Mouse Strain information
APB ID 7345
Added 28/05/2013
Last Edited 09/06/2014
Strain nomenclature: B6.129P2-Ptentm2Mak Tg(MMTV-Cre)4Mam/Apb
Nickname: PTEN lox P locus/MMTV CRE
Genetics
Strain Types Mutant strain
Genetic Details Transgenic: CRE
Targeted floxed
Mode of Inheritance Dominant
1.  Affected Gene Name: phosphatase and tensin homolog  
Chromosome 19
Affected Gene Symbol Pten
Genetic alteration of gene: One loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele.
Location on chromosome (bp): 32757497-32826160 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:109583
Allele Name phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
Allele Symbol Ptentm2Mak
MGI Allele Accession ID MGI:2182005
Allele synonyms: PTENCo, Ptenf, Ptenfl, Ptenflox, PtenL, PtenloxP
1.   Transgene: transgene insertion 4, Lothar Hennighausen  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Neoplastic proliferation of prostate and skin tissues
Phenotype Heterozygous State Susceptible to tumour development
Original Genetic Background 129P2/OlaHsd ; FVB
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Research value of this Strain Prostate cancer
Applicable Research Areas Cancer
Reproduction
Keywords
  • Cre recombinase
  • pten
  • prostate
  • hyperplasia
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? No
MTA needs to be signed? Yes


     

 


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