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Mouse Strain information

APB ID

5479

Added

11/04/2011

Last Edited

16/11/2023

Strain nomenclature:

B6.Cg-Stat3tm1Aki Tg(MMTVneu)202Mul/LudApb

Nickname:

Stat 3/MMTV neu

Genetics

Strain Types

Mutant strain

Genetic Details

Transgenic
Targeted knockout

Mode of Inheritance

Recessive

1. Affected Gene Name: Signal transducer and activator of transcription 3

Chromosome	11
Affected Gene Symbol	Stat3
Genetic alteration of gene:	A neomycin resistance cassette replaced 3.0kb of sequence containing exons 20-22.
Location on chromosome (bp):	100746412-100800854 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:103038
Synonyms	Aprf
Allele Name	signal transducer and activator of transcription 3; targeted mutation 1, Shizuo Akira
Allele Symbol	Stat3tm1Aki
MGI Allele Accession ID	MGI:1926814
Allele synonyms:	Stat3-

1. Transgene: transgene insertion 202, William Muller

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Unknown

Phenotype Heterozygous State

Unknown

Original Genetic Background

129; FVB/N

Genetic Background Currently Maintained

C57BL/6

Strain identification

How is this strain characterised?

Genotyping

PCR protocols

Stat3
Gp130dStat
MMTV

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Yes

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation
Cancer
Gastrointestinal
Cell biology

Keywords

signal transduction
kinase

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 10 mice)

Are live mice available?

MTA needs to be signed?

Yes