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Mouse Strain information

APB ID

221

Added

25/04/2006

Last Edited

11/05/2014

Strain nomenclature:

C57BL/6-Smpxtm1Rph/Apb

Nickname:

Chisel KO

Genetics

Strain Types

Mutant strain

Genetic Details

Targeted knockout

Mode of Inheritance

Recessive

1. Affected Gene Name: small muscle protein, X-linked

Chromosome	X
Affected Gene Symbol	Smpx
Protein expression of altered gene:	Unknown
Genetic alteration of gene:	Flanking loxP site were introducted to exon 2 by insertion of a loxP site into the untranslated region of exon 2 and insertion of a PGK-neo-loxP-ALPP construct into intron 2.
Location on chromosome (bp):	154136842-154190523 bp, + strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:1913356
Synonyms	chisel, Csl
Allele Name	targeted mutation 1, Richard P Harvey
Allele Symbol	Smpxtm1Rph
MGI Allele Accession ID	MGI:2387819

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Mice homozygous for a null mutation do not exhibit defects in heart or skeletal muscle morphology or development

Phenotype Heterozygous State

No reported phenotype

Original Genetic Background

C57BL/6 x 129/Sv

Genetic Background Currently Maintained

C57BL/6

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Developmental biology
Cardiovascular

Keywords

myocyte
insulin
heart

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 5 mice)

Are live mice available?

Unknown

MTA needs to be signed?

Yes