{"$nulls":8},"No"]
[9315,"Muscle mouse","C57BL/6.hcm",null,"Recessive","Unknown",null,"Unknown",{"$nulls":5},"Unknown",{"$nulls":28},"Spontaneous mutation arising in a C57BL/6 mouse colony that results in hypertrophic centronuclear myopathy and increased gross muscularity","unknown","C57Bl/6J","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",null,"4","brother-sister mating or first cousin mating","No","2021-12-07","Cryopreserved sperm",40,0,null,null,"true",null,"Thomas","Brodnicki","St Vincent's Institute","tbrodnicki@svi.edu.au",{"$nulls":3},"Thomas","Brodnicki","tbrodnicki@svi.edu.au",null,null,"No"]
[8837,"DNAH5/PKHD1","C57BL/6-Dnah5<em1Marp> Pkhd1<em1Marp>/Marp",null,"Recessive","dynein, axonemal, heavy chain 5","Dnah5","Unknown","b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo, Dnahc5, Mdnah5","MGI:107718",{"$nulls":3},"15",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-01-10","Cryopreserved sperm",50,0,"Monash",null,"true",null,"Ian","Smyth","Monash University","Ian.Smyth@monash.edu",{"$nulls":8},"No"]
[8837,"DNAH5/PKHD1","C57BL/6-Dnah5<em1Marp> Pkhd1<em1Marp>/Marp",null,"Recessive","polycystic kidney and hepatic disease 1","Pkhd1","Unknown","FPC, tigmin","MGI:2155808",{"$nulls":3},"1"]
[7966,"Heatr3 KO","C57BL/6NTac-Heatr3<tm1a(EUCOMM)Hmgu>/IcsOrlAnu","C57BL/6NTac-Heatr3<tm1a(EUCOMM)Hmgu>/IcsOrlAnu","Recessive","HEAT repeat containing 3","Heatr3","Normal","C030036P15Rik","MGI:2444491","HEAT repeat containing 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH","Heatr3<tm1a(EUCOMM)Hmgu>","MGI:4435825","8",{"$nulls":28},"Normal","Normal","C57BL/6NTac","Unknown","Yes","Yes","Unknown","Yes","Yes","No","Unknown",{"$nulls":3},"No","2015-09-04","Cryopreserved sperm",31,0,"ANU","1067","false",null,"Ross","Hannan","The Australian National University","ross.hannan@anu.edu.au",{"$nulls":3},"Amee","George","amee.george@anu.edu.au","N/A","NA","No"]
[9216,"Irf4:F0:23","C57BL/6NCrlAnu-Ifr4<em1Anu>/AnuApb",null,"Semi-dominant","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip","MGI:1096873 ","Irf4<em1(APF)PTF>","Irf4:F0:23",null,"13",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-07","Cryopreserved sperm",12,0,"ANU",null,"true",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":3},"Rachel ","Milne","rachel.milne@anu.edu.au",null,null,"No"]
[8838,"ENU46:327:Casp1","C57BL/6NCrlAnu-Casp1<m4Anu>/AnuApb",null,"Recessive","caspase 1","Casp1","Unknown","Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme","MGI:96544",{"$nulls":3},"9",{"$nulls":28},"Unknown",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-01-14","Cryopreserved sperm",72,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8843,"Rab30 CRISPR KO #4","C57BL/6-Rab30<em1>/Apb",null,"Recessive","RAB30, member RAS oncogene family","Rab30","Unknown","5033421K01Rik","MGI:1923235",{"$nulls":3},"7",{"$nulls":28},"Normal","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-01-23","Cryopreserved sperm",50,0,null,null,"true",null,"Paul","Gleeson","University of Melbourne","paul.gleeson@unimelb.edu.au",{"$nulls":8},"No"]
[9318,"Irf4:K123R    ","C57BL/6NCrl-Irf4<em8Anu>/Anu",null,"Dominant","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip ","MGI:1096873","endonuclease mediated targeting 8; Anselm Enders","Irf4 <K123R>",null,"13",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-12-13","Cryopreserved sperm",54,0,null,null,"true",null,"Anselm","Enders","Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[9354,"ENU43:055:B6:G2rN1","C57BL/6Ncrl:ENU43<G2rN1>/Anu",null,"Dominant","Unknown",{"$nulls":7},"Unknown",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-03-13","Cryopreserved sperm",32,0,null,null,"true",null,"Anna","Palkova","APF","anna.palkova@anu.edu.au",{"$nulls":8},"No"]
