Home - Australian Phenome Bank

Mouse Strain information

APB ID

7856

Added

05/03/2015

Last Edited

03/01/2023

Strain nomenclature:

C57BL/6NCrlANu-Pik3ap1m1Anu/AnuApb

Nickname:

ENU30:057

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: phosphoinositide-3-kinase adaptor protein 1

Chromosome

Affected Gene Symbol

Pik3ap1

Protein expression of altered gene:

Unknown

Genetic alteration of gene:

ENU-induced mutation

Location on chromosome (bp):

41274218-41385070 bp, - strand From Ensembl annotation of GRCm38

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1933177

Synonyms

1810044J04Rik, BCAP

Allele Name

mutation 1, Australian National University

Allele Symbol

Pik3ap1m1Anu

Ensembl Gene ID:

ENSMUSG00000025017

Transcript ID:

ENSMUST00000059672

Transcript name:

Pik3ap1-201

bp change:

G to A at position 1195 on cDNA

Exon number:

Exon ID:

ENSMUSE00000147300

cDNA position:

1195

Amino acid change:

Alanine to Valine at position 365

Sequence:
1165	TGCTGCTCACCTGTCCAGGGGCTCTCCAGGCCTACAGTGTAGCCAACAAGCACGGCCACTA	cDNA (reverse strand)
355	L--L--L--T--C--P--G--A--L--Q--A--Y--S--V--A--N--K--H--G--H--Y	protein

Version:

NCBI m38, Ensembl build 78

Point mutation sequence:

Insertion/Tagging details:

Guide(s) RNA sequence:

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

High IgM expression on mature B cells

Original Genetic Background

C57BL/6NCrlAnu

Genetic Background Currently Maintained

C57BL/6NCrlAnu

Coat Colour

Black

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation

Keywords

B cell
IgM

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 5 mice)

Are live mice available?

Unknown

MTA needs to be signed?

Yes