Home - Australian Phenome Bank

Mouse Strain information

APB ID

8390

Added

18/12/2017

Last Edited

11/12/2019

Strain nomenclature:

B6.129-Fat4tm1.1Hmc/HmcApb

Nickname:

Fat4 flox

Genetics

Strain Types

Mutant strain

Genetic Details

Targeted floxed

Mode of Inheritance

Recessive

1. Affected Gene Name: FAT atypical cadherin 4

Chromosome	3
Affected Gene Symbol	Fat4
Genetic alteration of gene:	A loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. This allele is derived from line 2E11 in which targeting occured as expected. Subsequent Cre mediated recombination removed exon 3.
Location on chromosome (bp):	38886940-39011985 bp, + strand (From VEGA annotation of GRCm38)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:3045256
Synonyms	6030410K14Rik
Allele Name	FAT atypical cadherin 4; targeted mutation 1.1, Helen McNeill
Allele Symbol	Fat4tm1.1Hmc
MGI Allele Accession ID	MGI:3846573
Allele synonyms:	Fat4-, Fat42E11 deltaflox

Mutant Construction Technique

CRE recombinase-loxP technology

Phenotype

Phenotype Homozygous State

Normal

Phenotype Heterozygous State

Normal

Original Genetic Background

129P2

Genetic Background Currently Maintained

C57BL/6

Coat Colour

Black

Strain identification

How is this strain characterised?

Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Developmental biology

Keywords

cystic kidney disease

Additional Information

Genotype of mice submitted for sperm cryopreservation has been verified by the researcher using tissue samples collected at the time of sperm cryopreservation - all fl/fl

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 5 mice)

Are live mice available?

Unknown

MTA needs to be signed?

Yes