Mouse Strain information
APB ID 5512
Added 24/05/2011
Last Edited 21/07/2025
Strain nomenclature: B6.129S6-Myctm2Fwa/Apb
Nickname: c-myc fl/fl
Genetics
Strain Types Mutant strain
Genetic Details Targeted floxed
ES Cell-Line Used sv129
Mode of Inheritance Semi-dominant
1.  Affected Gene Name: myelocytomatosis oncogene  
Chromosome 15
Affected Gene Symbol Myc
Protein expression of altered gene: Normal
Genetic alteration of gene: A single loxP site was inserted into intron 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 3. The neomycin cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice.
Location on chromosome (bp): 61816946-61821929 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:97250
Synonyms c-myc, Myc2, Niard, Nird
Allele Name myelocytomatosis oncogene; targeted mutation 2, Frederick W Alt
Allele Symbol Myctm2Fwa
MGI Allele Accession ID MGI:2178233
Allele synonyms: c-mycfl, MYCfl, Mycflox, Myclox
Point mutation sequence:
Insertion/Tagging details:
Guide(s) RNA sequence:
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State Normal
Original Genetic Background 129S6/SvEvTac
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Eye Colour Brown
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Cardiovascular
Developmental biology
Apoptosis
Cell biology
Keywords
  • myc
Is the strain available in any form to other researchers Possibly
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? Limited
MTA needs to be signed? Yes


     

 


Build: 2025.07.17 Non-profit supported by the Australian government  |  © Copyright 2025 Australian Phenomics Facility Last updated: 01/08/2025