[8848,"ENU47:327:Casp4","C57BL/6NCrlAnu-Casp4<m3Anu>/AnuApb",null,"Recessive","caspase 4, apoptosis-related cysteine peptidase","Casp4","Unknown","Casp11, Caspase-11, ich-3","MGI:107700",{"$nulls":3},"9",{"$nulls":28},"Unknown","Unknown","C57BL/6NCrlAnu","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2020-02-06","Cryopreserved sperm",92,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8866,"129X1/SvJ:B6   ; Casp11<129>","B6NCrlAnu;129X1-Casp4<del>/AnuApb",null,"Recessive","caspase 4, apoptosis-related cysteine peptidase","Casp4","Nil","Casp11, Caspase-11, ich-3","MGI:107700","caspase 4, apoptosis-related cysteine peptidase; deletion","Casp4<del>","MGI:5473345","9",{"$nulls":28},"Mice exhibited defects in IL-1β production and harboured a mutation in the Casp11 locus that attenuated caspase-11 expression.Caspase-11 rather than caspase-1, however, was required for non-canonical inflammasome-triggered macrophage cell death, indicating that caspase-11 orchestrates both caspase-1-dependent and -independent outputs. Caspase-1 activation by non-canonical stimuli required NLRP3 and ASC, but caspase-11 processing and cell death did not, implying that there is a distinct activator of caspase-11. Lastly, loss of caspase-11 rather than caspase-1 protected mice from a lethal dose of lipopolysaccharide.",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-02-24",null,0,0,"ANU",null,"true",null,"The Australian","Phenomics Facility","Australian National University","apf.scientific.programs@anu.edu.au",{"$nulls":8},"No"]
[8886,"ASD941:TCF7-GFP","C57BL/6-Tcf7<tm1Hhx>/HhxAnuApb",null,"Recessive","transcription factor 7, T cell specific","Tcf7",null,"T cell factor-1, T-cell factor 1, Tcf1, TCF-1","MGI:98507","transcription factor 7, T cell specific; targeted mutation 1, Hai-Hui Xue","Tcf7<tm1Hhx>","MGI:5805838","11",{"$nulls":28},"Using newly-generated Tcf7GFP reporter mice, we identified novel early innate lymphoid progenitors that express high levels of TCF-1 but lack surface markers of adaptive and innate lymphocyte lineages. These early innate lymphoid progenitors closely resemble bone marrow lymphoid progenitors at the transcriptome level, but lack efficient T and B lymphocyte potential. Instead, they efficiently gave rise to various ILC lineages, including conventional NK cells as well as cytokine-producing helper ILC at the clonal level, indicating that they are the earliest identifiable ILC progenitors. ","Normal","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-13","Cryopreserved sperm",33,0,"ANU","941","true",null,"Qian","Shen","Australian National University","qian.shen@anu.edu.au",{"$nulls":8},"No"]
[9321,"ASD953:Bake:1","C57BL/6NCrlAnu-Zfp64em1Anu Zfp64em2Anu/Anu",null,"Semi-dominant","zinc finger protein 64","ZFP64",null,null,"MGI:107342 ",{"$nulls":3},"2",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-12-16","Cryopreserved sperm",52,0,null,null,"true",null,"Matthew","Cook","JCSMR/ANU","matthew.cook@anu.edu.au",{"$nulls":8},"No"]
[9341,null,"C57BL/6-Myo1f<em1.1(flox)>/HaqueWehi",null,"Dominant","myosin IF","Myo1f",null,null,"MGI:107711",{"$nulls":3},"17",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-02-22","Cryopreserved sperm",50,0,null,null,"false",null,"Ashraful","Haque","University of Melbourne","ashraful.haque@unimelb.edu.au",{"$nulls":8},"No"]
[9339,"Matk cKO","C57BL/6J-Matk<em1>/HaqueWehi",null,"Semi-dominant","megakaryocyte-associated tyrosine kinase","Matk",null,"CHK, Csk homologous kinase, HYL, Ntk ","MGI:99259 ","Matk<em1>","Matk cKO",null,"Unknown","NCBI Gene: 17179",{"$nulls":27},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-02-22","Cryopreserved sperm",50,0,"WEHI",null,"false",null,"Ashraful","Haque","University of Melbourne","ashraful.haque@unimelb.edu.au",{"$nulls":8},"No"]
