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Mouse Strain information
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| APB ID | 7232 | |||
| Added | 28/11/2012 | |||
| Last Edited | 09/06/2014 | |||
| Strain nomenclature: | C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)9Cbn/Apb | |||
| Nickname: | PbT-I-9 ; C57BL/6-Tg(TCRaB4-46TcrbB4-46)9Cbn | |||
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Genetics
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| Strain Types |
Mutant strain
Recombinant inbred |
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| Genetic Details |
Transgenic
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| Mode of Inheritance | Dominant | |||
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| Mutant Construction Technique | None | |||
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Phenotype
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| Phenotype Homozygous State | Majority of CD8 T cells express the transgenic T cell recepter Va8Vb10 specific for Plasmodium berghei (Pb) parasites. | |||
| Phenotype Heterozygous State | As for homozygous | |||
| Original Genetic Background | C57BL/6 | |||
| Genetic Background Currently Maintained | C57BL/6 | |||
| Coat Colour | Black | |||
| Eye Colour | Black | |||
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Strain identification
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| How is this strain characterised? |
Phenotyping
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| Phenotyping by FACs |
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Fertility and Strain maintenance
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Relevant bibliographic / database references
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General information
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| Associated IP rights? | Unknown | |||
| Does it Model a Human Condition? | Yes | |||
| Description of human condition: | Used to model cerebral/severe malaria | |||
| Research value of this Strain | Understanding the role of CD8 T cells in blood stage malaria infections | |||
| Applicable Research Areas |
Immunology and inflammation
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| Keywords |
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| Additional Information | These mice are unpublished and have not been significantly characterised but would be expected to have a similar phenotype to the related PbT-I-25 strain (ID #5235) | |||
| Is the strain available in any form to other researchers | Yes | |||
| APB stock stored as: |
Cryopreserved sperm (from 5 mice)
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| Are live mice available? | Limited | |||
| MTA needs to be signed? | Yes | |||
