Mouse Strain information
APB ID 5445
Added 28/02/2011
Last Edited 10/05/2014
Strain nomenclature: C57BL/6JAnu-Ebf1serv/AnuApb
Nickname: Servalan ; ENU11B6:025b
Strain designation name: C57BL/6JAnu-Ebf1serv/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Spontaneous
Mode of Inheritance Dominant
1.  Affected Gene Name: early B-cell factor 1  
Chromosome 11
Affected Gene Symbol Ebf1
Protein expression of altered gene: Reduced
Genetic alteration of gene: Spontaneous mutation found in facility C57BL/6JAnu strain. Complete duplication of exon 11. Found in 3 pedigrees.
Location on chromosome (bp): 44430819-44821593 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:95275
Synonyms O/E-1, Olf-1, Olf1
Allele Name early B-cell factor 1; Servalan
Allele Symbol Ebf1Serv
MGI Allele Accession ID MGI:5007783
Ensembl Gene ID: ENSMUSG00000057098
Transcript ID: ENSMUST00000081265
Transcript name: Ebf1-001
Version: NCBI m37, Ensembl build 62
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Low B cell numbers in the peripheral blood.
Phenotype Heterozygous State FACs phenotype - Low B cells
Original Genetic Background C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6JAnu
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Haematology
Apoptosis
Keywords
  • B cell
  • NIH
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 3 mice)
Are live mice available? No
MTA needs to be signed? No


     

 


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