Mouse Strain information
APB ID 5475
Added 06/04/2011
Last Edited 15/12/2022
Strain nomenclature: C57BL/6JAnu-Knynknyn/Anu
Nickname: ENU1WT:049
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: Unknown
Chromosome 7
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation. Single nucleotide change A to G
Allele Name kanyon
Allele Symbol knyn
MGI Allele Accession ID MGI:5510719
Allele synonyms: 12WT-49
Version: NCBI m37, Ensembl build 62
Point mutation sequence:
Insertion/Tagging details:
Guide(s) RNA sequence:
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Skeletal defect, exencephaly at embryonic day 13.5. Facial clefts.
Phenotype Heterozygous State Normal
Original Genetic Background C3H/HeH x C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6JAnu
Coat Colour Black
Eye Colour Black
Strain Images
Affected embryo at E13.5. Visual phenotype of exencephaly
Affected embryo at E13.5. Visual phenotype of exencephaly
Strain identification
How is this strain characterised? Genotyping
Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Yes
Description of human condition: frontonasal dysplasias (OMIM 136760)
Applicable Research Areas Developmental biology
Bone
Keywords
  • exencephaly
  • skeletal
  • bone
  • development
  • embryonic
  • ENU
Is the strain available in any form to other researchers Possibly
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? Limited
MTA needs to be signed? Yes


     

 


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