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Mouse Strain information

APB ID

251

Added

28/04/2006

Last Edited

11/05/2014

Strain nomenclature:

129-Ccr1tm1Cge/Apb

Strain designation name:

129-Ccr1tm1Cge/Apb

Genetics

Strain Types

Mutant strain

Genetic Details

Targeted knockout

Mode of Inheritance

Recessive

1. Affected Gene Name: chemokine (C-C motif) receptor 1

Chromosome	9
Affected Gene Symbol	Ccr1
Protein expression of altered gene:	Nil
Genetic alteration of gene:	A PGK-neomycin resistance cassette replaced most of the carboxy terminal coding sequence. Transcript was not detected in bone marrow cells of homozygous mutant animals
Location on chromosome (bp):	123876957-123883399 bp, - strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:104618
Synonyms	Cmkbr1, MIP-1 alphaR, Mip-1a-R
Allele Name	targeted mutation 1, Craig Gerard
Allele Symbol	Ccr1tm1Cge
MGI Allele Accession ID	MGI:1931849

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.

Genetic Background Currently Maintained

129

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation
Haematology

Keywords

chemokine
RANTES
neutrophil
inflammation

Additional Information

Control strain also cryopreserved

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 5 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

Unknown

MTA needs to be signed?

Yes