Mouse Strain information
APB ID 8289
Added 22/08/2017
Last Edited 09/10/2024
Strain nomenclature: C57BL/6-Prkaa1em2(T481/S487A)/Ausb
Nickname: AMPK a1(T481/S487A) KI
Genetics
Strain Types Mutant strain
Genetic Details CRISPR targeted
Mode of Inheritance Recessive
1.  Affected Gene Name: protein kinase, AMP-activated, alpha 1 catalytic subunit  
Chromosome 15
Affected Gene Symbol Prkaa1
Protein expression of altered gene: Unknown
Genetic alteration of gene: AMPK alpha 1, Chromosome 15, T481A and S487A both with knock in mutation constitutive
Location on chromosome (bp): 5143861-5181899 bp, + strand (From NCBI annotation of GRCm3)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:2145955
Synonyms AMPKalpha1, C130083N04Rik
Point mutation sequence:
Insertion/Tagging details:
Guide(s) RNA sequence:
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State Normal
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 7 mice)
Are live mice available? Limited
MTA needs to be signed? Yes


     

 


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