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Mouse Strain information

APB ID

1228

Added

15/06/2007

Last Edited

10/05/2014

Strain nomenclature:

C57BL/6JAnu-Dsg4tbird/AnuApb

Nickname:

T-Bird

Strain designation name:

C57BL/6JAnu-Dsg4tbird/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: desmoglein 4

Chromosome

Affected Gene Symbol

Dsg4

Protein expression of altered gene:

Unknown

Genetic alteration of gene:

ENU-induced mutation

Location on chromosome (bp):

20594676-20630322 bp, + strand (From VEGA annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:2661061

Synonyms

CDHF13, lah

Allele Name

T-Bird

Allele Symbol

Dsg4tbird

MGI Allele Accession ID

MGI:5007752

Ensembl Gene ID:

ENSMUSG00000001804

Transcript ID:

ENSMUST00000019426

Transcript name:

Dsg4-001

bp change:

A to C at position 777 on cDNA

Exon number:

Exon ID:

ENSMUSE00000445469

cDNA position:

777

Amino acid change:

Threonine to Proline at position 215

Sequence:
747	GGTGCACCCATGTTCATGGTGAACAGGTACACTGGAGAAGTCCGCACGATGTCCAATTTCC	cDNA (forward strand)
205	-G--A--P--M--F--M--V--N--R--Y--T--G--E--V--R--T--M--S--N--F--	protein

Version:

NCBI m37, Ensembl build 62

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Greasy Coat. Affected mice develop a dull, sparse and greasy coat at about ~40 days of age.

Original Genetic Background

C57BL/6

Genetic Background Currently Maintained

C57BL/6 x C57BL10

Coat Colour

Black

Strain Images

Affected mouse

Strain identification

How is this strain characterised?

Phenotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Dermatology

Keywords

Coat
greasy
hair
ENU

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 4 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

MTA needs to be signed?

Yes