Mouse Strain information
APB ID 6808
Added 01/02/2012
Last Edited 09/06/2014
Strain nomenclature: SJL/Mrit-GckMRI32652/MritApb
Nickname: Dudley
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Dominant
1.  Affected Gene Name: Glucokinase  
Chromosome 11
Affected Gene Symbol Gck
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU mutagenesis caused an G to A transition in exon 5 that led to the substitution of methionine for valine at amino-acid residue 182. The mutation increased the level of blood glucose and insulin.
Location on chromosome (bp): 5800823-5850084 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:1270854
Synonyms Gk, hexokinase 4, HK4, MODY2
Allele Name Glucokinase;MRI32562
Allele Symbol GckMRI32562
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Growth retardation Dramatic hyperglycemia
Phenotype Heterozygous State Hyperglycemia Hyperinsulinemia Glucose intolerant
Original Genetic Background SJL
Genetic Background Currently Maintained SJL
Coat Colour White
Strain identification
How is this strain characterised? Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Yes
Description of human condition: Maturity onset diabetes of the young 2
Applicable Research Areas Endocrine deficiency
Diabetes
Metabolism
Keywords
  • Diabetes
  • Glucokinase
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 6 mice)
Are live mice available? No
MTA needs to be signed? Yes


     

 


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