Home - Australian Phenome Bank

Mouse Strain information

APB ID

282

Added

02/05/2006

Last Edited

11/05/2014

Strain nomenclature:

129/Sv-Ifngrtm1Agt/Apb

Genetics

Strain Types

Mutant strain
Recombinant inbred

Genetic Details

Targeted knockout

Mode of Inheritance

Recessive

1. Affected Gene Name: interferon gamma receptor 1

Chromosome	10
Affected Gene Symbol	Ifngr1
Protein expression of altered gene:	Unknown
Genetic alteration of gene:	Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor.
Location on chromosome (bp):	19518118-19537502 bp, + strand (From NCBI annotation of NCBI Build 34)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:107655
Synonyms	CD119, Ifgr, IFN-gamma R, Ifngr, INF-g receptor, Nktar
Allele Name	targeted mutation 1, Michel Aguet
Allele Symbol	Ifngr1tm1Agt
MGI Allele Accession ID	MGI:1857286
Allele synonyms:	IFn type II receptor, IFN-gamma R-, IFN-gamma R0, IFN-gamma-R KO, IFN-gammaR KO, IFN-gammaR-, IFN-gammaR0, IFN-gammaR1-, IFN-gammaRalpha_, IFNgammaR KO, IFNgR KO, Ifngr-, Ifngr1-

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

abnormal immunoglobulin level: levels of IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus increased susceptibility to viral infection: slightly more susceptible to MCMV viral infection than controls increased susceptibility to Ectromelia virus 100% mortality by day 6-12 after primary infection infection elevated virus titers in all organs tested after primary infection but much improved after secondary infections survive secondary infections

Original Genetic Background

129

Genetic Background Currently Maintained

129

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Cell biology
Haematology
Immunology and inflammation

Keywords

infection
interleukin
splenocyte

Additional Information

Permission for access maybe required from Jax. Control strain also cryopreserved. ASD114, APB ID#4779

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

MTA needs to be signed?

Yes