Home - Australian Phenome Bank

Mouse Strain information

APB ID

10407

Added

07/03/2024

Last Edited

03/06/2024

Strain nomenclature:

C57BL/6CrlAnu-5(Gbp8-Gbp4-Gbp9)em1Anu

Nickname:

Wheat

Genetics

Strain Types

Mutant stock

Genetic Details

CRISPR targeted

Mode of Inheritance

Recessive

1. Affected Gene Name: guanylate-binding protein 8

Chromosome	5
Affected Gene Symbol	Gbp8
Location on chromosome (bp):	105160379-105201475 bp
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:1923324
Ensembl Gene ID:	ENSMUSG00000034438

2. Affected Gene Name: guanylate binding protein 4

Chromosome	5
Affected Gene Symbol	Gbp4
Location on chromosome (bp):	105263633-105287452 bp
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:97072
Ensembl Gene ID:	ENSMUSG00000079363

3. Affected Gene Name: guanylate-binding protein 9

Chromosome	5
Affected Gene Symbol	Gbp9
Location on chromosome (bp):	105224332-105258255 bp
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:3605620
Ensembl Gene ID:	ENSMUSG00000029298

Knockout details:

5(Gbp8-Gbp4-Gbp9):endonuclease-mediated mutation 1, Australian National University: 127kbdeletion

Point mutation sequence:

Insertion/Tagging details:

Guide(s) RNA sequence:

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Normal

Phenotype Heterozygous State

Normal

Strain identification

How is this strain characterised?

Genotyping

Suggested existing PCR names:

Wheat-F0#12-127kbDel

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation
Cancer

Is the strain available in any form to other researchers

Possibly

APB stock stored as:

Cryopreserved sperm (from 4 mice)

Are live mice available?

Unknown

MTA needs to be signed?

Yes