Mouse Strain information
APB ID 5481
Added 12/04/2011
Last Edited 24/03/2025
Strain nomenclature: C57BL/6-ApcMin/LudApb
Nickname: APC (min) .C57 X C57
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Dominant
1.  Affected Gene Name: adenomatosis polyposis coli  
Chromosome 18
Affected Gene Symbol Apc
Protein expression of altered gene: Unknown
Genetic alteration of gene: A transversion point mutation that alters nucleotide 2549 from a T to an A. This converts codon 850 from one encoding a leucine to a stop codon.
Location on chromosome (bp): 34380578-34478262 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:88039
Synonyms CC1, Min
Allele Name adenomatosis polyposis coli; multiple intestinal neoplasia
Allele Symbol ApcMin
MGI Allele Accession ID MGI:1856318
Allele synonyms: ApcΔ850, Apc-, Apcdelta850, Min, Min-
Point mutation sequence:
Insertion/Tagging details:
Guide(s) RNA sequence:
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Unknown
Phenotype Heterozygous State Increased colonic adenoma incidence: tubular adenomas in the colon. Increased intestinal adenoma incidence: tubular adenomas in the intestine.
Original Genetic Background C57BL/6J
Genetic Background Currently Maintained Unknown
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Yes
Does it Model a Human Condition? Yes
Description of human condition: Adenomatous Polyposis of the Colon; APC; OMIM ID: 175100
Applicable Research Areas Cancer
Internal/organ
Keywords
  • adenoma
  • carcinoma
  • colon
  • mammary gland
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? No
MTA needs to be signed? Yes


     

 


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