[9338,"Akirin F0:60","C57BL/6NCrlAnu-Akirin<em4>/AnuApb",null,"Semi-dominant","akirin 1","Akirin1 ","Unknown","6330407G11Rik","MGI:1915300 ","endonuclease mediated targeting 4;","Akirin F0:#60",null,"4",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-02-21","Cryopreserved sperm",10,0,null,null,"true",null,"Dominik","Spensberger","ANU","Dominik.Spensberger@anu.edu.au",{"$nulls":8},"No"]
[8929,"CD23cre","B6.Cg-Tg(Fcer2a-cre)5Mbu/JMarpAnuApb",null,"Dominant",{"$nulls":25},"transgene insertion 5, Meinrad Busslinger","Fcer2a",{"$nulls":10},"These Cd23-cre transgenic mice express cre under the control of the Fcer2a promoter. Cre recombinase expression is detected in immature, transitional and late B cells in the bone marrow and spleen. Mice that are hemizygous for the transgene are viable and fertile.","These Cd23-cre transgenic mice express cre under the control of the Fcer2a promoter. Cre recombinase expression is detected in immature, transitional and late B cells in the bone marrow and spleen. Mice that are hemizygous for the transgene are viable and fertile.","C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-03-27","Cryopreserved sperm",17,18,"ANU",null,"false",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[9287,"Fancl:del336_337-Adh5:del448bp","C57Bl/6J-Fancl<em1(del336_337)>-Adh5<em1(del448bp)>/AnuApb",null,"Semi-dominant","Fanconi anemia, complementation group L ","Fancl ","Unknown","2010322C19Rik, B230118H11Rik, gcd, Phf9, Pog ","MGI:1914280","Fanconi anemia, complementation group L ","Fanl<em1(dele336_337)>",null,"11",{"$nulls":28},"Mice homozygous for Fancl present microphtalmia in one or both eyes, slightly reduced size when young, and infertility.Mice homozygous for  Adh5 present increased susceptibility to various toxins, and abnormal blood pressure regulation under anaesthesia.","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-10-18","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Richard","Dandrea","University of South Australia","richard.dandrea@unisa.edu.au",{"$nulls":8},"No"]
[9287,"Fancl:del336_337-Adh5:del448bp","C57Bl/6J-Fancl<em1(del336_337)>-Adh5<em1(del448bp)>/AnuApb",null,"Semi-dominant","Alcohol dehydrogenase 5 (class III), chi polypeptide","Adh5",null,"Adh3, Adh-5, GSNOR, S-nitrosoglutathione reductase ","MGI:87929","Alcohol dehydrogenase 5 (class III), chi polypeptide","Adh5<em1(del448bp)>",null,"Unknown"]
[4078,"Frink ; ENU6PH:052 ","C;B6JAnu-Irf4<m1Anu>/AnuApb",null,"Recessive","interferon regulatory factor 4","Irf4",null,"IRF-4, Spip","MGI:1096873","Frink",null,null,"13","ENSMUSG00000021356","ENSMUST00000021784","Irf4-001","332","434","T to A","ENSMUSE00000117279","3","111","Valine to Aspartic acid",{"$nulls":4},"GAACAAGAGCAATGACTTTGAGGAATTGGTCGAGAGGAGCCAGCTGGATATCTCTGACCCA","Yes",{"$nulls":12},"Hypo IgE response following allergic challenge.Panhypogamma.",null,"C57BL/6 x BALB/b","Yes","Yes","Yes","Yes","Yes","Yes","No","Poor",{"$nulls":3},"No","2008-12-04","Cryopreserved sperm",195,0,"ANU",null,"false",null,"Matthew","Cook","The Australian National University","matt.cook@anu.edu.au",{"$nulls":3},"Geoff","Sjollema","geoff.sjollema@anu.edu.au","N/A","N/A","No"]
[9365,null,"B6.129P-Mgea5tm 2 Jah/NIDDK",null,"Semi-dominant","O-GlcNAcase (OGA / Mgea5)","Oga",null,null,"MGI:1932139",{"$nulls":3},"19",{"$nulls":9},"Unknown to Unknown",{"$nulls":18},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-03-24","Cryopreserved sperm",50,0,null,null,"false",null,"Nishma","Gupta","University of Melbourne","guptan@unimelb.edu.au",{"$nulls":8},"No"]
[9297,"Robo2 KO","C57Bl/6J-Robo2<em1Mon>/AnuApb",null,"Semi-dominant","Roundabout guidance receptor 2","Robo2","Unknown","2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568","MGI:1890110","Roundabout guidance receptor 2","Robo2<em1Mon>",null,"16",{"$nulls":28},"Homozygous mice have duplex kidneys during development. Adult phenotype unknown for this line.","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-11-08","Cryopreserved sperm",50,0,"Monash",null,"false",null,"Alexander","Combes","Monash University","alex.combes@monash.edu.au",{"$nulls":8},"No"]
