A targeting vector was designed to flank exon 4 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the frt-flanked neo cassette. (J:101977)
Location on chromosome (bp):
7556978-7592224 bp
MGI Gene Accession ID
Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)
A targeting vector was designed to flank exon 5 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the neo cassette. (J:101977)
Location on chromosome (bp):
57927119-57983669 bp
MGI Gene Accession ID
Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)
The following elements were inserted into the locus: the CAG promoter, a loxP site, a neomycin resistance gene cassette, a STOP cassette (four poly(A) signal sequences), a second loxP site, a mutated human yes-associated protein 1 cDNA (where all five serine codons were changed to alanine to create a constitutively active form of the encoded peptide) with 5' in-frame FLAG tag and NLS coding sequence, an IRES, and the lacZ beta galactosidase reporter gene. Only after cre-mediated removal of the neo-STOP cassette will this locus express the YAP1 and lacZ genes
* Hemizygote as used here refers to males carring a mutation on the X chromosome or mice of either sex
carrying an inserted transgene with no homologous allele on the other chromosome.
Homozygous Matings Required?
No
Male Fertility Compromised?
No
Breeding Performance
Unknown
Relevant bibliographic / database references
General information
Associated IP rights?
Unknown
Does it Model a Human Condition?
Unknown
Is the strain available in any form to other researchers
