Home - Australian Phenome Bank

Mouse Strain information

APB ID

4799

Added

10/09/2009

Last Edited

10/05/2014

Strain nomenclature:

C57BL/6JAnu-Ighddmit/AnuApb

Nickname:

Dimit; ENU13NIH:039ab

Strain designation name:

C57BL/6JAnu-Ighddmit/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: immunoglobulin heavy constant delta

Chromosome

Affected Gene Symbol

Ighd

Protein expression of altered gene:

Unknown

Genetic alteration of gene:

ENU-induced mutation

Location on chromosome (bp):

114647791-114654535 bp, - strand (From Ensembl annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:96447

Synonyms

IgD

Allele Name

dimit

Allele Symbol

Ighddmit

MGI Allele Accession ID

MGI:4819235

Ensembl Gene ID:

ENSMUSG00000076616

Transcript ID:

ENSMUST00000103424

Transcript name:

Igh-5-201

bp change:

T to A at position 241 on cDNA

Exon number:

Exon ID:

ENSMUSE00000663372

cDNA position:

241

Amino acid change:

Isoleucine to Lysine at position 74

Sequence:
211	CAGAACTGAACCTCAACCACACTTGCACCATAAATAAACCCAAAAGGAAAGAAAAACCTTT	cDNA (reverse strand)
71	-S--E--L--N--L--N--H--T--C--T--I--N--K--P--K--R--K--E--K--P--	protein

Version:

NCBI m37, Ensembl build 55

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Shifted IgD expression measured by flow cytometry

Original Genetic Background

C57BL/6JAnu

Genetic Background Currently Maintained

C57BL/JAnu

Coat Colour

Black

Eye Colour

Black

Strain identification

PCR protocols

ENU13NIH39b (amplifluor)

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation

Keywords

IgD
immunoglobulin
B cell
ENU
NIH

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 4 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

MTA needs to be signed?

Yes