Mouse Strain information
APB ID 8832
Added 04/12/2019
Last Edited 05/12/2019
Strain nomenclature: C57BL/6N-Csf2rbtm1c(EUCOMM)Hmgc
Nickname: Csf2rb fl/fl
Genetics
Strain Types Mutant strain
Genetic Details Targeted floxed
Mode of Inheritance Recessive
1.  Affected Gene Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)  
Chromosome 15
Affected Gene Symbol Csf2rb
Genetic alteration of gene: The L1L2_Bact_P cassette was inserted at position 78337719 of Chromosome 15 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 78339575. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, deleting the lacZ and neomycin expression cassettes.
Location on chromosome (bp): 78325800-78351001 bp, + strand (From NCBI annotation of GRCm38)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:1339759
Synonyms AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb
Allele Name colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Symbol Csf2rbtm1c(EUCOMM)Hmgu
MGI Allele Accession ID MGI:5792881
Allele synonyms: Csf2rbfl
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State Normal
Original Genetic Background C57BL/6N-Atm1Brd
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Haematology
Keywords
  • GM-CSF
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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