Mouse Strain information
APB ID 5506
Added 12/05/2011
Last Edited 06/06/2014
Strain nomenclature: B6.Cg-Brca1tm2Cxd/Apb
Nickname: Brca1 floxed
Genetics
Genetic Details Targeted floxed
Mode of Inheritance Recessive
1.  Affected Gene Name: breast cancer 1  
Chromosome 11
Affected Gene Symbol Brca1
Protein expression of altered gene: Normal
Genetic alteration of gene: Insertion of lox-P sites flanking exon 11. A lox-P flanked neomycin cassette in intron 10 was removed by transient Cre expression in ES cells in this allele. Insertions have no effect on normal gene function.
Location on chromosome (bp): 101350078-101413269 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:104537
Allele Name breast cancer 1; targeted mutation 2, Chu-Xia Deng
Allele Symbol Brca1tm2Cxd
MGI Allele Accession ID MGI:1931238
Allele synonyms: Brca1Co, Brca1flox, Brca1lox
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State Normal
Original Genetic Background 129S6/SvEvTac
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Cancer
Keywords
  • epithelium
  • mammary
  • breast
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? No
MTA needs to be signed? Yes


     

 


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