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Mouse Strain information
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| APB ID | 5428 | |||
| Added | 10/02/2011 | |||
| Last Edited | 06/06/2014 | |||
| Strain nomenclature: | C57BL/6-Tg(Myh6-TNNI3*wt)1Chs/Apb | |||
| Nickname: | TnI.1; cTnIwt.1 | |||
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Genetics
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| Strain Types |
Mutant strain
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| Genetic Details |
Transgenic
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| Mode of Inheritance | Dominant | |||
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| Mutant Construction Technique | None | |||
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Phenotype
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| Phenotype Homozygous State | Unknown | |||
| Phenotype Heterozygous State | Indistinguishable from non-transgenic wild type C57BL/6 mice | |||
| Original Genetic Background | C57BL/6 | |||
| Genetic Background Currently Maintained | C57BL/6 | |||
| Coat Colour | Black | |||
| Eye Colour | Black | |||
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Strain identification
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| How is this strain characterised? |
Genotyping
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Fertility and Strain maintenance
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Relevant bibliographic / database references
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General information
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| Other Patent Technologies? | No | |||
| Associated IP rights? | Yes | |||
| Does it Model a Human Condition? | Yes | |||
| Description of human condition: | Hypertrophic cardiomyopathy (HCM) is a primary disorder of the myocardium characterized by cardiac hypertrophy. The clinical course of HCM is variable, with inter- and intra-familial variations ranging from benign asymptomatic disease to a malignant phenotype with a high risk of cardiac failure or sudden cardiac death. | |||
| Applicable Research Areas |
Cardiovascular
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| Keywords |
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| Is the strain available in any form to other researchers | Yes | |||
| APB stock stored as: |
Cryopreserved sperm (from 5 mice)
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| Are live mice available? | Unknown | |||
| MTA needs to be signed? | Yes | |||
