Mutation details: A loxP site was inserted upstream of exon 6 with an additional loxP site and a frt-flanked neomycin/EGFP cassette inserted downstream of exon 6. The neomycin/EGFP cassette was subsequently removed by crossing founder mice with a flpe transgenic mice, leaving exon 6 floxed. Removal of exon 6 by cre-mediated recombination will leave exon 7 out-of-frame and create a null allele.
Location on chromosome (bp):
44437177-44528501 bp, - strand (From Ensembl annotation of GRCm38)
MGI Gene Accession ID
Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)
Mice have defects in tissue resident memory T cells, but are otherwise relatively normal
Phenotype Heterozygous State
Normal
Genetic Background Currently Maintained
C57BL/6
Strain identification
How is this strain characterised?
Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Female
Male
Are homozygous mice viable?
Yes
Yes
Are homozygous mice fertile?
Yes
Yes
Are heterozygotes / hemizygotes* fertile?
Yes
Yes
* Hemizygote as used here refers to males carring a mutation on the X chromosome or mice of either sex
carrying an inserted transgene with no homologous allele on the other chromosome.
