Mouse Strain information
APB ID 2454
Added 14/01/2008
Last Edited 13/12/2022
Strain nomenclature: ENU6PH:043
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: interferon regulatory factor 4  
Chromosome 13
Affected Gene Symbol Irf4
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENu-induced mutation. T434A
Location on chromosome (bp): 30841095-30858796 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1096873
Synonyms IRF-4, Spip
bp change: T to A at position on cDNA
Point mutation sequence:
Insertion/Tagging details:
Guide(s) RNA sequence:
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Hypo IgE response following allergic challenge.
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6 x C57BL/10
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Yes
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • T cell
  • B cell
  • lymphocyte
  • allergy
  • autoimmune
  • immunoglobulin
  • IgE
Is the strain available in any form to other researchers No
APB stock stored as: Cryopreserved sperm (from 4 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


     

 


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