Mouse Strain information
APB ID 6873
Added 17/04/2012
Last Edited 09/06/2014
Strain nomenclature: C57BL/6-Acacatm1Dejs Acacbtm1.1Dejs/AusbApb
Nickname: A1A2f
Strain designation name: C57BL/6-Acacatm1Dejs Acacbtm1Dejs/Ausb
Genetics
Strain Types Mutant strain
Genetic Details Targeted floxed
ES Cell-Line Used Bruce4
Mode of Inheritance Dominant
1.  Affected Gene Name: acetyl-Coenzyme A carboxylase alpha  
Chromosome 11
Affected Gene Symbol Acaca
Protein expression of altered gene: Normal
Genetic alteration of gene: LoxP sites flank exons 42 and 43.
Location on chromosome (bp): 83943174-84215153 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:108451
Synonyms A530025K05Rik, Acac, Acc1, acetyl-CoA carboxylase, LOC327983
Allele Name acetyl-Coenzyme A carboxylase alpha; targeted mutation 1, David E James
Allele Symbol Acacatm1Dejs
MGI Allele Accession ID MGI:5618483
2.  Affected Gene Name: acetyl-Coenzyme A carboxylase beta  
Chromosome 5
Affected Gene Symbol Acacb
Protein expression of altered gene: Normal
Genetic alteration of gene: Exon12 was flanked with loxP sites and a neomycin cassette was added.
Location on chromosome (bp): 114596544-114700770 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:2140940
Synonyms Acc2, Accb
Allele Name acetyl-Coenzyme A carboxylase beta; targeted mutation 1.1, David James
Allele Symbol Acacbtm1.1Dejs
MGI Allele Accession ID MGI:4430244
Allele synonyms: ACC2 KO
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State Normal
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Unknown
Does it Model a Human Condition? No
Applicable Research Areas Metabolism
Keywords
  • ACC1
  • ACC2
  • Flox
  • adipose
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? No
MTA needs to be signed? No


     

 


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