[9319,"Arap2 P1233S:8","C57BL/6NCrlAnu-Arap2<em1>/AnuApb",null,"Semi-dominant","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2","Arap2",null,"Centd1, mKIAA0580","MGI:2684416","endonuclease mediated targeting 1; Anselm Enders","Arap2 <P1233S> ",null,"5",{"$nulls":28},"Unknown","Unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-12-13","Cryopreserved sperm",54,0,null,null,"true",null,"Anselm","Enders","Australian National University","anselm.enders@anu.edu.au",{"$nulls":8},"No"]
[9369,"Rara:F0:Indel","C57BL/6NCrlAnu-Rara<em1>/AnuApb",null,"Semi-dominant","retinoic acid receptor, alpha","Rara","Unknown","RARalpha1, RAR alpha 1 ","MGI:97856","Rara<em1>","Rara:F0:Indel",null,"11",{"$nulls":28},"unknown","unknown","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-04-06","Cryopreserved sperm",19,0,null,null,"true",null,"Matthew","Cook","JCSMR","matthew.cook@anu.edu.au",{"$nulls":3},"Rachel","Milne","rachel.milne@anu.edu.au",null,null,"No"]
[9353,"Asap1 Floxed","C57BL/6-Asap1<em2>/Wehi",null,"Semi-dominant","ArfGAP with SH3 domain, ankyrin repeat and PH domain1","Asap1","Unknown","Ddef1, mKIAA124","MGI:1342335 ","endonuclease mediated targeting 2; Ashraful Haque","Asap1<em2>",null,"15",{"$nulls":28},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-03-10","Cryopreserved sperm",50,0,null,null,"false",null,"Ashraful","Haque","University of Melbourne","ashraful.haque@unimelb.edu.au",{"$nulls":8},"No"]
[9344,"Tbc1d4 Floxed","C57BL/6-Tbc1d4<em1.1(flox)>/Wehi",null,"Semi-dominant","TBC1 domain family, member 4","Tbc1d4","Unknown","5930406J04Rik, AS160 ","MGI:2429660","endonuclease mediated targeting 1.1; Ashraful Haque","Tbc1d4",null,"14",{"$nulls":28},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-02-24","Cryopreserved sperm",50,0,null,null,"true",null,"Ashraful","Haque","University of Melbourne","ashraful.haque@unimelb.edu.au",{"$nulls":8},"No"]
[9192,"Wdr1rd/rd","C57BL/6- Wdr1<tm1Wehi>/ApbAnu",null,"Semi-dominant","WD repeat domain 1","Wdr1",null,"Aip1, D5Wsu185e, rede ","MGI:1337100","Wdr1<tm1Wehi>","Wdr1 rd/rd",null,"5",{"$nulls":28},"Homozygous mice begin to develop inflamed ears after ~100 days of age. The inflammation at the ears emerge in ‘pockets’ at the tip of the ears and as the mice age, the ears will have redness and oedema with immune infiltration. The inflammation at the tail would also emerge in pockets throughout the tail, though most prominently at the tip of the tail. As the mice age, the tail will become hardened and inflamed.","unknown","C57BL/6 “The rd mutation was induced on an inbred C57BL/6 background, isolated on a mixed C57BL/6J: 129S6/SvEv:C3HeB/FeJ background,38 and back-crossed 10 generations to C57BL/6.” (Kile et al., 2007, Blood, PMID: 17515402)","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-01","Cryopreserved sperm",50,0,null,null,"false",null,"Patrick","Bertolino",null,"p.bertolino@centenary.org.au",{"$nulls":8},"No"]
[9352,"Myo1f flox","C57BL/6-Myo1f<em2(flox)>/HaqueWehi",null,"Recessive","myosin IF","Myo1f",null,"C330006B10Rik","MGI:107711","Myo1f<em2(flox)>","Myo1 flox",null,"17",{"$nulls":28},"Normal","Normal","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-03-10","Cryopreserved sperm",50,0,null,null,"false",null,"Ashraful","Haque","University of Melbourne","ashraful.haque@unimelb.edu.au",{"$nulls":8},"No"]
