Mouse Strain information
APB ID 8632
Added 20/12/2018
Last Edited 21/12/2018
Strain nomenclature: B6.Cg-Efnb2tm2And Tg(Dmp1-cre)1Jqfe
Nickname: Dmp1Cre.Efnb2
Genetics
Strain Types Mutant strain
Genetic Details Transgenic: CRE
Targeted floxed
Mode of Inheritance Recessive
1.  Affected Gene Name: ephrin B2  
Chromosome 8
Affected Gene Symbol Efnb2
Genetic alteration of gene: A loxP site was inserted 45 bp upstream in the 5' UTR and a floxed PGKneo cassette was inserted downstream of the first exon. The floxed PGKneo cassette was removed by transient Cre expression in the ES cells which resulted in a floxed intact exon I.
Location on chromosome (bp): 8617434-8661242 bp, - strand (From Ensembl annotation of GRCm38)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:105097
Synonyms ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1
Allele Name ephrin B2; targeted mutation 2, David J Anderson
Allele Symbol Efnb2tm2And
MGI Allele Accession ID MGI:2176538
Allele synonyms: Efnb2flox, EphrinB2LoxP
1.   Transgene: transgene insertion 1, Jian Q Feng  
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Normal bone shape and cortical width with a low bone material strength due to hypermineralization
Phenotype Heterozygous State Unknown
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Bone
Keywords
  • homeostasis
  • osteoblasts
  • EphB4
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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