Mouse Strain information
APB ID 7384
Added 28/07/2013
Last Edited 09/06/2014
Strain nomenclature: B6.129S4-H2-Ab1tm1Hpl/Apb
Nickname: B6.MHCII-GFP
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockin
Mode of Inheritance Dominant
1.  Affected Gene Name: histocompatibility 2, class II antigen A, beta 1  
Chromosome 17
Affected Gene Symbol H2-Ab1
Genetic alteration of gene: This allele encodes an intact class II beta chain with an EGFP moiety fused to the carboxy terminal. The fusion protein was detected in whole spleen lysates, whereas free EGFP was not. An intronic floxed neo cassette upstream of the 3' untranslated region was included for selection.
Location on chromosome (bp): 34263209-34269418 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:103070
Synonyms Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-A, I-Abeta, Rmcs1
Allele Name histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Hidde Ploegh
Allele Symbol H2-Ab1tm1Hpl
MGI Allele Accession ID MGI:2387946
Allele synonyms: I-Ab-GFP, MHC II-EGFP, MHCII-EGFP
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Express MHCII GFP fusion protein.
Phenotype Heterozygous State Express MHCII GFP fusion protein. Mice are immunologically indistinguishable from wild-type controls
Original Genetic Background 129/S4
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • major histocompatibility complex
  • MHCII
  • antigen presentation
  • GFP
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? Limited
MTA needs to be signed? Yes


     

 


Our other websites Australian Phenomics Facility Phenomics Australia Missense Mutation Library
Build: 2025.06.05 Non-profit supported by the Australian government  |  © Copyright 2025 Australian Phenomics Facility Last updated: 17/07/2025