[9176,"Zic5R <K363R> (Kiska; Ki)","C57BL/6J Zic5R <tm1Anu>/ApbAnu",null,"Recessive","zinc finger protein of the cerebellum 5","Zic5",null,"1700049L20Rik, odd-paired related, Opr ","MGI:1929518","Zic5<tm1Anu>","K363R (Kiska; Ki)",null,"14",{"$nulls":28},"This hypomorphic allele of Zic5 leads to hypoplasia of the neural crest. This leads to a small proportion of homozygous animals will develop hydrocephaly post birth (5%). Homozygous animals also are more likely to have a ventral spot/colour change on their coat or line of white hair (13%) compared with heterozygous animals (3%).  ","A small proportion of heterozygous animals have a ventral spot/colour change on their coat or line of white hair (3%). ","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-04-27","Cryopreserved sperm",57,0,"ANU",null,"false",null,"Ruth","Arkell","Australian National Univeristy","ruth.arkell@anu.edu.au",{"$nulls":8},"No"]
[9208,"ENU50:073","C57BL/6Ncrl<ENU50>/ApbAnu",null,"Semi-dominant","reticuloendotheliosis oncogene","Rel",null,"c-Rel","MGI:97897",{"$nulls":3},"11",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-06-25","Cryopreserved sperm",22,0,null,null,"true",null,"Anna","Palkova","APF","anna.palkova@anu.edu.au",{"$nulls":8},"No"]
[9208,"ENU50:073","C57BL/6Ncrl<ENU50>/ApbAnu",null,"Semi-dominant","dynein axonemal assembly factor 10","Dnaaf10 ",null,"Wdr92 ","MGI:2144224",{"$nulls":3},"11"]
[9232,"ENU50:129","C57BL/6Ncrl<ENU50>/AnuApb",null,"Semi-dominant","Not known yet",{"$nulls":7},"Unknown",{"$nulls":30},"C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-07-26","Cryopreserved sperm",12,0,null,null,"true",null,"Anna","Palkova","APF","anna.palkova@anu.edu.au",{"$nulls":8},"No"]
[9122,"Adh5-48","C57Bl6/J<em1UniSA>/ApbAnu",null,"Semi-dominant","alcohol dehydrogenase 5 (class III), chi polypeptide","Adh5","Unknown","Adh3, Adh-5, GSNOR, S-nitrosoglutathione reductase","MGI:87929",{"$nulls":3},"3",{"$nulls":28},"Homozygotes might be susceptible to endotoxic shock and low blood pressure under anaesthesia.","Normal.","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-01-19","Cryopreserved sperm",50,0,null,null,"true",null,"Richard","D","University of South Australia","richard.dandrea@unisa.edu.au",{"$nulls":8},"No"]
[9361,"Bsn A353T","C57BL/6NCrl-Bsn<em1Anu>/ApnAnu",null,"Semi-dominant","bassoon","Bsn",null,"presynaptic cytomatrix protein ","MGI:1277955 ","endonuclease mediated targeting 1; Carola Vinuesa","Bsn<A353T>",null,"9",{"$nulls":28},"May develop epilepsy","May develop epilepsy","C57Bl/6N","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2022-03-18","Cryopreserved sperm",20,0,null,null,"true",null,"Carola","Vinuesa",null,"Carola.Vinuesa@anu.edu.au",{"$nulls":8},"No"]
[9147,"MR1-K43A/MR1-Tom","C57BL/6J Mr1<(em1)UniMel>Mr1<(tm1)UniMel>/ApbAnu",null,"Semi-dominant","major histocompatibility complex, class I-related","Mr1",null,"H2ls, MR1 ","MGI:1195463","Mr1; endonuclease mutation 1, Hamish McWilliam","Mr1<K43A> mutant",null,"1",{"$nulls":16},"Tandem dimer Tomato","Mr1 endogenous promoter","Unknown",{"$nulls":9},"Normal","Normal","C57Bl/6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-02-16","Cryopreserved sperm",50,0,null,null,"true",null,"Hamish","McWilliam","The Doherty Institute, the University of Melbourne","hamish.mcwilliam@unimelb.edu.au",{"$nulls":8},"No"]
[9186,"Marchf8 KO","C57BL6/J-Marchf8<em1(WEHI)>",null,"Semi-dominant","membrane-associated ring finger (C3HC4) 8","Marchf8 ",null,"1300017E09Rik, March8, Mir","MGI:1919029","endonuclease mediated targeting 1; Haiyin Liu","Marchf8 KO",null,"6",{"$nulls":28},"Marchf8 K.O. mice have enriched surface expression of MHC II in thymic epithelial cells compared to WT mice","The same as homozygous K.O. but to a lesser extent","C57Bl/6J","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2021-05-13","Cryopreserved sperm",50,0,null,null,"true",null,"Haiyin","Liu","The University of Melbourne","haiyin.liu@unimelb.edu.au",{"$nulls":8},"No"]
