Mouse Strain information
APB ID 301
Added 03/05/2006
Last Edited 11/08/2020
Strain nomenclature: B6.MRL-Faslpr/AnuApb
Nickname: MRL-Fas
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Spontaneous
Mode of Inheritance Recessive
1.  Affected Gene Name: Fas (TNF receptor superfamily member)  
Chromosome 19
Affected Gene Symbol Fas
Protein expression of altered gene: Unknown
Genetic alteration of gene: Southern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within intron 2.
Location on chromosome (bp): 34365199-34402260 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:95484
Synonyms APO-1, APT1, CD95, Fas, TNFR6, Tnfrsf6
Allele Name lymphoproliferation
Allele Symbol Faslpr
MGI Allele Accession ID MGI:1856334
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Premature death: median survival is 284 days, compared to 795 days for controls. 50% mortality is observed at 13.5 months with 90% mortality at 16 months, significantly reduced from wild-type. 64% survival at 24 weeks. Increased double-negative T cell number. Enlarged spleen. Abnormal lymph node morphology: larger lymph nodes often show extensive hemorrhage and necrosis. Enlarged lymph nodes: by 4 months of age, lymph nodes are increased 10- to 20-fold. nodes are 13 times normal size. generalized lymphadenopathy. Increased immunoglobulin level: IgG and IgM levels are increased in serum at 6 months Decreased interleukin-2 secretion: defect in Il2 activity begins during early life and worsens with age; spleen cells show no stimulated Il2 production upon stimulation with concanavalin A. Increased autoantibody level: increase in thymocytotoxic autoantibodies at 6 months is seen. mice have elevated levels of anti-chromatin antibodies compared to double mutants. Increased anti-nuclear antigen antibody level: anti-nuclear antibodies are present at 6 months of age. mice have significantly increased levels of anti-ssDNA antibodies. mice have elevated levels of anti-chromatin (anti-nucleosome) antibodies compared to double mutants. Increased anti-double stranded DNA antibody level: antibodies are increased relative to controls Increased immature B cell number: plasmablast numbers in spleen are increased relative to wild-type. Increased transitional stage B cell number: higher numbers of T2 B cells in spleen relative to wild-type Increased follicular B cell number: higher in spleen relative to wild-type. Increased marginal zone B cell number: higher in spleen relative to wild-type, Faslpr homozygotes, and Bcl2l11-deficient mice. Abnormal splenic cell ratio: T1:follicular B cell ratio is higher than wild-type or Bcl2l11-deficient mice. Increased splenocyte number: total number of CD19+ splenocytes is higher than wild-type total number of splenocytes is increased relative to wild-type. Glomerulonephritis: Immune complex glomerulonephritis develops by 1 year of age but is much milder than in MRL homozygotes. interstitial lymphoid infiltration is observed at 6 months; glomerular IgG deposits that are exclusively mesangial are observed. Abnormal renal glomerulus morphology: nephritic changes consist of focal increase in mesangial substance and mild mesangial proliferation
Original Genetic Background MRL/Mp
Genetic Background Currently Maintained C57BL/6 x MRL
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Developmental biology
Research tools
Apoptosis
Internal/organ
Metabolism
Cell biology
Keywords
  • B cell
  • Immunoglobulin
  • lymphadenopathy
  • T cell
  • autoimmunity
  • glomerulonephritis
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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