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Mouse Strain information

APB ID

5037

Added

22/02/2010

Last Edited

10/05/2014

Strain nomenclature:

C57BL/6JAnu-Atp11cambr/AnuApb

Nickname:

ENU11B6:221d ; ambrosius

Strain designation name:

C57BL/6JAnu-Atp11cambr/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

X-linked

1. Affected Gene Name: ATPase, class VI, type 11C

Chromosome

Affected Gene Symbol

Atp11c

Genetic alteration of gene:

ENU-induced mutation. Mutation lies in the first base of intron 27 and is a g to a substitution. This results in a STOP being made as part of the last 2 bases of exon 27 (TG (exon) + A (intron)).

Location on chromosome (bp):

57476467-57845873 bp, - strand (From VEGA annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1859661

Synonyms

Allele Name

ambrosius

Allele Symbol

Atp11cambr

MGI Allele Accession ID

MGI:4456247

Allele synonyms:

Atp11cm1Anu

Ensembl Gene ID:

ENSMUSG00000062949

Transcript ID:

ENSMUST00000154051

Transcript name:

Atp11c-001

bp change:

G to A

Intron number:

Genomic position:

57491646

Sequence:
57491676	TTTCTCATTCTTCTGGGGAGGAATTATTTGGtaagcagctgtacctgtgtgagcaatattaa	genomic (reverse strand)
	Exons

Version:

NCBI m37, Ensembl build 57

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

No B cells. Defective ATP11C resulted in a lower rate of phosphatidylserine translocation in pro-B cells and much lower pre-B cell and B cell numbers despite expression of pre-rearranged immunoglobulin transgenes or enforced expression of the prosurvival protein Bcl-2 to prevent apoptosis and abolished pre-B cell population expansion in response to a transgene encoding interleukin 7.

Original Genetic Background

C57BL/6JAnu

Genetic Background Currently Maintained

C57BL/6JAnu

Strain identification

How is this strain characterised?

Phenotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation

Keywords

ENU
B cell
NIH
Wellcome Trust

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

Unknown

MTA needs to be signed?

Yes