[9020,"Scn2a R853Q","C57BL/6-Scn2a <em1(R853Q)>/Apb",null,"Recessive","Scn2a","NCBI Gene: 110876",null,"A230052E19Rik, Nav1.2, Scn2a1","MGI:98248",{"$nulls":3},"2","ENSMUSG00000075318","ENSMUST00000028377.13","Scn2a-201",{"$nulls":25},"Not born","No obvious behavioural phenotype or health issue","C57Bl6","Unknown","Unknown","Unknown","Unknown","Unknown","Unknown","No","Unknown",{"$nulls":3},"No","2020-06-23","Cryopreserved sperm",50,0,null,null,"true",null,"Lynley","Cordeiro","The Florey Institute of Neuroscience and Mental Hea","lynley.cordeiro@florey.edu.au",{"$nulls":3},"Lynley","Cordeiro","lynley.cordeiro@florey.edu.au",null,null,"No"]
[9035,"Dazzler","C57BL/6NCrlAnu-Nrn1<em1Anu>/AnuApb",null,"Dominant","neuritin 1","Nrn1",null,"0710008J23Rik, cpg15","MGI:1915654",{"$nulls":3},"13",{"$nulls":28},"Normal",null,"C57BL/6NCrlAnu","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2020-06-26","Cryopreserved sperm",55,0,"ANU","727","true",null,"Carola","Vinuesa","Australian National University","carola.vinuesa@anu.edu.au",{"$nulls":8},"No"]
[8604,"Abca4 KO:Rdh8 KO","B6;129-Abca4<tm1Ght> Rdh8<tm1Kpal>/JAnuApb",null,"Recessive","ATP-binding cassette, sub-family A (ABC1), member 4","Abca4","Nil","Abc10, D430003I15Rik, Rim protein, RmP ","MGI:109424","ATP-binding cassette, sub-family A (ABC1), member 4; targeted mutation 1, Gabriel H Travis","Abca4<tm1Ght>","MGI:1857860","3",{"$nulls":28},"Retinal neovascularization:\t• Choroidal Neovascularization (CNV) in 22.2% (2/9) of the eyes• no Choroidal Neovascularization (CNV) in the eyes of sirolimus-treated mice.Abnormal retinal photoreceptor morphology.Decreased retinal photoreceptor cell number:\t• reduced number of photoreceptor nuclei along the inferior retinal regions and severe retinal degeneration at 5 months and 10 months of age, respectively.Decreased retinal cone cell number:• reduced number of cone photoreceptors• retinylamine treatment largely preserve cone photoreceptors• antioxidant, 9cRAc, and sirolimus treatment preserve cone photoreceptors, but not as well as retinylamine.Abnormal retinal pigment epithelium morphology:\t• swollen retinal pigment epithelium (RPE) with increased pigmented granules that included lipofuscin in mice kept in room light at 5 months of age• disrupted inner membrane cristae in RPE cells at 5 months of age• dead RPE cells lacking mitochondrial inner membrane cristae at 10 months of age.Abnormal retinal pigmentation:• increased pigmented granules that included lipofuscin in mice kept in room light at 5 months of age• di-retinoidpyridinium-ethanolamine (A2E) accumulation• retinylamine significantly decreased A2E accumulation.Thin retinal outer nuclear layer:• severely reduced outer nuclear layerRetinal degeneration:\t• early retinal degeneration is detected by 6 to 8 weeks of age in mice kept in dim room light (3-5 lux)• reduced lengths of photoreceptor outer segments (less than 5 micrometers)• antioxidant, 9cRAc, retinylamine and sirolimus treatment have efficacy in preventing retinal degeneration.Retinal deposits:• hyaline-like deposits in the rosette structure in 3- to 5-month-old mutant miceAbnormal Bruch membrane morphology:• complement deposition on Bruch's membrane• reduced complement deposition in antioxidant, 9cRAc, and sirolimus-treated mice• no complement deposition in retinylamine-treated mice.Abnormal eye electrophysiology.\tAbnormal cone electrophysiology:• reduced a- and b-wave amplitudes• both a- and b-wave amplitudes are maintained significantly better in antioxidant, 9cRAc, retinylamine and sirolimus-treated mice.Abnormal rod electrophysiology:• reduced Flicker ERG responses• responses of some antioxidant- and 9cRAc-treated mice are significantly retained after both 20- and 30-Hz stimuli",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2018-11-14","Cryopreserved sperm",50,0,"ANU",null,"true",null,"Riccardo","Natoli","The Australian National University","riccardo.natoli@anu.edu.au",{"$nulls":8},"No"]
[8604,"Abca4 KO:Rdh8 KO","B6;129-Abca4<tm1Ght> Rdh8<tm1Kpal>/JAnuApb",null,"Recessive","retinol dehydrogenase 8","Rdh8","Nil","LOC235033, prRDH","MGI:2685028","retinol dehydrogenase 8; targeted mutation 1, Krzysztof Palczewski","Rdh8<tm1Kpal>","MGI:3586327","9"]
