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Mouse Strain information

APB ID

7345

Added

28/05/2013

Last Edited

09/06/2014

Strain nomenclature:

B6.129P2-Ptentm2Mak Tg(MMTV-Cre)4Mam/Apb

Nickname:

PTEN lox P locus/MMTV CRE

Genetics

Strain Types

Mutant strain

Genetic Details

Transgenic: CRE
Targeted floxed

Mode of Inheritance

Dominant

1. Affected Gene Name: phosphatase and tensin homolog

Chromosome	19
Affected Gene Symbol	Pten
Genetic alteration of gene:	One loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele.
Location on chromosome (bp):	32757497-32826160 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:109583
Allele Name	phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
Allele Symbol	Ptentm2Mak
MGI Allele Accession ID	MGI:2182005
Allele synonyms:	PTENCo, Ptenf, Ptenfl, Ptenflox, PtenL, PtenloxP

1. Transgene: transgene insertion 4, Lothar Hennighausen

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Neoplastic proliferation of prostate and skin tissues

Phenotype Heterozygous State

Susceptible to tumour development

Original Genetic Background

129P2/OlaHsd ; FVB

Genetic Background Currently Maintained

C57BL/6

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Research value of this Strain

Prostate cancer

Applicable Research Areas

Cancer
Reproduction

Keywords

Cre recombinase
pten
prostate
hyperplasia

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 5 mice)

Are live mice available?

MTA needs to be signed?

Yes