Mouse Strain information
APB ID 4900
Added 09/10/2009
Last Edited 14/05/2014
Strain nomenclature: B6.129-CdKn2atm1Cjs/Apb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: cyclin-dependent kinase inhibitor 2A  
Chromosome 4
Affected Gene Symbol Cdkn2a
Protein expression of altered gene: Nil
Genetic alteration of gene: Replacement of exon 1 beta of the Cdkn2a gene, encoding the translation start site for alternative splice transcript p19ARF, with a neomycin cassette. Note that expression of alternative splice transcript p16Ink4a, transcribed from exon 1 alpha, is not affected by this mutation.
Location on chromosome (bp): 88920377-88940557 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:104738
Synonyms Arf, ARF-INK4a, INK4a-ARF, Ink4a/Arf, MTS1, p16, p16INK4a, p19ARF, p19ARF, Pctr1
Allele Name targeted mutation 1, Charles J Sherr
Allele Symbol Cdkn2atm1Cjs
MGI Allele Accession ID MGI:1926877
Allele synonyms: ARF-, p19ARF-
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State fibrohistocytoma lymphoma carcinoma fibrosarcoma increased incidence of ionizing radiation-induced tumors increased incidence of chemically-induced tumors MEFs (embryonic fibroblasts showed increased proliferative capacity and less responsive to contact inhibition. Abnormal lens morphology: at around P14, the lens undergoes degenerative changes characterized by vacuolization and lens material degradation; an attempt at lens repair beyond P14 is manifested by the accumulation of lens epithelial cells lining a regenerated posterior capsule attachment of the retrolental tissue to the posterior lens and extrusion of lens material into the retrolental tissue. primary vitreous hyperplasia. Microphthalmia Retinal detachment
Original Genetic Background 129X1/SvJ
Genetic Background Currently Maintained C57BL/6 x 129
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Cancer
Keywords
  • tumour
  • lymphoma
  • tumour supressor
  • kinase
  • cyclin
  • oncogene
  • p53
  • Rb
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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