[8718,"FANCM KO","FVB-Fancm<em2>/StVApb",null,"Recessive","Fanconi anemia, complementation group M","Fancm","Nil","C730036B14Rik, D12Ertd364e","MGI:2442306",{"$nulls":3},"11",{"$nulls":28},"Reduced fertility: smaller testis and epidydmis. Reduced sperm count and sperm motility.May have decreased lifespan.May have increased cancer susceptibility.","May have increased cancer susceptibility.","FVB/N","Unknown","Unknown","Yes","Unknown","Unknown","Yes","No","Unknown",{"$nulls":3},"No","2019-05-23","Cryopreserved sperm",50,0,"St V",null,"true",null,"Wayne","Crismani","St Vincent's Institute","wcrismani@svi.edu.au",{"$nulls":8},"No"]
[1858,"Eu-myc/mOVA","C57BL/6-Tg(IghMyc)22Bri Tg(act-mOVA)",null,"Dominant",{"$nulls":25},"transgene insertion 22, Ralph L Brinster","Lymphoid-specific immunoglobulin heavy chain enhancer (Eμ)","B cell lineage",{"$nulls":10},"Phenotype expected to be similar to parental Emu-myc line. These mice will develop high incidence pre-B and B lymphoma. More than 90% of Emu-myc mice die between 6 and 18 weeks of age (median 11 weeeks). Enlargement of all lymph nodes, spleen, infiltration of thymus (thymoma), bone marrow, liver, lung, weight loss. Further more, these mice will express ubiquitously the membrane bound chicken ovalbumin under the chicken beta - actin promoter.  MICE WILL BE MONITORED BY PALPATION OF LYMPH NODES AND SPLEEN 3X/WEEK.  act-mOVa are on a C57BL/6 background. Homozygous breeding considerably less productive than heterozygous   B6 myc: excess pre - B cells in bone marrow.",null,"Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",null,null,"Mate - transgenic males with wild type B6 females","No","2007-08-10",null,0,0,null,"WEHI #1676","false",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[{"$nulls":30},"membrane bound ovalbumin","actin"]
[1860,"Mcl-1flox/Bak/Bax knockout","Un-Mcl1<tm3Sjk> Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","myeloid cell leukemia sequence 1","Mcl1","Normal","Mcl-1","MGI:101769","targeted mutation 3, Stanley J Korsmeyer","Mcl1<tm3Sjk>","MGI:2684151","3",{"$nulls":15},"Yes",{"$nulls":12},"Mcl-1 - No -/- offsrping as -/- blastocysts die at E4 prior to implanation. Therefore only +/+ and +/-  which are completely normal. Mice lacking bax display limited phenotypic abnormalities. Bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis. Those that survive are runted and grey.",null,null,"No","No","Yes","No","No","Yes","No","Unknown",{"$nulls":3},"No","2007-08-10",null,0,0,null,"WEHI #2005","false",null,"Andreas","Strasser","Walter and Eliza Hall Institute of Medical Research","strasser@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[1860,"Mcl-1flox/Bak/Bax knockout","Un-Mcl1<tm3Sjk> Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","BCL2-antagonist/killer 1","Bak1","Nil","Bak, N-Bak","MGI:1097161","BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson","Bak1<tm1Thsn>","MGI:2159364","17",{"$nulls":61},"N/A","N/A"]
[1860,"Mcl-1flox/Bak/Bax knockout","Un-Mcl1<tm3Sjk> Bak1<tm1Thsn> Bax<tm1Sjk>/Wehi",null,"Recessive","Bcl2-associated X protein","Bax","Nil",null,"MGI:99702","BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer","Bax<tm1Sjk>","MGI:1857429","7",{"$nulls":61},"N/A","N/A"]
[4789,null,"BALB/c",null,"Dominant",{"$nulls":37},"Normal.",null,"Balb/cJ","Yes","Yes","Yes","Yes","Yes","Yes","No","Good",{"$nulls":3},"No","2009-09-06",null,0,0,null,null,"false",null,"The Australian","Phenomics Facility","The Australian National University","stuart.read@anu.edu.au",{"$nulls":3},"Stuart","Read","stuart.read@anu.edu.au","A.BS.01.09","N/A","No"]
