Mouse Strain information
APB ID 287
Added 03/05/2006
Last Edited 27/09/2016
Strain nomenclature: BALB/c-Il4tm2Nnt/AnuApb
Nickname: Tune
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: interleukin 4  
Chromosome 11
Affected Gene Symbol Il4
Protein expression of altered gene: Unknown
Genetic alteration of gene: A neomycin resistance cassette was inserted into exon 3 of the gene.
Location on chromosome (bp): 53416484-53432171 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:96556
Synonyms IgG1, Il-4
Allele Name targeted mutation 2, Nancy Noben-Trauth
Allele Symbol Il4tm2Nnt
MGI Allele Accession ID MGI:1857195
Allele synonyms: IL-4-
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State abnormal dendritic cell differentiation: numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds decreased IgE level: reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controls decreased IgG1 level: reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controls abnormal dendritic cell antigen presentation: memory CD4 T cells activated by mutant DCs from inflamed lungs secrete low levels of Th2 cytokines increased interferon-gamma secretion: T cells from mice sensitized and challenged with OVA produce more IFN-gamma than controls decreased interleukin-13 secretion: lymphocytes from mice sensitized and challenged with OVA produce less IL-13 than controls decreased interleukin-5 secretion: lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controls decreased susceptibility to autoimmune disorder: mice fail to develop blood eosinophilia after being sensitized and challenged with OVA peptide airway hyperresponsiveness still occurs in these mice though less mucosal cells are found in the inflamed airway hematopoietic system abnormal dendritic cell differentiation: numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds
Original Genetic Background BALB/c
Genetic Background Currently Maintained BALB/c
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Cell biology
Haematology
Immunology and inflammation
Keywords
  • infection
  • inflammation
  • immunoglobulin
  • lymphocyte
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


     

 


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