Mouse Strain information
APB ID 7242
Added 06/12/2012
Last Edited 10/09/2014
Strain nomenclature: C57BL/6-Recql4tm2272Arte Gt(ROSA)26Sortm1(EYFP)Cos Tg(Dmp1-Cre)1Jqfe/Apb
Nickname: DMP-1-Cre Recql4
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockin
Targeted reporter
Targeted floxed
ES Cell-Line Used C57BL/6 NTac ES cells
Mode of Inheritance Dominant
1.  Affected Gene Name: gene trap ROSA 26, Philippe Soriano  
Chromosome 6
Affected Gene Symbol Gt(ROSA)26Sor
Genetic alteration of gene: A construct containing a floxed PGK-neo cassette and an enhanced yellow fluorescent protein (EYFP) gene was inserted into the Gt(ROSA)26Sor locus via homologous recombination. The floxed neo cassette contains a strong tpA stop sequence which prevents the transcription of EYFP.
Location on chromosome (bp): 113017422-113027327 bp, - strand Genetic Position: Chr6, 52.73 cM
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:104735
Synonyms beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1
Allele Name gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini
Allele Symbol Gt(ROSA)26Sortm1(EYFP)Cos
MGI Allele Accession ID MGI:2449038
Allele synonyms: R-EYFP, R26-stop-EYFP, R26R EYFP, R26R-EYFP, R26RYFP, R26RYFP, Rosa26-EGFPloxP, ROSA26-LoxP-STOP-LoxP-EYFP, ROSA26-loxP-Stop-loxP-YF, ROSA26-stop-YFP reporter, ROSA26-YFP, Rosa26-YFPfl, ROSA26floxSTOP-YFP, Rosa26YFPStop, ROSA26R-YFP, Rosa26YFP
2.  Affected Gene Name: RecQ protein-like 4  
Chromosome 15
Affected Gene Symbol Recql4
Protein expression of altered gene: Unknown
Genetic alteration of gene: Exon 9-10 of Recql4 flanked by LoxP elements
Location on chromosome (bp): 76534171-76540906 bp, - strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:1931028
Allele Name RecQ protein-like 4; targeted mutation 1.1, TaconicArtemis
Allele Symbol Recql4tm1.1Arte
MGI Allele Accession ID MGI:5645319
Allele synonyms: Recql4fl/fl
1.   Transgene: transgene insertion 1, Jian Q Feng  
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Homozygous animals are normal, fertile and viable (floxed line with eYFP reporter of cre activity)
Phenotype Heterozygous State Normal, fertile and viable (floxed line with eYFP reporter of cre activity)
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
Suggested existing PCR names: R26eYFP, Recql4fl/fl
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Other Patent Technologies? yes - Cre:lox
Associated IP rights? Unknown
Does it Model a Human Condition? Yes
Description of human condition: Rothmund-Thomson Syndrome
Research value of this Strain Cancer, familail genetics
Applicable Research Areas Haematology
Cancer
Developmental biology
Bone
Keywords
  • Recql4
  • R26eYFP
  • Rothmund-Thomson Syndrome
Is the strain available in any form to other researchers Possibly
APB stock stored as: Cryopreserved sperm (from 3 mice)
Are live mice available? Limited
MTA needs to be signed? Yes


     

 


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