Mouse Strain information
APB ID 5345
Added 15/12/2010
Last Edited 06/06/2014
Strain nomenclature: C57BL/6-Figftm1Mach/Apb
Nickname: SS-11 ; Vegfd 2.2.36
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
ES Cell-Line Used W9.5
Mode of Inheritance X-linked
1.  Affected Gene Name: c-fos induced growth factor  
Chromosome X
Affected Gene Symbol Figf
Protein expression of altered gene: Nil
Genetic alteration of gene: A lacZ-pgk-neo cassette was inserted to replace the signal sequence in exon 1 downstream of the translation start site. Northern blot demonstrated lack of expression in mutant E15.5 lungs. Western block confirmed lack of protein in mutants.
Location on chromosome (bp): 160811310-160840582 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:108037
Synonyms VEGF-D, Vegfd
Allele Name c-fos induced growth factor; targeted mutation 1, Marc G Achen
Allele Symbol Figftm1Mach
MGI Allele Accession ID MGI:3576785
Allele synonyms: Vegfdlz
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State No abnormal phenotype detected: homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function. Mice have reduced numbers of lymphatic vessels in lungs.
Phenotype Heterozygous State Normal
Original Genetic Background 129S1/Sv x C57BL/6
Genetic Background Currently Maintained 129S1/Sv x C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Yes
Does it Model a Human Condition? Unknown
Applicable Research Areas Cancer
Cardiovascular
Keywords
  • growth factor
  • Vegf
  • lymphatics
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)
Are live mice available? No
MTA needs to be signed? Yes


     

 


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