[1825,"PUT/Mxcre","C57BL/6-Sfpi1<tm1.2Nutt> Tg(Mx1-cre)1Cgn",null,"Recessive","SFFV proviral integration 1","Sfpi1","Unknown","Dis-1, PU.1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1","MGI:98282","targeted mutation 1.2, Stephen L Nutt","Sfpi1<tm1.2Nutt>","MGI:3578011","2",{"$nulls":15},"Yes","transgene insertion 1, University of Cologne","Inducible MX1",{"$nulls":10},"Prior to PolyIC treatment the phenotype is the same as wild type phenotype of the same genetic background. After polyIC treatment (ie after the deletion of PU.1 gene) mice exhibit transient weight loss, which sometimes can be sever (more than 10%) and splenomegaly. Myeloid leukaemia development in average 6 months after polyIC treatment.Absent erythrocytes: bone marrow lacked the nucleated erythroid cells that represent 17% of the control bone marrow.Decreased B cell number: B lymphocyte numbers were reduced variably in the bone marrow, with most cells having a preB cell phenotype.Increased granulocyte number: expansion of granulocyte precursors in the bone marrow and spleen.Abnormal granulocyte differentiation: granulocytes maintained c-kit expression and displayed some, but not complete, maturation.Extramedullary hematopoiesis: spleen cells generated vastly increased numbers of granulocytic colonies, excessive numbers of megakaryocytic colonies and IL-3 responsive macrophage-containing colonies.Abnormal bone marrow cell morphology/development: the bone marrow contained normal total cellularity but exhibited an increased proportion of blast cells, and immature cells of the granulocyte lineage (promyelocytes and myelocytes).Absent common myeloid progenitor cells:* bone marrow lacked eosinophil colony-forming cells that were responsive to granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 or IL-5, but had greatly elevated numbers of granulocytic colonies developed when stimulated by G-CSF, IL-3 or stem cell factor but not with IL-6.* few or no megakaryoctye colonies developed in cultures of bone marrow cells under optimal culture for megakaryoctye formation.* loss of any readily identifiable lymphoid and myeloid progenitor or stem cell populations.Abnormal spleen morphology: in severe cases, spleen showed homogeneous infiltration by immature granulocytic forms and loss of splenic architecture.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2007-08-06",null,0,0,null,"WEHI #1091","false",null,"Stephen","Nutt","Walter and Eliza Hall Institute of Medical Research","nutt@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[3406,"act-mOVA / MHCII I-Ab -/-","C57BL/6-H2-Ab1<tm1> Tg(CAG-OVA)916Jen/Wehi",null,"Recessive","histocompatibility 2, class II antigen A, beta 1","H2-Ab1","Unknown","A beta, Abeta, H-2Ab, H2-Ab, I-Ab, I-Abeta, Ia-2, Ia2, IAb, Rmcs1","MGI:103070",{"$nulls":3},"17",{"$nulls":15},"Yes","transgene insertion 916, Marc K Jenkins","chicken β-actin",{"$nulls":10},"Ubiquitously express membrane bound chicken ovalbumin under the control of chicken β-actin promoter. Breed less well than hets.   Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.",null,"C57BL/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Unknown",{"$nulls":3},"No","2008-07-13",null,0,0,null,"WEHI #101","true",null,"William","Heath","Walter and Eliza Hall Institute of Medical Research","heath@wehi.edu.au",{"$nulls":6},"N/A","N/A","No"]
[9053,"R26-LSL-Adar1p110","C57BL/6-Gt(ROSA)26Sor<tm2(Adar1p110)Cwa>/CwaApb ",null,"Recessive","Gene trap ROSA 26","Rosa26 / Adar1",null,null,"104735","C57BL/6-Gt(ROSA)26Sor<tm2(Adar1p110)Cwa>/CwaApb",null,null,"6",{"$nulls":16},"Adenosine Deaminase RNA specific","R26 endogenous","Moderate to low",{"$nulls":9},"Normal - Lox-stop-lox KI of Adar1p110 into Rosa26 locus; requires Cre to express","Normal - Lox-stop-lox KI of Adar1p110 into Rosa26 locus; requires Cre to express","C57Bl/6","Yes","Yes","Yes","Yes","Yes","Yes","No","Good","Unknown",null,"Unknown","No","2020-08-06","Cryopreserved sperm",40,0,null,null,"true",null,"Carl","Walkley","St Vincent's Institute","cwalkley@svi.edu.au",{"$nulls":8},"No"]